Journal of Veterinary Cardiology最新文献

{"title":"Echocardiographic estimates of stroke volume in healthy dogs: comparability, reference intervals, and reproducibility","authors":"K.E. Davis ,&nbsp;L.C. Visser ,&nbsp;J.A. Boon ,&nbsp;E.S. Ross ,&nbsp;J.N. Sankisov ,&nbsp;A.C. Laws","doi":"10.1016/j.jvc.2024.10.008","DOIUrl":"10.1016/j.jvc.2024.10.008","url":null,"abstract":"<div><h3>Introduction</h3><div>: This study aimed to compare estimates of stroke volume (SV) from different anatomic sites and to generate reference intervals for indices such as shunt volume (ShuntVol) or regurgitant volume (RegVol) in a large sample of healthy dogs.</div></div><div><h3>Animals, Materials and Methods</h3><div>Ninety healthy dogs underwent an echocardiogram, where SV was assessed at the level of the pulmonary valve (SV_PV), aortic valve (SV_AV), mitral valve (SV_MV), and left ventricle using the difference in end-diastolic volume and end-systolic volume from a right parasternal long-axis four-chamber view (SV_{LV_RPLx}) and left apical four-chamber view (SV_{LV_Ap4Ch}). Eight dogs underwent repeated echocardiograms by the same operator on three different days and by three different operators on the same day. Bland–Altman plots and 95% reference intervals were generated. Reproducibility was described using coefficients of variation and reproducibility coefficients.</div></div><div><h3>Results</h3><div>Mean differences (95% limits of agreement) for ShuntVol (SV_PV-SV_AV), RegVol_{LV_RPLx} (SV_{LV_RPLx}-SV_AV), RegVol_{LV_Ap4Ch} (SV_{LV_Ap4Ch}-SV_AV), and RegVol_MV (SV_MV-SV_AV) were as follows: −0.14 (−0.72, 0.44), −0.05 (−0.59, 0.48), −0.16 (−0.71, 0.39), and 0.12 (−0.76, 1.00) mL/kg, respectively. All but RegVol_{LV_RPLx} showed significant (P&lt;0.01) fixed bias. Reference intervals for ShuntVol, RegVol_{LV_RPLx}, RegVol_{LV_Ap4Ch}, and RegVol_MV were as follows: −0.85-0.64, −0.65-0.58, −0.77-0.52, and −0.91-1.06 mL/kg, respectively. Intra-operator and interoperator coefficients of variation were lowest for SV_AV and highest for SV_MV and SV_{LV_AP4Ch}.</div></div><div><h3>Conclusions</h3><div>Echocardiographic estimates of SV are not interchangeable and can exhibit wide limits of agreement. Reference intervals help provide a frame of reference to assess disease severity in dogs with a shunting lesion (ShuntVol) and mitral regurgitation (RegVol).</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"57 ","pages":"Pages 27-38"},"PeriodicalIF":1.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of different antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation","authors":"G. Romito ,&nbsp;M. Bertarello ,&nbsp;C. Mazzoldi ,&nbsp;S. Fasoli ,&nbsp;F. Dondi ,&nbsp;P. Castagna ,&nbsp;N.G. Pelle ,&nbsp;P. Paradies ,&nbsp;C. Valente ,&nbsp;H. Poser ,&nbsp;C. Guglielmini","doi":"10.1016/j.jvc.2024.10.006","DOIUrl":"10.1016/j.jvc.2024.10.006","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>Studies comparing the effects of antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation (AF) are currently limited; therefore, this study aimed to report detailed data on the efficacy and therapy-related side-effects (TRSEs) of different antiarrhythmic protocols in dogs with secondary AF.</div></div><div><h3>Animals, Materials, and Methods</h3><div>Dogs with secondary AF treated with combination therapy with diltiazem and digoxin (CT_Dilt+Digox), diltiazem monotherapy (MT_Dilt), digoxin monotherapy (MT_Digox), or amiodarone monotherapy (MT_Amiod) were retrospectively evaluated. Signalment, clinical, diagnostic, therapeutic, and outcome data were retrieved. Electrocardiographically, antiarrhythmic efficacy was defined by a reduction in the mean heart rate on Holter monitoring ≤125 beats/minutes. Statistical analysis was performed to compare selected data, including the rate of efficacy and TRSEs as well as the median survival time, between dogs treated with different antiarrhythmic protocols.</div></div><div><h3>Results</h3><div>Fifty-four dogs were included, with 28 receiving the CT_Dilt+Digox and 26 receiving monotherapies (MT_Digox = 16; MT_Dilt = 5; MT_Amiod = 5). The efficacy rate documented in dogs treated with CT_Dilt+Digox was significantly higher than that observed in dogs from the composite monotherapy group (i.e., MT_Dilt+MT_Digox+MT_Amiod) (P=0.048). The rate of TRSEs documented in dogs treated with CT_Dilt+Digox was similar to that observed in dogs from the composed monotherapy group (P=0.129). The median survival time documented in dogs treated with CT_Dilt+Digox was significantly longer than that observed in dogs of the MT_Digox group (P=0.01).</div></div><div><h3>Discussion</h3><div>In dogs with secondary AF we included, CT_Dilt+Digox was well tolerated and provided clinically relevant benefits compared to the use of a single antiarrhythmic drug.</div></div><div><h3>Limitations</h3><div>Retrospective design; heterogeneous sample size of categories analyzed; clinicopathological data available for many, but not all, dogs.</div></div><div><h3>Conclusions</h3><div>Our findings support the indication to generally consider CT_Dilt+Digox as a first-line antiarrhythmic treatment in dogs with secondary AF.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"57 ","pages":"Pages 8-19"},"PeriodicalIF":1.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and hybrid interventional and surgical removal of ectopic heartworms (Dirofilaria immitis) in a dog","authors":"B.G. Barnett,&nbsp;H.K. Hammond,&nbsp;C.L. Chen,&nbsp;J.A. Grimes,&nbsp;L.E. Markovic","doi":"10.1016/j.jvc.2024.10.005","DOIUrl":"10.1016/j.jvc.2024.10.005","url":null,"abstract":"<div><div>An adult male castrated French bulldog mix was presented for suspected caval syndrome and bilateral pelvic limb paresis. After emergency transjugular heartworm extraction, abdominal ultrasound revealed occlusive adult heartworms in the abdominal aorta extending into the pelvic limb arteries. Hybrid interventional and surgical extraction was pursued, and heartworms were removed via bilateral femoral arteriotomy and caudal abdominal aortotomy. Ectopic dirofilariasis involving the aorta and pelvic limb arteries is rarely reported; therefore, the underlying mechanism, incidence, and treatment of aberrant heartworms are poorly understood. This case report describes a unique hybrid approach involving heartworm extraction via femoral arteriotomy interventionally and aortotomy surgically.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"57 ","pages":"Pages 20-26"},"PeriodicalIF":1.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transjugular patent ductus arteriosus occlusion in a cat using the Vet-PDA Occluder™ device","authors":"L. García-Guasch ,&nbsp;A.M. Bello ,&nbsp;A. García-Urdiales ,&nbsp;D. Massegur-Yeste ,&nbsp;C. Olmedo-Bosch","doi":"10.1016/j.jvc.2024.10.004","DOIUrl":"10.1016/j.jvc.2024.10.004","url":null,"abstract":"<div><div>A 5-month-old, female, entirely domestic short-haired cat was referred for evaluation of a continuous heart murmur. No associated clinical signs were reported. Transthoracic echocardiography revealed a large, left-to-right shunting patent ductus arteriosus (PDA). Transjugular occlusion of the defect was achieved using a Vet-PDA Occluder™ device, a new conic-shaped nitinol spiral device designed for PDA closure in small-sized dogs weighing less than 3 kg. Resolution of the continuous heart murmur was identified after device deployment. This case report demonstrates that the Vet-PDA Occluder™ can be a feasible option in feline patients for the occlusion of PDA and describes the technique step by step.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"57 ","pages":"Pages 1-7"},"PeriodicalIF":1.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement of echocardiographic and catheterization-based methods of transpulmonary pressure gradient measurement in dogs","authors":"K.E. Murphy ,&nbsp;L.E. Markovic ,&nbsp;D.B. Adin ,&nbsp;K.E. Moy-Trigilio ,&nbsp;A.E. Coleman","doi":"10.1016/j.jvc.2024.10.001","DOIUrl":"10.1016/j.jvc.2024.10.001","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>Doppler echocardiographic estimation of transpulmonary pressure gradient (PG) is widely used to determine severity of pulmonary valve stenosis and indication for transcatheter intervention. The objective of this study was to describe agreement between Doppler echocardiographic methods of transpulmonary PG estimation and direct peak-to-peak pressure gradient at catheterization (PG_cath) in dogs. We hypothesized that with reference to PG_cath, mean echocardiographic PG (PG_echo-mean) would have less bias than peak modal instantaneous echocardiographic PG (PG_echo-peak).</div></div><div><h3>Animals</h3><div>Client-owned dogs with congenital pulmonary valve stenosis that underwent balloon pulmonary valvuloplasty at one of two veterinary teaching hospitals between June 2012 and May 2022 were included in this study.</div></div><div><h3>Materials and Methods</h3><div>Cases that underwent transthoracic echocardiography and subsequent balloon pulmonary valvuloplasty separated by 30 or fewer days were retrospectively identified. For each echocardiogram, average PG_echo-mean (mmHg) and average PG_echo-peak (mmHg) were calculated from stored spectral Doppler recordings. Peak right ventricular-to-peak pulmonary artery PG data (mmHg) were obtained from catheterization reports. Bland–Altman analysis was used to assess agreement between echocardiographic and catheterization data.</div></div><div><h3>Results</h3><div>Data from 209 dogs (n = 215 instances) were evaluated. Proportional bias, greater at higher gradients, was observed for PG_echo-mean versus PG_cath (P&lt;0.001). A constant bias of −38.12 mmHg was observed for PG_echo-peak versus PG_cath (P=0.62). Bias for both echocardiographic variables had wide limits of agreement that increased with PG.</div></div><div><h3>Conclusions</h3><div>PG_echo-mean and PG_echo-peak underestimated and overestimated PG_cath, respectively, preventing their interchangeability with PG_cath.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"56 ","pages":"Pages 116-125"},"PeriodicalIF":1.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced cardiac imaging","authors":"B.A. Scansen","doi":"10.1016/j.jvc.2024.10.003","DOIUrl":"10.1016/j.jvc.2024.10.003","url":null,"abstract":"","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"56 ","pages":"Page 110"},"PeriodicalIF":1.5,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142537871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral pulmonary edema in a dog with a large, left-to-right shunting patent ductus arteriosus","authors":"M. McMullen,&nbsp;K.L. Maneval,&nbsp;C.S. Ferrel,&nbsp;M. Holland,&nbsp;R.L. Winter","doi":"10.1016/j.jvc.2024.10.002","DOIUrl":"10.1016/j.jvc.2024.10.002","url":null,"abstract":"<div><div>A 4-month-old, 5.0-kg male castrated mixed-breed dog was presented for further evaluation of a heart murmur. A grade 6/6 left basilar, continuous heart murmur, and bounding femoral arterial pulses were observed, consistent with a patent ductus arteriosus (PDA). Transthoracic echocardiography confirmed the diagnosis of a large, left-to-right shunting PDA with severe left heart volume overload. Thoracic radiography revealed severe, alveolar lung disease in the right cranial, right middle, and right caudal lung lobes; no pulmonary infiltrate was observed in the left lung lobes. Unilateral pulmonary edema secondary to the PDA was diagnosed, which later resolved with medical management and transcatheter occlusion of the PDA with an Amplatz Canine Ductal Occluder. Unilateral pulmonary edema secondary to a PDA has not been previously reported in the dog.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"56 ","pages":"Pages 111-115"},"PeriodicalIF":1.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal title page and editorial board","authors":"","doi":"10.1016/S1760-2734(24)00087-0","DOIUrl":"10.1016/S1760-2734(24)00087-0","url":null,"abstract":"","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"55 ","pages":"Page i"},"PeriodicalIF":1.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142359008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, electrocardiographic, and diagnostic imaging features and outcomes in cats with electrocardiographic diagnosis of ventricular pre-excitation: a retrospective study of 23 cases (2010–2022)","authors":"E.A. Gavic ,&nbsp;C.D. Stauthammer ,&nbsp;A.K. Masters ,&nbsp;K.R.S. Morgan ,&nbsp;A. Rendahl ,&nbsp;M. Ciccozzi ,&nbsp;K. Beekmann ,&nbsp;R. George ,&nbsp;E. Herrold ,&nbsp;L.E. Markovic ,&nbsp;K. Schober ,&nbsp;S.S. Tjostheim ,&nbsp;K. Wright","doi":"10.1016/j.jvc.2024.09.003","DOIUrl":"10.1016/j.jvc.2024.09.003","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>Ventricular pre-excitation (VPE) occurs when atrial electrical impulses prematurely excite the ventricles through an aberrant muscle bundle known as an accessory pathway (AP). Orthodromic atrioventricular reciprocating tachycardia is a re-entrant, narrow complex supraventricular tachycardia (SVT), maintained through retrograde conduction over an AP. The study aimed to describe patient signalments, clinical signs, electrocardiographic (ECG) and diagnostic imaging features, treatments, prognostic variables, and outcomes in cats with ECG diagnosis of VPE.</div></div><div><h3>Animals</h3><div>Twenty-three cats diagnosed with VPE between January 2010 and August 2022 were included in this study.</div></div><div><h3>Materials and Methods</h3><div>This was a multicenter, retrospective study with twenty-three cats diagnosed with VPE between January 2010 and August 2022. Ventricular pre-excitation diagnosis was based on ECG evidence of shortened PR interval, delta wave, and prolonged QRS duration. The median survival time (MST) was estimated by the Kaplan-Meier curve. Log-rank tests were performed to assess for an association between clinical signs or presence of structural heart disease on the MST.</div></div><div><h3>Results</h3><div>Fourteen (60.8%) cats with VPE also had SVT documented on ECG, with 7 of 14 with ECG confirmation of orthodromic atrioventricular reciprocating tachycardia. Four (17.4%) cats had suspected AP-mediated tachyarrhythmia based on associated clinical signs. Common presenting signs included collapse (15/23; 65.2%) and respiratory distress (14/23; 60.8%). Five (21.7%) cats were asymptomatic. Heart rate during SVT ranged from 310 to 420 bpm (median: 375 bpm). Initial treatment included atenolol (10/18), sotalol (5/18), diltiazem (2/18), and amiodarone (1/18). From the date of diagnosis, MST was 1872 days (5.1 years).</div></div><div><h3>Conclusions</h3><div>The majority of cats with VPE also had symptomatic SVT. The prognosis for cats with VPE is considered good with an MST of greater than five years.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"56 ","pages":"Pages 97-109"},"PeriodicalIF":1.5,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of vector-borne pathogens and cardiac Striatin genotype on survival in boxer dogs with arrhythmogenic right ventricular cardiomyopathy","authors":"B. Ditzler ,&nbsp;E. Lashnits ,&nbsp;K.M. Meurs ,&nbsp;R.G. Maggi ,&nbsp;M. Yata ,&nbsp;P. Neupane ,&nbsp;E.B. Breitschwerdt","doi":"10.1016/j.jvc.2024.09.002","DOIUrl":"10.1016/j.jvc.2024.09.002","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>Risk factors for severe disease in boxer dogs with arrhythmogenic right ventricular cardiomyopathy (ARVC) are not well understood. This study's objective was to determine whether Striatin genotype or canine vector-borne pathogen (CVBP) exposure/infection in boxer dogs with ARVC was associated with disease severity or survival.</div></div><div><h3>Animals</h3><div>Sixty-four client-owned, adult boxer dogs with ARVC were included in the study.</div></div><div><h3>Materials and Methods</h3><div>This was a prospective descriptive study. Disease severity was determined by echocardiography and Holter monitoring. Potential risk factors included CVBP exposure/infection (<em>Anaplasma</em> spp.<em>, Babesia</em> spp., <em>Bartonella</em> spp., <em>Borrelia burgdorferi</em>, <em>Dirofilaria immitis, Ehrlichia</em> spp., and <em>Rickettsia</em> spp.) and Striatin genotype.</div></div><div><h3>Results</h3><div>The median survival time after enrollment was 270 days (95% confidence interval [CI]: 226–798 days), and the median age at the time of death or censoring was 11 years (95% CI: 10.3–11.7 years). Striatin mutation genotype results included 31 homozygous-negative, 26 heterozygous-positive, and seven homozygous-positive boxer dogs. Ten boxer dogs had exposure to <em>Bartonella</em> spp., four to <em>Rickettsia,</em> two to <em>Ehrlichia</em> spp., and one to <em>Anaplasma</em> spp. Striatin homozygous–positive boxer dogs had a shorter median survival time (93 days vs. 373 days for heterozygous [P=0.010] and 214 days for homozygous negative [P=0.036]). Exposure/infection to CVBP was not associated with median survival time or age at the time of death.</div></div><div><h3>Discussion</h3><div>Striatin homozygous positive boxer dogs with ARVC had shorter survival times and were younger at the time of death. Exposure or infection with CVBP did not appear to influence survival time.</div></div><div><h3>Study Limitations</h3><div>Selection bias for more severe disease limited the ability to assess the relationship between CVBP infection/exposure and disease severity, and overall small sample size limited statistical power. Extracardiac disease and treatment protocols were not controlled.</div></div><div><h3>Conclusions</h3><div>Striatin genotype screening can be considered for prognostic information. Exposure/infection to CVBP appears unlikely to influence survival time for boxer dogs with ARVC.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"56 ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}