Journal of Veterinary Cardiology最新文献

Journal title page and editorial board

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-03-21 DOI: 10.1016/S1760-2734(25)00019-0

引用次数: 0

Clinical and imaging characteristics of patent ductus arteriosus in Standard poodles and their crossbreeds

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-03-12 DOI: 10.1016/j.jvc.2025.03.005

S. Lim , S. Wesselowski , S. Kadotani , R.L. Winter , A.B. Saunders

Introduction/Objectives

Standard poodle (SP)/Standard poodle crossbred (SP-C) dogs have gained popularity with limited literature representation. The study objective was to report clinical, imaging, and procedural data in SP/SP-C dogs with patent ductus arteriosus (PDA).

Animals

Breeds included SP (12/30), Goldendoodle (9/30), Labradoodle (7/30), and Bernedoodle (2/30). At presentation, dogs were 0.6 years old (0.2–6.0) and weighed 14.8 kg (3.1–25.6). Nine had concurrent congenital heart disease. Thirteen required diuretic therapy.

Materials and Methods

A multi-institutional retrospective study including 30 client-owned SP/SP-C dogs was conducted. Data are reported as median and range.

Results

Intra-operative imaging was performed with angiography (n = 28) and transesophageal echocardiography (TEE) (n = 20), with discrepancies in morphology classification identified in six dogs in which both modalities were performed. Pulmonary ostium diameter measured by TEE, ampulla diameter 4 mm above the ostium measured by TEE (TEE-Amp4), ampulla diameter at the level of the aorta measured by TEE, and ampulla length were measured. Pulmonary ostium diameter measured by TEE was 4.1 mm (1.4–8.1), measuring 42% (35–66%) of the TEE-Amp4. Closure methods included the use of an Amplatz canine duct occluder (ACDO) device (27/30) and surgical ligation (3/30). The median ACDO size was 7 mm (3–12). Immediately after ACDO occlusion, TEE-Amp4 and ampulla diameter at the level of the aorta measured by TEE had a median increase of 21% (0–148) and 16% (4–59), respectively. Complications occurred in four dogs (intra-operative atrial fibrillation [2/30], device embolization following ampulla dilation with subsequent ligation [1/30], and postoperative death following PDA rupture with partial ligation [1/30]).

Study Limitations

Potential errors in breed identification and imaging could affect results.

Conclusions

Standard poodle and crossbred dogs can have large or unusually shaped PDAs, with TEE imaging able to provide anatomic information and intra-operative monitoring.

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引用次数: 0

Idiopathic spontaneous intracardiac microbubbles in an adult dog

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-03-12 DOI: 10.1016/j.jvc.2025.03.001

L. Beeby , M. Martinez , E.F. Bode

A four-year-old, female neutered English springer spaniel presented for evaluation of exercise intolerance, panting and lingual cyanosis. Echocardiography revealed a structurally and functionally normal heart with the presence of spontaneous intracardiac microbubbles entering the right side of the heart from the caudal vena cava. A cause for the clinical signs could not be identified; routine blood work, urinalysis and electrocardiography were unremarkable. Testing for tick-borne diseases, clotting times, cardiac biomarkers, thyroid function and basal cortisol were all within normal limits. Faecal samples tested for Clostridium perfringens alpha, beta and epsilon toxins were negative. Genetic conditions including malignant hyperthermia and phosphofructokinase deficiency were excluded. Computed tomography and angiography of the abdomen and thorax revealed no abnormalities or shunting vessels that could explain the origin of the spontaneous intracardiac microbubbles. Previously, microbubbles have only been visualised when intravenous access is present or when purposeful contrast studies are performed. As far as the authors are aware, this is the first case of spontaneous intracardiac microbubbles visualised in the right heart of a dog with no identifiable underlying systemic conditions.

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引用次数: 0

Left ventricular non-compaction cardiomyopathy in eight guinea pigs (Cavia porcellus)

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-02-20 DOI: 10.1016/j.jvc.2025.02.002

K. Kraszewska , I. Janus-Ziółkowska , P.R. Fox , K.E. Schober

Introduction

Left ventricular non-compaction cardiomyopathy (LVNC) is a rare form of myocardial disease in humans, and only three animal case reports have been published. We report on LVNC in eight guinea pigs.

Animals, Materials and Methods

Between 2018 and 2023, LVNC was identified in eight hairless Skinny breed guinea pigs (Cavia porcellus) aged 2–4.5 years that were referred for cardiac evaluation. Physical and echocardiographic examinations were performed. Echocardiographic findings were compared to those of a matched case-control group comprising eight apparently healthy guinea pigs. Seven of the eight animals with LVNC had congestive heart failure. Two underwent necropsy with cardiac histopathological examination.

Results

Four animals had a familial relationship within two litters. The other four were not related. Echocardiographic examination in all affected animals identified regions of left ventricular trabecular, spongy, non-compacted endocardium and endomyocardium. Left ventricular enlargement, systolic dysfunction, and enlargement of the left atrium were noted in seven of eight animals; pericardial effusion was present in four guinea pigs. The seven animals with congestive heart failure were treated with furosemide and pimobendan. Median survival time after diagnosis was 127 days (range: 7–270 days). Postmortem examination was conducted in two of these eight animals and presence of LVNC was confirmed.

Study limitations

Only two guinea pigs underwent necropsy, the gold standard in the diagnosis of LVNC. Thoracic radiographs were not taken and electrocardiography was not performed. Treatment choices were based on criteria used in dogs and cats.

Conclusion

Left ventricular non-compaction cardiomyopathy exists in guinea pigs. Familial relationships among affected animals suggest the possibility of a genetic etiology. Echocardiography was suitable to detect endomyocardial changes consistent with LVNC. Postmortem examination confirmed the LVNC diagnosis with additional involvement of the right ventricle in some animals.

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引用次数: 0

Intra-operative use of transesophageal echocardiography in dogs undergoing interventional procedures for pulmonic stenosis: a case series 在接受肺动脉狭窄介入手术的犬只术中使用经食道超声心动图：一个病例系列

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-02-10 DOI: 10.1016/j.jvc.2025.02.001

S. Sudunagunta, S. Goodrich, F. Sarcinella

Six dogs were presented for interventional treatment of pulmonic stenosis (balloon valvuloplasty or pulmonary stent implantation). Intra-operative transesophageal echocardiography was performed for subjective pulmonary valve assessment and to measure the transpulmonary pressure gradient. Balloon valvuloplasty was performed in two dogs; the remaining four dogs underwent pulmonary stent implantation. The reduction in pressure was assessed after balloon inflation/stent deployment by right heart catheterization and transesophageal echocardiography. In two patients, complete catheterization was not performed, and success was based solely on a reduction in the pressure gradient measured by transesophageal echocardiography. The procedure was completed successfully in all six dogs, with reduction in pressure measured by catheterization ranging from 47.0% to 96.8% (median: 78.6%) in four dogs and 47.3%–85.2% (median: 80.9%) measured by transesophageal echocardiography in all six dogs. No complications associated with transesophageal echocardiography were observed. In this case series, transesophageal echocardiography allowed subjective assessment of the pulmonic valve leaflets and measurement of annular diameter and transpulmonary pressure gradient. The reduction in transpulmonary pressure gradient seen with transesophageal echocardiography was comparable to the reduction documented on catheterization. Further studies are indicated to objectively assess the agreement between transesophageal echocardiography and catheterization measurements, but in these patients, transesophageal echocardiography allowed increased confidence in procedural success.

{"title":"Intra-operative use of transesophageal echocardiography in dogs undergoing interventional procedures for pulmonic stenosis: a case series","authors":"S. Sudunagunta, S. Goodrich, F. Sarcinella","doi":"10.1016/j.jvc.2025.02.001","DOIUrl":"10.1016/j.jvc.2025.02.001","url":null,"abstract":"<div><div>Six dogs were presented for interventional treatment of pulmonic stenosis (balloon valvuloplasty or pulmonary stent implantation). Intra-operative transesophageal echocardiography was performed for subjective pulmonary valve assessment and to measure the transpulmonary pressure gradient. Balloon valvuloplasty was performed in two dogs; the remaining four dogs underwent pulmonary stent implantation. The reduction in pressure was assessed after balloon inflation/stent deployment by right heart catheterization and transesophageal echocardiography. In two patients, complete catheterization was not performed, and success was based solely on a reduction in the pressure gradient measured by transesophageal echocardiography. The procedure was completed successfully in all six dogs, with reduction in pressure measured by catheterization ranging from 47.0% to 96.8% (median: 78.6%) in four dogs and 47.3%–85.2% (median: 80.9%) measured by transesophageal echocardiography in all six dogs. No complications associated with transesophageal echocardiography were observed. In this case series, transesophageal echocardiography allowed subjective assessment of the pulmonic valve leaflets and measurement of annular diameter and transpulmonary pressure gradient. The reduction in transpulmonary pressure gradient seen with transesophageal echocardiography was comparable to the reduction documented on catheterization. Further studies are indicated to objectively assess the agreement between transesophageal echocardiography and catheterization measurements, but in these patients, transesophageal echocardiography allowed increased confidence in procedural success.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"59 ","pages":"Pages 24-30"},"PeriodicalIF":1.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Journal title page and editorial board

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-02-01 DOI: 10.1016/S1760-2734(25)00005-0

引用次数: 0

Reference intervals of two-dimensional speckle tracking–derived endocardial global longitudinal strain analysis in 132 healthy cats 132只健康猫二维斑点追踪衍生心内膜整体纵向应变分析的参考区间。

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-02-01 DOI: 10.1016/j.jvc.2024.11.001

J. Schoebel, J. Friederich, J. Eberhard, E.K. Feldhuetter, G. Wess

Introduction

The assessment of left ventricular myocardial deformation and function by two-dimensional speckle tracking–derived strain analysis is an established method in human cardiology. It also progressively gains recognition in veterinary cardiology in both dogs and cats.

Objectives

The objectives of this study were to create reference intervals for two-dimensional speckle tracking echocardiography (STE)–derived endocardial global longitudinal strain (GLS) in a population of healthy adult cats of different breeds. Influences of heart rate, body weight, and age were investigated.

Animals

A total of 132 healthy, adult cats were included in this study.

Materials and Methods

Left apical two-, three-, and four-chamber views were obtained prospectively for GLS measurements using two-dimensional speckle tracking performed with cardiac performance analysis. Potential influence of body weight, heart rate, and age was analyzed, and the interobserver and intra-observer variability of the measurements was determined.

Results

Endocardial GLS values were not significantly influenced by body weight (P=0.102), heart rate (P=0.144), or age (P=0.075). A reference interval for GLS of −21.18% to −37.50% (±4.12) was determined. The interobserver and intra-observer variability showed excellent agreement.

Discussion and Conclusions

Two-dimensional STE is a feasible technique for the evaluation of cardiac myocardial deformation and systolic function in cats. Showing an excellent interobserver and intra-observer agreement, two-dimensional STE is a promising method for clinical analysis of cardiac deformation in cats.

二维散斑跟踪应变分析评价左室心肌变形和功能是人类心脏病学中一种成熟的方法。它也逐渐在狗和猫的兽医心脏病学中得到认可。目的：本研究的目的是为不同品种的健康成年猫群体的二维斑点跟踪超声心动图（STE）衍生的心内膜整体纵向应变（GLS）创建参考区间。研究了心率、体重和年龄的影响。动物：本研究共纳入132只健康的成年猫。材料和方法：使用二维散斑跟踪和心脏性能分析，前瞻性地获得左心尖二室、三室和四室视图，用于GLS测量。分析了体重、心率和年龄的潜在影响，并确定了观察者之间和观察者内部的测量变异性。结果：心内膜GLS值不受体重（P=0.102）、心率（P=0.144）和年龄（P=0.075）的显著影响。GLS的参考区间为-21.18% ~ -37.50%（±4.12）。观察者之间和观察者内部的可变性表现出极好的一致性。讨论与结论：二维STE是一种评估猫心肌变形和收缩功能的可行技术。二维STE显示了良好的观察者之间和观察者内部的一致性，是一种很有前途的猫心脏变形临床分析方法。

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引用次数: 0

Assessment of heart rate measurements obtained from a smart collar compared to 24-h Holter monitoring in healthy dogs 将智能项圈获得的心率测量值与健康犬的 24 小时 Holter 监测值进行比较评估。

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-02-01 DOI: 10.1016/j.jvc.2024.11.002

T. Gunasekaran, R.A. Sanders

Introduction/Objectives

The primary objective was to compare the 24-h mean heart rate (HR) provided by a smart collar with 24-h ambulatory electrocardiography (Holter) in healthy dogs. The secondary objective was to compare the 2-min HR values between the two methods during periods of activity and rest.

Animals, materials, and methods

Twelve healthy dogs were fitted with both Holter monitors and smart collars. Passing-Bablok regression and Bland-Altman (BA) agreement analysis were used to compare the 24-h mean HR between two methods. The BA analysis for repeated measures and bias plots were used to compare 2-min HR between methods.

Results

The regression analysis showed no significant differential or proportional bias between the methods to estimate 24-h mean HR. The BA analysis showed a mean bias of 2.2 beats per minute (bpm) (95% confidence interval = −0.2, 4.8) with an upper limit of agreement (LOA) of 9.6 bpm (5.1, 14.1) and a lower LOA of −5.1 bpm (−9.5 to −0.6). However, BA analysis of 2-min HR showed poor agreement between methods with wide LOAs at rest and during activity. The smart collar did not provide any HR information for 43% of the total possible recording duration (range = 24%–79%).

Study Limitations and Conclusions

The smart collar can provide a potentially clinically useful estimate of 24-h HR in dogs with normal sinus rhythm. The collar did not provide reliable 2-min HR measurements due to inaccuracies in HR estimation during periods of activity and the inability to report any HR during large periods of the recording.

简介/目标：主要目的是比较智能项圈提供的健康犬 24 小时平均心率（HR）与 24 小时动态心电图（Holter）。次要目标是比较两种方法在活动和休息期间的 2 分钟心率值：12 只健康狗同时安装了 Holter 监测器和智能项圈。使用 Passing-Bablok 回归和 Bland-Altman (BA) 一致性分析比较两种方法的 24 小时平均心率。重复测量的 BA 分析和偏差图用于比较两种方法的 2 分钟心率：结果：回归分析表明，在估算 24 小时平均心率时，两种方法之间没有明显的差异或比例偏差。BA分析显示平均偏差为每分钟2.2次（bpm）（95%置信区间=-0.2，4.8），一致性上限（LOA）为每分钟9.6次（5.1，14.1），LOA下限为每分钟-5.1次（-9.5至-0.6）。然而，对 2 分钟心率的 BA 分析表明，不同方法之间的一致性较差，休息和活动时的 LOA 较大。在可能的总记录时间中，智能项圈有 43% 的时间没有提供任何心率信息（范围 = 24%-79%）：研究局限性和结论：智能项圈可为窦性心律正常的狗提供临床上有用的 24 小时心率估计值。由于在活动期间心率估算不准确，以及在大段记录期间无法报告任何心率，项圈无法提供可靠的 2 分钟心率测量值。

{"title":"Assessment of heart rate measurements obtained from a smart collar compared to 24-h Holter monitoring in healthy dogs","authors":"T. Gunasekaran, R.A. Sanders","doi":"10.1016/j.jvc.2024.11.002","DOIUrl":"10.1016/j.jvc.2024.11.002","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>The primary objective was to compare the 24-h mean heart rate (HR) provided by a smart collar with 24-h ambulatory electrocardiography (Holter) in healthy dogs. The secondary objective was to compare the 2-min HR values between the two methods during periods of activity and rest.</div></div><div><h3>Animals, materials, and methods</h3><div>Twelve healthy dogs were fitted with both Holter monitors and smart collars. Passing-Bablok regression and Bland-Altman (BA) agreement analysis were used to compare the 24-h mean HR between two methods. The BA analysis for repeated measures and bias plots were used to compare 2-min HR between methods.</div></div><div><h3>Results</h3><div>The regression analysis showed no significant differential or proportional bias between the methods to estimate 24-h mean HR. The BA analysis showed a mean bias of 2.2 beats per minute (bpm) (95% confidence interval = −0.2, 4.8) with an upper limit of agreement (LOA) of 9.6 bpm (5.1, 14.1) and a lower LOA of −5.1 bpm (−9.5 to −0.6). However, BA analysis of 2-min HR showed poor agreement between methods with wide LOAs at rest and during activity. The smart collar did not provide any HR information for 43% of the total possible recording duration (range = 24%–79%).</div></div><div><h3>Study Limitations and Conclusions</h3><div>The smart collar can provide a potentially clinically useful estimate of 24-h HR in dogs with normal sinus rhythm. The collar did not provide reliable 2-min HR measurements due to inaccuracies in HR estimation during periods of activity and the inability to report any HR during large periods of the recording.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"57 ","pages":"Pages 58-64"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-operative left atrial size and functions are predictors of left atrial reverse remodelling after mitral valvuloplasty for myxomatous mitral valve disease in dogs 术前左心房大小和功能是二尖瓣粘瘤病二尖瓣成形术后左心房反向重构的预测因素。

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-02-01 DOI: 10.1016/j.jvc.2024.10.007

S. Kawamoto , K. Nakamura , T. Mori , T. Wada , A. Fujiwara , M. Takiguchi

Objectives

The objective of this study was to determine alterations in left atrial size, function, and determinants of left atrial reverse remodelling (LARR) after mitral valvuloplasty (MVP) in dogs with myxomatous mitral valve disease.

Animals

Thirty-seven dogs undergoing MVP were included in this study.

Materials and Methods

Echocardiographic parameters, including left atrial (LA) strain, were evaluated at baseline, during the early postoperative period (within two weeks), and at one and three months postoperatively. Patients were divided into two groups based on the attainment of LARR, defined as a left atrial-to-aortic root ratio (LA:Ao) < 1.6 at three months. The predictors of LARR were analysed using univariate logistic regression analysis.

Results

Left atrial-to-aortic root ratio significantly decreased in the early postoperative period (median: 1.68; lower and upper quartiles: 1.54–1.92) compared to that in baseline (2.41; 2.00–2.80), with a further significant reduction observed at three months (1.46; 1.34–1.63). Left atrial reverse remodelling was achieved in 27 (73%) patients. Baseline left atrial-to-aortic root ratio was higher, and peak atrial longitudinal strain and peak atrial contraction strain (PACS) were lower in the non-LARR group than in the LARR group. Among the baseline parameters, PACS was the strongest predictor of LARR (area under the curve: 0.837).

Conclusions

Following MVP, the LA size decreased in the early postoperative period and continued to decrease over three months of follow-up. A low PACS score was the most reliable predictor of inadequate LARR. Further studies are necessary to determine the relationship between LARR, prognosis, and the optimal timing for surgical intervention.

目的：本研究的目的是确定二尖瓣黏液瘤病犬二尖瓣成形术（MVP）后左房大小、功能和左房反向重构（LARR）的决定因素的改变。动物：37只接受MVP治疗的狗被纳入本研究。材料和方法：在基线、术后早期（2周内）、术后1个月和3个月评估超声心动图参数，包括左心房（LA）应变。根据LARR的达到程度将患者分为两组，LARR定义为左心房与主动脉根比值（LA:Ao）。结果：术后早期左心房与主动脉根比值显著降低(中位数：1.68；下和上四分位数：1.54-1.92)与基线(2.41；2.00-2.80)，在三个月时观察到进一步显著下降(1.46；1.34 - -1.63)。27例（73%）患者实现左心房反向重构。非LARR组左心房与主动脉根基线比值较高，心房纵应变峰和心房收缩应变峰（PACS）均低于LARR组。在基线参数中，PACS是LARR的最强预测因子（曲线下面积：0.837）。结论：MVP术后早期LA大小减小，并在随访3个月后继续减小。低PACS评分是LARR不足最可靠的预测指标。需要进一步的研究来确定LARR、预后和最佳手术时机之间的关系。

{"title":"Pre-operative left atrial size and functions are predictors of left atrial reverse remodelling after mitral valvuloplasty for myxomatous mitral valve disease in dogs","authors":"S. Kawamoto , K. Nakamura , T. Mori , T. Wada , A. Fujiwara , M. Takiguchi","doi":"10.1016/j.jvc.2024.10.007","DOIUrl":"10.1016/j.jvc.2024.10.007","url":null,"abstract":"<div><h3>Objectives</h3><div>The objective of this study was to determine alterations in left atrial size, function, and determinants of left atrial reverse remodelling (LARR) after mitral valvuloplasty (MVP) in dogs with myxomatous mitral valve disease.</div></div><div><h3>Animals</h3><div>Thirty-seven dogs undergoing MVP were included in this study.</div></div><div><h3>Materials and Methods</h3><div>Echocardiographic parameters, including left atrial (LA) strain, were evaluated at baseline, during the early postoperative period (within two weeks), and at one and three months postoperatively. Patients were divided into two groups based on the attainment of LARR, defined as a left atrial-to-aortic root ratio (LA:Ao) < 1.6 at three months. The predictors of LARR were analysed using univariate logistic regression analysis.</div></div><div><h3>Results</h3><div>Left atrial-to-aortic root ratio significantly decreased in the early postoperative period (median: 1.68; lower and upper quartiles: 1.54–1.92) compared to that in baseline (2.41; 2.00–2.80), with a further significant reduction observed at three months (1.46; 1.34–1.63). Left atrial reverse remodelling was achieved in 27 (73%) patients. Baseline left atrial-to-aortic root ratio was higher, and peak atrial longitudinal strain and peak atrial contraction strain (PACS) were lower in the non-LARR group than in the LARR group. Among the baseline parameters, PACS was the strongest predictor of LARR (area under the curve: 0.837).</div></div><div><h3>Conclusions</h3><div>Following MVP, the LA size decreased in the early postoperative period and continued to decrease over three months of follow-up. A low PACS score was the most reliable predictor of inadequate LARR. Further studies are necessary to determine the relationship between LARR, prognosis, and the optimal timing for surgical intervention.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"57 ","pages":"Pages 47-57"},"PeriodicalIF":1.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiuretic hormone concentrations in dogs with heart disease and relationship to serum chloride

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-01-31 DOI: 10.1016/j.jvc.2025.01.007

A.N. Harris , C. Hanner, A. Cooper, R.A. Castro, D.B. Adin

Introduction/objectives

Non-osmotic antidiuretic hormone (ADH) release promotes electrolyte-free water retention in dogs with congestive heart failure (CHF), contributing to low electrolyte concentrations. We hypothesized that dogs with CHF would have higher ADH concentrations than healthy dogs and dogs with preclinical heart disease, and that ADH concentrations would positively correlate to the amount of chloride [Cl⁻] correction but not serum osmolality.

Animals, Materials and Methods

The study population comprised 20 healthy, 20 preclinical, and 20 CHF dogs. Serum electrolytes, serum osmolality, and plasma ADH were measured and compared between groups using the Kruskal–Wallis test. Relationships between ADH and electrolytes, the amount of [Cl⁻] correction, osmolality, and the use of amlodipine and renin-angiotensin-aldosterone system inhibitors were explored with multiple linear regression.

Results

Preclinical (median 6.5 pg/mL; range 1.8 pg/mL–33.8 pg/mL) and CHF (6.7 pg/mL; range 2.0 pg/mL–28.1 pg/mL) dogs had higher ADH concentrations than healthy dogs (median 3.4 pg/mL; range 0.1 pg/mL–6.2 pg/mL) (P=0.004) but there was no difference between preclinical and CHF dogs. Serum ADH was inversely correlated with [Cl⁻] (P=0.026, r_s = −0.287) and c[Cl⁻] (P=0.008, r_s = −0.338). Amlodipine use and [Cl⁻] predicted ADH after controlling for age, weight, use of renin-angiotensin aldosterone inhibitors, and osmolality. There was no significant relationship between ADH and the amount of [Cl⁻] correction, osmolality, or serum sodium.

Discussion

The inverse relationship between ADH and serum [Cl⁻] and the positive relationship with amlodipine use suggests neurohormonal stimulation as a common mechanism.

Uncoupling of ADH from osmolality and serum sodium is consistent with non-osmotic release, which was present even in dogs with preclinical heart disease.

Conclusions

Antidiuretic hormone was elevated in dogs with heart disease but was not a unique feature of advanced heart disease.

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引用次数: 0