首页 > 最新文献

Journal of Veterinary Cardiology最新文献

英文 中文
Retrospective review of the use of hydrochlorothiazide in dogs with myxomatous mitral valve disease and refractory congestive heart failure (American College of Veterinary Cardiology stage D) 氢氯噻嗪用于二尖瓣黏液瘤性疾病和难治性充血性心力衰竭犬的回顾性研究(美国兽医心脏病学会D期)。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-28 DOI: 10.1016/j.jvc.2025.09.005
A. Boscia , A. Galizzi , M. Caccia , V. Caroli , G. Ortiz Diez , R. Toschi Corneliani , I. Spalla

Introduction/Objectives

In dogs with myxomatous mitral valve disease (MMVD) American College of Veterinary Internal Medicine (ACVIM) stage D, hydrochlorothiazide (HCTZ) can be added to achieve sequential nephron blockade. Information on outcome, survival, and complications in this group of patients receiving HCTZ is limited, hence the aim of the present retrospective observational, longitudinal study.

Animals, Materials and Methods

A single-referral-center cohort study was conducted; 25 dogs diagnosed with MMVD stage D receiving HCTZ as part of multimodal treatment of refractory congestive heart failure were included in the study. Data retrieved included cardiac treatment at T0 (when HCTZ was first prescribed) and subsequent visits, available bloodwork, echocardiographic assessment, additional diagnostics, cause of death, and survival time.

Results

Mean starting dose of HCTZ was 0.8 mg/kg every 48 h, with progressive increases (latest mean recorded HCTZ dose: 1.5 mg/kg/day). Azotemia was identified in three dogs at T0 and in 11 dogs following HCTZ addition. Three dogs experienced clinically relevant side effects, resulting in discontinuation of HCTZ in one dog. Twenty dogs died, the majority due to cardiac disease (90). Median survival time of the cohort was 268 days.

Study Limitations

Limitations of this study included the retrospective nature of the study and small sample size.

Conclusions

Although associated with an increase in renal parameters, HCTZ addition at the study dosages appeared clinically tolerated in most dogs with MMVD ACVIM stage D, with a prolonged median survival time for dogs in ACVIM stage D.
简介/目的:在美国兽医内科学会(ACVIM) D期二尖瓣黏液瘤病(MMVD)犬中,可添加氢氯噻嗪(HCTZ)以实现肾素序贯阻断。关于这组接受HCTZ患者的预后、生存和并发症的信息有限,因此本研究的目的是回顾性观察性、纵向研究。动物、材料和方法:采用单转诊中心队列研究;25只被诊断为MMVD D期的狗接受HCTZ作为难治性充血性心力衰竭多模式治疗的一部分纳入研究。检索到的数据包括T0时(首次开HCTZ时)的心脏治疗和随后的就诊、可用的血液检查、超声心动图评估、其他诊断、死亡原因和生存时间。结果:HCTZ平均起始剂量为0.8 mg/kg/ h,并逐渐增加(最新记录的HCTZ平均剂量为1.5 mg/kg/d)。3只狗在T0和11只狗在添加HCTZ后发现氮血症。3只狗出现了临床相关的副作用,导致1只狗停止使用HCTZ。20只狗死亡,大多数死于心脏病(90只)。该队列的中位生存时间为268天。研究局限性:本研究的局限性包括研究的回顾性和小样本量。结论:尽管与肾脏参数增加相关,但在研究剂量下添加HCTZ在大多数患有MMVD ACVIM D期的狗中表现出临床耐受性,并且ACVIM D期狗的中位生存时间延长。
{"title":"Retrospective review of the use of hydrochlorothiazide in dogs with myxomatous mitral valve disease and refractory congestive heart failure (American College of Veterinary Cardiology stage D)","authors":"A. Boscia ,&nbsp;A. Galizzi ,&nbsp;M. Caccia ,&nbsp;V. Caroli ,&nbsp;G. Ortiz Diez ,&nbsp;R. Toschi Corneliani ,&nbsp;I. Spalla","doi":"10.1016/j.jvc.2025.09.005","DOIUrl":"10.1016/j.jvc.2025.09.005","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>In dogs with myxomatous mitral valve disease (MMVD) American College of Veterinary Internal Medicine (ACVIM) stage D, hydrochlorothiazide (HCTZ) can be added to achieve sequential nephron blockade. Information on outcome, survival, and complications in this group of patients receiving HCTZ is limited, hence the aim of the present retrospective observational, longitudinal study.</div></div><div><h3>Animals, Materials and Methods</h3><div>A single-referral-center cohort study was conducted; 25 dogs diagnosed with MMVD stage D receiving HCTZ as part of multimodal treatment of refractory congestive heart failure were included in the study. Data retrieved included cardiac treatment at T0 (when HCTZ was first prescribed) and subsequent visits, available bloodwork, echocardiographic assessment, additional diagnostics, cause of death, and survival time.</div></div><div><h3>Results</h3><div>Mean starting dose of HCTZ was 0.8 mg/kg every 48 h, with progressive increases (latest mean recorded HCTZ dose: 1.5 mg/kg/day). Azotemia was identified in three dogs at T0 and in 11 dogs following HCTZ addition. Three dogs experienced clinically relevant side effects, resulting in discontinuation of HCTZ in one dog. Twenty dogs died, the majority due to cardiac disease (90). Median survival time of the cohort was 268 days.</div></div><div><h3>Study Limitations</h3><div>Limitations of this study included the retrospective nature of the study and small sample size.</div></div><div><h3>Conclusions</h3><div>Although associated with an increase in renal parameters, HCTZ addition at the study dosages appeared clinically tolerated in most dogs with MMVD ACVIM stage D, with a prolonged median survival time for dogs in ACVIM stage D.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"62 ","pages":"Pages 152-163"},"PeriodicalIF":1.3,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of an interactive, stereoscopic three-dimensional viewer to evaluate atrial septal defects in five dogs 应用交互式立体三维观测器评价5只犬房间隔缺损
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-27 DOI: 10.1016/j.jvc.2025.09.006
C.H. Stoner , S. Wesselowski , S.G. Gordon , A.B. Saunders
Definitive closure of atrial septal defects (ASDs) has been reported in dogs utilizing a variety of methods, including device occlusion. We report five dogs with ASD in which multidimensional imaging with computed tomography angiography (CTA) and three-dimensional reconstruction was utilized to assess suitability for device occlusion. Three dogs were initially evaluated for an asymptomatic murmur noted during routine preventative care visits, and two had presenting complaints of mild exercise intolerance. Concurrent congenital heart disease was diagnosed in four of the dogs including pulmonary valve stenosis (n = 2), mitral and tricuspid valve dysplasia (n = 2), and restrictive perimembranous ventricular septal defect (n = 1). Following comprehensive transthoracic echocardiography, ECG-gated CTA was acquired under conscious sedation to characterize ASD anatomy including rim tissue and surrounding structures to determine candidacy for device occlusion. A reconstructed model was viewed with three-dimensional glasses in a mixed reality environment displayed as a stereoscopic object able to be rotated in 360° on a desktop monitor. Inadequate rim tissue was demonstrated in four dogs. Device occlusion was recommended in one dog and successfully performed with a hybrid procedure. Subsequently, balloon pulmonary valvuloplasty was performed. The dog was clinically doing well at 9.1 years of age. The remaining four dogs were clinically doing well (three) or had mild exercise intolerance reported (one) at 4.0–11.5 years of age. This case series demonstrates the utility of stereoscopic models and an interactive mixed reality viewer to assess procedural candidacy for device occlusion in dogs with ASD.
房间隔缺损(ASDs)的最终关闭已报道在狗使用各种方法,包括装置闭塞。我们报告了5只患有ASD的狗,利用计算机断层血管造影(CTA)和三维重建的多维成像来评估设备闭塞的适用性。三只狗最初被评估为在常规预防性护理访问中发现的无症状杂音,两只狗表现出轻度运动不耐受的抱怨。其中4只犬并发先天性心脏病,包括肺动脉瓣狭窄(n = 2)、二尖瓣和三尖瓣发育不良(n = 2)和限制性膜周室间隔缺损(n = 1)。经过全面的经胸超声心动图,在清醒镇静下获得心电图门控CTA,以表征ASD的解剖结构,包括边缘组织和周围结构,以确定设备闭塞的候选性。重建模型在混合现实环境中使用三维眼镜观看,在桌面显示器上显示为可以360°旋转的立体物体。4只狗的边缘组织不足。器械闭塞被推荐在一只狗和成功地执行混合程序。随后行球囊肺动脉瓣成形术。这只狗在9.1岁时临床表现良好。其余4只狗在4.0-11.5岁时临床表现良好(3只)或报告有轻度运动不耐受(1只)。本病例系列展示了立体模型和交互式混合现实观察器的实用性,以评估ASD犬设备闭塞的程序性候选性。
{"title":"Application of an interactive, stereoscopic three-dimensional viewer to evaluate atrial septal defects in five dogs","authors":"C.H. Stoner ,&nbsp;S. Wesselowski ,&nbsp;S.G. Gordon ,&nbsp;A.B. Saunders","doi":"10.1016/j.jvc.2025.09.006","DOIUrl":"10.1016/j.jvc.2025.09.006","url":null,"abstract":"<div><div>Definitive closure of atrial septal defects (ASDs) has been reported in dogs utilizing a variety of methods, including device occlusion. We report five dogs with ASD in which multidimensional imaging with computed tomography angiography (CTA) and three-dimensional reconstruction was utilized to assess suitability for device occlusion. Three dogs were initially evaluated for an asymptomatic murmur noted during routine preventative care visits, and two had presenting complaints of mild exercise intolerance. Concurrent congenital heart disease was diagnosed in four of the dogs including pulmonary valve stenosis (n = 2), mitral and tricuspid valve dysplasia (n = 2), and restrictive perimembranous ventricular septal defect (n = 1). Following comprehensive transthoracic echocardiography, ECG-gated CTA was acquired under conscious sedation to characterize ASD anatomy including rim tissue and surrounding structures to determine candidacy for device occlusion. A reconstructed model was viewed with three-dimensional glasses in a mixed reality environment displayed as a stereoscopic object able to be rotated in 360° on a desktop monitor. Inadequate rim tissue was demonstrated in four dogs. Device occlusion was recommended in one dog and successfully performed with a hybrid procedure. Subsequently, balloon pulmonary valvuloplasty was performed. The dog was clinically doing well at 9.1 years of age. The remaining four dogs were clinically doing well (three) or had mild exercise intolerance reported (one) at 4.0–11.5 years of age. This case series demonstrates the utility of stereoscopic models and an interactive mixed reality viewer to assess procedural candidacy for device occlusion in dogs with ASD.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"62 ","pages":"Pages 164-169"},"PeriodicalIF":1.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suspected neurogenic myocardial stunning following traumatic brain injury in a dog 犬创伤性脑损伤后疑似神经源性心肌休克
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-19 DOI: 10.1016/j.jvc.2025.09.004
A. Machado, O. Belachsen
An eight-year-old male Chihuahua was presented for a cardiac evaluation after sustaining head trauma. New mitral regurgitation, left cardiac dilation, and systolic and diastolic dysfunction were present. Normalisation of cardiac dimensions and function was apparent within 12 days. Findings were consistent with myocardial stunning. The authors hypothesise head trauma–induced neurogenic myocardial stunning, a phenomenon observed in humans after traumatic brain injury but not previously reported in dogs.
一只八岁的雄性吉娃娃在持续头部创伤后接受心脏评估。出现新的二尖瓣返流,左心扩张,收缩和舒张功能障碍。心脏尺寸和功能在12天内明显恢复正常。结果与心肌震惊一致。作者假设是头部外伤引起的神经源性心肌休克,这是一种在人类创伤性脑损伤后观察到的现象,但以前没有在狗身上报道过。
{"title":"Suspected neurogenic myocardial stunning following traumatic brain injury in a dog","authors":"A. Machado,&nbsp;O. Belachsen","doi":"10.1016/j.jvc.2025.09.004","DOIUrl":"10.1016/j.jvc.2025.09.004","url":null,"abstract":"<div><div>An eight-year-old male Chihuahua was presented for a cardiac evaluation after sustaining head trauma. New mitral regurgitation, left cardiac dilation, and systolic and diastolic dysfunction were present. Normalisation of cardiac dimensions and function was apparent within 12 days. Findings were consistent with myocardial stunning. The authors hypothesise head trauma–induced neurogenic myocardial stunning, a phenomenon observed in humans after traumatic brain injury but not previously reported in dogs.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"62 ","pages":"Pages 147-151"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Journal title page and editorial board 杂志标题页和编辑委员会
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-12 DOI: 10.1016/S1760-2734(25)00091-8
{"title":"Journal title page and editorial board","authors":"","doi":"10.1016/S1760-2734(25)00091-8","DOIUrl":"10.1016/S1760-2734(25)00091-8","url":null,"abstract":"","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"61 ","pages":"Page i"},"PeriodicalIF":1.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epicardial pacemaker implantation in a young cat with sick sinus syndrome 心外膜起搏器植入一只患有病态窦性综合征的年轻猫。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-12 DOI: 10.1016/j.jvc.2025.09.003
E.J.Y. Lo, C. Sanchez Villamil, J. Hannabuss, A.G.N. Morey
A one-year-old Abyssinian cat was referred for episodes of vacancy, exaggerated blinking, and intermittent collapse episodes. A 12-lead electrocardiogram (ECG) and ECG telemetry demonstrated sinus bradycardia, sinus pauses, and sinus arrest with a junctional escape rhythm. No infectious agents were identified as a cause of the bradyarrhythmia during systemic disease screening. Findings were consistent with idiopathic sick sinus syndrome. Theophylline therapy did not improve clinical signs or ECG findings. An epicardial pacemaker was placed, which alleviated clinical signs. Pacemaker interrogation after implantation showed minimal use of the pacemaker. This case report highlights the utility of ECG telemetry in describing electrocardiographic findings of sinus arrest, a junctional escape rhythm, and sinus bradycardia in a cat with clinical signs, consistent with sick sinus syndrome which resolved following epicardial pacemaker implantation.
一只一岁的阿比西尼亚猫被认为是空虚,夸张的眨眼和间歇性崩溃的发作。12导联心电图(ECG)和心电图遥测显示窦性心动过缓,窦性暂停,窦性骤停伴交界性逸出节律。在全身性疾病筛查期间,未发现感染性病原体是导致慢性心律失常的原因。结果与特发性病窦综合征一致。茶碱治疗没有改善临床症状或心电图表现。放置心外膜起搏器,减轻了临床症状。起搏器植入后的询问显示起搏器很少使用。本病例报告强调了心电图遥测在描述有临床症状的猫的窦性停搏、交界性逸出节律和窦性心动过缓的心电图表现方面的应用,这些症状与病态窦性综合征一致,在心外膜起搏器植入后消失。
{"title":"Epicardial pacemaker implantation in a young cat with sick sinus syndrome","authors":"E.J.Y. Lo,&nbsp;C. Sanchez Villamil,&nbsp;J. Hannabuss,&nbsp;A.G.N. Morey","doi":"10.1016/j.jvc.2025.09.003","DOIUrl":"10.1016/j.jvc.2025.09.003","url":null,"abstract":"<div><div>A one-year-old Abyssinian cat was referred for episodes of vacancy, exaggerated blinking, and intermittent collapse episodes. A 12-lead electrocardiogram (ECG) and ECG telemetry demonstrated sinus bradycardia, sinus pauses, and sinus arrest with a junctional escape rhythm. No infectious agents were identified as a cause of the bradyarrhythmia during systemic disease screening. Findings were consistent with idiopathic sick sinus syndrome. Theophylline therapy did not improve clinical signs or ECG findings. An epicardial pacemaker was placed, which alleviated clinical signs. Pacemaker interrogation after implantation showed minimal use of the pacemaker. This case report highlights the utility of ECG telemetry in describing electrocardiographic findings of sinus arrest, a junctional escape rhythm, and sinus bradycardia in a cat with clinical signs, consistent with sick sinus syndrome which resolved following epicardial pacemaker implantation.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"62 ","pages":"Pages 106-111"},"PeriodicalIF":1.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient dilated cardiomyopathy phenotype and positive Bartonella serology in a cat 猫一过性扩张型心肌病表型和巴尔通体血清学阳性。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-11 DOI: 10.1016/j.jvc.2025.09.002
B. Ditzler , B. Lozano , C. Jones , M. Henderson , A.B. Saunders
A one-and-a-half-year-old spayed female domestic shorthaired cat, originally obtained as a stray, presented with a two-day history of lethargy, anorexia, and progressive dyspnea. Point-of-care ultrasound showed marked bilateral pleural effusion and a small volume of ascites. Thoracocentesis resulted in the removal of 220 mL of protein poor transudate. Subsequently, a gallop was auscultated and an echocardiogram was performed. Significant findings on echocardiography were a dilated cardiomyopathy phenotype characterized by biventricular eccentric hypertrophy with normal left ventricular diastolic wall thickness and reduced biventricular systolic function with biatrial enlargement. The cat was fed a standard diet and had adequate plasma and whole blood taurine concentration. Infectious disease testing detected Bartonella spp. immunoglobulin G antibodies (1:512) including Bartonella vinsonii of which the cat is not a natural reservoir host. The cat was treated for dilated cardiomyopathy and congestive heart failure with pimobendan, furosemide, and clopidogrel as well as with pradofloxacin and doxycycline for suspected bartonellosis. At 2.5-, 5-, and 9-month rechecks, echocardiogram findings were markedly improved with a reduction in atrial and ventricular chamber enlargement to normal and normal ventricular systolic function and without any further evidence of congestive heart failure. Repeat Bartonella spp. titers were unchanged at 2.5 months. This case describes reverse remodeling of a dilated cardiomyopathy phenotype and resolution of congestive heart failure with discontinuation of cardiac medications in a young cat with suspected Bartonella myocarditis.
一只一岁半的雌性家养短毛猫,最初是作为流浪猫获得的,出现了两天的嗜睡,厌食和进行性呼吸困难的历史。即时超声显示双侧明显胸腔积液和少量腹水。经胸穿刺术取出220毫升蛋白质漏出物。随后,听诊疾驰并进行超声心动图检查。超声心动图的重要发现是扩张型心肌病,其特征是双室偏心肥厚,左室舒张壁厚度正常,双室收缩功能减弱,双房扩大。猫被喂食标准饮食,血浆和全血牛磺酸浓度充足。传染病检测检测到巴尔通体免疫球蛋白G抗体(1:12 12),包括猫不是其天然宿主的文氏巴尔通体。这只猫因扩张性心肌病和充血性心力衰竭接受了匹莫苯丹、呋塞米和氯吡格雷的治疗,并因疑似巴尔通体病接受了普拉多沙星和多西环素的治疗。在2.5个月、5个月和9个月复查时,超声心动图结果明显改善,心房和心室增大至正常和心室收缩功能正常,无进一步充血性心力衰竭的证据。重复巴尔通体滴度在2.5个月时保持不变。本病例描述了扩张型心肌病表型的反向重塑和充血性心力衰竭的解决与停止心脏药物在一个年轻的猫怀疑巴尔通体心肌炎。
{"title":"Transient dilated cardiomyopathy phenotype and positive Bartonella serology in a cat","authors":"B. Ditzler ,&nbsp;B. Lozano ,&nbsp;C. Jones ,&nbsp;M. Henderson ,&nbsp;A.B. Saunders","doi":"10.1016/j.jvc.2025.09.002","DOIUrl":"10.1016/j.jvc.2025.09.002","url":null,"abstract":"<div><div>A one-and-a-half-year-old spayed female domestic shorthaired cat, originally obtained as a stray, presented with a two-day history of lethargy, anorexia, and progressive dyspnea. Point-of-care ultrasound showed marked bilateral pleural effusion and a small volume of ascites. Thoracocentesis resulted in the removal of 220 mL of protein poor transudate. Subsequently, a gallop was auscultated and an echocardiogram was performed. Significant findings on echocardiography were a dilated cardiomyopathy phenotype characterized by biventricular eccentric hypertrophy with normal left ventricular diastolic wall thickness and reduced biventricular systolic function with biatrial enlargement. The cat was fed a standard diet and had adequate plasma and whole blood taurine concentration. Infectious disease testing detected <em>Bartonella</em> spp. immunoglobulin G antibodies (1:512) including <em>Bartonella vinsonii</em> of which the cat is not a natural reservoir host. The cat was treated for dilated cardiomyopathy and congestive heart failure with pimobendan, furosemide, and clopidogrel as well as with pradofloxacin and doxycycline for suspected bartonellosis. At 2.5-, 5-, and 9-month rechecks, echocardiogram findings were markedly improved with a reduction in atrial and ventricular chamber enlargement to normal and normal ventricular systolic function and without any further evidence of congestive heart failure. Repeat <em>Bartonella</em> spp. titers were unchanged at 2.5 months. This case describes reverse remodeling of a dilated cardiomyopathy phenotype and resolution of congestive heart failure with discontinuation of cardiac medications in a young cat with suspected <em>Bartonella</em> myocarditis.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"62 ","pages":"Pages 112-117"},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Echocardiographic description of shunt volume in dogs with patent ductus arteriosus 动脉导管未闭犬分流容积的超声心动图描述。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-08 DOI: 10.1016/j.jvc.2025.09.001
L.S. Köster , A.B. Asbury , C.M. Springer

Introduction/Objectives

Patent ductus arteriosus (PDA) can have a variable clinical course. The aims of this study were to describe Doppler estimates of shunt volume and their association with clinical and echocardiographic abnormalities.

Animals, Materials and Methods

Dogs with a diagnosis of a PDA on echocardiography were included in this study. Signalment, clinical signs, Doppler estimates of shunt volume, and outcome were collected from medical records (June 2020 and 2023) and examined for statistical associations. Groups included hemodynamically insignificant, incidental left-to-right (LR) shunt, left-to-right shunt with congestive heart failure (LCHF), and pulmonary hypertension (PH).

Results

Most dogs had standard LR shunts (76%), 4/4 heart murmur (69%), closing Doppler pattern characterized by—continuous LR shunting and high velocity (71%), and a color flow Doppler pattern—extending to the pulmonic valve (51%). Larger left ventricular chambers and normalized color flow Doppler width (CFDw) (P=0.023) were found in clinical as compared to asymptomatic dogs. Transmitral peak E (E), left ventricular outflow tract velocities, and color flow Doppler pixilation percent fill of the main pulmonary artery (CFD%) were correlated with left chamber dimensions. The LCHF group had a larger CFDw than the LR shunt group (P=0.009), which in turn was larger than that of the PH group (P=0.004). The mean CFD% was larger in the LCHF group (P=0.008) than in the LR-shunt group.

Study Limitations

The retrospective data collection limited standardization of image acquisition. Applicability is further limited by lack of intra-observer and interobserver variability analyses.

Conclusions

Doppler measures of shunt volume in dogs with PDA include E- and left ventricular outflow tract velocities, CFDw, and CFD%.
简介/目的:动脉导管未闭(PDA)有不同的临床病程。本研究的目的是描述多普勒估计分流容量及其与临床和超声心动图异常的关系。动物、材料和方法:本研究纳入超声心动图诊断为PDA的犬。从医疗记录(2020年6月和2023年6月)中收集信号、临床体征、分流体积的多普勒估计和结果,并检查统计关联。各组包括血流动力学不显著、偶发左向右分流、左向右分流合并充血性心力衰竭(LCHF)和肺动脉高压(PH)。结果:大多数狗有标准的左左分流(76%),4/4心脏杂音(69%),以连续左左分流和高流速为特征的闭合多普勒模式(71%),以及延伸到肺动脉瓣的彩色血流多普勒模式(51%)。与无症状犬相比,临床发现左心室增大,归一化彩色血流多普勒宽度(CFDw) (P=0.023)。透射峰E (E)、左室流出道速度、肺动脉彩色血流多普勒像素化填充率(CFD%)与左室尺寸相关。LCHF组CFDw大于LR分流术组(P=0.009),而LCHF组CFDw又大于PH组(P=0.004)。LCHF组的平均CFD%大于lr分流组(P=0.008)。研究局限性:回顾性数据收集限制了图像采集的标准化。由于缺乏观察者内部和观察者之间的可变性分析,适用性进一步受到限制。结论:PDA犬分流容量的多普勒测量包括左室和左室流出道速度、CFDw和CFD%。
{"title":"Echocardiographic description of shunt volume in dogs with patent ductus arteriosus","authors":"L.S. Köster ,&nbsp;A.B. Asbury ,&nbsp;C.M. Springer","doi":"10.1016/j.jvc.2025.09.001","DOIUrl":"10.1016/j.jvc.2025.09.001","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>Patent ductus arteriosus (PDA) can have a variable clinical course. The aims of this study were to describe Doppler estimates of shunt volume and their association with clinical and echocardiographic abnormalities.</div></div><div><h3>Animals, Materials and Methods</h3><div>Dogs with a diagnosis of a PDA on echocardiography were included in this study. Signalment, clinical signs, Doppler estimates of shunt volume, and outcome were collected from medical records (June 2020 and 2023) and examined for statistical associations. Groups included hemodynamically insignificant, incidental left-to-right (LR) shunt, left-to-right shunt with congestive heart failure (LCHF), and pulmonary hypertension (PH).</div></div><div><h3>Results</h3><div>Most dogs had standard LR shunts (76%), 4/4 heart murmur (69%), closing Doppler pattern characterized by—continuous LR shunting and high velocity (71%), and a color flow Doppler pattern—extending to the pulmonic valve (51%). Larger left ventricular chambers and normalized color flow Doppler width (CFDw) (P=0.023) were found in clinical as compared to asymptomatic dogs. Transmitral peak E (E), left ventricular outflow tract velocities, and color flow Doppler pixilation percent fill of the main pulmonary artery (CFD%) were correlated with left chamber dimensions. The LCHF group had a larger CFDw than the LR shunt group (P=0.009), which in turn was larger than that of the PH group (P=0.004). The mean CFD% was larger in the LCHF group (P=0.008) than in the LR-shunt group.</div></div><div><h3>Study Limitations</h3><div>The retrospective data collection limited standardization of image acquisition. Applicability is further limited by lack of intra-observer and interobserver variability analyses.</div></div><div><h3>Conclusions</h3><div>Doppler measures of shunt volume in dogs with PDA include E- and left ventricular outflow tract velocities, CFDw, and CFD%.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"62 ","pages":"Pages 118-131"},"PeriodicalIF":1.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebral small vessel disease in a six-month-old Rottweiler with severe subaortic stenosis 6个月大的罗威纳犬伴有严重主动脉下狭窄的脑血管疾病。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-05 DOI: 10.1016/j.jvc.2025.08.008
M. Croce , F. Marchesotti , O. Domenech , M. Bini , M. Tursi
A six-month-old, 23.5 kg female Rottweiler with severe subaortic stenosis (SAS) was referred for cardiological management due to exercise intolerance. Transthoracic echocardiography revealed severe SAS with a pressure gradient of 130 mmHg. A combined cutting balloon and high-pressure balloon dilation was performed. Postoperatively, the dog developed neurological signs, including depression, absent menace reaction, and reduced facial sensation. Despite further treatment, the clinical signs worsened with blindness and inability to maintain spontaneous breathing before becoming comatose, after which the owner elected for euthanasia.
Necropsy confirmed severe SAS and revealed chronic cerebrocortical necrosis in the brain, with multiple intraparenchymal hemorrhages, vessel congestion, and gliosis. These findings indicated chronic ischemic damage such as that highlighted in cerebral small vessel disease described in humans. This case suggests a potential link between severe SAS and cerebral small vessel disease, similar to findings reported in human patients with severe aortic stenosis. Further research is necessary to explore the connection between SAS in dogs and cerebral perfusion alterations and to determine whether the intervention triggered the symptoms or if they arose independently.
一只6个月大,23.5公斤的雌性罗威纳犬因运动不耐受而患有严重主动脉下狭窄(SAS)。经胸超声心动图显示严重的SAS,压力梯度为130 mmHg。采用切割球囊和高压球囊联合扩张。术后,狗出现神经系统症状,包括抑郁,没有威胁反应,面部感觉减少。尽管进行了进一步的治疗,但临床症状恶化,失明,无法维持自主呼吸,然后陷入昏迷,之后主人选择了安乐死。尸检证实了严重的SAS,并显示慢性脑皮质坏死,伴有多发性脑实质内出血、血管充血和胶质细胞增生。这些发现表明慢性缺血性损伤,如人类脑血管疾病中所描述的。该病例提示严重SAS与脑血管疾病之间存在潜在联系,类似于在人类严重主动脉瓣狭窄患者中报道的结果。需要进一步的研究来探索狗的SAS与脑灌注改变之间的联系,并确定干预是引发症状还是独立出现的。
{"title":"Cerebral small vessel disease in a six-month-old Rottweiler with severe subaortic stenosis","authors":"M. Croce ,&nbsp;F. Marchesotti ,&nbsp;O. Domenech ,&nbsp;M. Bini ,&nbsp;M. Tursi","doi":"10.1016/j.jvc.2025.08.008","DOIUrl":"10.1016/j.jvc.2025.08.008","url":null,"abstract":"<div><div>A six-month-old, 23.5 kg female Rottweiler with severe subaortic stenosis (SAS) was referred for cardiological management due to exercise intolerance. Transthoracic echocardiography revealed severe SAS with a pressure gradient of 130 mmHg. A combined cutting balloon and high-pressure balloon dilation was performed. Postoperatively, the dog developed neurological signs, including depression, absent menace reaction, and reduced facial sensation. Despite further treatment, the clinical signs worsened with blindness and inability to maintain spontaneous breathing before becoming comatose, after which the owner elected for euthanasia.</div><div>Necropsy confirmed severe SAS and revealed chronic cerebrocortical necrosis in the brain, with multiple intraparenchymal hemorrhages, vessel congestion, and gliosis. These findings indicated chronic ischemic damage such as that highlighted in cerebral small vessel disease described in humans. This case suggests a potential link between severe SAS and cerebral small vessel disease, similar to findings reported in human patients with severe aortic stenosis. Further research is necessary to explore the connection between SAS in dogs and cerebral perfusion alterations and to determine whether the intervention triggered the symptoms or if they arose independently.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"62 ","pages":"Pages 141-146"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heart failure associated with minoxidil intoxication in a cat 猫因米诺地尔中毒引起的心力衰竭。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-05 DOI: 10.1016/j.jvc.2025.08.006
C. Ferri, O. Dossin, V. Gouni
A 13-month-old female spayed Russian blue cat was presented for acute respiratory distress. Thoracic radiographs revealed signs of left-sided congestive heart failure with pulmonary oedema, and the echocardiogram showed left ventricular myocardial thickening and concurrent left atrial dilation. In the first hours following admission, in addition to the classic management of congestive heart failure, dobutamine was used because of hypotension. The cat was discharged five days after admission with a prescription of furosemide 1.11 mg/kg PO q 12 h and pimobendan 0.15 mg/kg PO q 12 h. An echocardiographic follow-up, one month later, showed normalisation of the left ventricular walls and atrial size, justifying a gradual withdrawal of drugs. Eight months later, the cat experienced recurrence of clinical signs. Thoracic radiographs suggested a relapsing pulmonary oedema. The echocardiogram showed again a hypertrophic phenotype with moderate left atrial dilation. The cat was hospitalised, and the case was treated similarly to the first episode. Cardiac troponin I was increased to 9.89 ng/mL [<0.2 ng/mL]. Infectious disease tests were negative. Two weeks later, echocardiography showed again normalisation of left ventricular walls and atrial diameter. Treatments were gradually stopped, and subsequent echocardiographic checks showed no abnormalities. After the resolution of the second episode, it was noted that both respiratory distress events appeared after contact with a family member who was using minoxidil to treat androgenic alopecia and whose hair the cat had insistently licked. Minoxidil intoxication was retrospectively considered a likely contributor to these episodes of transient myocardial thickening associated with congestive heart failure.
一只13个月大的雌性绝育俄罗斯蓝猫出现急性呼吸窘迫。胸片显示左侧充血性心力衰竭伴肺水肿的征象,超声心动图显示左室心肌增厚并伴有左房扩张。在入院后的最初几个小时,除了典型的充血性心力衰竭治疗外,由于低血压而使用多巴酚丁胺。入院后5天,猫出院,处方速尿1.11 mg/kg PO q 12 h,匹莫苯丹0.15 mg/kg PO q 12 h。1个月后超声心动图随访显示左心室壁和心房大小恢复正常,证明逐渐停药是合理的。8个月后,猫再次出现临床症状。胸片提示肺水肿复发。超声心动图再次显示肥厚表型伴中度左心房扩张。这只猫被送进医院,该病例的治疗与第一次发作类似。心肌肌钙蛋白I升高至9.89 ng/mL [
{"title":"Heart failure associated with minoxidil intoxication in a cat","authors":"C. Ferri,&nbsp;O. Dossin,&nbsp;V. Gouni","doi":"10.1016/j.jvc.2025.08.006","DOIUrl":"10.1016/j.jvc.2025.08.006","url":null,"abstract":"<div><div>A 13-month-old female spayed Russian blue cat was presented for acute respiratory distress. Thoracic radiographs revealed signs of left-sided congestive heart failure with pulmonary oedema, and the echocardiogram showed left ventricular myocardial thickening and concurrent left atrial dilation. In the first hours following admission, in addition to the classic management of congestive heart failure, dobutamine was used because of hypotension. The cat was discharged five days after admission with a prescription of furosemide 1.11 mg/kg PO q 12 h and pimobendan 0.15 mg/kg PO q 12 h. An echocardiographic follow-up, one month later, showed normalisation of the left ventricular walls and atrial size, justifying a gradual withdrawal of drugs. Eight months later, the cat experienced recurrence of clinical signs. Thoracic radiographs suggested a relapsing pulmonary oedema. The echocardiogram showed again a hypertrophic phenotype with moderate left atrial dilation. The cat was hospitalised, and the case was treated similarly to the first episode. Cardiac troponin I was increased to 9.89 ng/mL [&lt;0.2 ng/mL]. Infectious disease tests were negative. Two weeks later, echocardiography showed again normalisation of left ventricular walls and atrial diameter. Treatments were gradually stopped, and subsequent echocardiographic checks showed no abnormalities. After the resolution of the second episode, it was noted that both respiratory distress events appeared after contact with a family member who was using minoxidil to treat androgenic alopecia and whose hair the cat had insistently licked. Minoxidil intoxication was retrospectively considered a likely contributor to these episodes of transient myocardial thickening associated with congestive heart failure.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"62 ","pages":"Pages 99-105"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular images: long-term electrocardiogram assessment of ventricular modulated parasystole in a 17-month-old dog 心血管图像:一个17个月大的狗的心室调节性副收缩的长期心电图评估
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2025-09-05 DOI: 10.1016/j.jvc.2025.08.007
V. Saponaro , J.-L. Cadoré , M. Dhunputh
A 17-month-old male Staffordshire bull terrier dog was referred in order to assess an asymptomatic arrhythmia. A 5-min electrocardiogram and 24-h Holter monitor recording revealed the following criteria for ventricular parasystole (VP): mathematically related interectopic intervals, varying coupling intervals of ventricular complexes with sinus complexes, and the presence of fusion complexes. The effect of modulation of the VP cycle length by the sinus rhythm was highlighted on the Holter monitor recording. As the dog did not present with clinical signs and the arrhythmia was judged benign, treatment was not prescribed. The veterinary literature about VP is quite poor. A few case reports exist, all without an association with cardiac disease and any evidence of usefulness of an anti-arrhythmic treatment. A long period (more than a short electrocardiogram) is advised in order to definitively diagnose VP and to rule out malignant arrhythmia.
一个17个月大的雄性斯塔福德郡斗牛犬被提及,以评估无症状心律失常。5分钟心电图和24小时动态心电图记录显示心室副收缩(VP)的以下标准:数学上相关的异位间隔,心室复合体与窦性复合体的不同耦合间隔,以及融合复合体的存在。窦性心律对VP周期长度的调节作用在霍尔特监测记录中得到了突出显示。由于狗没有表现出临床症状,心律失常被判定为良性,所以没有进行治疗。关于副流行性腮腺炎的兽医文献很少。存在少数病例报告,均与心脏疾病无关,也没有任何证据表明抗心律失常治疗有用。为了明确诊断VP和排除恶性心律失常,建议长时间(多于短时间)心电图。
{"title":"Cardiovascular images: long-term electrocardiogram assessment of ventricular modulated parasystole in a 17-month-old dog","authors":"V. Saponaro ,&nbsp;J.-L. Cadoré ,&nbsp;M. Dhunputh","doi":"10.1016/j.jvc.2025.08.007","DOIUrl":"10.1016/j.jvc.2025.08.007","url":null,"abstract":"<div><div>A 17-month-old male Staffordshire bull terrier dog was referred in order to assess an asymptomatic arrhythmia. A 5-min electrocardiogram and 24-h Holter monitor recording revealed the following criteria for ventricular parasystole (VP): mathematically related interectopic intervals, varying coupling intervals of ventricular complexes with sinus complexes, and the presence of fusion complexes. The effect of modulation of the VP cycle length by the sinus rhythm was highlighted on the Holter monitor recording. As the dog did not present with clinical signs and the arrhythmia was judged benign, treatment was not prescribed. The veterinary literature about VP is quite poor. A few case reports exist, all without an association with cardiac disease and any evidence of usefulness of an anti-arrhythmic treatment. A long period (more than a short electrocardiogram) is advised in order to definitively diagnose VP and to rule out malignant arrhythmia.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"62 ","pages":"Pages 94-98"},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Veterinary Cardiology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1