Journal of Veterinary Cardiology最新文献

英文中文

Effect of trazodone on heart rate, heart rate variability, and QT-intervals in dogs 曲唑酮对犬心率、心率变异性和qt间隔的影响

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-06-12 DOI: 10.1016/j.jvc.2025.06.004

V.T. Silvia , T.C. DeFrancesco , K.R. Love , S.P. Tou , B.W. Keene

Introduction/Objectives

To determine the effect of trazodone and placebo on heart rate (HR), heart rate variability (HRV), and QT intervals (QTi) in dogs after oral administration of trazodone or placebo.

Animals, Materials and Methods

Twenty healthy adult client-owned dogs were included in the study. Dogs were randomized in a double-blind, placebo-controlled crossover trial. Dogs received trazodone (6 mg/kg q 8 h) or placebo for 24 h, during which a 24-h ambulatory electrocardiogram (ECG) (Holter) was recorded. Diagnostic ECGs and clinician-assessed behavior scores were obtained before and after the 24-h study period. Owners also scored the dog's behavior changes during each of the 24-h study periods. Following a minimum one-week washout period, dogs received the alternate study drug, and all procedures were repeated. Linear and mixed models were used for statistical analyses.

Results

Dogs receiving trazodone had higher average HRs (P=0.035), higher minimum HRs (P<0.001), and reduced HRV parameters (P<0.001) on the Holter recordings. Electrocardiogram-derived QTi was not different between groups. Dogs receiving trazodone appeared calmer based on owner assessments (P<0.001) and behavior scores (P=0.006).

Study Limitations

Blood pressure and trazodone blood levels were not measured, making it impossible to determine the effect of these variables on the HR and ECG findings.

Conclusions

Trazodone increased HR and decreased HRV. Possible explanations include a previously described anticholinergic effect or a possible decrease in blood pressure causing a reflex response. No demonstrable effect on QTi was identified in this cohort of healthy dogs using standard trazodone dosing.

前言/目的探讨曲唑酮和安慰剂对口服曲唑酮或安慰剂后犬心率（HR）、心率变异性（HRV）和QT间期（QTi）的影响。动物、材料和方法20只健康的成年客户拥有的狗被纳入研究。在一项双盲、安慰剂对照的交叉试验中，狗被随机分组。狗接受曲唑酮（6 mg/kg q 8 h）或安慰剂治疗24小时，期间记录24小时动态心电图（Holter）。在24小时研究前后分别获得诊断性心电图和临床评估的行为评分。主人还对狗在24小时研究期间的行为变化进行了评分。在至少一周的洗脱期后，狗接受替代研究药物，并重复所有程序。采用线性和混合模型进行统计分析。结果曲唑酮组狗的平均心率（P=0.035）、最小心率（P < 0.001）和动态心电图HRV参数（P < 0.001）均显著升高。心电图衍生的QTi在两组间无差异。根据饲主评估（P<0.001）和行为评分（P=0.006），接受曲唑酮治疗的狗显得更平静。研究局限性：没有测量血压和曲唑酮水平，因此无法确定这些变量对HR和ECG结果的影响。结论司唑酮可提高心率，降低HRV。可能的解释包括先前描述的抗胆碱能作用或可能引起反射反应的血压降低。在使用标准曲唑酮剂量的健康犬群中，未发现对QTi的明显影响。

{"title":"Effect of trazodone on heart rate, heart rate variability, and QT-intervals in dogs","authors":"V.T. Silvia , T.C. DeFrancesco , K.R. Love , S.P. Tou , B.W. Keene","doi":"10.1016/j.jvc.2025.06.004","DOIUrl":"10.1016/j.jvc.2025.06.004","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>To determine the effect of trazodone and placebo on heart rate (HR), heart rate variability (HRV), and QT intervals (QTi) in dogs after oral administration of trazodone or placebo.</div></div><div><h3>Animals, Materials and Methods</h3><div>Twenty healthy adult client-owned dogs were included in the study. Dogs were randomized in a double-blind, placebo-controlled crossover trial. Dogs received trazodone (6 mg/kg q 8 h) or placebo for 24 h, during which a 24-h ambulatory electrocardiogram (ECG) (Holter) was recorded. Diagnostic ECGs and clinician-assessed behavior scores were obtained before and after the 24-h study period. Owners also scored the dog's behavior changes during each of the 24-h study periods. Following a minimum one-week washout period, dogs received the alternate study drug, and all procedures were repeated. Linear and mixed models were used for statistical analyses.</div></div><div><h3>Results</h3><div>Dogs receiving trazodone had higher average HRs (P=0.035), higher minimum HRs (P<0.001), and reduced HRV parameters (P<0.001) on the Holter recordings. Electrocardiogram-derived QTi was not different between groups. Dogs receiving trazodone appeared calmer based on owner assessments (P<0.001) and behavior scores (P=0.006).</div></div><div><h3>Study Limitations</h3><div>Blood pressure and trazodone blood levels were not measured, making it impossible to determine the effect of these variables on the HR and ECG findings.</div></div><div><h3>Conclusions</h3><div>Trazodone increased HR and decreased HRV. Possible explanations include a previously described anticholinergic effect or a possible decrease in blood pressure causing a reflex response. No demonstrable effect on QTi was identified in this cohort of healthy dogs using standard trazodone dosing.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"61 ","pages":"Pages 20-28"},"PeriodicalIF":1.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atrial depolarization electrocardiographic features during orthodromic atrioventricular reciprocating tachycardia mediated by right-sided accessory pathway in the dog 犬右侧副通路介导的房室往复式心动过速的心房去极化心电图特征

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-06-06 DOI: 10.1016/j.jvc.2025.06.001

A. Maffei , M. Perego , D. Cavallini , R. Santilli

Introduction/Objectives

Electrocardiographic features of atrial depolarization (AD) during orthodromic atrioventricular reciprocating tachycardia (OAVRT) have been widely studied to localize accessory pathways (APs) in humans. The aim of this study was to determine whether AD characteristics might also be used to determine AP anatomical sites in dogs.

Animals, Materials and Methods

Clinical records for 83 dogs that underwent electrophysiologic studies for AP ablation were retrospectively analyzed. Accessory pathways were classified into three groups according to localization: right anterior (RA, 13.3%), right postero-septal (RPS, 36.1%), and right posterior (RP, 50.6%). Electrocardiographic characteristics of AD (duration, amplitude, and axis) and OAVRT (AD-AD, peak of R wave - atrial depolarization (R-AD)/atrial depolarization - peak of R wave (AD-R), peak to peak of R wave (RR) interval, and QT duration) were analyzed in all 12 leads.

Results

Mean AD duration in RA, RPS, and RP was 48.0 ± 10.3 ms, 46.1 ± 10.6 ms, and 47.1 ± 10.2 ms, respectively, and the mean amplitude was −0.25 ± 0.12 mV, −0.28 ± 0.20 mV, and −0.28 ± 0.18 mV, respectively. The median electrical axis on the frontal plane was −90.0° (interquartile range [IQR]: 26.5° in RA, 9.4° in RPS, and 13.9° in RP). The median AD-R, mean R-AD intervals, and mean R-AD/AD-R were 140.0 ms (IQR: 34.5 ms), 72.0 ± 19.3 ms, and 0.50 ± 0.14 in RA; 138.0 ms (IQR: 33.0 ms), 76.5 ± 13.6 ms, and 0.55 ± 0.15 in RPS; and 121.0 ms (IQR: 20.0 ms), 74.1 ± 11.7 ms, and 0.59 ± 0.15 in RP. No others statistically significant differences in electrocardiographic parameters were found.

Study Limitations

Identification of ADs in some dogs was not straightforward, and thoracic conformation differences may have affected AD measurements.

Conclusions

Electrocardiographic features of AD during OAVRT are not useful for localizing right-sided APs in dogs.

导读/目的在人类正畸型房室往复式心动过速（OAVRT）期间心房去极化（AD）的心电图特征已经被广泛研究以定位辅助通路（APs）。本研究的目的是确定AD特征是否也可以用于确定狗的AP解剖部位。动物、材料和方法回顾性分析83只接受AP消融电生理检查的犬的临床记录。附属通路根据定位可分为3组：右前路（RA, 13.3%）、右后间隔（RPS, 36.1%）和右后路（RP, 50.6%）。分析12例导联AD的心电图特征（持续时间、振幅、轴向）和OAVRT (AD-AD、R波峰-心房去极化（R-AD)/心房去极化-R波峰（AD-R）、R波峰间期（RR）、QT间期）。结果RA、RPS、RP组平均AD持续时间分别为48.0±10.3 ms、46.1±10.6 ms和47.1±10.2 ms，平均振幅分别为- 0.25±0.12 mV、- 0.28±0.20 mV和- 0.28±0.18 mV。额平面电轴中位数为- 90.0°（四分位间距[IQR]: RA为26.5°，RPS为9.4°，RP为13.9°）。RA的中位AD-R、平均R-AD间隔和平均R-AD/AD-R分别为140.0 ms （IQR: 34.5 ms）、72.0±19.3 ms和0.50±0.14；RPS分别为138.0 ms （IQR: 33.0 ms）、76.5±13.6 ms和0.55±0.15 ms；和121.0 ms (IQR: 20.0 ms), 74.1±11.7 ms, 0.59±0.15的RP。在心电图参数方面没有发现其他统计学上的显著差异。研究局限性：在一些狗身上识别AD并不简单，胸廓构象的差异可能会影响AD的测量。结论OAVRT时AD的心电图特征对犬右侧APs的定位没有帮助。

{"title":"Atrial depolarization electrocardiographic features during orthodromic atrioventricular reciprocating tachycardia mediated by right-sided accessory pathway in the dog","authors":"A. Maffei , M. Perego , D. Cavallini , R. Santilli","doi":"10.1016/j.jvc.2025.06.001","DOIUrl":"10.1016/j.jvc.2025.06.001","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>Electrocardiographic features of atrial depolarization (AD) during orthodromic atrioventricular reciprocating tachycardia (OAVRT) have been widely studied to localize accessory pathways (APs) in humans. The aim of this study was to determine whether AD characteristics might also be used to determine AP anatomical sites in dogs.</div></div><div><h3>Animals, Materials and Methods</h3><div>Clinical records for 83 dogs that underwent electrophysiologic studies for AP ablation were retrospectively analyzed. Accessory pathways were classified into three groups according to localization: right anterior (RA, 13.3%), right postero-septal (RPS, 36.1%), and right posterior (RP, 50.6%). Electrocardiographic characteristics of AD (duration, amplitude, and axis) and OAVRT (AD-AD, peak of R wave - atrial depolarization (R-AD)/atrial depolarization - peak of R wave (AD-R), peak to peak of R wave (RR) interval, and QT duration) were analyzed in all 12 leads.</div></div><div><h3>Results</h3><div>Mean AD duration in RA, RPS, and RP was 48.0 ± 10.3 ms, 46.1 ± 10.6 ms, and 47.1 ± 10.2 ms, respectively, and the mean amplitude was −0.25 ± 0.12 mV, −0.28 ± 0.20 mV, and −0.28 ± 0.18 mV, respectively. The median electrical axis on the frontal plane was −90.0° (interquartile range [IQR]: 26.5° in RA, 9.4° in RPS, and 13.9° in RP). The median AD-R, mean R-AD intervals, and mean R-AD/AD-R were 140.0 ms (IQR: 34.5 ms), 72.0 ± 19.3 ms, and 0.50 ± 0.14 in RA; 138.0 ms (IQR: 33.0 ms), 76.5 ± 13.6 ms, and 0.55 ± 0.15 in RPS; and 121.0 ms (IQR: 20.0 ms), 74.1 ± 11.7 ms, and 0.59 ± 0.15 in RP. No others statistically significant differences in electrocardiographic parameters were found.</div></div><div><h3>Study Limitations</h3><div>Identification of ADs in some dogs was not straightforward, and thoracic conformation differences may have affected AD measurements.</div></div><div><h3>Conclusions</h3><div>Electrocardiographic features of AD during OAVRT are not useful for localizing right-sided APs in dogs.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"61 ","pages":"Pages 10-19"},"PeriodicalIF":1.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Occurrence and distribution of left ventricular bands and normal anatomical features in 78 feline hearts” [J Vet Cardiol 59 (2025) 81–92] “78只猫心脏左心室带的发生、分布及正常解剖特征”的更正[J Vet Cardiol 59 (2025) 81-92]

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-06-02 DOI: 10.1016/j.jvc.2025.05.001

N. Kiessling , S. Rørvig , J. Häggström

引用次数: 0

Journal title page and editorial board 杂志标题页和编辑委员会

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-06-01 DOI: 10.1016/S1760-2734(25)00049-9

引用次数: 0

Accuracy of visually estimated left heart size by echocardiography in dogs with myxomatous mitral valve disease 超声心动图对二尖瓣黏液瘤病犬左心大小的目测准确性

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-05-28 DOI: 10.1016/j.jvc.2025.05.010

R. Baba , D. Ito , T. Toyofuku , H. Ichihashi , N. Arizuka , M. Okada

Introduction/Objectives

The aim of this study was to assess the correlation between visual estimation of left heart size and conventional echocardiographic measurements in dogs with myxomatous mitral valve disease (MMVD).

Animals, Materials and methods

Seventy dogs with various stages of myxomatous mitral valve disease were retrospectively enrolled. Five investigators (two cardiologists and three non-cardiologists) received brief training before visually evaluating the left atrium-to-aortic ratio (LA:AO) and the presence of left ventricular enlargement using right parasternal long-axis five-chamber and basal short-axis echocardiographic videos. Correlations between visually estimated and conventionally measured LA:AOs were assessed using linear regression and Spearman's rank correlation. Interobserver agreement was evaluated using the intraclass correlation coefficient. Agreement in identifying left ventricular enlargement was assessed using the Fleiss Kappa coefficient.

Results

A strong correlation was found between visual estimation and conventional measurements of LA:AO (r = 0.89; ρ = 0.90; P<0.001). Interobserver agreement for LA:AO visual estimation was good (intraclass correlation coefficient = 0.76; 95% confidence interval: 0.65–0.84). Agreement between visual and conventional evaluation of left ventricular size was moderate (Fleiss Kappa = 0.50).

Study Limitations

Limitations include the use of high-quality images obtained by a cardiologist, the predominance of small-breed dogs, and the use of a non-standard imaging view for left ventricular internal dimension at end-diastole normalized to body weight calculation.

Conclusions

Visual estimation demonstrated strong correlation with quantitative LA:AO measurements and moderate agreement for left ventricular size. It may be a useful tool in emergency or primary care settings when conventional echocardiography is not feasible.

本研究的目的是评估二尖瓣黏液瘤病（MMVD）犬左心尺寸的目测值与常规超声心动图测量值之间的相关性。动物、材料和方法对70只不同分期的二尖瓣黏液瘤病犬进行回顾性研究。五名研究人员（两名心脏病专家和三名非心脏病专家）接受了简短的培训，然后使用右胸骨旁长轴五室和基底短轴超声心动图视频视觉评估左心房与主动脉比（LA:AO）和左心室扩大的存在。使用线性回归和Spearman秩相关评估视觉估计和常规测量的LA:AOs之间的相关性。使用类内相关系数评估观察者间的一致性。使用Fleiss Kappa系数评估左心室增大的一致性。结果LA:AO的目测值与常规测量值有较强的相关性(r = 0.89；ρ = 0.90；术中,0.001)。LA:AO视觉估计的观察者间一致性较好(类内相关系数= 0.76；95%置信区间：0.65-0.84)。目测与常规左心室大小的一致性中等（Fleiss Kappa = 0.50）。研究的局限性包括使用由心脏病专家获得的高质量图像，小型犬的优势，以及使用非标准的舒张末期左心室内部尺寸归一化的体重计算成像视图。结论目测结果与定量LA:AO测量结果有较强的相关性，左心室大小与目测结果有中等程度的一致性。它可能是一个有用的工具，在急诊或初级保健设置时，传统的超声心动图是不可行的。

{"title":"Accuracy of visually estimated left heart size by echocardiography in dogs with myxomatous mitral valve disease","authors":"R. Baba , D. Ito , T. Toyofuku , H. Ichihashi , N. Arizuka , M. Okada","doi":"10.1016/j.jvc.2025.05.010","DOIUrl":"10.1016/j.jvc.2025.05.010","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>The aim of this study was to assess the correlation between visual estimation of left heart size and conventional echocardiographic measurements in dogs with myxomatous mitral valve disease (MMVD).</div></div><div><h3>Animals, Materials and methods</h3><div>Seventy dogs with various stages of myxomatous mitral valve disease were retrospectively enrolled. Five investigators (two cardiologists and three non-cardiologists) received brief training before visually evaluating the left atrium-to-aortic ratio (LA:AO) and the presence of left ventricular enlargement using right parasternal long-axis five-chamber and basal short-axis echocardiographic videos. Correlations between visually estimated and conventionally measured LA:AOs were assessed using linear regression and Spearman's rank correlation. Interobserver agreement was evaluated using the intraclass correlation coefficient. Agreement in identifying left ventricular enlargement was assessed using the Fleiss Kappa coefficient.</div></div><div><h3>Results</h3><div>A strong correlation was found between visual estimation and conventional measurements of LA:AO (r = 0.89; ρ = 0.90; P<0.001). Interobserver agreement for LA:AO visual estimation was good (intraclass correlation coefficient = 0.76; 95% confidence interval: 0.65–0.84). Agreement between visual and conventional evaluation of left ventricular size was moderate (Fleiss Kappa = 0.50).</div></div><div><h3>Study Limitations</h3><div>Limitations include the use of high-quality images obtained by a cardiologist, the predominance of small-breed dogs, and the use of a non-standard imaging view for left ventricular internal dimension at end-diastole normalized to body weight calculation.</div></div><div><h3>Conclusions</h3><div>Visual estimation demonstrated strong correlation with quantitative LA:AO measurements and moderate agreement for left ventricular size. It may be a useful tool in emergency or primary care settings when conventional echocardiography is not feasible.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"61 ","pages":"Pages 1-9"},"PeriodicalIF":1.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short- and long-term effects of hydrochlorothiazide in dogs with relapsing congestive heart failure due to myxomatous mitral valve disease: a retrospective analysis of 38 cases 氢氯噻嗪对二尖瓣黏液瘤性疾病所致复发性充血性心力衰竭犬的短期和长期影响：38例回顾性分析

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-05-24 DOI: 10.1016/j.jvc.2025.05.009

G. Romito , C. Mazzoldi , L. Calebotta , P. Castagna , N.G. Pelle , C. Valente , H. Poser , C. Guglielmini

Introduction/Objectives

Information on the use of hydrochlorothiazide (HCTZ) in dogs with relapsing congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD) is limited. Therefore, the aim of this study was to provide data on HCTZ's short- and long-term effects in canine MMVD.

Animals, materials, and methods

Signalment, clinical, diagnostic, therapeutic, and outcome data of dogs with relapsing CHF due to MMVD treated with HCTZ were retrospectively reviewed. The initial time point was the day HCTZ was introduced for a CHF relapse. Optimized criteria were used to determine the appropriate timings for evaluating HCTZ's short-term effects on laboratory and echocardiographic variables and its long-term impact on CHF management.

Results

Thirty-eight dogs were included. The initial median dose of HCTZ was 0.8 mg/kg/die. At a median of seven days after HCTZ prescription, creatinine, urea, and total calcium levels significantly increased, while sodium and potassium levels significantly decreased (P: from 0.045 to <0.0001). While no dog developed severe electrolyte abnormalities, some dogs showed severe increases in creatinine and urea. After a median of 95 days, no significant echocardiographic changes developed (P: from 0.74 to 0.13). Episodes of CHF were more frequent before (median: one every 68 days) than after (median: one every 124 days) HCTZ prescription (P=0.006).

Study limitations

The study limitations included the retrospective design of the study; not all dogs were included both in the short- and long-term analysis.

Conclusions

In canine MMVD, HCTZ is useful in long-term management of relapsing CHF. However, in the short term, HCTZ can cause laboratory abnormalities, primarily increased creatinine and urea.

介绍/目的氢氯噻嗪（HCTZ）在二尖瓣黏液瘤病（MMVD）所致复发性充血性心力衰竭（CHF）犬中的应用信息有限。因此，本研究的目的是提供HCTZ对犬MMVD的短期和长期影响的数据。动物、材料和方法回顾性回顾了经HCTZ治疗的MMVD所致CHF复发犬的信号、临床、诊断、治疗和结局数据。初始时间点为CHF复发时引入HCTZ的当天。采用优化的标准来确定适当的时机，以评估HCTZ对实验室和超声心动图变量的短期影响及其对CHF管理的长期影响。结果共纳入38只犬。HCTZ初始中位剂量为0.8 mg/kg/只。在HCTZ处方后的中位7天，肌酐、尿素和总钙水平显著升高，钠和钾水平显著降低（P值从0.045降至0.0001）。虽然没有狗出现严重的电解质异常，但一些狗显示肌酐和尿素严重增加。中位95天后，超声心动图无明显变化（P值从0.74到0.13）。HCTZ处方前（中位数：每68天1次）比处方后（中位数：每124天1次）CHF发作更频繁（P=0.006）。研究局限性研究的局限性包括研究的回顾性设计；并不是所有的狗都被包括在短期和长期的分析中。结论在犬MMVD中，HCTZ可用于长期治疗复发性CHF。然而，在短期内，HCTZ可引起实验室异常，主要是肌酐和尿素升高。

{"title":"Short- and long-term effects of hydrochlorothiazide in dogs with relapsing congestive heart failure due to myxomatous mitral valve disease: a retrospective analysis of 38 cases","authors":"G. Romito , C. Mazzoldi , L. Calebotta , P. Castagna , N.G. Pelle , C. Valente , H. Poser , C. Guglielmini","doi":"10.1016/j.jvc.2025.05.009","DOIUrl":"10.1016/j.jvc.2025.05.009","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>Information on the use of hydrochlorothiazide (HCTZ) in dogs with relapsing congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD) is limited. Therefore, the aim of this study was to provide data on HCTZ's short- and long-term effects in canine MMVD.</div></div><div><h3>Animals, materials, and methods</h3><div>Signalment, clinical, diagnostic, therapeutic, and outcome data of dogs with relapsing CHF due to MMVD treated with HCTZ were retrospectively reviewed. The initial time point was the day HCTZ was introduced for a CHF relapse. Optimized criteria were used to determine the appropriate timings for evaluating HCTZ's short-term effects on laboratory and echocardiographic variables and its long-term impact on CHF management.</div></div><div><h3>Results</h3><div>Thirty-eight dogs were included. The initial median dose of HCTZ was 0.8 mg/kg/die. At a median of seven days after HCTZ prescription, creatinine, urea, and total calcium levels significantly increased, while sodium and potassium levels significantly decreased (P: from 0.045 to <0.0001). While no dog developed severe electrolyte abnormalities, some dogs showed severe increases in creatinine and urea. After a median of 95 days, no significant echocardiographic changes developed (P: from 0.74 to 0.13). Episodes of CHF were more frequent before (median: one every 68 days) than after (median: one every 124 days) HCTZ prescription (P=0.006).</div></div><div><h3>Study limitations</h3><div>The study limitations included the retrospective design of the study; not all dogs were included both in the short- and long-term analysis.</div></div><div><h3>Conclusions</h3><div>In canine MMVD, HCTZ is useful in long-term management of relapsing CHF. However, in the short term, HCTZ can cause laboratory abnormalities, primarily increased creatinine and urea.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 57-69"},"PeriodicalIF":1.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of congestive heart failure by combining echocardiography and blood biomarkers in cats with cardiomyopathy 结合超声心动图和血液生物标志物对心肌病猫充血性心力衰竭的诊断

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-05-17 DOI: 10.1016/j.jvc.2025.05.007

T. Shimoda , T. Osuga , K. Nakamura

Introduction/Objectives

In cats with cardiomyopathy, echocardiographic indices and blood biomarkers such as atrial natriuretic peptide (ANP), cardiac troponin I (cTnI), and N-terminal pro-B-type natriuretic peptide (NTproBNP) are useful in diagnosing congestive heart failure (CHF). However, the improvement in diagnostic accuracy by combining these indicators remains unclear.

Animals, materials and methods

Twenty-six cats diagnosed with cardiomyopathy using echocardiography were included in this study. They were classified into CHF and non-CHF groups according to the presence of pulmonary oedema or pleural effusion and response to heart failure treatment. The discriminative ability of each index for the presence of CHF was evaluated using a receiver operating characteristic curve.

Results

The left atrial-to-aortic root ratio (LA/Ao) had the highest area under the curve of 0.952 (95% confidence interval [CI]: 0.878–1.0), followed by ANP 0.915 (95% CI 0: 0.808–1.0), cTnI 0.861 (95% CI: 0.722–0.999), and NTproBNP 0.830 (95% CI: 0.672–0.988). Adding NTproBNP and ANP to the LA/Ao did not improve the discriminative ability. Limited by the combination of blood biomarkers, ANP and cTnI showed the highest discriminative ability.

Study Limitations

Following were the limitations to this study: lack of standardised medication, inability to calculate true correlation for NTproBNP values >1500 pmol/L, marked difference in disease severity between groups, inclusion of various cardiomyopathy types, reliance solely on LA/Ao for left atrial size assessment, and small sample size.

Conclusions

This study indicates that if LA/Ao can be measured accurately, the significance of measuring cardiac biomarkers for diagnosing CHF in cats with cardiomyopathy is low.

在患有心肌病的猫中，超声心动图指标和血液生物标志物如心房利钠肽（ANP）、心肌肌钙蛋白I （cTnI）和n端前b型利钠肽（NTproBNP）对诊断充血性心力衰竭（CHF）很有帮助。然而，通过结合这些指标来提高诊断准确性仍不清楚。动物、材料和方法采用超声心动图诊断为心肌病的猫26只。根据是否存在肺水肿或胸腔积液以及对心力衰竭治疗的反应将患者分为CHF组和非CHF组。采用受试者工作特征曲线评价各指标对CHF存在的判别能力。结果左房主动脉根比（LA/Ao）曲线下面积最大，为0.952(95%可信区间[CI]: 0.878 ~ 1.0)，其次为ANP 0.915 （95% CI 0: 0.808 ~ 1.0）、cTnI 0.861 （95% CI: 0.722 ~ 0.999）、NTproBNP 0.830 （95% CI: 0.672 ~ 0.988）。在LA/Ao中加入NTproBNP和ANP并没有提高LA/Ao的识别能力。受血液生物标志物组合的限制，ANP和cTnI表现出最高的区分能力。以下是本研究的局限性：缺乏标准化的药物治疗，无法计算NTproBNP值>；1500 pmol/L的真实相关性，组间疾病严重程度的显着差异，包括各种心肌病类型，仅依赖LA/Ao评估左房大小，样本量小。结论本研究表明，如果能够准确测量LA/Ao，则测量心脏生物标志物对心肌病猫CHF诊断的意义较低。

{"title":"Diagnosis of congestive heart failure by combining echocardiography and blood biomarkers in cats with cardiomyopathy","authors":"T. Shimoda , T. Osuga , K. Nakamura","doi":"10.1016/j.jvc.2025.05.007","DOIUrl":"10.1016/j.jvc.2025.05.007","url":null,"abstract":"<div><h3>Introduction/Objectives</h3><div>In cats with cardiomyopathy, echocardiographic indices and blood biomarkers such as atrial natriuretic peptide (ANP), cardiac troponin I (cTnI), and N-terminal pro-B-type natriuretic peptide (NTproBNP) are useful in diagnosing congestive heart failure (CHF). However, the improvement in diagnostic accuracy by combining these indicators remains unclear.</div></div><div><h3>Animals, materials and methods</h3><div>Twenty-six cats diagnosed with cardiomyopathy using echocardiography were included in this study. They were classified into CHF and non-CHF groups according to the presence of pulmonary oedema or pleural effusion and response to heart failure treatment. The discriminative ability of each index for the presence of CHF was evaluated using a receiver operating characteristic curve.</div></div><div><h3>Results</h3><div>The left atrial-to-aortic root ratio (LA/Ao) had the highest area under the curve of 0.952 (95% confidence interval [CI]: 0.878–1.0), followed by ANP 0.915 (95% CI 0: 0.808–1.0), cTnI 0.861 (95% CI: 0.722–0.999), and NTproBNP 0.830 (95% CI: 0.672–0.988). Adding NTproBNP and ANP to the LA/Ao did not improve the discriminative ability. Limited by the combination of blood biomarkers, ANP and cTnI showed the highest discriminative ability.</div></div><div><h3>Study Limitations</h3><div>Following were the limitations to this study: lack of standardised medication, inability to calculate true correlation for NTproBNP values >1500 pmol/L, marked difference in disease severity between groups, inclusion of various cardiomyopathy types, reliance solely on LA/Ao for left atrial size assessment, and small sample size.</div></div><div><h3>Conclusions</h3><div>This study indicates that if LA/Ao can be measured accurately, the significance of measuring cardiac biomarkers for diagnosing CHF in cats with cardiomyopathy is low.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 70-78"},"PeriodicalIF":1.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divided left atrium (Cor Triatriatum Sinister) with atresia of the right pulmonary veins in a cat 猫左心房分裂伴右肺静脉闭锁

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-05-17 DOI: 10.1016/j.jvc.2025.05.008

P. Savarino , M. Borgarelli , T. Massimiliano

A nine-month-old, female Maine Coon cat was referred for acute respiratory distress. Echocardiography revealed the presence of a membrane dividing the left atrium into two chambers, suggestive of cor triatriatum sinister (CTS). Due to poor prognosis, the owner elected for humane euthanasia. At necropsy, a transverse fibromuscular membrane containing an orifice dividing the left atrium into two chambers was observed, confirming the diagnosis of CTS, or divided left atrium. Moreover, atresia of the outflow of right pulmonary veins into the left atrium was identified. This study reports the rare instance of CTS associated with anomalies of the pulmonary venous connection.

一只9个月大的雌性缅因猫因急性呼吸窘迫被转诊。超声心动图显示有一层膜将左心房分为两个腔室，提示心房三房心险恶（CTS）。由于预后不佳，主人选择了人道安乐死。尸检时，观察到一个横向纤维肌膜，其中包含一个将左心房分为两个腔室的孔，证实了CTS或分裂左心房的诊断。此外，右肺静脉流出闭锁进入左心房被确定。本研究报告罕见的CTS合并肺静脉连接异常的病例。

引用次数: 0

Ventriculophasic response in a horse with atrioventricular block 马房室传导阻滞的心室相反应

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-05-17 DOI: 10.1016/j.jvc.2025.05.005

J. Liu, R. Baumwart, S. Kwon

Ventriculophasic response (VR) in atrioventricular nodal (AVN) block is characterized by a shortening of the sinoatrial cycle length when a QRS complex is interposed between two P waves. This has been well documented in humans and dogs with AVN blocks but not in horses. Herein, we describe a horse with second-degree AVN blocks and constant PR intervals that exhibited 5:3 conduction and suspected VR at rest but less consistently after submaximal exercise. Proposed VR mechanisms include (1) inhibition of the Bezold-Jarisch reflex from reduced end-systolic volume during ventricular contraction; (2) vagal inhibition from increased intra-atrial pressure (Bainbridge reflex); and (3) accelerated sinus node discharge from changes in sinus nodal blood supply during ventricular contraction. This case exhibited some electrocardiogram characteristics of the first two mechanisms to explain the PP interval alteration and suspected VR. Horses often exhibit physiologic AVN blocks, and clinicians should consider VR when interpreting equine electrocardiograms.

房室结阻滞（AVN）的心室相反应（VR）的特征是当两个P波之间插入QRS复合体时，窦房周期长度缩短。这在人类和患有AVN阻滞的狗身上有很好的记录，但在马身上没有。本文中，我们描述了一匹具有二级AVN阻滞和恒定PR间隔的马，其在休息时表现出5:3的传导和疑似VR，但在次大运动后不那么一致。提出的VR机制包括：(1)心室收缩时收缩末期体积减少抑制Bezold-Jarisch反射；(2)心房内压力升高引起的迷走神经抑制（Bainbridge反射）；(3)心室收缩时窦结血供的改变加速了窦结放电。本病例表现出前两种机制的一些心电图特征来解释PP间期改变和疑似VR。马经常表现出生理性AVN阻滞，临床医生在解释马的心电图时应该考虑VR。

引用次数: 0

Cutting and high-pressure balloon angioplasty in a dog with concurrent pulmonary valvar and infundibular stenosis 切割术和高压球囊血管成形术治疗并发肺瓣膜和小脑狭窄1例

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Cardiology

Pub Date : 2025-05-17 DOI: 10.1016/j.jvc.2025.05.006

R.L. Winter, K.L. Maneval, C.S. Ferrel

A two-year-old, 7.7-kg female spayed Cocker spaniel dog was presented for further evaluation of severe pulmonary stenosis. Transthoracic echocardiography revealed severe concentric hypertrophy and dilation of the right ventricle, and two distinct levels of obstruction were observed. A discrete level of obstruction was observed at the crista supraventricularis. This lesion was hyperechoic and located roughly 11 mm away from the pulmonary annulus. Additionally, pulmonary leaflets were elongated and demonstrated systolic doming. These findings were consistent with concurrent pulmonary valvar and infundibular stenosis. The peak systolic pressure gradient across the pulmonary annulus assessed by continuous-wave Doppler interrogation was 190 mmHg. The following day, pulmonary balloon angioplasty was performed successfully with cutting and high-pressure balloon catheters. The day after intervention, echocardiography revealed that the peak systolic pressure gradient across the pulmonary annulus had decreased to 65 mmHg. This pressure gradient had further decreased to 30 mmHg nine months later.

一只两岁，7.7公斤的雌性绝育可卡犬被提出进一步评估严重肺狭窄。经胸超声心动图显示右心室严重的同心圆肥大和扩张，并观察到两种不同程度的梗阻。在室上嵴处观察到离散程度的梗阻。病灶高回声，位于距肺环约11mm处。此外，肺小叶拉长，显示收缩期圆顶状。这些发现与并发肺瓣膜和小脑狭窄一致。连续波多普勒测得肺环收缩压梯度峰值为190 mmHg。第二天，使用切割和高压球囊导管成功进行肺球囊血管成形术。干预后第二天，超声心动图显示肺动脉环收缩压梯度峰值降至65 mmHg。9个月后，该压力梯度进一步降至30 mmHg。

{"title":"Cutting and high-pressure balloon angioplasty in a dog with concurrent pulmonary valvar and infundibular stenosis","authors":"R.L. Winter, K.L. Maneval, C.S. Ferrel","doi":"10.1016/j.jvc.2025.05.006","DOIUrl":"10.1016/j.jvc.2025.05.006","url":null,"abstract":"<div><div>A two-year-old, 7.7-kg female spayed Cocker spaniel dog was presented for further evaluation of severe pulmonary stenosis. Transthoracic echocardiography revealed severe concentric hypertrophy and dilation of the right ventricle, and two distinct levels of obstruction were observed. A discrete level of obstruction was observed at the crista supraventricularis. This lesion was hyperechoic and located roughly 11 mm away from the pulmonary annulus. Additionally, pulmonary leaflets were elongated and demonstrated systolic doming. These findings were consistent with concurrent pulmonary valvar and infundibular stenosis. The peak systolic pressure gradient across the pulmonary annulus assessed by continuous-wave Doppler interrogation was 190 mmHg. The following day, pulmonary balloon angioplasty was performed successfully with cutting and high-pressure balloon catheters. The day after intervention, echocardiography revealed that the peak systolic pressure gradient across the pulmonary annulus had decreased to 65 mmHg. This pressure gradient had further decreased to 30 mmHg nine months later.</div></div>","PeriodicalId":48788,"journal":{"name":"Journal of Veterinary Cardiology","volume":"60 ","pages":"Pages 50-56"},"PeriodicalIF":1.5,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Journal of Veterinary Cardiology

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀