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The biochemical and metabolic adaptations underpinning the health benefits of exercise 支持运动对健康益处的生化和代谢适应
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-26 DOI: 10.1016/j.jshs.2025.101114
Robyn M. Murphy, Mark A. Febbraio
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引用次数: 0
Dose‒response associations of self-reported and device-measured physical activity with major adverse cardiovascular events in people with prevalent diseases 流行疾病患者自我报告和设备测量的体力活动与主要不良心血管事件的剂量-反应关联
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-24 DOI: 10.1016/j.jshs.2025.101116
Miguel Adriano Sanchez-Lastra, Borja del Pozo Cruz, Jakob Tarp, Knut Eirik Dalene, Tormod S. Nilsen, Ding Ding, Ulf Ekelund
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引用次数: 0
Mitigating climate change in sports leagues: A scenario-based analysis of travel distances in women’s and men’s amateur soccer in Germany 缓解体育联盟中的气候变化:基于场景的德国女子和男子业余足球旅行距离分析
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-19 DOI: 10.1016/j.jshs.2025.101112
Karim Abu-Omar, Tobias Völk, Antonina Tcymbal, Julian Resch, Dogukan Özer, Peter Gelius, Sven Messing, Heiko Ziemainz
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引用次数: 0
Exercise-induced β-hydroxybutyrate contributes to cognitive improvement in aging mice 运动诱导的β-羟基丁酸酯有助于衰老小鼠的认知改善
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-19 DOI: 10.1016/j.jshs.2025.101113
Lian Wang, Liwei Mao, Danlin Zhu, Ke Li, Haoyang Gao, Muge Zhou, Jiabin Wu, Dan Yang, Ze Wang, Wenhong Wang, Yifan Guo, Yingying Xu, Peijie Chen, Weihua Xiao
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引用次数: 0
The influence of body posture and added mass on intrinsic and extrinsic foot muscle activation and force output during common foot strengthening exercises. 在普通足部强化训练中,身体姿势和增加的质量对内在和外在足部肌肉激活和力量输出的影响。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-16 DOI: 10.1016/j.jshs.2025.101110
John W A Osborne,Hylton B Menz,Karl B Landorf,Glen A Whittaker,Matthew Cotchett,Luke A Kelly
BACKGROUNDIntrinsic and extrinsic foot muscles contribute to foot and lower limb function. This knowledge provides opportunities to target these muscles in exercise and rehabilitation. However, a barrier is the limited understanding of how prescribed exercises affect muscle activation and force output. This study examined muscle activation and torque production about the metatarsophalangeal joints of intrinsic and extrinsic foot muscles during common foot strengthening exercises. The secondary aim was to determine whether the addition of a postural change (leaning forward) or addition of mass can further increase muscle activation and torque.METHODSFifteen healthy participants (9 males, 6 females; age = 36.5 ± 8 years, mean ± SD) participated. Muscle activation was measured using fine-wire electromyography (EMG) electrodes for 2 intrinsic and 2 extrinsic muscles, and surface EMG electrodes for 4 superficial muscles. Metatarsophalangeal joint torque was measured using a custom toe dynamometer. Participants attended one 90-min session and performed 16 exercises. Five included the addition of leaning forward and 3 the addition of mass (20% of participant's mass) to compare their effects on muscle activity and torque.RESULTSMuscle activation and metatarsophalangeal joint torque varied considerably across exercises. Both the addition of leaning forward and the addition of mass increased muscle activation and metatarsophalangeal joint torque, with the addition of leaning forward producing a 35% median increase in torque about the metatarsophalangeal joints.CONCLUSIONMany common exercises, despite high muscle activation, produce relatively low metatarsophalangeal joint torque, raising questions about their clinical value. Adding a forward lean significantly increases toe flexor muscle activity and torque, reaching levels greater than added mass and comparable to walking.
背景:内源性和外源性足部肌肉有助于足部和下肢的功能。这些知识提供了在锻炼和康复中针对这些肌肉的机会。然而,一个障碍是对规定的运动如何影响肌肉激活和力量输出的理解有限。本研究考察了普通足部强化训练中足部内在和外在肌肉跖趾关节的肌肉激活和扭矩产生。第二个目的是确定增加姿势变化(前倾)或增加质量是否可以进一步增加肌肉激活和扭矩。方法健康受试者15例(男9例,女6例,年龄 = 36.5±8岁,mean±SD)。肌肉激活使用细丝肌电(EMG)电极测量2块内在肌和2块外在肌,表面肌电电极测量4块浅表肌。跖趾关节扭矩测量使用定制脚趾测力仪。参与者参加了一个90分钟的会议,并进行了16项练习。其中5项包括增加身体前倾,3项包括增加体重(参与者体重的20%),以比较它们对肌肉活动和扭矩的影响。结果:在不同的运动中,肌肉激活和跖趾关节扭矩变化很大。前倾的增加和质量的增加都增加了肌肉的激活和跖趾关节的扭矩,前倾的增加使跖趾关节的扭矩增加了35%。结论许多常用的运动虽然肌肉激活度高,但产生的跖趾关节扭矩相对较低,其临床应用价值值得怀疑。增加前倾可以显著增加脚趾屈肌的活动和扭矩,达到比增加重量更大的水平,与步行相当。
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引用次数: 0
Exercise attenuates stress-related signaling as sensed by higher phosphorylation of small heat shock proteins in skeletal muscle from older individuals. 运动减弱了老年人骨骼肌中小热休克蛋白磷酸化所感知的应激相关信号。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-16 DOI: 10.1016/j.jshs.2025.101111
Noni T Frankenberg,Victoria L Wyckelsma,Dion Ellul,Aaron C Petersen,Itamar Levinger,Michael J McKenna,Robyn M Murphy
BACKGROUNDHeat shock proteins (HSPs) are key molecular chaperones that help maintain protein homeostasis by stabilising or removing damaged proteins during cellular stress. Aging weakens these stress-response systems, disrupting proteostasis and increasing vulnerability to sarcopenia. High-intensity training (HIT) can counteract these declines by activating protective pathways such as the HSP response. HSPs are highly responsive to stress, examining their regulation during aging is important, as altered HSP activity is linked to the progressive loss of muscle mass.METHODSThis study investigated the abundance and phosphorylation of HSPs in skeletal muscle from healthy, active young and older adults (n = 7 per group), assessed at baseline and again in the older group following 12 weeks of HIT. Using calibrated Western blotting on both whole-muscle homogenates and pooled single muscle fibres, we quantified HSP content and phosphorylation to determine how aging and exercise influence stress-responsive protein regulation at both the tissue and cellular levels.RESULTSIn whole muscle homogenates, HSPs (HSP72, HSP27, and αB-crystallin) did not differ between young and older adults, while higher phosphorylation of small HSPs (sHSPs): phospho-HSP27 at Serine15 (pHSP27 Ser15) and phospho-αB-crystallin at Serine59 (pαB-crystallin Ser59) (∼1.8-fold and ∼2.9-fold, respectively) were found in muscle from older adults, indicating higher cellular stress associated with aging. A 12-week HIT intervention in older adults reduced homogenate pHSP27 Ser15 and pαB-crystallin Ser59 abundances to similar levels found in young adults. Total HSPs typically displayed a distinct fiber-type profile in both age groups, with more in type I compared to type II fibers, distinguished by the presence of myosin heavy chain I (MHCI) or MHCII. Phosphorylation at pHSP27 Ser15 and pαB-crystallin Ser59 was not different between type I and type II fibers. The HIT in older adults decreased total and phosphorylated sHSPs in both type I and type II fibers but increased HSP72 in type I fibers.CONCLUSIONHIT has the potential to mitigate age-related cellular stress and modulate protein expression patterns in aging skeletal muscle and, perhaps, has the potential to delay age-related muscle decline, thereby improving muscle health in older adults.
背景:热休克蛋白(HSPs)是关键的分子伴侣,在细胞应激过程中通过稳定或去除受损蛋白来帮助维持蛋白质稳态。衰老削弱了这些应激反应系统,破坏了蛋白质平衡,增加了肌肉减少症的易感性。高强度训练(HIT)可以通过激活保护性通路(如热休克蛋白反应)来抵消这些衰退。热休克蛋白对压力有高度的反应,在衰老过程中检查它们的调节是很重要的,因为热休克蛋白活性的改变与肌肉质量的逐渐减少有关。方法本研究调查了健康、活跃的年轻人和老年人骨骼肌中热休克蛋白的丰度和磷酸化水平(每组 = 7),在基线时进行评估,并在HIT治疗12周后对老年组进行评估。通过对全肌肉匀浆和单个肌肉纤维进行校准的Western blotting,我们量化了热休克蛋白的含量和磷酸化,以确定衰老和运动如何影响组织和细胞水平上的应激反应蛋白调节。结果在全肌肉匀浆中,热休克蛋白(HSP72、HSP27和αB-crystallin)在年轻人和老年人之间没有差异,而小热休克蛋白(sHSPs)的磷酸化水平较高:磷酸HSP27丝氨酸15位点(pHSP27 Ser15)和磷酸αB-crystallin丝氨酸59位点(pαB-crystallin Ser59)磷酸化水平分别为1.8倍和2.9倍,表明细胞应激与衰老相关。在老年人中进行为期12周的HIT干预,将匀浆pHSP27 Ser15和pαB-crystallin Ser59的丰度降低到与年轻人相似的水平。在两个年龄组中,总热休克蛋白通常显示出不同的纤维类型,与II型纤维相比,I型纤维更多,通过肌球蛋白重链I (MHCI)或MHCII的存在来区分。在I型和II型纤维中,pHSP27 Ser15和pαB-crystallin Ser59的磷酸化没有差异。老年人的HIT降低了I型和II型纤维的总sHSPs和磷酸化sHSPs,但增加了I型纤维的HSP72。结论:hit有可能减轻与年龄相关的细胞应激和调节老化骨骼肌中的蛋白质表达模式,并可能有可能延缓与年龄相关的肌肉衰退,从而改善老年人的肌肉健康。
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引用次数: 0
Exercise attenuates the hallmarks of aging: Novel perspectives. 运动减弱衰老的标志:新观点。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-04 DOI: 10.1016/j.jshs.2025.101108
Yan Qiu,Benjamin Fernández-García,H Immo Lehmann,Guoping Li,Guido Kroemer,Carlos López-Otín,Junjie Xiao
The number and proportion of individuals aged 60 years and older are steadily increasing. However, increased life expectancy is accompanied by a decline in functional capacity and a heightened risk of age-related diseases, ultimately leading to reduced quality of life. Interventions that support physiological function in later life and hence extend healthspan are therefore of considerable importance. Among these, regular physical exercise is strongly associated with numerous health benefits and is recognized as a key strategy for promoting healthy aging and extending healthspan. In this review, we highlight the impact of an active lifestyle, particularly regular physical activity, on the major hallmarks of aging. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, changes in the extracellular matrix, stem cell exhaustion, altered intercellular communication, chronic inflammation, dysbiosis, and psychosocial isolation. A deeper understanding of the mechanisms by which exercise confers these benefits will aid in enhancing both physical and mental health in the elderly and in mitigating the onset of aging-associated diseases.
60岁及以上人口的数量和比例正在稳步增长。然而,预期寿命的延长伴随着功能的下降和与年龄有关的疾病的风险增加,最终导致生活质量下降。因此,支持晚年生理功能从而延长健康寿命的干预措施是相当重要的。其中,有规律的体育锻炼与许多健康益处密切相关,被认为是促进健康老龄化和延长健康寿命的关键策略。在这篇综述中,我们强调了积极的生活方式,特别是规律的体育锻炼,对衰老的主要标志的影响。这些包括基因组不稳定、端粒磨损、表观遗传改变、蛋白质稳态丧失、巨噬受损、营养感知失调、线粒体功能障碍、细胞衰老、细胞外基质改变、干细胞衰竭、细胞间通讯改变、慢性炎症、生态失调和社会心理隔离。更深入地了解运动带来这些好处的机制将有助于增强老年人的身心健康,并减轻与衰老有关的疾病的发作。
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引用次数: 0
Does ice affect healing after muscle injury? Ask me again next century. 冰敷会影响肌肉损伤后的愈合吗?下个世纪再问我吧。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-04 DOI: 10.1016/j.jshs.2025.101107
Chris Bleakley
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引用次数: 0
Adherence to the 24-Hour Movement Guidelines is related to a lower risk of all-cause mortality: A prospective cohort study of 14,288 participants from the SUN Project. 坚持24小时运动指南可降低全因死亡率:一项来自SUN项目的14288名参与者的前瞻性队列研究。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-04 DOI: 10.1016/j.jshs.2025.101109
José Francisco López-Gil,Mark S Tremblay,Maira Bes-Rastrollo,Laura Moreno-Galarraga,Stefanos N Kales,Miguel Ángel Martínez-González,Alejandro Fernandez-Montero
OBJECTIVEThe purpose of this study is to examine the associations between adherence to the 24-Hour Movement Guidelines and all-cause and cause-specific mortality in a large Spanish prospective cohort.METHODSWe analyzed data from 14,288 participants of the Seguimiento Universidad de Navarra (SUN) Project, followed for a mean of 12.8 years (mean baseline age = 38.3 years; 60.1% women). Data were collected at baseline and through biennial follow-up questionnaires (up to 10 waves, depending on year of entry). The participants self-reported 24-h movement behaviors at baseline and were categorized based on the number of guidelines met (0-3). Behaviors were assessed at baseline only; changes in adherence during follow-up were not accounted for. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause and cause-specific mortality, adjusting for sociodemographic, lifestyle, and clinical covariates.RESULTSMeeting a greater number of 24-Hour Movement Guidelines at baseline was associated with a progressively lower risk of all-cause mortality. Compared with those meeting none, the multivariable-adjusted HRs were 0.52 (95% confidence interval (95%CI): 0.33-0.82) for meeting 1 guideline, 0.47 (95%CI: 0.30-0.73) for meeting 2 guidelines, and 0.44 (95%CI: 0.28-0.71) for meeting all 3 guidelines. Only adherence to the physical activity guidelines was independently associated with a significantly lower mortality risk (HR = 0.70; 95%CI: 0.55-0.89). A reduced risk was also observed for cancer and other-cause mortality among those meeting 2 or more guidelines.CONCLUSIONAdherence to the 24-Hour Movement Guidelines at baseline, particularly physical activity, was associated with a lower risk of mortality. Promoting an integrated approach to movement behaviors may be an effective strategy for improving population health and longevity.
目的:本研究的目的是在一项大型西班牙前瞻性队列研究中,研究坚持24小时运动指南与全因和病因特异性死亡率之间的关系。方法:我们分析了来自纳瓦拉大学(SUN)项目14288名参与者的数据,平均随访12.8年(平均基线年龄 = 38.3岁;60.1%为女性)。在基线和通过两年一次的随访问卷收集数据(多达10波,取决于入组年份)。参与者在基线时自我报告24小时运动行为,并根据满足指导方针的数量(0-3)进行分类。仅在基线时评估行为;随访期间依从性的变化未被考虑在内。Cox比例风险模型用于估计全因死亡率和特定原因死亡率的风险比(hr),并对社会人口统计学、生活方式和临床协变量进行调整。结果在基线时满足更多的24小时运动指南与逐渐降低的全因死亡风险相关。与不符合的患者相比,符合1条指南的多变量调整hr为0.52(95%可信区间(95% ci): 0.33-0.82),符合2条指南的多变量调整hr为0.47 (95% ci: 0.30-0.73),符合3条指南的多变量调整hr为0.44 (95% ci: 0.28-0.71)。仅遵守体力活动指南与显著降低的死亡风险独立相关(HR = 0.70;95%CI: 0.55-0.89)。在那些符合2项或更多指南的人群中,癌症和其他原因死亡的风险也有所降低。结论:在基线时坚持24小时运动指南,特别是体力活动,与较低的死亡风险相关。促进运动行为的综合方法可能是改善人口健康和长寿的有效策略。
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引用次数: 0
Comparative effectiveness of lifestyle interventions on children's body composition management: A systematic review and network meta-analysis. 生活方式干预对儿童身体成分管理的比较效果:系统综述和网络荟萃分析。
IF 10.3 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2025-12-01 Epub Date: 2024-11-06 DOI: 10.1016/j.jshs.2024.101008
Xiwen Su, Mohamed A Hassan, HyunJoon Kim, Zan Gao

Purpose: This study aimed to provide comparative evidence on the effectiveness of various lifestyle interventions on body composition management for preschool and school-aged children.

Methods: PubMed (MEDLINE), Embase, CINAHL, and Web of Science were systematically searched for this network meta-analysis. Randomized controlled studies (RCTs) that included children aged 4-12 years with no physical or mental conditions; performed at least 1 type of lifestyle intervention; reported change in body mass index (BMI), BMI z-score, or body fat percentage (BFP); and were published between January 2010 and August 2023 were included.

Results: The final analysis included 91 RCTs with aggregate data for 58,649 children. All interventions were categorized into single-arm approaches (physical activity, diet, and behavioral and informational support) and combined arms approaches (bicomponent and multicomponent treatment). Multicomponent treatment showed significant effectiveness on the reduction of BMI (mean deviation (MD) - 0.49, 95% confidence interval (95%CI): -0.88 to -0.12), BMI z-score (MD = -0.11, 95%CI: -0.18 to -0.04), and BFP (MD = -1.69, 95%CI: -2.97 to -0.42) compared to the usual care condition. Bicomponent treatment also significantly reduced BMI (MD = -0.28, 95%CI: -0.54 to -0.04) and BMI z-score (MD = -0.07, 95%CI: -0.12 to -0.02) compared to usual care.

Conclusion: Interventions targeting multiple lifestyle components achieved greater reductions in children's BMI and BFP. Among single-component approaches, physical activity engagement emerged as the most effective. These findings should guide practitioners in recommending comprehensive lifestyle modifications for children. Moreover, children with higher initial BMI and body fat levels tend to exhibit more positive responses to lifestyle interventions aimed at managing obesity.

目的为学龄前和学龄儿童的身体成分管理提供各种生活方式干预效果的比较证据:为进行此次网络荟萃分析,系统地检索了 PubMed (Medline)、Embase、CINAHL 和 Web of Science。纳入的随机对照研究(RCT)包括:4-12 岁无身体或精神疾病的儿童;至少实施了一种生活方式干预;报告了体重指数(BMI)、BMI z 值或体脂百分比(BFP)的变化;发表于 2010 年 1 月至 2023 年 8 月:最终分析包括 91 项 RCT,共收集了 58,649 名儿童的数据。所有干预措施分为单臂方法(体育锻炼、饮食、行为和信息支持)和组合臂方法(双组分和多组分治疗)。与常规护理相比,多组分疗法在降低体重指数(平均偏差 (MD) = 0.49,95% 置信区间 (95%CI):-0.88 至 -0.12)、体重指数 z 值(MD = -0.11,95%CI:-0.18 至 -0.04)和体重指数(BFP)(MD = -1.69,95%CI:-2.97 至 -0.42)方面有显著效果。与常规护理相比,双组分治疗还能显著降低体重指数(MD = -0.28,95%CI:-0.54 至 -0.04)和体重指数 z 值(MD = -0.07,95%CI:-0.12 至 -0.02):结论:针对多种生活方式的干预措施能更有效地降低儿童的体重指数(BMI)和体重指数(BFP)。结论:针对多种生活方式的干预措施能更有效地降低儿童的体重指数(BMI)和体重指数(BFP)。这些发现应指导从业人员为儿童推荐全面的生活方式调整。此外,初始体重指数和体脂水平较高的儿童往往会对旨在控制肥胖的生活方式干预措施表现出更积极的反应。
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Journal of Sport and Health Science
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