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Best practices for simultaneous measurement of NIRS-based cerebral and muscle oximetry during exercise. 在运动过程中同时测量基于近红外成像技术的大脑和肌肉血氧仪的最佳实践。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-10-16 DOI: 10.1016/j.jshs.2024.100997
Valentina Quaresima,Marco Ferrari,Felix Scholkmann
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引用次数: 0
Development of an accelerometer age- and sex-specific approach based on population-standardized values for physical activity surveillance: A proof of concept. 根据人口标准值开发针对不同年龄和性别的加速度计方法,用于体力活动监测:概念验证。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-10-15 DOI: 10.1016/j.jshs.2024.100995
Jairo H Migueles,Cristina Cadenas-Sanchez,Nicole M Butera,David R Bassett,Dana L Wolff-Hughes,Jennifer A Schrack,Pedro F Saint-Maurice,Eric J Shiroma
BACKGROUNDA shift from self-reports to wearable sensors for global physical activity (PA) surveillance has been recommended. The conventional use of a generic cut-point to assess moderate-to-vigorous PA (MVPA) is problematic as these cut-points are often derived from non-representative samples under non-ecological laboratory conditions. This study aimed to develop age- and sex-specific (age-sex) cut-points for MVPA based on population-standardized values as a feasible approach to assess the adherence to PA guidelines and to investigate its associations with all-cause mortality.METHODSA total of 7601 participants (20-85+ years) were drawn from the 2003-2004 and 2005-2006 National Health and Nutrition Examination Surveys (NHANES). Minutes per week of MVPA were assessed with a hip-worn accelerometer. Counts per minute (CPM) were used to define an age- and sex-specific target intensity, representing the intensity each person should be able to reach based on their age and sex. Age- and sex-specific MVPA cut-points were defined as any activity above 40% of the target intensity. These population- and free-living-based age-sex specific cut-points overcome many of the limitations of the standard generic cut-point approach. For comparison, we also calculated MVPA with a generic cut-point of 1952 CPM. Both approaches were compared for assessing adherence to PA guidelines and association of MVPA with all-cause mortality (ascertained through December 2015).RESULTSBoth approaches indicated that 37% of the sample met the 150+ min/week guideline. The generic cut-point approach showed a trend to inactivity with age, which was less pronounced using the age-sex cut-points. Overall mortality rates were comparable using generic cut-point (hazard ratio (HR) = 0.61, 95% confidence interval (95%CI): 0.50‒0.73) or age-sex cut-points (HR = 0.57, 95%CI: 0.50‒0.66) for the entire sample. The generic cut-point method revealed an age- and sex-related gap in the benefits of achieving 150+ min/week of MVPA, with older adults showing an 18% greater reduction in mortality rates than younger adults, and a larger difference in women than in men. This disparity disappeared when using age-sex-specific cut-points.CONCLUSIONOur findings underscore the value of age-sex cut-points for global PA surveillance. MVPA defined with age-sex thresholds was associated with all-cause mortality and the dose‒response was similar for all ages and sexes. This aligns with the single recommendation of accumulating 150+ min/week MVPA for all adults, irrespective of age and sex. This study serves as a proof of concept to develop this methodology for PA surveillance over more advanced open-source acceleration metrics and other national and international cohorts.
背景建议全球体力活动(PA)监测从自我报告转向可穿戴传感器。传统上使用通用切点来评估中强度体力活动(MVPA)是有问题的,因为这些切点通常是在非生态实验室条件下从非代表性样本中得出的。本研究旨在根据人群标准化值制定针对不同年龄和性别(年龄-性别)的 MVPA 切分点,以此作为一种可行的方法来评估 PA 指南的遵守情况,并研究其与全因死亡率的关系。每周进行 MVPA 的分钟数通过臀部佩戴的加速度计进行评估。每分钟计数(CPM)用于定义特定年龄和性别的目标强度,代表每个人根据其年龄和性别应达到的强度。针对不同年龄和性别的 MVPA 切点被定义为任何超过目标强度 40% 的活动。这些基于人口和自由生活的特定年龄和性别切点克服了标准通用切点方法的许多局限性。为了进行比较,我们还以 1952 CPM 的通用切点计算了 MVPA。结果两种方法都表明,37% 的样本符合 150 分钟/周以上的指导原则。通用切点法显示,随着年龄的增长,活动量呈下降趋势,而使用年龄-性别切点法时,这种趋势则不那么明显。使用通用切点法(危险比 (HR) = 0.61,95% 置信区间 (95%CI): 0.50-0.73)或年龄-性别切点法(HR = 0.57,95% 置信区间 (95%CI): 0.50-0.66)计算的整个样本的总死亡率相当。通用切点法显示,达到每周 150 分钟以上 MVPA 的益处存在年龄和性别差异,老年人的死亡率比年轻人降低 18%,女性的差异大于男性。我们的研究结果强调了年龄-性别切点在全球运动量监测中的价值。根据年龄-性别阈值定义的 MVPA 与全因死亡率相关,并且所有年龄和性别的剂量-反应相似。这与不分年龄和性别,所有成年人每周累积 150 分钟以上 MVPA 的单一建议相一致。这项研究证明了在更先进的开源加速度指标和其他国家及国际队列中开发这种方法进行运动量监测的概念。
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引用次数: 0
Comment on "Physical activity volume, intensity and life expectancy". 就 "体育活动量、强度与预期寿命 "发表评论。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-10-15 DOI: 10.1016/j.jshs.2024.100998
Barbara E Ainsworth,Zeyun Feng
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引用次数: 0
Effects of short- and long-term exercise training on cancer cells in vitro: Insights into the mechanistic associations. 短期和长期运动训练对体外癌细胞的影响:对机理关联的见解。
IF 9.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-10-05 DOI: 10.1016/j.jshs.2024.100994
Francesco Bettariga, Dennis R Taaffe, Daniel A Galvão, Robert U Newton

Exercise is a therapeutic approach in cancer treatment, providing several benefits. Moreover, exercise is associated with a reduced risk for developing a range of cancers and for their recurrence, as well as with improving survival, even though the underlying mechanisms remain unclear. Preclinical and clinical evidence shows that the acute effects of a single exercise session can suppress the growth of various cancer cell lines in vitro. This suppression is potentially due to altered concentrations of hormones (e.g., insulin) and cytokines (e.g., tumor necrosis factor alpha and interleukin 6) after exercise. These factors, known to be involved in tumorigenesis, may explain why exercise is associated with reduced cancer incidence, recurrence, and mortality. However, the effects of short- (<8 weeks) and long-term (≥8 weeks) exercise programs on cancer cells have been reported with mixed results. Although more research is needed, it appears that interventions incorporating both exercise and diet seem to have greater inhibitory effects on cancer cell growth in both apparently healthy subjects as well as in cancer patients. Although speculative, these suppressive effects on cancer cells may be driven by changes in body weight and composition as well as by a reduction in low-grade inflammation often associated with sedentary behavior, low muscle mass, and excess fat mass in cancer patients. Taken together, such interventions could alter the systemic levels of suppressive circulating factors, leading to a less favorable environment for tumorigenesis. While regular exercise and a healthy diet may establish a more cancer-suppressive environment, each acute bout of exercise provides a further "dose" of anticancer medicine. Therefore, integrating regular exercise could potentially play a significant role in cancer management, highlighting the need for future investigations in this promising area of research.

运动是治疗癌症的一种方法,具有多种益处。此外,运动还能降低罹患各种癌症及其复发的风险,并提高生存率,尽管其潜在机制仍不清楚。临床前和临床证据表明,单次运动的急性效应可抑制体外各种癌细胞株的生长。这种抑制作用可能是由于运动后激素(如胰岛素)和细胞因子(如肿瘤坏死因子α和白细胞介素6)浓度的改变。这些已知与肿瘤发生有关的因素可能解释了为什么运动与降低癌症发病率、复发率和死亡率有关。然而,运动对癌症的短期(或长期)影响并不明显。
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引用次数: 0
Effect of older age and/or ACL injury on the dose-response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein. 高龄和/或十字韧带损伤对动态负荷大小与血清软骨低聚基质蛋白即时负荷诱导变化之间剂量-反应关系的影响。
IF 9.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-10-04 DOI: 10.1016/j.jshs.2024.100993
Simon Herger, Corina Nüesch, Anna-Maria Liphardt, Christian Egloff, Annegret Mündermann

Purpose: This study aimed to assess the influence of older vs. younger age and previous anterior cruciate ligament (ACL) injury on resting serum cartilage oligomeric matrix protein (sCOMP[tpre]) concentration, on immediate load-induced sCOMP kinetics after a 30-min treadmill walking stress (∆_sCOMP[tpost]), and on the dose-response relationship between ambulatory load magnitude and ∆_sCOMP(tpost).

Methods: A total of 85 participants were recruited in 4 groups (20-30 years: 24 healthy, 23 ACL-injured; 40-60 years: 23 healthy, 15 ACL-injured). Blood samples were collected immediately before and after a walking stress at 80%, 100%, or 120% bodyweight (BW) on 3 test days and analyzed for sCOMP concentration. Linear models were used to estimate the effect of age, knee status (unilateral ACL injury, 2-10 years prior), and sex on sCOMP(tpre), ∆_sCOMP(tpost)), and the dose-response between ambulatory load magnitude and ∆_sCOMP(tpost).

Results: We found that sCOMP(tpre) was 21% higher in older than younger participants (p < 0.001) but did not differ between ACL-injured and healthy participants (p = 0.632). Also, ∆_sCOMP(tpost) was 19% lower in older than younger participants (p = 0.030) and increased with body mass index (p < 0.001), sCOMP(tpre) (p = 0.008), and with 120%BW (p < 0.001), independent of age, ACL injury, or sex.

Conclusion: Age but not prior ACL injury influences resting sCOMP and load-induced sCOMP. The dose-response relationship between ambulatory load magnitude and load-induced sCOMP changes is not affected by age, ACL injury, or sex. A better understanding of systemic sCOMP and the role of its mechanoresponse for the understanding of osteoarthritis pathophysiology and monitoring intervention efficacy may require knowledge of individual cartilage composition and tissue-level loading parameters.

目的:本研究旨在评估年龄较大与较小以及前交叉韧带(ACL)损伤对静息血清软骨寡聚基质蛋白(sCOMP(tpre))浓度、30 分钟跑步机行走应力(Δ_sCOMP(tpost))后即时负荷诱导的 sCOMP 动力学以及流动负荷大小与Δ_sCOMP(tpost)之间的剂量反应关系的影响:共招募了 85 名参与者,分为 4 组(20-30 岁:24 名健康者,23 名前交叉韧带损伤者;40-60 岁:23 名健康者,15 名前交叉韧带损伤者)。在3个测试日,分别在80%、100%或120%体重(BW)的步行压力前后采集血液样本,并分析其sCOMP浓度。我们使用线性模型估计了年龄、膝关节状况(单侧前交叉韧带损伤,2-10 年前)和性别对 sCOMP(tpre)、∆_sCOMP(tpost)的影响,以及流动负荷大小与 ∆_sCOMP(tpost) 之间的剂量反应:结果:我们发现,年龄较大的参与者的 sCOMP(tpre) 比年龄较小的参与者高 21%(p < 0.001),但前交叉韧带损伤者和健康参与者之间没有差异(p = 0.632)。此外,老年参与者的 ∆_sCOMP(tpost) 比年轻参与者低 19% (p = 0.030),并随体重指数(p < 0.001)、sCOMP(tpre) (p = 0.008)和 120%BW (p < 0.001)的增加而增加,与年龄、前交叉韧带损伤或性别无关:结论:年龄而非前交叉韧带损伤会影响静息 sCOMP 和负荷诱导 sCOMP。动态负荷大小与负荷诱导的 sCOMP 变化之间的剂量反应关系不受年龄、前交叉韧带损伤或性别的影响。要想更好地了解全身sCOMP及其机械反应的作用,以了解骨关节炎的病理生理学并监测干预效果,可能需要了解个体软骨成分和组织级负荷参数。
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引用次数: 0
GEPREP: A comprehensive data atlas of RNA-seq-based gene expression profiles of exercise responses. GEPREP:基于 RNA-seq 的运动反应基因表达谱综合数据图谱。
IF 9.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-09-26 DOI: 10.1016/j.jshs.2024.100992
Lei Sun, Jinwen Luan, Jinbiao Wang, Xiaoli Li, Wenqian Zhang, Xiaohui Ji, Longhua Liu, Ru Wang, Bingxiang Xu

Background: Physical activity can regulate and affect gene expression in multiple tissues and cells. Recently, with the development of next-generation sequencing, a large number of RNA-sequencing (RNA-seq)-based gene expression profiles about physical activity have been shared in public resources; however, they are poorly curated and underutilized. To tackle this problem, we developed a data atlas of such data through comprehensive data collection, curation, and organization.

Methods: The data atlas, termed gene expression profiles of RNA-seq-based exercise responses (GEPREP), was built on a comprehensive collection of high-quality RNA-seq data on exercise responses. The metadata of each sample were manually curated. Data were uniformly processed and batch effects corrected. All the information was well organized in an easy-to-use website for free search, visualization, and download.

Results: GEPREP now includes 69 RNA-seq datasets of pre- and post-exercise, comprising 26 human datasets (1120 samples) and 43 mouse datasets (1006 samples). Specifically, there were 977 (87.2 %) human samples of skeletal muscle and 143 (12.8 %) human samples of blood. There were also samples across 9 mice tissues with skeletal muscle (359, 35.7 %) and brain (280, 27.8 %) accounting for the main fractions. Metadata-including subject, exercise interventions, sampling sites, and post-processing methods-are also included. The metadata and gene expression profiles are freely accessible at http://www.geprep.org.cn/.

Conclusion: GEPREP is a comprehensive data atlas of RNA-seq-based gene expression profiles responding to exercise. With its reliable annotations and user-friendly interfaces, it has the potential to deepen our understanding of exercise physiology.

背景:体育锻炼可以调节和影响多种组织和细胞的基因表达。最近,随着新一代测序技术的发展,大量基于 RNA 序列(RNA-seq)的体育锻炼基因表达图谱已在公共资源中得到共享;然而,这些图谱的整理和利用率很低。为了解决这个问题,我们通过全面的数据收集、整理和组织,开发了此类数据的数据图集:该数据图谱被称为基于 RNA-seq 的运动反应基因表达谱(GEPREP),它建立在对高质量运动反应 RNA-seq 数据的全面收集之上。每个样本的元数据都经过人工编辑。数据经过统一处理和批次效应校正。所有信息都被精心组织在一个易于使用的网站上,供免费搜索、可视化和下载:GEPREP目前包括69个运动前后的RNA-seq数据集,其中有26个人类数据集(1120个样本)和43个小鼠数据集(1006个样本)。具体来说,有 977 份(87.2%)人类骨骼肌样本和 143 份(12.8%)人类血液样本。此外,还有 9 种小鼠组织的样本,其中骨骼肌(359 个,占 35.7%)和大脑(280 个,占 27.8%)是主要部分。元数据(包括受试者、运动干预、采样地点和后处理方法)也包括在内。元数据和基因表达谱可在 http://www.geprep.org.cn/.Conclusion 免费访问:GEPREP 是基于 RNA-seq 的基因表达图谱的运动反应综合数据图集。它具有可靠的注释和友好的用户界面,有望加深我们对运动生理学的理解。
{"title":"GEPREP: A comprehensive data atlas of RNA-seq-based gene expression profiles of exercise responses.","authors":"Lei Sun, Jinwen Luan, Jinbiao Wang, Xiaoli Li, Wenqian Zhang, Xiaohui Ji, Longhua Liu, Ru Wang, Bingxiang Xu","doi":"10.1016/j.jshs.2024.100992","DOIUrl":"10.1016/j.jshs.2024.100992","url":null,"abstract":"<p><strong>Background: </strong>Physical activity can regulate and affect gene expression in multiple tissues and cells. Recently, with the development of next-generation sequencing, a large number of RNA-sequencing (RNA-seq)-based gene expression profiles about physical activity have been shared in public resources; however, they are poorly curated and underutilized. To tackle this problem, we developed a data atlas of such data through comprehensive data collection, curation, and organization.</p><p><strong>Methods: </strong>The data atlas, termed gene expression profiles of RNA-seq-based exercise responses (GEPREP), was built on a comprehensive collection of high-quality RNA-seq data on exercise responses. The metadata of each sample were manually curated. Data were uniformly processed and batch effects corrected. All the information was well organized in an easy-to-use website for free search, visualization, and download.</p><p><strong>Results: </strong>GEPREP now includes 69 RNA-seq datasets of pre- and post-exercise, comprising 26 human datasets (1120 samples) and 43 mouse datasets (1006 samples). Specifically, there were 977 (87.2 %) human samples of skeletal muscle and 143 (12.8 %) human samples of blood. There were also samples across 9 mice tissues with skeletal muscle (359, 35.7 %) and brain (280, 27.8 %) accounting for the main fractions. Metadata-including subject, exercise interventions, sampling sites, and post-processing methods-are also included. The metadata and gene expression profiles are freely accessible at http://www.geprep.org.cn/.</p><p><strong>Conclusion: </strong>GEPREP is a comprehensive data atlas of RNA-seq-based gene expression profiles responding to exercise. With its reliable annotations and user-friendly interfaces, it has the potential to deepen our understanding of exercise physiology.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"100992"},"PeriodicalIF":9.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice. 运动诱导分泌蛋白 Decorin 与乳腺癌患者预后的改善有关,但在小鼠体内并不介导抗肿瘤组织串联。
IF 9.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-09-26 DOI: 10.1016/j.jshs.2024.100991
Marit Hjorth, Casey L Egan, Guilherme D Telles, Martin Pal, David Gallego-Ortega, Oliver K Fuller, Emma D McLennan, Ryan D Gillis, Tae Gyu Oh, George E O Muscat, Surafel Tegegne, Michael Sm Mah, Joanna Skhinas, Emma Estevez, Timothy E Adams, Matthew J McKay, Mark Molloy, Kevin I Watt, Hongwei Qian, Paul Gregorevic, Thomas R Cox, Pernille Hojman, Julie Midtgaard, Jesper F Christensen, Martin Friedrichsen, Renato V Iozzo, Erica K Sloan, Brian G Drew, Jørgen F P Wojtaszewski, Martin Whitham, Mark A Febbraio

Background: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood.

Methods: We used a variety of rodent and human experimental model systems to determine whether exercise training can reduce tumor burden in breast cancer and to identify mechanism associated with any exercise training effects on tumor burden.

Results: We show that voluntary wheel running slows tumor development in the mammary specific polyomavirus middle T antigen overexpression (MMTV-PyMT) mouse model of breast cancer but only when mice are not housed alone. We identify the proteoglycan decorin as a contraction-induced secretory factor that systemically increases in patients with breast cancer immediately following exercise. Moreover, high expression of decorin in tumors is associated with improved prognosis in patients, while treatment of breast cancer cells in vitro with decorin reduces cell proliferation. Notwithstanding, when we overexpressed decorin in murine muscle or injected recombinant decorin systemically into mouse models of breast cancer, elevated plasma decorin concentrations did not result in higher tumor decorin levels and tumor burden was not improved.

Conclusion: Exercise training is anti-tumorigenic in a mouse model of luminal breast cancer, but the effect is abrogated by social isolation. The proteoglycan decorin is an exercise-induced secretory protein, and tumor decorin levels are positively associated with improved prognosis in patients. The hypothesis that elevated plasma decorin is a mechanism by which exercise training improves breast cancer progression in humans is not, however, supported by our pre-clinical data since elevated circulating decorin did not increase tumor decorin levels in these models.

背景:经常锻炼可以降低乳腺癌的发病率和恶化程度,但其作用机制尚不完全清楚:有规律的运动可以降低乳腺癌的发病率和进展,但这种作用的机制还不完全清楚:方法:我们使用多种啮齿动物和人类实验模型系统来确定运动训练是否能减轻乳腺癌的肿瘤负荷,并找出运动训练对肿瘤负荷产生影响的相关机制:结果:我们发现,在乳腺特异性多瘤病毒中间T抗原过表达(MMTV-PyMT)乳腺癌小鼠模型中,自主轮跑能减缓肿瘤的发展,但只有当小鼠不单独饲养时才会出现这种情况。我们发现蛋白多糖缀合素是一种收缩诱导的分泌因子,乳腺癌患者在运动后体内缀合素会立即增加。此外,肿瘤中多黏蛋白的高表达与患者预后的改善有关,而用多黏蛋白处理体外乳腺癌细胞可减少细胞增殖。尽管如此,当我们在小鼠肌肉中过表达去甲斑蝥素或在乳腺癌小鼠模型中全身注射重组去甲斑蝥素时,血浆中去甲斑蝥素浓度的升高并不会导致肿瘤中去甲斑蝥素水平的升高,肿瘤负荷也不会得到改善:结论:在腔隙性乳腺癌小鼠模型中,运动训练具有抗肿瘤作用,但这种作用会因社会隔离而减弱。蛋白多糖缀合素是一种运动诱导分泌蛋白,肿瘤缀合素水平与患者预后的改善呈正相关。然而,我们的临床前数据并不支持血浆缀合素升高是运动训练改善人类乳腺癌进展的机制这一假设,因为在这些模型中,循环中缀合素的升高并没有增加肿瘤缀合素的水平。
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引用次数: 0
Commentary on "The association of diet quality and physical activity with cardiovascular disease and mortality in 85,545 alder Australians: A longitudinal study". 关于 "85,545 名桤木澳大利亚人的饮食质量和体力活动与心血管疾病和死亡率的关系:纵向研究"。
IF 9.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-09-21 DOI: 10.1016/j.jshs.2024.100990
Barbara E Ainsworth, Zeyun Feng
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引用次数: 0
Lower limb coordination patterns following anterior cruciate ligament reconstruction:A longitudinal study: Longitudinal lower limb coordination patterns following ACLR. 前交叉韧带重建术后的下肢协调模式:纵向研究:前交叉韧带重建术后下肢协调模式的纵向研究。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-09-17 DOI: 10.1016/j.jshs.2024.100988
Cortney Armitano-Lago,Elizabeth Bjornsen,Caroline Lisee,Ashley Buck,Christin Büttner,Adam W Kiefer,Todd A Schwartz,Brian Pietrosimone
BACKGROUNDChanges in lower limb joint coordination have been shown to increase localized stress on knee joint soft tissue-a known precursor of osteoarthritis. While 50% of individuals who undergo anterior cruciate ligament reconstruction (ACLR) develop radiographic osteoarthritis, it is unclear how underlying joint coordination during gait changes post-ACLR. The purpose of this study was twofold: to determine differences in lower limb coordination patterns during gait in ACLR individuals 2, 4, and 6 months post-ACLR and to compare the coordination profiles of the ACLR participants at each timepoint post-ACLR to uninjured matched controls.METHODSWe conducted a longitudinal assessment to quantify lower limb coordination at 3 timepoints post-ACLR and compared the ACLR coordination profiles to uninjured controls. Thirty-four ACLR (age = 21.43 ± 4.24 years, mean ± SD; 70.59% female) and 34 controls (age = 21.42 ± 3.43 years; 70.59% female) participated. The ACLR group completed 3 overground gait assessments (2,4, and 6 months post-ACLR), and the controls completed 1 assessment, at which lower limb kinematics were collected. Cross-recurrence quantification analysis was used to characterize sagittal and frontal plane ankle-knee, ankle-hip, and knee-hip coordination dynamics. Comprehensive general linear mixed models were constructed to compare between-limb and within-limb coordination outcomes over time post-ACLR and a between-group comparison across timepoints.RESULTSThe ACLR limb demonstrated a more "stuck" sagittal plane knee-hip coordination profile (greater trapping time (TT); p = 0.004) compared bilaterally. Between groups, the ACLR participants exhibited a more predictable ankle-knee coordination pattern (percent determinism (%DET); p < 0.05), stronger coupling between joints (meanline (MNLine)) across all segments (p < 0.05), and greater knee-hip TT (more "stuck"; p < 0.05) compared to the controls at each timepoint in the sagittal plane. Stronger frontal plane knee-hip joint coupling (MNLine) persisted across timepoints within the ACLR group compared to the controls (p < 0.05).CONCLUSIONThe results indicate ACLR individuals exhibit a distinct and rigid coordination pattern during gait compared to controls within 6-month post-ACLR, which may have long-term implications for knee-joint health.
背景下肢关节协调性的变化已被证明会增加膝关节软组织的局部应力--这是已知的骨关节炎的前兆。接受前交叉韧带重建术(ACLR)的人中有 50%会发展成放射性骨关节炎,但目前还不清楚 ACLR 术后步态过程中潜在的关节协调性是如何变化的。本研究的目的有二:确定 ACLR 术后 2、4 和 6 个月时 ACLR 患者步态过程中下肢协调模式的差异,并将 ACLR 术后每个时间点的 ACLR 参与者的协调情况与未受伤的匹配对照组进行比较。34 名 ACLR(年龄 = 21.43 ± 4.24 岁,平均 ± SD;70.59% 为女性)和 34 名对照组(年龄 = 21.42 ± 3.43 岁;70.59% 为女性)参加了评估。ACLR 组完成了 3 次地面步态评估(ACLR 术后 2、4 和 6 个月),对照组完成了 1 次评估,并收集了下肢运动学数据。交叉复现量化分析用于描述矢状面和额面的踝-膝、踝-髋和膝-髋协调动态。结果:与双侧相比,前交叉韧带损伤肢体的矢状面膝髋关节协调状况更 "卡"(更长的困顿时间 (TT);P = 0.004)。在各组之间,与对照组相比,前交叉韧带重建肢体在矢状面的每个时间点都表现出更可预测的踝-膝协调模式(确定性百分比 (%DET);p < 0.05)、更强的所有节段关节间耦合(平均线 (MNLine))(p < 0.05)和更大的膝-髋 TT(更 "卡";p < 0.05)。结果表明,与对照组相比,前交叉韧带损伤后 6 个月内的前交叉韧带损伤患者在步态过程中表现出独特而僵硬的协调模式,这可能会对膝关节健康产生长期影响。
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引用次数: 0
Are changes in pain intensity related to changes in balance control in individuals with chronic non-specific low back pain? A systematic review and meta-analysis. 疼痛强度的变化与慢性非特异性腰背痛患者平衡控制能力的变化有关吗?系统回顾和荟萃分析。
IF 11.7 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM Pub Date : 2024-09-16 DOI: 10.1016/j.jshs.2024.100989
Daniel K Y Zheng,Jae Q J Liu,Jeremy R Chang,Jeffrey C Y Ng,Zhixing Zhou,Jinlong Wu,Chelsia K C Cheung,Frank F Huang,Sabina M Pinto,Dino Samartzis,Manuela L Ferreira,Kanchana Ekanayake,Stephen Lord,Xueqiang Wang,Arnold Y L Wong
PURPOSEThe aim of this study is to summarize the evidence regarding whether pain reduction in individuals with chronic non-specific low back pain (CNSLBP) following conservative interventions is related to corresponding improvements in balance control.METHODSRandomized controlled trials were identified from 5 databases (MEDLINE, Cochrane Library, Embase, Web of Science, and PsycINFO). Two reviewers independently screened and identified relevant studies that investigated the effects of nonsurgical or nonpharmacological CNSLBP treatments on both pain intensity and balance control. Meta-regression analyses were performed to establish the associations between post-treatment changes in these 2 variables.RESULTS31 studies involving 1280 participants with CNSLBP were included. Moderate-quality evidence suggested that pain reduction was associated with and explained 34%-45% of decreases in body sway, as measured by center-of-pressure (CoP) area and CoP velocity with eyes open. However, no significant association was observed between pain reduction and CoP area or velocity in anteroposterior/mediolateral directions. Similarly, there was no significant association between pain reduction and CoP distance or radius. Low-quality evidence indicated that pain relief explained a 15% improvement in one-leg stance with eyes open but not in the eyes-closed condition. Additionally, very low-quality evidence suggested that pain relief explained a 44% decrease in the static anteroposterior stability index with eyes closed but not in the eyes-open, mediolateral, or overall conditions. Furthermore, low-quality evidence indicated that reduced pain was associated with and accounted for 25%-43% of the improved composite and posteromedial scores of the star-excursion balance test, rather than the anterior and posterolateral scores.CONCLUSIONDepending on the type of balance assessment, pain relief following conservative interventions may slightly to moderately enhance balance control in individuals with CNSLBP. Clinicians should pay close attention to the balance control in patients with CNSLBP, particularly among older adults.
目的本研究旨在总结有关慢性非特异性腰背痛(CNSLBP)患者在接受保守干预后疼痛减轻是否与平衡控制能力的相应改善有关的证据。方法从 5 个数据库(MEDLINE、Cochrane Library、Embase、Web of Science 和 PsycINFO)中确定了随机对照试验。两名审稿人独立筛选并确定了相关研究,这些研究调查了非手术或非药物 CNSLBP 治疗对疼痛强度和平衡控制的影响。结果共纳入 31 项研究,涉及 1280 名 CNSLBP 患者。中等质量的证据表明,疼痛的减轻与身体摇摆的减少有关,并解释了身体摇摆减少的 34%-45% 的原因,身体摇摆是通过压力中心 (CoP) 面积和睁眼时的 CoP 速度测量的。然而,在疼痛减轻与前胸/中外侧方向的 CoP 面积或速度之间没有观察到明显的关联。同样,疼痛减轻与CoP距离或半径之间也无明显关联。低质量的证据表明,疼痛缓解可以解释睁眼时单腿站立15%的改善,而闭眼时则无法解释。此外,极低质量的证据表明,疼痛缓解可以解释闭眼状态下静态前后稳定性指数下降 44% 的原因,但在睁眼、内外侧或整体状态下则无法解释。此外,低质量证据表明,疼痛减轻与星形外展平衡测试的综合评分和后内侧评分的提高有关,占 25%-43% 的比例,而不是前侧和后外侧评分的提高。结论根据平衡评估的类型,保守干预后疼痛减轻可能会轻微至适度增强 CNSLBP 患者的平衡控制能力。临床医生应密切关注 CNSLBP 患者的平衡控制能力,尤其是老年人。
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Journal of Sport and Health Science
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