Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240756
Di Yu, Youyou Li, Fanlei Kong, Wenpei Xie
Methylglyoxal was produced by the degradation of glucose, and its role in producing 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) was studied attempting to clarify the reaction pathways. The study showed that the PhIP yield was decreased when glucose was added to a mixture of phenylacetaldehyde and creatinine or when methylglyoxal was incorporated into a blend of phenylalanine (phenylacetaldehyde), creatinine and glucose in proportions of 1:1:0.5. PhIP yield was firstly increased and then decreased when glucose was incorporated into a blend of phenylalanine and creatinine. When methylglyoxal was added to the creatinine/phenylacetaldehyde/glucose mixture, methylglyoxal achieved around 83.2% inhibition of PhIP. However methylglyoxal achieved around 39% inhibition of PhIP in the creatinine/phenylalanine/glucose mixture. All of these results indicate that the addition of methylglyoxal to the phenylacetaldehyde/creatinine mixture inhibited the formation of PhIP. A pathway which the inhibitory effect of methylglyoxal on PhIP composition is proposed. Meanwhile, this study explained the ways in which glucose are involved in the composition of PhIP, and helped us better study the formation mechanism of PhIP.
{"title":"Inhibitory effects of methylglyoxal (MGO) on the formation of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) in model system","authors":"Di Yu, Youyou Li, Fanlei Kong, Wenpei Xie","doi":"10.54254/2753-8818/29/20240756","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240756","url":null,"abstract":"Methylglyoxal was produced by the degradation of glucose, and its role in producing 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) was studied attempting to clarify the reaction pathways. The study showed that the PhIP yield was decreased when glucose was added to a mixture of phenylacetaldehyde and creatinine or when methylglyoxal was incorporated into a blend of phenylalanine (phenylacetaldehyde), creatinine and glucose in proportions of 1:1:0.5. PhIP yield was firstly increased and then decreased when glucose was incorporated into a blend of phenylalanine and creatinine. When methylglyoxal was added to the creatinine/phenylacetaldehyde/glucose mixture, methylglyoxal achieved around 83.2% inhibition of PhIP. However methylglyoxal achieved around 39% inhibition of PhIP in the creatinine/phenylalanine/glucose mixture. All of these results indicate that the addition of methylglyoxal to the phenylacetaldehyde/creatinine mixture inhibited the formation of PhIP. A pathway which the inhibitory effect of methylglyoxal on PhIP composition is proposed. Meanwhile, this study explained the ways in which glucose are involved in the composition of PhIP, and helped us better study the formation mechanism of PhIP.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"68 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240615
Xusheng Zhang
Antibodies are immunoglobulins produced in vivo by immune cells stimulated by exogenous molecules, and nano-antibodies are a class of molecules that are similar to conventional antibodies but smaller in size. Originally discovered as an antibody in camelidsand cartilaginous fishes, they are called heavy chain antibodies due to the lack of light and heavy chain constant regions in the CH1 region except for the retained heavy chain, and their binding region to the antigen consists of the heavy chain variable region only, making them the smallest antibodies available with complete antibody functional properties. In this experiment, we analyzed the commonalities and differences of the nanobodies by extracting all their amino acid sequences, performed protein modeling of the relevant nanobodies of coronaviruses among them, and then analyzed the data of RMSD and RMSF by using molecular dynamics simulation, and finally predicted and analyzed the protein conformation and the structures of VHH at all levels.
{"title":"Sequence and structure statistics of the nanobody database and molecular dynamics simulation analysis of the nanobody VHH","authors":"Xusheng Zhang","doi":"10.54254/2753-8818/29/20240615","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240615","url":null,"abstract":"Antibodies are immunoglobulins produced in vivo by immune cells stimulated by exogenous molecules, and nano-antibodies are a class of molecules that are similar to conventional antibodies but smaller in size. Originally discovered as an antibody in camelidsand cartilaginous fishes, they are called heavy chain antibodies due to the lack of light and heavy chain constant regions in the CH1 region except for the retained heavy chain, and their binding region to the antigen consists of the heavy chain variable region only, making them the smallest antibodies available with complete antibody functional properties. In this experiment, we analyzed the commonalities and differences of the nanobodies by extracting all their amino acid sequences, performed protein modeling of the relevant nanobodies of coronaviruses among them, and then analyzed the data of RMSD and RMSF by using molecular dynamics simulation, and finally predicted and analyzed the protein conformation and the structures of VHH at all levels.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"63 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240791
Jingyu Chen
Due to the multiple cancer variants in the world, the treatment of cancer around the world has gradually fallen into a bottleneck. This article takes breast cancer as the prototype, describes in detail the causes of breast cancer, the treatment plan and the dilemma faced by the treatment of breast cancer, and puts forward a new idea for conquering breast cancer, as well as the prospect and expectation for the future human fight against cancer.
{"title":"Insight into breast cancer mechanism, drug resistance and treatment methods","authors":"Jingyu Chen","doi":"10.54254/2753-8818/29/20240791","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240791","url":null,"abstract":"Due to the multiple cancer variants in the world, the treatment of cancer around the world has gradually fallen into a bottleneck. This article takes breast cancer as the prototype, describes in detail the causes of breast cancer, the treatment plan and the dilemma faced by the treatment of breast cancer, and puts forward a new idea for conquering breast cancer, as well as the prospect and expectation for the future human fight against cancer.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"94 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240777
Menghan Li
Nowadays, more and more studies indicate that heat exposure negatively affects human health. As climate change and global warming increased, extreme heat exposure became more rigorous and killed mountains of people every year. Extreme heat is not only a threat to physical health but also to mental health. Epidemiological studies have shown that heat waves can increase peoples morbidity and mortality. This literature review will discuss in detail the impact of extreme heat on human health, and what measures governments and individuals can take to respond to or prevent the damage of extreme heat. We used extreme heat and human health as keywords to collect the papers in the Embase database and review all the results. After sorting out all the results, the research focuses on the effect of extreme heat exposure on human physical and mental health. It can be found that extreme heat exposure causes heat-related illnesses (HRI) and aggravates chronic diseases, especially cardiovascular and respiratory diseases. And extreme heat can also lead to Preterm birth (PTB) which threatens the lives of pregnant women and infants. Mental health and related deaths are also affected by extreme heat exposure.
{"title":"Research on the effects of extreme heat exposure on human health","authors":"Menghan Li","doi":"10.54254/2753-8818/29/20240777","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240777","url":null,"abstract":"Nowadays, more and more studies indicate that heat exposure negatively affects human health. As climate change and global warming increased, extreme heat exposure became more rigorous and killed mountains of people every year. Extreme heat is not only a threat to physical health but also to mental health. Epidemiological studies have shown that heat waves can increase peoples morbidity and mortality. This literature review will discuss in detail the impact of extreme heat on human health, and what measures governments and individuals can take to respond to or prevent the damage of extreme heat. We used extreme heat and human health as keywords to collect the papers in the Embase database and review all the results. After sorting out all the results, the research focuses on the effect of extreme heat exposure on human physical and mental health. It can be found that extreme heat exposure causes heat-related illnesses (HRI) and aggravates chronic diseases, especially cardiovascular and respiratory diseases. And extreme heat can also lead to Preterm birth (PTB) which threatens the lives of pregnant women and infants. Mental health and related deaths are also affected by extreme heat exposure.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"78 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240760
Yuxiao Lin
This review presents an overview of vagus nerve stimulation (VNS) utilization. The vagus nerve (VN) is among the most versatile and important nerves, with the capability to regulate a few bodily functions, and has been playing a vital role as part of therapies for a range of health concerns. VNS is an effective therapeutic method, which has gotten the approval of the Food and Drug Administration (FDA) of the United States. It is a type of neurostimulation method that plays a crucial part in drug-resistant depression and refractory epilepsy. It provides a surgical option for patients suffering from the conditions mentioned above, and is rather effective compared with other surgical approaches, thus improving patients life quality. Despite side effects, it is considered a decent therapeutic method and is currently used widely clinically. Furthermore, the mechanisms of VNS have not been completely understood. Therefore, further research is necessary, to discover the potential of VNS as an additional therapy for various other medical conditions.
{"title":"Vagus nerve stimulation on epilepsy and depression","authors":"Yuxiao Lin","doi":"10.54254/2753-8818/29/20240760","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240760","url":null,"abstract":"This review presents an overview of vagus nerve stimulation (VNS) utilization. The vagus nerve (VN) is among the most versatile and important nerves, with the capability to regulate a few bodily functions, and has been playing a vital role as part of therapies for a range of health concerns. VNS is an effective therapeutic method, which has gotten the approval of the Food and Drug Administration (FDA) of the United States. It is a type of neurostimulation method that plays a crucial part in drug-resistant depression and refractory epilepsy. It provides a surgical option for patients suffering from the conditions mentioned above, and is rather effective compared with other surgical approaches, thus improving patients life quality. Despite side effects, it is considered a decent therapeutic method and is currently used widely clinically. Furthermore, the mechanisms of VNS have not been completely understood. Therefore, further research is necessary, to discover the potential of VNS as an additional therapy for various other medical conditions.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"62 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240643
Letao Lu, Sishuo Ye
In the US, hepatocellular carcinoma (HCC), which accounts for 75%85% of instances of liver cancer, is a substantial cause of cancer-related fatalities. This review focuses on the recent developments in managing HCC, specifically through Trans-arterial Chemoembolization (TACE), which is currently first-line recommended and boasts a high survival rate. We have also discussed gene therapy, which aims to correct or replace faulty genes contributing to HCC development. Although it is still on trial, early results show promise. There are also various treatments such as OLT, molecularly targeted therapy, radiation therapy, locoregional therapies, gene therapy and immunotherapy. We have also come up with an innovative idea of creating a therapeutic vaccine using circRNA instead of mRNA, along with LNP, to treat HCC. This approach combines the benefits and functions of both circRNA and LNP. Different components of LNP aid in diverse benefits, to name but a few, stability, encapsulation and delivery efficiency, and higher targeting specificity. The use of circRNA offers adjuvant to immune response and better stability. Recent studies suggest that this hypothesis is theoretically possible. A better understanding of the hazardous disease could lead to the development of more effective treatments, which are urgently needed.
{"title":"Recent treatments to Hepatocellular Carcinoma Cancer(HCC): update and outlook","authors":"Letao Lu, Sishuo Ye","doi":"10.54254/2753-8818/29/20240643","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240643","url":null,"abstract":"In the US, hepatocellular carcinoma (HCC), which accounts for 75%85% of instances of liver cancer, is a substantial cause of cancer-related fatalities. This review focuses on the recent developments in managing HCC, specifically through Trans-arterial Chemoembolization (TACE), which is currently first-line recommended and boasts a high survival rate. We have also discussed gene therapy, which aims to correct or replace faulty genes contributing to HCC development. Although it is still on trial, early results show promise. There are also various treatments such as OLT, molecularly targeted therapy, radiation therapy, locoregional therapies, gene therapy and immunotherapy. We have also come up with an innovative idea of creating a therapeutic vaccine using circRNA instead of mRNA, along with LNP, to treat HCC. This approach combines the benefits and functions of both circRNA and LNP. Different components of LNP aid in diverse benefits, to name but a few, stability, encapsulation and delivery efficiency, and higher targeting specificity. The use of circRNA offers adjuvant to immune response and better stability. Recent studies suggest that this hypothesis is theoretically possible. A better understanding of the hazardous disease could lead to the development of more effective treatments, which are urgently needed.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"59 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240772
Yinzhi Shen
The exposure of the human body to different chemical substances poses a critical hazard to public well-being. Chemical toxicity is fundamentally ascribed to the disturbance of typical biological processes and can result in unfavorable health results. Understanding the components by which chemical substances apply their harmful impacts is vital for surveying and moderating these dangers. In this research, it will discuss the different routes of exposure, such as inhalation ingestion and dermal contact through which chemicals can enter the body. This research investigates the complex instruments at the atomic and cellular levels, counting oxidative stretch DNA harm and disturbance of enzymatic pathways by which harmful impacts are actuated. The evaluation of chemical toxicity includes a range of toxicological considerations, including acute and chronic toxicity tests, genotoxicity measures, and carcinogenicity evaluations. The development of reliable toxicity evaluation strategies, such as in vitro and in silico models, plays an urgent part in predicting the adverse impacts of chemical substances. Administrative systems and hazard evaluation techniques are discussed to guarantee peoples and the environments security. A comprehensive understanding of the components and assessment of poisonous side impacts is essential for defending open health and minimizing the hindering effects of chemical exposure.
人体接触不同的化学物质会对公众健康造成严重危害。化学毒性从根本上说是由于典型的生物过程受到干扰，并可能导致不利的健康结果。了解化学物质产生有害影响的成分对于调查和减缓这些危险至关重要。本研究将讨论化学品进入人体的不同接触途径，如吸入、摄入和皮肤接触。这项研究将调查原子和细胞层面的复杂仪器，计算氧化伸展 DNA 的伤害和酶途径的干扰，通过这些途径产生有害影响。化学毒性评估包括一系列毒理学考虑因素，包括急性和慢性毒性试验、遗传毒性测量和致癌性评估。开发可靠的毒性评估策略，如体外和硅学模型，在预测化学物质的不利影响方面发挥着迫切的作用。讨论了管理制度和危害评估技术，以确保人类和环境的安全。全面了解毒副作用的成分和评估对于保护公众健康和最大限度地减少化学品暴露的有害影响至关重要。
{"title":"Mechanism analysis of toxic and side effects of chemicals on human body","authors":"Yinzhi Shen","doi":"10.54254/2753-8818/29/20240772","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240772","url":null,"abstract":"The exposure of the human body to different chemical substances poses a critical hazard to public well-being. Chemical toxicity is fundamentally ascribed to the disturbance of typical biological processes and can result in unfavorable health results. Understanding the components by which chemical substances apply their harmful impacts is vital for surveying and moderating these dangers. In this research, it will discuss the different routes of exposure, such as inhalation ingestion and dermal contact through which chemicals can enter the body. This research investigates the complex instruments at the atomic and cellular levels, counting oxidative stretch DNA harm and disturbance of enzymatic pathways by which harmful impacts are actuated. The evaluation of chemical toxicity includes a range of toxicological considerations, including acute and chronic toxicity tests, genotoxicity measures, and carcinogenicity evaluations. The development of reliable toxicity evaluation strategies, such as in vitro and in silico models, plays an urgent part in predicting the adverse impacts of chemical substances. Administrative systems and hazard evaluation techniques are discussed to guarantee peoples and the environments security. A comprehensive understanding of the components and assessment of poisonous side impacts is essential for defending open health and minimizing the hindering effects of chemical exposure.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"59 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240770
Anqi Lin
Circadian rhythms are the innate approximately 24-hour oscillations that orchestrate a multitude of physiological processes encompassing sleep-wake cycles, hormone secretion, thermoregulation, metabolism, and behavioral patterns. Also, those rhythms are intrinsically governed by the suprachiasmatic nucleus (SCN) ensconced in the anterior hypothalamic region. The SCN, synchronized during daylight hours receives and transmits diverse bodily signals to calibrate physiological dynamics, and imbue disturbances with potential repercussions reverberating across a plethora of physiological and behavioral domains. Previous studies have proven that the diurnal changes in the circadian rhythm multiple myocardial processes and have a critical impact on the physiology and pathophysiology of the cardiovascular system. This comprehensive review emphasizes the profound influence of circadian rhythms, orchestrated by the suprachiasmatic nucleus, on cardiovascular health. It reveals that disruptions in circadian rhythms impact blood pressure, myocardial function, platelet responsiveness, and the autonomic nervous system, all of which are critical for cardiovascular well-being. The significance of this research lies in its potential to guide interventions for cardiovascular disease prevention and management, particularly in the context of modern challenges like shift work. Understanding this intricate relationship is crucial for safeguarding cardiovascular health in our fast-paced world.
{"title":"Impact of the circadian clock on cardiovascular physiology and pathophysiology","authors":"Anqi Lin","doi":"10.54254/2753-8818/29/20240770","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240770","url":null,"abstract":"Circadian rhythms are the innate approximately 24-hour oscillations that orchestrate a multitude of physiological processes encompassing sleep-wake cycles, hormone secretion, thermoregulation, metabolism, and behavioral patterns. Also, those rhythms are intrinsically governed by the suprachiasmatic nucleus (SCN) ensconced in the anterior hypothalamic region. The SCN, synchronized during daylight hours receives and transmits diverse bodily signals to calibrate physiological dynamics, and imbue disturbances with potential repercussions reverberating across a plethora of physiological and behavioral domains. Previous studies have proven that the diurnal changes in the circadian rhythm multiple myocardial processes and have a critical impact on the physiology and pathophysiology of the cardiovascular system. This comprehensive review emphasizes the profound influence of circadian rhythms, orchestrated by the suprachiasmatic nucleus, on cardiovascular health. It reveals that disruptions in circadian rhythms impact blood pressure, myocardial function, platelet responsiveness, and the autonomic nervous system, all of which are critical for cardiovascular well-being. The significance of this research lies in its potential to guide interventions for cardiovascular disease prevention and management, particularly in the context of modern challenges like shift work. Understanding this intricate relationship is crucial for safeguarding cardiovascular health in our fast-paced world.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240754
Yixin Xu
As an essential counterpart of the human internal environment, the gut microbiome has been investigated extensively in light of multiple diseases. This study aims to find out potential treatments for depression by altering gut microbiome composition in order to alleviate side effects caused by traditional medications. According to previous findings, the human gut correlates with the brain through pathways known as the gut-brain axis. Two genera of microbiome, Lactobacillus and Bifidobacterium, have been mentioned by researchers to be crucial to depression-related neurotransmitter secretion in GBA. Besides, they have already been used in clinical as effective probiotics for gut-related diseases. The paper hypothesized particular interactions between the two genera and the human nerve that enable them to be therapeutic cures in adequate amounts. In this study, a range of available single-cell data about depression and lactobacillus and bifidobacterium were analyzed and adjusted into proper figures. I discuss the efficacy of different species, concentrations, and other elements of those probiotics, eventually proposing a novel way of treating and classifying depressive disorders. The study puts forth a perspective of maintaining a depression-free state with an internal factor, the gut microbiome, instead of targeting the efferent neurons directly with external drugs which could cause resistance and severe side effects.
{"title":"Gut-to-brain axis provides novel therapeutic targets for depression","authors":"Yixin Xu","doi":"10.54254/2753-8818/29/20240754","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240754","url":null,"abstract":"As an essential counterpart of the human internal environment, the gut microbiome has been investigated extensively in light of multiple diseases. This study aims to find out potential treatments for depression by altering gut microbiome composition in order to alleviate side effects caused by traditional medications. According to previous findings, the human gut correlates with the brain through pathways known as the gut-brain axis. Two genera of microbiome, Lactobacillus and Bifidobacterium, have been mentioned by researchers to be crucial to depression-related neurotransmitter secretion in GBA. Besides, they have already been used in clinical as effective probiotics for gut-related diseases. The paper hypothesized particular interactions between the two genera and the human nerve that enable them to be therapeutic cures in adequate amounts. In this study, a range of available single-cell data about depression and lactobacillus and bifidobacterium were analyzed and adjusted into proper figures. I discuss the efficacy of different species, concentrations, and other elements of those probiotics, eventually proposing a novel way of treating and classifying depressive disorders. The study puts forth a perspective of maintaining a depression-free state with an internal factor, the gut microbiome, instead of targeting the efferent neurons directly with external drugs which could cause resistance and severe side effects.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"189 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240768
Yunlin Chen
With the development of science and technology and the maturity of technology, the application of 3D printing technology has developed from the art to the clinical medical treatment. Nowadays, the research and development and production of personalized customized orthopedic medical devices are possible, and the production line and supply chain of customized prostheses are constantly improving. The research on 3D printing and prosthesis customization technology is at the forefront of science. This article uses the method of literature review, reading, quoting, and summarizing several domestic and foreign professional experimental records and opinions, focusing on the history of 3D modeling and printing technology, the application method of this technology and the current clinical application of 3D modeling and printing technology. This paper puts forward reflection on the current shortcomings of the technology and my thinking and suggestions for future research. The conclusion of this paper is that 3D modeling and printing technology has played a great role in medical treatment, but there are still shortcomings in terms of cost and materials.
{"title":"Research on prosthesis customization with 3D modeling and printing technology","authors":"Yunlin Chen","doi":"10.54254/2753-8818/29/20240768","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240768","url":null,"abstract":"With the development of science and technology and the maturity of technology, the application of 3D printing technology has developed from the art to the clinical medical treatment. Nowadays, the research and development and production of personalized customized orthopedic medical devices are possible, and the production line and supply chain of customized prostheses are constantly improving. The research on 3D printing and prosthesis customization technology is at the forefront of science. This article uses the method of literature review, reading, quoting, and summarizing several domestic and foreign professional experimental records and opinions, focusing on the history of 3D modeling and printing technology, the application method of this technology and the current clinical application of 3D modeling and printing technology. This paper puts forward reflection on the current shortcomings of the technology and my thinking and suggestions for future research. The conclusion of this paper is that 3D modeling and printing technology has played a great role in medical treatment, but there are still shortcomings in terms of cost and materials.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"212 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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