Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240815
Siyuan Liu
With the change of time and the development of society, in recent years, the problem of depression among adolescents has attracted much attention in China and even in the world. Depression is a relatively common psychiatric disorder at this stage. Focusing on the clinical treatment methods of adolescent depression, this review summarizes and discusses the progress of psychotherapy, the progress of medication, and other physical therapy methods applied in todays clinic for treating adolescent patients with depression and finds that the psychotherapeutic method that is applied more in todays clinic is cognitive-behavioral therapy (CBT); medications such as fluoxetine are mostly used, but it is difficult to guarantee the safety of medication use, and the combination of Chinese and Western medications is often used in China. In China, a combination of Chinese and Western medicines is often used; at the same time, repetitive transcranial magnetic therapy is often used, and electroconvulsive therapy is occasionally used. At the same time, the combination of multiple therapies has a better effect.
{"title":"A review of research advances in the clinical management of adolescent depression","authors":"Siyuan Liu","doi":"10.54254/2753-8818/29/20240815","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240815","url":null,"abstract":"With the change of time and the development of society, in recent years, the problem of depression among adolescents has attracted much attention in China and even in the world. Depression is a relatively common psychiatric disorder at this stage. Focusing on the clinical treatment methods of adolescent depression, this review summarizes and discusses the progress of psychotherapy, the progress of medication, and other physical therapy methods applied in todays clinic for treating adolescent patients with depression and finds that the psychotherapeutic method that is applied more in todays clinic is cognitive-behavioral therapy (CBT); medications such as fluoxetine are mostly used, but it is difficult to guarantee the safety of medication use, and the combination of Chinese and Western medications is often used in China. In China, a combination of Chinese and Western medicines is often used; at the same time, repetitive transcranial magnetic therapy is often used, and electroconvulsive therapy is occasionally used. At the same time, the combination of multiple therapies has a better effect.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"165 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240755
Yuan Yuan
Confronted with the rapid need for transplantable hearts, patients who need a heart transplant cannot receive the suitable configuration. Thus contributes to the development of artificial hearts, which can be created to substitute the old, the ill heart without waiting for transplantable hearts. Nowadays, this paper shows the public the artificial hearts. Through the extensive literature, it is clear that the development of artificial hearts. Dating back to the fifties of the last century, scientists began studying artificial hearts. Till now, China has created four generations of artificial hearts. They became more and more strong. The importance of the heart goes without saying, however, every year there are more and more heart failure patients. Paying more attention to the artificial hearts helps reduce the death rate of heart failures. Actually, although the patients can get the heart donors, they may not tolerate rejection. So research into artificial hearts more suitable for patients is imminent. This paper mainly introduces the fourth-generation artificial hearts (in fact, it is an improved version of the third generation), the magnetic levitation artificial heart attracts much more attention, and its composition and function have been greatly improved, reducing the difficulty of surgery. It is hoped that people can know much more about artificial hearts, and prospects for better methods to make better artificial hearts, and promote heart transplantations.
{"title":"Analysis of the current status and development prospects of artificial hearts","authors":"Yuan Yuan","doi":"10.54254/2753-8818/29/20240755","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240755","url":null,"abstract":"Confronted with the rapid need for transplantable hearts, patients who need a heart transplant cannot receive the suitable configuration. Thus contributes to the development of artificial hearts, which can be created to substitute the old, the ill heart without waiting for transplantable hearts. Nowadays, this paper shows the public the artificial hearts. Through the extensive literature, it is clear that the development of artificial hearts. Dating back to the fifties of the last century, scientists began studying artificial hearts. Till now, China has created four generations of artificial hearts. They became more and more strong. The importance of the heart goes without saying, however, every year there are more and more heart failure patients. Paying more attention to the artificial hearts helps reduce the death rate of heart failures. Actually, although the patients can get the heart donors, they may not tolerate rejection. So research into artificial hearts more suitable for patients is imminent. This paper mainly introduces the fourth-generation artificial hearts (in fact, it is an improved version of the third generation), the magnetic levitation artificial heart attracts much more attention, and its composition and function have been greatly improved, reducing the difficulty of surgery. It is hoped that people can know much more about artificial hearts, and prospects for better methods to make better artificial hearts, and promote heart transplantations.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"80 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240847
Yihan Chang
With the in-depth development of population aging, the level of health reduction of the elderly groups sharply increased, the rapid aging of the population brought health problems became a major challenge of 21st-century Chinese society, how to healthy aging, continuously improve the health level of older people, improve the quality of life in old age, there is no doubt more holistic, targeted and innovative thinking. Several studies have proved that a healthy lifestyle can effectively improve the health of the elderly. However, a series of factors, such as poor sleep quality, continue to harm the health of the elderly, resulting in reduced quality of life. With the large scale and rapid aging, the proportion of the elderly in the population is also increasing. In an aging society, the biggest problems plaguing the elderly are the loss of sleep quality and the loss of memory and concentration. People may have sleep disorders as they get older, and sleep problems will affect memory. This study used literature research to summarize the relationship between population aging and sleep. Compared with previous studies, this paper is more targeted and comprehensive in explaining the relationship between the three from micro and macro perspectives: aging leads to changes in sleep structure and duration, which further affects memory ability.
{"title":"Research on the relationship between sleep and aging","authors":"Yihan Chang","doi":"10.54254/2753-8818/29/20240847","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240847","url":null,"abstract":"With the in-depth development of population aging, the level of health reduction of the elderly groups sharply increased, the rapid aging of the population brought health problems became a major challenge of 21st-century Chinese society, how to healthy aging, continuously improve the health level of older people, improve the quality of life in old age, there is no doubt more holistic, targeted and innovative thinking. Several studies have proved that a healthy lifestyle can effectively improve the health of the elderly. However, a series of factors, such as poor sleep quality, continue to harm the health of the elderly, resulting in reduced quality of life. With the large scale and rapid aging, the proportion of the elderly in the population is also increasing. In an aging society, the biggest problems plaguing the elderly are the loss of sleep quality and the loss of memory and concentration. People may have sleep disorders as they get older, and sleep problems will affect memory. This study used literature research to summarize the relationship between population aging and sleep. Compared with previous studies, this paper is more targeted and comprehensive in explaining the relationship between the three from micro and macro perspectives: aging leads to changes in sleep structure and duration, which further affects memory ability.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"44 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breast cancer has been recognized as the leading cancer worldwide and is one of the most common diseases among women, with an incidence rate of up to 7.7%. The pathogenesis of breast cancer can be categorized into congenital and acquired factors, including epigenetics and mutations. The occurrence of breast cancer is closely related to acquired factors such as environment, emotions, and diet. Numerous studies have demonstrated that L-theanine in tea can intervene in the growth and spread of breast cancer cells, thus playing a role in the treatment and prevention of breast cancer. This article provides an overview of the current research on the prevention and treatment of breast cancer using L-theanine, and also prospects the future development and application of L-theanine.
{"title":"L-theanine mechanism and application in the treatment of breast cancer","authors":"Cong Li, Renyue Cai, Linjiusheng Chen, Shizhen Xu, Xiaoyu Yang, Yixin Huang","doi":"10.54254/2753-8818/29/20240762","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240762","url":null,"abstract":"Breast cancer has been recognized as the leading cancer worldwide and is one of the most common diseases among women, with an incidence rate of up to 7.7%. The pathogenesis of breast cancer can be categorized into congenital and acquired factors, including epigenetics and mutations. The occurrence of breast cancer is closely related to acquired factors such as environment, emotions, and diet. Numerous studies have demonstrated that L-theanine in tea can intervene in the growth and spread of breast cancer cells, thus playing a role in the treatment and prevention of breast cancer. This article provides an overview of the current research on the prevention and treatment of breast cancer using L-theanine, and also prospects the future development and application of L-theanine.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"91 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240664
Xiaoying Liu
In recent years, Immune checkpoint inhibitors (ICIs) are being approved for the treatment of a wide range of malignancies, and they are one of the most popular immunotherapies for tumours, bringing new hope to patients. However, single-agent ICI therapy has limited efficacy and is prone to drug resistance, and the objective remission rate of ICI alone is only 10-20% in some tumours, therefore, how to improve clinical efficacy is the key point of clinical research associated with immunotherapy. New research has found that the combination of ICIs with differing mechanisms not only improves efficacy, but also prolongs the anti-tumour effect, while an appropriate dosing regimen can effectively balance efficacy and safety. It is proposed to review the mechanism, pharmacokinetics and clinical research progress of ICI combination therapy.
{"title":"Immune checkpoint inhibitor combination therapy","authors":"Xiaoying Liu","doi":"10.54254/2753-8818/29/20240664","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240664","url":null,"abstract":"In recent years, Immune checkpoint inhibitors (ICIs) are being approved for the treatment of a wide range of malignancies, and they are one of the most popular immunotherapies for tumours, bringing new hope to patients. However, single-agent ICI therapy has limited efficacy and is prone to drug resistance, and the objective remission rate of ICI alone is only 10-20% in some tumours, therefore, how to improve clinical efficacy is the key point of clinical research associated with immunotherapy. New research has found that the combination of ICIs with differing mechanisms not only improves efficacy, but also prolongs the anti-tumour effect, while an appropriate dosing regimen can effectively balance efficacy and safety. It is proposed to review the mechanism, pharmacokinetics and clinical research progress of ICI combination therapy.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"213 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240822
Yanbo Han
Obesity has become a global public health problem, which will negatively affect individual health along with the social economy, but there are fewer effective ways to control obesity and useful methods to prevent obesity from occurring. A data set about obesity rate was used as the basic data set, and the average obesity rate and BMI for each group were calculated using formulas of descriptive statistics. Then the results were shown through figures using the method of correlation analysis. Also, in addition, for a more comprehensive understanding of the differences between different regions, the study of Ward et al was also referred. Through analysis, obesity rates of adults in different age group in the U.S has a tendency of rising in recent years. There are also differences in obesity rates by various circumstances. In addition, there is a correlation between genetic factors, family environment, social impact, and obesity rates. And a high obesity rate will have bad effects on both adults in the society and the society itself. Obesity causes various impacts on adults over the age of 18 in America. And more usable and effective ways of dealing with obesity should be created.
{"title":"Obesity rates and its various impact to adults over the age of 18 in the United States","authors":"Yanbo Han","doi":"10.54254/2753-8818/29/20240822","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240822","url":null,"abstract":"Obesity has become a global public health problem, which will negatively affect individual health along with the social economy, but there are fewer effective ways to control obesity and useful methods to prevent obesity from occurring. A data set about obesity rate was used as the basic data set, and the average obesity rate and BMI for each group were calculated using formulas of descriptive statistics. Then the results were shown through figures using the method of correlation analysis. Also, in addition, for a more comprehensive understanding of the differences between different regions, the study of Ward et al was also referred. Through analysis, obesity rates of adults in different age group in the U.S has a tendency of rising in recent years. There are also differences in obesity rates by various circumstances. In addition, there is a correlation between genetic factors, family environment, social impact, and obesity rates. And a high obesity rate will have bad effects on both adults in the society and the society itself. Obesity causes various impacts on adults over the age of 18 in America. And more usable and effective ways of dealing with obesity should be created.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"114 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240827
Zhaoqi Wang
Over the last century, adult height has shown a marked increase, largely attributed to advancements in nutrition and healthcare. Monitoring child growth is crucial for the early identification of growth-related disorders. One such condition is the underperformance of the pituitary gland, which can lead to a deficiency in growth hormone, manifesting as short stature. Therapeutic interventions, such as growth hormone therapy and low-dose androgen therapy, have proven effective. These treatments utilize synthetic hormones to foster normal growth. Prompt and accurate diagnosis, coupled with precise treatment, is critical to empower individuals to reach their maximum growth potential and alleviate associated health concerns. Future research should aim to deepen our understanding of the interplay between pituitary cells, uncover additional genetic factors contributing to short stature, and enhance growth hormone replacement therapies. Such progress will significantly bolster the diagnostic and therapeutic strategies for children with growth impairments.
{"title":"Early diagnosis and treatment strategies for pediatric growth hormone deficiency","authors":"Zhaoqi Wang","doi":"10.54254/2753-8818/29/20240827","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240827","url":null,"abstract":"Over the last century, adult height has shown a marked increase, largely attributed to advancements in nutrition and healthcare. Monitoring child growth is crucial for the early identification of growth-related disorders. One such condition is the underperformance of the pituitary gland, which can lead to a deficiency in growth hormone, manifesting as short stature. Therapeutic interventions, such as growth hormone therapy and low-dose androgen therapy, have proven effective. These treatments utilize synthetic hormones to foster normal growth. Prompt and accurate diagnosis, coupled with precise treatment, is critical to empower individuals to reach their maximum growth potential and alleviate associated health concerns. Future research should aim to deepen our understanding of the interplay between pituitary cells, uncover additional genetic factors contributing to short stature, and enhance growth hormone replacement therapies. Such progress will significantly bolster the diagnostic and therapeutic strategies for children with growth impairments.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"147 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240749
Mingyuan Chen
The process of aging is what everyone is experiencing during the whole life. Many factors contribute to the aging process, among which the changes in mitochondrial structure and function are one important step. in this review, we elaborated on the relationship between mitochondria and aging from three aspects: the structure and function of mitochondria, the changes of mitochondria during aging, and the relationship between mitochondria and other organelles, we also described the progress related to mitochondrial targeted therapy. In summary, The passage highlights a review that examines the connection between mitochondria and aging from three main angles: understanding the structure and function of mitochondria, exploring how mitochondria change as an individual ages, and uncovering their relationships with other cellular organelles. Additionally, the passage discusses the advancements in mitochondrial targeted therapy within the context of aging.
{"title":"Mitochondria in aging: A review of structure, function, and interorganelle relationships","authors":"Mingyuan Chen","doi":"10.54254/2753-8818/29/20240749","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240749","url":null,"abstract":"The process of aging is what everyone is experiencing during the whole life. Many factors contribute to the aging process, among which the changes in mitochondrial structure and function are one important step. in this review, we elaborated on the relationship between mitochondria and aging from three aspects: the structure and function of mitochondria, the changes of mitochondria during aging, and the relationship between mitochondria and other organelles, we also described the progress related to mitochondrial targeted therapy. In summary, The passage highlights a review that examines the connection between mitochondria and aging from three main angles: understanding the structure and function of mitochondria, exploring how mitochondria change as an individual ages, and uncovering their relationships with other cellular organelles. Additionally, the passage discusses the advancements in mitochondrial targeted therapy within the context of aging.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"68 s278","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240763
Rui Cai
Whether from the perspective of impact scope or patient number, type 2 diabetes is one of the most influential diseases around the world today. However, in regards to type 2 diabetess pathology, scientists still could not provide an accurate explanation. In the long period of research, our understanding of the disease has already become deep enough to realize that type 2 diabetes is closely associated with genetics. This passage is based on this point of view and aims to take a glance at the polymorphism between genetic information of different racial/ethnic groups of people. From the analysis, it could be concluded that genetic polymorphism can provide useful information for the difference of pathology of patients, which could then inspire further drug development and more proper treatment scheme decision.
{"title":"Analysis on type 2 diabetes genetic polymorphism of different races/ethnicity","authors":"Rui Cai","doi":"10.54254/2753-8818/29/20240763","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240763","url":null,"abstract":"Whether from the perspective of impact scope or patient number, type 2 diabetes is one of the most influential diseases around the world today. However, in regards to type 2 diabetess pathology, scientists still could not provide an accurate explanation. In the long period of research, our understanding of the disease has already become deep enough to realize that type 2 diabetes is closely associated with genetics. This passage is based on this point of view and aims to take a glance at the polymorphism between genetic information of different racial/ethnic groups of people. From the analysis, it could be concluded that genetic polymorphism can provide useful information for the difference of pathology of patients, which could then inspire further drug development and more proper treatment scheme decision.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"46 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.54254/2753-8818/29/20240729
Xinyue Yao
The central nervous system (CNS) is a site for a myriad of disorders and diseases, such as schizophrenia, Alzheimers disease, and Parkinsons disease. Many medications targeting these illnesses remain challenged due to efflux transporters forming a blood-brain barrier (BBB). To combat such challenges, elacridar shown promise at inhibiting such transporters, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), therefore improving brain penetration. However, as an early clinical candidate, many remain unknown about elacridars pharmacokinetic (PK) properties in the human body. This paper aims to obtain a better understanding of elacridars pharmacokinetic profile and predict the optimal dose and dose interval for its application in the clinic. To begin with, a series of basic PK models were created using fundamental PK equations and the models were fit to elacridar clinical data to obtain elacridar-specific PK parameters. Next, elacridar preclinical PK as well as in vitro inhibition assay were used to determine the therapeutic window. Our final, multiple-dose extravascular PK model reveals that the most convenient and effective dose regimen is 900 mg BID (bis in die; twice per day). With this elacridar PK model, researchers can leverage elacridar human PK to improve clinical outcomes.
{"title":"Improving brain penetration using elacridara P-glycoprotein and BCRP inhibitor","authors":"Xinyue Yao","doi":"10.54254/2753-8818/29/20240729","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240729","url":null,"abstract":"The central nervous system (CNS) is a site for a myriad of disorders and diseases, such as schizophrenia, Alzheimers disease, and Parkinsons disease. Many medications targeting these illnesses remain challenged due to efflux transporters forming a blood-brain barrier (BBB). To combat such challenges, elacridar shown promise at inhibiting such transporters, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), therefore improving brain penetration. However, as an early clinical candidate, many remain unknown about elacridars pharmacokinetic (PK) properties in the human body. This paper aims to obtain a better understanding of elacridars pharmacokinetic profile and predict the optimal dose and dose interval for its application in the clinic. To begin with, a series of basic PK models were created using fundamental PK equations and the models were fit to elacridar clinical data to obtain elacridar-specific PK parameters. Next, elacridar preclinical PK as well as in vitro inhibition assay were used to determine the therapeutic window. Our final, multiple-dose extravascular PK model reveals that the most convenient and effective dose regimen is 900 mg BID (bis in die; twice per day). With this elacridar PK model, researchers can leverage elacridar human PK to improve clinical outcomes.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"3 s4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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