Pub Date : 2025-09-28DOI: 10.1016/j.oooo.2025.09.001
Serhat Can DDS , Sinem Büşra Kıraç Can DDS , Sultan Seren Karakuş MD , Gülcan Berkel MD
{"title":"Corrigendum to “Does the use of the levonorgestrel intrauterine system increase the prevalence of masticatory muscles tenderness?” [Oral Surg Oral Med Oral Pathol Oral Radiol. 140/4 (2025) Pages 384-390]","authors":"Serhat Can DDS , Sinem Büşra Kıraç Can DDS , Sultan Seren Karakuş MD , Gülcan Berkel MD","doi":"10.1016/j.oooo.2025.09.001","DOIUrl":"10.1016/j.oooo.2025.09.001","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 6","pages":"Page 814"},"PeriodicalIF":1.9,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-27DOI: 10.1016/j.oooo.2025.09.015
Pushkar Mehra DMD, MS, FACS , David B. Powers DMD, MD, FRCS, FACS , Deepak Kademani DMD, MD, FACS , Paul S. Tiwana DDS, MD, FACS
Oral and Maxillofacial Surgery (OMS) residency programs in the United States have recently experienced a notable decline in match rates. While it may be challenging to identify the root cause of this change, similar experiences in other specialties have identified contributing factors such as the increase in the number of residency positions, changes in specialty perception and workforce needs as contributing factors. This article examines the current state of OMS residency training and provides recommendations aimed to attract more people to the field, take a deeper dive into understanding of the factors contributing to changes in the specialty, and the development of evidence-based interventions.
{"title":"Perspective on trends in oral and maxillofacial surgery residency training and recent match results","authors":"Pushkar Mehra DMD, MS, FACS , David B. Powers DMD, MD, FRCS, FACS , Deepak Kademani DMD, MD, FACS , Paul S. Tiwana DDS, MD, FACS","doi":"10.1016/j.oooo.2025.09.015","DOIUrl":"10.1016/j.oooo.2025.09.015","url":null,"abstract":"<div><div>Oral and Maxillofacial Surgery (OMS) residency programs in the United States have recently experienced a notable decline in match rates. While it may be challenging to identify the root cause of this change, similar experiences in other specialties have identified contributing factors such as the increase in the number of residency positions, changes in specialty perception and workforce needs as contributing factors. This article examines the current state of OMS residency training and provides recommendations aimed to attract more people to the field, take a deeper dive into understanding of the factors contributing to changes in the specialty, and the development of evidence-based interventions.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 3","pages":"Pages 299-305"},"PeriodicalIF":1.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-25DOI: 10.1016/S2212-4403(25)01180-0
{"title":"Information for Readers","authors":"","doi":"10.1016/S2212-4403(25)01180-0","DOIUrl":"10.1016/S2212-4403(25)01180-0","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"140 5","pages":"Page A6"},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145128377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-25DOI: 10.1016/j.oooo.2025.09.014
Hianne Cristinne de Morais Medeiros DDS, MSc, PhD, Rani Iani Costa Gonçalo DDS, MSc, PhD, Carolina Maria Campos DDS, MSc, Maria Luiza Diniz de Sousa Lopes DDS, MSc, PhD, Lélia Batista de Souza DDS, MSc, PhD, Lélia Maria Guedes Queiroz DDS, MSc, PhD
Objectives
This study analyzed the immunoexpression of ING proteins in benign odontogenic lesions and dental follicles (DF), assessing interrelationships and correlations with p53, Bcl-2 and Bax.
Study Design
Twenty conventional ameloblastomas (AMB), 20 adenomatoid odontogenic tumors (AOT), 20 odontogenic keratocysts (OKC) and 10 DF were analyzed by immunohistochemistry for ING1–5, p53, Bcl-2, and Bax, considering cellular localization.
Results
ING2 was higher in DF, OKC, and AMB versus AOT (p < .0001). ING3 was lower in AMB versus DF (p = .003), and ING4 was reduced in OKC and AMB versus DF, and lower in AMB versus AOT (p < .0001). Nuclear/nuclear-cytoplasmic ING was predominant in DF, and cytoplasmic/nuclear-cytoplasmic expression in odontogenic lesions, especially OKC and AMB. ING proteins showed strong interrelationships, particularly among nuclear-cytoplasmic ING1/3/4 in DF, AOT, and AMB, with some negative correlations for nuclear-cytoplasmic versus cytoplasmic compartments (p < .05). Significant correlations with apoptosis-related markers were limited. Hierarchical clustering identified 3 molecular clusters, associated with different tissue types (p < .0001), reflecting combined ING expression patterns and apoptosis-related proteins.
Conclusions
Distinct molecular signatures of ING protein expression in odontogenic lesions reveal nuclear loss and cytoplasmic redistribution in OKC and AMB, suggesting coordinated involvement of these proteins in odontogenic lesion pathogenesis.
{"title":"Protein expression signatures of the ING family in benign odontogenic epithelial lesions","authors":"Hianne Cristinne de Morais Medeiros DDS, MSc, PhD, Rani Iani Costa Gonçalo DDS, MSc, PhD, Carolina Maria Campos DDS, MSc, Maria Luiza Diniz de Sousa Lopes DDS, MSc, PhD, Lélia Batista de Souza DDS, MSc, PhD, Lélia Maria Guedes Queiroz DDS, MSc, PhD","doi":"10.1016/j.oooo.2025.09.014","DOIUrl":"10.1016/j.oooo.2025.09.014","url":null,"abstract":"<div><h3>Objectives</h3><div>This study analyzed the immunoexpression of ING proteins in benign odontogenic lesions and dental follicles (DF), assessing interrelationships and correlations with p53, Bcl-2 and Bax.</div></div><div><h3>Study Design</h3><div>Twenty conventional ameloblastomas (AMB), 20 adenomatoid odontogenic tumors (AOT), 20 odontogenic keratocysts (OKC) and 10 DF were analyzed by immunohistochemistry for ING1–5, p53, Bcl-2, and Bax, considering cellular localization.</div></div><div><h3>Results</h3><div>ING2 was higher in DF, OKC, and AMB versus AOT (<em>p</em> < .0001). ING3 was lower in AMB versus DF (<em>p</em> = .003), and ING4 was reduced in OKC and AMB versus DF, and lower in AMB versus AOT (<em>p</em> < .0001). Nuclear/nuclear-cytoplasmic ING was predominant in DF, and cytoplasmic/nuclear-cytoplasmic expression in odontogenic lesions, especially OKC and AMB. ING proteins showed strong interrelationships, particularly among nuclear-cytoplasmic ING1/3/4 in DF, AOT, and AMB, with some negative correlations for nuclear-cytoplasmic versus cytoplasmic compartments (<em>p</em> < .05). Significant correlations with apoptosis-related markers were limited. Hierarchical clustering identified 3 molecular clusters, associated with different tissue types (<em>p</em> < .0001), reflecting combined ING expression patterns and apoptosis-related proteins.</div></div><div><h3>Conclusions</h3><div>Distinct molecular signatures of ING protein expression in odontogenic lesions reveal nuclear loss and cytoplasmic redistribution in OKC and AMB, suggesting coordinated involvement of these proteins in odontogenic lesion pathogenesis.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 3","pages":"Pages 367-378"},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-18DOI: 10.1016/j.oooo.2025.09.011
Maurília Raquel de Souto Medeiros PhD , Caio César da Silva Barros PhD , Elana Raquel de Oliveira Brito , Nicole Stheffany de Oliveira Alves , Patrícia Teixeira de Oliveira PhD , Éricka Janine Dantas da Silveira PhD
Background
Multinucleated giant cells (MGCs) can be involved in pathological processes in the oral and maxillofacial region. Oral and maxillofacial lesions that may show giant cells (OMLGC) exhibit diverse clinical characteristics and etiopathogenesis. This retrospective study analyzed the occurrence and clinicopathological characteristics of patients diagnosed with OMLGCs.
Material and Methods
Clinicopathological information was collected from biopsy records and histopathological reports of patients diagnosed with OMLGCs in a Brazilian Oral Pathology Service (1970-2023).
Results
Four hundred forty-one cases of OMLGCs were diagnosed. Of these, 59.4% (n = 262) were female, with a mean age of 31.2 ± 18.7 years. The peripheral giant cell granuloma was the most common in soft tissue (n = 169). Soft tissue OMLGCs affected the mandible's posterior gingiva/alveolar ridge (24.4%). In hard tissue, the most frequent lesion was the central giant cell granuloma (n = 104), and the posterior region of the mandible (42.2%) and maxilla (20.8%) were the most affected. Regarding the radiographic appearance, most cases were described as radiolucent (61.3%), well-defined (85.7%), and multilocular (60%).
Conclusions
Our study's findings contribute to a more comprehensive understanding of the epidemiological, clinical, and radiographic profile of OMLGCs, aiding in the differential diagnosis and management of these lesions in clinical practice.
{"title":"Characterization of oral and maxillofacial lesions that may exhibit giant cells: a retrospective study in a Brazilian population over 53 years","authors":"Maurília Raquel de Souto Medeiros PhD , Caio César da Silva Barros PhD , Elana Raquel de Oliveira Brito , Nicole Stheffany de Oliveira Alves , Patrícia Teixeira de Oliveira PhD , Éricka Janine Dantas da Silveira PhD","doi":"10.1016/j.oooo.2025.09.011","DOIUrl":"10.1016/j.oooo.2025.09.011","url":null,"abstract":"<div><h3>Background</h3><div>Multinucleated giant cells (MGCs) can be involved in pathological processes in the oral and maxillofacial region. Oral and maxillofacial lesions that may show giant cells (OMLGC) exhibit diverse clinical characteristics and etiopathogenesis. This retrospective study analyzed the occurrence and clinicopathological characteristics of patients diagnosed with OMLGCs.</div></div><div><h3>Material and Methods</h3><div>Clinicopathological information was collected from biopsy records and histopathological reports of patients diagnosed with OMLGCs in a Brazilian Oral Pathology Service (1970-2023).</div></div><div><h3>Results</h3><div>Four hundred forty-one cases of OMLGCs were diagnosed. Of these, 59.4% (n = 262) were female, with a mean age of 31.2 ± 18.7 years. The peripheral giant cell granuloma was the most common in soft tissue (n = 169). Soft tissue OMLGCs affected the mandible's posterior gingiva/alveolar ridge (24.4%). In hard tissue, the most frequent lesion was the central giant cell granuloma (n = 104), and the posterior region of the mandible (42.2%) and maxilla (20.8%) were the most affected. Regarding the radiographic appearance, most cases were described as radiolucent (61.3%), well-defined (85.7%), and multilocular (60%).</div></div><div><h3>Conclusions</h3><div>Our study's findings contribute to a more comprehensive understanding of the epidemiological, clinical, and radiographic profile of OMLGCs, aiding in the differential diagnosis and management of these lesions in clinical practice.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 229-238"},"PeriodicalIF":1.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-18DOI: 10.1016/j.oooo.2025.09.009
Allison M. Lee DDS, MS , John M. Wright DDS, MS , Celeste Abraham DDS, MS , Hua Zhang PhD, MD , Victoria L. Woo DDS
Objectives
This study describes observable trends in the epidemiological, histopathologic, and immunohistochemical characteristics of gingival SCCs.
Study design
A retrospective review was performed of the Texas A&M University’s Oral Pathology Biopsy Service database (2010-2020), yielding clinical and histopathologic information on 419 cases of gingival SCC. Fifteen cases were randomly selected for immunohistochemical studies using CK1/10 and CK19 to assess cellular origin.
Results
An increase in incidence of gingival SCC was observed over 10 years (R2 = 0.51), although this increase was less significant when adjusted for total biopsy volume (R2 = 0.29). The average age of diagnosis was 69.8 years, with the posterior mandibular gingiva being the most frequently affected site. The provisional diagnosis of SCC was given for 61% of cases. Among cases with available risk factor data, 62% reported a prior or current smoking history. Immunohistochemical staining revealed heterogeneous expression patterns with CK1/10 and CK19.
Conclusions
Gingival SCCs demonstrate a diverse clinical and histopathologic appearance and may be omitted in the clinical differential diagnosis in favor of reactive and inflammatory pathology. An increased awareness of the rising incidence of gingival SCCs may promote early clinical recognition and prevent potential delays in diagnosis and treatment.
{"title":"Gingival squamous cell carcinoma: an epidemiologic, histopathologic, and immunohistochemical study of 419 cases","authors":"Allison M. Lee DDS, MS , John M. Wright DDS, MS , Celeste Abraham DDS, MS , Hua Zhang PhD, MD , Victoria L. Woo DDS","doi":"10.1016/j.oooo.2025.09.009","DOIUrl":"10.1016/j.oooo.2025.09.009","url":null,"abstract":"<div><h3>Objectives</h3><div>This study describes observable trends in the epidemiological, histopathologic, and immunohistochemical characteristics of gingival SCCs.</div></div><div><h3>Study design</h3><div>A retrospective review was performed of the Texas A&M University’s Oral Pathology Biopsy Service database (2010-2020), yielding clinical and histopathologic information on 419 cases of gingival SCC. Fifteen cases were randomly selected for immunohistochemical studies using CK1/10 and CK19 to assess cellular origin.</div></div><div><h3>Results</h3><div>An increase in incidence of gingival SCC was observed over 10 years (R<sup>2</sup> = 0.51), although this increase was less significant when adjusted for total biopsy volume (R<sup>2</sup> = 0.29). The average age of diagnosis was 69.8 years, with the posterior mandibular gingiva being the most frequently affected site. The provisional diagnosis of SCC was given for 61% of cases. Among cases with available risk factor data, 62% reported a prior or current smoking history. Immunohistochemical staining revealed heterogeneous expression patterns with CK1/10 and CK19.</div></div><div><h3>Conclusions</h3><div>Gingival SCCs demonstrate a diverse clinical and histopathologic appearance and may be omitted in the clinical differential diagnosis in favor of reactive and inflammatory pathology. An increased awareness of the rising incidence of gingival SCCs may promote early clinical recognition and prevent potential delays in diagnosis and treatment.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 218-228"},"PeriodicalIF":1.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-18DOI: 10.1016/j.oooo.2025.09.003
Sarah G. Fitzpatrick DDS , Kurt F. Summersgill DDS, PhD , Nidhi Q. Handoo BDS, MS , Brent Accurso DDS, MPH , Molly Housley Smith DMD , Alan R. Gould DDS, MS , Austin Belknap DMD , Robert D. Kelsch DMD , Jill M. Kramer DDS, PhD
{"title":"Diversity of career paths in oral and maxillofacial pathology: a panel discussion of advantages, challenges, and advice for residents","authors":"Sarah G. Fitzpatrick DDS , Kurt F. Summersgill DDS, PhD , Nidhi Q. Handoo BDS, MS , Brent Accurso DDS, MPH , Molly Housley Smith DMD , Alan R. Gould DDS, MS , Austin Belknap DMD , Robert D. Kelsch DMD , Jill M. Kramer DDS, PhD","doi":"10.1016/j.oooo.2025.09.003","DOIUrl":"10.1016/j.oooo.2025.09.003","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 1","pages":"Pages 1-7"},"PeriodicalIF":1.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145427094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-17DOI: 10.1016/j.oooo.2025.09.007
Michelle Briner DDS , Jean-Marc Retrouvey DMD, MSc , Members of BBDC
Objectives
To evaluate mandibular condylar volume and height in individuals with osteogenesis imperfecta (OI) compared to age- and sex-matched controls using CBCTs.
Study Design
This study included 48 OI patients and 48 matched controls. CBCTs were analyzed using 3DSlicer and Anatomage-InVivo6 software. Condylar volume and height were measured bilaterally. Data were analyzed using t-tests, ANOVA, and Tukey posthoc tests.
Results
No sex-based differences in condylar volume were found in either OI or control patients. Volumetric developmental stage differences were significant only in OI patients. In OI patients, condylar height was significantly associated with sex on the right side only. In controls, no sex-based differences were found, but developmental stage differences were significant in the left condyle. No significant differences in volume or height were observed between OI types.
Conclusion
Individuals with OI, show significantly reduced condylar volume and height, indicating impaired and delayed condylar development consistent with their overall skeletal maturation delay.
{"title":"Quantitative assessment of the temporomandibular joints in patients with osteogenesis imperfecta: a CBCT study","authors":"Michelle Briner DDS , Jean-Marc Retrouvey DMD, MSc , Members of BBDC","doi":"10.1016/j.oooo.2025.09.007","DOIUrl":"10.1016/j.oooo.2025.09.007","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate mandibular condylar volume and height in individuals with osteogenesis imperfecta (OI) compared to age- and sex-matched controls using CBCTs.</div></div><div><h3>Study Design</h3><div>This study included 48 OI patients and 48 matched controls. CBCTs were analyzed using 3DSlicer and Anatomage-InVivo6 software. Condylar volume and height were measured bilaterally. Data were analyzed using t-tests, ANOVA, and Tukey posthoc tests.</div></div><div><h3>Results</h3><div>No sex-based differences in condylar volume were found in either OI or control patients. Volumetric developmental stage differences were significant only in OI patients. In OI patients, condylar height was significantly associated with sex on the right side only. In controls, no sex-based differences were found, but developmental stage differences were significant in the left condyle. No significant differences in volume or height were observed between OI types.</div></div><div><h3>Conclusion</h3><div>Individuals with OI, show significantly reduced condylar volume and height, indicating impaired and delayed condylar development consistent with their overall skeletal maturation delay.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 1","pages":"Pages 116-125"},"PeriodicalIF":1.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-17DOI: 10.1016/j.oooo.2025.09.008
Haoyu Xu MD, DDS , Lei Yin MD , Kuankuan Jia MD, DDS , Yan Fan MD , Jingang An MD, DDS
Objectives
To compare the characteristics of patients with isolated diffuse sclerosing osteomyelitis of the mandible (DSOM) and those with DSOM along with systemic bone, joint, and cutaneous lesions, and discuss the relationship between DSOM and the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome from the perspective of oral and maxillofacial surgery.
Study design
A total of 446 DSOM patients were included. They were divided into simple DSOM and syndrome-type DSOM groups based on their systemic manifestations. Their demographic data, clinical features, imaging findings (maxillofacial CT and bone scintigraphy), and laboratory results (bone turnover markers (BTMs) and inflammatory markers) were compared.
Results
Compared to patients with syndrome-type DSOM, those with simple DSOM had a younger median age of onset (13 vs 25 years), a higher proportion of women (69.8% vs 45.5%), lower bilateral mandibular involvement (18.3% vs 29.9%), a higher prevalence of periosteal reaction (70.6% vs 59.7%, p = .017), elevated BTMs (osteocalcin: 49.73 vs 21.69 ng/mL; β-CTX: 0.94 vs 0.53 ng/mL), and lower C-reactive protein levels (3.00 vs 7.48 mg/L).
Conclusion
Nearly half of all patients with DSOM exhibited systemic bone, joint, or cutaneous manifestations. The characteristics of simple DSOM and syndrome-type DSOM are highly overlapped, but the differences in age, gender distribution, radiographic findings and bone metabolic activity suggest that they may be different stages or subtypes of the same disease.
目的：比较单纯性弥漫性硬化性下颌骨骨髓炎（DSOM）患者与伴有全身骨、关节、皮肤病变患者的特点，并从口腔颌面外科角度探讨DSOM与滑膜炎、痤疮、脓疱、骨质增生、骨炎（SAPHO）综合征的关系。研究设计：共纳入446例DSOM患者。根据其全身表现分为单纯性DSOM组和综合征型DSOM组。比较他们的人口学资料、临床特征、影像学表现（颌面CT和骨显像）和实验室结果（骨转换标志物（BTMs）和炎症标志物）。结果：与综合征型DSOM患者相比，单纯性DSOM患者的中位发病年龄较年轻（13岁vs 25岁），女性比例较高（69.8% vs 45.5%），双侧下颌受累较低（18.3% vs 29.9%），骨膜反应发生率较高（70.6% vs 59.7%, p = 0.017）， BTMs升高（骨钙素：49.73 vs 21.69 ng/mL; β-CTX: 0.94 vs 0.53 ng/mL）， c反应蛋白水平较低（3.00 vs 7.48 mg/L）。结论：近一半的DSOM患者表现出全身骨、关节或皮肤表现。单纯性DSOM和综合征型DSOM的特征高度重叠，但年龄、性别分布、影像学表现和骨代谢活动的差异提示它们可能是同一疾病的不同分期或亚型。
{"title":"The SAPHO syndrome in diffuse sclerosing osteomyelitis of the mandible: an oral and maxillofacial surgery perspective","authors":"Haoyu Xu MD, DDS , Lei Yin MD , Kuankuan Jia MD, DDS , Yan Fan MD , Jingang An MD, DDS","doi":"10.1016/j.oooo.2025.09.008","DOIUrl":"10.1016/j.oooo.2025.09.008","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the characteristics of patients with isolated diffuse sclerosing osteomyelitis of the mandible (DSOM) and those with DSOM along with systemic bone, joint, and cutaneous lesions, and discuss the relationship between DSOM and the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome from the perspective of oral and maxillofacial surgery.</div></div><div><h3>Study design</h3><div>A total of 446 DSOM patients were included. They were divided into simple DSOM and syndrome-type DSOM groups based on their systemic manifestations. Their demographic data, clinical features, imaging findings (maxillofacial CT and bone scintigraphy), and laboratory results (bone turnover markers (BTMs) and inflammatory markers) were compared.</div></div><div><h3>Results</h3><div>Compared to patients with syndrome-type DSOM, those with simple DSOM had a younger median age of onset (13 vs 25 years), a higher proportion of women (69.8% vs 45.5%), lower bilateral mandibular involvement (18.3% vs 29.9%), a higher prevalence of periosteal reaction (70.6% vs 59.7%, <em>p</em> = .017), elevated BTMs (osteocalcin: 49.73 vs 21.69 ng/mL; β-CTX: 0.94 vs 0.53 ng/mL), and lower C-reactive protein levels (3.00 vs 7.48 mg/L).</div></div><div><h3>Conclusion</h3><div>Nearly half of all patients with DSOM exhibited systemic bone, joint, or cutaneous manifestations. The characteristics of simple DSOM and syndrome-type DSOM are highly overlapped, but the differences in age, gender distribution, radiographic findings and bone metabolic activity suggest that they may be different stages or subtypes of the same disease.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 3","pages":"Pages 313-322"},"PeriodicalIF":1.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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