Despite rare reports of hybrid tumors containing cemento-ossifying fibroma (COF), its association with florid cemento-osseous dysplasia (FCOD) is very rare. A 38-year-old female presented for treatment of an expansive, tumoral lesion extending from the right mandibular lateral incisor to the first molar. Clinical examination revealed a significant bulging of the vestibular and lingual mandible cortices. CT scans revealed a hypodense, unilocular lesion that was relatively well-demarcated. Also, multiple mixed hyperdense/hypodense lesions were observed in the alveolar process of the jaws. An incisional biopsy was performed, and the microscopic features, together with the clinic-radiologic evaluation, were consistent with the diagnosis of COF. The tumor was resected, and the histopathological analysis confirmed the diagnosis. In continuity with the tumor, trabeculae of osteocementoid material were observed, which were likely related to the FCOD noted in the CT scan. Clinical, surgical, radiologic, and microscopic features supported the final diagnosis of a hybrid lesion, exhibiting characteristics of both COF associated with FCOD. There are no signs of recurrence after two years of follow-up.
{"title":"Cemento-osseous dysplasia with concomitant cemento-ossifying fibroma: a rare case report","authors":"Marina Rocha Fonseca Souza DDS, MSc , Marina Guimarães Fraga DDS , Roberta Rayra Martins Chaves DDS, PhD , Ricardo Santiago Gomez DDS, PhD","doi":"10.1016/j.oooo.2025.10.008","DOIUrl":"10.1016/j.oooo.2025.10.008","url":null,"abstract":"<div><div>Despite rare reports of hybrid tumors containing cemento-ossifying fibroma (COF), its association with florid cemento-osseous dysplasia (FCOD) is very rare. A 38-year-old female presented for treatment of an expansive, tumoral lesion extending from the right mandibular lateral incisor to the first molar. Clinical examination revealed a significant bulging of the vestibular and lingual mandible cortices. CT scans revealed a hypodense, unilocular lesion that was relatively well-demarcated. Also, multiple mixed hyperdense/hypodense lesions were observed in the alveolar process of the jaws. An incisional biopsy was performed, and the microscopic features, together with the clinic-radiologic evaluation, were consistent with the diagnosis of COF. The tumor was resected, and the histopathological analysis confirmed the diagnosis. In continuity with the tumor, trabeculae of osteocementoid material were observed, which were likely related to the FCOD noted in the CT scan. Clinical, surgical, radiologic, and microscopic features supported the final diagnosis of a hybrid lesion, exhibiting characteristics of both COF associated with FCOD. There are no signs of recurrence after two years of follow-up.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages e10-e14"},"PeriodicalIF":1.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-24DOI: 10.1016/j.oooo.2025.10.009
Melanie E. Miller MS , William R. Bowling MS , Tyrone F. Borders MS, PhD , Nayeon Kim MS , Ian A. Boggero PhD
Objective
Physical Self-Regulation (PSR) is a brief psychological intervention with demonstrated efficacy for use with orofacial pain populations, but it is unclear whether patients find PSR feasible when delivered via telehealth. Our aim was to evaluate the feasibility, acceptability, and satisfaction of PSR via telehealth among treatment-seeking adults with chronic orofacial pain.
Study Design
A convergent mixed-methods design was used. Twenty-eight treatment-seeking adults were recruited from a university-affiliated orofacial pain clinic and received three telehealth-delivered PSR sessions. Twenty-two completed all three sessions and eighteen also completed qualitative interviews. Measures of feasibility (Treatment Evaluation Questionnaire) and acceptability/adherence (Treatment Acceptability and Adherence Scale) were completed after sessions 1 and 2. Satisfaction (Treatment Satisfaction Questionnaire) was completed after session 3. Interviews explored participant’s experiences and were analyzed using content analysis.
Results
Participants reported high perceived feasibility and acceptability/adherence at all timepoints. Perceived feasibility improved from PSR session 1 to session 2 (P = .022). Following session 3, participants reported high satisfaction (M=3.59/4.00). Qualitative findings identified five themes: initial skepticism followed by optimism, improved functioning, convenience, low prior awareness of PSR, and feelings of empowerment.
Conclusions
Telehealth-delivered PSR was perceived as feasible, acceptable, and satisfying, supporting PSR’s potential as an implementable and scalable adjuvant telehealth therapy.
{"title":"Patient-reported feasibility, acceptability, and satisfaction of psychological telehealth orofacial pain interventions: a mixed-methods study","authors":"Melanie E. Miller MS , William R. Bowling MS , Tyrone F. Borders MS, PhD , Nayeon Kim MS , Ian A. Boggero PhD","doi":"10.1016/j.oooo.2025.10.009","DOIUrl":"10.1016/j.oooo.2025.10.009","url":null,"abstract":"<div><h3>Objective</h3><div>Physical Self-Regulation (PSR) is a brief psychological intervention with demonstrated efficacy for use with orofacial pain populations, but it is unclear whether patients find PSR feasible when delivered via telehealth. Our aim was to evaluate the feasibility, acceptability, and satisfaction of PSR via telehealth among treatment-seeking adults with chronic orofacial pain.</div></div><div><h3>Study Design</h3><div>A convergent mixed-methods design was used. Twenty-eight treatment-seeking adults were recruited from a university-affiliated orofacial pain clinic and received three telehealth-delivered PSR sessions. Twenty-two completed all three sessions and eighteen also completed qualitative interviews. Measures of feasibility (Treatment Evaluation Questionnaire) and acceptability/adherence (Treatment Acceptability and Adherence Scale) were completed after sessions 1 and 2. Satisfaction (Treatment Satisfaction Questionnaire) was completed after session 3. Interviews explored participant’s experiences and were analyzed using content analysis.</div></div><div><h3>Results</h3><div>Participants reported high perceived feasibility and acceptability/adherence at all timepoints. Perceived feasibility improved from PSR session 1 to session 2 (<em>P = .0</em>22). Following session 3, participants reported high satisfaction (M=3.59/4.00). Qualitative findings identified five themes: initial skepticism followed by optimism, improved functioning, convenience, low prior awareness of PSR, and feelings of empowerment.</div></div><div><h3>Conclusions</h3><div>Telehealth-delivered PSR was perceived as feasible, acceptable, and satisfying, supporting PSR’s potential as an implementable and scalable adjuvant telehealth therapy.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 3","pages":"Pages 334-342"},"PeriodicalIF":1.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-24DOI: 10.1016/j.oooo.2025.10.010
Mateus José Dutra , Lucas Freitas Carnevali , Lauren Frenzel Schuch , Felipe Martins Silveira , Alan Roger Santos-Silva , Manoela Domingues Martins , Vivian Petersen Wagner
Objectives
To map the landscape of non-profit groups or organizations (NPGorO) in the Ibero-American Region (IAR) supporting patients with head and neck cancer (HNC) and identify and characterize their main activities.
Study Design
A scoping review was conducted through PubMed, LILACS, Scielo, Google Scholar, ProQuest, and open databases. Articles mentioning any NPGorO related to HNC or thyroid cancer in the IAR were included, despite their differing epidemiology and clinical context.
Results
Nineteen NPGorO were identified: 3 in Brazil and Spain (15.78% each), 2 in Argentina and Chile (10.52% each). Other 9 countries each had one organization (5.26%). Most were founded by patients and family members (n = 13; 68.42%). Most websites (n = 18; 94.73%) provided information on risk factors, signs, symptoms, screening, diagnosis, and treatment. 16 NPGorO (84.21%) had a Facebook page, and fewer than half were on other social media.
Conclusions
NPGorO play a key social role in IAR countries, yet many, especially in Latin America, still lack advocacy groups for patients facing diagnostic and treatment disparities. Beyond support, these organizations can provide clinicians with patient guidance and serve as platforms for researchers to engage patient populations and promote study participation.
{"title":"Mapping Ibero-American nonprofit efforts in advocacy for head and neck cancer patients: a scoping review","authors":"Mateus José Dutra , Lucas Freitas Carnevali , Lauren Frenzel Schuch , Felipe Martins Silveira , Alan Roger Santos-Silva , Manoela Domingues Martins , Vivian Petersen Wagner","doi":"10.1016/j.oooo.2025.10.010","DOIUrl":"10.1016/j.oooo.2025.10.010","url":null,"abstract":"<div><h3>Objectives</h3><div>To map the landscape of non-profit groups or organizations (NPGorO) in the Ibero-American Region (IAR) supporting patients with head and neck cancer (HNC) and identify and characterize their main activities.</div></div><div><h3>Study Design</h3><div>A scoping review was conducted through PubMed, LILACS, Scielo, Google Scholar, ProQuest, and open databases. Articles mentioning any NPGorO related to HNC or thyroid cancer in the IAR were included, despite their differing epidemiology and clinical context.</div></div><div><h3>Results</h3><div>Nineteen NPGorO were identified: 3 in Brazil and Spain (15.78% each), 2 in Argentina and Chile (10.52% each). Other 9 countries each had one organization (5.26%). Most were founded by patients and family members (n = 13; 68.42%). Most websites (n = 18; 94.73%) provided information on risk factors, signs, symptoms, screening, diagnosis, and treatment. 16 NPGorO (84.21%) had a Facebook page, and fewer than half were on other social media.</div></div><div><h3>Conclusions</h3><div>NPGorO play a key social role in IAR countries, yet many, especially in Latin America, still lack advocacy groups for patients facing diagnostic and treatment disparities. Beyond support, these organizations can provide clinicians with patient guidance and serve as platforms for researchers to engage patient populations and promote study participation.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 3","pages":"Pages 343-350"},"PeriodicalIF":1.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-18DOI: 10.1016/j.oooo.2025.10.004
Déborah Dayely Silveira de Oliveira, Andréia Bufalino, Elaine Maria Sgavioli Massucato, Héric de Souza Camargo, Mariana Paravani Palaçon, Cláudia Maria Navarro
Objective: This retrospective cross-sectional study aimed to evaluate whether patients diagnosed with Sjögren's Disease (SjD) after the COVID-19 pandemic exhibited different clinical features compared to those diagnosed before the pandemic.
Methods: A total of 24 medical records from the Oral Medicine Service of Araraquara dental school - UNESP were analyzed. Patients were diagnosed according to ACR/EULAR criteria. Fourteen patients diagnosed BETWEEN 2022 AND 2024, all with a history of COVID-19, were compared to ten patients diagnosed between 2002 and 2019. DATA on sociodemographic characteristics, systemic comorbidities, subjective symptoms, and histopathological findings were collected and statistically analyzed.
Results: An increase in the number of SjD diagnoses was observed after 2022. The post-COVID group showed a significantly higher frequency of anxiety, fatigue, memory and concentration problems, genital dryness, dysphagia, insomnia, reflux, and oral burning. No significant differences were found in objective histopathological findings between the groups.
Conclusion: These findings suggest that SARS-CoV-2 infection may be associated with an increased prevalence of subjective symptoms in patients with SjD. Further prospective studies with larger sample sizes and control groups are warranted to clarify these associations and their clinical relevance.
{"title":"Clinical features and their incidence in Sjögren's patients with a history of COVID-19: a single-center retrospective study.","authors":"Déborah Dayely Silveira de Oliveira, Andréia Bufalino, Elaine Maria Sgavioli Massucato, Héric de Souza Camargo, Mariana Paravani Palaçon, Cláudia Maria Navarro","doi":"10.1016/j.oooo.2025.10.004","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.10.004","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective cross-sectional study aimed to evaluate whether patients diagnosed with Sjögren's Disease (SjD) after the COVID-19 pandemic exhibited different clinical features compared to those diagnosed before the pandemic.</p><p><strong>Methods: </strong>A total of 24 medical records from the Oral Medicine Service of Araraquara dental school - UNESP were analyzed. Patients were diagnosed according to ACR/EULAR criteria. Fourteen patients diagnosed BETWEEN 2022 AND 2024, all with a history of COVID-19, were compared to ten patients diagnosed between 2002 and 2019. DATA on sociodemographic characteristics, systemic comorbidities, subjective symptoms, and histopathological findings were collected and statistically analyzed.</p><p><strong>Results: </strong>An increase in the number of SjD diagnoses was observed after 2022. The post-COVID group showed a significantly higher frequency of anxiety, fatigue, memory and concentration problems, genital dryness, dysphagia, insomnia, reflux, and oral burning. No significant differences were found in objective histopathological findings between the groups.</p><p><strong>Conclusion: </strong>These findings suggest that SARS-CoV-2 infection may be associated with an increased prevalence of subjective symptoms in patients with SjD. Further prospective studies with larger sample sizes and control groups are warranted to clarify these associations and their clinical relevance.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-17DOI: 10.1016/j.oooo.2025.10.003
Punnya V Angadi, Deepa R Mane
Objective: The Glasgow Microenvironment Score (GMS) combines the tumor stroma percentage (TSP) with the inflammatory component of the tumor microenvironment and has demonstrated prognostic significance in several malignancies. This study explored the prognostic significance of the GMS in oral squamous cell carcinoma (OSCC).
Study design: Sixty patients with OSCC were examined for Klintrup-Makinen grade (KM) and TSP, which were then merged to generate a GMS. Ki-67 immunohistochemistry was performed to assess cellular proliferation. Clinicopathological characteristics and lymph node metastases were assessed using univariate and multivariate analyses.
Results: The GMS score indicated that 27 (45%) cases were categorized as 0-KM strong, 10 (16.7%) as 1-KM weak/low TSP, and 23 (38.3%) as 2-KM weak/high TSP. A high GMS score (grade 2) was associated with the depth of invasion, increased Ki-67 index, low KM grade, and high TSP. It also showed a strong correlation with lymph node metastases and was identified as an independent prognostic indicator (OR: 22.0, CI: 2.97-163.21).
Conclusion: The GMS, a cumulative scoring system for the tumor microenvironment, can be easily evaluated on standard H and E sections without the need for additional staining. A high GMS score, marked by elevated TSP and reduced inflammatory infiltration, emerged as a robust independent predictor of lymph node metastasis.
{"title":"Prognostic significance of the Glasgow Microenvironment Score for lymph node metastasis in oral squamous cell carcinoma.","authors":"Punnya V Angadi, Deepa R Mane","doi":"10.1016/j.oooo.2025.10.003","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.10.003","url":null,"abstract":"<p><strong>Objective: </strong>The Glasgow Microenvironment Score (GMS) combines the tumor stroma percentage (TSP) with the inflammatory component of the tumor microenvironment and has demonstrated prognostic significance in several malignancies. This study explored the prognostic significance of the GMS in oral squamous cell carcinoma (OSCC).</p><p><strong>Study design: </strong>Sixty patients with OSCC were examined for Klintrup-Makinen grade (KM) and TSP, which were then merged to generate a GMS. Ki-67 immunohistochemistry was performed to assess cellular proliferation. Clinicopathological characteristics and lymph node metastases were assessed using univariate and multivariate analyses.</p><p><strong>Results: </strong>The GMS score indicated that 27 (45%) cases were categorized as 0-KM strong, 10 (16.7%) as 1-KM weak/low TSP, and 23 (38.3%) as 2-KM weak/high TSP. A high GMS score (grade 2) was associated with the depth of invasion, increased Ki-67 index, low KM grade, and high TSP. It also showed a strong correlation with lymph node metastases and was identified as an independent prognostic indicator (OR: 22.0, CI: 2.97-163.21).</p><p><strong>Conclusion: </strong>The GMS, a cumulative scoring system for the tumor microenvironment, can be easily evaluated on standard H and E sections without the need for additional staining. A high GMS score, marked by elevated TSP and reduced inflammatory infiltration, emerged as a robust independent predictor of lymph node metastasis.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Germany lives in a world without oral pathologists: what are the consequences?","authors":"Poramate Pitak-Arnnop MD, DDS, MSc, PhD, DSc, FEBOMFS, FICS, FRSM","doi":"10.1016/j.oooo.2025.09.023","DOIUrl":"10.1016/j.oooo.2025.09.023","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 265-267"},"PeriodicalIF":1.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-17DOI: 10.1016/j.oooo.2025.10.001
Steven Dorris DDS, MS , Sindhura Anamali BDS, MS , Juan P. Castro DDS, MS , Shareef M. Dabdoub PhD , Trishul Allareddy BDS, MS, MBA
Objective
To evaluate the performance of commercially available AI tools in airway evaluation in clinical conditions.
Study Design
100 anonymized cone beam computed tomography datasets obtained from the records of the University of Iowa were oriented and analyzed by 2 calibrated oral and maxillofacial radiology residents using InVivo software (InVivo6). Measurements made were total airway volume and minimum cross-sectional surface area of the airway. These measurements were then compared to those produced by uploading the same datasets to Diagnocat AI software (Diagnocat).
Results
The results indicate that all comparisons showed good to excellent reliability (ICC > 0.75), suggesting high agreement between raters. Specifically: The intraclass correlation coefficients of 0.954 (CI: 0.757–0.983) and .944 (CI: 0.732–0.978) between the human and Diagnocat measurements indicate excellent reliability.
Conclusion
Diagnocat (Diagnocat) artificial intelligence software is capable of analyzing patients’ oropharyngeal airway volume and minimum cross-sectional area in cone beam computed tomography datasets with minimal to moderate motion artifact at a level comparable to qualified human practitioners.
{"title":"Comparisons of the reliability of airway measurements on cone beam computed tomography scans among human raters and a convolutional neural network","authors":"Steven Dorris DDS, MS , Sindhura Anamali BDS, MS , Juan P. Castro DDS, MS , Shareef M. Dabdoub PhD , Trishul Allareddy BDS, MS, MBA","doi":"10.1016/j.oooo.2025.10.001","DOIUrl":"10.1016/j.oooo.2025.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the performance of commercially available AI tools in airway evaluation in clinical conditions.</div></div><div><h3>Study Design</h3><div>100 anonymized cone beam computed tomography datasets obtained from the records of the University of Iowa were oriented and analyzed by 2 calibrated oral and maxillofacial radiology residents using InVivo software (InVivo6). Measurements made were total airway volume and minimum cross-sectional surface area of the airway. These measurements were then compared to those produced by uploading the same datasets to Diagnocat AI software (Diagnocat).</div></div><div><h3>Results</h3><div>The results indicate that all comparisons showed good to excellent reliability (ICC > 0.75), suggesting high agreement between raters. Specifically: The intraclass correlation coefficients of 0.954 (CI: 0.757–0.983) and .944 (CI: 0.732–0.978) between the human and Diagnocat measurements indicate excellent reliability.</div></div><div><h3>Conclusion</h3><div>Diagnocat (Diagnocat) artificial intelligence software is capable of analyzing patients’ oropharyngeal airway volume and minimum cross-sectional area in cone beam computed tomography datasets with minimal to moderate motion artifact at a level comparable to qualified human practitioners.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 2","pages":"Pages 255-264"},"PeriodicalIF":1.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-16DOI: 10.1016/j.oooo.2025.10.002
Xu Liu, Haiyan Wang, Quantong Zhao, Ran Wang, Hongshi Cao
Objectives: The objective of this systematic review and meta-analysis was to assess the effectiveness of virtual reality interventions in alleviating intraoperative pain and anxiety among adult patients undergoing oral surgical procedures.
Study design: From the database's creation until Feb 2, 2025, a thorough search was carried out across 13 electronic databases. Anxiety and pain throughout the procedure were important outcomes. The combined impacts were assessed using a random-effects model, with subgroup analyses looking into possible contributing variables. The risk of bias was evaluated using the Cochrane Risk of Bias 2 method.
Results: A total of 9 articles were eventually included in the study selection. Results of the meta-analysis reveal a statistically significant effect of virtual reality in reducing intraoperative anxiety in adults undergoing oral surgery (SMD = -0.26, 95% CI: (-0.48, -0.03), P < .05). Statistically significant effect in reducing intraoperative pain in adult oral surgery (SMD= -0.67, 95% CI: (-1.08, -0.26), P < .01).
Conclusions: This meta-analysis confirms the value of virtual reality in terms of oral surgery by distracting adult patients from intraoperative anxiety and pain. However, more high-quality, multicenter, and large-sample randomized controlled trials are needed to further assess its clinical value in the future.
目的：本系统综述和荟萃分析的目的是评估虚拟现实干预在减轻接受口腔外科手术的成年患者术中疼痛和焦虑方面的有效性。研究设计：从数据库创建到2025年2月2日，在13个电子数据库中进行了彻底的搜索。整个手术过程中的焦虑和疼痛是重要的结果。使用随机效应模型评估综合影响，并通过亚组分析寻找可能的影响变量。采用Cochrane risk of bias 2方法评估偏倚风险。结果：最终共有9篇文章被纳入研究选择。meta分析结果显示，虚拟现实在减少成人口腔手术患者术中焦虑方面具有统计学意义（SMD = -0.26, 95% CI: (-0.48, -0.03), P < 0.05）。成人口腔手术对减轻术中疼痛有统计学意义（SMD= -0.67, 95% CI: (-1.08, -0.26), P < 0.01）。结论：本荟萃分析证实了虚拟现实在口腔手术方面的价值，它可以分散成年患者术中焦虑和疼痛的注意力。然而，未来需要更多高质量、多中心、大样本的随机对照试验来进一步评估其临床价值。
{"title":"The effectiveness of virtual reality in relieving anxiety and pain for adult oral surgical procedures patients: a systematic review and meta-analysis.","authors":"Xu Liu, Haiyan Wang, Quantong Zhao, Ran Wang, Hongshi Cao","doi":"10.1016/j.oooo.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.10.002","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this systematic review and meta-analysis was to assess the effectiveness of virtual reality interventions in alleviating intraoperative pain and anxiety among adult patients undergoing oral surgical procedures.</p><p><strong>Study design: </strong>From the database's creation until Feb 2, 2025, a thorough search was carried out across 13 electronic databases. Anxiety and pain throughout the procedure were important outcomes. The combined impacts were assessed using a random-effects model, with subgroup analyses looking into possible contributing variables. The risk of bias was evaluated using the Cochrane Risk of Bias 2 method.</p><p><strong>Results: </strong>A total of 9 articles were eventually included in the study selection. Results of the meta-analysis reveal a statistically significant effect of virtual reality in reducing intraoperative anxiety in adults undergoing oral surgery (SMD = -0.26, 95% CI: (-0.48, -0.03), P < .05). Statistically significant effect in reducing intraoperative pain in adult oral surgery (SMD= -0.67, 95% CI: (-1.08, -0.26), P < .01).</p><p><strong>Conclusions: </strong>This meta-analysis confirms the value of virtual reality in terms of oral surgery by distracting adult patients from intraoperative anxiety and pain. However, more high-quality, multicenter, and large-sample randomized controlled trials are needed to further assess its clinical value in the future.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1016/j.oooo.2025.10.007
Andreas Sakkas, Thomas Lins, Majeed Rana, Mario Scheurer, Marcel Ebeling, Alexander Schramm, Frank Wilde, Matthias Tisch, Alisa Schramm, Guido Mühlmeier
Objectives: Odontogenic maxillary sinusitis remains a clinical challenge with incompletely understood recurrence patterns. This study aimed to determine the incidence of recurrence and identify associated risk factors following interdisciplinary surgical treatment involving oral and maxillofacial surgery and otorhinolaryngology.
Study design: A retrospective cohort of 203 patients treated for OMS over a 10-year period was analyzed. Data included demographic, clinical, radiological, and procedural variables. The primary outcome was OMS recurrence within 12 months after initial surgery. Univariable and multivariable analyses assessed associations between recurrence and defined risk factors.
Results: Among 203 patients (mean age 53.7 ± 18.4 years), the most common etiology was odontogenic cysts (44.3%). OMS recurrence occurred in 15.7% (n = 32) of cases. No significant association was found between recurrence and patient-specific factors (age, smoking, antiresorptive therapy, chemotherapy, sinusitis symptoms), anatomical variables (nasal septum deviation, congested maxillary sinus natural ostium), or procedural aspects (surgical removal of the intraoral cause with or without simultaneous FESS, surgical access route, multilayer soft tissue closure) (P > .05).
Conclusions: Despite a moderate recurrence rate, no significant patient-specific, anatomical, or procedure-specific predictors of recurrence were identified. These findings emphasize the importance of individualized treatment planning and interdisciplinary management. Prospective studies are needed to validate risk stratification tools for recurrence prevention in high-risk OMS patients.
{"title":"Risk profile for recurrence after interdisciplinary treatment of odontogenic maxillary sinusitis: experience of a single centre.","authors":"Andreas Sakkas, Thomas Lins, Majeed Rana, Mario Scheurer, Marcel Ebeling, Alexander Schramm, Frank Wilde, Matthias Tisch, Alisa Schramm, Guido Mühlmeier","doi":"10.1016/j.oooo.2025.10.007","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.10.007","url":null,"abstract":"<p><strong>Objectives: </strong>Odontogenic maxillary sinusitis remains a clinical challenge with incompletely understood recurrence patterns. This study aimed to determine the incidence of recurrence and identify associated risk factors following interdisciplinary surgical treatment involving oral and maxillofacial surgery and otorhinolaryngology.</p><p><strong>Study design: </strong>A retrospective cohort of 203 patients treated for OMS over a 10-year period was analyzed. Data included demographic, clinical, radiological, and procedural variables. The primary outcome was OMS recurrence within 12 months after initial surgery. Univariable and multivariable analyses assessed associations between recurrence and defined risk factors.</p><p><strong>Results: </strong>Among 203 patients (mean age 53.7 ± 18.4 years), the most common etiology was odontogenic cysts (44.3%). OMS recurrence occurred in 15.7% (n = 32) of cases. No significant association was found between recurrence and patient-specific factors (age, smoking, antiresorptive therapy, chemotherapy, sinusitis symptoms), anatomical variables (nasal septum deviation, congested maxillary sinus natural ostium), or procedural aspects (surgical removal of the intraoral cause with or without simultaneous FESS, surgical access route, multilayer soft tissue closure) (P > .05).</p><p><strong>Conclusions: </strong>Despite a moderate recurrence rate, no significant patient-specific, anatomical, or procedure-specific predictors of recurrence were identified. These findings emphasize the importance of individualized treatment planning and interdisciplinary management. Prospective studies are needed to validate risk stratification tools for recurrence prevention in high-risk OMS patients.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1016/j.oooo.2025.10.005
Gaye Bölükbaşı, Samed Gümüş, Maryam Sabour-Takanlou, Leila Sabour-Takanlou, Yavuz Öztürk, Aslı Tetik Vardarlı, İsa Kaya, Betul İlhan, Barış Oğuz Gürses, Ali Veral, Hayal Boyacıoğlu, Pelin Güneri
Objective: This study aimed to design and validate a magnetic levitation (ML) system for distinguishing benign, dysplastic, and malignant oral epithelial cells based on density measurements, using both tissue and brush biopsy samples.
Study design: A three-phase experimental study was conducted: (1) ML system calibration using microspheres and yeast cells of known density, (2) in vitro testing with OSCC and normal human oral keratinocyte cell lines, and (3) ex vivo validation using 59 patient-derived cell samples from brush and tissue biopsies, collected at Ege University. Density measurements were evaluated using descriptive statistics, ANOVA with Tukey's tests, regression analysis, and Pearson correlations. A Gaussian mixture model was applied to estimate epithelial components in tissue samples.
Results: From 3445 individual cells (2045 tissue, 1400 brush), OSCC cells showed significantly higher densities than benign and dysplastic cells (P < .05). Tissue-derived samples demonstrated clearer separation, but brush biopsy samples also distinguished OSCC from other categories. Correlations with disease status were positive for both sample types (brush r = 0.289; tissue r = 0.169), improving after Gaussian adjustment in tissue samples (r = 0.254).
Conclusion: This proof-of-concept study demonstrates that ML can differentiate benign and malignant oral epithelial cells, with brush biopsy results comparable to tissue biopsy findings. While not a replacement for histopathology, ML may offer a rapid, noninvasive adjunct for early OSCC assessment. Larger, clinically oriented studies are needed to establish its diagnostic thresholds and practical applicability.
{"title":"Magnetic levitation-based density profiling for ex vivo differentiation of oral squamous cell carcinoma, oral epithelial dysplasia, and benign oral lesions.","authors":"Gaye Bölükbaşı, Samed Gümüş, Maryam Sabour-Takanlou, Leila Sabour-Takanlou, Yavuz Öztürk, Aslı Tetik Vardarlı, İsa Kaya, Betul İlhan, Barış Oğuz Gürses, Ali Veral, Hayal Boyacıoğlu, Pelin Güneri","doi":"10.1016/j.oooo.2025.10.005","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.10.005","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to design and validate a magnetic levitation (ML) system for distinguishing benign, dysplastic, and malignant oral epithelial cells based on density measurements, using both tissue and brush biopsy samples.</p><p><strong>Study design: </strong>A three-phase experimental study was conducted: (1) ML system calibration using microspheres and yeast cells of known density, (2) in vitro testing with OSCC and normal human oral keratinocyte cell lines, and (3) ex vivo validation using 59 patient-derived cell samples from brush and tissue biopsies, collected at Ege University. Density measurements were evaluated using descriptive statistics, ANOVA with Tukey's tests, regression analysis, and Pearson correlations. A Gaussian mixture model was applied to estimate epithelial components in tissue samples.</p><p><strong>Results: </strong>From 3445 individual cells (2045 tissue, 1400 brush), OSCC cells showed significantly higher densities than benign and dysplastic cells (P < .05). Tissue-derived samples demonstrated clearer separation, but brush biopsy samples also distinguished OSCC from other categories. Correlations with disease status were positive for both sample types (brush r = 0.289; tissue r = 0.169), improving after Gaussian adjustment in tissue samples (r = 0.254).</p><p><strong>Conclusion: </strong>This proof-of-concept study demonstrates that ML can differentiate benign and malignant oral epithelial cells, with brush biopsy results comparable to tissue biopsy findings. While not a replacement for histopathology, ML may offer a rapid, noninvasive adjunct for early OSCC assessment. Larger, clinically oriented studies are needed to establish its diagnostic thresholds and practical applicability.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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