Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

{"title":"Management and prevalence of cone beam computed tomography (CBCT) findings generating external referrals","authors":"Dr. Sharmin Kadkhodayan ,&nbsp;Dr. Fabiana Almeida ,&nbsp;Dr. Hollis Lai ,&nbsp;Dr. Camila Pacheco-Pereira","doi":"10.1016/j.oooo.2024.11.007","DOIUrl":"10.1016/j.oooo.2024.11.007","url":null,"abstract":"<div><h3>Objective</h3><div>A debate regarding the responsibility of reporting all cone beam computed tomography (CBCT) findings exists, including the incidental findings (IFs) outside the region of interest. The possibility of missing a relevant diagnosis needing further investigation needs emphasis. Hence, our study aims to report the most prevalent IF with their management protocol to guide the dental professional in the decision-making and referral processes.</div></div><div><h3>Study Design</h3><div>Records of patients referred to the Advanced Imaging Centre-School of Dentistry were retrospectively reviewed. CBCT interpretive reports completed by Oral and Maxillofacial Radiologists were analyzed (N = 1260). The radiographic findings were divided into 8 zones on the basis of on their location: (1) airway, (2) temporomandibular joints, (3) cervical vertebrae, (4) bone lesions, (5) teeth, (6) soft-tissue calcifications, (7) paranasal sinuses, and (8) other. Descriptive statistics were used for demographic characteristics and locations of the radiographic finding. Inferential analyses were performed. The frequency and prevalence were determined for each specific finding requiring further investigation using quantitative analysis.</div></div><div><h3>Results</h3><div>A review of radiographic reports (N = 1260) showed a total of 501 scans with Ifs, which represents 39.7% of the total sample analyzed. The most prevalent radiographic findings outside the areas of interest were found in the cervical vertebrae (18%), followed by the sinuses (15%), temporomandibular joint (8%), jaw lesions (7%), airway (5%), teeth (5%), soft tissue calcifications (5%), and other (1%).</div></div><div><h3>Conclusions</h3><div>The most prevalent findings requiring referral were carotid atheroma (2.7%), osteoarthritis of cervical vertebrae (0.97%), jaw lesions (0.86%), adenoid hypertrophy (0.86%), and paranasal sinus pathology (0.73%). These entities were further explored, and guidelines were reported to help the dentists in the identification, decision making and referral processes. The management protocol proposed by our study should be used as a guideline for external referrals and follow-ups.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e69"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual stylocarotid artery syndrome—a vascular variant of Eagle syndrome","authors":"Dr. Bader Albalkhi ,&nbsp;Dr. Anita Gohel","doi":"10.1016/j.oooo.2024.11.046","DOIUrl":"10.1016/j.oooo.2024.11.046","url":null,"abstract":"<div><h3>Clinical Presentation</h3><div>Case 1: A 57-year-old female patient presented with a chief complaint of left-sided pain in her throat, especially upon yawning, bilateral deep pain at the left mandibular angle, odynophagia, and difficulty rotating head. There was no history of trauma. Panoramic radiograph demonstrated pronounced left stylohyoid ligament ossifications. Her symptoms did not resolve even after removal of the ossified left stylohyoid ligament. Multidetector computed tomography imaging revealed constriction of the left internal carotid artery (ICA) between the left styloid process and transverse process of C1.</div><div>Case 2: A 68-year old female patient presented with a chief complain of earaches, neck pain, and headaches on the left side. The patient also complained of pain in posterior and superior portion of the left side of her head with tenderness near the left occipital nerve. Cone beam computed tomography examination revealed extensive bilateral ossified stylohyoid ligament with narrow space between the styloid process and the transverse process of C-1 on the left side.</div></div><div><h3>Differential Diagnosis</h3><div>The clinical presentation and radiographic findings were consistent with stylocarotid artery syndrome as the radiographic diagnosis.</div></div><div><h3>Diagnosis and Management</h3><div>The treatment options include anticoagulation, thrombectomy, or surgical removal of the prominent styloid process. Bone reshaping of C1 is also advised treatment in some cases for preservation of the styloid muscles and ligaments.</div></div><div><h3>Conclusion</h3><div>The internal carotid artery compression by anomalous anatomical structures is rare. However, this can lead to the development of neurovascular complications related to mechanical impingement of the ICA. In both our cases the impingement of the ICA was related to decreased space between the styloid process and C1. These decreased distances between the stylohyoid-C1 complex may result in mechanical injury and predispose to carotid artery dissection, pseudoaneurysm and thromboembolism (carotid artery entrapment syndrome). Oral and maxillofacial radiologists should routinely evaluate styloid/C1 transverse process juxtaposition avoid these complications.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e85"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoblastoma or osteosarcoma: a diagnostic dilemma","authors":"Dr. Srinitha Singanamala ,&nbsp;Dr. Todd Kovach ,&nbsp;Dr. Lisa Yi- Shing Cheng ,&nbsp;Dr. Hui Liang","doi":"10.1016/j.oooo.2024.11.024","DOIUrl":"10.1016/j.oooo.2024.11.024","url":null,"abstract":"<div><h3>Clinical presentation</h3><div>A 14-year-old male patient exhibited painless swelling in the right mandibular canine-premolar region, persisting for 3 months. Upon examination, a firm, nontender mass was observed in right mandible with mobile teeth. Cone beam computed tomography revealed a partially well-defined mixed radiopaque-radiolucent lesion extending from the distal aspect of #27 root to distal aspect of #29 root. The lesion involved the buccal and lingual cortices, extending from alveolar crest to the middle to apical thirds of the roots in the involved teeth. Divergent premolar roots, mild widened apical periodontal ligament (PDL) space of #27 and #28, disruption of the lingual cortical plate, prominent expansion on lingual mandible were also noted. Crestal bone growth at the coronal thirds lingually was evident, whereas the mental foramen appeared unaffected.</div></div><div><h3>Differential Diagnosis</h3><div>Clinically, provisional diagnosis of cemento-ossifying fibroma was considered. Radiographic differential diagnosis included cemento-ossifying fibroma, osteoblastoma, or osteosarcoma.</div></div><div><h3>Diagnosis and Management</h3><div>Histologic examination revealed atypical pleomorphic osteoblasts with abundant osteoid formation in a well-vascularized fibrous stroma. The lesional tissue appeared to fuse to or invade the normal bony trabeculae and there was no fibrous capsule separating the abnormal osteoblastic activity from the adjacent normal bone. A diagnosis of well-differentiated osteoblastic osteosarcoma was made based on histological features and radiographic findings, particularly widening of PDL space. The case was sent to MD Anderson for second opinion and was diagnosed as “atypical osteoblastic lesion, most consistent with osteoblastoma.” The patient was treated by right marginal mandibulectomy.</div></div><div><h3>Conclusion</h3><div>The observed characteristics of crestal bone growth, external root resorption, and widened PDL space in this case were indicative of a malignant process. Distinguishing between osteoblastoma and osteosarcoma can occasionally pose challenges for pathologists, highlighting the significance of radiographic findings and cone beam computed tomography imaging in assisting histological interpretation and establishing a definitive diagnosis.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e76"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive (epithelioid) osteoblastoma camouflaged by pain associated with erupting third molars—case report and literature review","authors":"Dr. Yashaswini Jagadeesh ,&nbsp;Dr. Todd Kovach ,&nbsp;Dr. Lisa Yi- Shing Cheng ,&nbsp;Dr. Hui Liang","doi":"10.1016/j.oooo.2024.11.022","DOIUrl":"10.1016/j.oooo.2024.11.022","url":null,"abstract":"<div><h3>Clinical Presentation</h3><div>A 16-year-old patient was referred for extraction of third molars and supernumerary tooth distal of #17, as he had been experiencing pain in the left mandible. The pain persisted for more than 2 weeks after extraction of #17. Although the extraction site demonstrated good initial healing, there was evidence of significant bony expansion lingually with mobile #18 and 19. This had shown significant progression since the preoperative examination. A panoramic study showed resorption of distal root #19. Cone beam computed tomography scan was performed and showed a large, expansile, ill-defined, mixed density but predominantly radiolucent lesion. In addition, disruption of the lingual cortex and superior border of inferior alveolar canal was observed with no signs of paresthesia clinically.</div></div><div><h3>Differential Diagnosis</h3><div>Expansile bone tumors of jaw with resorption would include cemento-ossifying fibroma, osteoblastoma and osteosarcoma.</div></div><div><h3>Diagnosis and Management</h3><div>Histopathologic examination revealed an epithelioid neoplasm consisting of clusters of round epithelioid cells surrounding blue lace-like bony trabeculae (osteoid). Cytomorphology was bland and mitoses were occasionally seen. A diagnosis of aggressive (epithelioid) osteoblastoma was rendered. Management involved en-bloc resection with wide margins as epithelioid osteoblastoma has a high recurrence rate of almost 50%.</div></div><div><h3>Conclusions</h3><div>Aggressive (epithelioid) osteoblastoma, a rare histological subtype of osteoblastoma, shows a tendency for local invasion and high recurrence rate. Few cases have been reported in the jaws, with the mandible more commonly affected than the maxilla. The presence of pain from the emerging third molar and subtle clinical and radiologic evidence before extraction were the culprits which the lesion was not initially detected. Otherwise, the intense clinical expansion following extraction, location, and radiographic characteristics of this case appear to be consistent with the cases reported in the literature. Closely follow-up is recommended to monitor possible recurrence.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e75"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and type of exaggerated external occipital protuberances in a wide-age population","authors":"Mr. Brandon Crowther ,&nbsp;Dr. Anita Gohel ,&nbsp;Dr. Jennie Caldwell","doi":"10.1016/j.oooo.2024.11.071","DOIUrl":"10.1016/j.oooo.2024.11.071","url":null,"abstract":"<div><h3>Objective</h3><div>Exaggerated external occipital protuberances, also known as occipital spurs or chignon hooks, are a commonly found anatomical variant in large field-of-view cone beam computed tomography (CBCT) images and have been shown to correlate with clinical neck pain. Occipital spurs present in 3 types: type I, smooth; type II, sharp; type III, hooked (curved). A recent study by Shahar et al. characterizes the incidence of this finding in the 18-86 age group, but limited data exist to describe the type of spur found based on sex in wide-age populations. This study aims to provide data on the incidence of occipital spurs in a wide-age population (9-54 years) characterized by sex and type of spur present.</div></div><div><h3>Study Design</h3><div>In total, 100 large field-of-view CBCT scans taken between February 2021 and January 2023 were assessed by an oral radiology resident and a calibrated dental student. The image was properly oriented and the presence of an occipital spur, spur type, patient age, and sex were recorded. From this, incidence based on sex and type of spur present was obtained.</div></div><div><h3>Results</h3><div>The data revealed that 76% of male patients and 67% of female patients in the sample had occipital spurs present. Type I spurs were present in 38.5% of females and 21.9% of males. Type II spurs were present in 46% of females and 62.5% of males. Type III spurs were found in 15.3% of females and 15.6% of males.</div></div><div><h3>Conclusions</h3><div>Occipital spurs present similarly between sexes, with males showing a predilection for type II spurs. Females display a similar predilection for both type I and type II spurs, and both sexes display similar incidence of type III spurs. Occipital spurs are a frequent variant that can be observed in CBCT studies taken for orthodontic planning, which is important to note, as it may have clinical implications.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Pages e94-e95"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of pleomorphic adenoma","authors":"Dr. Priyanka Agarwal ,&nbsp;Dr. Adriana Creanga ,&nbsp;Dr. Steven Singer","doi":"10.1016/j.oooo.2024.11.038","DOIUrl":"10.1016/j.oooo.2024.11.038","url":null,"abstract":"<div><div>Pleomorphic adenoma (PA) is a benign salivary gland neoplasm. It represents 45% to 74% of all salivary gland tumors and is associated with recurrence, malignant transformation, and metastasis. The risk of malignant transformation in PA increases from around 1.6% in tumors with less than 5 years of evolution to 9.5% for those presenting for more than 15 years. Malignancies arising in PA encompass 3 entities: (1) carcinoma ex-pleomorphic adenoma (CXPA), (2) carcinosarcoma, and (3) metastasizing benign pleomorphic adenoma. CXPA is a rare, aggressive, poorly understood malignancy that usually develops in a primary or recurrent PA.</div><div><strong>Case Description:</strong> A 65-year-old female patient reported a chief complaint of pain and swelling below the lower jaw and around her ears, for 2 years. The patient had a history of swelling at the same site 20 years prior, which was operated on 2 years ago. On clinical examination, the swelling was present on the mandibular left posterior region, extending anteriorly from the lobule of the ear, and posteriorly along the length of the neck down to the supraclavicular notch. Upon palpation, the mass was soft to firm, lobulated, and nodular.</div><div><strong>Radiographic Imaging.</strong> Computed tomographic imaging of soft tissue windows reveals a well-defined predominantly cystic mass. The chest radiographs demonstrate a cannonball appearance. Multiple variable radiolucencies, seen in both lungs, are suggestive of metastasis.</div><div><strong>Differential Diagnosis.</strong> On the basis of clinical and radiographic imaging, the differential diagnosis includes metastasis, Wegner's granulomatosis, and CXPA.</div><div><strong>Diagnosis and Management:</strong> Fine needle aspiration was done, and was reported as CXPA. An excisional biopsy was then taken, and tissue was sent for histopathology, confirming the fine-needle aspiration diagnosis.</div><div><strong>Clinical Implication.</strong> Understanding the underlining complications of pleomorphic adenoma makes us better equipped to render an earlier diagnosis and optimal treatment to the patient.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Pages e81-e82"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal patient-reported oral health outcomes among patients who have received allogeneic hematopoietic stem cell transplantation","authors":"Leah Leinbach ,&nbsp;Shahdokht Boroumand ,&nbsp;Joe Nguyen ,&nbsp;Jacqueline Mays","doi":"10.1016/j.oooo.2024.10.093","DOIUrl":"10.1016/j.oooo.2024.10.093","url":null,"abstract":"<div><h3>Objective</h3><div>To describe longitudinal patient-reported oral health outcomes in the domains of oral health-related quality-of-life (OHRQoL) and performance status through 24 months postallogeneic hematopoietic stem cell transplantation (allo-HSCT).</div></div><div><h3>Methods</h3><div>This is an interim analysis using data from an ongoing National Institutes of Health natural history study (NCT03602599) of patients 18 years or older who have undergone allo-HSCT. Data were captured using the Oral Health Impact Profile-14 (OHIP-14) and standard performance status questionnaires. Means and standard deviations were calculated for continuous variables and frequencies and percentages for categorical variables. Lower OHIP-14 scores indicated better OHRQoL. All analyses were conducted using SAS 9.4.</div></div><div><h3>Results</h3><div>In total, 117 participants were screened for inclusion, 8 were not transplanted, and 2 withdrew consent, yielding a final study population of 107 participants at baseline, 95 at 3 months, 79 at 6 months, 72 at 12 months, 59 at 18 months, and 55 at 24 months after allo-HSCT. A total of 50.5% received a transplant for cancer, 49.5% for other reasons. 13% developed chronic graft-versus-host (cGVHD) during the study period. At time of transplant, the mean OHIP score was 3.7 (± 5.7), less than 10% of patients reported moderate-to-severe pain or dryness within the last month, 9% reported reduced oral health status compared with the previous month, and nearly all were on a full diet. Moderate-to-severe dry mouth was worst after 3 months (19% of patients), moderate-to-severe pain and dietary changes at 6 months (14% and nearly 20% of patients respectively), mean OHIP scores were worst at 12 months (4.8 ± 7.3). By 24 months, the mean OHIP was 4.1 (± 7.1), moderate-to-severe pain was reported by 9% of patients, moderate-to-severe dry mouth by 7% of patients, and nearly all were at a full diet. In cGVHD, mean OHIP was 16.8 (± 12.2), 50% reported moderate-to-severe pain, 17% reported moderate-to-severe dry mouth, 17% reported decline in oral health status, 60% were at a full diet at 24 months.</div></div><div><h3>Conclusions</h3><div>Data show that OHRQoL and performance status decline after allo-HSCT, with certain issues persisting through 24 months, particularly in cGVHD. Continued consideration for long-term, specialized oral health care among this patient population is indicated. Funding: NIH Intramural Research Program</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Page e49"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-dependent modulation of a B-cell protein signature by ianalumab in patients with Sjögren disease","authors":"Athena S. Papas ,&nbsp;Andrea Grioni ,&nbsp;Benjamin A. Fisher ,&nbsp;Stephanie Finzel ,&nbsp;Alexandre Avrameas ,&nbsp;Danny Tuckwell ,&nbsp;Jonas Zierer ,&nbsp;Celine Rauld ,&nbsp;Valeria De Luca ,&nbsp;Enrico Ferrero ,&nbsp;Andre Nogueira da Costa ,&nbsp;Rainer Hillenbrand ,&nbsp;Isabelle Isnardi ,&nbsp;Wolfgang Hueber","doi":"10.1016/j.oooo.2024.10.097","DOIUrl":"10.1016/j.oooo.2024.10.097","url":null,"abstract":"<div><h3>Objective</h3><div>Ianalumab, an afuscosylated monoclonal antibody, depletes B cells and blocks survival signals mediated by the B-cell activating factor receptor (BAFFR). Sjögren disease (SjD) is an autoimmune disorder with exocrine glandular and extraglandular manifestations, elevated BAFF, and autoantibodies to nuclear antigens. A phase 2b dose-finding trial of ianalumab (NCT02962895) in 190 patients with active SjD met its primary endpoint; 300 mg was clinically efficacious and improved whole salivary flow. Here, we explored changes in autoantibody and proteomic signatures with ianalumab treatment to characterize biomarkers associated with SjD disease activity.</div></div><div><h3>Methods</h3><div>Patients with active SjD (N = 190) were randomized (1:1:1:1) to receive placebo or ianalumab (5/50/300 mg). Serum samples collected at baseline and week 24 were used for protein profiling and delineation of interferon protein signatures using the SomaScan(R) v4.1 platform. Autoantibodies and BAFF levels were assessed by Luminex-based enzyme-linked immunoassay assays. A linear mixed-effect model was used to identify longitudinal changes in protein concentration at week 24 versus baseline. Results were visualized using heatmaps and hierarchical clustering.</div></div><div><h3>Results</h3><div>At baseline, cluster analysis did not reveal significant correlations between European League Against Rheumatism Sjögren's Syndrome Disease Activity Index scores (including subdomains) and levels of autoantibodies or proteins of interest. Ianalumab led to marked changes in autoantibody and serum protein levels. The 300-mg dose showed increased numbers of significantly modulated serum proteins (42) with more pronounced expression modulation versus the 5-mg (9) and 50-mg (20) dose groups. Several B-cell surface proteins were consistently downregulated by ianalumab, including FcRL4, plausibly involved in the pathogenicity of SjD. The 50-mg and 300-mg doses induced downregulation of additional proteins: B-cell maturation antigen, specifically expressed by antibody-producing cells, or the chemokines CXCL13 and CCL21, associated with immune infiltration of glandular tissues. A trend for downregulation of interferon protein signatures was seen with 50-mg and 300-mg doses.</div></div><div><h3>Conclusions</h3><div>No differential proteomic signatures related to baseline disease activity were identified. The dose response in clinical efficacy of ianalumab in patients with SjD observed in the phase 2b trial is also reflected at the protein level, with increased depth and breadth of proteomic changes by week 24, correlating with increasing dose.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Pages e50-e51"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of biological information in the diagnostic process: a glance into the future of dentistry","authors":"Katherine France DMD, MBE ,&nbsp;Craig S. Miller DMD, MS","doi":"10.1016/j.oooo.2024.09.009","DOIUrl":"10.1016/j.oooo.2024.09.009","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Pages 131-133"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Society Page","authors":"","doi":"10.1016/S2212-4403(24)00913-1","DOIUrl":"10.1016/S2212-4403(24)00913-1","url":null,"abstract":"","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 2","pages":"Page A5"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}