Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

英文中文

Deep learning for automated alveolar cleft segmentation and bone graft volume estimation in cone-beam computed tomography imaging: a multicenter study 深度学习在锥形束计算机断层成像中的自动牙槽裂隙分割和骨移植体积估计：一项多中心研究。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-12 DOI: 10.1016/j.oooo.2025.10.020

António Vicente DDS, Msc , Kuo Feng Hung DDS, MDS, PhD , Zineng Xu Msc , Jiegang Yang DDS, PhD , Jian Li MD, PhD , Anna-Paulina Wiedel DDS, PhD , Magnus Becker MD, PhD , Susanne Brogårdh-Roth DDS, PhD , Peng Ding PhD , Kristina Hellén-Halme DDS, PhD , Xie-Qi Shi DDS, PhD

Objective

To train and validate a deep learning-based diagnostic tool capable of accurately segmenting the alveolar cleft region and automatically estimating the required bone graft volume using cone-beam computed tomography (CBCT) imaging.

Study Design

Eighty-eight CBCT scans from patients with nonsyndromic unilateral clefts were divided into training (n = 45), validation (n = 10), and test (n = 33) sets. Two annotators performed manual segmentations, and the intersection of these served as the ground truth for training three-dimensional (3D) U-Net models. The dice similarity coefficient (DSC) was calculated to validate the tool by comparing manual and automated segmentations. Three observers evaluated the resulting deep learning model using 33 CBCT scans and performing subjective assessments in terms of shape and size.

Results

The dice similarity coefficient (DSC) between the two annotators was 0.66, and between the automated and manual segmentations, 0.78. The observers considered the automated segmentations acceptable in 82%-94% of the cases. The deep learning-based tool took approximately second seconds to perform an automated segmentation, while manual segmentation by the annotators required 14 and 6.5 minutes.

Conclusion

The deep learning-based tool that was developed in the present study can accurately perform automated segmentations of unilateral alveolar clefts and estimate the required bone graft volume.

目的：训练并验证一种基于深度学习的诊断工具，该工具能够使用锥形束计算机断层扫描（CBCT）成像准确分割牙槽骨裂区域并自动估计所需的骨移植体积。研究设计：88例非综合征性单侧唇裂患者的CBCT扫描被分为训练组（n = 45）、验证组（n = 10）和测试组（n = 33）。两个注释器执行手动分割，这些分割的交集作为训练三维（3D） U-Net模型的基础真理。计算骰子相似系数（DSC），通过比较手动和自动分割来验证工具。三名观察员使用33次CBCT扫描评估了由此产生的深度学习模型，并在形状和大小方面进行了主观评估。结果：两种标注器之间的骰子相似系数（DSC）为0.66，自动和手动分割之间的骰子相似系数为0.78。观察员认为自动分割在82%-94%的情况下是可接受的。基于深度学习的工具大约需要2秒来执行自动分割，而注释器的手动分割需要14分钟和6.5分钟。结论：本研究开发的基于深度学习的工具可以准确地进行单侧牙槽骨裂的自动分割并估计所需的骨移植体积。

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引用次数: 0

Three-dimensional finite element assessment of grid-type plate in 2 different designs of sagittal split osteotomy of the mandibular ramus. 网格型钢板在2种不同设计的下颌支矢状劈裂截骨术中的三维有限元评价。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-12 DOI: 10.1016/j.oooo.2025.11.002

Eduardo Santana Jacob, Luma Caroline Vendrame, Milena Gomes Melo Leite, Marcelo Silva Monnazzi, Eduardo Hochuli-Vieira

Objective: To evaluate stress distribution in the grid plate-screw system and cortical bone in 2 sagittal split ramus osteotomy (SSRO) designs, with linear advancements of 5.0 mm and 7.0 mm, using finite element analysis.

Study design: A three-dimensional mandibular model was reconstructed from computed tomography (CT) scan and processed into finite element meshes. Grid plates with 4 monocortical screws were virtually positioned in the tension zone. Two osteotomy designs were tested: conventional Epker technique (Group I) and short split technique (Group II). Each design underwent advancements of 5.0 mm (a) and 7.0 mm (b). Masticatory muscle forces and occlusal loads were applied, and stress distribution in plates, screws, and cortical bone were analyzed using the Von Mises criterion.

Results: Greater mandibular advancement produced higher stresses in bone and fixation components. Group IIa demonstrated the lowest stress values, whereas Group IIb showed the highest peaks, particularly on plates and screws. Group I exhibited intermediate values with less disparity between 5.0-mm and 7.0-mm movements. Stress concentration increased proportionally with advancement.

Conclusion: The short osteotomy design provided favorable stress distribution for 5.0-mm advancements but reached critical stress levels at 7.0 mm, suggesting limited reliability for larger movements. Grid plates appear safe for smaller advancements in sagittal split ramus osteotomy (SSRO).

目的：应用有限元分析方法，评价2矢状面劈裂支截骨术（SSRO）设计中线性推进5.0 mm和7.0 mm的网格钢板-螺钉系统和皮质骨的应力分布。研究设计：通过计算机断层扫描（CT）重建三维下颌模型，并将其处理成有限元网格。带4个单皮质螺钉的网格板实际上位于张力区。测试了两种截骨设计：常规Epker技术（I组）和短裂技术（II组）。每个设计都经历了5.0 mm (a)和7.0 mm (b)的推进。施加咀嚼肌力和咬合负荷，使用Von Mises标准分析板、螺钉和皮质骨的应力分布。结果：下颌前移越大，骨和固定构件的应力越大。IIa组的应力值最低，而IIb组的应力值最高，尤其是在钢板和螺钉上。组I表现为中间值，在5.0 mm和7.0 mm运动之间差异较小。应力集中随推进成比例增大。结论：短截骨设计为5.0 mm的移动提供了良好的应力分布，但在7.0 mm时达到了临界应力水平，这表明对于更大的移动可靠性有限。栅格钢板对于矢状分支截骨术（SSRO）的小进展是安全的。

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引用次数: 0

Radiotherapy-induced pemphigus vulgaris: a challenging case of extensive mucocutaneous ulcerations and literature review. 放疗引起的寻常性天疱疮：广泛的皮肤粘膜溃疡的一个具有挑战性的病例和文献复习。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-12 DOI: 10.1016/j.oooo.2025.11.004

Brenda Corrêa Santos, Daniel Lobato Ferreira Ferraz, Mariana Hamra Eleuterio, Caio Marcelo Jorge, Rachel Martins Marinho, Márcio Ajudarte Lopes

Objective: To report a challenging case of radiotherapy-induced pemphigus vulgaris presenting as extensive mucocutaneous ulcerations and to highlight diagnostic and therapeutic considerations.

Study design: A 59-year-old man with a history of tobacco and alcohol use presented with a persistent ulcer on the floor of the mouth. Incisional biopsy confirmed squamous cell carcinoma. The patient underwent surgical resection with cervical lymph node dissection, followed by adjuvant radiotherapy (33 fractions, cumulative dose of 6600 cGy) and cisplatin chemotherapy. Approximately one month after completion of radiotherapy, he developed painful erosive lesions with thick crusting involving the lips and malar region, which rapidly extended to the chin, neck, and back, with extensive epithelial loss. Skin biopsy was performed for diagnostic clarification.

Results: Histopathological analysis confirmed the diagnosis of pemphigus vulgaris. Paraneoplastic pemphigus was excluded based on imaging studies showing no evidence of active malignancy. The patient required 40 days of hospitalization with nutritional support via a nasoenteric tube. Treatment with high-dose systemic prednisone resulted in progressive clinical improvement and lesion healing. At 8 months of follow-up, the patient remained disease-free.

Conclusion: Pemphigus vulgaris may represent a rare but severe complication following radiotherapy. Early recognition and prompt immunosuppressive treatment are essential to reduce morbidity and improve patient outcomes.

目的：报告一例具有挑战性的放射治疗性寻常型天疱疮，表现为广泛的皮肤粘膜溃疡，并强调诊断和治疗注意事项。研究设计：一名有烟酒史的59岁男性，口腔底部出现持续性溃疡。切口活检证实为鳞状细胞癌。患者行手术切除颈部淋巴结清扫，辅助放疗（33次，累计剂量6600 cGy）及顺铂化疗。放疗完成约1个月后，患者出现疼痛的糜烂性病变，伴厚痂，累及唇部和颧区，并迅速扩展至下巴、颈部和背部，伴广泛上皮丢失。进行皮肤活检以明确诊断。结果：组织病理学分析证实了寻常型天疱疮的诊断。基于影像学研究显示没有活动性恶性肿瘤的证据，排除了副肿瘤性天疱疮。患者需要住院40天，并通过鼻肠管给予营养支持。大剂量全身性强的松治疗导致临床进展改善和病变愈合。随访8个月，患者无疾病。结论：寻常型天疱疮是一种罕见但严重的放射治疗并发症。早期识别和及时的免疫抑制治疗对于降低发病率和改善患者预后至关重要。

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引用次数: 0

Ozone therapy for medication-related osteonecrosis of the jaw: a scoping review. 臭氧治疗颌骨药物相关性骨坏死：范围综述。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-12 DOI: 10.1016/j.oooo.2025.11.005

Miguel Ruiz Rincón, Jorge Cortés-Bretón Brinkmann, Marko Granić, Luis Miguel Sáez-Alcaide, Luis Sánchez-Labrador, Carmen López-Carriches, Cristina Madrigal Martínez-Pereda

Objectives: To review the existing literature on the use of ozone therapy in the management of medication-related osteonecrosis of the jaw (MRONJ) lesions.

Study design: An electronic search was conducted in Medline/PubMed, Web of Science, Cochrane Library, Scopus, and OpenGray databases. The study protocol was registered in the Open Science Framework (OSF) (DOI: 10.17605/OSF.IO/FHAEM). Data extracted from selected works included authorship, year of publication, study design, number of patients and MRONJ lesions, ozone therapy type and protocol, device used, additional treatments, cause of osteonecrosis, mean age, follow-up period, lesion and patient healing success rates, and complications reported.

Results: The initial search identified 194 articles, of which 14 met the inclusion criteria. These studies included 191 patients with 197 MRONJ lesions. Ozone therapy protocols and additional treatments varied widely across studies. Complete mucosal healing and resolution of necrotic lesions without symptoms were observed in 137 of 191 patients (71.73%) and 143 of 197 lesions (72.59%).

Conclusions: Ozone therapy would appear a promising adjunctive treatment for MRONJ, due to its antimicrobial, anti-inflammatory, and tissue-regenerative effects. Nevertheless, further well-designed, large-scale clinical trials with standardized protocols and long-term follow-up periods are needed to confirm its efficacy and define its role in clinical practice.

目的：综述臭氧治疗药物相关性颌骨骨坏死（MRONJ）病变的文献。研究设计：在Medline/PubMed、Web of Science、Cochrane Library、Scopus和OpenGray数据库中进行电子检索。该研究方案已在开放科学框架（OSF）中注册（DOI: 10.17605/OSF. io /FHAEM）。从选定的文献中提取的数据包括作者、出版年份、研究设计、患者数量和MRONJ病变、臭氧治疗类型和方案、使用的设备、附加治疗、骨坏死原因、平均年龄、随访时间、病变和患者愈合成功率以及并发症报告。结果：初步检索到194篇文章，其中14篇符合纳入标准。这些研究包括191例患者197个MRONJ病变。臭氧治疗方案和其他治疗方法在不同的研究中差异很大。191例患者中有137例（71.73%）和143例（72.59%）的粘膜完全愈合和坏死灶无症状消退。结论：臭氧治疗具有抗菌、抗炎和组织再生的作用，有望成为MRONJ的辅助治疗方法。然而，需要进一步精心设计的、具有标准化方案的大规模临床试验和长期随访期，以确认其疗效并确定其在临床实践中的作用。

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引用次数: 0

Proposal for a tooth extraction protocol for patients taking direct oral anticoagulants: a clinical trial. 直接口服抗凝剂患者拔牙方案的建议：临床试验。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-12 DOI: 10.1016/j.oooo.2025.10.021

Elaine Massumi Higashi, Itamara Lucia Itagiba Neves, Francisco Carlos da Costa Darrieux, Marcela Alves Dos Santos Paul, Gustavo Luiz Alkmin Paiva, Vitor Takao Omori, Ricardo Simões Neves, Maurício Ibraim Scanavacca, Denise Tessariol Hachul

Objective: To evaluate the feasibility of a protocol in which direct oral anticoagulants (DOACs) are not discontinued prior to tooth extractions, compared with warfarin.

Study design: A prospective blind study was conducted on anticoagulated patients with atrial fibrillation undergoing tooth extraction. Patients were divided into three groups according to the anticoagulant pharmacokinetics: 20 patients on rivaroxaban once daily; 18 on dabigatran or apixaban twice daily, and 20 on warfarin (control group). Extractions were scheduled during the lowest DOACs plasma concentration: 14 hours after the last rivaroxaban dose; 8 hours after the last dabigatran/apixaban dose; and with INR values between 2.0 and 3.0 in the warfarin group. Patients returned 24 hours after tooth extraction for evaluation of bleeding.

Results: Fifty-eight patients were included in the study, in a total of 84 tooth extractions. No minor or major bleeding occurred in the rivaroxaban group. Two patients in the dabigatran/apixaban group (11.1%) and two in the control group (10%) presented minor bleeding. There was no statistically significant difference in bleeding rates among the groups (P = .324), and no major bleeding events were reported.

Conclusion: These preliminary results suggest that the protocol proposing non-discontinuing DOACs in extractions may be feasible in clinical practice.

目的：比较华法林和直接口服抗凝剂（DOACs）在拔牙前不停用的方案的可行性。研究设计：对抗凝心房颤动患者进行拔牙的前瞻性盲法研究。根据抗凝药代动力学将患者分为3组：20例患者使用利伐沙班，每日1次；18人服用达比加群或阿哌沙班每日两次，20人服用华法林（对照组）。在DOACs最低血浆浓度时进行提取：利伐沙班末次给药后14小时；最后一次给药达比加群/阿哌沙班后8小时；华法林组INR值在2.0 ~ 3.0之间。患者在拔牙后24小时返回评估出血情况。结果：58例患者纳入研究，共拔牙84例。利伐沙班组无大出血发生。达比加群/阿哌沙班组2例（11.1%）和对照组2例（10%）出现轻度出血。两组间出血率差异无统计学意义（P = .324），无大出血事件报告。结论：这些初步结果表明，在拔牙中提出不间断DOACs方案在临床实践中是可行的。

{"title":"Proposal for a tooth extraction protocol for patients taking direct oral anticoagulants: a clinical trial.","authors":"Elaine Massumi Higashi, Itamara Lucia Itagiba Neves, Francisco Carlos da Costa Darrieux, Marcela Alves Dos Santos Paul, Gustavo Luiz Alkmin Paiva, Vitor Takao Omori, Ricardo Simões Neves, Maurício Ibraim Scanavacca, Denise Tessariol Hachul","doi":"10.1016/j.oooo.2025.10.021","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.10.021","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the feasibility of a protocol in which direct oral anticoagulants (DOACs) are not discontinued prior to tooth extractions, compared with warfarin.</p><p><strong>Study design: </strong>A prospective blind study was conducted on anticoagulated patients with atrial fibrillation undergoing tooth extraction. Patients were divided into three groups according to the anticoagulant pharmacokinetics: 20 patients on rivaroxaban once daily; 18 on dabigatran or apixaban twice daily, and 20 on warfarin (control group). Extractions were scheduled during the lowest DOACs plasma concentration: 14 hours after the last rivaroxaban dose; 8 hours after the last dabigatran/apixaban dose; and with INR values between 2.0 and 3.0 in the warfarin group. Patients returned 24 hours after tooth extraction for evaluation of bleeding.</p><p><strong>Results: </strong>Fifty-eight patients were included in the study, in a total of 84 tooth extractions. No minor or major bleeding occurred in the rivaroxaban group. Two patients in the dabigatran/apixaban group (11.1%) and two in the control group (10%) presented minor bleeding. There was no statistically significant difference in bleeding rates among the groups (P = .324), and no major bleeding events were reported.</p><p><strong>Conclusion: </strong>These preliminary results suggest that the protocol proposing non-discontinuing DOACs in extractions may be feasible in clinical practice.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of clinical outcomes between DDWOR and TMJ-OA patients treated with arthrocentesis and injectable PRF: a 12-month follow-up study. DDWOR和TMJ-OA患者关节穿刺和注射PRF治疗的临床结果比较：一项12个月的随访研究。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-12 DOI: 10.1016/j.oooo.2025.11.003

Mehmet Zahit Baş, Tahsin Tepecik

Objective: To compare 12-month outcomes of single-session arthrocentesis with intra-articular injectable platelet-rich fibrin (i-PRF) in temporomandibular joint osteoarthritis (OA) vs disc displacement without reduction (DDWOR).

Study design: Single-center retrospective cohort of 89 consecutive patients (OA = 48, DDWOR = 41) treated by one surgeon.

Methods: Double-needle lavage (∼100 mL saline) followed by intra-articular i-PRF (∼1.5 mL). Primary outcomes were pain on function (0-100 visual analog scale) and maximum interincisal opening (mm) measured at baseline (T0) and 12 months (T1). Two-tailed tests (α = 0.05) and Cohen's d were used.

Results: Both groups improved significantly at T1 (P < .001). OA showed greater relative pain reduction (-66.4% vs -52.5%; d≈0.50), whereas DDWOR achieved larger functional gains (ΔMIO 5.34 vs 2.71 mm; +19.7% vs +8.8%; d≈0.77-0.84).

Conclusions: Arthrocentesis plus i-PRF yields clinically meaningful 12-month improvements in both conditions, with greater pain relief in OA and greater mouth-opening gains in DDWOR, supporting individualized, goal-oriented TMJ management.

目的：比较单次关节穿刺联合关节内注射富血小板纤维蛋白（i-PRF）治疗颞下颌关节骨性关节炎（OA）和椎间盘不复位移位（DDWOR）的12个月疗效。研究设计：由一名外科医生治疗的89例连续患者（OA = 48, DDWOR = 41）的单中心回顾性队列。方法：双针灌洗（~ 100 mL生理盐水），然后关节内注射i-PRF （~ 1.5 mL）。主要结果是功能疼痛（0-100视觉模拟量表）和基线（T0）和12个月（T1）测量的最大内脏开口（mm）。采用双尾检验（α = 0.05）和Cohen’s d。结果：两组在T1时均有显著改善（P < 0.001）。OA表现出更大的相对疼痛减轻（-66.4% vs -52.5%; d≈0.50），而DDWOR实现了更大的功能增益（ΔMIO 5.34 vs 2.71 mm; +19.7% vs +8.8%; d≈0.77-0.84）。结论：关节穿刺加i-PRF在这两种情况下均可获得临床意义上的12个月改善，OA患者疼痛缓解更大，DDWOR患者开口更大，支持个体化、目标导向的TMJ治疗。

{"title":"Comparison of clinical outcomes between DDWOR and TMJ-OA patients treated with arthrocentesis and injectable PRF: a 12-month follow-up study.","authors":"Mehmet Zahit Baş, Tahsin Tepecik","doi":"10.1016/j.oooo.2025.11.003","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.11.003","url":null,"abstract":"<p><strong>Objective: </strong>To compare 12-month outcomes of single-session arthrocentesis with intra-articular injectable platelet-rich fibrin (i-PRF) in temporomandibular joint osteoarthritis (OA) vs disc displacement without reduction (DDWOR).</p><p><strong>Study design: </strong>Single-center retrospective cohort of 89 consecutive patients (OA = 48, DDWOR = 41) treated by one surgeon.</p><p><strong>Methods: </strong>Double-needle lavage (∼100 mL saline) followed by intra-articular i-PRF (∼1.5 mL). Primary outcomes were pain on function (0-100 visual analog scale) and maximum interincisal opening (mm) measured at baseline (T0) and 12 months (T1). Two-tailed tests (α = 0.05) and Cohen's d were used.</p><p><strong>Results: </strong>Both groups improved significantly at T1 (P < .001). OA showed greater relative pain reduction (-66.4% vs -52.5%; d≈0.50), whereas DDWOR achieved larger functional gains (ΔMIO 5.34 vs 2.71 mm; +19.7% vs +8.8%; d≈0.77-0.84).</p><p><strong>Conclusions: </strong>Arthrocentesis plus i-PRF yields clinically meaningful 12-month improvements in both conditions, with greater pain relief in OA and greater mouth-opening gains in DDWOR, supporting individualized, goal-oriented TMJ management.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Society Page 社会页面

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-06 DOI: 10.1016/S2212-4403(25)01241-6

引用次数: 0

Information for Readers 读者资讯

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-06 DOI: 10.1016/S2212-4403(25)01242-8

引用次数: 0

Acknowledgement to Reviewers 2025 向审稿人致谢2025

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-06 DOI: 10.1016/j.oooo.2025.08.012

引用次数: 0

Reported mouth self-examination methods for oral cancer screening: a systematic review 已有报道的口腔癌筛查的口腔自检方法：系统综述。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-04 DOI: 10.1016/j.oooo.2025.10.014

Mariana Mayume Carvalho Kadooka DDS , Caique Mariano Pedroso DDS MSc , Sebastiao Silverio Sousa-Neto DDS, MSc , Alan Roger Santos-Silva DDS, MSc, PhD , Ana Carolina Prado-Ribeiro DDS, MSc, PhD , Thaís Bianca Brandão DDS, MSc, PhD

Objective

This systematic review aimed to identify and describe the methods of mouth self-examination (MSE) used for oral cancer screening.

Study Design

A comprehensive search was conducted in six databases (PubMed, EMBASE, Scopus, LILACS, Web of Science, Cochrane Library) as well as gray literature sources (Google Scholar and ProQuest), with no restrictions on publication date or language. Eligible studies included cohort, cross-sectional, case-control, and clinical trials that evaluated MSE as a screening method for oral cancer. The risk of bias was assessed according to the design of each included study using the Joanna Briggs Institute (JBI) Critical Appraisal tools.

Results

A total of 11 studies were included in the qualitative synthesis, with sample sizes ranging from 53 to 34,766 individuals. Most studies used educational materials, such as pamphlets, face-to-face training sessions, digital media, and mobile applications. The steps involved in MSE generally included visual inspection of the oral mucosa and neck palpation, performed at differing frequencies. There was significant heterogeneity in the tools used for MSE; mirrors and light sources were most commonly reported. MSE assessment methods primarily relied on self-report, followed by questionnaires and clinical examinations.

Conclusion

The current evidence about MSE methods remains heterogeneous. The lack of standardized procedures and assessment impairs reproducibility and recommendations. Further high-quality studies are required to establish its applicability in diverse populations.

目的：本系统综述旨在确定和描述口腔自我检查（MSE）用于口腔癌筛查的方法。研究设计：在六个数据库（PubMed、EMBASE、Scopus、LILACS、Web of Science、Cochrane Library）和灰色文献源（谷歌Scholar和ProQuest）中进行全面检索，不限制出版日期和语言。符合条件的研究包括评价MSE作为口腔癌筛查方法的队列、横断面、病例对照和临床试验。使用乔安娜布里格斯研究所（JBI）关键评估工具，根据每个纳入研究的设计评估偏倚风险。结果：定性综合共纳入11项研究，样本量为53 ~ 34,766人。大多数研究使用教育材料，如小册子、面对面培训课程、数字媒体和移动应用程序。MSE所涉及的步骤通常包括口腔黏膜的视觉检查和颈部触诊，以不同的频率进行。用于MSE的工具存在显著的异质性；镜子和光源是最常见的。MSE评估方法主要依靠自我报告，其次是问卷调查和临床检查。结论：目前关于MSE方法的证据仍然不一致。缺乏标准化的程序和评估影响了可重复性和建议。需要进一步的高质量研究来确定其在不同人群中的适用性。

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