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Use of 3-dimensional (3D) Fourier domain adaptation to automatically segment teeth from numerous cone beam computed tomography (CBCT) scans
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.027
Dr. Laura Tsu , Dr. James Fishbaugh , Dr. Jared Vicory , Dr. Hassem Geha , Dr. Beatriz Paniagua , Dr. Asma Khan

Objective

Epidemiologic studies report that cracked teeth are the third most common cause of tooth loss in industrialized countries. Current diagnostic tools have a limited ability to accurately diagnose cracks. There is an imperative need to develop an objective and reliable method to detect cracks beyond information obtained from clinical and radiographic evaluation. Kitware and UT Health San Antonio School of Dentistry have developed a novel algorithm for crack detection, though it requires reliable tooth isolation, i.e. segmentation, method to work appropriately. There has been inconsistent segmentation using this algorithm when scans from different cone beam computed tomography (CBCT) machines were used. In this abstract, we present a robust convolutional neural network (CNN)-based segmentation method that works on several small field of view CBCT scans acquired by different CBCT machines.

Study Design

Data show that regular CNN segmentation models fail to generalize to new acquisitions when scanner protocols shift and upgrade, a problem known as domain shift. To overcome this, we successfully generalized 3-dimensional Fourier Domain Adaptation methods to build 3-dimensional tooth segmentation models that are robust to domain shift. The method works by finding the transformations between a source domain into an adapted target domain in the Fourier space. Applying this method to multiple small field of view CBCT scans acquired by different machines resulted in successful segmentation of the teeth, tested on multiple scans.

Results

This development enables the use of our algorithm (as well as other algorithms) on scans from a variety of CBCT machines, thus vastly improving their generalizability.

Conclusion

The access to a reliable, single tooth segmentation method will enable the early detection and localization of tooth pathology, including cracks. This along with appropriate interventions has the potential to enable effective strategies to prevent tooth loss. This technology may also be applied to other dental applications that require use of automated segmentation of teeth. Funded by National Institutes of Health/National Institute of Dental and Craniofacial Research R44DE027574
{"title":"Use of 3-dimensional (3D) Fourier domain adaptation to automatically segment teeth from numerous cone beam computed tomography (CBCT) scans","authors":"Dr. Laura Tsu ,&nbsp;Dr. James Fishbaugh ,&nbsp;Dr. Jared Vicory ,&nbsp;Dr. Hassem Geha ,&nbsp;Dr. Beatriz Paniagua ,&nbsp;Dr. Asma Khan","doi":"10.1016/j.oooo.2024.11.027","DOIUrl":"10.1016/j.oooo.2024.11.027","url":null,"abstract":"<div><h3>Objective</h3><div>Epidemiologic studies report that cracked teeth are the third most common cause of tooth loss in industrialized countries. Current diagnostic tools have a limited ability to accurately diagnose cracks. There is an imperative need to develop an objective and reliable method to detect cracks beyond information obtained from clinical and radiographic evaluation. Kitware and UT Health San Antonio School of Dentistry have developed a novel algorithm for crack detection, though it requires reliable tooth isolation, i.e. segmentation, method to work appropriately. There has been inconsistent segmentation using this algorithm when scans from different cone beam computed tomography (CBCT) machines were used. In this abstract, we present a robust convolutional neural network (CNN)-based segmentation method that works on several small field of view CBCT scans acquired by different CBCT machines.</div></div><div><h3>Study Design</h3><div>Data show that regular CNN segmentation models fail to generalize to new acquisitions when scanner protocols shift and upgrade, a problem known as domain shift. To overcome this, we successfully generalized 3-dimensional Fourier Domain Adaptation methods to build 3-dimensional tooth segmentation models that are robust to domain shift. The method works by finding the transformations between a source domain into an adapted target domain in the Fourier space. Applying this method to multiple small field of view CBCT scans acquired by different machines resulted in successful segmentation of the teeth, tested on multiple scans.</div></div><div><h3>Results</h3><div>This development enables the use of our algorithm (as well as other algorithms) on scans from a variety of CBCT machines, thus vastly improving their generalizability.</div></div><div><h3>Conclusion</h3><div>The access to a reliable, single tooth segmentation method will enable the early detection and localization of tooth pathology, including cracks. This along with appropriate interventions has the potential to enable effective strategies to prevent tooth loss. This technology may also be applied to other dental applications that require use of automated segmentation of teeth. Funded by National Institutes of Health/National Institute of Dental and Craniofacial Research R44DE027574</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e77"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mandibular osseous and dental involvement in progressive hemifacial atrophy: a case report
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.025
Dr. Marta C.L. Somaschini , Dr. Tina Meisami , Dr. Susanne E. Perschbacher

Clinical Presentation

This case report describes a 19-year-old male patient with progressive hemifacial atrophy (PHA), also known as Parry-Romberg syndrome, a rare condition characterized by gradual atrophy of facial hard and soft tissues of unknown etiology. The patient sought consultation to correct facial asymmetry, which had been progressive since childhood. Clinical examination revealed a smaller right lower half of the face compared with the left. There was no linear scleroderma present. The patient had no history of trauma. The malar region and external ear were normal. A craniofacial cone beam computed tomography scan was acquired for presurgical planning and submitted for oral and maxillofacial radiology review. Radiologic examination revealed hypoplasia of the right body of the mandible but normal temporomandibular joint structures. Dental abnormalities also were noted, including root resorption and a missing mandibular premolar on the affected side. There was severe atrophy of the facial soft tissues on the right, particularly near the symphyseal/parasymphyseal area.

Differential Diagnosis

Diagnosis of PHA requires ruling out other causes of unilateral facial hypoplasia including idiopathic or trauma-induced mandibular hypoplasia and oculo-auricular-vertebral spectrum. The normal temporomandibular joint structures and severe atrophy of the facial soft tissues with a history of progressive changes during childhood favor a diagnosis of PHA.

Diagnosis and Management

On the basis of the clinical presentation and radiographic findings, a diagnosis of PHA was made. The management plan included onlay mandibular angle and body implant surgery to address the facial asymmetry, with a second step planned for fat grafting to address the soft tissue deficiency.

Conclusion

This case report presents features of PHA including rarely-reported osseous and dental changes in the mandible. The diagnosis relies on a combination of radiographic exclusions and clinical examination. Management involves correction of osseous and soft tissue defects to help mitigate the aesthetic and functional impact of this condition.
{"title":"Mandibular osseous and dental involvement in progressive hemifacial atrophy: a case report","authors":"Dr. Marta C.L. Somaschini ,&nbsp;Dr. Tina Meisami ,&nbsp;Dr. Susanne E. Perschbacher","doi":"10.1016/j.oooo.2024.11.025","DOIUrl":"10.1016/j.oooo.2024.11.025","url":null,"abstract":"<div><h3>Clinical Presentation</h3><div>This case report describes a 19-year-old male patient with progressive hemifacial atrophy (PHA), also known as Parry-Romberg syndrome, a rare condition characterized by gradual atrophy of facial hard and soft tissues of unknown etiology. The patient sought consultation to correct facial asymmetry, which had been progressive since childhood. Clinical examination revealed a smaller right lower half of the face compared with the left. There was no linear scleroderma present. The patient had no history of trauma. The malar region and external ear were normal. A craniofacial cone beam computed tomography scan was acquired for presurgical planning and submitted for oral and maxillofacial radiology review. Radiologic examination revealed hypoplasia of the right body of the mandible but normal temporomandibular joint structures. Dental abnormalities also were noted, including root resorption and a missing mandibular premolar on the affected side. There was severe atrophy of the facial soft tissues on the right, particularly near the symphyseal/parasymphyseal area.</div></div><div><h3>Differential Diagnosis</h3><div>Diagnosis of PHA requires ruling out other causes of unilateral facial hypoplasia including idiopathic or trauma-induced mandibular hypoplasia and oculo-auricular-vertebral spectrum. The normal temporomandibular joint structures and severe atrophy of the facial soft tissues with a history of progressive changes during childhood favor a diagnosis of PHA.</div></div><div><h3>Diagnosis and Management</h3><div>On the basis of the clinical presentation and radiographic findings, a diagnosis of PHA was made. The management plan included onlay mandibular angle and body implant surgery to address the facial asymmetry, with a second step planned for fat grafting to address the soft tissue deficiency.</div></div><div><h3>Conclusion</h3><div>This case report presents features of PHA including rarely-reported osseous and dental changes in the mandible. The diagnosis relies on a combination of radiographic exclusions and clinical examination. Management involves correction of osseous and soft tissue defects to help mitigate the aesthetic and functional impact of this condition.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e76"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vertebral artery calcifications: a comprehensive review
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.070
Ms. Laasya Kodali , Ms. Kara Vig , Dr. Ali Syed

Clinical Presentation

Vertebral artery calcifications are a significant finding in medical imaging and often are associated with cerebrovascular diseases. Vertebral artery calcifications are characterized by the accumulation of calcium within the walls of the vertebral arteries. There are several risk factors that have been associated with the development of vertebral artery calcifications, including age, hypertension, diabetes mellitus, dyslipidemia, smoking, and chronic kidney disease. The prevalence of vertebral artery calcifications is known to affect 21% of the general population and is common in the elderly. The presence of vertebral artery calcifications has also been linked to an increased risk of transient ischemic attacks and strokes which could cause death.

Differential Diagnosis

Radiographically, vertebral artery calcifications appear either unilaterally or bilaterally at the level of the foramen magnum, appearing as circular or semi-circular masses. These characteristic features are pathognomonic of vertebral artery calcifications.

Diagnosis and Management

Noninvasive techniques, such as computed tomography and magnetic resonance imaging, are commonly used to visualize and quantify the extent of vertebral artery calcifications. Additionally, ultrasonography can be used to assess the flow characteristics of vertebral arteries in relation to vertebral artery calcifications. The treatment of vertebral artery calcifications involves addressing underlying risk factors to prevent further progression of arterial calcification. Lifestyle modifications, including smoking cessation, blood pressure control, lipid management, and glycemic control, play a crucial role in reducing the burden. In severe cases, surgical interventions such as endovascular procedures or surgical bypass may be considered to restore normal blood flow.

Conclusion

Vertebral artery calcifications represent an important clinical entity associated with cerebrovascular diseases. Recognizing the risk factors, understanding the pathophysiology, and using appropriate diagnostic tools are essential for early detection and effective management. Further research is warranted to explore the optimal therapeutic strategies and long-term outcomes related to vertebral artery calcifications.
{"title":"Vertebral artery calcifications: a comprehensive review","authors":"Ms. Laasya Kodali ,&nbsp;Ms. Kara Vig ,&nbsp;Dr. Ali Syed","doi":"10.1016/j.oooo.2024.11.070","DOIUrl":"10.1016/j.oooo.2024.11.070","url":null,"abstract":"<div><h3>Clinical Presentation</h3><div>Vertebral artery calcifications are a significant finding in medical imaging and often are associated with cerebrovascular diseases. Vertebral artery calcifications are characterized by the accumulation of calcium within the walls of the vertebral arteries. There are several risk factors that have been associated with the development of vertebral artery calcifications, including age, hypertension, diabetes mellitus, dyslipidemia, smoking, and chronic kidney disease. The prevalence of vertebral artery calcifications is known to affect 21% of the general population and is common in the elderly. The presence of vertebral artery calcifications has also been linked to an increased risk of transient ischemic attacks and strokes which could cause death.</div></div><div><h3>Differential Diagnosis</h3><div>Radiographically, vertebral artery calcifications appear either unilaterally or bilaterally at the level of the foramen magnum, appearing as circular or semi-circular masses. These characteristic features are pathognomonic of vertebral artery calcifications.</div></div><div><h3>Diagnosis and Management</h3><div>Noninvasive techniques, such as computed tomography and magnetic resonance imaging, are commonly used to visualize and quantify the extent of vertebral artery calcifications. Additionally, ultrasonography can be used to assess the flow characteristics of vertebral arteries in relation to vertebral artery calcifications. The treatment of vertebral artery calcifications involves addressing underlying risk factors to prevent further progression of arterial calcification. Lifestyle modifications, including smoking cessation, blood pressure control, lipid management, and glycemic control, play a crucial role in reducing the burden. In severe cases, surgical interventions such as endovascular procedures or surgical bypass may be considered to restore normal blood flow.</div></div><div><h3>Conclusion</h3><div>Vertebral artery calcifications represent an important clinical entity associated with cerebrovascular diseases. Recognizing the risk factors, understanding the pathophysiology, and using appropriate diagnostic tools are essential for early detection and effective management. Further research is warranted to explore the optimal therapeutic strategies and long-term outcomes related to vertebral artery calcifications.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e94"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Goldenhar syndrome: report of rare findings in the cervical spine, coronoid process, and temporal bone
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.016
Dr. Colin LaPrade , Dr. Alexander Cruz Walma , Dr. André Mol

Introduction

Goldenhar syndrome is a rare developmental condition considered by some to be a variant of hemifacial microsomia. In 1991, Vento et al. described the O.M.E.N.S. classification for hemifacial microsomia (HM), further supporting the consideration of Goldenhar syndrome as an HM subtype as the result of effects on the orbit, mandible, ear, facial nerve, and soft tissues.

Clinical Presentation

This report presents the case of a 16-year-old female patient diagnosed with Goldenhar syndrome shortly after birth. Anonymized findings from recent cone beam computed tomography will be presented in addition to those of multidetector computed tomography acquired over the course of surgical management. Key findings include unilateral coronoid hyperplasia of the unaffected side, pseudo-joint formation from the left transverse process of C1 to the occipital condyle, and proliferation of the temporal bone with an appearance suggestive of fibro-osseous disease.

Differential Diagnosis

Anomalies of the coronoid process and cervical spine are likely accounted for by the patient's diagnosed developmental anomaly. A case with a similar presentation of the coronoid process could not be found in the literature, whereas the patient's vertebral anomalies are not dissimilar to a limited number of cases reported in 2017 by Renkema et al. Fibrous dysplasia may account for the presentation of the patient's temporal bone on the affected side.

Diagnosis and Management

Surgical procedures pursued to address the patient's diagnosed condition included multiple rib grafts, distraction osteogenesis, surgeries to address microtia on the affected side, an inverted L-osteotomy, and open reduction with internal fixation.

Conclusion

This case represents a unique combination of vertebral, mandibular, and temporal bone anomalies yet to be reported in the literature.
{"title":"Goldenhar syndrome: report of rare findings in the cervical spine, coronoid process, and temporal bone","authors":"Dr. Colin LaPrade ,&nbsp;Dr. Alexander Cruz Walma ,&nbsp;Dr. André Mol","doi":"10.1016/j.oooo.2024.11.016","DOIUrl":"10.1016/j.oooo.2024.11.016","url":null,"abstract":"<div><h3>Introduction</h3><div>Goldenhar syndrome is a rare developmental condition considered by some to be a variant of hemifacial microsomia. In 1991, Vento et al. described the O.M.E.N.S. classification for hemifacial microsomia (HM), further supporting the consideration of Goldenhar syndrome as an HM subtype as the result of effects on the orbit, mandible, ear, facial nerve, and soft tissues.</div></div><div><h3>Clinical Presentation</h3><div>This report presents the case of a 16-year-old female patient diagnosed with Goldenhar syndrome shortly after birth. Anonymized findings from recent cone beam computed tomography will be presented in addition to those of multidetector computed tomography acquired over the course of surgical management. Key findings include unilateral coronoid hyperplasia of the unaffected side, pseudo-joint formation from the left transverse process of C1 to the occipital condyle, and proliferation of the temporal bone with an appearance suggestive of fibro-osseous disease.</div></div><div><h3>Differential Diagnosis</h3><div>Anomalies of the coronoid process and cervical spine are likely accounted for by the patient's diagnosed developmental anomaly. A case with a similar presentation of the coronoid process could not be found in the literature, whereas the patient's vertebral anomalies are not dissimilar to a limited number of cases reported in 2017 by Renkema et al. Fibrous dysplasia may account for the presentation of the patient's temporal bone on the affected side.</div></div><div><h3>Diagnosis and Management</h3><div>Surgical procedures pursued to address the patient's diagnosed condition included multiple rib grafts, distraction osteogenesis, surgeries to address microtia on the affected side, an inverted L-osteotomy, and open reduction with internal fixation.</div></div><div><h3>Conclusion</h3><div>This case represents a unique combination of vertebral, mandibular, and temporal bone anomalies yet to be reported in the literature.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e73"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the leaded-glasses as an exomass object on cone beam computed tomography (CBCT) images
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.014
Dr. Solaleh Shahmirzadi , Dr. Madhu Nair , Dr. Mehrnaz Tahmasbi , Prof. Mikhail Umorin , Dr. Hui Liang

Objectives

To investigate the effect of artifacts in cone beam computed tomography (CBCT) arising from leaded-glasses in the exomass on detection of root fracture (RF) and MB2 and to test different image-acquisition parameters to reduce these artifacts.

Study Design

CBCT scans of a cadaver head were acquired using the 3D-Accuitomo-170 with field of view of 100 × 50 mm. The scanning parameters included three conditions: standard/high resolution, full/partial rotations, and with/without leaded-glasses. Six evaluators assessed the images for the presence of RF and MB2 as well as the overall image quality. Artifact measurement was performed at different distances from the exomass by calculating the standard deviation of gray values in 3 specified axial slices. The effects of the parameters and their interactions were evaluated using analysis of variance.

Results

The study found that various resolutions, rotation 360°/180°, and the presence/absence of the exomass did not have a statistically significant effect on the detection of RF. However, the present of exomass had a significant negative effect on identifying MB2, indicating that the readers were less able to detect MB2 when exomass were present. The effects of the rotation angles and resolutions were not statistically significant. The present of the exomass had a significant negative effect on image quality, whereas wider arc rotations and higher resolution had a significantly positive effect on image quality. Artifact intensity, as measured by standard deviation values, was highest in the closest slices to the exomass, followed by middle slices, and lowest in farther slices (P < .05).

Conclusion

The presence of metallic exomass in CBCT scans creates artifacts that lower image quality. However, the detection of RF is unaffected by these artifacts. Therefore, patients with suspected RF can wear leaded-glasses during CBCT scans to reduce radiation dose to the eye and lower the risk of developing cataracts.
{"title":"Effect of the leaded-glasses as an exomass object on cone beam computed tomography (CBCT) images","authors":"Dr. Solaleh Shahmirzadi ,&nbsp;Dr. Madhu Nair ,&nbsp;Dr. Mehrnaz Tahmasbi ,&nbsp;Prof. Mikhail Umorin ,&nbsp;Dr. Hui Liang","doi":"10.1016/j.oooo.2024.11.014","DOIUrl":"10.1016/j.oooo.2024.11.014","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the effect of artifacts in cone beam computed tomography (CBCT) arising from leaded-glasses in the exomass on detection of root fracture (RF) and MB2 and to test different image-acquisition parameters to reduce these artifacts.</div></div><div><h3>Study Design</h3><div>CBCT scans of a cadaver head were acquired using the 3D-Accuitomo-170 with field of view of 100 × 50 mm. The scanning parameters included three conditions: standard/high resolution, full/partial rotations, and with/without leaded-glasses. Six evaluators assessed the images for the presence of RF and MB2 as well as the overall image quality. Artifact measurement was performed at different distances from the exomass by calculating the standard deviation of gray values in 3 specified axial slices. The effects of the parameters and their interactions were evaluated using analysis of variance.</div></div><div><h3>Results</h3><div>The study found that various resolutions, rotation 360°/180°, and the presence/absence of the exomass did not have a statistically significant effect on the detection of RF. However, the present of exomass had a significant negative effect on identifying MB2, indicating that the readers were less able to detect MB2 when exomass were present. The effects of the rotation angles and resolutions were not statistically significant. The present of the exomass had a significant negative effect on image quality, whereas wider arc rotations and higher resolution had a significantly positive effect on image quality. Artifact intensity, as measured by standard deviation values, was highest in the closest slices to the exomass, followed by middle slices, and lowest in farther slices (<em>P</em> &lt; .05).</div></div><div><h3>Conclusion</h3><div>The presence of metallic exomass in CBCT scans creates artifacts that lower image quality. However, the detection of RF is unaffected by these artifacts. Therefore, patients with suspected RF can wear leaded-glasses during CBCT scans to reduce radiation dose to the eye and lower the risk of developing cataracts.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e72"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ameloblastoma of the jaws—a clinical and radiographic retrospective study
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.018
Dr. Dena Abderbwih , Dr. Ghaidaa Badabaan , Dr. Anita Gohel

Objective

Ameloblastoma is a rare, benign, slowly growing, locally aggressive odontogenic neoplasm. The aim of our study was to evaluate the incidence, patient demographics, clinical and radiographic presentations of ameloblastoma.

Study Design

This retrospective study reviewed a total of 2500 patients at the University of Florida Health Science Center and Shands hospital with a diagnosis of benign and malignant tumors to look for ameloblastoma cases from January 2011 to June 2023. There were 43 patients diagnosed as having ameloblastomas. Only 38 were included in this study. The inclusion criteria were patients with a confirmed biopsy and a radiograph prior to surgical management.

Results

The age range was between 9 and 79 years, with a mean of 42.6 years with equal number of cases seen between males and females. In total, 92% of these lesions were in the mandible with 83% in the posterior region. There was an equal distribution between unilocular and multilocular cases. One case was diagnosed as ameloblastic carcinoma. There was a significant correlation between the patient's age and the locularity of the lesion, with unilocular lesions occurring more in younger patients under 18 (P < .5). In total, 29% were located pericoronally and 64% of them were unilocular. 94% of cases had expansion, 97% with cortical thinning and 79% had displacement of adjacent structures.

Conclusion

Unilocular lesions are predominant in younger patients. Most pericoronal ameloblastomas were unilocular and all were located in the posterior mandible.
{"title":"Ameloblastoma of the jaws—a clinical and radiographic retrospective study","authors":"Dr. Dena Abderbwih ,&nbsp;Dr. Ghaidaa Badabaan ,&nbsp;Dr. Anita Gohel","doi":"10.1016/j.oooo.2024.11.018","DOIUrl":"10.1016/j.oooo.2024.11.018","url":null,"abstract":"<div><h3>Objective</h3><div>Ameloblastoma is a rare, benign, slowly growing, locally aggressive odontogenic neoplasm. The aim of our study was to evaluate the incidence, patient demographics, clinical and radiographic presentations of ameloblastoma.</div></div><div><h3>Study Design</h3><div>This retrospective study reviewed a total of 2500 patients at the University of Florida Health Science Center and Shands hospital with a diagnosis of benign and malignant tumors to look for ameloblastoma cases from January 2011 to June 2023. There were 43 patients diagnosed as having ameloblastomas. Only 38 were included in this study. The inclusion criteria were patients with a confirmed biopsy and a radiograph prior to surgical management.</div></div><div><h3>Results</h3><div>The age range was between 9 and 79 years, with a mean of 42.6 years with equal number of cases seen between males and females. In total, 92% of these lesions were in the mandible with 83% in the posterior region. There was an equal distribution between unilocular and multilocular cases. One case was diagnosed as ameloblastic carcinoma. There was a significant correlation between the patient's age and the locularity of the lesion, with unilocular lesions occurring more in younger patients under 18 (<em>P</em> &lt; .5). In total, 29% were located pericoronally and 64% of them were unilocular. 94% of cases had expansion, 97% with cortical thinning and 79% had displacement of adjacent structures.</div></div><div><h3>Conclusion</h3><div>Unilocular lesions are predominant in younger patients. Most pericoronal ameloblastomas were unilocular and all were located in the posterior mandible.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e74"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of artificial intelligence (AI) in interproximal decay detection
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.023
Dr. Jennie Caldwell , Mr. Brandon Crowther , Dr. Anita Gohel

Objective

Untreated caries are a prevalent health condition worldwide. Management of caries includes preventive and restoring teeth and function when necessary. In recent years, significant progress has been made with the introduction of artificial intelligence algorithms in dentistry, which includes diagnosis of incipient and advanced carious lesions. The objective of this study is to determine the sensitivity and specificity of Overjet Caries Assist (OCA), a radiologic automated concurrent read computer-assisted detection software, on incipient enamel and dentinal caries.

Study Design

In total, 1142 proximal surfaces were assessed in 200 bitewing images by an oral radiology resident and a calibrated dental student. The presence of incipient decay was recorded and then OCA was used. Caries successfully identified by the software, incorrectly identified, and missed lesions were recorded. The same process was then performed on 535 proximal surfaces in 50 bitewing images, and the presence of dentinal decay was recorded and the same recording process above was repeated. Sensitivity and specificity calculations were performed.

Results

The data revealed a sensitivity of nearly 70% for incipient caries and a specificity of approximately 98%. The sensitivity of dentin caries was found to be nearly 94%, with a specificity of 97%.

Conclusion

In general, human sensitivity of detection of proximal carious lesions ranges from 24% to 43% and specificity is 89% to 97%. Our results indicate that OCA is overall accurate, with greater sensitivity and specificity on proximal carious lesions and markedly high sensitivity for dentinal lesions. Artificial intelligence models have the ability to provide a reliable tool in assisting in the diagnosis of caries.
{"title":"The use of artificial intelligence (AI) in interproximal decay detection","authors":"Dr. Jennie Caldwell ,&nbsp;Mr. Brandon Crowther ,&nbsp;Dr. Anita Gohel","doi":"10.1016/j.oooo.2024.11.023","DOIUrl":"10.1016/j.oooo.2024.11.023","url":null,"abstract":"<div><h3>Objective</h3><div>Untreated caries are a prevalent health condition worldwide. Management of caries includes preventive and restoring teeth and function when necessary. In recent years, significant progress has been made with the introduction of artificial intelligence algorithms in dentistry, which includes diagnosis of incipient and advanced carious lesions. The objective of this study is to determine the sensitivity and specificity of Overjet Caries Assist (OCA), a radiologic automated concurrent read computer-assisted detection software, on incipient enamel and dentinal caries.</div></div><div><h3>Study Design</h3><div>In total, 1142 proximal surfaces were assessed in 200 bitewing images by an oral radiology resident and a calibrated dental student. The presence of incipient decay was recorded and then OCA was used. Caries successfully identified by the software, incorrectly identified, and missed lesions were recorded. The same process was then performed on 535 proximal surfaces in 50 bitewing images, and the presence of dentinal decay was recorded and the same recording process above was repeated. Sensitivity and specificity calculations were performed.</div></div><div><h3>Results</h3><div>The data revealed a sensitivity of nearly 70% for incipient caries and a specificity of approximately 98%. The sensitivity of dentin caries was found to be nearly 94%, with a specificity of 97%.</div></div><div><h3>Conclusion</h3><div>In general, human sensitivity of detection of proximal carious lesions ranges from 24% to 43% and specificity is 89% to 97%. Our results indicate that OCA is overall accurate, with greater sensitivity and specificity on proximal carious lesions and markedly high sensitivity for dentinal lesions. Artificial intelligence models have the ability to provide a reliable tool in assisting in the diagnosis of caries.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Pages e75-e76"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiographic features of recurrent glandular odontogenic cysts
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.042
Dr. Suvendra Vijayan , Mr. Neil Sudan , Ms. Jeyda Turker , Mr. Matthew Jenny , Dr. Elizabeth Ann Bilodeau

Introduction

We present a case series of recurrent glandular odontogenic cysts (rGOC), a rare, aggressive odontogenic cyst seen commonly in the anterior mandible of middle-aged women with reported recurrence rates of 22%. Some of the histologic features present in GOCs are nonspecific and may be present in other odontogenic cysts (e.g. mucous cells, apocrine snouting, ciliating, multiple compartments). Our objective is to analyze the radiographic features of rGOCs from our institution.

Study Design

The University of Pittsburgh Pathology archives were searched for rGOCs (1993-2022). In total, 265 glandular odontogenic cysts were diagnosed with a recurrence rate of 2.3%. We reviewed the pathology reports and available imaging for the clinicopathologic features of our recurrent cases and paired primary cases, when available.

Results

We assembled a series of 6 patients with 7 rGOCs, with one patient having 2 recurrences. Average time to recurrence was 10.7 years (range 2.3-22.6 years), with a mean age at initial diagnosis of 50.3 years (range 24-69) and no sex predilection (male:female 1:1). All cases presented in the anterior gnathic region with an even jaw distribution (maxilla:mandible 1:1).
Radiographic descriptions were available on all cases. Primary radiology was available for review in 3 cases. The mean size (greatest dimension) was 2.5 cm (range 1.0-4.0 cm). Lesions were multilocular, associated with the periapex of the teeth. Other features observed included root resorption, perforation of the cortex, and tooth displacement.

Conclusions

In our single institution experience, rGOC are most common in the anterior gnathic region with lower recurrence rates than stated in the literature. Given the overlapping histologic features used criteria for the diagnosis of GOC, radiographic correlation may be important in the diagnosis of equivocal odontogenic cysts with GOC-like features.
{"title":"Radiographic features of recurrent glandular odontogenic cysts","authors":"Dr. Suvendra Vijayan ,&nbsp;Mr. Neil Sudan ,&nbsp;Ms. Jeyda Turker ,&nbsp;Mr. Matthew Jenny ,&nbsp;Dr. Elizabeth Ann Bilodeau","doi":"10.1016/j.oooo.2024.11.042","DOIUrl":"10.1016/j.oooo.2024.11.042","url":null,"abstract":"<div><h3>Introduction</h3><div>We present a case series of recurrent glandular odontogenic cysts (rGOC), a rare, aggressive odontogenic cyst seen commonly in the anterior mandible of middle-aged women with reported recurrence rates of 22%. Some of the histologic features present in GOCs are nonspecific and may be present in other odontogenic cysts (e.g. mucous cells, apocrine snouting, ciliating, multiple compartments). Our objective is to analyze the radiographic features of rGOCs from our institution.</div></div><div><h3>Study Design</h3><div>The University of Pittsburgh Pathology archives were searched for rGOCs (1993-2022). In total, 265 glandular odontogenic cysts were diagnosed with a recurrence rate of 2.3%. We reviewed the pathology reports and available imaging for the clinicopathologic features of our recurrent cases and paired primary cases, when available.</div></div><div><h3>Results</h3><div>We assembled a series of 6 patients with 7 rGOCs, with one patient having 2 recurrences. Average time to recurrence was 10.7 years (range 2.3-22.6 years), with a mean age at initial diagnosis of 50.3 years (range 24-69) and no sex predilection (male:female 1:1). All cases presented in the anterior gnathic region with an even jaw distribution (maxilla:mandible 1:1).</div><div>Radiographic descriptions were available on all cases. Primary radiology was available for review in 3 cases. The mean size (greatest dimension) was 2.5 cm (range 1.0-4.0 cm). Lesions were multilocular, associated with the periapex of the teeth. Other features observed included root resorption, perforation of the cortex, and tooth displacement.</div></div><div><h3>Conclusions</h3><div>In our single institution experience, rGOC are most common in the anterior gnathic region with lower recurrence rates than stated in the literature. Given the overlapping histologic features used criteria for the diagnosis of GOC, radiographic correlation may be important in the diagnosis of equivocal odontogenic cysts with GOC-like features.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e83"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suboptimal patient positioning with panoramic and cone beam computed tomography (CBCT) imaging: effects on dose
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.017
Dr. Colin LaPrade , Prof. Brandon Johnson , Dr. Angela Broome , Dr. André Mol , Dr. Marija Ivanovic , Dr. John Ludlow

Objective

The aim of this study is to examine the effects of various changes in patient positioning on radiation exposure for panoramic and cone beam computed tomography (CBCT) extraoral radiographic examinations. Specific objectives include measuring equivalent and effective dose by means of radiation dosimetry with a tissue-equivalent phantom for each modality, with intentional changes in position to the craniofacial complex.

Study Design

Simulated panoramic and CBCT radiographic examinations at optimal positioning in addition to 6 suboptimal positions—anterior, posterior, and lateral shifts by 1 cm; and neck extension (i.e., chin tilted up), flexion (i.e., chin tiled down), and rotation by 10 degrees—were completed using an adult tissue-equivalent phantom. Dosimetry was acquired using optically stimulated luminescence dosimeters placed at 24 anatomical sites in the head/neck region. Exposures were made with the RayScan Alpha Plus x-ray unit using the following exposure parameters for panoramic imaging: 13.9 seconds, 80 kVp, 14 mA; and for CBCT: 14.0 seconds, 90 kVp, 11 mA. Five CBCT and 10 panoramic exposures, respectively, were made to ensure adequate exposure to all sites of interest.

Results

No increases in E were determined for suboptimal panoramic conditions. E for anterior shift (26.9 μSv) and posterior shift (28.1 μSv) demonstrated statistically-significant decreases (P < .001) when compared with optimal positioning (50.0 μSv). For CBCT, no statistically significant changes for E were determined, although equivalent thyroid dose was significantly increased (P = .003) when the chin was titled down (1882.7 μSv) in comparison with optimal positioning (1674.4 μSv).

Conclusions

No suboptimal positions resulted in significant increases in E for either CBCT or panoramic imaging. Initial results suggest that tilting the chin down may increase exposure to the thyroid gland for CBCT imaging. Additional exposures at smaller fields of view are warranted, in addition to exposures with a stabilized thyroid gland position.
{"title":"Suboptimal patient positioning with panoramic and cone beam computed tomography (CBCT) imaging: effects on dose","authors":"Dr. Colin LaPrade ,&nbsp;Prof. Brandon Johnson ,&nbsp;Dr. Angela Broome ,&nbsp;Dr. André Mol ,&nbsp;Dr. Marija Ivanovic ,&nbsp;Dr. John Ludlow","doi":"10.1016/j.oooo.2024.11.017","DOIUrl":"10.1016/j.oooo.2024.11.017","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to examine the effects of various changes in patient positioning on radiation exposure for panoramic and cone beam computed tomography (CBCT) extraoral radiographic examinations. Specific objectives include measuring equivalent and effective dose by means of radiation dosimetry with a tissue-equivalent phantom for each modality, with intentional changes in position to the craniofacial complex.</div></div><div><h3>Study Design</h3><div>Simulated panoramic and CBCT radiographic examinations at optimal positioning in addition to 6 suboptimal positions—anterior, posterior, and lateral shifts by 1 cm; and neck extension (i.e., chin tilted up), flexion (i.e., chin tiled down), and rotation by 10 degrees—were completed using an adult tissue-equivalent phantom. Dosimetry was acquired using optically stimulated luminescence dosimeters placed at 24 anatomical sites in the head/neck region. Exposures were made with the RayScan Alpha Plus x-ray unit using the following exposure parameters for panoramic imaging: 13.9 seconds, 80 kVp, 14 mA; and for CBCT: 14.0 seconds, 90 kVp, 11 mA. Five CBCT and 10 panoramic exposures, respectively, were made to ensure adequate exposure to all sites of interest.</div></div><div><h3>Results</h3><div>No increases in E were determined for suboptimal panoramic conditions. E for anterior shift (26.9 μSv) and posterior shift (28.1 μSv) demonstrated statistically-significant decreases (<em>P</em> &lt; .001) when compared with optimal positioning (50.0 μSv). For CBCT, no statistically significant changes for E were determined, although equivalent thyroid dose was significantly increased (<em>P</em> = .003) when the chin was titled down (1882.7 μSv) in comparison with optimal positioning (1674.4 μSv).</div></div><div><h3>Conclusions</h3><div>No suboptimal positions resulted in significant increases in E for either CBCT or panoramic imaging. Initial results suggest that tilting the chin down may increase exposure to the thyroid gland for CBCT imaging. Additional exposures at smaller fields of view are warranted, in addition to exposures with a stabilized thyroid gland position.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e73"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study of accuracy and reliability of intraoral ultrasound using ex vivo and in vivo data
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-02-04 DOI: 10.1016/j.oooo.2024.11.074
Mr. Jiaqing Wang , Mr. Lucas Graf-Alexiou , Dr. Kim-Cuong T. Nguyen , Ms. Trang H. Hoang , Prof. Paul Major , Prof. Lawrence H. Le

Objective

This study aimed to evaluate the reliability and accuracy of intraoral ultrasound (US) imaging for assessing periodontal parameters.

Study Design

Measurements from human cadavers and orthodontic patients were used to evaluate the accuracy and reliability of high-frequency (20 MHz) intraoral ultrasonography. First, measurement accuracy was assessed on US and micro-computed tomography (μCT) images for the maxillary and mandibular teeth from 3 cadavers (aged 62, 70, and 75 years), which were donated by the Department of Anatomy at the University of Alberta. Fifty pairs of US and corresponding μCT images were selected for measurements. Two trained raters measured the alveolar bone level (ABL) between the cementum-enamel junction and the alveolar bone crest (ABC), and the thickness of the alveolar bone near its crest (ABT) on both types of images, following a 2-week calibration exercise. The accuracy was evaluated using t tests, and Bland-Altman plots. Second, reliability evaluation was conducted on clinical US images of 134 teeth including central incisors, lateral incisors, canines, and premolars from 19 adolescent orthodontic patients. Three raters performed measurements of 4 parameters twice on the clinical US images: ABL, ABT, the gingiva thickness close to the ABC (GT1), and the gingiva thickness 2 mm away from the gingival margin (GT2). The intra- and inter-rater reliabilities were evaluated using the intraclass correlation coefficient.

Results

Accuracy evaluation revealed low bias in Bland-Altman analysis, and the t tests had P values > .2. Reliability evaluation demonstrated excellent intraclass correlation coefficient scores (>0.9) for ABL, GC1, and GC2, and good scores (>0.8) for ABT measurements in both inter- and intra-rater analyses on US.

Conclusion

The accuracy analysis on the cadavers showed no statistically significant difference in measurements between US and μCT. The reliability analysis on clinical data demonstrated high intra- and inter-rater reliabilities for the periodontal measurements.
{"title":"A study of accuracy and reliability of intraoral ultrasound using ex vivo and in vivo data","authors":"Mr. Jiaqing Wang ,&nbsp;Mr. Lucas Graf-Alexiou ,&nbsp;Dr. Kim-Cuong T. Nguyen ,&nbsp;Ms. Trang H. Hoang ,&nbsp;Prof. Paul Major ,&nbsp;Prof. Lawrence H. Le","doi":"10.1016/j.oooo.2024.11.074","DOIUrl":"10.1016/j.oooo.2024.11.074","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the reliability and accuracy of intraoral ultrasound (US) imaging for assessing periodontal parameters.</div></div><div><h3>Study Design</h3><div>Measurements from human cadavers and orthodontic patients were used to evaluate the accuracy and reliability of high-frequency (20 MHz) intraoral ultrasonography. First, measurement accuracy was assessed on US and micro-computed tomography (<em>μ</em>CT) images for the maxillary and mandibular teeth from 3 cadavers (aged 62, 70, and 75 years), which were donated by the Department of Anatomy at the University of Alberta. Fifty pairs of US and corresponding <em>μ</em>CT images were selected for measurements. Two trained raters measured the alveolar bone level (ABL) between the cementum-enamel junction and the alveolar bone crest (ABC), and the thickness of the alveolar bone near its crest (ABT) on both types of images, following a 2-week calibration exercise. The accuracy was evaluated using <em>t</em> tests, and Bland-Altman plots. Second, reliability evaluation was conducted on clinical US images of 134 teeth including central incisors, lateral incisors, canines, and premolars from 19 adolescent orthodontic patients. Three raters performed measurements of 4 parameters twice on the clinical US images: ABL, ABT, the gingiva thickness close to the ABC (GT1), and the gingiva thickness 2 mm away from the gingival margin (GT2). The intra- and inter-rater reliabilities were evaluated using the intraclass correlation coefficient.</div></div><div><h3>Results</h3><div>Accuracy evaluation revealed low bias in Bland-Altman analysis, and the <em>t</em> tests had <em>P</em> values &gt; .2. Reliability evaluation demonstrated excellent intraclass correlation coefficient scores (&gt;0.9) for ABL, GC1, and GC2, and good scores (&gt;0.8) for ABT measurements in both inter- and intra-rater analyses on US.</div></div><div><h3>Conclusion</h3><div>The accuracy analysis on the cadavers showed no statistically significant difference in measurements between US and <em>μ</em>CT. The reliability analysis on clinical data demonstrated high intra- and inter-rater reliabilities for the periodontal measurements.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 3","pages":"Page e96"},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Oral Surgery Oral Medicine Oral Pathology Oral Radiology
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