Oral Surgery Oral Medicine Oral Pathology Oral Radiology最新文献

英文中文

Autoimmune disorders as predictive factors for oral lichen planus and malignancy risk: real-world data analysis. 自身免疫性疾病作为口腔扁平苔藓和恶性肿瘤风险的预测因素：真实世界数据分析。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-26 DOI: 10.1016/j.oooo.2025.11.012

Adepitan A Owosho, Stella O Oyewole

Objective: Oral lichen planus (OLP) is a T-cell-mediated mucosal disorder with malignant potential and ∼1% prevalence. Its associations with autoimmune diseases and oral squamous cell carcinoma (OSCC), especially among smokers, remain unclear. This study quantified OLP prevalence across 17 autoimmune disorders and evaluated OSCC risk in these cohorts.

Methods: Data from TriNetX research network were analyzed in a retrospective cohort of adults ≥18 years. Patients with one of 17 autoimmune diseases were identified via ICD-10 codes and compared to nonautoimmune controls. OLP prevalence and risk were estimated using 1:1 age- and sex-matched propensity score matching. OSCC risk in autoimmune and OLP patients was assessed via ICD-O/ICD-10 codes, and tobacco impact was evaluated.

Results: In 4,480,330 patients with autoimmune disorders, OLP prevalence was 2.04%, ranging from 1.19% in multiple sclerosis to 4.57% in Sjögren's. OLP risk was significantly elevated in 13 conditions (OR = 1.06-2.44; P < .05), nonsignificant for scleroderma, myasthenia gravis, and Hashimoto, and inversely associated with multiple sclerosis (OR = 0.78; P < .0001). OSCC risk was 1.39%, with ORs of 15.93 overall and 23.6 in smokers with autoimmune disorders and OLP (P < .0001).

Conclusions: Autoimmune interactions in OLP are complex, with robust associations in Sjögren's, vasculitis, Addison's, and intriguing multiple sclerosis protection. The markedly elevated risk of OSCC in patients with autoimmune disease and OLP highlights the need for integrated screening protocols and patient education.

目的：口腔扁平苔藓（OLP）是一种具有恶性潜能的t细胞介导的粘膜疾病，患病率约1%。它与自身免疫性疾病和口腔鳞状细胞癌（OSCC）的关系，特别是在吸烟者中，尚不清楚。本研究量化了17种自身免疫性疾病的OLP患病率，并评估了这些队列中OSCC的风险。方法：来自TriNetX研究网络的数据在≥18岁的成年人中进行回顾性队列分析。通过ICD-10编码确定患有17种自身免疫性疾病之一的患者，并与非自身免疫性对照进行比较。使用1:1的年龄和性别匹配的倾向评分来估计OLP的患病率和风险。通过ICD-O/ICD-10代码评估自身免疫和OLP患者的OSCC风险，并评估烟草的影响。结果：在4480330例自身免疫性疾病患者中，OLP患病率为2.04%，从多发性硬化症的1.19%到Sjögren's的4.57%不等。OLP风险在13种情况下显著升高（OR = 1.06-2.44; P < 0.05），硬皮病、重症肌无力和桥本综合症的OLP风险不显著，与多发性硬化症呈负相关（OR = 0.78; P < 0.0001）。OSCC风险为1.39%，总体的or为15.93，合并自身免疫性疾病和OLP的吸烟者的or为23.6 （P < 0.0001）。结论：OLP中的自身免疫相互作用是复杂的，与Sjögren，血管炎，Addison's和有趣的多发性硬化症保护密切相关。自身免疫性疾病和OLP患者发生OSCC的风险显著升高，这凸显了综合筛查方案和患者教育的必要性。

{"title":"Autoimmune disorders as predictive factors for oral lichen planus and malignancy risk: real-world data analysis.","authors":"Adepitan A Owosho, Stella O Oyewole","doi":"10.1016/j.oooo.2025.11.012","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.11.012","url":null,"abstract":"<p><strong>Objective: </strong>Oral lichen planus (OLP) is a T-cell-mediated mucosal disorder with malignant potential and ∼1% prevalence. Its associations with autoimmune diseases and oral squamous cell carcinoma (OSCC), especially among smokers, remain unclear. This study quantified OLP prevalence across 17 autoimmune disorders and evaluated OSCC risk in these cohorts.</p><p><strong>Methods: </strong>Data from TriNetX research network were analyzed in a retrospective cohort of adults ≥18 years. Patients with one of 17 autoimmune diseases were identified via ICD-10 codes and compared to nonautoimmune controls. OLP prevalence and risk were estimated using 1:1 age- and sex-matched propensity score matching. OSCC risk in autoimmune and OLP patients was assessed via ICD-O/ICD-10 codes, and tobacco impact was evaluated.</p><p><strong>Results: </strong>In 4,480,330 patients with autoimmune disorders, OLP prevalence was 2.04%, ranging from 1.19% in multiple sclerosis to 4.57% in Sjögren's. OLP risk was significantly elevated in 13 conditions (OR = 1.06-2.44; P < .05), nonsignificant for scleroderma, myasthenia gravis, and Hashimoto, and inversely associated with multiple sclerosis (OR = 0.78; P < .0001). OSCC risk was 1.39%, with ORs of 15.93 overall and 23.6 in smokers with autoimmune disorders and OLP (P < .0001).</p><p><strong>Conclusions: </strong>Autoimmune interactions in OLP are complex, with robust associations in Sjögren's, vasculitis, Addison's, and intriguing multiple sclerosis protection. The markedly elevated risk of OSCC in patients with autoimmune disease and OLP highlights the need for integrated screening protocols and patient education.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral squamous cell carcinoma risk and magnitude of association in inherited cancer predisposition syndromes: evidence from a large real-world cohort. 口腔鳞状细胞癌的风险和与遗传性癌症易感性综合征的关联程度：来自一个大型现实世界队列的证据

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-26 DOI: 10.1016/j.oooo.2025.11.010

Stella O Oyewole, Adetokunbo B Olawuyi, Osariemen Okhuaihesuyi, Adepitan A Owosho

Objective: Inherited cancer predisposition syndromes (ICPS) are rare genetic disorders associated with an elevated cancer risk. This study evaluates oral squamous cell carcinoma (OSCC) prevalence across selected ICPS, including Fanconi anemia (FA), Plummer-Vinson syndrome, Cowden syndrome, Li-Fraumeni syndrome, dyskeratosis congenita, and xeroderma pigmentosum, quantifies risk magnitude, examines age at diagnosis, and assesses tobacco's modifying effect on OSCC risk in these populations.

Study design: We conducted a retrospective cohort study using the TriNetX Research Network, including patients with or without ICPS identified by ICD‑10 codes over a 20‑year period. OSCC cases were matched 1:1 by age and sex to controls. The analyses assessed prevalence, odds ratios, age at diagnosis, and the impact of tobacco use. Statistical significance was set at P < .05.

Results: The prevalence of OSCC among ICPS patients ranged from 0.11% to 4.66%, with the highest in patients with FA. Among ICPS, only FA showed a markedly increased OSCC risk (OR = 40.63, P < .01), while Plummer-Vinson syndrome and dyskeratosis congenita were inversely associated. Patients with ICPS developed OSCC at younger ages (P < .0001). Smoking increased OSCC risk within ICPS (OR = 1.47), whereas nonsmokers with ICPS had a reduced risk (OR = 0.78).

Conclusions: FA is strongly associated with OSCC; OSCC also occurs in Li-Fraumeni syndrome and Cowden syndrome. Patients with ICPS present with OSCC at a younger age, supporting targeted screening for high‑risk ICPS populations.

目的：遗传性癌症易感性综合征（ICPS）是一种罕见的与癌症风险升高相关的遗传性疾病。本研究评估了口腔鳞状细胞癌（OSCC）在选定的ICPS中的患病率，包括范可尼贫血（FA）、Plummer-Vinson综合征、考登综合征、Li-Fraumeni综合征、先天性角化不良症和着色性干皮病，量化了风险程度，检查了诊断时的年龄，并评估了烟草对这些人群中OSCC风险的调节作用。研究设计：我们使用TriNetX研究网络进行了一项回顾性队列研究，包括20年期间由ICD - 10代码确定的患有或不患有ICPS的患者。OSCC病例按年龄和性别与对照组1:1匹配。分析评估了患病率、优势比、诊断年龄和烟草使用的影响。差异有统计学意义，P < 0.05。结果：ICPS患者中OSCC患病率为0.11% ~ 4.66%，以FA患者最高。在ICPS中，只有FA显著增加了OSCC的风险（OR = 40.63, P < 0.01），而Plummer-Vinson综合征与先天性角化不良呈负相关。ICPS患者发生OSCC的年龄更小（P < 0.0001）。吸烟增加了ICPS患者的OSCC风险（OR = 1.47），而不吸烟的ICPS患者的风险降低（OR = 0.78）。结论：FA与OSCC密切相关；OSCC也见于Li-Fraumeni综合征和Cowden综合征。ICPS患者在较年轻时出现OSCC，支持对高危ICPS人群进行有针对性的筛查。

{"title":"Oral squamous cell carcinoma risk and magnitude of association in inherited cancer predisposition syndromes: evidence from a large real-world cohort.","authors":"Stella O Oyewole, Adetokunbo B Olawuyi, Osariemen Okhuaihesuyi, Adepitan A Owosho","doi":"10.1016/j.oooo.2025.11.010","DOIUrl":"10.1016/j.oooo.2025.11.010","url":null,"abstract":"<p><strong>Objective: </strong>Inherited cancer predisposition syndromes (ICPS) are rare genetic disorders associated with an elevated cancer risk. This study evaluates oral squamous cell carcinoma (OSCC) prevalence across selected ICPS, including Fanconi anemia (FA), Plummer-Vinson syndrome, Cowden syndrome, Li-Fraumeni syndrome, dyskeratosis congenita, and xeroderma pigmentosum, quantifies risk magnitude, examines age at diagnosis, and assesses tobacco's modifying effect on OSCC risk in these populations.</p><p><strong>Study design: </strong>We conducted a retrospective cohort study using the TriNetX Research Network, including patients with or without ICPS identified by ICD‑10 codes over a 20‑year period. OSCC cases were matched 1:1 by age and sex to controls. The analyses assessed prevalence, odds ratios, age at diagnosis, and the impact of tobacco use. Statistical significance was set at P < .05.</p><p><strong>Results: </strong>The prevalence of OSCC among ICPS patients ranged from 0.11% to 4.66%, with the highest in patients with FA. Among ICPS, only FA showed a markedly increased OSCC risk (OR = 40.63, P < .01), while Plummer-Vinson syndrome and dyskeratosis congenita were inversely associated. Patients with ICPS developed OSCC at younger ages (P < .0001). Smoking increased OSCC risk within ICPS (OR = 1.47), whereas nonsmokers with ICPS had a reduced risk (OR = 0.78).</p><p><strong>Conclusions: </strong>FA is strongly associated with OSCC; OSCC also occurs in Li-Fraumeni syndrome and Cowden syndrome. Patients with ICPS present with OSCC at a younger age, supporting targeted screening for high‑risk ICPS populations.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-reported race and ethnicity in relation to oral potentially malignant disorders and oral cancer. 自我报告的种族和民族与口腔潜在恶性疾病和口腔癌的关系。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-19 DOI: 10.1016/j.oooo.2025.11.006

Adriana Mendonca da Silva, Polyanna Oliveira, Mariana Bezamat Chappel, Alexandre Rezende Vieira

Objective: To investigate the association between self-reported race and ethnicity with oral potentially malignant disorders and oral cancer, considering environmental and genetic influences.

Study design: This was a case-control study including clinical information and DNA samples from 792 subjects from the University of Pittsburgh dental clinics. The cases were 264 subjects diagnosed with oral potential malignant disorders or oral squamous cell carcinoma. Controls were matched by sex and age in a 1:2 ratio. χ² tests detected differences between groups regarding ethnicity, race, and covariates. A Post-hoc test with Bonferroni and Holm corrections accounted for multiple comparisons between groups. A standard χ² residual test was used to investigate which ethnicity category contributed most to the association. Multiple logistic regression models were used to obtain the unadjusted and adjusted odds ratios (ORs) and to detect the association between single-nucleotide variants and outcomes, stratified by ethnicity and race.

Results: The risk of having the outcomes was 78% greater in those patients who self-reported as African American (OR, 1.78; P = .002; 95% confidence interval, 1.225-2.592). Minor allele G (rs9879992-GSK3B) increased the risk for the outcomes in patients who self-reported as African American (OR, 1.85; P = .002; 95% confidence interval, 1.236-2.772).

Conclusions: Self-reported race and ethnicity were associated with oral potential malignant disorder/oral cancer. Future studies using ancestry informative markers can confirm these findings.

目的：在考虑环境和遗传影响的情况下，探讨自我报告的种族和民族与口腔潜在恶性疾病和口腔癌的关系。研究设计：这是一项病例对照研究，包括来自匹兹堡大学牙科诊所的792名受试者的临床信息和DNA样本。264例被诊断为口腔潜在恶性疾病或口腔鳞状细胞癌的患者。对照组按性别和年龄按1:2的比例配对。χ2检验检测各组在民族、种族和协变量方面的差异。采用Bonferroni和Holm校正的事后检验解释了组间的多重比较。采用标准χ2残差检验来调查哪个种族类别对相关性贡献最大。采用多元逻辑回归模型获得未调整和调整后的优势比（or），并检测单核苷酸变异与结果之间的关联，并按种族和种族分层。结果：自我报告为非裔美国人的患者出现上述结果的风险高出78% （OR, 1.78; P = 0.002； 95%可信区间，1.225-2.592）。小等位基因G （rs9879992-GSK3B）增加了自我报告为非洲裔美国人的预后风险（OR, 1.85; P = 0.002； 95%可信区间，1.236-2.772）。结论：自我报告的种族和民族与口腔潜在恶性疾病/口腔癌相关。未来使用祖先信息标记的研究可以证实这些发现。

{"title":"Self-reported race and ethnicity in relation to oral potentially malignant disorders and oral cancer.","authors":"Adriana Mendonca da Silva, Polyanna Oliveira, Mariana Bezamat Chappel, Alexandre Rezende Vieira","doi":"10.1016/j.oooo.2025.11.006","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.11.006","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between self-reported race and ethnicity with oral potentially malignant disorders and oral cancer, considering environmental and genetic influences.</p><p><strong>Study design: </strong>This was a case-control study including clinical information and DNA samples from 792 subjects from the University of Pittsburgh dental clinics. The cases were 264 subjects diagnosed with oral potential malignant disorders or oral squamous cell carcinoma. Controls were matched by sex and age in a 1:2 ratio. χ<sup>2</sup> tests detected differences between groups regarding ethnicity, race, and covariates. A Post-hoc test with Bonferroni and Holm corrections accounted for multiple comparisons between groups. A standard χ<sup>2</sup> residual test was used to investigate which ethnicity category contributed most to the association. Multiple logistic regression models were used to obtain the unadjusted and adjusted odds ratios (ORs) and to detect the association between single-nucleotide variants and outcomes, stratified by ethnicity and race.</p><p><strong>Results: </strong>The risk of having the outcomes was 78% greater in those patients who self-reported as African American (OR, 1.78; P = .002; 95% confidence interval, 1.225-2.592). Minor allele G (rs9879992-GSK3B) increased the risk for the outcomes in patients who self-reported as African American (OR, 1.85; P = .002; 95% confidence interval, 1.236-2.772).</p><p><strong>Conclusions: </strong>Self-reported race and ethnicity were associated with oral potential malignant disorder/oral cancer. Future studies using ancestry informative markers can confirm these findings.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic significance of MMP-14 in oral squamous cell carcinoma: insights from a Colombian cohort. MMP-14在口腔鳞状细胞癌中的预后意义：来自哥伦比亚队列的见解。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-19 DOI: 10.1016/j.oooo.2025.11.007

Yeimy Valentina Castañeda Rojas, Sergio D Cruz-Romero, Ana Margarita Baldión, José Antonio Hakim Tawil, Paula A Rodriguez-Urrego, Paula Alejandra Baldión

Introduction: Matrix metalloproteinase 14 (MMP-14) is crucial in extracellular matrix remodeling and tumor progression. This study evaluated MMP-14 expression in oral squamous cell carcinoma (OSCC) and its correlations with clinical, histopathological, and sociodemographic factors.

Methods: Manual tissue microarrays were constructed from 39 OSCC and 22 healthy mucosa samples from a Colombian cohort (2015-2022). MMP-14 detection was performed via immunohistochemistry using a combined histological score. Nonparametric tests and ROC analysis assessed their prognostic value.

Results: MMP-14 was significantly overexpressed in OSCC relative to healthy mucosa (P < .05), with cytoplasmic and membranous localization. Elevated levels were observed in patients aged ≥50 (P = .05), in cases with perineural invasion (P = .01), and in tongue tumors (P = .03). ROC analysis yielded an area under the curve of 0.90, indicating diagnostic potential.

Conclusions: The findings confirm MMP-14 overexpression in OSCC and its association with perineural invasion, underscoring its role in tumor progression. No significant correlations were found with lymph node metastasis, clinical stage, or histological grade. Limitations include MMP-14's ubiquitous expression, reducing biomarker specificity. Further research incorporating additional molecular markers is warranted to refine prognostic accuracy.

基质金属蛋白酶14 （MMP-14）在细胞外基质重塑和肿瘤进展中起着至关重要的作用。本研究评估了口腔鳞状细胞癌（OSCC）中MMP-14的表达及其与临床、组织病理学和社会人口学因素的相关性。方法：对来自哥伦比亚队列（2015-2022）的39份OSCC和22份健康粘膜样本构建人工组织微阵列。MMP-14检测通过免疫组织化学使用联合组织学评分。非参数检验和ROC分析评估其预后价值。结果：与健康粘膜相比，MMP-14在OSCC中显著过表达（P < 0.05），并有胞质和膜质定位。≥50岁患者（P = 0.05）、神经周围侵犯患者（P = 0.01）和舌肿瘤患者（P = 0.03）血清中血清素水平均升高。ROC分析显示曲线下面积为0.90，显示诊断潜力。结论：研究结果证实了MMP-14在OSCC中的过表达及其与神经周围侵袭的关联，强调了其在肿瘤进展中的作用。未发现与淋巴结转移、临床分期或组织学分级有显著相关性。限制包括MMP-14的普遍表达，降低了生物标志物的特异性。进一步的研究纳入额外的分子标记是必要的，以提高预后的准确性。

{"title":"Prognostic significance of MMP-14 in oral squamous cell carcinoma: insights from a Colombian cohort.","authors":"Yeimy Valentina Castañeda Rojas, Sergio D Cruz-Romero, Ana Margarita Baldión, José Antonio Hakim Tawil, Paula A Rodriguez-Urrego, Paula Alejandra Baldión","doi":"10.1016/j.oooo.2025.11.007","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.11.007","url":null,"abstract":"<p><strong>Introduction: </strong>Matrix metalloproteinase 14 (MMP-14) is crucial in extracellular matrix remodeling and tumor progression. This study evaluated MMP-14 expression in oral squamous cell carcinoma (OSCC) and its correlations with clinical, histopathological, and sociodemographic factors.</p><p><strong>Methods: </strong>Manual tissue microarrays were constructed from 39 OSCC and 22 healthy mucosa samples from a Colombian cohort (2015-2022). MMP-14 detection was performed via immunohistochemistry using a combined histological score. Nonparametric tests and ROC analysis assessed their prognostic value.</p><p><strong>Results: </strong>MMP-14 was significantly overexpressed in OSCC relative to healthy mucosa (P < .05), with cytoplasmic and membranous localization. Elevated levels were observed in patients aged ≥50 (P = .05), in cases with perineural invasion (P = .01), and in tongue tumors (P = .03). ROC analysis yielded an area under the curve of 0.90, indicating diagnostic potential.</p><p><strong>Conclusions: </strong>The findings confirm MMP-14 overexpression in OSCC and its association with perineural invasion, underscoring its role in tumor progression. No significant correlations were found with lymph node metastasis, clinical stage, or histological grade. Limitations include MMP-14's ubiquitous expression, reducing biomarker specificity. Further research incorporating additional molecular markers is warranted to refine prognostic accuracy.</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-articular therapies for synovial joint dysfunction: a comprehensive integrative review. 关节内治疗滑膜关节功能障碍：一项综合综述。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-15 DOI: 10.1016/j.oooo.2025.10.026

Leonardo Brigido Metello Neves, Bernardo Correia Lima, Rafael Coutinho de Mello, Bruno Luiz Baldessarini, Rafael Vidal Peres

Objective: To summarize contemporary evidence for intra-articular therapies in synovial joint dysfunction-emphasizing temporomandibular joint (TMJ) osteoarthritis-across regenerative (platelet-rich plasma [PRP]/ injectable platelet-rich fibrin [i-PRF], mesenchymal stem cells), lubricating (hyaluronic acid [HA]), anti-inflammatory (corticosteroids), and selected adjunctive/combination approaches.

Study design: An integrative narrative review (2020-2025) was performed of randomized trials, systematic reviews/meta-analyses, and high-quality mechanistic/preclinical studies (PubMed/Scopus/Web of Science/SciELO; English/Portuguese/Spanish). Quality considerations followed Preferred Reporting Items for Systematic reviews and Meta-Analyses guidance, Mixed Methods Appraisal Tool, and Cochrane/risk of bias paradigms; TMJ-specific data were prioritized with biologically justified extrapolation from other synovial joints.

Results: Mesenchymal stem cells yield visual analog scale reductions ≈30%-50% and Western Ontario and McMaster Universities Arthritis Index gains ≈20%-40% with reassuring 2-year safety and synergy when paired with HA/PRP. PRP improves symptoms ≈3-6 months but is preparation-sensitive; i-PRF's fibrin matrix sustains bioactive release (7-14 days), shifts synovial cytokines (interleukin [IL]-1β ↓58%, IL-6 ↓63%, IL-17 ↓51%, IL-10 ↑3-5×), and is associated with magnetic resonance imaging chondral preservation and larger clinical effects in TMJ/temporomandibular disorders. HA (especially high-molecular weight or cross-linked, bacterial-derived) consistently reduces pain 25%-45% with outstanding safety. Corticosteroids offer 50%-70% short-term relief but carry dose-dependent chondrotoxicity. Adjuncts (botulinum toxin type A, dextrose, ozone) and combinations (i-PRF+HA/ozone) are promising.

Conclusions: Intra-articular therapy has advanced from palliation to mechanism-driven modulation. i-PRF and mesenchymal stem cells show the strongest disease-modifying signals; HA remains a safe backbone and carrier. Standardized preparation/ reporting and TMJ-focused randomized trials are priority needs. (Oral Surg Oral Med Oral Pathol Oral Radiol 2026;XXX:xxx-xxx).

目的：总结当前滑膜关节功能障碍突出的颞下颌关节（TMJ）骨关节炎的关节内治疗证据，包括再生（富血小板血浆[PRP]/可注射富血小板纤维蛋白[i-PRF]、间充质干细胞）、润滑（透明质酸[HA]）、抗炎（皮质类固醇）和选择的辅助/联合方法。研究设计：对随机试验、系统评价/荟萃分析和高质量的机制/临床前研究（PubMed/Scopus/Web of Science/SciELO；英语/葡萄牙语/西班牙语）进行综合叙述性回顾（2020-2025）。质量考虑遵循系统评价和荟萃分析指南、混合方法评估工具和Cochrane/偏倚风险范式的首选报告项目；tmj特异性数据优先考虑其他滑膜关节的生物学合理推断。结果：当与HA/PRP配对时，间充质干细胞使视觉模拟规模减少约30%-50%，西安大略省和麦克马斯特大学关节炎指数增加约20%-40%，具有可靠的2年安全性和协同作用。PRP改善症状≈3-6个月，但对制剂敏感；i-PRF纤维蛋白基质维持生物活性释放（7-14天），转移滑膜细胞因子（白介素[IL]-1β↓58%，IL-6↓63%,IL-17↓51%,IL-10↑3- 5x），并与磁共振成像软骨保存和TMJ/颞下颌疾病的较大临床效果相关。透明质酸（特别是高分子量或交联的细菌衍生的）持续减少25%-45%的疼痛，具有出色的安全性。皮质类固醇可提供50%-70%的短期缓解，但具有剂量依赖性的软骨毒性。辅助剂（A型肉毒杆菌毒素，葡萄糖，臭氧）和组合（i-PRF+HA/臭氧）是有希望的。结论：关节内治疗已经从缓解发展到机制驱动的调节。i-PRF和间充质干细胞表现出最强的疾病修饰信号；HA仍然是一个安全的骨干和载体。标准化的准备/报告和以颞下颌关节为重点的随机试验是优先需要。（口腔外科口腔医学口腔病理口腔放射醇2026；XXX: XXX - XXX）。

{"title":"Intra-articular therapies for synovial joint dysfunction: a comprehensive integrative review.","authors":"Leonardo Brigido Metello Neves, Bernardo Correia Lima, Rafael Coutinho de Mello, Bruno Luiz Baldessarini, Rafael Vidal Peres","doi":"10.1016/j.oooo.2025.10.026","DOIUrl":"https://doi.org/10.1016/j.oooo.2025.10.026","url":null,"abstract":"<p><strong>Objective: </strong>To summarize contemporary evidence for intra-articular therapies in synovial joint dysfunction-emphasizing temporomandibular joint (TMJ) osteoarthritis-across regenerative (platelet-rich plasma [PRP]/ injectable platelet-rich fibrin [i-PRF], mesenchymal stem cells), lubricating (hyaluronic acid [HA]), anti-inflammatory (corticosteroids), and selected adjunctive/combination approaches.</p><p><strong>Study design: </strong>An integrative narrative review (2020-2025) was performed of randomized trials, systematic reviews/meta-analyses, and high-quality mechanistic/preclinical studies (PubMed/Scopus/Web of Science/SciELO; English/Portuguese/Spanish). Quality considerations followed Preferred Reporting Items for Systematic reviews and Meta-Analyses guidance, Mixed Methods Appraisal Tool, and Cochrane/risk of bias paradigms; TMJ-specific data were prioritized with biologically justified extrapolation from other synovial joints.</p><p><strong>Results: </strong>Mesenchymal stem cells yield visual analog scale reductions ≈30%-50% and Western Ontario and McMaster Universities Arthritis Index gains ≈20%-40% with reassuring 2-year safety and synergy when paired with HA/PRP. PRP improves symptoms ≈3-6 months but is preparation-sensitive; i-PRF's fibrin matrix sustains bioactive release (7-14 days), shifts synovial cytokines (interleukin [IL]-1β ↓58%, IL-6 ↓63%, IL-17 ↓51%, IL-10 ↑3-5×), and is associated with magnetic resonance imaging chondral preservation and larger clinical effects in TMJ/temporomandibular disorders. HA (especially high-molecular weight or cross-linked, bacterial-derived) consistently reduces pain 25%-45% with outstanding safety. Corticosteroids offer 50%-70% short-term relief but carry dose-dependent chondrotoxicity. Adjuncts (botulinum toxin type A, dextrose, ozone) and combinations (i-PRF+HA/ozone) are promising.</p><p><strong>Conclusions: </strong>Intra-articular therapy has advanced from palliation to mechanism-driven modulation. i-PRF and mesenchymal stem cells show the strongest disease-modifying signals; HA remains a safe backbone and carrier. Standardized preparation/ reporting and TMJ-focused randomized trials are priority needs. (Oral Surg Oral Med Oral Pathol Oral Radiol 2026;XXX:xxx-xxx).</p>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence: why we need it and what it means for the future of oral medicine 人工智能：我们为什么需要它，它对口腔医学的未来意味着什么。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-15 DOI: 10.1016/j.oooo.2025.10.022

Jaisri R. Thoppay BDS, MBA, MS, DABOM, MHSA, EdD(c) , Andres Pinto DMD, MPH, MSCE, MBA

引用次数: 0

A surgeon with a fork, in a world of soup 在汤的世界里，一个拿着叉子的外科医生：给编辑的信。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-15 DOI: 10.1016/j.oooo.2025.07.020

Ömer Uranbey DDS, PhD

引用次数: 0

Probability, diagnostic reasoning, and the most likely diagnosis 概率，诊断推理，以及最可能的诊断。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-14 DOI: 10.1016/j.oooo.2025.10.025

Steven H. Yale, Halil Tekiner, Eileen S. Yale

引用次数: 0

Reply to Letter to Editor: Probabilistic diagnostic thresholds 概率诊断阈值。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-14 DOI: 10.1016/j.oooo.2025.10.024

Michael Glick DMD, Alonso Carrasco-Labra DDS, MSc, PhD

引用次数: 0

Added value of the Alexandria preoperative imaging protocol combining noncontrast CT with MR sialography in sialolithiasis management 亚历山大术前影像学方案结合非对比CT和MR涎石造影在涎石症治疗中的价值。

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Pub Date : 2025-11-12 DOI: 10.1016/j.oooo.2025.10.023

Omneya Gamaleldin MD , Sarah S. Areif MS , Emad A. Magdy MD, PhD , Khaled M. Moghazy MD

Objective

To assess the added value of the Alexandria sialography imaging protocol of noncontrast computed tomography (NCCT) plus magnetic resonance (MR) sialography in the assessment of suspected sialolithiasis.

Study Design

This prospective study included 59 consecutive patients (37 males, 22 females; mean age, 35.7 years) presenting with acute or recurrent postprandial salivary gland swelling and colicky pain with suspected salivary calculi referred from March 2021 to May 2022 to a tertiary referral center. NCCT and MR sialography were done in all cases to detect sialolithiasis and provide detailed information about calculus size and location as well as ductal changes. Results were compared with subsequent operative sialendoscopy findings.

Results

NCCT provided 97.9% sensitivity and 83.3% specificity (P < 0.001*), while MR sialography had 79.6% sensitivity and 83.3% specificity (P = 0.003*). Combination of both NCCT and MR sialography gave higher sensitivity (97.9%) and specificity (100%) in stone detection (P < 0.001*). Details obtained regarding stone size, shape, number, and exact location in addition to ductal condition also provided an excellent road map for the surgeon before the procedure.

Conclusions

Combined NCCT plus MR sialography proved to be a valuable imaging protocol for preoperative planning of suspected sialolithiasis. It provided accurate assessment before surgery and, hence, facilitated minimally invasive salivary gland preservation.

目的：探讨非对比计算机断层扫描（NCCT）联合磁共振（MR）唾液造影在评估疑似唾液结石中的附加价值。研究设计：这项前瞻性研究纳入了59例连续患者（37名男性，22名女性，平均年龄35.7岁），这些患者在2021年3月至2022年5月期间出现急性或复发性餐后唾液腺肿胀和绞痛，并疑似唾液结石，他们被转诊到三级转诊中心。所有病例均进行了NCCT和MR唾液造影，以检测唾液结石，并提供有关结石大小、位置和导管变化的详细信息。结果比较了随后的手术鼻内镜检查结果。结果：NCCT的灵敏度为97.9%，特异性为83.3% (P < 0.001*)， MR唾液造影的灵敏度为79.6%，特异性为83.3% （P = 0.003*）。NCCT和MR唾液造影联合检测结石的灵敏度（97.9%）和特异性（100%）更高（P < 0.001*）。获得的有关结石大小、形状、数量和确切位置以及导管状况的详细信息也为外科医生在手术前提供了一个很好的路线图。结论：NCCT联合MR唾液造影被证明是一种有价值的影像学方案，用于术前计划疑似唾液结石。它在手术前提供了准确的评估，从而促进了微创涎腺保存。

{"title":"Added value of the Alexandria preoperative imaging protocol combining noncontrast CT with MR sialography in sialolithiasis management","authors":"Omneya Gamaleldin MD , Sarah S. Areif MS , Emad A. Magdy MD, PhD , Khaled M. Moghazy MD","doi":"10.1016/j.oooo.2025.10.023","DOIUrl":"10.1016/j.oooo.2025.10.023","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the added value of the Alexandria sialography imaging protocol of noncontrast computed tomography (NCCT) plus magnetic resonance (MR) sialography in the assessment of suspected sialolithiasis.</div></div><div><h3>Study Design</h3><div>This prospective study included 59 consecutive patients (37 males, 22 females; mean age, 35.7 years) presenting with acute or recurrent postprandial salivary gland swelling and colicky pain with suspected salivary calculi referred from March 2021 to May 2022 to a tertiary referral center. NCCT and MR sialography were done in all cases to detect sialolithiasis and provide detailed information about calculus size and location as well as ductal changes. Results were compared with subsequent operative sialendoscopy findings.</div></div><div><h3>Results</h3><div>NCCT provided 97.9% sensitivity and 83.3% specificity (<em>P</em> < 0.001*), while MR sialography had 79.6% sensitivity and 83.3% specificity (<em>P</em> = 0.003*). Combination of both NCCT and MR sialography gave higher sensitivity (97.9%) and specificity (100%) in stone detection (<em>P</em> < 0.001*). Details obtained regarding stone size, shape, number, and exact location in addition to ductal condition also provided an excellent road map for the surgeon before the procedure.</div></div><div><h3>Conclusions</h3><div>Combined NCCT plus MR sialography proved to be a valuable imaging protocol for preoperative planning of suspected sialolithiasis. It provided accurate assessment before surgery and, hence, facilitated minimally invasive salivary gland preservation.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"141 3","pages":"Pages 409-417"},"PeriodicalIF":1.9,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀