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Brazilian Society of Oral Medicine (Stomatology) and Oral & Maxillofacial Pathology: half-century of collaboration with the AAOM and the AAOMP. 巴西口腔医学(口腔科)和口腔颌面病理学学会:与 AAOM 和 AAOMP 合作半个世纪。
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-18 DOI: 10.1016/j.oooo.2024.09.005
Alan Roger Santos-Silva, Ana Carolina Prado Ribeiro, Thaís Cristina Esteves-Pereira, Luciana Estevam Simonato, Marcio Ajudarte Lopes, Pablo Agustin Vargas
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引用次数: 0
Prescription of potentially inappropriate medications in older adults; data from a dental institution. 老年人处方可能不当的药物;来自一家牙科机构的数据。
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-16 DOI: 10.1016/j.oooo.2024.09.006
Arwa Farag, Matthew Finkelman, Scarlet Charmelo-Silva, Christina Sun, Madison Mondry, Mohammed Bindakhil

Objectives: The objectives of this study were to determine the types and frequency of potentially inappropriate medications (PIMs) prescribed to geriatric patients while considering the patients' age groups and their American Society of Anesthesiologists (ASA) physical status.

Study design: We performed a 5-year retrospective chart review of patients aged 65 years and above who were seen in a dental institution. Patients' medical history, PIM prescriptions, and prescribers' specialty and professional status were analyzed.

Results: Out of 10,675 geriatric patients identified, 6.2% (n = 662) received PIM prescriptions. Of those, 77% received one PIM whereas the others (23%) received anywhere between 2 and 6; the majority (73.7%) of these 662 patients fell within an ASA III physical status. Nonsteroidal anti-inflammatory drugs (NSAIDs) were the most prescribed PIM (provided to 60.1% of subjects) followed by opioids (provided to 32.5% of subjects). Both NSAIDs and opioids were largely provided by providers in oral and maxillofacial surgery followed by those in restorative dentistry and periodontics. Benzodiazepines were mostly prescribed by endodontics providers, whereas tricyclic antidepressants, muscle relaxants, and anticonvulsants were mostly prescribed by oral medicine providers. Residents prescribed opioids at similar rates to the faculty (P = .78) but exceeded the faculty in prescribing benzodiazepines (P < .001).

Conclusion: PIMs were prescribed at low percentages to geriatric patients; however, most prescriptions were provided to patients classified with ASA III status. Further efforts are indicated, at institutional and national levels, to monitor/limit PIMs provided to geriatric population. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).

研究目的本研究的目的是确定为老年患者开具的潜在不适当药物(PIMs)的类型和频率,同时考虑患者的年龄组及其美国麻醉医师协会(ASA)的身体状况:我们对在一家牙科机构就诊的 65 岁及以上患者进行了为期 5 年的回顾性病历审查。我们对患者的病史、PIM 处方以及处方者的专业和职业状况进行了分析:在已确认的 10,675 名老年患者中,6.2%(n = 662)的患者接受过 PIM 处方。在这 662 名患者中,大多数(73.7%)属于 ASA III 身体状况。非甾体抗炎药(NSAIDs)是处方最多的 PIM(60.1% 的受试者使用),其次是阿片类药物(32.5% 的受试者使用)。非甾体抗炎药和阿片类药物主要由口腔颌面外科医疗人员提供,其次是牙科修复和牙周病学医疗人员。苯二氮卓类药物主要由牙髓病学医疗人员开具,而三环类抗抑郁药、肌肉松弛剂和抗惊厥药则主要由口腔内科医疗人员开具。住院医师处方阿片类药物的比例与教师相似(P = .78),但在处方苯二氮卓类药物方面超过了教师(P < .001):结论:给老年病人开具 PIMs 处方的比例较低;但大多数处方都提供给了 ASA III 级的病人。需要在机构和国家层面进一步努力,监控/限制向老年患者提供的 PIMs。(Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)。
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引用次数: 0
Intraosseous benign peripheral nerve sheath tumor of the jaws: report of 4 new cases and a comprehensive literature review. 颌骨内良性周围神经鞘瘤:4 个新病例的报告和全面的文献综述。
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-16 DOI: 10.1016/j.oooo.2024.09.004
Brendo Vinícius Rodrigues Louredo, Paulo Victor Mendes Penafort, Ana Luiza Oliveira Corrêa Roza, Maria Cecília Querido De Oliveira, Ricardo Pelletti Ocaña, Alexandre Machado Torres, Samuel de Barros Ferreira Júnior, André Caroli Rocha, Rafael Cabral da Costa, Fábio Ramoa Pires, José Divaldo Prado, Jacks Jorge-Júnior, Pablo Agustin Vargas

Benign peripheral nerve sheath tumors (BPNSTs) are a vast, common, heterogeneous group of lesions that are often diagnostically challenging. The head and neck region is recognized as the second most common location for these lesions, especially the tongue. However, BPNSTs occurring centrally within the jaw bones are exceedingly rare. To date, approximately 161 cases of intraosseous BPNSTs have been reported in the jaws. This group mainly includes the relatively more common neurofibromas and schwannomas, and the less common perineuriomas and hybrid forms. Unlike soft tissues, schwannomas are the most common BPNSTs occurring within the jaws, followed by neurofibromas and perineuriomas. These neoplasms can present as a well-defined unilocular lesion or as an ill-defined multilocular image, resembling several types of benign and malignant lesions of odontogenic origin. The aim of the current study was to report 4 new cases of intraosseous BPNSTs and a comprehensive literature review.

良性周围神经鞘瘤(BPNSTs)是一种广泛、常见的异质性病变,在诊断上往往具有挑战性。头颈部是这类病变的第二大常见部位,尤其是舌头。然而,发生在颌骨中心的 BPNST 却极为罕见。迄今为止,约有 161 例骨内 BPNST 发生在颌骨的报道。这类肿瘤主要包括相对较常见的神经纤维瘤和分裂瘤,以及较少见的会厌瘤和混合瘤。与软组织不同,分裂瘤是发生在颌骨内最常见的 BPNST,其次是神经纤维瘤和会厌瘤。这些肿瘤可表现为界限清楚的单发性病变,也可表现为界限不清的多发性病变,与几种牙源性良性和恶性病变相似。本研究旨在报告 4 例骨内 BPNSTs 新病例,并进行全面的文献综述。
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引用次数: 0
Spontaneous bacterial peritonitis and soft tissue healing after tooth extraction in liver cirrhosis patients. 肝硬化患者拔牙后的自发性细菌性腹膜炎和软组织愈合。
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-15 DOI: 10.1016/j.oooo.2024.09.003
Gustavo Souza Galvão, Juliana Bertoldi Franco, Maria Paula Siqueira de Melo Peres, Gabriela Bănacu Melo, Jefferson R Tenório, Janaina B Medina, Camila de Barros Gallo, Karem L Ortega

Objective: The objective of this study was to identify the association between tooth extraction and occurrence of spontaneous bacterial peritonitis (SBP) and to assess delayed soft tissue healing of extraction sockets in patients with cirrhosis.

Study design: One hundred nineteen participants awaiting liver transplantation who required tooth extraction were included. Seven days before the surgery, the patients underwent panoramic radiography and laboratory examinations. Soft tissue healing was evaluated 7 days after the tooth extraction and medical records were checked after 21 days for development of SBP. The relationship between predictive factors and outcomes was assessed by using multiple binomial logistic regression.

Results: One hundred ninety-five teeth were extracted, resulting in 146 alveolar wounds, in which the majority (47%) consisted of alveolar sockets of multirooted teeth. One participant was diagnosed with SBP (Escherichia coli [E. coli]) and another diagnosed with bacterascites (Streptococcus viridans [S. viridans] group), occurring 11 and 6 days after tooth extraction. Poor soft tissue healing was observed in 20 (13.7%) patients, which was correlated to 2 risk factors, that is, jaundice (P = .007, adjusted odds ratio [OR] = 4.91, 95% confidence interval [CI] = 1.56-15.47) and moderate neutropenia (P = .048, adjusted OR = 13.99, 95% CI = 1.02-192.07).

Conclusions: No association was found between tooth extraction and SBP in patients with cirrhosis. The delayed soft tissue healing was related to jaundice (hyperbilirubinemia) and moderate neutropenia.

研究目的本研究旨在确定肝硬化患者拔牙与自发性细菌性腹膜炎(SBP)发生之间的关联,并评估拔牙窝软组织延迟愈合的情况:研究设计:共纳入了 119 名需要拔牙的肝移植候诊者。手术前七天,患者接受全景放射摄影和实验室检查。拔牙后 7 天评估软组织愈合情况,21 天后检查病历以确定是否出现 SBP。采用多元二项式逻辑回归评估了预测因素与结果之间的关系:共拔除 195 颗牙齿,造成 146 处牙槽骨伤口,其中大部分(47%)为多根牙齿的牙槽骨伤口。一名受试者被诊断为 SBP(大肠杆菌),另一名受试者被诊断为菌斑(病毒性链球菌),分别发生在拔牙后 11 天和 6 天。20例(13.7%)患者的软组织愈合不良,这与两个风险因素有关,即黄疸(P = .007,调整后比值比 [OR] = 4.91,95% 置信区间 [CI] = 1.56-15.47)和中性粒细胞减少(P = .048,调整后比值比 [OR] = 13.99,95% 置信区间 [CI] = 1.02-192.07):结论:肝硬化患者拔牙与SBP之间没有关联。软组织愈合延迟与黄疸(高胆红素血症)和中性粒细胞减少症有关。
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引用次数: 0
Evaluation of postoperative peri-implant reactive tissues following implant supported prosthetic rehabilitation in fibula free flaps 评估腓骨游离瓣种植体支持修复术后种植体周围反应性组织的情况
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-31 DOI: 10.1016/j.oooo.2024.08.017
Samuel D. Raffaelli DDS , Timothy W. Neal DDS, MD , Jonathan J. Jelmini DDS, MD , Roderick Y. Kim DDS, MD, MBA, FACS , Fayette C. Williams DDS, MD, FACS

Objectives

The purpose of this study was to measure the frequency of peri-implant reactive tissue development in a cohort of patients following immediate implant supported prosthetic rehabilitation in fibula free flaps at our institution and to document 2 cases of management based on our institution's experience.

Study Design

To address this question of study design, a case series was performed from October 2014 to May 2022. We included patients that underwent a fibula free flap reconstruction of the mandible or maxilla with immediate implant placement and dental prostheses fabrication. Forty-four patients met the inclusion criteria, and, among the participants, a total of 26 male patients (59%) and 18 female patients (41%) were evaluated, with 185 implants placed all together.

Results

Twenty patients (45%) were treated for benign pathology, 12 with malignant pathology (27%), 5 with trauma (11%), and 7 with osteoradionecrosis (16%). Postoperative peri-implant reactive tissues were seen to develop at 39 of the implant sites (21%).

Conclusion

Reactive tissues were found to be a common complication in patients treated with fibular free flap reconstructions involving implant rehabilitation. Our institution noted that local excision of such reactive tissues, in addition to silver nitrate cauterization and topical steroid application, may provide reasonable success in dealing with these occurrences. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range)
本研究的目的是测量在本机构接受腓骨游离瓣即刻种植支持修复术的患者群中种植体周围反应性组织发生的频率,并根据本机构的经验记录2个处理病例。为了解决这一研究设计问题,我们在 2014 年 10 月至 2022 年 5 月期间进行了一项病例系列研究。我们纳入了接受下颌或上颌腓骨游离瓣重建术并立即植入种植体和制作义齿的患者。有 44 名患者符合纳入标准,其中共有 26 名男性患者(59%)和 18 名女性患者(41%)接受了评估,共植入了 185 个种植体。其中,20 名患者(45%)因良性病变接受治疗,12 名患者(27%)因恶性病变接受治疗,5 名患者(11%)因外伤接受治疗,7 名患者(16%)因骨坏死接受治疗。术后有 39 个种植部位(21%)出现了种植体周围反应性组织。反应性组织是腓骨游离瓣重建术患者常见的并发症之一。我院指出,除了硝酸银烧灼和局部应用类固醇外,局部切除此类反应性组织也可成功解决这些问题。(口腔外科口腔医学口腔病理学口腔放射年;卷:页码范围)。
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引用次数: 0
Digoxin attenuates bisphosphonate related osteonecrosis of the jaws by RORγt-dependent Th17 response in male rats 地高辛通过 RORγt 依赖性 Th17 反应减轻雄性大鼠与双膦酸盐相关的颌骨坏死症
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-31 DOI: 10.1016/j.oooo.2024.08.013
José Vitor Mota Lemos MS , Joyce Ohana de Lima Martins MS , Larissa Carvalho Machado DDS , Lara Rabelo Aragão MS , Maria Elisa Quezado Lima Verde PhD , Cláudia do Ó. Pessoa PhD , Maria Júlia Barbosa Bezerra PhD , Ana Paula Negreiros Nunes Alves PhD , Paulo Goberlânio de Barros Silva PhD

Objective

The study aimed to evaluate digoxin, an RORγt inhibitor, in Medication-Related Osteonecrosis of the Jaws (MRONJ) in male rats treated with zoledronic acid (ZA).

Study Design

Forty male Wistar rats were divided into a negative control group (0.1 mL/kg saline), a positive control group (ZA, 0.20 mg/kg), and three test groups treated with ZA and digoxin at 1 (DG1), 2 (DG2), or 4 (DG4) mg/kg. These groups received treatment three times weekly. ZA was administered intravenously on days 0, 7, and 14, followed by extraction of the left lower first molar on day 42, a final ZA dose on day 49, and euthanasia on day 70. Analyses included radiographic, histomorphometric, and immunohistochemical evaluation of the mandibles, western blotting of gingiva, and mechanical tests on femurs. Statistical analysis was performed using ANOVA/Bonferroni tests (P < .05).

Results

Digoxin reduced radiolucency of MRONJ (P < .001), inflammatory cells, empty osteocyte lacunae (P < .001), apoptotic osteoclasts (P < .001), and Caspase-3-positive osteocytes (P = .021). ZA increased immunoreactivity for most markers except c-Fos, while digoxin reduced interleukin 17, TNF-α, IL-6, IL-2, FOXP3, c-Jun, NFκB (P < .001), TGF-β (P = .009), RANKL (P = .035), and OPG (P = .034). Digoxin also reversed RORγt expression (P < .001), increased diarrhea scores (P = .028), renal and cardiac indexes (P < .001), and enhanced femur mechanical properties (P < .013).

Conclusions

Digoxin attenuated MRONJ by inhibiting RORγt and reducing the Th17 response.
该研究旨在评估地高辛(一种RORγt抑制剂)对唑来膦酸(ZA)治疗雄性大鼠药物相关性颌骨坏死(MRONJ)的影响。40 只雄性 Wistar 大鼠被分为阴性对照组(0.1 毫升/千克生理盐水)、阳性对照组(ZA,0.20 毫克/千克)和三个试验组,试验组分别使用 1(DG1)、2(DG2)或 4(DG4)毫克/千克的ZA和地高辛进行治疗。这些试验组每周接受三次治疗。第0、7和14天静脉注射ZA,第42天拔除左下第一臼齿,第49天注射最后一次ZA,第70天安乐死。分析包括下颌骨的放射学、组织形态学和免疫组化评估、牙龈的印迹分析以及股骨的机械测试。统计分析采用方差分析/邦费罗尼检验(< .05)。地高辛减少了MRONJ的放射性透明(< .001)、炎症细胞、空骨细胞裂隙(< .001)、凋亡的破骨细胞(< .001)和Caspase-3阳性的骨细胞(= .021)。ZA增加了除c-Fos以外的大多数标记物的免疫活性,而地高辛则降低了白细胞介素17、TNF-α、IL-6、IL-2、FOXP3、c-Jun、NFκB(< .001)、TGF-β(= .009)、RANKL(= .035)和OPG(= .034)。地高辛还逆转了RORγt的表达(< .001),提高了腹泻评分(= .028)、肾脏和心脏指数(< .001),并增强了股骨的机械性能(< .013)。地高辛通过抑制RORγt和减少Th17反应减轻了MRONJ。
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引用次数: 0
Society Page 社会网页
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-27 DOI: 10.1016/S2212-4403(24)00418-8
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引用次数: 0
Information for Readers 读者信息
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-27 DOI: 10.1016/S2212-4403(24)00419-X
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引用次数: 0
Letter to the editor regarding “Surgical management of naso-orbito-ethmoidal fractures: a systematic review” 致编辑的信,内容涉及 "鼻眶外侧骨折的手术治疗:系统综述
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-23 DOI: 10.1016/j.oooo.2024.07.015
Naji Naseef Pathoor MSc, Rajesh Kanna Gopal MPhil, PhD, Pitchaipillai Sankar Ganesh MPhil, PhD
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引用次数: 0
Differences in BRAF V600E mutation between the epithelium and mesenchyme in classic ameloblastoma 典型骨髓母细胞瘤上皮细胞和间充质的 BRAF V600E 突变差异
IF 2 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-21 DOI: 10.1016/j.oooo.2024.08.001
Zhuoxuan Chen MD , Yingying Hong PhD , Zhenni Zhao MD , Ningxiang Wu MD , Xiaokun Ma MD , Linlin Chen PhD , Ran Zhang PhD

Objective

Laser capture microdissection (LCM) was used to pinpoint the mutated tissue in ameloblastoma and investigate whether B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation is the main pathogenic gene in classic ameloblastoma.

Study Design

A total of 24 patients with ameloblastoma scheduled to undergo surgery between 2000 and 2024 were included in the study. LCM was used to isolate tumor cells. Oxford nanopore technology (ONT) was used to analyze the collected cells. GO and KEGG enrichment analyses were then performed on the 300 most highly expressed genes in the epithelial tissue and mesenchyme.

Results

Mandibular follicular ameloblastoma showed BRAF V600E mutations in all epithelial cells but not in the mesenchyme. The mutation rate was significantly higher in mandibular ameloblastomas compared to the maxilla (P < .05). RNA-seq showed that traditional follicular ameloblastoma epithelium was enriched in “growth factor receptor binding” and “angiogenesis regulation,” while the mesenchyme was enriched in “ECM receptor interaction.” KEGG enrichment analysis showed differential gene expression, mainly in MAPK and PI3K-AKT pathways.

Conclusion

Classical follicular ameloblastoma shows the presence of BRAF V600E mutation in epithelial tissue, with a higher mutation rate in the mandible than in the maxilla. The signaling pathways of MAPK and PI3K may be significantly involved in epithelial signal transduction.
研究人员利用激光捕获显微切割技术(LCM)精确定位母细胞瘤中的突变组织,并研究B-Raf原癌基因(丝氨酸/苏氨酸激酶)突变是否是典型母细胞瘤的主要致病基因。研究共纳入了 24 名计划在 2000 年至 2024 年期间接受手术的牙釉质母细胞瘤患者。采用 LCM 分离肿瘤细胞。牛津纳米孔技术(ONT)用于分析收集到的细胞。然后对上皮组织和间质中表达量最高的 300 个基因进行 GO 和 KEGG 富集分析。下颌滤泡性母细胞瘤的所有上皮细胞都出现了V600E突变,但间质中没有。与上颌骨相比,下颌毛囊性母细胞瘤的突变率明显更高(< .05)。RNA-seq显示,传统的滤泡性母细胞瘤上皮细胞富集于 "生长因子受体结合 "和 "血管生成调节",而间质细胞富集于 "ECM受体相互作用"。KEGG富集分析表明基因表达存在差异,主要集中在MAPK和PI3K-AKT通路。典型的滤泡性母细胞瘤显示上皮组织存在V600E突变,下颌骨的突变率高于上颌骨。MAPK和PI3K的信号通路可能在上皮信号转导中起重要作用。
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引用次数: 0
期刊
Oral Surgery Oral Medicine Oral Pathology Oral Radiology
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