Pub Date : 2025-01-01DOI: 10.1016/j.dcn.2024.101491
ET. Marcelle , H. Yang , JW. Cohen , B. Ramphal , D. Pagliaccio , V. Rauh , BS. Peterson , F. Perera , H. Andrews , AG. Rundle , J. Herbstman , AE. Margolis
A left-lateralized cortical reading circuit underlies successful reading and fails to engage in individuals with reading problems. Studies identifying this circuit included youth from economically advantaged backgrounds and focused on cortical, not subcortical, structures. However, among youth with low scores on reading tests who are living in the context of economic disadvantage, this brain network is actively engaged during reading, despite persistent reading problems. This finding suggests that other brain circuits may underlie reading in these youth. A hippocampal circuit is one likely candidate, as it has recently been shown to support domain-general processes like working memory (WM) that are also associated with reading. Given age-related increases in hippocampal volume, WM, and reading, and known associations between WM and reading, we hypothesized that hippocampal volume would be associated with reading via WM processes. Using a cross-sectional developmental design, we explored this in middle childhood (average age at MRI scan ∼10; N = 50) and adolescence (average age at MRI scan ∼17; N = 175). Results suggest that the hippocampus is a critical contributor to word reading in adolescents living in economically disadvantaged contexts, and that this operates through working memory processes. Such findings point to new targets for reading intervention in adolescents.
{"title":"The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage","authors":"ET. Marcelle , H. Yang , JW. Cohen , B. Ramphal , D. Pagliaccio , V. Rauh , BS. Peterson , F. Perera , H. Andrews , AG. Rundle , J. Herbstman , AE. Margolis","doi":"10.1016/j.dcn.2024.101491","DOIUrl":"10.1016/j.dcn.2024.101491","url":null,"abstract":"<div><div>A left-lateralized cortical reading circuit underlies successful reading and fails to engage in individuals with reading problems. Studies identifying this circuit included youth from economically advantaged backgrounds and focused on cortical, not subcortical, structures. However, among youth with low scores on reading tests who are living in the context of economic disadvantage, this brain network is actively engaged during reading, despite persistent reading problems. This finding suggests that other brain circuits may underlie reading in these youth. A hippocampal circuit is one likely candidate, as it has recently been shown to support domain-general processes like working memory (WM) that are also associated with reading. Given age-related increases in hippocampal volume, WM, and reading, and known associations between WM and reading, we hypothesized that hippocampal volume would be associated with reading via WM processes. Using a cross-sectional developmental design, we explored this in middle childhood (average age at MRI scan ∼10; N = 50) and adolescence (average age at MRI scan ∼17; N = 175). Results suggest that the hippocampus is a critical contributor to word reading in adolescents living in economically disadvantaged contexts, and that this operates through working memory processes. Such findings point to new targets for reading intervention in adolescents.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"Article 101491"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.dcn.2024.101492
Fu-Miao Tan , Junhong Yu , Alicia M. Goodwill
Various psychosocial factors like collaboration inherent to team sports might provide a more dynamic environment for cognitive challenges that could foster enhanced neurocognitive development compared to individual sports. We investigated the impact of different organised sports on neurocognitive development in children (N = 11,878; aged 9–11) from the Adolescent Brain Cognitive Development (ABCD) study. Participants were classified into four categories based on their sports involvement at baseline and two years later: none, individual-based, team-based, or both. Cross-sectional and longitudinal analyses were conducted on 11 cognitive tests and neuroimaging metrics (i.e., resting-state functional connectivity and various grey matter (GM) and white matter (WM) measurements) between sport groups. A comparison between team and individual sports yielded no significant differences in cognitive measures at baseline and follow-up. Similarly, although WM microstructural differences were significant, the effect size was small. However, participation in any sport at baseline was associated with superior performance in various cognitive domains (i.e. inhibition, processing speed, and others), greater subcortical GM volume (i.e. cerebellum cortex, amygdala, hippocampus, and others), and whole-brain WM integrity compared to non-participants. Results suggest a positive association between organised sports participation, specifically individual and team-based sports, and neurocognitive development. However, further investigation is warranted to determine the nuanced effects of different sports on neurocognitive development.
{"title":"Sports participation & childhood neurocognitive development","authors":"Fu-Miao Tan , Junhong Yu , Alicia M. Goodwill","doi":"10.1016/j.dcn.2024.101492","DOIUrl":"10.1016/j.dcn.2024.101492","url":null,"abstract":"<div><div>Various psychosocial factors like collaboration inherent to team sports might provide a more dynamic environment for cognitive challenges that could foster enhanced neurocognitive development compared to individual sports. We investigated the impact of different organised sports on neurocognitive development in children (N = 11,878; aged 9–11) from the Adolescent Brain Cognitive Development (ABCD) study. Participants were classified into four categories based on their sports involvement at baseline and two years later: none, individual-based, team-based, or both. Cross-sectional and longitudinal analyses were conducted on 11 cognitive tests and neuroimaging metrics (i.e., resting-state functional connectivity and various grey matter (GM) and white matter (WM) measurements) between sport groups. A comparison between team and individual sports yielded no significant differences in cognitive measures at baseline and follow-up. Similarly, although WM microstructural differences were significant, the effect size was small. However, participation in any sport at baseline was associated with superior performance in various cognitive domains (i.e. inhibition, processing speed, and others), greater subcortical GM volume (i.e. cerebellum cortex, amygdala, hippocampus, and others), and whole-brain WM integrity compared to non-participants. Results suggest a positive association between organised sports participation, specifically individual and team-based sports, and neurocognitive development. However, further investigation is warranted to determine the nuanced effects of different sports on neurocognitive development.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"Article 101492"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.dcn.2025.101507
Giorgia Picci , Nathan M. Petro , Chloe C. Casagrande , Lauren R. Ott , Hannah J. Okelberry , Danielle L. Rice , Anna T. Coutant , Grace C. Ende , Erica L. Steiner , Yu-Ping Wang , Julia M. Stephen , Vince D. Calhoun , Tony W. Wilson
The pituitary gland (PG) plays a central role in the production and secretion of pubertal hormones, with documented links to the increase in mental health symptoms during adolescence. Although literature has largely focused on examining whole PG volume, recent findings have demonstrated associations among pubertal hormone levels, including dehydroepiandrosterone (DHEA), PG subregions, and mental health symptoms during adolescence. Despite the anterior PG’s role in DHEA production, studies have not yet examined potential links with transdiagnostic symptomology (i.e., dysregulation) pertinent to long-term functioning. Therefore, the current study sought examine whether anterior PG volume mediates associations between DHEA levels and changes in dysregulation symptoms in an adolescent sample (N = 114, 9 –17 years, Mage = 12.87, SD = 1.88). Following manual tracing, structural equation modeling revealed that greater anterior, not posterior, PG volume mediated the association between greater DHEA levels and increasing dysregulation symptoms across time, controlling for baseline dysregulation symptom levels. Results also showed that greater DHEA levels related to decreasing symptoms across time, suggesting potential attenuation effects. Altogether, these results provide support for separating the anterior and posterior PG by demonstrating specificity in the role of the anterior PG in adrenarcheal processes that may confer risk for adolescent psychopathology.
{"title":"Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth","authors":"Giorgia Picci , Nathan M. Petro , Chloe C. Casagrande , Lauren R. Ott , Hannah J. Okelberry , Danielle L. Rice , Anna T. Coutant , Grace C. Ende , Erica L. Steiner , Yu-Ping Wang , Julia M. Stephen , Vince D. Calhoun , Tony W. Wilson","doi":"10.1016/j.dcn.2025.101507","DOIUrl":"10.1016/j.dcn.2025.101507","url":null,"abstract":"<div><div>The pituitary gland (PG) plays a central role in the production and secretion of pubertal hormones, with documented links to the increase in mental health symptoms during adolescence. Although literature has largely focused on examining whole PG volume, recent findings have demonstrated associations among pubertal hormone levels, including dehydroepiandrosterone (DHEA), PG subregions, and mental health symptoms during adolescence. Despite the anterior PG’s role in DHEA production, studies have not yet examined potential links with transdiagnostic symptomology (i.e., dysregulation) pertinent to long-term functioning. Therefore, the current study sought examine whether anterior PG volume mediates associations between DHEA levels and changes in dysregulation symptoms in an adolescent sample (<em>N</em> = 114, 9 –17 years, M<sub>age</sub> = 12.87, SD = 1.88). Following manual tracing, structural equation modeling revealed that greater anterior, not posterior, PG volume mediated the association between greater DHEA levels and increasing dysregulation symptoms across time, controlling for baseline dysregulation symptom levels. Results also showed that greater DHEA levels related to decreasing symptoms across time, suggesting potential attenuation effects. Altogether, these results provide support for separating the anterior and posterior PG by demonstrating specificity in the role of the anterior PG in adrenarcheal processes that may confer risk for adolescent psychopathology.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"Article 101507"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-22DOI: 10.1016/j.dcn.2024.101498
Amanda Boyes , Jacob M. Levenstein , Larisa T. McLoughlin , Christina Driver , Dashiell D. Sacks , Kassie Bromley , Taliah Prince , Justine M. Gatt , Jim Lagopoulos , Daniel F. Hermens
This temporally rich, longitudinal study of early adolescents (N = 88, 277 datasets, 12–13 years) investigated the relationship between bilateral subcortical grey matter volume (GMV) in the hippocampus, amygdala, accumbens-area, caudate, putamen and pallidum with self-reported mental wellbeing at four timepoints, across 12 months. Generalised Estimating Equations (GEE) revealed (1) higher ‘total wellbeing’ was associated with smaller left caudate and larger left accumbens-area; (2) higher eudaimonic wellbeing was associated with smaller left caudate and larger right caudate; and (3) higher hedonic wellbeing was associated with larger left accumbens-area. Further analyses and plots highlighted different associations between GMV and wellbeing for adolescents who consistently experienced ‘moderate-to-flourishing’ wellbeing (n = 63, 201 datasets), compared with those who experienced ‘languishing’ wellbeing at any timepoint (n = 25, 76 datasets). These findings demonstrate several associations between subcortical GMV and measures of wellbeing, at short intervals in early adolescence. Taken together, sub-types of wellbeing appear uniquely associated with specific subcortical regions; and there may be a distinct neurobiological and wellbeing profile for adolescents who experience poorer wellbeing over the course of their first year(s) of secondary school. This study implicates the bilateral caudate and left accumbens-area as important targets for future research into the mental wellbeing of adolescents.
{"title":"Characterising mental wellbeing and associations with subcortical grey matter volume at short intervals in early adolescence","authors":"Amanda Boyes , Jacob M. Levenstein , Larisa T. McLoughlin , Christina Driver , Dashiell D. Sacks , Kassie Bromley , Taliah Prince , Justine M. Gatt , Jim Lagopoulos , Daniel F. Hermens","doi":"10.1016/j.dcn.2024.101498","DOIUrl":"10.1016/j.dcn.2024.101498","url":null,"abstract":"<div><div>This temporally rich, longitudinal study of early adolescents (N = 88, 277 datasets, 12–13 years) investigated the relationship between bilateral subcortical grey matter volume (GMV) in the hippocampus, amygdala, accumbens-area, caudate, putamen and pallidum with self-reported mental wellbeing at four timepoints, across 12 months. Generalised Estimating Equations (GEE) revealed (1) higher ‘total wellbeing’ was associated with smaller left caudate and larger left accumbens-area; (2) higher eudaimonic wellbeing was associated with smaller left caudate and larger right caudate; and (3) higher hedonic wellbeing was associated with larger left accumbens-area. Further analyses and plots highlighted different associations between GMV and wellbeing for adolescents who consistently experienced ‘moderate-to-flourishing’ wellbeing (n = 63, 201 datasets), compared with those who experienced ‘languishing’ wellbeing at any timepoint (n = 25, 76 datasets). These findings demonstrate several associations between subcortical GMV and measures of wellbeing, at short intervals in early adolescence. Taken together, sub-types of wellbeing appear uniquely associated with specific subcortical regions; and there may be a distinct neurobiological and wellbeing profile for adolescents who experience poorer wellbeing over the course of their first year(s) of secondary school. This study implicates the bilateral caudate and left accumbens-area as important targets for future research into the mental wellbeing of adolescents.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"72 ","pages":"Article 101498"},"PeriodicalIF":4.6,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-22DOI: 10.1016/j.dcn.2024.101479
Nathan M. Petro , Giorgia Picci , Lauren K. Webert , Mikki Schantell , Jake J. Son , Thomas W. Ward , Kellen M. McDonald , Cooper L. Livermore , Abraham D. Killanin , Danielle L. Rice , Grace C. Ende , Anna T. Coutant , Erica L. Steiner , Tony W. Wilson
Adolescence is a period of profound biopsychosocial development, with pubertally-driven neural reorganization as social demands increase in peer contexts. The explosive increase in social media access has fundamentally changed peer interactions among youth, creating an urgent need to understand its impact on neurobiological development and mental health. Extant literature indicates that using social media promotes social comparison and feedback seeking (SCFS) behaviors in youth, which portend increased risk for mental health disorders, but little is known about its impact on neurobiological development. We assessed social media behaviors, mental health symptoms, and spontaneous cortical activity using magnetoencephalography (MEG) in 80 typically developing youth (8–16 years) and tested how self-reported pubertal stage moderates their relationship. More mature adolescents who engaged in more SCFS showed weaker fusiform/parahippocampal alpha and medial prefrontal beta activity, and increased symptoms of anxiety and attention problems. Engaging in SCFS on social media during adolescence may thus relate to developmental differences in brain regions that undergo considerable development during puberty. These results are consistent with works indicating altered neurodevelopmental trajectories within association cortices surrounding the onset of many mental health disorders. Importantly, later pubertal stages may be most sensitive to the detrimental effects of social media use.
{"title":"Interactive effects of social media use and puberty on resting-state cortical activity and mental health symptoms","authors":"Nathan M. Petro , Giorgia Picci , Lauren K. Webert , Mikki Schantell , Jake J. Son , Thomas W. Ward , Kellen M. McDonald , Cooper L. Livermore , Abraham D. Killanin , Danielle L. Rice , Grace C. Ende , Anna T. Coutant , Erica L. Steiner , Tony W. Wilson","doi":"10.1016/j.dcn.2024.101479","DOIUrl":"10.1016/j.dcn.2024.101479","url":null,"abstract":"<div><div>Adolescence is a period of profound biopsychosocial development, with pubertally-driven neural reorganization as social demands increase in peer contexts. The explosive increase in social media access has fundamentally changed peer interactions among youth, creating an urgent need to understand its impact on neurobiological development and mental health. Extant literature indicates that using social media promotes social comparison and feedback seeking (SCFS) behaviors in youth, which portend increased risk for mental health disorders, but little is known about its impact on neurobiological development. We assessed social media behaviors, mental health symptoms, and spontaneous cortical activity using magnetoencephalography (MEG) in 80 typically developing youth (8–16 years) and tested how self-reported pubertal stage moderates their relationship. More mature adolescents who engaged in more SCFS showed weaker fusiform/parahippocampal alpha and medial prefrontal beta activity, and increased symptoms of anxiety and attention problems. Engaging in SCFS on social media during adolescence may thus relate to developmental differences in brain regions that undergo considerable development during puberty. These results are consistent with works indicating altered neurodevelopmental trajectories within association cortices surrounding the onset of many mental health disorders. Importantly, later pubertal stages may be most sensitive to the detrimental effects of social media use.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"71 ","pages":"Article 101479"},"PeriodicalIF":4.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-16DOI: 10.1016/j.dcn.2024.101478
Angelica M. Morales , Scott A. Jones , Birgitta Carlson , Dakota Kliamovich , Joseph Dehoney , Brooke L. Simpson , Kalene A. Dominguez-Savage , Kristina O. Hernandez , Daniel A. Lopez , Fiona C. Baker , Duncan B. Clark , David B. Goldston , Beatriz Luna , Kate B. Nooner , Eva M. Muller-Oehring , Susan F. Tapert , Wesley K. Thompson , Bonnie J. Nagel
Dopaminergic projections from the ventral tegmental area (VTA) to limbic regions play a key role in the initiation and maintenance of substance use; however, the relationship between mesolimbic resting-state functional connectivity (RSFC) and alcohol use during development remains unclear. We examined the associations between alcohol use and VTA RSFC to subcortical structures in 796 participants (12–21 years old at baseline, 51 % female) across 9 waves of longitudinal data from the National Consortium on Alcohol and Neurodevelopment in Adolescence. Linear mixed effects models included interactions between age, sex, and alcohol use, and best fitting models were selected using log-likelihood ratio tests. Results demonstrated a positive association between alcohol use and VTA RSFC to the nucleus accumbens. Age was associated with VTA RSFC to the amygdala and hippocampus, and an age-by-alcohol use interaction on VTA-globus pallidus connectivity was driven by a positive association between alcohol and VTA-globus pallidus RSFC in adolescence, but not adulthood. On average, male participants exhibited greater VTA RSFC to the amygdala, nucleus accumbens, caudate, hippocampus, globus pallidus, and thalamus. Differences in VTA RSFC related to age, sex, and alcohol, may inform our understanding of neurobiological risk and resilience for alcohol use and other psychiatric disorders
从腹侧被盖区（VTA）到边缘区域的多巴胺能投射在药物使用的开始和维持过程中起着关键作用；然而，在发育过程中，中边缘静息态功能连接（RSFC）与酒精使用之间的关系仍不清楚。我们研究了国家青少年酒精和神经发育联合会（National Consortium on Alcohol and Neurodevelopment in Adolescence）9波纵向数据中796名参与者（基线年龄为12-21岁，51%为女性）的酒精使用和VTA RSFC与皮层下结构之间的关系。线性混合效应模型包括年龄、性别和饮酒情况之间的交互作用，并通过对数似然比检验选择最佳拟合模型。结果表明，饮酒与通向伏隔核的 VTA RSFC 呈正相关。年龄与通往杏仁核和海马的VTA RSFC相关，年龄与饮酒对VTA-球丛苍白球连通性的交互作用是由青春期饮酒与VTA-球丛苍白球RSFC之间的正相关而非成年期饮酒所驱动的。平均而言，男性参与者的杏仁核、伏隔核、尾状核、海马、球状苍白球和丘脑的VTA RSFC更大。与年龄、性别和酒精有关的VTA RSFC差异可能有助于我们了解酗酒和其他精神疾病的神经生物学风险和恢复能力。
{"title":"Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood","authors":"Angelica M. Morales , Scott A. Jones , Birgitta Carlson , Dakota Kliamovich , Joseph Dehoney , Brooke L. Simpson , Kalene A. Dominguez-Savage , Kristina O. Hernandez , Daniel A. Lopez , Fiona C. Baker , Duncan B. Clark , David B. Goldston , Beatriz Luna , Kate B. Nooner , Eva M. Muller-Oehring , Susan F. Tapert , Wesley K. Thompson , Bonnie J. Nagel","doi":"10.1016/j.dcn.2024.101478","DOIUrl":"10.1016/j.dcn.2024.101478","url":null,"abstract":"<div><div>Dopaminergic projections from the ventral tegmental area (VTA) to limbic regions play a key role in the initiation and maintenance of substance use; however, the relationship between mesolimbic resting-state functional connectivity (RSFC) and alcohol use during development remains unclear. We examined the associations between alcohol use and VTA RSFC to subcortical structures in 796 participants (12–21 years old at baseline, 51 % female) across 9 waves of longitudinal data from the National Consortium on Alcohol and Neurodevelopment in Adolescence. Linear mixed effects models included interactions between age, sex, and alcohol use, and best fitting models were selected using log-likelihood ratio tests. Results demonstrated a positive association between alcohol use and VTA RSFC to the nucleus accumbens. Age was associated with VTA RSFC to the amygdala and hippocampus, and an age-by-alcohol use interaction on VTA-globus pallidus connectivity was driven by a positive association between alcohol and VTA-globus pallidus RSFC in adolescence, but not adulthood. On average, male participants exhibited greater VTA RSFC to the amygdala, nucleus accumbens, caudate, hippocampus, globus pallidus, and thalamus. Differences in VTA RSFC related to age, sex, and alcohol, may inform our understanding of neurobiological risk and resilience for alcohol use and other psychiatric disorders</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101478"},"PeriodicalIF":4.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-14DOI: 10.1016/j.dcn.2024.101477
Florencia Anunziata , Cynthia Cisneros , Maria Isabella Natale Castillo , Alexandra Perez , Valeria Rodriguez , Sheila De La Cruz , Karla Estrada , Abigaile Durbal , Mishaska Jaramillo , Lidia Enriquez Marquez , Janet Nuñez , Myriam Peralta-Carcelen , Jessica Lee Wisnowski , on behalf of the HBCD Spanish Language and Culture Committee
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. Central to its mission of reducing health disparities is the establishment of the Spanish Language and Culture Committee (SLCC) within the HBCD framework, a significant step towards demographic representation and inclusivity in research. By addressing linguistic and sociocultural barriers and embracing the diverse identities of Hispanic/Latine individuals nationwide, the SLCC aims to promote inclusion, equity, and representation of all Hispanic/Latine subgroups, a population that has been historically misrepresented in health research. In this paper we describe the role of the SLCC in advocating for Hispanic/Latine families within the study, ensuring their inclusion from inception. This report also provides an overview of the SLCC organization, workflow, challenges and lessons learned thus far to reduce stigma and improve study outcomes, highlighting recruitment and retention strategies for the Hispanic/Latine population, and expanding outreach to promote inclusion across diverse Hispanic/Latine subgroups in the United States.
HEALthy Brain and Child Development (HBCD) 研究是一项多站点前瞻性纵向队列研究，将从产前开始并计划到幼儿期对人脑、认知、行为、社会和情感发育进行研究。在 HBCD 框架内成立西班牙语和文化委员会（SLCC）是该研究减少健康差异的核心任务，这是在研究的人口代表性和包容性方面迈出的重要一步。通过解决语言和社会文化障碍以及接纳全国西班牙裔/拉丁裔个人的不同身份，西班牙语言和文化委员会旨在促进所有西班牙裔/拉丁裔亚群体的包容性、公平性和代表性，而这一群体在健康研究中历来代表性不足。在本文中，我们介绍了 SLCC 在研究中为西班牙裔/拉丁裔家庭进行宣传，确保从一开始就将他们纳入研究中的作用。本报告还概述了 SLCC 的组织结构、工作流程、挑战以及迄今为止为减少耻辱感和改善研究结果所吸取的经验教训，重点介绍了针对西班牙裔/拉丁裔人口的招募和保留策略，并扩大了外联范围，以促进美国不同的西班牙裔/拉丁裔亚群体的融入。
{"title":"¿Donde están? Hispanic/Latine inclusion, diversity and representation in the HEALthy Brain and Child Development Study (HBCD)","authors":"Florencia Anunziata , Cynthia Cisneros , Maria Isabella Natale Castillo , Alexandra Perez , Valeria Rodriguez , Sheila De La Cruz , Karla Estrada , Abigaile Durbal , Mishaska Jaramillo , Lidia Enriquez Marquez , Janet Nuñez , Myriam Peralta-Carcelen , Jessica Lee Wisnowski , on behalf of the HBCD Spanish Language and Culture Committee","doi":"10.1016/j.dcn.2024.101477","DOIUrl":"10.1016/j.dcn.2024.101477","url":null,"abstract":"<div><div>The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. Central to its mission of reducing health disparities is the establishment of the Spanish Language and Culture Committee (SLCC) within the HBCD framework, a significant step towards demographic representation and inclusivity in research. By addressing linguistic and sociocultural barriers and embracing the diverse identities of Hispanic/Latine individuals nationwide, the SLCC aims to promote inclusion, equity, and representation of all Hispanic/Latine subgroups, a population that has been historically misrepresented in health research. In this paper we describe the role of the SLCC in advocating for Hispanic/Latine families within the study, ensuring their inclusion from inception. This report also provides an overview of the SLCC organization, workflow, challenges and lessons learned thus far to reduce stigma and improve study outcomes, highlighting recruitment and retention strategies for the Hispanic/Latine population, and expanding outreach to promote inclusion across diverse Hispanic/Latine subgroups in the United States.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101477"},"PeriodicalIF":4.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.dcn.2024.101476
Valerie Karl , Dani Beck , Espen Eilertsen , Carmen Morawetz , Thea Wiker , Eira R. Aksnes , Linn.B. Norbom , Lia Ferschmann , Niamh MacSweeney , Irene Voldsbekk , Ole A. Andreassen , Lars T. Westlye , Dylan G. Gee , Haakon Engen , Christian K. Tamnes
Parental mental health is associated with children’s emotion regulation (ER) and risk for psychopathology. The relationship between parental psychopathology and children’s functional ER networks and whether connectivity patterns mediate the relationship between parent and youth psychopathology remains unexplored. Using resting-state functional magnetic resonance imaging data from the Adolescent Brain Cognitive Development Study (N = 4202, mean age = 10.0) and a multilevel approach, we analyzed the relationship between self-reported parental psychopathology and their offsprings’ connectivity of four ER networks, as well as associations with self-reported youth psychopathology at a 3-year follow-up. Parental internalizing and total problems were associated with 1) higher connectivity between a subcortical-cortical integrative and ventrolateral prefrontal cortical (PFC) network, 2) lower connectivity between dorsolateral and ventrolateral PFC networks involved in cognitive aspects of ER, and 3) lower connectivity within a subcortical ER network (β = −0.05–0.04). Parental externalizing and total problems were associated with lower connectivity within the integrative network (βext = −0.05; βtot = −0.04). Mediation analyses yielded direct effects of parental to youth psychopathology, but no mediation effect of ER network connectivity. Overall, our results show that ER network connectivity in youth is related to parental psychopathology, yet do not explain intergenerational transmission of psychopathology.
{"title":"Associations between parental psychopathology and youth functional emotion regulation brain networks","authors":"Valerie Karl , Dani Beck , Espen Eilertsen , Carmen Morawetz , Thea Wiker , Eira R. Aksnes , Linn.B. Norbom , Lia Ferschmann , Niamh MacSweeney , Irene Voldsbekk , Ole A. Andreassen , Lars T. Westlye , Dylan G. Gee , Haakon Engen , Christian K. Tamnes","doi":"10.1016/j.dcn.2024.101476","DOIUrl":"10.1016/j.dcn.2024.101476","url":null,"abstract":"<div><div>Parental mental health is associated with children’s emotion regulation (ER) and risk for psychopathology. The relationship between parental psychopathology and children’s functional ER networks and whether connectivity patterns mediate the relationship between parent and youth psychopathology remains unexplored. Using resting-state functional magnetic resonance imaging data from the Adolescent Brain Cognitive Development Study (N = 4202, mean age = 10.0) and a multilevel approach, we analyzed the relationship between self-reported parental psychopathology and their offsprings’ connectivity of four ER networks, as well as associations with self-reported youth psychopathology at a 3-year follow-up. Parental internalizing and total problems were associated with 1) higher connectivity between a subcortical-cortical integrative and ventrolateral prefrontal cortical (PFC) network, 2) lower connectivity between dorsolateral and ventrolateral PFC networks involved in cognitive aspects of ER, and 3) lower connectivity within a subcortical ER network (<em>β</em> = −0.05–0.04). Parental externalizing and total problems were associated with lower connectivity within the integrative network (<em>β</em><sub><em>ext</em></sub> = −0.05; <em>β</em><sub><em>tot</em></sub> = −0.04). Mediation analyses yielded direct effects of parental to youth psychopathology, but no mediation effect of ER network connectivity. Overall, our results show that ER network connectivity in youth is related to parental psychopathology, yet do not explain intergenerational transmission of psychopathology.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101476"},"PeriodicalIF":4.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Combining existing datasets to investigate key questions in developmental cognitive neuroscience brings exciting opportunities and unique challenges. However, many data pooling methods require identical or harmonized methodologies that are often not feasible. We propose Integrative Data Analysis (IDA) as a promising framework to advance developmental cognitive neuroscience with secondary data analysis. IDA serves to test hypotheses by combining data of the same construct from commensurate (but not identical) measures. To overcome idiosyncrasies of neuroimaging data, IDA explicitly evaluates if measures across studies assess the same construct. Moreover, IDA allows investigators to examine meaningful individual variability by de-confounding source-specific differences. To demonstrate IDA’s potential, we explain foundational concepts, outline necessary steps, and apply IDA to volumetric measures of hippocampal subfields from 443 4- to 17-year-olds across three independent studies. We identified commensurate measures of Cornu Ammonis (CA) 1, dentate gyrus (DG)/CA3, and Subiculum (Sub). Model testing supported use of IDA to create IDA factor scores. We found age-related differences in DG/CA3, not but CA1 and Sub volume in the integrated dataset. By successfully demonstrating IDA, our hope is that future innovations come from the combination of existing neuroimaging data to create representative integrated samples when testing critical developmental questions.
结合现有数据集来研究发育认知神经科学中的关键问题，既带来了令人兴奋的机遇，也带来了独特的挑战。然而，许多数据汇集方法需要相同或统一的方法，而这往往是不可行的。我们提出了整合数据分析（IDA）这一前景广阔的框架，通过二次数据分析来推动发育认知神经科学的发展。整合数据分析（IDA）的作用是通过合并来自相称（但不完全相同）测量方法的相同构造的数据来检验假设。为了克服神经影像数据的特殊性，IDA 明确评估了不同研究的测量数据是否评估了相同的构象。此外，IDA 还允许研究人员通过消除来源特异性差异来检查有意义的个体变异性。为了证明 IDA 的潜力，我们解释了基本概念，概述了必要步骤，并将 IDA 应用于三项独立研究中 443 名 4 至 17 岁儿童的海马亚区容积测量。我们确定了 Cornu Ammonis (CA) 1、齿状回 (DG)/CA3 和 Subiculum (Sub) 的相应测量值。模型测试支持使用 IDA 创建 IDA 因子分数。我们在综合数据集中发现了与年龄有关的 DG/CA3 差异，而不是 CA1 和 Sub 体积的差异。通过成功展示 IDA，我们希望未来的创新能够来自于现有神经影像数据的结合，从而在测试关键发育问题时创建具有代表性的综合样本。
{"title":"A data integration method for new advances in development cognitive neuroscience","authors":"Kelsey L. Canada , Tracy Riggins , Simona Ghetti , Noa Ofen , Ana.M. Daugherty","doi":"10.1016/j.dcn.2024.101475","DOIUrl":"10.1016/j.dcn.2024.101475","url":null,"abstract":"<div><div>Combining existing datasets to investigate key questions in developmental cognitive neuroscience brings exciting opportunities and unique challenges. However, many data pooling methods require identical or harmonized methodologies that are often not feasible. We propose Integrative Data Analysis (IDA) as a promising framework to advance developmental cognitive neuroscience with secondary data analysis. IDA serves to test hypotheses by combining data of the same construct from commensurate (but not identical) measures. To overcome idiosyncrasies of neuroimaging data, IDA explicitly evaluates if measures across studies assess the same construct. Moreover, IDA allows investigators to examine meaningful individual variability by de-confounding source-specific differences. To demonstrate IDA’s potential, we explain foundational concepts, outline necessary steps, and apply IDA to volumetric measures of hippocampal subfields from 443 4- to 17-year-olds across three independent studies. We identified commensurate measures of Cornu Ammonis (CA) 1, dentate gyrus (DG)/CA3, and Subiculum (Sub). Model testing supported use of IDA to create IDA factor scores. We found age-related differences in DG/CA3, not but CA1 and Sub volume in the integrated dataset. By successfully demonstrating IDA, our hope is that future innovations come from the combination of existing neuroimaging data to create representative integrated samples when testing critical developmental questions.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101475"},"PeriodicalIF":4.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-05DOI: 10.1016/j.dcn.2024.101473
Mark Curtis , John C. Flournoy , Sridhar Kandala , Ashley F.P. Sanders , Michael P. Harms , Adam Omary , Leah H. Somerville , Deanna M. Barch
Puberty and associated changes in pubertal hormones influence structural brain development. Hormones such as dehydroepiandrosterone (DHEA) and progesterone remain understudied, and it remains unclear how these aspects of puberty contribute uniquely to structural brain development. We used the Human Connectome Project in Development cross-sectional sample of 1304 youth (aged 5–21 years) to investigate unique contributions of sex, age, pubertal stage, DHEA, testosterone, estradiol, and progesterone to cortical thickness, surface area, and subcortical volume development within functionally-relevant networks. Sex and age explain the most unique variance in all three aspects of structural development. Pubertal stage and pubertal hormones uniquely contribute more to cortical surface area, compared to thickness. Among the pubertal hormones, progesterone contributed unique variance to surface area in the default mode network, as well as to thickness in the orbito-affective network. Pubertal mechanisms also contributed unique variance to subcortical volumes. This demonstrates unique relations of understudied pubertal hormones to brain structure development and may help understand risk for psychopathology.
青春期和青春期激素的相关变化会影响大脑结构的发育。对脱氢表雄酮（DHEA）和孕酮等激素的研究仍然不足，目前仍不清楚这些青春期激素对大脑结构发育的独特作用。我们利用人类发育连接组项目（Human Connectome Project in Development）对 1304 名青少年（5-21 岁）的横断面样本进行了研究，调查了性别、年龄、青春期阶段、DHEA、睾酮、雌二醇和孕酮对功能相关网络中皮层厚度、表面积和皮层下体积发育的独特贡献。在结构发育的所有三个方面，性别和年龄解释了最独特的差异。与厚度相比，青春期阶段和青春期激素对皮质表面积的独特贡献更大。在青春期荷尔蒙中，孕酮对默认模式网络的表面积和轨道-情感网络的厚度有独特的影响。青春期机制对皮层下体积也有独特的影响。这显示了未被充分研究的青春期激素与大脑结构发育的独特关系，可能有助于了解精神病理学的风险。
{"title":"Disentangling the unique contributions of age, pubertal stage, and pubertal hormones to brain structure in childhood and adolescence","authors":"Mark Curtis , John C. Flournoy , Sridhar Kandala , Ashley F.P. Sanders , Michael P. Harms , Adam Omary , Leah H. Somerville , Deanna M. Barch","doi":"10.1016/j.dcn.2024.101473","DOIUrl":"10.1016/j.dcn.2024.101473","url":null,"abstract":"<div><div>Puberty and associated changes in pubertal hormones influence structural brain development. Hormones such as dehydroepiandrosterone (DHEA) and progesterone remain understudied, and it remains unclear how these aspects of puberty contribute uniquely to structural brain development. We used the Human Connectome Project in Development cross-sectional sample of 1304 youth (aged 5–21 years) to investigate unique contributions of sex, age, pubertal stage, DHEA, testosterone, estradiol, and progesterone to cortical thickness, surface area, and subcortical volume development within functionally-relevant networks. Sex and age explain the most unique variance in all three aspects of structural development. Pubertal stage and pubertal hormones uniquely contribute more to cortical surface area, compared to thickness. Among the pubertal hormones, progesterone contributed unique variance to surface area in the default mode network, as well as to thickness in the orbito-affective network. Pubertal mechanisms also contributed unique variance to subcortical volumes. This demonstrates unique relations of understudied pubertal hormones to brain structure development and may help understand risk for psychopathology.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"70 ","pages":"Article 101473"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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