Developmental Cognitive Neuroscience最新文献_第3页

Phrase-level emotional salience modulates neural substrates of situation model building in developing readers. 短语水平的情绪显著性调节发展中读者情境模型构建的神经基质。

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-03-13 DOI: 10.1016/j.dcn.2026.101707

Andrea N Burgess, Sarah S Hughes-Berheim, Laurie E Cutting

Existing neurocognitive reading models highlight a left-lateralized brain network supporting word- to discourse-level processing, but they largely overlook emotion. Although emotion-related brain regions are active during discourse processing, the role of arousal (i.e., emotional intensity) remains underexplored. Prior neuroimaging work has shown that isolated words or whole passages varying in arousal evoke activity in brain regions associated with emotion and situation model processing. However, how arousal at the phrase level within passages may modulate neural activity is unclear, nor have studies investigated how individual differences in arousal responsiveness may be linked to reading comprehension ability, particularly in developing readers. Here, we used functional magnetic resonance imaging (fMRI) to examine the neural correlates of lexical arousal in 86 third-graders as they read passages. A parametric modulation analysis, using phrase-level arousal ratings from a validated lexical database, was used to investigate how fluctuations in arousal during passage reading correlated with neural activity. We demonstrated that phrase-level arousal was associated with increased activity in regions implicated in emotional processing and situation model construction: the right amygdala, striatum, and posterior insula, and the left dorsomedial prefrontal cortex (dmPFC). Additionally, dmPFC activity was associated with better reading comprehension ability, aligning with prior literature linking dmPFC to situation model building. This work highlights the importance of integrating lexical emotional dimensions into cognitive models of reading and supports the idea of using emotionally engaging materials to enhance comprehension for developing readers of all abilities.

现有的神经认知阅读模型强调了支持单词到话语处理的左侧脑网络，但它们在很大程度上忽略了情感。尽管与情绪相关的大脑区域在话语处理过程中是活跃的，但唤醒（即情绪强度）的作用仍未得到充分探讨。先前的神经成像工作表明，在与情绪和情境模型处理相关的大脑区域中，孤立的单词或整个段落的唤醒唤醒活动有所不同。然而，段落中短语水平的觉醒如何调节神经活动尚不清楚，也没有研究调查觉醒反应的个体差异如何与阅读理解能力联系起来，特别是在发展中的读者中。在这里，我们使用功能性磁共振成像（fMRI）检查了86名三年级学生在阅读文章时词汇唤起的神经关联。采用参数化调制分析，利用一个经过验证的词汇数据库中的短语级唤醒评级，研究了阅读过程中唤醒波动与神经活动之间的关系。我们证明，短语水平的觉醒与情绪处理和情境模型构建相关区域的活动增加有关：右侧杏仁核、纹状体、后岛和左侧背内侧前额叶皮层（dmPFC）。此外，dmPFC活动与更好的阅读理解能力有关，这与先前将dmPFC与情景模型构建联系起来的文献一致。这项工作强调了将词汇情感维度整合到阅读认知模型中的重要性，并支持使用具有情感吸引力的材料来提高读者对各种能力发展的理解。

{"title":"Phrase-level emotional salience modulates neural substrates of situation model building in developing readers.","authors":"Andrea N Burgess, Sarah S Hughes-Berheim, Laurie E Cutting","doi":"10.1016/j.dcn.2026.101707","DOIUrl":"https://doi.org/10.1016/j.dcn.2026.101707","url":null,"abstract":"<p><p>Existing neurocognitive reading models highlight a left-lateralized brain network supporting word- to discourse-level processing, but they largely overlook emotion. Although emotion-related brain regions are active during discourse processing, the role of arousal (i.e., emotional intensity) remains underexplored. Prior neuroimaging work has shown that isolated words or whole passages varying in arousal evoke activity in brain regions associated with emotion and situation model processing. However, how arousal at the phrase level within passages may modulate neural activity is unclear, nor have studies investigated how individual differences in arousal responsiveness may be linked to reading comprehension ability, particularly in developing readers. Here, we used functional magnetic resonance imaging (fMRI) to examine the neural correlates of lexical arousal in 86 third-graders as they read passages. A parametric modulation analysis, using phrase-level arousal ratings from a validated lexical database, was used to investigate how fluctuations in arousal during passage reading correlated with neural activity. We demonstrated that phrase-level arousal was associated with increased activity in regions implicated in emotional processing and situation model construction: the right amygdala, striatum, and posterior insula, and the left dorsomedial prefrontal cortex (dmPFC). Additionally, dmPFC activity was associated with better reading comprehension ability, aligning with prior literature linking dmPFC to situation model building. This work highlights the importance of integrating lexical emotional dimensions into cognitive models of reading and supports the idea of using emotionally engaging materials to enhance comprehension for developing readers of all abilities.</p>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"79 ","pages":"101707"},"PeriodicalIF":4.9,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Language exposure predicts infants’ neural processing of others’ actions based on language group 语言暴露基于语言群预测幼儿对他人行为的神经处理

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.dcn.2025.101645

Yiyi Wang , Marc Colomer , Hyesung Grace Hwang , Enda Tan , Nathan A. Fox , Amanda Woodward

What language a person speaks has been shown to divide even infants' worlds. However, open questions remain about what neural processes are involved in the differentiation of native and foreign speakers in the infant's brain. This study used electroencephalography (EEG) to examine the neural responses related to top-down attention (frontal theta synchronization), action processing (mu desynchronization), and approach-avoidance (frontal alpha asymmetry) of 8- to 12-month-old infants as they observed a native (English) speaker and a foreign (French) speaker perform a goal-directed action (i.e., grasping objects). We further examined whether infants’ language exposure modulated these neural responses. We found that monolingual infants exhibited stronger mu desynchronization when observing a native (versus foreign) speaker perform goal-directed actions. In contrast, non-monolingual (i.e., hearing more than one language) infants did not show a difference in mu desynchronization between native and foreign speakers. No language group and exposure effects were found for frontal theta and frontal alpha symmetry. These results suggest that infants’ emerging differentiation of native and foreign speakers is also manifested in their neural processing of goal-directed actions and that this neural action processing is shaped by early exposure to different languages.

一个人说什么语言甚至可以区分婴儿的世界。然而，婴儿大脑中哪些神经过程参与了本族语者和外族语者的区分，仍然是一个悬而未决的问题。本研究利用脑电图（EEG）研究了8- 12个月大的婴儿在观察母语（英语）和外语（法语）的人进行目标导向的动作（即抓取物体）时，与自上而下的注意（额叶θ同步）、动作处理（mu非同步）和接近回避（额叶α不对称）相关的神经反应。我们进一步研究了婴儿的语言暴露是否会调节这些神经反应。我们发现单语婴儿在观察母语（相对于外语）说话者的目标导向行为时表现出更强的mu去同步。相比之下，非单语（即听不止一种语言）婴儿在母语和外国人之间没有表现出mu不同步的差异。没有发现语言组和暴露对额叶θ和α对称的影响。这些结果表明，婴儿对母语和外语使用者的分化也表现在他们对目标导向行为的神经处理上，这种神经行为处理是由早期接触不同语言形成的。

{"title":"Language exposure predicts infants’ neural processing of others’ actions based on language group","authors":"Yiyi Wang , Marc Colomer , Hyesung Grace Hwang , Enda Tan , Nathan A. Fox , Amanda Woodward","doi":"10.1016/j.dcn.2025.101645","DOIUrl":"10.1016/j.dcn.2025.101645","url":null,"abstract":"<div><div>What language a person speaks has been shown to divide even infants' worlds. However, open questions remain about what neural processes are involved in the differentiation of native and foreign speakers in the infant's brain. This study used electroencephalography (EEG) to examine the neural responses related to top-down attention (frontal theta synchronization), action processing (mu desynchronization), and approach-avoidance (frontal alpha asymmetry) of 8- to 12-month-old infants as they observed a native (English) speaker and a foreign (French) speaker perform a goal-directed action (i.e., grasping objects). We further examined whether infants’ language exposure modulated these neural responses. We found that monolingual infants exhibited stronger mu desynchronization when observing a native (versus foreign) speaker perform goal-directed actions. In contrast, non-monolingual (i.e., hearing more than one language) infants did not show a difference in mu desynchronization between native and foreign speakers. No language group and exposure effects were found for frontal theta and frontal alpha symmetry. These results suggest that infants’ emerging differentiation of native and foreign speakers is also manifested in their neural processing of goal-directed actions and that this neural action processing is shaped by early exposure to different languages.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101645"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional associations between self-referential processing and depressive symptoms in early adolescents: A two-wave EEG study 青少年早期自我参照加工与抑郁症状的双向关联：一项双波脑电图研究。

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/j.dcn.2025.101658

Pan Liu, Jaron X.Y. Tan

The transition into adolescence is a critical period that features rapid development of the self and elevated depressive symptoms. Maladaptive self-referential processing is an identified cognitive risk factor that predicts the development of depression; elevated depressive symptoms may also reinforce maladaptive patterns of self-referential processing. However, longitudinal data that speak to the directional associations between these two constructs are limited: extant research has focused on simple behavioral measures of self-referential processing, and no work has examined the directional relationships between the neural substrates of self-referential processing and depressive symptoms. In this study, 115 community-dwelling youths (66 girls; Mean age/SD =11.00/1.16 years) completed an EEG version of the Self-Referent Encoding Task (SRET) and reported their depressive symptoms at baseline and approximately a year later. A larger anterior late positive potential (LPP) elicited by negative self-referential processing at T1 predicted higher depressive symptoms a year later, with baseline symptoms controlled for. Further, depressive symptoms at T1 predicted higher drift rate during negative self-referential processing at T2, with baseline drift rate controlled for. We provided novel evidence concerning the bidirectional relationships between self-referential processing and depressive symptoms in early adolescence, with differential patterns observed in different indices of self-referential processing (neural or behavioral).

进入青春期是自我快速发展和抑郁症状加剧的关键时期。适应不良的自我参照加工是预测抑郁症发展的认知危险因素；抑郁症状的升高也可能强化自我参照处理的不适应模式。然而，说明这两个构念之间的定向关联的纵向数据是有限的：现有的研究主要集中在自我参照加工的简单行为测量上，没有工作检查自我参照加工的神经基质与抑郁症状之间的定向关系。在这项研究中，115名社区青年（66名女孩，平均年龄/SD =11.00/1.16岁）完成了脑电图版本的自我参照编码任务（SRET），并在基线和大约一年后报告了他们的抑郁症状。在基线症状得到控制的情况下，T1时由负性自我参照加工诱发的较大的前晚期正电位（LPP）预测一年后较高的抑郁症状。此外，T1时的抑郁症状预测T2时负性自我参照加工的漂移率更高，基线漂移率控制为。我们为青少年早期自我参照加工与抑郁症状之间的双向关系提供了新的证据，在不同的自我参照加工指数（神经或行为）中观察到不同的模式。

{"title":"Bidirectional associations between self-referential processing and depressive symptoms in early adolescents: A two-wave EEG study","authors":"Pan Liu, Jaron X.Y. Tan","doi":"10.1016/j.dcn.2025.101658","DOIUrl":"10.1016/j.dcn.2025.101658","url":null,"abstract":"<div><div>The transition into adolescence is a critical period that features rapid development of the self and elevated depressive symptoms. Maladaptive self-referential processing is an identified cognitive risk factor that predicts the development of depression; elevated depressive symptoms may also reinforce maladaptive patterns of self-referential processing. However, longitudinal data that speak to the directional associations between these two constructs are limited: extant research has focused on simple behavioral measures of self-referential processing, and no work has examined the directional relationships between the neural substrates of self-referential processing and depressive symptoms. In this study, 115 community-dwelling youths (66 girls; Mean age/SD =11.00/1.16 years) completed an EEG version of the Self-Referent Encoding Task (SRET) and reported their depressive symptoms at baseline and approximately a year later. A larger anterior late positive potential (LPP) elicited by negative self-referential processing at T1 predicted higher depressive symptoms a year later, with baseline symptoms controlled for. Further, depressive symptoms at T1 predicted higher drift rate during negative self-referential processing at T2, with baseline drift rate controlled for. We provided novel evidence concerning the bidirectional relationships between self-referential processing and depressive symptoms in early adolescence, with differential patterns observed in different indices of self-referential processing (neural or behavioral).</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101658"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pubertal timing and tempo differentially influence cortical and subcortical maturation in adolescence 青春期发育的时间和节奏对青春期皮层和皮层下的成熟有不同的影响。

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-01-01 Epub Date: 2025-12-12 DOI: 10.1016/j.dcn.2025.101657

Clare F. McCann , Theresa W. Cheng , Kathryn L. Mills , Jennifer A. Silvers

Puberty is a developmental period marked by an influx of sex steroids, which trigger physical and psychological changes. Furthermore, puberty elicits changes in structural brain development that are distinct from those associated with chronological age. Emerging evidence suggests that interindividual differences in pubertal development, such as timing, whether one reaches puberty milestones before or after peers, and tempo, or whether one progresses through puberty at a slower or faster rate than peers, may also play a significant role in shaping structural brain development. The present study leverages longitudinal data from the Adolescent Brain Cognitive Development^SM (ABCD Study®) to disentangle the influences of pubertal timing and tempo from chronological age on cortical and subcortical structural brain development during the adolescent period. Individuals with earlier timing tend to exhibit accelerated normative developmental trajectories compared to later timing peers, while individuals with faster tempos tend to exhibit thicker cortices, more cortical surface area, and greater subcortical volume compared to slower tempo peers. These findings underscore the significance of incorporating pubertal timing and tempo into models of structural brain development during puberty, thereby enhancing our understanding of variations in neurodevelopmental trajectories during adolescence.

青春期是一个以性类固醇大量涌入为标志的发育时期，它会引发身体和心理上的变化。此外，青春期引发的大脑结构发育变化与实足年龄相关的变化不同。越来越多的证据表明，青春期发育的个体差异，比如时间，一个人是在同龄人之前还是之后到达青春期里程碑，以及节奏，或者一个人在青春期的进展速度比同龄人慢还是快，也可能在塑造大脑结构发育中发挥重要作用。本研究利用青少年大脑认知发展研究（ABCD study®）的纵向数据，探讨青春期时间和发育速度对青少年大脑皮层和皮层下结构发育的影响。与节奏较慢的同龄人相比，节奏较早的个体往往表现出更快的规范性发展轨迹，而节奏较快的个体则表现出更厚的皮层、更大的皮层表面积和更大的皮层下体积。这些发现强调了将青春期时间和节奏纳入青春期大脑结构发育模型的重要性，从而增强了我们对青春期神经发育轨迹变化的理解。

{"title":"Pubertal timing and tempo differentially influence cortical and subcortical maturation in adolescence","authors":"Clare F. McCann , Theresa W. Cheng , Kathryn L. Mills , Jennifer A. Silvers","doi":"10.1016/j.dcn.2025.101657","DOIUrl":"10.1016/j.dcn.2025.101657","url":null,"abstract":"<div><div>Puberty is a developmental period marked by an influx of sex steroids, which trigger physical and psychological changes. Furthermore, puberty elicits changes in structural brain development that are distinct from those associated with chronological age. Emerging evidence suggests that interindividual differences in pubertal development, such as timing, whether one reaches puberty milestones before or after peers, and tempo, or whether one progresses through puberty at a slower or faster rate than peers, may also play a significant role in shaping structural brain development. The present study leverages longitudinal data from the <strong>Adolescent Brain Cognitive Development</strong><sup><strong>SM</strong></sup> <strong>(ABCD Study®)</strong> to disentangle the influences of pubertal timing and tempo from chronological age on cortical and subcortical structural brain development during the adolescent period. Individuals with earlier timing tend to exhibit accelerated normative developmental trajectories compared to later timing peers, while individuals with faster tempos tend to exhibit thicker cortices, more cortical surface area, and greater subcortical volume compared to slower tempo peers. These findings underscore the significance of incorporating pubertal timing and tempo into models of structural brain development during puberty, thereby enhancing our understanding of variations in neurodevelopmental trajectories during adolescence.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101657"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contributions of neighborhood violent crime and perceived neighborhood safety to cognition and mental health in the adolescent brain cognitive development study 青少年大脑认知发展研究中邻里暴力犯罪和邻里安全感对认知和心理健康的影响

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-01-01 Epub Date: 2025-12-18 DOI: 10.1016/j.dcn.2025.101660

Patrick M. Lindsley , Nourhan M. Elsayed , Deanna M. Barch

Introduction

This study investigates how objective neighborhood violence and perceived neighborhood safety (PNS) relate to adolescent mental health, cognitive performance, and brain structure. We examined whether PNS moderated the effects of neighborhood violence, explored neural correlates of PNS, tested longitudinal relationships, and assessed sociodemographic and psychological predictors of PNS.

Methods

Data from the ABCD Study (n = 11,865) were used to examine associations between PNS, violent crime, and youth outcomes. Measures included youth and caregiver surveys, FBI crime data, NIH Toolbox cognitive tasks, and MRI-based brain volume metrics in stress-related regions.

Results

PNS, but not objective violence, was associated with fewer mental health symptoms and better cognitive performance. PNS was also related to sociodemographic variables and greater right amygdala volume. Longitudinally, baseline PNS predicted later cognitive performance, while baseline mental health and working memory predicted future PNS, indicating bidirectional effects.

Discussion

Perceived safety, rather than objective crime, was linked to adolescent mental health, cognition, and brain structure. PNS was influenced by sociodemographic and psychological factors, and mental health predicted declines in safety perception. These findings emphasize the developmental importance of subjective environmental experiences.

本研究探讨了客观邻里暴力和感知邻里安全（PNS）与青少年心理健康、认知表现和大脑结构的关系。我们研究了PNS是否能缓和邻里暴力的影响，探索了PNS的神经相关性，测试了PNS的纵向关系，并评估了PNS的社会人口学和心理预测因子。方法使用ABCD研究（n = 11865）的数据来检查PNS、暴力犯罪和青少年结局之间的关系。测量包括青少年和照顾者调查、FBI犯罪数据、NIH工具箱认知任务和基于核磁共振成像的压力相关区域脑容量指标。结果spns与较少的心理健康症状和更好的认知表现相关，但与客观暴力无关。PNS还与社会人口学变量和右侧杏仁核体积增大有关。纵向上，基线PNS预测后来的认知表现，而基线心理健康和工作记忆预测未来的PNS，表明双向效应。与青少年心理健康、认知和大脑结构相关的是感知安全，而非客观犯罪。PNS受社会人口学和心理因素的影响，心理健康预示着安全感知的下降。这些发现强调了主观环境体验对发展的重要性。

{"title":"Contributions of neighborhood violent crime and perceived neighborhood safety to cognition and mental health in the adolescent brain cognitive development study","authors":"Patrick M. Lindsley , Nourhan M. Elsayed , Deanna M. Barch","doi":"10.1016/j.dcn.2025.101660","DOIUrl":"10.1016/j.dcn.2025.101660","url":null,"abstract":"<div><h3>Introduction</h3><div>This study investigates how objective neighborhood violence and perceived neighborhood safety (PNS) relate to adolescent mental health, cognitive performance, and brain structure. We examined whether PNS moderated the effects of neighborhood violence, explored neural correlates of PNS, tested longitudinal relationships, and assessed sociodemographic and psychological predictors of PNS.</div></div><div><h3>Methods</h3><div>Data from the ABCD Study (n = 11,865) were used to examine associations between PNS, violent crime, and youth outcomes. Measures included youth and caregiver surveys, FBI crime data, NIH Toolbox cognitive tasks, and MRI-based brain volume metrics in stress-related regions.</div></div><div><h3>Results</h3><div>PNS, but not objective violence, was associated with fewer mental health symptoms and better cognitive performance. PNS was also related to sociodemographic variables and greater right amygdala volume. Longitudinally, baseline PNS predicted later cognitive performance, while baseline mental health and working memory predicted future PNS, indicating bidirectional effects.</div></div><div><h3>Discussion</h3><div>Perceived safety, rather than objective crime, was linked to adolescent mental health, cognition, and brain structure. PNS was influenced by sociodemographic and psychological factors, and mental health predicted declines in safety perception. These findings emphasize the developmental importance of subjective environmental experiences.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101660"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision functional neuroimaging reveals individually specific auditory responses in infants 精确的功能性神经成像揭示了婴儿个体特定的听觉反应

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-01-01 Epub Date: 2025-11-14 DOI: 10.1016/j.dcn.2025.101644

Julia Moser , Alyssa K. Labonte , Thomas J. Madison , Lana Hantzsch , Han H.N. Pham , Kimberly B. Weldon , M. Catalina Camacho , Rebecca F. Schwarzlose , Sanju Koirala , Jacob T. Lundquist , Sooyeon Sung , Cristian Morales Carrasco , Robert J.M. Hermosillo , Steven M. Nelson , Jed T. Elison , Damien A. Fair , Chad M. Sylvester

Adaptively responding to salient stimuli in the environment is a fundamental feature of cognitive development in early life, which is enabled by the developing brain. Understanding individual variability in how the brain supports this fundamental process is essential for uncovering neurodevelopmental trajectories and potential neurodevelopmental risks. In the present study, we used a precision functional imaging approach to probe activation in response to salient auditory stimuli and its relation to brain functional networks in individual infants. A minimum of 60 min of fMRI BOLD data with an auditory oddball paradigm were collected in ten infants with a mean postmenstrual age of 48 weeks. Results demonstrate the feasibility of conducting a precision functional imaging study to investigate individual specific responses to salient stimuli in infants. While responses to the auditory oddball were consistent across individuals in auditory processing areas, responses across the rest of the brain differed across individuals in their magnitude and time to peak. Individual specific response patterns appeared to be relatively stable and differed from other participant’s response patterns, despite fluctuations across runs. Commonalities and differences between individuals demonstrated in this sample contribute to our understanding of how the developing brain instantiates processing of salient stimuli. In this context, individual specific response patterns could be a promising target for biomarkers of normative brain and cognitive development.

对环境中的显著刺激作出适应性反应是早期认知发展的一个基本特征，这是由发育中的大脑实现的。了解大脑如何支持这一基本过程的个体差异对于揭示神经发育轨迹和潜在的神经发育风险至关重要。在本研究中，我们使用精确功能成像方法来探测个体婴儿对显著听觉刺激反应的激活及其与脑功能网络的关系。在10名平均经后年龄为48周的婴儿中，收集了至少60 min的fMRI BOLD数据，伴有听觉怪异范式。结果表明，进行精确功能成像研究，以调查婴儿对显著刺激的个体特异性反应的可行性。虽然每个人在听觉处理区域对古怪声音的反应是一致的，但大脑其他区域的反应在强度和达到峰值的时间上却存在差异。个体特定的反应模式似乎相对稳定，不同于其他参与者的反应模式，尽管在跑步过程中有所波动。在这个样本中展示的个体之间的共性和差异有助于我们理解发育中的大脑如何实例化显著刺激的处理。在这种情况下，个体特定的反应模式可能是规范大脑和认知发展的生物标志物的一个有希望的目标。

{"title":"Precision functional neuroimaging reveals individually specific auditory responses in infants","authors":"Julia Moser , Alyssa K. Labonte , Thomas J. Madison , Lana Hantzsch , Han H.N. Pham , Kimberly B. Weldon , M. Catalina Camacho , Rebecca F. Schwarzlose , Sanju Koirala , Jacob T. Lundquist , Sooyeon Sung , Cristian Morales Carrasco , Robert J.M. Hermosillo , Steven M. Nelson , Jed T. Elison , Damien A. Fair , Chad M. Sylvester","doi":"10.1016/j.dcn.2025.101644","DOIUrl":"10.1016/j.dcn.2025.101644","url":null,"abstract":"<div><div>Adaptively responding to salient stimuli in the environment is a fundamental feature of cognitive development in early life, which is enabled by the developing brain. Understanding individual variability in how the brain supports this fundamental process is essential for uncovering neurodevelopmental trajectories and potential neurodevelopmental risks. In the present study, we used a precision functional imaging approach to probe activation in response to salient auditory stimuli and its relation to brain functional networks in individual infants. A minimum of 60 min of fMRI BOLD data with an auditory oddball paradigm were collected in ten infants with a mean postmenstrual age of 48 weeks. Results demonstrate the feasibility of conducting a precision functional imaging study to investigate individual specific responses to salient stimuli in infants. While responses to the auditory oddball were consistent across individuals in auditory processing areas, responses across the rest of the brain differed across individuals in their magnitude and time to peak. Individual specific response patterns appeared to be relatively stable and differed from other participant’s response patterns, despite fluctuations across runs. Commonalities and differences between individuals demonstrated in this sample contribute to our understanding of how the developing brain instantiates processing of salient stimuli. In this context, individual specific response patterns could be a promising target for biomarkers of normative brain and cognitive development.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101644"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preterm birth, socioeconomic status, and white matter development across childhood 早产、社会经济地位和整个儿童时期的白质发育

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-01-01 Epub Date: 2025-11-08 DOI: 10.1016/j.dcn.2025.101643

Katie Mckinnon , Manuel Blesa Cábez , Melissa Thye , Selina Abel , Rebekah Smikle , Jean Skelton , Lorena Jiménez-Sánchez , Kadi Vaher , Gemma Sullivan , Amy Corrigan , Gayle Barclay , Charlotte Jardine , Iona Hamilton , Donna McIntyre , Yu Wei Chua , Ray Amir , Alan J. Quigley , Cheryl Battersby , Athanasios Tsanas , G. David Batty , James P. Boardman

Preterm birth and socioeconomic status (SES) are associated with brain development in early life, but the contribution of each over time is uncertain. We examined the effects of gestational age (GA) and SES on white matter microstructure in the neonatal period and at five years.

Participants included preterm and term children. Diffusion MRI was collected at term-equivalent age (n = 153 preterm, n = 90 term [127/243 female]) and from a subset at five years (n = 26 preterm, n = 32 term [22/58 female]). We assessed linear associations of GA, SES (Scottish Index of Multiple Deprivation [SIMD] and maternal education), and GA×SES interactions on fractional anisotropy (FA) using tract-based spatial statistics. We compared the proportion of voxels with significant associations between timepoints.

In preterm neonates, higher GA and higher maternal education, but not SIMD, were associated with higher FA (p corrected for family-wise error rate, p_FWER < 0.05). GA-FA associations depended on maternal education and SIMD (β =|0.001–0.005|, p < 0.001). At five years, the strength and direction of GA-FA associations depended on SIMD (β =|0.013–0.028|, p < 0.001), but not maternal education. In term infants, lower SES was associated with higher FA at the neonatal timepoint only (p_FWER < 0.05).

Preterm birth and SES both shape brain development at birth and continue to do so at five years. The SES measure most strongly associated with FA in preterm infants switches from a family-level (i.e. maternal education) to neighborhood-level (i.e. SIMD) measure between birth and five years, which suggests strategies to mitigate adverse effects of social inequalities on development may require adaptation as children grow.

早产和社会经济地位（SES）与生命早期的大脑发育有关，但随着时间的推移，两者的作用尚不确定。我们研究了胎龄（GA）和SES对新生儿期和5岁时白质微观结构的影响。参与者包括早产儿和足月儿童。在足月年龄（n = 153个早产儿，n = 90个早产儿[127/243名女性]）和5岁（n = 26个早产儿，n = 32个早产儿[22/58名女性]）收集弥散MRI。我们利用基于图的空间统计评估了GA、SES（苏格兰多重剥夺指数[SIMD]和母亲教育）和GA×SES在分数各向异性（FA）上的相互作用的线性关系。我们比较了时间点之间具有显著关联的体素比例。在早产儿中，较高的GA和较高的母亲教育程度与较高的FA相关，但与SIMD无关（p校正了家庭错误率，pFWER < 0.05）。GA-FA关联依赖于母亲教育程度和SIMD （β =|0.001 - 0.005|, p <； 0.001）。在5岁时，GA-FA关联的强度和方向取决于SIMD (β =| 0.013-0.028 |, p <； 0.001)，而不是母亲教育程度。在足月婴儿中，仅在新生儿时间点，较低的SES与较高的FA相关（pFWER < 0.05）。早产和SES都会在出生时影响大脑发育，并在5岁时继续影响大脑发育。与早产儿FA最密切相关的社会经济地位测量从出生到五岁之间从家庭层面（即母亲教育）转变为社区层面（即SIMD）测量，这表明减轻社会不平等对发展的不利影响的策略可能需要随着儿童的成长而适应。

{"title":"Preterm birth, socioeconomic status, and white matter development across childhood","authors":"Katie Mckinnon , Manuel Blesa Cábez , Melissa Thye , Selina Abel , Rebekah Smikle , Jean Skelton , Lorena Jiménez-Sánchez , Kadi Vaher , Gemma Sullivan , Amy Corrigan , Gayle Barclay , Charlotte Jardine , Iona Hamilton , Donna McIntyre , Yu Wei Chua , Ray Amir , Alan J. Quigley , Cheryl Battersby , Athanasios Tsanas , G. David Batty , James P. Boardman","doi":"10.1016/j.dcn.2025.101643","DOIUrl":"10.1016/j.dcn.2025.101643","url":null,"abstract":"<div><div>Preterm birth and socioeconomic status (SES) are associated with brain development in early life, but the contribution of each over time is uncertain. We examined the effects of gestational age (GA) and SES on white matter microstructure in the neonatal period and at five years.</div><div>Participants included preterm and term children. Diffusion MRI was collected at term-equivalent age (n = 153 preterm, n = 90 term [127/243 female]) and from a subset at five years (n = 26 preterm, n = 32 term [22/58 female]). We assessed linear associations of GA, SES (Scottish Index of Multiple Deprivation [SIMD] and maternal education), and GA×SES interactions on fractional anisotropy (FA) using tract-based spatial statistics. We compared the proportion of voxels with significant associations between timepoints.</div><div>In preterm neonates, higher GA and higher maternal education, but not SIMD, were associated with higher FA (<em>p</em> corrected for family-wise error rate, <em>p</em><sub><em>FWER</em></sub> < 0.05). GA-FA associations depended on maternal education and SIMD (β =|0.001–0.005|, <em>p</em> < 0.001). At five years, the strength and direction of GA-FA associations depended on SIMD (β =|0.013–0.028|, <em>p</em> < 0.001), but not maternal education. In term infants, lower SES was associated with higher FA at the neonatal timepoint only (<em>p</em><sub><em>FWER</em></sub> < 0.05).</div><div>Preterm birth and SES both shape brain development at birth and continue to do so at five years. The SES measure most strongly associated with FA in preterm infants switches from a family-level (i.e. maternal education) to neighborhood-level (i.e. SIMD) measure between birth and five years, which suggests strategies to mitigate adverse effects of social inequalities on development may require adaptation as children grow.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101643"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural basis of approach and avoidance responses to food in 12-month-old infants following emotional state changes 情绪状态变化后12月龄婴儿对食物接近和回避反应的神经基础。

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-01-01 Epub Date: 2025-12-07 DOI: 10.1016/j.dcn.2025.101656

Liam R. Chawner, Sayaka Kidby, Arkadij Lobov, Alejandra Sel, Maria L. Filippetti

Emotional Eating (EE) behaviours may emerge throughout childhood as a function of maladaptive interoceptive abilities, where eating occurs in response to emotional states rather than to satisfy hunger signals. Genetic and neurobiological factors contribute to EE, indicating that underlying neural mechanisms may precede the manifestation of these behaviours. We examined the neural processes associated with the early development of EE. Twelve-month-old infants attended the lab and ate lunch until satiation before being exposed to a frustration-inducing task. While wearing an EEG cap, infants viewed pictures of liked foods and non-foods. We measured infants’ behavioural reactivity to the frustration task, Frontal Alpha Asymmetry (FAA) indicating approach-avoidance responses to food and non-food stimuli, and collected parent-reported data on infant appetitive traits and temperament, and feeding practices. At low levels of emotional reactivity to frustration, infants showed more approach to non-food stimuli, whereas for some infants with higher emotional reactivity, stronger FAA approach activity was observed towards food stimuli. Additionally, parental use of feeding to regulate emotions predicted higher FAA approach responses to both food and non-food stimuli. These results suggest that infants’ neural responses to a change in emotional state are associated with approach-avoidance tendencies towards food and non-food stimuli, before EE behaviours emerge. However, associations between food approach tendencies and parental influences at 12months remain unclear.

情绪性进食（EE）行为可能在整个童年时期出现，作为一种适应不良的内感受能力的功能，在这种情况下，进食是对情绪状态的反应，而不是为了满足饥饿信号。遗传和神经生物学因素有助于情感表达，表明潜在的神经机制可能先于这些行为的表现。我们研究了与情感表达早期发展相关的神经过程。12个月大的婴儿在实验室里吃午饭，直到吃饱，然后再进行一项令人沮丧的任务。戴着脑电图帽的婴儿观看喜欢的食物和非食物的图片。我们测量了婴儿对挫折任务的行为反应，额叶α不对称（FAA）表明对食物和非食物刺激的接近-回避反应，并收集了父母报告的婴儿食欲特征和气质以及喂养方法的数据。在沮丧情绪反应水平较低的情况下，婴儿对非食物刺激表现出更多的接近，而在情绪反应水平较高的婴儿中，对食物刺激表现出更强的FAA接近活动。此外，父母使用喂养来调节情绪预测更高的FAA方法对食物和非食物刺激的反应。这些结果表明，在情感表达行为出现之前，婴儿对情绪状态变化的神经反应与对食物和非食物刺激的接近回避倾向有关。然而，12个月大的婴儿饮食倾向与父母影响之间的关系尚不清楚。

{"title":"Neural basis of approach and avoidance responses to food in 12-month-old infants following emotional state changes","authors":"Liam R. Chawner, Sayaka Kidby, Arkadij Lobov, Alejandra Sel, Maria L. Filippetti","doi":"10.1016/j.dcn.2025.101656","DOIUrl":"10.1016/j.dcn.2025.101656","url":null,"abstract":"<div><div>Emotional Eating (EE) behaviours may emerge throughout childhood as a function of maladaptive interoceptive abilities, where eating occurs in response to emotional states rather than to satisfy hunger signals. Genetic and neurobiological factors contribute to EE, indicating that underlying neural mechanisms may precede the manifestation of these behaviours. We examined the neural processes associated with the early development of EE. Twelve-month-old infants attended the lab and ate lunch until satiation before being exposed to a frustration-inducing task. While wearing an EEG cap, infants viewed pictures of liked foods and non-foods. We measured infants’ behavioural reactivity to the frustration task, Frontal Alpha Asymmetry (FAA) indicating approach-avoidance responses to food and non-food stimuli, and collected parent-reported data on infant appetitive traits and temperament, and feeding practices. At low levels of emotional reactivity to frustration, infants showed more approach to non-food stimuli, whereas for some infants with higher emotional reactivity, stronger FAA approach activity was observed towards food stimuli. Additionally, parental use of feeding to regulate emotions predicted higher FAA approach responses to both food and non-food stimuli. These results suggest that infants’ neural responses to a change in emotional state are associated with approach-avoidance tendencies towards food and non-food stimuli, before EE behaviours emerge. However, associations between food approach tendencies and parental influences at 12months remain unclear.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101656"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The origins of time: A systematic review of the neural signatures of temporal prediction in infancy 时间的起源：对婴儿期时间预测的神经特征的系统回顾。

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-01-01 Epub Date: 2025-12-04 DOI: 10.1016/j.dcn.2025.101655

Isabelle Rambosson , Damien Benis , Claire Kabdebon , Didier Grandjean , Manuela Filippa

Human social interaction relies on the ability to detect and predict the temporal organization of sensory events. Although these abilities change markedly across infancy, little is known about their underlying neural mechanisms. This systematic review aims to define the neural signatures of temporal prediction in newborns and infants and to identify gaps that should guide future longitudinal research. Eight peer-reviewed studies were included, with 228 infants from birth to 9 months of age. Across studies, neural signatures of temporal prediction have been reported in broad cortical areas, including the anterior and medial parts of the brain, particularly within the frontal and central regions. Current evidence suggests that infants' neural responses to temporal regularities likely reflect a combination of early sensory-driven responses and emerging top-down processes. Importantly, gaps in the literature highlight the need for systematic, longitudinal approaches to clarify how neural mechanisms of temporal prediction develop and how biological predispositions and early experiences, including rhythmic and musical interactions, may contribute to this trajectory.

人类的社会互动依赖于探测和预测感官事件的时间组织的能力。尽管这些能力在婴儿期发生了显著变化，但人们对其潜在的神经机制知之甚少。本系统综述旨在定义新生儿和婴儿时间预测的神经特征，并找出指导未来纵向研究的空白。八项同行评议的研究纳入了228名从出生到9个月大的婴儿。在研究中，时间预测的神经特征已经在广泛的皮质区域被报道，包括大脑的前部和内侧，特别是在额叶和中央区域。目前的证据表明，婴儿对时间规律的神经反应可能反映了早期感觉驱动反应和新兴自上而下过程的结合。重要的是，文献中的空白突出了需要系统的纵向方法来阐明时间预测的神经机制是如何发展的，以及生物倾向和早期经验（包括节奏和音乐的相互作用）是如何促成这一轨迹的。

{"title":"The origins of time: A systematic review of the neural signatures of temporal prediction in infancy","authors":"Isabelle Rambosson , Damien Benis , Claire Kabdebon , Didier Grandjean , Manuela Filippa","doi":"10.1016/j.dcn.2025.101655","DOIUrl":"10.1016/j.dcn.2025.101655","url":null,"abstract":"<div><div>Human social interaction relies on the ability to detect and predict the temporal organization of sensory events. Although these abilities change markedly across infancy, little is known about their underlying neural mechanisms. This systematic review aims to define the neural signatures of temporal prediction in newborns and infants and to identify gaps that should guide future longitudinal research. Eight peer-reviewed studies were included, with 228 infants from birth to 9 months of age. Across studies, neural signatures of temporal prediction have been reported in broad cortical areas, including the anterior and medial parts of the brain, particularly within the frontal and central regions. Current evidence suggests that infants' neural responses to temporal regularities likely reflect a combination of early sensory-driven responses and emerging top-down processes. Importantly, gaps in the literature highlight the need for systematic, longitudinal approaches to clarify how neural mechanisms of temporal prediction develop and how biological predispositions and early experiences, including rhythmic and musical interactions, may contribute to this trajectory.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101655"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural brain recovery following reductions in adolescent and young adult binge drinking: A longitudinal NCANDA study 青少年和年轻人酗酒减少后大脑结构恢复：一项纵向nanda研究

IF 4.9 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2026-01-01 Epub Date: 2025-12-05 DOI: 10.1016/j.dcn.2025.101653

Marybel R. Gonzalez , Ty Brumback , Madison K. Wickershiem , Edith V. Sullivan , Adolf Pfefferbaum , Duncan B. Clark , David B. Goldston , M.J. Meloy , Firas Naber , Eva M. Müller-Oehring , Angelica M. Morales , Fiona C. Baker , Kate B. Nooner , Bonnie J. Nagel , Kilian M. Pohl , Kenneth J. Sher , Sandra A. Brown , Susan F. Tapert , Wesley K. Thompson

Adolescence through young adulthood is a sensitive neurodevelopmental window characterized by ongoing maturation of gray and white matter and heightened vulnerability to alcohol’s neurotoxic effects. Although prior studies link binge drinking with disrupted brain development, the potential for recovery with reduced alcohol use remains underexplored. Using data from 690 participants (ages 12–29) in the National Consortium on Alcohol and NeuroDevelopment in Adolescence to Adulthood (NCANDA-A), we examined the longitudinal impact of binge drinking episodes, and reductions in binge drinking episodes, on regional gray and white matter volumes. Linear mixed-effects models assessed (1) past-year binge drinking frequency, (2) reductions below personal mean binge drinking across time, and (3) transitions in frequency of binge drinking across 10 annual neuroimaging assessments. Results showed that higher binge drinking frequency was associated with decreases in gray matter across frontal, parietal, temporal, and occipital cortices, as well as white matter reductions in frontolimbic and frontostriatal pathways. Reductions below personal mean drinking frequency were also associated with attenuated shrinkage in gray matter volumes. Participants who transitioned from frequent to infrequent binge drinking had significantly larger corpus callosum volumes compared to those with sustained frequent binge episodes. This longitudinal analysis demonstrates consistent negative effects of binge drinking on gray and white matter regions. Importantly, reductions in binge drinking provide evidence for neuroanatomical recovery, particularly in the corpus callosum, and suggest that the degree of recovery may vary by brain region and extent of alcohol use reduction during this key developmental period.

青春期到青年期是一个敏感的神经发育窗口期，其特征是灰质和白质的不断成熟，对酒精的神经毒性作用的脆弱性增加。尽管先前的研究将酗酒与大脑发育中断联系起来，但减少饮酒的康复潜力仍未得到充分探索。使用来自全国青少年至成年期酒精与神经发育协会（NCANDA-A） 690名参与者（12-29岁）的数据，我们检查了酗酒发作和酗酒发作减少对区域灰质和白质体积的纵向影响。线性混合效应模型评估了(1)过去一年的酗酒频率，(2)随着时间的推移，酗酒人数减少到个人平均水平以下，以及(3)在10年的神经影像学评估中酗酒频率的变化。结果表明，较高的酗酒频率与额叶、顶叶、颞叶和枕叶皮层的灰质减少以及额叶边缘和额纹状体通路的白质减少有关。低于个人平均饮酒频率也与灰质体积缩小有关。从频繁酗酒过渡到不频繁酗酒的参与者的胼胝体体积明显大于持续频繁酗酒的参与者。这项纵向分析表明，酗酒对灰质和白质区域的负面影响是一致的。重要的是，酗酒的减少为神经解剖恢复提供了证据，特别是在胼胝体中，并表明恢复的程度可能因大脑区域和在这一关键发育时期减少酒精使用的程度而异。

{"title":"Structural brain recovery following reductions in adolescent and young adult binge drinking: A longitudinal NCANDA study","authors":"Marybel R. Gonzalez , Ty Brumback , Madison K. Wickershiem , Edith V. Sullivan , Adolf Pfefferbaum , Duncan B. Clark , David B. Goldston , M.J. Meloy , Firas Naber , Eva M. Müller-Oehring , Angelica M. Morales , Fiona C. Baker , Kate B. Nooner , Bonnie J. Nagel , Kilian M. Pohl , Kenneth J. Sher , Sandra A. Brown , Susan F. Tapert , Wesley K. Thompson","doi":"10.1016/j.dcn.2025.101653","DOIUrl":"10.1016/j.dcn.2025.101653","url":null,"abstract":"<div><div>Adolescence through young adulthood is a sensitive neurodevelopmental window characterized by ongoing maturation of gray and white matter and heightened vulnerability to alcohol’s neurotoxic effects. Although prior studies link binge drinking with disrupted brain development, the potential for recovery with reduced alcohol use remains underexplored. Using data from 690 participants (ages 12–29) in the National Consortium on Alcohol and NeuroDevelopment in Adolescence to Adulthood (NCANDA-A), we examined the longitudinal impact of binge drinking episodes, and reductions in binge drinking episodes, on regional gray and white matter volumes. Linear mixed-effects models assessed (1) past-year binge drinking frequency, (2) reductions below personal mean binge drinking across time, and (3) transitions in frequency of binge drinking across 10 annual neuroimaging assessments. Results showed that higher binge drinking frequency was associated with decreases in gray matter across frontal, parietal, temporal, and occipital cortices, as well as white matter reductions in frontolimbic and frontostriatal pathways. Reductions below personal mean drinking frequency were also associated with attenuated shrinkage in gray matter volumes. Participants who transitioned from frequent to infrequent binge drinking had significantly larger corpus callosum volumes compared to those with sustained frequent binge episodes. This longitudinal analysis demonstrates consistent negative effects of binge drinking on gray and white matter regions. Importantly, reductions in binge drinking provide evidence for neuroanatomical recovery, particularly in the corpus callosum, and suggest that the degree of recovery may vary by brain region and extent of alcohol use reduction during this key developmental period.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101653"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0