Pub Date : 2025-10-03DOI: 10.1016/j.dcn.2025.101625
Natasha Duell , Gabriella M. Alvarez , Eva H. Telzer , Keely A. Muscatell
Racial and ethnic discrimination has lasting consequences for adolescent functioning, yet its impact on adolescent brain development is relatively understudied. Identifying the neural circuits affected by discrimination can reveal key insights into brain plasticity and resilience. This pre-registered, multi-method study examined the longitudinal effect of racial/ethnic discrimination on one indicator of executive function via resting state functional connectivity among 4669 adolescents of color (e.g., 44 % Latinx, 43 % Black, 13 % Asian, 8 % Native American) from the Adolescent Brain and Cognitive Development Study. Further, we explored familism and school support as social-environmental buffers. Greater discrimination impeded adolescents’ performance on the Flanker test of selective attention and inhibitory control via longitudinal effects on connectivity between the attention networks, specifically among youth evincing low familism. Among adolescents reporting low school support, greater discrimination was associated with heightened dorsal attention—salience network connectivity. Findings offer initial evidence for the neurobiological processes impacted by discrimination and social-environmental strengths that may “break the link” between discrimination and brain function.
{"title":"Racial/ethnic discrimination shapes adolescent brain connectivity: Social buffers and implications for executive function","authors":"Natasha Duell , Gabriella M. Alvarez , Eva H. Telzer , Keely A. Muscatell","doi":"10.1016/j.dcn.2025.101625","DOIUrl":"10.1016/j.dcn.2025.101625","url":null,"abstract":"<div><div>Racial and ethnic discrimination has lasting consequences for adolescent functioning, yet its impact on adolescent brain development is relatively understudied. Identifying the neural circuits affected by discrimination can reveal key insights into brain plasticity and resilience. This pre-registered, multi-method study examined the longitudinal effect of racial/ethnic discrimination on one indicator of executive function via resting state functional connectivity among 4669 adolescents of color (e.g., 44 % Latinx, 43 % Black, 13 % Asian, 8 % Native American) from the Adolescent Brain and Cognitive Development Study. Further, we explored familism and school support as social-environmental buffers. Greater discrimination impeded adolescents’ performance on the Flanker test of selective attention and inhibitory control via longitudinal effects on connectivity between the attention networks, specifically among youth evincing low familism. Among adolescents reporting low school support, greater discrimination was associated with heightened dorsal attention—salience network connectivity. Findings offer initial evidence for the neurobiological processes impacted by discrimination and social-environmental strengths that may “break the link” between discrimination and brain function.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101625"},"PeriodicalIF":4.9,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-02DOI: 10.1016/j.dcn.2025.101623
Emma Renwick , Kristabel Stark , Emily Tan , Jenna Gonzalez , Alexis Brieant
Increasing representation of youth in developmental neuroscience research is essential to elucidating neurobiological mechanisms of cognition, behavior, and mental health. However, the field faces critical challenges in optimizing recruitment strategies and reducing barriers to participation among underrepresented populations. To examine these challenges and identify solutions, we employed a qualitative approach to assess barriers to research participation among a sample of adolescents. Data were drawn from semi-structured online focus groups with adolescents in a rural area of the United States. The sample included 20 participants (ages 13–18 years, 65 % female). A subset of questions addressed interest in research participation and potential barriers, and data were analyzed using thematic analysis. Results indicated five key themes: transportation, time, safety, caregiver involvement, and other barriers. Many participants highlighted their reliance on caregivers for transportation, as well as concerns about the overall time commitment of research participation. Misconceptions about magnetic resonance imaging (MRI) contributed to adolescents' hesitancy to participate. Many of these barriers are relevant across research settings, but may be especially salient for youth in rural communities, a population often underrepresented in developmental neuroscience research. Based on the data, we offer potential solutions such as community outreach and education, fair compensation, and community-based partnerships.
{"title":"Understanding barriers to adolescent participation in developmental neuroscience research","authors":"Emma Renwick , Kristabel Stark , Emily Tan , Jenna Gonzalez , Alexis Brieant","doi":"10.1016/j.dcn.2025.101623","DOIUrl":"10.1016/j.dcn.2025.101623","url":null,"abstract":"<div><div>Increasing representation of youth in developmental neuroscience research is essential to elucidating neurobiological mechanisms of cognition, behavior, and mental health. However, the field faces critical challenges in optimizing recruitment strategies and reducing barriers to participation among underrepresented populations. To examine these challenges and identify solutions, we employed a qualitative approach to assess barriers to research participation among a sample of adolescents. Data were drawn from semi-structured online focus groups with adolescents in a rural area of the United States. The sample included 20 participants (ages 13–18 years, 65 % female). A subset of questions addressed interest in research participation and potential barriers, and data were analyzed using thematic analysis. Results indicated five key themes: transportation, time, safety, caregiver involvement, and other barriers. Many participants highlighted their reliance on caregivers for transportation, as well as concerns about the overall time commitment of research participation. Misconceptions about magnetic resonance imaging (MRI) contributed to adolescents' hesitancy to participate. Many of these barriers are relevant across research settings, but may be especially salient for youth in rural communities, a population often underrepresented in developmental neuroscience research. Based on the data, we offer potential solutions such as community outreach and education, fair compensation, and community-based partnerships.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101623"},"PeriodicalIF":4.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.dcn.2025.101622
Nina Raduner , Carmen Providoli , Sarah V. Di Pietro , Maya Schneebeli , Iliana I. Karipidis , Ella Casimiro , Saurabh Bedi , Michael von Rhein , Nora M. Raschle , Christian C. Ruff , Silvia Brem
Multisensory processing and learning shape cognitive and language development, influencing how we perceive and interact with the world from an early age. While multisensory processes mature into adolescence, it remains poorly understood how age influences multisensory associative learning. This study investigated age-related effects on multisensory processing and learning during audio-visual and tactile-visual learning in 67 children (5.7–13 years) by integrating behavioural and neuroimaging data with computational methods. A reinforcement-learning drift diffusion model revealed that older children processed information faster and made more efficient decisions on multisensory associations. These age-related increases coincided with higher activity in brain regions associated with cognitive control, multisensory integration, and memory retrieval, specifically during audio-visual learning. Notably, the bilateral anterior insula exhibited heightened activation in response to lower reward prediction errors, indicative of increased sensitivity to negative feedback with development. Finally, reward prediction errors modulated activation in reward processing and cognitive control regions, with this modulation remaining modality-independent and largely stable across age. In conclusion, while children employ similar learning strategies, older children make decisions more efficiently and engage neural resources more strongly. Our findings reflect ongoing maturation of neural networks supporting multisensory learning in middle childhood, enabling more adaptive learning in later childhood.
{"title":"Growing minds, integrating senses: Neural and computational insights into age-related changes in audio-visual and tactile-visual learning in children","authors":"Nina Raduner , Carmen Providoli , Sarah V. Di Pietro , Maya Schneebeli , Iliana I. Karipidis , Ella Casimiro , Saurabh Bedi , Michael von Rhein , Nora M. Raschle , Christian C. Ruff , Silvia Brem","doi":"10.1016/j.dcn.2025.101622","DOIUrl":"10.1016/j.dcn.2025.101622","url":null,"abstract":"<div><div>Multisensory processing and learning shape cognitive and language development, influencing how we perceive and interact with the world from an early age. While multisensory processes mature into adolescence, it remains poorly understood how age influences multisensory associative learning. This study investigated age-related effects on multisensory processing and learning during audio-visual and tactile-visual learning in 67 children (5.7–13 years) by integrating behavioural and neuroimaging data with computational methods. A reinforcement-learning drift diffusion model revealed that older children processed information faster and made more efficient decisions on multisensory associations. These age-related increases coincided with higher activity in brain regions associated with cognitive control, multisensory integration, and memory retrieval, specifically during audio-visual learning. Notably, the bilateral anterior insula exhibited heightened activation in response to lower reward prediction errors, indicative of increased sensitivity to negative feedback with development. Finally, reward prediction errors modulated activation in reward processing and cognitive control regions, with this modulation remaining modality-independent and largely stable across age. In conclusion, while children employ similar learning strategies, older children make decisions more efficiently and engage neural resources more strongly. Our findings reflect ongoing maturation of neural networks supporting multisensory learning in middle childhood, enabling more adaptive learning in later childhood.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101622"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.dcn.2025.101612
Madison Politte-Corn, Sarah Myruski, Bridget Cahill, Koraly Pérez-Edgar, Kristin A. Buss
{"title":"Corrigendum to “Disentangling the role of different resting-state neural markers of adolescent behavioral inhibition and social anxiety” [Dev. Cogn. Neurosci. 73 (2025) 101560]","authors":"Madison Politte-Corn, Sarah Myruski, Bridget Cahill, Koraly Pérez-Edgar, Kristin A. Buss","doi":"10.1016/j.dcn.2025.101612","DOIUrl":"10.1016/j.dcn.2025.101612","url":null,"abstract":"","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101612"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145055389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.dcn.2025.101615
Jessica A. Church, Juliet Y. Davidow, Deanna J. Greene, Tracy Riggins
{"title":"Introduction to the special issue from Flux Congress 2023","authors":"Jessica A. Church, Juliet Y. Davidow, Deanna J. Greene, Tracy Riggins","doi":"10.1016/j.dcn.2025.101615","DOIUrl":"10.1016/j.dcn.2025.101615","url":null,"abstract":"","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101615"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01Epub Date: 2025-07-25DOI: 10.1016/j.dcn.2025.101600
Lydia Lewis, Bria Gresham, Amy Riegelman, Ka I Ip
The neighborhood context is increasingly recognized as a significant determinant of health. Advances in geospatial analysis and neuroimaging have facilitated an emerging field of research investigating how neighborhood conditions influence brain development. We conducted a systematic review, identifying 37 studies that examined associations between neighborhood conditions and brain structure in children and adolescents. We highlight key findings and research gaps across multiple domains of neighborhood conditions - socioeconomic status, demographic composition, social environment, built environment, physical environment, and health resources. Our review suggests that adverse neighborhood socioeconomic conditions are linked to structural brain differences, including reduced brain volume and white matter, and smaller surface areas. Additionally, observed race-related disparities in brain structures may be partially explained by residence in low-resourced neighborhoods, underscoring the role of structural inequities in shaping neurodevelopment. The majority of studies relied on the Adolescent Brain Cognitive Development Study dataset, limiting the generalizability of findings. Critically, neighborhood conditions beyond socioeconomic status remain understudied, offering opportunities for future research to examine how positive conditions (e.g., social cohesion, greenspace, health resources) may foster neurodevelopment. This review emphasizes the urgent need for policies to reduce structural inequities while leveraging protective neighborhood conditions to promote equity and youth neurodevelopment.
{"title":"Neighborhood conditions and neurodevelopment: A systematic review of brain structure in children and adolescents.","authors":"Lydia Lewis, Bria Gresham, Amy Riegelman, Ka I Ip","doi":"10.1016/j.dcn.2025.101600","DOIUrl":"10.1016/j.dcn.2025.101600","url":null,"abstract":"<p><p>The neighborhood context is increasingly recognized as a significant determinant of health. Advances in geospatial analysis and neuroimaging have facilitated an emerging field of research investigating how neighborhood conditions influence brain development. We conducted a systematic review, identifying 37 studies that examined associations between neighborhood conditions and brain structure in children and adolescents. We highlight key findings and research gaps across multiple domains of neighborhood conditions - socioeconomic status, demographic composition, social environment, built environment, physical environment, and health resources. Our review suggests that adverse neighborhood socioeconomic conditions are linked to structural brain differences, including reduced brain volume and white matter, and smaller surface areas. Additionally, observed race-related disparities in brain structures may be partially explained by residence in low-resourced neighborhoods, underscoring the role of structural inequities in shaping neurodevelopment. The majority of studies relied on the Adolescent Brain Cognitive Development Study dataset, limiting the generalizability of findings. Critically, neighborhood conditions beyond socioeconomic status remain understudied, offering opportunities for future research to examine how positive conditions (e.g., social cohesion, greenspace, health resources) may foster neurodevelopment. This review emphasizes the urgent need for policies to reduce structural inequities while leveraging protective neighborhood conditions to promote equity and youth neurodevelopment.</p>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"101600"},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-26DOI: 10.1016/j.dcn.2025.101617
Benjamin M. Rosenberg , João F. Guassi Moreira , Adriana S. Méndez Leal , Natalie M. Saragosa-Harris , Elizabeth Gaines , Wesley J. Meredith , Clare F. McCann , Saché M. Coury , Yael Waizman , Emilia Ninova , Jennifer A. Silvers
Institutionalization is a profound form of early adversity that is associated with increased risk for internalizing disorders, which most commonly have their onset during adolescence. Developmental models emphasize how differences in childhood learning contribute to avoidance behaviors, a core pathway linking adversity to internalizing disorders. Yet, little empirical research has tested this theory. 43 previously institutionalized (PI; 12.1–22.8 years) and 47 comparison (9.9–22.9 years) youth completed an aversive learning task while undergoing fMRI. The task involved an escapable stimulus reinforced with an aversive sound (CS+r), the same stimulus without reinforcement (CS+nr), and an escapable stimulus that was never reinforced (CS-). Internalizing symptoms were measured using the parent-report Revised Child Anxiety and Depression Scales. Functional connectivity between the nucleus accumbens (NAcc) and amygdala was elevated among the PI versus comparison youth across stimuli (p = .036). Exploratory analyses found that NAcc-amygdala connectivity was elevated among the PI youth during early adolescence relative to late adolescence (p = .009). Institutionalization may impact neurodevelopment in ways that increase responsiveness of threat neurocircuitry across threatening and safe stimuli. Differences in NAcc-amygdala functional connectivity may attenuate with age following adoption.
{"title":"Previous institutionalization is associated with elevated functional connectivity between the nucleus accumbens and amygdala during aversive learning","authors":"Benjamin M. Rosenberg , João F. Guassi Moreira , Adriana S. Méndez Leal , Natalie M. Saragosa-Harris , Elizabeth Gaines , Wesley J. Meredith , Clare F. McCann , Saché M. Coury , Yael Waizman , Emilia Ninova , Jennifer A. Silvers","doi":"10.1016/j.dcn.2025.101617","DOIUrl":"10.1016/j.dcn.2025.101617","url":null,"abstract":"<div><div>Institutionalization is a profound form of early adversity that is associated with increased risk for internalizing disorders, which most commonly have their onset during adolescence. Developmental models emphasize how differences in childhood learning contribute to avoidance behaviors, a core pathway linking adversity to internalizing disorders. Yet, little empirical research has tested this theory. 43 previously institutionalized (PI; 12.1–22.8 years) and 47 comparison (9.9–22.9 years) youth completed an aversive learning task while undergoing fMRI. The task involved an escapable stimulus reinforced with an aversive sound (CS+<sub>r</sub>), the same stimulus without reinforcement (CS+<sub>nr</sub>), and an escapable stimulus that was never reinforced (CS-). Internalizing symptoms were measured using the parent-report Revised Child Anxiety and Depression Scales. Functional connectivity between the nucleus accumbens (NAcc) and amygdala was elevated among the PI versus comparison youth across stimuli (<em>p</em> = .036). Exploratory analyses found that NAcc-amygdala connectivity was elevated among the PI youth during early adolescence relative to late adolescence (<em>p</em> = .009). Institutionalization may impact neurodevelopment in ways that increase responsiveness of threat neurocircuitry across threatening and safe stimuli. Differences in NAcc-amygdala functional connectivity may attenuate with age following adoption.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101617"},"PeriodicalIF":4.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-25DOI: 10.1016/j.dcn.2025.101619
Anna Blasi Ribera , Borja Blanco Maniega , Samantha McCann , Ebrima Mbye , Ebou Touray , Maria Rozhko , Bosiljka Milosavljevic , Laura Katus , Mariama Saidykhan , Muhammed Ceesay , Tijan Fadera , Giulia Ghillia , Marta Perapoch Amado , Maria M. Crespo-Llado , Sophie E. Moore , Clare E. Elwell , Sarah Lloyd-Fox , The BRIGHT Project team
As infants and young children learn from and respond to their environment, their development is driven by their ability to filter out irrelevant stimuli and respond to salient stimuli. While sources and types of stimuli vary across cultural contexts, research to understand the neural mechanisms of these behaviors have largely focused on relatively homogeneous populations in high income settings. To address this lack of diverse representation the Brain Imaging for Global health project (BRIGHT) collected longitudinal data in The Gambia (N = 204) and the UK (N = 61). Here we present results of the Habituation and Novelty Detection (HaND) fNIRS neuroimaging task. Gambian infants showed persistent response suppression (Habituation) at all visits (from 5mo to 60mo) while Novelty Detection was only observed once infants reached 18 and 24mo. In the UK, infants only showed persistent habituation from 5 to 12mo, while the response was not evident at 18 and 24mo. Furthermore, in contrast to The Gambia, alongside the habituation patterns observed Uk infants showed novelty detection from 5 to 12mo. This is the first longitudinal description of the HaND response in individuals from different contextual backgrounds across such a broad age range and number of time points, revealing different patterns of specialization in The Gambia and UK.
{"title":"Longitudinal habituation and novelty detection neural responses from infancy to early childhood in The Gambia and UK","authors":"Anna Blasi Ribera , Borja Blanco Maniega , Samantha McCann , Ebrima Mbye , Ebou Touray , Maria Rozhko , Bosiljka Milosavljevic , Laura Katus , Mariama Saidykhan , Muhammed Ceesay , Tijan Fadera , Giulia Ghillia , Marta Perapoch Amado , Maria M. Crespo-Llado , Sophie E. Moore , Clare E. Elwell , Sarah Lloyd-Fox , The BRIGHT Project team","doi":"10.1016/j.dcn.2025.101619","DOIUrl":"10.1016/j.dcn.2025.101619","url":null,"abstract":"<div><div>As infants and young children learn from and respond to their environment, their development is driven by their ability to filter out irrelevant stimuli and respond to salient stimuli. While sources and types of stimuli vary across cultural contexts, research to understand the neural mechanisms of these behaviors have largely focused on relatively homogeneous populations in high income settings. To address this lack of diverse representation the Brain Imaging for Global health project (BRIGHT) collected longitudinal data in The Gambia (N = 204) and the UK (N = 61). Here we present results of the Habituation and Novelty Detection (HaND) fNIRS neuroimaging task. Gambian infants showed persistent response suppression (Habituation) at all visits (from 5mo to 60mo) while Novelty Detection was only observed once infants reached 18 and 24mo. In the UK, infants only showed persistent habituation from 5 to 12mo, while the response was not evident at 18 and 24mo. Furthermore, in contrast to The Gambia, alongside the habituation patterns observed Uk infants showed novelty detection from 5 to 12mo. This is the first longitudinal description of the HaND response in individuals from different contextual backgrounds across such a broad age range and number of time points, revealing different patterns of specialization in The Gambia and UK.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101619"},"PeriodicalIF":4.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-25DOI: 10.1016/j.dcn.2025.101620
Caitlyn R. Cody , Rebecca R. Hennessy , Heather C. Brenhouse, Juliet Y. Davidow
Adolescence is a dynamic time period, marked by significant neural and behavioral maturation. However, much remains unknown about how this maturation alters the way anxiety is expressed in this population, or how similar behavioral patterns may arise from divergent neural underpinnings. This translational review describes key differences between adolescent and adult manifestation of anxiety in rodents and humans. We suggest potential underlying developmental mechanisms in behavior and the brain across species that may contribute to age-related differences. We focus on cognitive factors that play a role in or are impaired by anxiety within three domains: fear, reward, and attentional processing. We review how and to what degree these processes and their interactions with anxiety manifest in youth compared to adults, and where known, with underlying neural circuits across species. Therefore, this review aims to provide insight into the translational neural and behavioral developmental nuances of anxiety in order to encourage further anxiety research utilizing adolescent humans and rodents.
{"title":"Understanding adolescent anxiety through a neurodevelopmental lens: A comparative review of rodents and humans","authors":"Caitlyn R. Cody , Rebecca R. Hennessy , Heather C. Brenhouse, Juliet Y. Davidow","doi":"10.1016/j.dcn.2025.101620","DOIUrl":"10.1016/j.dcn.2025.101620","url":null,"abstract":"<div><div>Adolescence is a dynamic time period, marked by significant neural and behavioral maturation. However, much remains unknown about how this maturation alters the way anxiety is expressed in this population, or how similar behavioral patterns may arise from divergent neural underpinnings. This translational review describes key differences between adolescent and adult manifestation of anxiety in rodents and humans. We suggest potential underlying developmental mechanisms in behavior and the brain across species that may contribute to age-related differences. We focus on cognitive factors that play a role in or are impaired by anxiety within three domains: fear, reward, and attentional processing. We review how and to what degree these processes and their interactions with anxiety manifest in youth compared to adults, and where known, with underlying neural circuits across species. Therefore, this review aims to provide insight into the translational neural and behavioral developmental nuances of anxiety in order to encourage further anxiety research utilizing adolescent humans and rodents.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101620"},"PeriodicalIF":4.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-25DOI: 10.1016/j.dcn.2025.101621
Natalie G. Frye , Tehila Nugiel , Gabriella M. Alvarez , Mitch J. Prinstein , Jessica R. Cohen , Eva H. Telzer , Kristen A. Lindquist
The present study examines the role of brain network organization in the prospective prediction of adolescent depressive symptoms and links to the social and psychological context. Using a path model with data from a larger longitudinal study of adolescents beginning in 6th-8th grade (N = 117, 55 % female, Mage at scan= 12.99), we first established that organizational properties of brain networks theoretically linked to depression predicted greater depressive symptoms two years later. Specifically, when controlling for gender and initial depression, greater global efficiency of the allostatic interoceptive network (AIN) and greater segregation of the frontoparietal network (FPN) from the salience network (SN) predicted depressive symptoms an average of two years later. Linking these neural findings to psychological individual differences, we found that self-reported rumination mediated the effect of AIN global efficiency on prospective depressive symptoms. We further linked these neural findings to the social context by demonstrating that greater self-reported relational peer victimization prospectively predicted AIN global efficiency. Collectively, these findings situate the emergence of adolescent depressive symptoms as a confluence of brain organization properties, perceived social rejection, and individual differences in rumination.
{"title":"Functional organization of the allostatic interoceptive network in adolescence: Links to peer victimization and prospective depressive symptoms","authors":"Natalie G. Frye , Tehila Nugiel , Gabriella M. Alvarez , Mitch J. Prinstein , Jessica R. Cohen , Eva H. Telzer , Kristen A. Lindquist","doi":"10.1016/j.dcn.2025.101621","DOIUrl":"10.1016/j.dcn.2025.101621","url":null,"abstract":"<div><div>The present study examines the role of brain network organization in the prospective prediction of adolescent depressive symptoms and links to the social and psychological context. Using a path model with data from a larger longitudinal study of adolescents beginning in 6th-8th grade (N = 117, 55 % female, M<sub>age at scan</sub>= 12.99), we first established that organizational properties of brain networks theoretically linked to depression predicted greater depressive symptoms two years later. Specifically, when controlling for gender and initial depression, greater global efficiency of the allostatic interoceptive network (AIN) and greater segregation of the frontoparietal network (FPN) from the salience network (SN) predicted depressive symptoms an average of two years later. Linking these neural findings to psychological individual differences, we found that self-reported rumination mediated the effect of AIN global efficiency on prospective depressive symptoms. We further linked these neural findings to the social context by demonstrating that greater self-reported relational peer victimization prospectively predicted AIN global efficiency. Collectively, these findings situate the emergence of adolescent depressive symptoms as a confluence of brain organization properties, perceived social rejection, and individual differences in rumination.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101621"},"PeriodicalIF":4.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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