Pub Date : 2025-12-10DOI: 10.1016/j.dcn.2025.101652
Flora Faure , Julie Uchitel , Sara De Crescenzo , Andrea Edwards , Jérôme Baranger , Kelly Pammenter , Katharine Lee , Samuel Powell , Greg Smith , Olivier Baud , Robert Cooper , Lauren Saade , Alice Frérot , Valérie Biran , Topun Austin , Charlie Demené
The newborn infant, particularly those born preterm, is vulnerable to brain injury resulting in lifelong neurodevelopmental sequalae. Conventional structural brain imaging correlates poorly with later individual neurodevelopmental trajectories. Therefore, assessing brain integrity with functional (particularly functional connectivity (FC)) neuroimaging, would be beneficial, as studies showed correlation between early FC assessment and later neurodevelopmental outcomes. However, these tools are absent of neonatal clinical settings, probably either due to lack of portability or restricted access to the deep structures. In this proof of concept (poc) work, we show that functional ultrasound imaging (fUS) has key characteristics for this challenge: including portability, sensitivity and spatiotemporal resolution. fUS can monitor fine grain brain activity in deep cerebral nuclei, detect changes in FC dynamics at different developmental stages, with capabilities for 3D imaging. Furthermore, we present a multimodal poc combining fUS with high-density diffuse optical tomography (HD-DOT). The results demonstrate correlation between fUS and HD-DOT signals in spatially overlapping areas of the brain. The complementary fields of view of fUS (in depth) and HD-DOT (shallow cortex) could enable for the first time cot-side whole brain assessment of FC. In the future, a system combining fUS and HD-DOT could be developed as a clinical tool to monitor the developing brain in high-risk infants.
{"title":"Cot-side functional imaging in neonates for early neurodevelopment monitoring using functional ultrasound (fUS) connectivity imaging and the combination of fUS with diffuse optical tomography (fUS-DOT): A feasibility study","authors":"Flora Faure , Julie Uchitel , Sara De Crescenzo , Andrea Edwards , Jérôme Baranger , Kelly Pammenter , Katharine Lee , Samuel Powell , Greg Smith , Olivier Baud , Robert Cooper , Lauren Saade , Alice Frérot , Valérie Biran , Topun Austin , Charlie Demené","doi":"10.1016/j.dcn.2025.101652","DOIUrl":"10.1016/j.dcn.2025.101652","url":null,"abstract":"<div><div>The newborn infant, particularly those born preterm, is vulnerable to brain injury resulting in lifelong neurodevelopmental sequalae. Conventional structural brain imaging correlates poorly with later individual neurodevelopmental trajectories. Therefore, assessing brain integrity with functional (particularly functional connectivity (FC)) neuroimaging, would be beneficial, as studies showed correlation between early FC assessment and later neurodevelopmental outcomes. However, these tools are absent of neonatal clinical settings, probably either due to lack of portability or restricted access to the deep structures. In this proof of concept (poc) work, we show that functional ultrasound imaging (fUS) has key characteristics for this challenge: including portability, sensitivity and spatiotemporal resolution. fUS can monitor fine grain brain activity in deep cerebral nuclei, detect changes in FC dynamics at different developmental stages, with capabilities for 3D imaging. Furthermore, we present a multimodal poc combining fUS with high-density diffuse optical tomography (HD-DOT). The results demonstrate correlation between fUS and HD-DOT signals in spatially overlapping areas of the brain. The complementary fields of view of fUS (in depth) and HD-DOT (shallow cortex) could enable for the first time cot-side whole brain assessment of FC. In the future, a system combining fUS and HD-DOT could be developed as a clinical tool to monitor the developing brain in high-risk infants.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101652"},"PeriodicalIF":4.9,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-07DOI: 10.1016/j.dcn.2025.101656
Liam R. Chawner, Sayaka Kidby, Arkadij Lobov, Alejandra Sel, Maria L. Filippetti
Emotional Eating (EE) behaviours may emerge throughout childhood as a function of maladaptive interoceptive abilities, where eating occurs in response to emotional states rather than to satisfy hunger signals. Genetic and neurobiological factors contribute to EE, indicating that underlying neural mechanisms may precede the manifestation of these behaviours. We examined the neural processes associated with the early development of EE. Twelve-month-old infants attended the lab and ate lunch until satiation before being exposed to a frustration-inducing task. While wearing an EEG cap, infants viewed pictures of liked foods and non-foods. We measured infants’ behavioural reactivity to the frustration task, Frontal Alpha Asymmetry (FAA) indicating approach-avoidance responses to food and non-food stimuli, and collected parent-reported data on infant appetitive traits and temperament, and feeding practices. At low levels of emotional reactivity to frustration, infants showed more approach to non-food stimuli, whereas for some infants with higher emotional reactivity, stronger FAA approach activity was observed towards food stimuli. Additionally, parental use of feeding to regulate emotions predicted higher FAA approach responses to both food and non-food stimuli. These results suggest that infants’ neural responses to a change in emotional state are associated with approach-avoidance tendencies towards food and non-food stimuli, before EE behaviours emerge. However, associations between food approach tendencies and parental influences at 12months remain unclear.
{"title":"Neural basis of approach and avoidance responses to food in 12-month-old infants following emotional state changes","authors":"Liam R. Chawner, Sayaka Kidby, Arkadij Lobov, Alejandra Sel, Maria L. Filippetti","doi":"10.1016/j.dcn.2025.101656","DOIUrl":"10.1016/j.dcn.2025.101656","url":null,"abstract":"<div><div>Emotional Eating (EE) behaviours may emerge throughout childhood as a function of maladaptive interoceptive abilities, where eating occurs in response to emotional states rather than to satisfy hunger signals. Genetic and neurobiological factors contribute to EE, indicating that underlying neural mechanisms may precede the manifestation of these behaviours. We examined the neural processes associated with the early development of EE. Twelve-month-old infants attended the lab and ate lunch until satiation before being exposed to a frustration-inducing task. While wearing an EEG cap, infants viewed pictures of liked foods and non-foods. We measured infants’ behavioural reactivity to the frustration task, Frontal Alpha Asymmetry (FAA) indicating approach-avoidance responses to food and non-food stimuli, and collected parent-reported data on infant appetitive traits and temperament, and feeding practices. At low levels of emotional reactivity to frustration, infants showed more approach to non-food stimuli, whereas for some infants with higher emotional reactivity, stronger FAA approach activity was observed towards food stimuli. Additionally, parental use of feeding to regulate emotions predicted higher FAA approach responses to both food and non-food stimuli. These results suggest that infants’ neural responses to a change in emotional state are associated with approach-avoidance tendencies towards food and non-food stimuli, before EE behaviours emerge. However, associations between food approach tendencies and parental influences at 12months remain unclear.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101656"},"PeriodicalIF":4.9,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1016/j.dcn.2025.101653
Marybel R. Gonzalez , Ty Brumback , Madison K. Wickershiem , Edith V. Sullivan , Adolf Pfefferbaum , Duncan B. Clark , David B. Goldston , M.J. Meloy , Firas Naber , Eva M. Müller-Oehring , Angelica M. Morales , Fiona C. Baker , Kate B. Nooner , Bonnie J. Nagel , Kilian M. Pohl , Kenneth J. Sher , Sandra A. Brown , Susan F. Tapert , Wesley K. Thompson
Adolescence through young adulthood is a sensitive neurodevelopmental window characterized by ongoing maturation of gray and white matter and heightened vulnerability to alcohol’s neurotoxic effects. Although prior studies link binge drinking with disrupted brain development, the potential for recovery with reduced alcohol use remains underexplored. Using data from 690 participants (ages 12–29) in the National Consortium on Alcohol and NeuroDevelopment in Adolescence to Adulthood (NCANDA-A), we examined the longitudinal impact of binge drinking episodes, and reductions in binge drinking episodes, on regional gray and white matter volumes. Linear mixed-effects models assessed (1) past-year binge drinking frequency, (2) reductions below personal mean binge drinking across time, and (3) transitions in frequency of binge drinking across 10 annual neuroimaging assessments. Results showed that higher binge drinking frequency was associated with decreases in gray matter across frontal, parietal, temporal, and occipital cortices, as well as white matter reductions in frontolimbic and frontostriatal pathways. Reductions below personal mean drinking frequency were also associated with attenuated shrinkage in gray matter volumes. Participants who transitioned from frequent to infrequent binge drinking had significantly larger corpus callosum volumes compared to those with sustained frequent binge episodes. This longitudinal analysis demonstrates consistent negative effects of binge drinking on gray and white matter regions. Importantly, reductions in binge drinking provide evidence for neuroanatomical recovery, particularly in the corpus callosum, and suggest that the degree of recovery may vary by brain region and extent of alcohol use reduction during this key developmental period.
{"title":"Structural brain recovery following reductions in adolescent and young adult binge drinking: A longitudinal NCANDA study","authors":"Marybel R. Gonzalez , Ty Brumback , Madison K. Wickershiem , Edith V. Sullivan , Adolf Pfefferbaum , Duncan B. Clark , David B. Goldston , M.J. Meloy , Firas Naber , Eva M. Müller-Oehring , Angelica M. Morales , Fiona C. Baker , Kate B. Nooner , Bonnie J. Nagel , Kilian M. Pohl , Kenneth J. Sher , Sandra A. Brown , Susan F. Tapert , Wesley K. Thompson","doi":"10.1016/j.dcn.2025.101653","DOIUrl":"10.1016/j.dcn.2025.101653","url":null,"abstract":"<div><div>Adolescence through young adulthood is a sensitive neurodevelopmental window characterized by ongoing maturation of gray and white matter and heightened vulnerability to alcohol’s neurotoxic effects. Although prior studies link binge drinking with disrupted brain development, the potential for recovery with reduced alcohol use remains underexplored. Using data from 690 participants (ages 12–29) in the National Consortium on Alcohol and NeuroDevelopment in Adolescence to Adulthood (NCANDA-A), we examined the longitudinal impact of binge drinking episodes, and reductions in binge drinking episodes, on regional gray and white matter volumes. Linear mixed-effects models assessed (1) past-year binge drinking frequency, (2) reductions below personal mean binge drinking across time, and (3) transitions in frequency of binge drinking across 10 annual neuroimaging assessments. Results showed that higher binge drinking frequency was associated with decreases in gray matter across frontal, parietal, temporal, and occipital cortices, as well as white matter reductions in frontolimbic and frontostriatal pathways. Reductions below personal mean drinking frequency were also associated with attenuated shrinkage in gray matter volumes. Participants who transitioned from frequent to infrequent binge drinking had significantly larger corpus callosum volumes compared to those with sustained frequent binge episodes. This longitudinal analysis demonstrates consistent negative effects of binge drinking on gray and white matter regions. Importantly, reductions in binge drinking provide evidence for neuroanatomical recovery, particularly in the corpus callosum, and suggest that the degree of recovery may vary by brain region and extent of alcohol use reduction during this key developmental period.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101653"},"PeriodicalIF":4.9,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human social interaction relies on the ability to detect and predict the temporal organization of sensory events. Although these abilities change markedly across infancy, little is known about their underlying neural mechanisms. This systematic review aims to define the neural signatures of temporal prediction in newborns and infants and to identify gaps that should guide future longitudinal research. Eight peer-reviewed studies were included, with 228 infants from birth to 9 months of age. Across studies, neural signatures of temporal prediction have been reported in broad cortical areas, including the anterior and medial parts of the brain, particularly within the frontal and central regions. Current evidence suggests that infants' neural responses to temporal regularities likely reflect a combination of early sensory-driven responses and emerging top-down processes. Importantly, gaps in the literature highlight the need for systematic, longitudinal approaches to clarify how neural mechanisms of temporal prediction develop and how biological predispositions and early experiences, including rhythmic and musical interactions, may contribute to this trajectory.
{"title":"The origins of time: A systematic review of the neural signatures of temporal prediction in infancy","authors":"Isabelle Rambosson , Damien Benis , Claire Kabdebon , Didier Grandjean , Manuela Filippa","doi":"10.1016/j.dcn.2025.101655","DOIUrl":"10.1016/j.dcn.2025.101655","url":null,"abstract":"<div><div>Human social interaction relies on the ability to detect and predict the temporal organization of sensory events. Although these abilities change markedly across infancy, little is known about their underlying neural mechanisms. This systematic review aims to define the neural signatures of temporal prediction in newborns and infants and to identify gaps that should guide future longitudinal research. Eight peer-reviewed studies were included, with 228 infants from birth to 9 months of age. Across studies, neural signatures of temporal prediction have been reported in broad cortical areas, including the anterior and medial parts of the brain, particularly within the frontal and central regions. Current evidence suggests that infants' neural responses to temporal regularities likely reflect a combination of early sensory-driven responses and emerging top-down processes. Importantly, gaps in the literature highlight the need for systematic, longitudinal approaches to clarify how neural mechanisms of temporal prediction develop and how biological predispositions and early experiences, including rhythmic and musical interactions, may contribute to this trajectory.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101655"},"PeriodicalIF":4.9,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-03DOI: 10.1016/j.dcn.2025.101654
Sagana Vijayarajah, Margaret L. Schlichting
Memory precision varies along the hippocampal long axis in the mature brain. Yet, little is known about how the development of long-axis functionality influences this precision. We characterized how children and adults engage the long axis to form precise memories. Children (7–9 years) and adults performed two tasks that encouraged an orientation to specific details versus general scene categories during encoding. After, they performed a recognition test with studied scenes and yoked lures. Adults had more precise memories than children in that they better discriminated studied scenes from lures. Yet, both groups showed memory benefits after orienting to specifics. Examining hippocampal engagement revealed that the two age groups relied on different subregions during specific encoding, with children recruiting the posterior third and adults the anterior third. Engagement was also differently related to memory quality. While the posterior third supported subsequent memory across age groups, both anterior and posterior thirds showed developmental differences in how they encouraged false memories—reflective of mnemonic breadth. Individual differences in the source of specific encoding along the long axis revealed that premature shifts towards an adult-like profile were disadvantageous to children’s memory. Our results suggest as development unfolds, refinements to the functionality of the entire long axis supports memory imprecision.
{"title":"Developmental differences in hippocampal long-axis contributions to memory precision","authors":"Sagana Vijayarajah, Margaret L. Schlichting","doi":"10.1016/j.dcn.2025.101654","DOIUrl":"10.1016/j.dcn.2025.101654","url":null,"abstract":"<div><div>Memory precision varies along the hippocampal long axis in the mature brain. Yet, little is known about how the development of long-axis functionality influences this precision. We characterized how children and adults engage the long axis to form precise memories. Children (7–9 years) and adults performed two tasks that encouraged an orientation to specific details versus general scene categories during encoding. After, they performed a recognition test with studied scenes and yoked lures. Adults had more precise memories than children in that they better discriminated studied scenes from lures. Yet, both groups showed memory benefits after orienting to specifics. Examining hippocampal engagement revealed that the two age groups relied on different subregions during specific encoding, with children recruiting the posterior third and adults the anterior third. Engagement was also differently related to memory quality. While the posterior third supported subsequent memory across age groups, both anterior and posterior thirds showed developmental differences in how they encouraged false memories—reflective of mnemonic breadth. Individual differences in the source of specific encoding along the long axis revealed that premature shifts towards an adult-like profile were disadvantageous to children’s memory. Our results suggest as development unfolds, refinements to the functionality of the entire long axis supports memory imprecision.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101654"},"PeriodicalIF":4.9,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.dcn.2025.101648
Katherine S.F. Damme , Teresa G. Vargas , Julia A. Bauer
Background
Global warming, urbanization, coal-burning pollution, and global wildfires draw attention to the necessity of bridging gaps in our current understanding of the effects of fine particulate matter (PM2.5) on neurodevelopment. Despite evidence of environmental contaminants having deleterious effects on cognition and neurodevelopment in particularly sensitive areas like the hippocampus that have prolonged plasticity, much of this work examines a single time point (e.g., prenatal exposure) in single site studies. As a result, it is unclear whether deleterious effects accumulate over development.
Methods
The Adolescent Brain Cognitive Development study (aged 8.9–11.1 years; 47.1 % female) provides a geographically broad and racially diverse sample (66.1 % White, 20.7 % Black, 13.2 % Multiple/Other). This study also includes prenatal and late childhood measures of PM2.5 and ozone (O3) as well as hippocampal volume (n = 6553), hippocampal function (n = 5556), and related cognition (n = 6418).
Results
Adjusted associations of PM2.5 exposure were associated with smaller hippocampal volumes and less accurate working memory performance; this association was stronger for youth exposed to relatively higher PM2.5 during both prenatal and late childhood periods as compared to lower PM2.5 categories.
Conclusions
Results support exposure to PM2.5 during prenatal and late childhood periods could have cumulative links to altered neural structure and executive function during sensitive periods of development. Study findings could inform physical environment health promoting prevention and intervention policy efforts.
{"title":"The cumulative impact of fine particulate matter exposure on hippocampal volume and working memory: Insights from prenatal and adolescent exposures from the ABCD study.","authors":"Katherine S.F. Damme , Teresa G. Vargas , Julia A. Bauer","doi":"10.1016/j.dcn.2025.101648","DOIUrl":"10.1016/j.dcn.2025.101648","url":null,"abstract":"<div><h3>Background</h3><div>Global warming, urbanization, coal-burning pollution, and global wildfires draw attention to the necessity of bridging gaps in our current understanding of the effects of fine particulate matter (PM<sub>2.5</sub>) on neurodevelopment. Despite evidence of environmental contaminants having deleterious effects on cognition and neurodevelopment in particularly sensitive areas like the hippocampus that have prolonged plasticity, much of this work examines a single time point (e.g., prenatal exposure) in single site studies. As a result, it is unclear whether deleterious effects accumulate over development.</div></div><div><h3>Methods</h3><div>The Adolescent Brain Cognitive Development study (aged 8.9–11.1 years; 47.1 % female) provides a geographically broad and racially diverse sample (66.1 % White, 20.7 % Black, 13.2 % Multiple/Other). This study also includes prenatal and late childhood measures of PM<sub>2.5</sub> and ozone (O<sup>3</sup>) as well as hippocampal volume (n = 6553), hippocampal function (n = 5556), and related cognition (n = 6418).</div></div><div><h3>Results</h3><div>Adjusted associations of PM<sub>2.5</sub> exposure were associated with smaller hippocampal volumes and less accurate working memory performance; this association was stronger for youth exposed to relatively higher PM<sub>2.5</sub> during both prenatal and late childhood periods as compared to lower PM<sub>2.5</sub> categories.</div></div><div><h3>Conclusions</h3><div>Results support exposure to PM<sub>2.5</sub> during prenatal and late childhood periods could have cumulative links to altered neural structure and executive function during sensitive periods of development. Study findings could inform physical environment health promoting prevention and intervention policy efforts.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101648"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.dcn.2025.101627
Margaret A. Sheridan , Brenden Tervo-Clemmens , Ece Demir-Lira , Anthony Steven Dick , Jamie L. Hanson , Leah H. Somerville , Chad M. Sylvester , Moriah E. Thomason , Sarah Whittle , Deanna M. Barch , Beatriz Luna
{"title":"Advances on design considerations in Developmental Cognitive Neuroscience","authors":"Margaret A. Sheridan , Brenden Tervo-Clemmens , Ece Demir-Lira , Anthony Steven Dick , Jamie L. Hanson , Leah H. Somerville , Chad M. Sylvester , Moriah E. Thomason , Sarah Whittle , Deanna M. Barch , Beatriz Luna","doi":"10.1016/j.dcn.2025.101627","DOIUrl":"10.1016/j.dcn.2025.101627","url":null,"abstract":"","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"76 ","pages":"Article 101627"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1016/j.dcn.2025.101647
Elmehdi Hamouda , Wei Mao , Dan Xu , Keith Kendrick , Xi Jiang
Preterm birth disrupts the gyrification process during the third trimester of pregnancy. Meanwhile, accumulating studies have highlighted the significant structural and functional differences between the folding patterns of cortical gyri and sulci, suggesting that they may play distinct roles in brain function. This study aimed to explore how preterm birth influences the structural and functional patterns of gyral and sulcal regions. Using a Developing Human Connectome Project (dHCP) open dataset including both full-term and preterm neonates (207 subjects), we parcellated each brain region into gyri and sulci based on the vertex curvature values. Structural connectivity was assessed via diffusion MRI (dMRI) images, and functional differences via fMRI BOLD signals using synchronization measures, nodal degree, and network-based statistics (NBS). Findings revealed that preterm birth reduces structural connectivity between gyri and lowers the ratio of intra-gyri/gyri-sulci connections. This ratio was significantly associated with gestational age, birth weight, and global synchronization. NBS analysis revealed a cluster of hypo-connections, mostly gyri-to-sulci connections. Overall, results suggest that preterm birth affects gyri and sulci differently, potentially disrupting their distinct functional roles, and offering new insights into prematurity’s impact on brain function.
{"title":"Preterm birth differentially impacts structural and functional connectivity of cortical gyri and sulci","authors":"Elmehdi Hamouda , Wei Mao , Dan Xu , Keith Kendrick , Xi Jiang","doi":"10.1016/j.dcn.2025.101647","DOIUrl":"10.1016/j.dcn.2025.101647","url":null,"abstract":"<div><div>Preterm birth disrupts the gyrification process during the third trimester of pregnancy. Meanwhile, accumulating studies have highlighted the significant structural and functional differences between the folding patterns of cortical gyri and sulci, suggesting that they may play distinct roles in brain function. This study aimed to explore how preterm birth influences the structural and functional patterns of gyral and sulcal regions. Using a Developing Human Connectome Project (dHCP) open dataset including both full-term and preterm neonates (207 subjects), we parcellated each brain region into gyri and sulci based on the vertex curvature values. Structural connectivity was assessed via diffusion MRI (dMRI) images, and functional differences via fMRI BOLD signals using synchronization measures, nodal degree, and network-based statistics (NBS). Findings revealed that preterm birth reduces structural connectivity between gyri and lowers the ratio of intra-gyri/gyri-sulci connections. This ratio was significantly associated with gestational age, birth weight, and global synchronization. NBS analysis revealed a cluster of hypo-connections, mostly gyri-to-sulci connections. Overall, results suggest that preterm birth affects gyri and sulci differently, potentially disrupting their distinct functional roles, and offering new insights into prematurity’s impact on brain function.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101647"},"PeriodicalIF":4.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.dcn.2025.101645
Yiyi Wang , Marc Colomer , Hyesung Grace Hwang , Enda Tan , Nathan A. Fox , Amanda Woodward
What language a person speaks has been shown to divide even infants' worlds. However, open questions remain about what neural processes are involved in the differentiation of native and foreign speakers in the infant's brain. This study used electroencephalography (EEG) to examine the neural responses related to top-down attention (frontal theta synchronization), action processing (mu desynchronization), and approach-avoidance (frontal alpha asymmetry) of 8- to 12-month-old infants as they observed a native (English) speaker and a foreign (French) speaker perform a goal-directed action (i.e., grasping objects). We further examined whether infants’ language exposure modulated these neural responses. We found that monolingual infants exhibited stronger mu desynchronization when observing a native (versus foreign) speaker perform goal-directed actions. In contrast, non-monolingual (i.e., hearing more than one language) infants did not show a difference in mu desynchronization between native and foreign speakers. No language group and exposure effects were found for frontal theta and frontal alpha symmetry. These results suggest that infants’ emerging differentiation of native and foreign speakers is also manifested in their neural processing of goal-directed actions and that this neural action processing is shaped by early exposure to different languages.
{"title":"Language exposure predicts infants’ neural processing of others’ actions based on language group","authors":"Yiyi Wang , Marc Colomer , Hyesung Grace Hwang , Enda Tan , Nathan A. Fox , Amanda Woodward","doi":"10.1016/j.dcn.2025.101645","DOIUrl":"10.1016/j.dcn.2025.101645","url":null,"abstract":"<div><div>What language a person speaks has been shown to divide even infants' worlds. However, open questions remain about what neural processes are involved in the differentiation of native and foreign speakers in the infant's brain. This study used electroencephalography (EEG) to examine the neural responses related to top-down attention (frontal theta synchronization), action processing (mu desynchronization), and approach-avoidance (frontal alpha asymmetry) of 8- to 12-month-old infants as they observed a native (English) speaker and a foreign (French) speaker perform a goal-directed action (i.e., grasping objects). We further examined whether infants’ language exposure modulated these neural responses. We found that monolingual infants exhibited stronger mu desynchronization when observing a native (versus foreign) speaker perform goal-directed actions. In contrast, non-monolingual (i.e., hearing more than one language) infants did not show a difference in mu desynchronization between native and foreign speakers. No language group and exposure effects were found for frontal theta and frontal alpha symmetry. These results suggest that infants’ emerging differentiation of native and foreign speakers is also manifested in their neural processing of goal-directed actions and that this neural action processing is shaped by early exposure to different languages.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101645"},"PeriodicalIF":4.9,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adolescent adversity could have lasting effects on mental health, potentially through neurodevelopmental changes. This study used a random intercept cross-lagged panel model to examine how adverse experiences, brain development, and behavioural and emotional problems are linked over time in the ABCD study (N ≈ 12.000, USA). We found a positive association between family conflict and behavioural and emotional problems: family conflict was related to increased problems at 10 – 12 years (β = 0.06, p = 0.002), and vice versa. At 12 – 14 years, behavioural and emotional problems were also related to increased family conflict (β = 0.20, p < 0.001). Neighbourhood perception was related to behavioural and emotional problems and white matter microstructure. At 10 – 12 years, low neighbourhood safety was related to lower levels of white matter microstructure (β = −0.04, p = 0.041) and vice versa. It was also associated with more behavioural and emotional problems (β = 0.05, p = 0.015) and vice versa. Behavioural and emotional problems were positively associated with neighbourhood perception for adolescents with more friends (χ²(1) = 9.82, pBonf. = 0.02). These findings underscore the need to consider socio-environmental adversity when examining adolescent brain development and mental health.
青春期的逆境可能会对心理健康产生持久的影响，可能是通过神经发育的变化。本研究使用随机截距交叉滞后面板模型来研究ABCD研究中不良经历、大脑发育、行为和情绪问题如何随时间联系在一起（N ≈ 12.000，美国）。我们发现家庭冲突与行为和情绪问题之间存在正相关关系：家庭冲突与10 - 12岁的问题增加有关（β = 0.06, p = 0.002），反之亦然。在12 - 14岁时，行为和情绪问题也与家庭冲突增加有关（β = 0.20, p <； 0.001）。邻里感知与行为、情绪问题和白质微观结构有关。在10 ~ 12岁时，低邻里安全与较低的白质微结构水平相关（β = - 0.04, p = 0.041），反之亦然。它还与更多的行为和情绪问题相关（β = 0.05, p = 0.015），反之亦然。对于朋友较多的青少年，行为和情绪问题与邻里感知呈正相关(χ²(1)= 9.82,pBonf。= 0.02)。这些发现强调了在检查青少年大脑发育和心理健康时考虑社会环境逆境的必要性。
{"title":"Longitudinal associations between adolescent adversity, brain development and behavioural and emotional problems","authors":"Ayla Pollmann , Divyangana Rakesh , Delia Fuhrmann","doi":"10.1016/j.dcn.2025.101646","DOIUrl":"10.1016/j.dcn.2025.101646","url":null,"abstract":"<div><div>Adolescent adversity could have lasting effects on mental health, potentially through neurodevelopmental changes. This study used a random intercept cross-lagged panel model to examine how adverse experiences, brain development, and behavioural and emotional problems are linked over time in the ABCD study (N ≈ 12.000, USA). We found a positive association between family conflict and behavioural and emotional problems: family conflict was related to increased problems at 10 – 12 years (β = 0.06, p = 0.002), and vice versa. At 12 – 14 years, behavioural and emotional problems were also related to increased family conflict (β = 0.20, p < 0.001). Neighbourhood perception was related to behavioural and emotional problems and white matter microstructure. At 10 – 12 years, low neighbourhood safety was related to lower levels of white matter microstructure (β = −0.04, p = 0.041) and vice versa. It was also associated with more behavioural and emotional problems (β = 0.05, p = 0.015) and vice versa. Behavioural and emotional problems were positively associated with neighbourhood perception for adolescents with more friends (χ²(1) = 9.82, p<sub>Bonf.</sub> = 0.02). These findings underscore the need to consider socio-environmental adversity when examining adolescent brain development and mental health.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"77 ","pages":"Article 101646"},"PeriodicalIF":4.9,"publicationDate":"2025-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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