Pub Date : 2024-03-21DOI: 10.1016/j.bjorl.2024.101425
Filip Tudor , Andro Košec , Alan Pegan
{"title":"Internal jugular vein thrombosis caused by invasive pharyngeal cancer: a case report and literature review","authors":"Filip Tudor , Andro Košec , Alan Pegan","doi":"10.1016/j.bjorl.2024.101425","DOIUrl":"10.1016/j.bjorl.2024.101425","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000405/pdfft?md5=01cc5e9cd31c11131799246c293265d6&pid=1-s2.0-S1808869424000405-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140281163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study is to investigate the lung function in Chronic Rhinosinusitis (CRS) patients with Chronic Cough (CC).
Methods
A total of 1413 CC patients were retrospectively screened and 109 CRS patients with CC were enrolled. Lung function, Lund-Mackay Computed Tomography (CT) score, smoking status, peripheral blood eosinophil count, and immunoglobulin E concentration in serum samples, and Sino-Nasal Outcome Test were examined. Normal control subjects are also recruited.
Results
The Forced Expiratory Volume in 1 second (FEV1.0), Percent Predicted FEV1.0, and FEV1.0/Forced Vital Capacity (FVC) ratio in the patients were significantly low as compared with the control subjects. The FEV1.0/FVC ratio was negatively correlated with the Lund-Mackay CT scores of the patients with a high CT score.
Conclusions
The CRS patients with CC should be investigated with lung function. In addition, the multidisciplinary evaluation including a pulmonologist is needed to manage the CRS patients with CC.
Level of evidence
Level 4.
方法 对 1413 名慢性鼻窦炎（CRS）患者进行回顾性筛查，并纳入 109 名慢性鼻窦炎（CRS）合并慢性咳嗽（CC）患者。方法 对 1413 名 CC 患者进行回顾性筛选，并纳入 109 名 CRS CC 患者，对他们的肺功能、Lund-Mackay 计算机断层扫描（CT）评分、吸烟状况、外周血嗜酸性粒细胞计数、血清样本中免疫球蛋白 E 的浓度以及中鼻结果测试进行检查。结果与对照组相比，患者的 1 秒用力呼气容积（FEV1.0）、预测 FEV1.0 百分比和 FEV1.0/ 强迫生命容量（FVC）比值明显偏低。FEV1.0/FVC比值与CT评分高的患者的Lund-Mackay CT评分呈负相关。此外，还需要进行包括肺科医生在内的多学科评估，以管理伴有 CC 的 CRS 患者。
{"title":"Chronic rhinosinusitis possibly associated with decreased lung function in chronic cough patients","authors":"Pengfei Zhao , Shin Kariya , Takaya Higaki , Seiichiro Makihara , Toru Rikimaru , Mitsuhiro Okano , Mizuo Ando","doi":"10.1016/j.bjorl.2024.101424","DOIUrl":"10.1016/j.bjorl.2024.101424","url":null,"abstract":"<div><h3>Objectives</h3><p>The purpose of this study is to investigate the lung function in Chronic Rhinosinusitis (CRS) patients with Chronic Cough (CC).</p></div><div><h3>Methods</h3><p>A total of 1413 CC patients were retrospectively screened and 109 CRS patients with CC were enrolled. Lung function, Lund-Mackay Computed Tomography (CT) score, smoking status, peripheral blood eosinophil count, and immunoglobulin E concentration in serum samples, and Sino-Nasal Outcome Test were examined. Normal control subjects are also recruited.</p></div><div><h3>Results</h3><p>The Forced Expiratory Volume in 1 second (FEV<sub>1.0</sub>), Percent Predicted FEV<sub>1.0</sub>, and FEV<sub>1.0</sub>/Forced Vital Capacity (FVC) ratio in the patients were significantly low as compared with the control subjects. The FEV<sub>1.0</sub>/FVC ratio was negatively correlated with the Lund-Mackay CT scores of the patients with a high CT score.</p></div><div><h3>Conclusions</h3><p>The CRS patients with CC should be investigated with lung function. In addition, the multidisciplinary evaluation including a pulmonologist is needed to manage the CRS patients with CC.</p></div><div><h3>Level of evidence</h3><p>Level 4.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000399/pdfft?md5=3d0be4a5955f4c8b6dadc16514180564&pid=1-s2.0-S1808869424000399-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-07DOI: 10.1016/j.bjorl.2024.101411
Nimei Shen , Gang Gao , Xinhong Lu, Jiaxin Jin, Liwei Lin, Maohua Qian, Yang Qin
Objectives
The role of Epoxide Hydrolase-4 (EPHX4), a member of epoxide hydrolase family, has not been investigated in cancer. The purpose of this article is to explore the application value of EPHX4 in laryngeal cancer and its relationship with immune infiltration.
Methods
We observed that EPHX4 expression and its survival assays in laryngeal cancer specimens based on The Cancer Genome Atlas (TCGA) cohorts. We also analyzed the correlation between immune cell infiltration levels and EPHX4 gene copy number in laryngeal cancer. Finally, we conducted in vitro assay to evaluate the functions of EPHX4 in laryngeal cancer cell line.
Results
EPHX4 is highly expressed in laryngeal cancer specimens and has a poor prognosis. EPHX4 related immune cell analysis showed that it participated in NK Natural killer cell mediated cytotoxicity. Finally, Cell experiments indicate that EPHX4 could promote laryngeal cancer cell line proliferation, colony formation and invasion.
Conclusions
Our research results suggest that EPHX4 may be a potential immunotherapy target for laryngeal cancer. The nominated immune signature is a helpful and promising prognostic indicator in laryngeal cancer.
{"title":"Comprehensive analysis of the immune implication of EPHX4 gene in laryngeal squamous cell carcinoma","authors":"Nimei Shen , Gang Gao , Xinhong Lu, Jiaxin Jin, Liwei Lin, Maohua Qian, Yang Qin","doi":"10.1016/j.bjorl.2024.101411","DOIUrl":"10.1016/j.bjorl.2024.101411","url":null,"abstract":"<div><h3>Objectives</h3><p>The role of Epoxide Hydrolase-4 (EPHX4), a member of epoxide hydrolase family, has not been investigated in cancer. The purpose of this article is to explore the application value of EPHX4 in laryngeal cancer and its relationship with immune infiltration.</p></div><div><h3>Methods</h3><p>We observed that EPHX4 expression and its survival assays in laryngeal cancer specimens based on The Cancer Genome Atlas (TCGA) cohorts. We also analyzed the correlation between immune cell infiltration levels and EPHX4 gene copy number in laryngeal cancer. Finally, we conducted in vitro assay to evaluate the functions of EPHX4 in laryngeal cancer cell line.</p></div><div><h3>Results</h3><p>EPHX4 is highly expressed in laryngeal cancer specimens and has a poor prognosis. EPHX4 related immune cell analysis showed that it participated in NK Natural killer cell mediated cytotoxicity. Finally, Cell experiments indicate that EPHX4 could promote laryngeal cancer cell line proliferation, colony formation and invasion.</p></div><div><h3>Conclusions</h3><p>Our research results suggest that EPHX4 may be a potential immunotherapy target for laryngeal cancer. The nominated immune signature is a helpful and promising prognostic indicator in laryngeal cancer.</p></div><div><h3>Levels of Evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000260/pdfft?md5=f5082510a8df9f5ecbd2384820688771&pid=1-s2.0-S1808869424000260-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.1016/j.bjorl.2024.101414
Elif Sarı , Gkionoul Nteli Chatzioglou , Dastan Temirbekov , Aynur Aliyeva , Adnan Öztürk , Ilke Ali Gürses
Objectives
The internal acoustic meatus is an osseous canal that connects the inner ear to the posterior cranial fossa. It is located in the petrous portion of the temporal bone. A thin cribriform osseous plate known as the fundus is situated at the lateral end of the canal. This study assesses the structural and numerical variations of the fundus formations.
Methods
Fifty-four temporal bones of unknown gender and age were examined with the surgical microscope.
Results
The temporal bones analyzed were 46.2% right-sided and 53.7% left-sided. Only one temporal bone had two parallel transverse crests, while three had a single anterior crest that split into two branches posteriorly. The number of foramina at the transverse crest varied, with 29.6% having none, 48.1% having a single foramen, and 22.2% having several foramina. An anterior crest structure was seen in 53.7% of the temporal bones, with 5% having a slightly constricted entry to the facial canal. In cases with a single nerve foramen, 48.1% had one, while 51.8% had more than one, including examples with three or four foramina. A crest was found between the foramina of the single nerve in 7% of patients. Furthermore, a crest between the saccular nerve foramen and the high fiber foramina was seen in 25.9% of cases, and 5% had two saccular nerve foramina.
Conclusion
We think that revealing the anatomical, structural and numerical variations in the fundus will be useful in explaining the disease-symptom relationship.
{"title":"The variations of osseous structure of the ınternal acoustic canal: an anatomical study","authors":"Elif Sarı , Gkionoul Nteli Chatzioglou , Dastan Temirbekov , Aynur Aliyeva , Adnan Öztürk , Ilke Ali Gürses","doi":"10.1016/j.bjorl.2024.101414","DOIUrl":"10.1016/j.bjorl.2024.101414","url":null,"abstract":"<div><h3>Objectives</h3><p>The internal acoustic meatus is an osseous canal that connects the inner ear to the posterior cranial fossa. It is located in the petrous portion of the temporal bone. A thin cribriform osseous plate known as the fundus is situated at the lateral end of the canal. This study assesses the structural and numerical variations of the fundus formations.</p></div><div><h3>Methods</h3><p>Fifty-four temporal bones of unknown gender and age were examined with the surgical microscope.</p></div><div><h3>Results</h3><p>The temporal bones analyzed were 46.2% right-sided and 53.7% left-sided. Only one temporal bone had two parallel transverse crests, while three had a single anterior crest that split into two branches posteriorly. The number of foramina at the transverse crest varied, with 29.6% having none, 48.1% having a single foramen, and 22.2% having several foramina. An anterior crest structure was seen in 53.7% of the temporal bones, with 5% having a slightly constricted entry to the facial canal. In cases with a single nerve foramen, 48.1% had one, while 51.8% had more than one, including examples with three or four foramina. A crest was found between the foramina of the single nerve in 7% of patients. Furthermore, a crest between the saccular nerve foramen and the high fiber foramina was seen in 25.9% of cases, and 5% had two saccular nerve foramina.</p></div><div><h3>Conclusion</h3><p>We think that revealing the anatomical, structural and numerical variations in the fundus will be useful in explaining the disease-symptom relationship.</p></div><div><h3>Level of evidence</h3><p>Level 4.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000296/pdfft?md5=4267f56f8176c11ef7bbf50f3bff7681&pid=1-s2.0-S1808869424000296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140056637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1016/j.bjorl.2024.101413
Xin-ke Wang , Qi-ling Zheng , Jia-ning Sun
Objective
A retrospective analysis was performed to explore the clinical effect of the Posterior Nasal Nerve (PNN) resection combined with hormone transnasal nebulization on Difficult-to-Treat Rhinosinusitis (DTRS).
Methods
A total of 120 DTRS patients were selected and divided into a control group (n = 60) and a study group (n = 60) according to different treatments. The control group patients were treated via PNN resection, followed by normal saline transnasal nebulization; the study group patients were given PNN resection and then treated with budesonide suspension transnasal nebulization. Subsequently, the comparison was performed between the two groups in terms of (1) Clinical baseline characteristics; (2) Sino-nasal Outcome Test (SNOT)-22 scores before treatment and after 3-months, 6-months and 12-months of treatment; (3) Lund-MacKay scores before treatment and after 10, 30, 90, and 180 days of treatment; (4) Incidence of adverse reactions during treatment.
Results
There was no significant difference in SNOT-22 or Lund-Kennedy scores between the two groups before treatment (p > 0.05). After treatment, the SNOT-22 and Lund-Kennedy scores of the control and the study groups were decreased, and compared with the control group, the SNOT-22 and Lund-Kennedy scores in the study group improved more significantly (p < 0.05). In addition, the study group and the control group presented with 1 and 4 cases of nasal adhesion, 2 and 3 cases of epistaxis, 1 and 4 cases of sinus orifice obstruction, 1 and 3 cases of lacrimal duct injuries, respectively. The incidence of adverse reactions in the study group was significantly lower than that in the control group (8.3% vs. 23.3%) (p < 0.05).
Conclusion
PNN resection combined with hormone transnasal nebulization treatment can improve the symptoms and quality of life of DTRS patients, with good clinical efficacy but few adverse reactions. Therefore, such combination treatment deserves a promotion and application clinically.
{"title":"Efficacy of the posterior nasal nerve resection combined with hormone transnasal nebulization on difficult-to-treat rhinosinusitis: a retrospective analysis","authors":"Xin-ke Wang , Qi-ling Zheng , Jia-ning Sun","doi":"10.1016/j.bjorl.2024.101413","DOIUrl":"10.1016/j.bjorl.2024.101413","url":null,"abstract":"<div><h3>Objective</h3><p>A retrospective analysis was performed to explore the clinical effect of the Posterior Nasal Nerve (PNN) resection combined with hormone transnasal nebulization on Difficult-to-Treat Rhinosinusitis (DTRS).</p></div><div><h3>Methods</h3><p>A total of 120 DTRS patients were selected and divided into a control group (<em>n</em> = 60) and a study group (<em>n</em> = 60) according to different treatments. The control group patients were treated via PNN resection, followed by normal saline transnasal nebulization; the study group patients were given PNN resection and then treated with budesonide suspension transnasal nebulization. Subsequently, the comparison was performed between the two groups in terms of (1) Clinical baseline characteristics; (2) Sino-nasal Outcome Test (SNOT)-22 scores before treatment and after 3-months, 6-months and 12-months of treatment; (3) Lund-MacKay scores before treatment and after 10, 30, 90, and 180 days of treatment; (4) Incidence of adverse reactions during treatment.</p></div><div><h3>Results</h3><p>There was no significant difference in SNOT-22 or Lund-Kennedy scores between the two groups before treatment (<em>p</em> > 0.05). After treatment, the SNOT-22 and Lund-Kennedy scores of the control and the study groups were decreased, and compared with the control group, the SNOT-22 and Lund-Kennedy scores in the study group improved more significantly (<em>p</em> < 0.05). In addition, the study group and the control group presented with 1 and 4 cases of nasal adhesion, 2 and 3 cases of epistaxis, 1 and 4 cases of sinus orifice obstruction, 1 and 3 cases of lacrimal duct injuries, respectively. The incidence of adverse reactions in the study group was significantly lower than that in the control group (8.3% vs. 23.3%) (<em>p</em> < 0.05).</p></div><div><h3>Conclusion</h3><p>PNN resection combined with hormone transnasal nebulization treatment can improve the symptoms and quality of life of DTRS patients, with good clinical efficacy but few adverse reactions. Therefore, such combination treatment deserves a promotion and application clinically.</p></div><div><h3>Level of Evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000284/pdfft?md5=dd0d56463d474c5c472f5e5fe87c2b58&pid=1-s2.0-S1808869424000284-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140056636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1016/j.bjorl.2024.101410
Jingpu Yang , Chang Liu , Jinzhang Cheng , Yunmeng Wang , Zonggui Wang , Wei Zhong
Objective
Our aim in this study is to identify the core genes of chronic rhinosinusitis with nasal polyps and analyze the correlations between it and inflammation-related genes.
Methods
GSE72713 dataset containing gene expression data of ECRSwNP, nonECRSwNP and healthy samples was obtained from Gene Expression Omnibus (GEO) and filtered by limma to identify DEGs among three groups, then the functions and correlated pathways of DEGs were analyzed using GO and KEGG. The core DEGs were selected by the intersection of DEGs and the PPI network was constructed via STRING. The correlations between the expression levels of CRSwNP core gene and inflammation-related genes were analyzed via the Mann-Whitney U test.
Results
The DEGs among ECRSwNP, nonECRSwNP, and CTRL were filtered respectively, and enrichment analysis showed they were associated with olfaction and/or immune responses. The PPI network was constructed by 7 core DEGs obtained via the intersection among three groups, and ALOX15 was confirmed as the core gene in the network. Subsequently, the correlations between the expression levels of ALOX15 and inflammation-related genes were illustrated.
Conclusion
In this study, the core gene ALOX15 was selected from the DEGs among ECRSwNP, nonECRSwNP, and CTRL. IL5, IL1RL1, and IL1RAP were found to exhibit a significant positive correlation with ALOX15.
{"title":"Identification of core gene in chronic rhinosinusitis with nasal polyps and correlations with inflammation-related genes","authors":"Jingpu Yang , Chang Liu , Jinzhang Cheng , Yunmeng Wang , Zonggui Wang , Wei Zhong","doi":"10.1016/j.bjorl.2024.101410","DOIUrl":"10.1016/j.bjorl.2024.101410","url":null,"abstract":"<div><h3>Objective</h3><p>Our aim in this study is to identify the core genes of chronic rhinosinusitis with nasal polyps and analyze the correlations between it and inflammation-related genes.</p></div><div><h3>Methods</h3><p>GSE72713 dataset containing gene expression data of ECRSwNP, nonECRSwNP and healthy samples was obtained from Gene Expression Omnibus (GEO) and filtered by limma to identify DEGs among three groups, then the functions and correlated pathways of DEGs were analyzed using GO and KEGG. The core DEGs were selected by the intersection of DEGs and the PPI network was constructed via STRING. The correlations between the expression levels of CRSwNP core gene and inflammation-related genes were analyzed via the Mann-Whitney <em>U</em> test.</p></div><div><h3>Results</h3><p>The DEGs among ECRSwNP, nonECRSwNP, and CTRL were filtered respectively, and enrichment analysis showed they were associated with olfaction and/or immune responses. The PPI network was constructed by 7 core DEGs obtained via the intersection among three groups, and ALOX15 was confirmed as the core gene in the network. Subsequently, the correlations between the expression levels of ALOX15 and inflammation-related genes were illustrated.</p></div><div><h3>Conclusion</h3><p>In this study, the core gene ALOX15 was selected from the DEGs among ECRSwNP, nonECRSwNP, and CTRL. IL5, IL1RL1, and IL1RAP were found to exhibit a significant positive correlation with ALOX15.</p></div><div><h3>Level of Evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000259/pdfft?md5=9683e7d9e2a10845d8ae47076f3bfe2d&pid=1-s2.0-S1808869424000259-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140056642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1016/j.bjorl.2024.101415
Otavio B. Piltcher
{"title":"Chronic rhinosinusitis with nasal polyps: changing expectations","authors":"Otavio B. Piltcher","doi":"10.1016/j.bjorl.2024.101415","DOIUrl":"https://doi.org/10.1016/j.bjorl.2024.101415","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000302/pdfft?md5=e36fda10b6acefca096d807e1c5da8e3&pid=1-s2.0-S1808869424000302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1016/j.bjorl.2024.101412
Bernard Beraldin , Gustavo Rassier Isolan , Lucas Rodrigues Mostardeiro , Vagner Antonio Rodrigues Silva , Joel Lavinsky
Objective
To analyze variability in the distance between the Anterior Ethmoidal Artery (AEA) and the anterior Skull Base (SB), as well as the frequency of lateral asymmetry in a Latin American population using computed tomography.
Methods
A total of 250 computed tomography scans of paranasal sinuses in coronal reconstruction (500 AEAs) were analyzed. After determining the image with the best anatomical view of the artery, the distance between its midpoint and the ethmoidal roof was measured, and the images were independently interpreted by 2 physicians.
Results
Of the 500 AEAs, 279 (55.8%) adhered to or passed through the SB at a distance of 0 mm. A total of 221 AEAs (44.2%) were at some distance from the SB, of which 107 (48.4%) were on the right side, ranging from 1.18 to 6.75 mm, and 114 (51.5%) were on the left side, ranging from 1.15 to 6.04 mm. The overall mean distance between the AEA and SB was 1.22 (SD = 1.57) mm, increasing to 2.77 (SD = 1.14) when the arteries adhered to the SB were excluded. Seventy-six individuals (30.4%) had a lateral distance variation > 1 mm.
Conclusion
Our study includes the largest sample of AEA analyzed with computed tomography scans of paranasal sinuses. There was some distance between the AEA and SB in almost half the patients, and we found a high rate of lateral variability >1 mm.
{"title":"Asymmetry of the anterior ethmoidal artery in relation to the anterior skull base: a population-based study of 500 arteries","authors":"Bernard Beraldin , Gustavo Rassier Isolan , Lucas Rodrigues Mostardeiro , Vagner Antonio Rodrigues Silva , Joel Lavinsky","doi":"10.1016/j.bjorl.2024.101412","DOIUrl":"10.1016/j.bjorl.2024.101412","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze variability in the distance between the Anterior Ethmoidal Artery (AEA) and the anterior Skull Base (SB), as well as the frequency of lateral asymmetry in a Latin American population using computed tomography.</p></div><div><h3>Methods</h3><p>A total of 250 computed tomography scans of paranasal sinuses in coronal reconstruction (500 AEAs) were analyzed. After determining the image with the best anatomical view of the artery, the distance between its midpoint and the ethmoidal roof was measured, and the images were independently interpreted by 2 physicians.</p></div><div><h3>Results</h3><p>Of the 500 AEAs, 279 (55.8%) adhered to or passed through the SB at a distance of 0<!--> <!-->mm. A total of 221 AEAs (44.2%) were at some distance from the SB, of which 107 (48.4%) were on the right side, ranging from 1.18 to 6.75<!--> <!-->mm, and 114 (51.5%) were on the left side, ranging from 1.15 to 6.04<!--> <!-->mm. The overall mean distance between the AEA and SB was 1.22 (SD<!--> <!-->=<!--> <!-->1.57) mm, increasing to 2.77 (SD<!--> <!-->=<!--> <!-->1.14) when the arteries adhered to the SB were excluded. Seventy-six individuals (30.4%) had a lateral distance variation > 1<!--> <!-->mm.</p></div><div><h3>Conclusion</h3><p>Our study includes the largest sample of AEA analyzed with computed tomography scans of paranasal sinuses. There was some distance between the AEA and SB in almost half the patients, and we found a high rate of lateral variability >1<!--> <!-->mm.</p></div><div><h3>Level of evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000272/pdfft?md5=d1dbfed6b9c49ca5f714ea51db26a27f&pid=1-s2.0-S1808869424000272-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140056590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.1016/j.bjorl.2024.101409
Seyed-Morteza Javadirad
Objective
Nodular goiter may increase the risk of thyroid cancer, but the genetic factors contributing to nodular goiter are not well understood. There is an overexpression of H19 lncRNA in goiter tissue and its target remains unknown. In this study, we attempted to identify a new target for H19 in the context of goiter development.
Methods
Using interaction energy calculations, the interaction between NKX2-1 mRNA and H19 lncRNA was examined. Putative microRNAs were found at the H19 lncRNA target site with the highest affinity for NKX2-1. RNAseq data was analyzed to determine the tissue specificity of gene expression. Samples were taken from 18 goiter and 18 normal tissues during thyroidectomy. The expression of NKX2-1 was determined by RT-qPCR using specific primers.
Results
The interaction between NKX2-1 and H19 was characterized by six local base-pairing connections, with a maximum energy of −20.56 kcal/moL. Specifically, the sequence that displayed the highest affinity for binding with H19 overlapped with the binding site of has-miR-1827 to NKX2-1. It was found that NKX2-1 is exclusively co-expressed with H19 in normal thyroid tissue. As compared to adjacent normal tissues, nodular goiter tissues have a significant overexpression of NKX2-1 (relative expression = 1.195, p = 0.038).
Conclusion
NKX2-1 has been identified as the putative target of H19 lncRNA, which is overexpressed in nodular goiter tissues significantly.
{"title":"NKX2-1 gene is targeted by H19 lncRNA and is found to be overexpressed in benign nodular goiter tissues","authors":"Seyed-Morteza Javadirad","doi":"10.1016/j.bjorl.2024.101409","DOIUrl":"https://doi.org/10.1016/j.bjorl.2024.101409","url":null,"abstract":"<div><h3>Objective</h3><p>Nodular goiter may increase the risk of thyroid cancer, but the genetic factors contributing to nodular goiter are not well understood. There is an overexpression of H19 lncRNA in goiter tissue and its target remains unknown. In this study, we attempted to identify a new target for H19 in the context of goiter development.</p></div><div><h3>Methods</h3><p>Using interaction energy calculations, the interaction between NKX2-1 mRNA and H19 lncRNA was examined. Putative microRNAs were found at the H19 lncRNA target site with the highest affinity for NKX2-1. RNAseq data was analyzed to determine the tissue specificity of gene expression. Samples were taken from 18 goiter and 18 normal tissues during thyroidectomy. The expression of NKX2-1 was determined by RT-qPCR using specific primers.</p></div><div><h3>Results</h3><p>The interaction between NKX2-1 and H19 was characterized by six local base-pairing connections, with a maximum energy of −20.56 kcal/moL. Specifically, the sequence that displayed the highest affinity for binding with H19 overlapped with the binding site of has-miR-1827 to NKX2-1. It was found that NKX2-1 is exclusively co-expressed with H19 in normal thyroid tissue. As compared to adjacent normal tissues, nodular goiter tissues have a significant overexpression of NKX2-1 (relative expression = 1.195, <em>p</em> = 0.038).</p></div><div><h3>Conclusion</h3><p>NKX2-1 has been identified as the putative target of H19 lncRNA, which is overexpressed in nodular goiter tissues significantly.</p></div><div><h3>Level of Evidence</h3><p>4.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000247/pdfft?md5=3a426522b542632b12251e1fe25828a6&pid=1-s2.0-S1808869424000247-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.1016/j.bjorl.2024.101405
Jia Liu , Shui-Hong Zhou
Objective
Kawasaki Disease (KD) may mimic Parapharyngeal (PPI) and Retropharyngeal Infections (RPI), leading to misdiagnosis as Deep Neck Infections (DNIs). The treatment plans for the two diseases are different, and delayed treatment can lead to serious complications. Therefore, prompt diagnosis and management are necessary. This study was performed to evaluate the clinical features of KD mimicking DNIs and explore the treatment options.
Methods
Children with cellulitis or abscess in parapharyngeal or retropharyngeal space in neck CT were included in this study. The medical records of enrolled children were retrospectively reviewed.
Results
In total, 56 children were diagnosed with PPI or/and RPI. Twenty-two (39.3%) participants were eventually diagnosed with KD, and 34 (60.7%) were diagnosed with DNIs. Compared with the DNIs group, the KD group had a higher body temperature (p = 0.007), and higher levels of AST (p = 0.040), ALT (p = 0.027), and ESR (p = 0.030). Deep cervical cellulitis (p = 0.005) were more common in the KD group. However, deep neck abscess often occurred in the DNIs group (p = 0.002), with parapharyngeal abscess being the most common type of abscess (p = 0.004). The KD mimicking DNIs cases did not respond to antibiotic treatment, but symptoms significantly improved after the use of Immunoglobulin (IVIG) and aspirin.
Conclusion
Children with KD may exhibit retropharyngeal or parapharyngeal inflammation in the early stages. KD should be considered a differential diagnosis for children with DNIs, high fever, and no response to antibiotic therapy. Surgery in KD mimicking deep neck abscess requires caution.
{"title":"Parapharyngeal and retropharyngeal infections in children: Kawasaki disease needs vigilance","authors":"Jia Liu , Shui-Hong Zhou","doi":"10.1016/j.bjorl.2024.101405","DOIUrl":"10.1016/j.bjorl.2024.101405","url":null,"abstract":"<div><h3>Objective</h3><p>Kawasaki Disease (KD) may mimic Parapharyngeal (PPI) and Retropharyngeal Infections (RPI), leading to misdiagnosis as Deep Neck Infections (DNIs). The treatment plans for the two diseases are different, and delayed treatment can lead to serious complications. Therefore, prompt diagnosis and management are necessary. This study was performed to evaluate the clinical features of KD mimicking DNIs and explore the treatment options.</p></div><div><h3>Methods</h3><p>Children with cellulitis or abscess in parapharyngeal or retropharyngeal space in neck CT were included in this study. The medical records of enrolled children were retrospectively reviewed.</p></div><div><h3>Results</h3><p>In total, 56 children were diagnosed with PPI or/and RPI. Twenty-two (39.3%) participants were eventually diagnosed with KD, and 34 (60.7%) were diagnosed with DNIs. Compared with the DNIs group, the KD group had a higher body temperature (<em>p</em> <!-->=<!--> <!-->0.007), and higher levels of AST (<em>p</em> <!-->=<!--> <!-->0.040), ALT (<em>p</em> <!-->=<!--> <!-->0.027), and ESR (<em>p</em> <!-->=<!--> <!-->0.030). Deep cervical cellulitis (<em>p</em> <!-->=<!--> <!-->0.005) were more common in the KD group. However, deep neck abscess often occurred in the DNIs group (<em>p</em> <!-->=<!--> <!-->0.002), with parapharyngeal abscess being the most common type of abscess (<em>p</em> <!-->=<!--> <!-->0.004). The KD mimicking DNIs cases did not respond to antibiotic treatment, but symptoms significantly improved after the use of Immunoglobulin (IVIG) and aspirin.</p></div><div><h3>Conclusion</h3><p>Children with KD may exhibit retropharyngeal or parapharyngeal inflammation in the early stages. KD should be considered a differential diagnosis for children with DNIs, high fever, and no response to antibiotic therapy. Surgery in KD mimicking deep neck abscess requires caution.</p></div><div><h3>Level of Evidence</h3><p>I.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S180886942400020X/pdfft?md5=73de01322858d678c1792dc2574ecc4b&pid=1-s2.0-S180886942400020X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139949681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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