Pub Date : 2024-10-15DOI: 10.1016/j.reval.2024.104142
M. Bouron , C. Dufrois , I. Himeur , J. Personnic , S. Saf , G. Benoist
Celery is an allergen not to be overlooked, as it is used in the food industry as well as in cosmetics. The prevalence of celery allergy remains low in the pediatric population, but is higher in adults, with a high risk of anaphylaxis. Celery allergens differ from one another in their characteristics: content within the different types of celery, sensitivity to heat, link with certain phenotypes (pollen-food syndrome). For diagnosis, native prick-tests are more sensitive than commercial extracts. Source-specific IgE may fail in a third of cases, and recombinant allergens are sometimes useful. Oral provocation testing is essential in cases of diagnostic doubt. The natural history of this allergy is not well described, and the cure rate is difficult to estimate. Avoidance of celery is the mainstay of treatment.
{"title":"Allergie au céleri","authors":"M. Bouron , C. Dufrois , I. Himeur , J. Personnic , S. Saf , G. Benoist","doi":"10.1016/j.reval.2024.104142","DOIUrl":"10.1016/j.reval.2024.104142","url":null,"abstract":"<div><div>Celery is an allergen not to be overlooked, as it is used in the food industry as well as in cosmetics. The prevalence of celery allergy remains low in the pediatric population, but is higher in adults, with a high risk of anaphylaxis. Celery allergens differ from one another in their characteristics: content within the different types of celery, sensitivity to heat, link with certain phenotypes (pollen-food syndrome). For diagnosis, native prick-tests are more sensitive than commercial extracts. Source-specific IgE may fail in a third of cases, and recombinant allergens are sometimes useful. Oral provocation testing is essential in cases of diagnostic doubt. The natural history of this allergy is not well described, and the cure rate is difficult to estimate. Avoidance of celery is the mainstay of treatment.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 2","pages":"Article 104142"},"PeriodicalIF":0.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-15DOI: 10.1016/j.reval.2024.104145
L. Colin , M. Tauber , A.L. Souillet , L. Coutier , P. Reix , P. Biermé , A. Nosbaum , C. Braun
Context
Complexity of atopic trajectories, increased severity of atopic diseases and emergence of new therapies require expertise in atopy. Here, we would like to give feedbacks from a multidisciplinary consultation called “Severe atopy in children”, set up in the Hospices Civils de Lyon.
Methods
Retrospective reviews of patients’ charts were conducted.
Results
The consultation “Severe atopy in children” was conducted by pulmonologists, dermatologists, and immunologists with a training background of pediatricians and allergists. During this one-hour consultation, atopic conditions of various organs were evaluated and taken into consideration for specific, and if possible, global management, including the prescription of systemic treatments. In total, 48 children have accessed this consultation, all of whom are suffering from atopic dermatitis, with 68% having a severe form. Atopy comorbidity was found in 83% of patients, including 56% having IgE-mediated food allergy, 58% having asthma, and 60% having allergic rhinoconjunctivitis. A systemic treatment was prescribed to 62% of patients during the first consultation. Inhaled treatments were also optimized for asthmatics and the majority of food-allergic patients receiving oral immunotherapy in the follow-up.
Conclusion
The multidisciplinary consultation “Severe Atopy in Children” offers comprehensive care to children with atopic disorders and has the potential to become a cornerstone in the management of childhood atopy.
{"title":"Retours d’expérience d’une consultation pluridisciplinaire « Atopie sévère de l’enfant » aux Hospices Civils de Lyon","authors":"L. Colin , M. Tauber , A.L. Souillet , L. Coutier , P. Reix , P. Biermé , A. Nosbaum , C. Braun","doi":"10.1016/j.reval.2024.104145","DOIUrl":"10.1016/j.reval.2024.104145","url":null,"abstract":"<div><h3>Context</h3><div>Complexity of atopic trajectories, increased severity of atopic diseases and emergence of new therapies require expertise in atopy. Here, we would like to give feedbacks from a multidisciplinary consultation called “Severe atopy in children”, set up in the Hospices Civils de Lyon.</div></div><div><h3>Methods</h3><div>Retrospective reviews of patients’ charts were conducted.</div></div><div><h3>Results</h3><div>The consultation “Severe atopy in children” was conducted by pulmonologists, dermatologists, and immunologists with a training background of pediatricians and allergists. During this one-hour consultation, atopic conditions of various organs were evaluated and taken into consideration for specific, and if possible, global management, including the prescription of systemic treatments. In total, 48 children have accessed this consultation, all of whom are suffering from atopic dermatitis, with 68% having a severe form. Atopy comorbidity was found in 83% of patients, including 56% having IgE-mediated food allergy, 58% having asthma, and 60% having allergic rhinoconjunctivitis. A systemic treatment was prescribed to 62% of patients during the first consultation. Inhaled treatments were also optimized for asthmatics and the majority of food-allergic patients receiving oral immunotherapy in the follow-up.</div></div><div><h3>Conclusion</h3><div>The multidisciplinary consultation “Severe Atopy in Children” offers comprehensive care to children with atopic disorders and has the potential to become a cornerstone in the management of childhood atopy.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104145"},"PeriodicalIF":0.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142437834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-10DOI: 10.1016/j.reval.2024.104170
H. Chabane , P. Poncet , S. Mécheri
Né le 8 décembre 1935 à Noisy-le-Grand, Bernard David, professeur à l’Institut Pasteur, directeur de l’unité d’immuno-allergie de 1977 à 2000 est décédé le 15 juin 2024 à l’âge de 88 ans. Ses amis chercheurs, allergologues et biologistes adressent leurs sincères condoléances à sa famille et ses proches.
{"title":"Adieux à un maître et un ami, le Pr Bernard David (1935–2024)","authors":"H. Chabane , P. Poncet , S. Mécheri","doi":"10.1016/j.reval.2024.104170","DOIUrl":"10.1016/j.reval.2024.104170","url":null,"abstract":"<div><div>Né le 8 décembre 1935 à Noisy-le-Grand, Bernard David, professeur à l’Institut Pasteur, directeur de l’unité d’immuno-allergie de 1977 à 2000 est décédé le 15 juin 2024 à l’âge de 88 ans. Ses amis chercheurs, allergologues et biologistes adressent leurs sincères condoléances à sa famille et ses proches.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104170"},"PeriodicalIF":0.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-09DOI: 10.1016/j.reval.2024.104146
I. Hayoun, F. El Haskouri, H. Bouziane
The study aims to assess the diversity, dominance, interannual and seasonal variation of airborne fungal spores of Tétouan during 2015–2017, as well as the impact of meteorological parameters on their daily concentrations by using Spearman correlation and multivariate canonical correspondence analysis (CCA) to elucidate these relationships. Additionally, the study presents a fungal spore calendar, which serves to define the timing, duration, and intensity of spore emission. Aerobiological analysis revealed a high diversity of fungal spores, with over 63 types identified. The annual spore integral (ASIn) varied between 502,910 in 2016 and 666,705 spore * d/m3 in 2015. Predominantly, spore types belonged to the groups of Ascomycota (82%, including fungi imperfecti), Basidiomycota (15%), and Zygomycota (3%). The most abundant species included Cladosporium, Ustilago, Alternaria, Leptospharia, Oidium agent spores, Aspergillaceae, Stemphylium, Torula, Arthrinium, and Pleospora, generally between spring and fall. Temperature emerged as a crucial factor in the dispersal of Alternaria, Cladosporium, Stemphylium, Torula, and Ustilago spores, whereas Ascospores, Leptosphaeria, Pleospora, and basidiospores exhibited positive and significant correlations with humidity and precipitation. The fungal spore calendar illustrated the diversity of spores (16 types), their presence throughout the year, and extended spore emission periods. However, the presence of fungal spores varied annually based on local weather factors and could potentially cause health risks to allergic individuals. Overall, the study sheds light on the complex interactions between fungal spores and meteorological parameters, providing valuable insights into airborne fungal ecology and its implications for human health.
{"title":"Airborne fungal spores in Tétouan (NW of Morocco), sporal calendar and meteorogical parameters","authors":"I. Hayoun, F. El Haskouri, H. Bouziane","doi":"10.1016/j.reval.2024.104146","DOIUrl":"10.1016/j.reval.2024.104146","url":null,"abstract":"<div><div>The study aims to assess the diversity, dominance, interannual and seasonal variation of airborne fungal spores of Tétouan during 2015–2017, as well as the impact of meteorological parameters on their daily concentrations by using Spearman correlation and multivariate canonical correspondence analysis (CCA) to elucidate these relationships. Additionally, the study presents a fungal spore calendar, which serves to define the timing, duration, and intensity of spore emission. Aerobiological analysis revealed a high diversity of fungal spores, with over 63 types identified. The annual spore integral (ASIn) varied between 502,910 in 2016 and 666,705 spore * d/m<sup>3</sup> in 2015. Predominantly, spore types belonged to the groups of Ascomycota (82%, including fungi imperfecti), Basidiomycota (15%), and Zygomycota (3%). The most abundant species included <em>Cladosporium</em>, <em>Ustilago</em>, <em>Alternaria</em>, <em>Leptospharia</em>, Oidium agent spores, Aspergillaceae, <em>Stemphylium</em>, <em>Torula</em>, <em>Arthrinium</em>, and <em>Pleospora</em>, generally between spring and fall. Temperature emerged as a crucial factor in the dispersal of <em>Alternaria</em>, <em>Cladosporium</em>, <em>Stemphylium</em>, <em>Torula</em>, and <em>Ustilago</em> spores, whereas Ascospores, <em>Leptosphaeria</em>, <em>Pleospora</em>, and basidiospores exhibited positive and significant correlations with humidity and precipitation. The fungal spore calendar illustrated the diversity of spores (16 types), their presence throughout the year, and extended spore emission periods. However, the presence of fungal spores varied annually based on local weather factors and could potentially cause health risks to allergic individuals. Overall, the study sheds light on the complex interactions between fungal spores and meteorological parameters, providing valuable insights into airborne fungal ecology and its implications for human health.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104146"},"PeriodicalIF":0.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-09DOI: 10.1016/j.reval.2024.104144
R. Abdellaziz , E. Sadi , M. Ouali , N. Mazouz
The problems of human–bird cohabitation are not a recent phenomenon even if today their importance has taken on an indisputable extent. Their droppings contain significant concentrations of microorganisms and can cause allergic diseases, such as hypersensitivity pneumonitis (HSP), formerly called extrinsic allergic alveolitis, but also rhinitis, asthma or conjunctivitis. We report a rare case of allergy to bird droppings in a patient who raises chickens and canaries, having consulted for rhinoconjunctivitis whose allergological assessment found sensitization of these droppings with positive skin and specific IgE tests. Its management consisted of avoiding the risk with medical treatment. It is a rare pathology that must be considered in the event of exposure to birds.
{"title":"Allergies aux fientes d’oiseaux","authors":"R. Abdellaziz , E. Sadi , M. Ouali , N. Mazouz","doi":"10.1016/j.reval.2024.104144","DOIUrl":"10.1016/j.reval.2024.104144","url":null,"abstract":"<div><div>The problems of human–bird cohabitation are not a recent phenomenon even if today their importance has taken on an indisputable extent. Their droppings contain significant concentrations of microorganisms and can cause allergic diseases, such as hypersensitivity pneumonitis (HSP), formerly called extrinsic allergic alveolitis, but also rhinitis, asthma or conjunctivitis. We report a rare case of allergy to bird droppings in a patient who raises chickens and canaries, having consulted for rhinoconjunctivitis whose allergological assessment found sensitization of these droppings with positive skin and specific IgE tests. Its management consisted of avoiding the risk with medical treatment. It is a rare pathology that must be considered in the event of exposure to birds.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104144"},"PeriodicalIF":0.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-09DOI: 10.1016/j.reval.2024.104143
L. Benjelloun , P. Bonniaud , A. Grandvuillemin , E. Collet , C. Leleu
Dupilumab is a fully human anti-interleukin-4-and 13 monoclonal antibody commonly used in the treatment of severe atopic dermatitis and severe asthma. We report a case of maculopapular exanthema that occurred after the first injection of dupilumab in a young patient treated for severe asthma.
{"title":"Dupilumab induced maculopapular exanthema: A case report","authors":"L. Benjelloun , P. Bonniaud , A. Grandvuillemin , E. Collet , C. Leleu","doi":"10.1016/j.reval.2024.104143","DOIUrl":"10.1016/j.reval.2024.104143","url":null,"abstract":"<div><div>Dupilumab is a fully human anti-interleukin-4-and 13 monoclonal antibody commonly used in the treatment of severe atopic dermatitis and severe asthma. We report a case of maculopapular exanthema that occurred after the first injection of dupilumab in a young patient treated for severe asthma.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104143"},"PeriodicalIF":0.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-09DOI: 10.1016/j.reval.2024.104160
N. Liu , J. Wang , M. Zhang
Objectives
Allergic rhinitis (AR) is a pervasive condition, affecting a significant global population, often with lifelong implications. The objective of this study is to screen for inflammatory-related differential proteins in the urine of AR patients, aiming to analyze the correlation between these identified proteins and the severity of allergic rhinitis.
Design and methods
To diagnose AR, we utilized the sIgE test to measure the allergenic responses. Based on the total IgE levels, patients were segregated into two categories: AR1 (IgE > 125 IU/mL) and AR2 (IgE ≤ 125 IU/mL). The differential proteins related to inflammation in the urine of patients were screened using TMT labeling combined with LC–MS/MS. Subsequently, these proteins were validated through PRM-based proteomics quantification.
Results
We found significant increases in FCGR3A, A1AT, KRT18, and IL18 in the AR group (P < 0.001). PRM-based quantification results highlighted considerable differences in the concentrations of these four proteins across varying degrees of allergic rhinitis severity. A biomarker panel comprising FCGR3A, A1AT, KRT18, and IL18 was identified, with an area under the curve (AUC) value of 0.993 for the detection of AR.
Conclusions
This study provides the first comprehensive report of combined TMT labeling LC–MS/MS quantitative proteomics and PRM analysis for discovering urinary biomarkers related to inflammatory responses in AR. These findings may be instrumental in evaluating the severity of allergic rhinitis and further our understanding of the molecular mechanisms underlying AR.
目的过敏性鼻炎（AR）是一种普遍存在的疾病，影响着全球大量人口，往往会造成终生影响。本研究的目的是筛查 AR 患者尿液中与炎症相关的差异蛋白，旨在分析这些被鉴定出的蛋白与过敏性鼻炎严重程度之间的相关性。设计与方法为了诊断 AR，我们利用 sIgE 试验来测量过敏原反应。根据总 IgE 水平，将患者分为两类：AR1（IgE > 125 IU/mL）和 AR2（IgE ≤ 125 IU/mL）。利用 TMT 标记和 LC-MS/MS 技术筛选出患者尿液中与炎症有关的差异蛋白。结果我们发现在 AR 组中，FCGR3A、A1AT、KRT18 和 IL18 的含量显著增加（P < 0.001）。基于 PRM 的定量结果显示，在不同程度的过敏性鼻炎中，这四种蛋白质的浓度存在很大差异。该研究首次全面报告了结合 TMT 标记 LC-MS/MS 定量蛋白质组学和 PRM 分析发现与 AR 炎症反应相关的尿液生物标记物的情况。这些发现可能有助于评估过敏性鼻炎的严重程度，并进一步加深我们对 AR 的分子机制的了解。
{"title":"Discovery of inflammatory response-related proteins as candidate urinary biomarkers of allergic rhinitis","authors":"N. Liu , J. Wang , M. Zhang","doi":"10.1016/j.reval.2024.104160","DOIUrl":"10.1016/j.reval.2024.104160","url":null,"abstract":"<div><h3>Objectives</h3><div>Allergic rhinitis (AR) is a pervasive condition, affecting a significant global population, often with lifelong implications. The objective of this study is to screen for inflammatory-related differential proteins in the urine of AR patients, aiming to analyze the correlation between these identified proteins and the severity of allergic rhinitis.</div></div><div><h3>Design and methods</h3><div>To diagnose AR, we utilized the sIgE test to measure the allergenic responses. Based on the total IgE levels, patients were segregated into two categories: AR1 (IgE<!--> <!-->><!--> <!-->125<!--> <!-->IU/mL) and AR2 (IgE<!--> <!-->≤<!--> <!-->125<!--> <!-->IU/mL). The differential proteins related to inflammation in the urine of patients were screened using TMT labeling combined with LC–MS/MS. Subsequently, these proteins were validated through PRM-based proteomics quantification.</div></div><div><h3>Results</h3><div>We found significant increases in FCGR3A, A1AT, KRT18, and IL18 in the AR group (<em>P</em> <!--><<!--> <!-->0.001). PRM-based quantification results highlighted considerable differences in the concentrations of these four proteins across varying degrees of allergic rhinitis severity. A biomarker panel comprising FCGR3A, A1AT, KRT18, and IL18 was identified, with an area under the curve (AUC) value of 0.993 for the detection of AR.</div></div><div><h3>Conclusions</h3><div>This study provides the first comprehensive report of combined TMT labeling LC–MS/MS quantitative proteomics and PRM analysis for discovering urinary biomarkers related to inflammatory responses in AR. These findings may be instrumental in evaluating the severity of allergic rhinitis and further our understanding of the molecular mechanisms underlying AR.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104160"},"PeriodicalIF":0.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-20DOI: 10.1016/j.reval.2024.104161
G. Sqalli-Houssini , Z. Douhi , M. Soughi , S. Elloudi , H. Baybay , B. Moukafih , M. Omari , K. El Rhazi , F.Z. Mernissi
Study objective
The DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is a severe and potentially fatal toxidermia due to various visceral involvements. Identifying factors predisposing to serious complications is essential for clinical and therapeutic management. This study aims to analyze the cutaneous presentation of DRESS and its role as a prognostic factor.
Patients and methods
This is a retrospective, descriptive, and analytical study conducted over nine years at the dermatology department in Fes, including all hospitalized DRESS cases.
Results
The maculopapular rash was the most frequent phenotype (49.3%), followed by erythroderma, morbilliform exanthem, and polymorphous erythema-like rash. In all, 52.8% of patients had renal involvement and 45.8% had hepatic involvement, while 81.9% exhibited hypereosinophilia. The maculopapular rash and erythroderma were more associated with internal organ involvement, although no significant statistical correlation could be demonstrated. Allopurinol was the most implicated drug in 51.4% of the cases. No correlation was found between the type of medication and the cutaneous presentation. In all, 8.3% of the patients died, primarily those with erythroderma (15.8%).
Conclusion
Our study demonstrated that maculopapular rash and erythroderma are the most common presentations and are most associated with internal organ complications, with a more unfavorable prognosis for erythrodermic cases.
{"title":"Drug reaction with eosinophilia and systemic symptoms: Analysis of cutaneous phenotype as a prognosis factor","authors":"G. Sqalli-Houssini , Z. Douhi , M. Soughi , S. Elloudi , H. Baybay , B. Moukafih , M. Omari , K. El Rhazi , F.Z. Mernissi","doi":"10.1016/j.reval.2024.104161","DOIUrl":"10.1016/j.reval.2024.104161","url":null,"abstract":"<div><h3>Study objective</h3><p>The DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is a severe and potentially fatal toxidermia due to various visceral involvements. Identifying factors predisposing to serious complications is essential for clinical and therapeutic management. This study aims to analyze the cutaneous presentation of DRESS and its role as a prognostic factor.</p></div><div><h3>Patients and methods</h3><p>This is a retrospective, descriptive, and analytical study conducted over nine years at the dermatology department in Fes, including all hospitalized DRESS cases.</p></div><div><h3>Results</h3><p>The maculopapular rash was the most frequent phenotype (49.3%), followed by erythroderma, morbilliform exanthem, and polymorphous erythema-like rash. In all, 52.8% of patients had renal involvement and 45.8% had hepatic involvement, while 81.9% exhibited hypereosinophilia. The maculopapular rash and erythroderma were more associated with internal organ involvement, although no significant statistical correlation could be demonstrated. Allopurinol was the most implicated drug in 51.4% of the cases. No correlation was found between the type of medication and the cutaneous presentation. In all, 8.3% of the patients died, primarily those with erythroderma (15.8%).</p></div><div><h3>Conclusion</h3><p>Our study demonstrated that maculopapular rash and erythroderma are the most common presentations and are most associated with internal organ complications, with a more unfavorable prognosis for erythrodermic cases.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104161"},"PeriodicalIF":0.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-24DOI: 10.1016/j.reval.2024.104138
Amélie Thong Buisson
Context
The nursery welcomes children from a few months to the age of 3 years, age range where there is an increase in cases of anaphylaxis related to food allergies (FA).
Objectives
To draw up an inventory of the training and knowledge of staff with regard to FA. Observe the organization of the Individualized Reception Project (IRP) in the nursery. Take stock of the feelings and possible apprehensions of professionals to work on a daily basis with a child with FA.
Methods
Survey conducted in 2023 with 50 staff working in different childcare facilities.
Results
Seventy-four per cent had initial training on FA, 64% had no training on FA since taking a position in nursery and 66% never handled an adrenaline auto-injector (AAI). Twenty-one per cent of the structures have an internal medicine cabinet to support an inaugural reaction of FA and 14% are equipped with AAI (internal stock not taking into account the AAI of possible IRP). Sixty-eight per cent know that they are allowed to apply the IRP themselves in emergency situations in the nursery, in connection with the ministerial circular of 2021. Sixty-six per cent are comfortable in the daily reception of the child with FA, 38% are comfortable with the handling of the AAI.
Conclusion
Given the increasing frequency of FA in small children, it is necessary for early childhood professionals to be better trained and informed during their studies and in the nursery, especially on the administration of AAI. It is desirable that an in-house pharmacy be equipped with AAI for the management of inaugural FA.
背景该托儿所接收几个月到 3 岁的儿童，在这一年龄段，因食物过敏（FA）而引起的过敏性休克病例有所增加。观察幼儿园个性化接待项目（IRP）的组织情况。方法 2023 年对 50 名在不同托儿所工作的员工进行了调查。结果 74% 的员工接受过有关 FA 的初步培训，64% 的员工自进入托儿所以来未接受过有关 FA 的培训，66% 的员工从未使用过肾上腺素自动注射器 (AAI)。21%的机构设有内部药柜，以支持 FA 的初始反应，14%的机构配备了 AAI（内部库存未考虑可能的 IRP 的 AAI）。68%的人知道，根据 2021 年的部长通告，他们可以在幼儿园的紧急情况下自行使用 IRP。66%的人在日常接待 FA 儿童时感到得心应手，38%的人在处理 AAI 时感到得心应手。结论鉴于幼儿 FA 的发病率越来越高，有必要对幼儿专业人员进行更好的培训，使他们在学习期间和在托儿所中了解更多信息，特别是 AAI 的管理。最好能在内部药房配备 AAI，以管理就诊的 FA。
{"title":"Enfant présentant une allergie alimentaire en crèche : quelle est la place du Projet d’Accueil Individualisé ? Quels ressentis pour le personnel ?","authors":"Amélie Thong Buisson","doi":"10.1016/j.reval.2024.104138","DOIUrl":"10.1016/j.reval.2024.104138","url":null,"abstract":"<div><h3>Context</h3><p>The nursery welcomes children from a few months to the age of 3 years, age range where there is an increase in cases of anaphylaxis related to food allergies (FA).</p></div><div><h3>Objectives</h3><p>To draw up an inventory of the training and knowledge of staff with regard to FA. Observe the organization of the Individualized Reception Project (IRP) in the nursery. Take stock of the feelings and possible apprehensions of professionals to work on a daily basis with a child with FA.</p></div><div><h3>Methods</h3><p>Survey conducted in 2023 with 50 staff working in different childcare facilities.</p></div><div><h3>Results</h3><p>Seventy-four per cent had initial training on FA, 64% had no training on FA since taking a position in nursery and 66% never handled an adrenaline auto-injector (AAI). Twenty-one per cent of the structures have an internal medicine cabinet to support an inaugural reaction of FA and 14% are equipped with AAI (internal stock not taking into account the AAI of possible IRP). Sixty-eight per cent know that they are allowed to apply the IRP themselves in emergency situations in the nursery, in connection with the ministerial circular of 2021. Sixty-six per cent are comfortable in the daily reception of the child with FA, 38% are comfortable with the handling of the AAI.</p></div><div><h3>Conclusion</h3><p>Given the increasing frequency of FA in small children, it is necessary for early childhood professionals to be better trained and informed during their studies and in the nursery, especially on the administration of AAI. It is desirable that an in-house pharmacy be equipped with AAI for the management of inaugural FA.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104138"},"PeriodicalIF":0.3,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-23DOI: 10.1016/j.reval.2024.104141
S. Diadie, M. Tajaoui, P.M. Mbengue, B.A. Diatta, M. Ndiaye, S.O. Niang
Introduction
The aims of this study was to evaluate the impact of therapeutic education on the knowledge and skills of patients with atopic dermatitis at the Aristide Le Dantec University Hospital.
Patients and method
This prospective educational intervention study included 22 participants with AD. Knowledge was assessed before and after the therapeutic education sessions. The educational tools of the Pierre-Fabre Eczema Foundation translated into power points served as educational support to which creations of educational tools and iconographies on black skin were added. The comparison of means was made using the Student test.
Results
The educational diagnosis highlighted a lack of knowledge of: the disease, its aggravating factors, its treatments as well as frequent corticophobia. The therapeutic education allowed the acquisition of theoretical knowledge and practical skills in addition to empowering the participants. In addition, it reduced corticophobia although fear of topical corticosteroids persisted.
Conclusion
Patient therapeutic education through educational tools contextualized for our patients made it possible to improve knowledge and skills during atopic dermatitis.
{"title":"L’école de la dermatite atopique en dermatologie à Dakar : étude d’impact sur les connaissances à propos de 22 participants","authors":"S. Diadie, M. Tajaoui, P.M. Mbengue, B.A. Diatta, M. Ndiaye, S.O. Niang","doi":"10.1016/j.reval.2024.104141","DOIUrl":"10.1016/j.reval.2024.104141","url":null,"abstract":"<div><h3>Introduction</h3><p>The aims of this study was to evaluate the impact of therapeutic education on the knowledge and skills of patients with atopic dermatitis at the Aristide Le Dantec University Hospital.</p></div><div><h3>Patients and method</h3><p>This prospective educational intervention study included 22 participants with AD. Knowledge was assessed before and after the therapeutic education sessions. The educational tools of the Pierre-Fabre Eczema Foundation translated into power points served as educational support to which creations of educational tools and iconographies on black skin were added. The comparison of means was made using the Student test.</p></div><div><h3>Results</h3><p>The educational diagnosis highlighted a lack of knowledge of: the disease, its aggravating factors, its treatments as well as frequent corticophobia. The therapeutic education allowed the acquisition of theoretical knowledge and practical skills in addition to empowering the participants. In addition, it reduced corticophobia although fear of topical corticosteroids persisted.</p></div><div><h3>Conclusion</h3><p>Patient therapeutic education through educational tools contextualized for our patients made it possible to improve knowledge and skills during atopic dermatitis.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104141"},"PeriodicalIF":0.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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