Pub Date : 2025-11-01Epub Date: 2025-08-11DOI: 10.1016/j.reval.2025.104599
M. Oulad Kouider , A. Fissah , H. Madi , M.S. Aissani , K. Bouchbouch , K. Ouennoughi , A. Bachir Cherif , F. Zedam , L. Zemmour , S. Benzaoui , Z. Boukara , M. Kibboua , S. Alihalassa
Introduction
Although patients with severe asthma constitute only around 5% to 10% of asthmatic patients, they account for almost half of the costs related to this condition. This situation is related to the disease itself and its comorbidities.
Methods
This is a prospective observational study in the academic hospital of Blida in Algeria. Data were collected from May 2019 to November 2021. Only patients who met the criteria of severe asthma according to the definition GINA 2018. The included patients received a multidisciplinary approach along with personalized education.
Results
One hundred and fifty patients were included, and 65.3% of them were women. Among the patients, 93.3% had comorbidities, with chronic allergic rhinitis being the most common allergic comorbidity. Meanwhile, gastroesophageal reflux was the most prevalent non-allergic comorbidity (48.7%). After multidisciplinary care, only 27.3% of the participants continued to have severe asthma.
Conclusion
Patients with severe asthma require personalized education and the collaboration of different specialists.
{"title":"Impact de la prise en charge multidisciplinaire sur le contrôle et l’évolution de l’asthme difficile","authors":"M. Oulad Kouider , A. Fissah , H. Madi , M.S. Aissani , K. Bouchbouch , K. Ouennoughi , A. Bachir Cherif , F. Zedam , L. Zemmour , S. Benzaoui , Z. Boukara , M. Kibboua , S. Alihalassa","doi":"10.1016/j.reval.2025.104599","DOIUrl":"10.1016/j.reval.2025.104599","url":null,"abstract":"<div><h3>Introduction</h3><div>Although patients with severe asthma constitute only around 5% to 10% of asthmatic patients, they account for almost half of the costs related to this condition. This situation is related to the disease itself and its comorbidities.</div></div><div><h3>Methods</h3><div>This is a prospective observational study in the academic hospital of Blida in Algeria. Data were collected from May 2019 to November 2021. Only patients who met the criteria of severe asthma according to the definition GINA 2018. The included patients received a multidisciplinary approach along with personalized education.</div></div><div><h3>Results</h3><div>One hundred and fifty patients were included, and 65.3% of them were women. Among the patients, 93.3% had comorbidities, with chronic allergic rhinitis being the most common allergic comorbidity. Meanwhile, gastroesophageal reflux was the most prevalent non-allergic comorbidity (48.7%). After multidisciplinary care, only 27.3% of the participants continued to have severe asthma.</div></div><div><h3>Conclusion</h3><div>Patients with severe asthma require personalized education and the collaboration of different specialists.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 6","pages":"Article 104599"},"PeriodicalIF":0.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-09-25DOI: 10.1016/j.reval.2025.104603
B.C. Duran, E. Bahadir, S. Demirsöz, C. Aytekin, S. Özmen
Serum sickness-like reaction (SSLR) is a rare, non-IgE-mediated hypersensitivity reaction typically occurring in early childhood, characterized by nonspecific symptoms such as rash, fever, and joint involvement. Although symptoms generally emerge 5–21 days after drug exposure, earlier onset may occur in sensitized individuals upon repeated exposure to the same agent. We report the case of a 5-year old boy who developed fever, erythema, and extremity pain within 12 hours of a drug provocation test (DPT) with amoxicillin-clavulanic acid (ACA). A second DPT performed one month later triggered similar symptoms within 3 hours, confirming the diagnosis of SSLR. Laboratory findings supported systemic inflammation, and the symptoms resolved with corticosteroid treatment. This case highlights the variability in SSLR symptom onset and emphasizes the potential utility of DPT in selected cases to confirm the diagnosis and avoid unnecessary drug elimination. It also draws attention to the need for careful patient selection and standardized protocols when performing DPT in suspected SSLR.
{"title":"Early-onset serum sickness-like reaction: Role of drug provocation tests in diagnosis","authors":"B.C. Duran, E. Bahadir, S. Demirsöz, C. Aytekin, S. Özmen","doi":"10.1016/j.reval.2025.104603","DOIUrl":"10.1016/j.reval.2025.104603","url":null,"abstract":"<div><div>Serum sickness-like reaction (SSLR) is a rare, non-IgE-mediated hypersensitivity reaction typically occurring in early childhood, characterized by nonspecific symptoms such as rash, fever, and joint involvement. Although symptoms generally emerge 5–21 days after drug exposure, earlier onset may occur in sensitized individuals upon repeated exposure to the same agent. We report the case of a 5-year old boy who developed fever, erythema, and extremity pain within 12<!--> <!-->hours of a drug provocation test (DPT) with amoxicillin-clavulanic acid (ACA). A second DPT performed one month later triggered similar symptoms within 3<!--> <!-->hours, confirming the diagnosis of SSLR. Laboratory findings supported systemic inflammation, and the symptoms resolved with corticosteroid treatment. This case highlights the variability in SSLR symptom onset and emphasizes the potential utility of DPT in selected cases to confirm the diagnosis and avoid unnecessary drug elimination. It also draws attention to the need for careful patient selection and standardized protocols when performing DPT in suspected SSLR.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 6","pages":"Article 104603"},"PeriodicalIF":0.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01Epub Date: 2025-11-05DOI: 10.1016/j.reval.2025.104622
Le bureau de la Société française d’allergologie et le comité de rédaction de la Revue française d’allergologie
{"title":"Sébastien Lefèvre (1976–2025)","authors":"Le bureau de la Société française d’allergologie et le comité de rédaction de la Revue française d’allergologie","doi":"10.1016/j.reval.2025.104622","DOIUrl":"10.1016/j.reval.2025.104622","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 6","pages":"Article 104622"},"PeriodicalIF":0.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-11DOI: 10.1016/j.reval.2025.104598
N. Taouri, A. Amazouzi, N. Boutimzine, O. Cherkaoui
Fluorescein retinal angiography is a very well tolerated test; however adverse reactions of various severity have been reported, ranging from simple nausea to anaphylactic shock. Nausea, followed by vomiting are the most common anaphylactic incident after fluorescein injection. Premedication is sometimes indicated for patients at risk. Some authors propose desensitization protocols before carrying out an examination, while others propose as an alternative a retinal angiography with oral fluorescein, and sometimes the use of OCT (optical coherence tomography), or OCT-A (optical coherence tomography angiography). Finally, for more safety, it is important to equip the examination room with the necessary tools to manage this type of reactions. We report a retrospective study of 4 cases of adverse reaction following the injection of fluorescein for retinal angiography.
{"title":"Les effets indésirables suite à l’injection de la fluorescéine pour la réalisation de l’angiographie rétinienne : rapport de 4 cas","authors":"N. Taouri, A. Amazouzi, N. Boutimzine, O. Cherkaoui","doi":"10.1016/j.reval.2025.104598","DOIUrl":"10.1016/j.reval.2025.104598","url":null,"abstract":"<div><div>Fluorescein retinal angiography is a very well tolerated test; however adverse reactions of various severity have been reported, ranging from simple nausea to anaphylactic shock. Nausea, followed by vomiting are the most common anaphylactic incident after fluorescein injection. Premedication is sometimes indicated for patients at risk. Some authors propose desensitization protocols before carrying out an examination, while others propose as an alternative a retinal angiography with oral fluorescein, and sometimes the use of OCT (optical coherence tomography), or OCT-A (optical coherence tomography angiography). Finally, for more safety, it is important to equip the examination room with the necessary tools to manage this type of reactions. We report a retrospective study of 4 cases of adverse reaction following the injection of fluorescein for retinal angiography.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 5","pages":"Article 104598"},"PeriodicalIF":0.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-05-20DOI: 10.1016/j.reval.2025.104568
I. Bouaziz, R. Atheymen, R. Sahnoun, K. Ksouda, H. Affes, S. Hammami, K. Zghal
Objective
The aim of our study was to evaluate the utility of the patch-tests for the diagnosis of the delayed hypersensitivity reactions induced by antiepileptic drugs and to explore cross-reactivity between them.
Patients and methods
We included cases of delayed drug addiction to antiepileptics notified to the Sfax regional pharmacovigilance center during the period from January 2019 to June 2023. We used the French Bégaud method for the study of imputability. Patch testing was performed in all patients according to the recommendations of the European Network of Drug Allergy. The interpretation of the results was made according to the rules of the International Contact Dermatitis Research Group.
Results
We included 17 delayed drug reactions: Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome (n = 10), maculopapular rash (n = 6), Stevens-Johnson syndrome (n = 1). Patch tests were positive in 76.47% of cases: 66.66% for maculopapular rash with cross-reactivity between carbamazepine and phenobarbital (n = 1) and 90% in DRESS syndrome with cross-reactivity between 2 or more antiepileptics (n = 5). For the patient with Stevens-Johnson syndrome, the tests were interpreted as irritating.
Conclusion
Patch tests are safe and useful to confirm the imputability of antiepileptic drugs in the genesis of delayed drug hypersensibility reaction and to detect possible cross-reactivity.
{"title":"Intérêt des patch tests dans l’exploration des réactions d’hypersensibilité retardée aux antiépileptiques","authors":"I. Bouaziz, R. Atheymen, R. Sahnoun, K. Ksouda, H. Affes, S. Hammami, K. Zghal","doi":"10.1016/j.reval.2025.104568","DOIUrl":"10.1016/j.reval.2025.104568","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of our study was to evaluate the utility of the patch-tests for the diagnosis of the delayed hypersensitivity reactions induced by antiepileptic drugs and to explore cross-reactivity between them.</div></div><div><h3>Patients and methods</h3><div>We included cases of delayed drug addiction to antiepileptics notified to the Sfax regional pharmacovigilance center during the period from January 2019 to June 2023. We used the French Bégaud method for the study of imputability. Patch testing was performed in all patients according to the recommendations of the European Network of Drug Allergy. The interpretation of the results was made according to the rules of the International Contact Dermatitis Research Group.</div></div><div><h3>Results</h3><div>We included 17 delayed drug reactions: Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome (<em>n</em> <!-->=<!--> <!-->10), maculopapular rash (<em>n</em> <!-->=<!--> <!-->6), Stevens-Johnson syndrome (<em>n</em> <!-->=<!--> <!-->1). Patch tests were positive in 76.47% of cases: 66.66% for maculopapular rash with cross-reactivity between carbamazepine and phenobarbital (<em>n</em> <!-->=<!--> <!-->1) and 90% in DRESS syndrome with cross-reactivity between 2 or more antiepileptics (<em>n</em> <!-->=<!--> <!-->5). For the patient with Stevens-Johnson syndrome, the tests were interpreted as irritating.</div></div><div><h3>Conclusion</h3><div>Patch tests are safe and useful to confirm the imputability of antiepileptic drugs in the genesis of delayed drug hypersensibility reaction and to detect possible cross-reactivity.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 5","pages":"Article 104568"},"PeriodicalIF":0.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-07-11DOI: 10.1016/j.reval.2025.104585
E. Seigle-Ferrand , M. Merveilleau , P. Bierme , C. Braun
We report the case of a young boy who was referred to us for suspected anaphylaxis to a local anesthetic during a dental procedure. Shortly after the administration of a local anesthesia using adrenaline-laced articaine, he developed a grade 2 anaphylactic reaction, which was treated with an intramuscular injection of adrenaline. Unable to test articaine (which was still mixed with adrenaline), we tested lidocaine as an alternative and then performed a subcutaneous provocation test, which did not elicit any reaction, allowing us to rule out a lidocaine allergy. However, our skin tests, performed after disinfection with chlorhexidine, were positive for latex, which we initially suspected to be responsible for the anaphylactic reaction. But a control prick-test on untreated skin, not disinfected with chlorhexidine, was negative. Upon further questioning, we discovered that the patient had used a mouthwash containing chlorhexidine immediately before the local anesthesia, which had not initially been mentioned either by the dentist or by the family. The chlorhexidine prick-test, as well as specific IgE testing, both returned positive, ultimately confirming sensitization to chlorhexidine. This was therefore an IgE-mediated allergy to chlorhexidine, likely due to mucosal absorption through the breach caused by the gingival local anesthesia. This case serves as a reminder of the need for a systematic and thorough approach in evaluating drug hypersensitivity. Allergy to chlorhexidine should always be considered when investigating perioperative anaphylaxis, even when the product is well tolerated on intact skin or mucous membranes.
{"title":"Réaction anaphylactique énigmatique au cabinet dentaire","authors":"E. Seigle-Ferrand , M. Merveilleau , P. Bierme , C. Braun","doi":"10.1016/j.reval.2025.104585","DOIUrl":"10.1016/j.reval.2025.104585","url":null,"abstract":"<div><div>We report the case of a young boy who was referred to us for suspected anaphylaxis to a local anesthetic during a dental procedure. Shortly after the administration of a local anesthesia using adrenaline-laced articaine, he developed a grade 2 anaphylactic reaction, which was treated with an intramuscular injection of adrenaline. Unable to test articaine (which was still mixed with adrenaline), we tested lidocaine as an alternative and then performed a subcutaneous provocation test, which did not elicit any reaction, allowing us to rule out a lidocaine allergy. However, our skin tests, performed after disinfection with chlorhexidine, were positive for latex, which we initially suspected to be responsible for the anaphylactic reaction. But a control prick-test on untreated skin, not disinfected with chlorhexidine, was negative. Upon further questioning, we discovered that the patient had used a mouthwash containing chlorhexidine immediately before the local anesthesia, which had not initially been mentioned either by the dentist or by the family. The chlorhexidine prick-test, as well as specific IgE testing, both returned positive, ultimately confirming sensitization to chlorhexidine. This was therefore an IgE-mediated allergy to chlorhexidine, likely due to mucosal absorption through the breach caused by the gingival local anesthesia. This case serves as a reminder of the need for a systematic and thorough approach in evaluating drug hypersensitivity. Allergy to chlorhexidine should always be considered when investigating perioperative anaphylaxis, even when the product is well tolerated on intact skin or mucous membranes.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 5","pages":"Article 104585"},"PeriodicalIF":0.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-05-20DOI: 10.1016/j.reval.2025.104581
M. Delin , H. Gadoin , E. Ewig , F. Rocher-Moreau , L. Lipszyc , L. Thomas , A. Creisson , B. Gerard , S. Leroy
Background
Eribulin is a drug that is currently used in metastatic breast cancer as an alternative to taxanes. No allergy has been described yet to this molecule.
Patients and methods
We described two cases in France that present delayed allergy to eribulin after a first cycle. Both of patients received paclitaxel before.
Results
A possible cross-allergy to eribulin with paclitaxel is possible. Our case describes skin testing to eribulin.
Conclusions
Cross-allergy between paclitaxel and eribulin is conceivable. This would be a rare undesirable effect, but one that requires particular attention. The mode of action of these two molecules (inhibition of microtubules) could provide a pathophysiological explanation.
{"title":"Allergie croisée entre paclitaxel et éribuline ?","authors":"M. Delin , H. Gadoin , E. Ewig , F. Rocher-Moreau , L. Lipszyc , L. Thomas , A. Creisson , B. Gerard , S. Leroy","doi":"10.1016/j.reval.2025.104581","DOIUrl":"10.1016/j.reval.2025.104581","url":null,"abstract":"<div><h3>Background</h3><div>Eribulin is a drug that is currently used in metastatic breast cancer as an alternative to taxanes. No allergy has been described yet to this molecule.</div></div><div><h3>Patients and methods</h3><div>We described two cases in France that present delayed allergy to eribulin after a first cycle. Both of patients received paclitaxel before.</div></div><div><h3>Results</h3><div>A possible cross-allergy to eribulin with paclitaxel is possible. Our case describes skin testing to eribulin.</div></div><div><h3>Conclusions</h3><div>Cross-allergy between paclitaxel and eribulin is conceivable. This would be a rare undesirable effect, but one that requires particular attention. The mode of action of these two molecules (inhibition of microtubules) could provide a pathophysiological explanation.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 5","pages":"Article 104581"},"PeriodicalIF":0.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-05-20DOI: 10.1016/j.reval.2025.104583
A. Bocquet , C. Hoarau , L. Carriat , L. Bouillet , S. Guez , I. Boccon-Gibod , N. Marmion
Challenges associated with angioedema differ with patient's age. In children, the most frequent one is bradykinin-related hereditary angioedema (HAE). Diagnosis might be difficult when signs and symptoms are not evocative, such as isolated abdominal crises, in the absence of familial context. Management by multidisciplinary team should be organized rapidly, preferably in an expert center, to allow children living a normal life and experiencing satisfactory development. Adolescence, often characterized by an increase in frequency and severity of crises, must be the period of patient's empowerment in disease management. But it is also a period of instability and turbulences with a possible decreased compliance to treatment. Contraception must be discussed in young female patients due to the relationship between estrogen secretion and HAE attacks. In adults, follow-up and treatment are pursued without any remarkable feature. If HAE appears during adulthood, differential diagnoses should be considered, such as acquired C1 inhibitor deficiency, and associated hemopathies should be detected (monoclonal gammopathy or lymphoproliferative syndrome). Pregnancy requires increased surveillance because of specific risks arising in this situation. Finally, in elderly patients, preexisting HAE is often associated with other comorbidities that can interfere with its evolution, especially because of drug intake. Attacks management may become more difficult and compliance may decrease. Occurrence of HAE after 65 years of age being exceptional, it is important to diagnose iatrogenic angioedema (related in particular to conversion enzyme inhibitors) or thrombolysis of a stroke.
{"title":"L’angiœdème à travers les âges : considérations pratiques","authors":"A. Bocquet , C. Hoarau , L. Carriat , L. Bouillet , S. Guez , I. Boccon-Gibod , N. Marmion","doi":"10.1016/j.reval.2025.104583","DOIUrl":"10.1016/j.reval.2025.104583","url":null,"abstract":"<div><div>Challenges associated with angioedema differ with patient's age. In children, the most frequent one is bradykinin-related hereditary angioedema (HAE). Diagnosis might be difficult when signs and symptoms are not evocative, such as isolated abdominal crises, in the absence of familial context. Management by multidisciplinary team should be organized rapidly, preferably in an expert center, to allow children living a normal life and experiencing satisfactory development. Adolescence, often characterized by an increase in frequency and severity of crises, must be the period of patient's empowerment in disease management. But it is also a period of instability and turbulences with a possible decreased compliance to treatment. Contraception must be discussed in young female patients due to the relationship between estrogen secretion and HAE attacks. In adults, follow-up and treatment are pursued without any remarkable feature. If HAE appears during adulthood, differential diagnoses should be considered, such as acquired C1 inhibitor deficiency, and associated hemopathies should be detected (monoclonal gammopathy or lymphoproliferative syndrome). Pregnancy requires increased surveillance because of specific risks arising in this situation. Finally, in elderly patients, preexisting HAE is often associated with other comorbidities that can interfere with its evolution, especially because of drug intake. Attacks management may become more difficult and compliance may decrease. Occurrence of HAE after 65 years of age being exceptional, it is important to diagnose iatrogenic angioedema (related in particular to conversion enzyme inhibitors) or thrombolysis of a stroke.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 5","pages":"Article 104583"},"PeriodicalIF":0.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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