Revue Francaise d Allergologie最新文献

英文中文

Analyses assistées par cytométrie en flux des basophiles, mastocytes et lymphocytes T dans le diagnostic de l’hypersensibilité immédiate aux médicaments (RHIMs) : une revue 嗜碱性细胞、肥大细胞和T淋巴细胞的细胞流辅助分析：综述

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-12-21 DOI: 10.1016/j.reval.2025.104634

D.G. Ebo , C. Mertens , M. Van Houdt , A. Toscano , M. Beyens , M.M. Hagendorens , D. Yerly , V. Sabato , O. Hausmann , J. Elst

Immediate drug hypersensitivity reactions (IDHRs) pose significant diagnostic challenges, often requiring potentially hazardous drug challenge testing (DCT). Recent studies have indicated that flow cytometry-based cellular tests, including the basophil activation test (BAT), the mast cell activation test (MAT), and the T cell activation test (TAT), offer a promising alternative to reduce DCT reliance. While these tests are still in development, they demonstrate potential to compete with skin tests by providing superior diagnostic performance and improved patient safety by reducing the need for DCT. Moreover, it is encouraging that these flow cytometry-based tests are also suitable for challenging populations, such as children. Despite requiring specialised infrastructure, these tests have the potential to be cost-effective when performed in reference centres and may offer unique mechanistic insights into immediate drug hypersensitivity reactions. However, further research is required to validate their reliability, address pharmaceutical-specific testing considerations, and potentially integrate them into clinical guidelines.

立即药物超敏反应（IDHRs）带来了重大的诊断挑战，通常需要潜在危险的药物激发试验（DCT）。最近的研究表明，基于流式细胞术的细胞检测，包括嗜碱性粒细胞激活试验（BAT）、肥大细胞激活试验（MAT）和T细胞激活试验（TAT），为减少对DCT的依赖提供了一种有希望的替代方法。虽然这些测试仍在开发中，但它们具有与皮肤测试竞争的潜力，因为它们提供了卓越的诊断性能，并通过减少对DCT的需求提高了患者的安全性。此外，令人鼓舞的是，这些基于流式细胞术的检测也适用于具有挑战性的人群，如儿童。尽管需要专门的基础设施，但这些测试在参考中心进行时可能具有成本效益，并可能提供对即时药物超敏反应的独特机制见解。然而，需要进一步的研究来验证它们的可靠性，解决药物特定测试的考虑，并有可能将它们纳入临床指南。

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引用次数: 0

Sensibilisation aux allergènes polliniques au Maroc : revue des données cliniques publiées de 2000 à 2025 摩洛哥对花粉过敏原的认识：2000 - 2025年发表的临床数据综述

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-12-21 DOI: 10.1016/j.reval.2025.104639

O. Bouaissa

Pollens are among the main seasonal allergens that trigger allergic respiratory diseases, which represent a real public health challenge worldwide. In Morocco, several studies have been conducted to identify the most involved pollens and the associated respiratory diseases. The review of clinical studies published from 2000 to 2025 confirms the dominance of olive tree and grasses at the top of pollen allergens in Morocco. Other pollens, such as cypress, Parietaria, Artemisia, mimosa, and date palm, have shown significant allergenic power but only locally. This distribution is mainly influenced by floristic richness, climate, and air pollution. Allergic rhinitis is the most common response to all pollens, often accompanied by asthma, followed by conjunctivitis and, in some cases, urticaria. Another range of pollens tested only in Casablanca or revealed through surveys deserves further study. Moreover, other chronic diseases reported in these same surveys require clinical investigations. This will help optimize the management and care of allergic respiratory diseases, particularly those triggered by pollens.

花粉是引发过敏性呼吸道疾病的主要季节性过敏原之一，这是全球范围内真正的公共卫生挑战。在摩洛哥，已经进行了几项研究，以确定最常见的花粉和相关的呼吸系统疾病。对2000年至2025年发表的临床研究的回顾证实，在摩洛哥，橄榄树和草在花粉过敏原中占主导地位。其他花粉，如柏树、梧桐树、青蒿、含羞草和枣椰树，也显示出显著的致敏能力，但仅限于局部。这种分布主要受植物区系丰富度、气候和空气污染的影响。过敏性鼻炎是对所有花粉最常见的反应，通常伴有哮喘，其次是结膜炎，在某些情况下，荨麻疹。另一种仅在卡萨布兰卡测试或通过调查发现的花粉值得进一步研究。此外，在这些调查中报告的其他慢性疾病需要临床调查。这将有助于优化过敏性呼吸道疾病的管理和护理，特别是那些由花粉引发的疾病。

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引用次数: 0

Un cas rare de DRESS syndrome suite à la prise d’acénocoumarol 服用阿西诺库玛罗后的罕见DRESS病例

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-12-21 DOI: 10.1016/j.reval.2025.104621

A. Lahrougui, M. Aboudourib, L. Bendaoud, S. Amal, O. Hocar

We describe a rare case of DRESS syndrome in a 55-year-old patient who was hospitalized for a cardiac arrhythmia requiring the introduction of acenocoumarol. Three weeks after taking acenocoumarol, the patient developed a generalized morbiliform maculopapular exanthema, surmounted by petechial purpuric lesions on the back, trunk and both lower limbs, associated with facial edema and a fever of 38.1°, with no clinically palpable adenopathies. Biological tests revealed hypeosinophilia and major hepatic cytolysis. According to the REGISCAR (Registry of Severe Cutaneous Adverse Reaction) score at 5 based on the clinical and biological aspects concomitant with drug intake, we retained the diagnosis of DRESS syndrome induced by acenocoumarol intake. The patient was treated with oral and topical cotricotherapy with good clinical and biological improvement.

我们描述了一例罕见的DRESS综合征，患者为55岁，因心律失常住院，需要使用阿塞诺古玛罗。服用阿塞诺古美尔3周后，患者出现全身性病状黄斑丘疹，背部、躯干及双下肢出现点状紫癜性病变，伴有面部水肿，发热38.1°，临床无可触及的腺病。生物学试验显示嗜酸性细胞增多和肝细胞溶解。根据REGISCAR （Registry of Severe Cutaneous Adverse Reaction，严重皮肤不良反应登记）基于药物摄入的临床和生物学方面评分为5分，我们保留了阿塞诺古玛罗摄入引起的DRESS综合征的诊断。患者经口服和局部cotrictherapy治疗，临床和生物学均有良好改善。

引用次数: 0

Sébastien Lefèvre (1976–2025) 塞巴斯蒂安·勒费夫尔（1976—2025）

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-11-01 DOI: 10.1016/j.reval.2025.104622

Le bureau de la Société française d’allergologie et le comité de rédaction de la Revue française d’allergologie

引用次数: 0

Measles–mumps–rubella vaccine in children with food allergies 食物过敏儿童的麻疹-腮腺炎-风疹疫苗

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-10-01 DOI: 10.1016/j.reval.2025.104617

H. Yağmur , Ö. Atay , S. Asilsoy , N. Uzuner

引用次数: 0

Measles–Mumps–Rubella vaccine and cow's milk allergy 麻疹-腮腺炎-风疹疫苗和牛奶过敏

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-10-01 DOI: 10.1016/j.reval.2025.104616

Ö. Özdemir

引用次数: 0

Eculizumab-Induced Stevens-Johnson Syndrome: The first pediatric case report in the literature 依曲单抗诱导的史蒂文斯-约翰逊综合征：文献中的第一例儿科病例报告

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-09-25 DOI: 10.1016/j.reval.2025.104602

Ş.İ. Kökcü Karadağ , D. Tekcan , H. Nalçacıoğlu , Ö. Aydoğ , F. Öztürk

Stevens-Johnson Syndrome is a severe mucocutaneous disease that frequently arises in response to medications and is rarely observed. To our knowledge, we report the first pediatric case of SJS induced by Eculizumab, documenting the potential risks associated with this treatment in children and making a significant contribution to the medical literature. A three-year old male patient diagnosed with atypical hemolytic uremic syndrome and treated with Eculizumab exhibited classical symptoms of SJS shortly after receiving his fourth dose. These symptoms included severe oral and labial ulcers, conjunctival hyperemia, and extensive erythematous macular rashes. Initial laboratory tests revealed an abnormal white blood cell count and elevated inflammatory markers, with a subsequent skin biopsy confirming SJS. Immediate initiation of intravenous steroid therapy resulted in substantial improvement in the patient. This report underscores the critical importance of early recognition and management of SJS, particularly in pediatric patients receiving monoclonal antibody therapy. The key lessons highlight the need for healthcare providers to remain vigilant about this rare but potentially fatal adverse effect, and to promptly discontinue treatment and intervene effectively to improve patient outcomes.

史蒂文斯-约翰逊综合征是一种严重的皮肤粘膜疾病，经常出现在药物反应中，很少观察到。据我们所知，我们报告了第一例由Eculizumab引起的儿童SJS病例，记录了与该治疗相关的儿童潜在风险，并对医学文献做出了重大贡献。一名被诊断为非典型溶血性尿毒症综合征的三岁男性患者接受Eculizumab治疗后，在接受第四次剂量后不久出现了典型的SJS症状。这些症状包括严重的口腔和唇溃疡、结膜充血和广泛的红斑性黄斑疹。最初的实验室检查显示白细胞计数异常和炎症标志物升高，随后的皮肤活检证实SJS。立即开始静脉注射类固醇治疗导致患者的病情有了实质性的改善。该报告强调了早期识别和管理SJS的重要性，特别是在接受单克隆抗体治疗的儿科患者中。关键的经验教训强调，卫生保健提供者需要对这种罕见但可能致命的不良反应保持警惕，并及时停止治疗并进行有效干预，以改善患者的预后。

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引用次数: 0

Early-onset serum sickness-like reaction: Role of drug provocation tests in diagnosis 早发性血清病样反应：药物激发试验在诊断中的作用

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-09-25 DOI: 10.1016/j.reval.2025.104603

B.C. Duran, E. Bahadir, S. Demirsöz, C. Aytekin, S. Özmen

Serum sickness-like reaction (SSLR) is a rare, non-IgE-mediated hypersensitivity reaction typically occurring in early childhood, characterized by nonspecific symptoms such as rash, fever, and joint involvement. Although symptoms generally emerge 5–21 days after drug exposure, earlier onset may occur in sensitized individuals upon repeated exposure to the same agent. We report the case of a 5-year old boy who developed fever, erythema, and extremity pain within 12 hours of a drug provocation test (DPT) with amoxicillin-clavulanic acid (ACA). A second DPT performed one month later triggered similar symptoms within 3 hours, confirming the diagnosis of SSLR. Laboratory findings supported systemic inflammation, and the symptoms resolved with corticosteroid treatment. This case highlights the variability in SSLR symptom onset and emphasizes the potential utility of DPT in selected cases to confirm the diagnosis and avoid unnecessary drug elimination. It also draws attention to the need for careful patient selection and standardized protocols when performing DPT in suspected SSLR.

血清疾病样反应（SSLR）是一种罕见的非ige介导的超敏反应，通常发生在儿童早期，以非特异性症状为特征，如皮疹、发热和关节受累。虽然症状通常在药物接触后5-21天出现，但在反复接触同一药物的致敏个体中，症状可能出现得更早。我们报告的情况下，一个5岁的男孩谁出现发烧，红斑和四肢疼痛的药物激发试验（DPT）与阿莫西林-克拉维酸（ACA） 12小时内。一个月后进行的第二次DPT在3小时内引发了类似的症状，证实了SSLR的诊断。实验室结果支持全身性炎症，经皮质类固醇治疗后症状消失。本病例强调了SSLR症状发作的可变性，并强调了DPT在特定病例中的潜在效用，以确认诊断并避免不必要的药物消除。它还提请注意，在疑似SSLR实施DPT时，需要仔细选择患者和标准化方案。

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引用次数: 0

L’allergie à l’arachide. État des lieux et perspectives, par le GT2A. Partie 1 : épidémiologie et fardeau de l’allergie à l’arachide 对花生过敏。状态和前景，由GT2A。第一部分：花生过敏的流行病学和负担

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-08-16 DOI: 10.1016/j.reval.2025.104567

G. Pouessel , A. Deschildre , F. Amat , M. Morisset , V. Jubin , pour le Groupe de travail allergie alimentaire de la Société française d’allergologie

This article is a non-systematic review on the epidemiology and burden of peanut allergy. Peanut allergy is one of the most common IgE-mediated food allergies in children, with an estimated prevalence in France of 0.9% at the age of 5.5 years based on questionnaires from the ELFE cohort. Peanut allergy begins in 90% of cases before the age of 3 years and spontaneously regresses in only 20 to 25% of cases before adulthood. Peanut allergy is associated with sensitization to one or more other legumes in two thirds of cases, and sometimes with a cross-allergy. Patients with peanut allergy most often have associated atopic comorbidities, particularly asthma. Peanut is one of the most common allergens involved in severe and even fatal food anaphylaxis and is associated with a high risk of allergy recurrence. Peanut allergy leads to impaired quality of life and has a significant psychosocial impact. Peanut-allergic patients probably have a different phenotype than patients with other food allergies. Multidisciplinary care and a personalized treatment strategy should be considered in these patients.

本文是一篇关于花生过敏的流行病学和负担的非系统综述。花生过敏是儿童中最常见的ige介导的食物过敏之一，根据ELFE队列的问卷调查，估计法国5.5岁儿童的患病率为0.9%。90%的花生过敏病例在3岁前开始，只有20%至25%的病例在成年前自行消退。在三分之二的病例中，花生过敏与对一种或多种其他豆类的过敏有关，有时还伴有交叉过敏。花生过敏患者通常伴有特应性合并症，尤其是哮喘。花生是最常见的过敏原之一，涉及严重甚至致命的食物过敏反应，并与过敏复发的高风险有关。花生过敏导致生活质量受损，并具有显著的社会心理影响。花生过敏的患者可能与其他食物过敏的患者有不同的表型。这些患者应考虑多学科护理和个性化治疗策略。

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引用次数: 0

Les effets indésirables suite à l’injection de la fluorescéine pour la réalisation de l’angiographie rétinienne : rapport de 4 cas 注射荧光素进行视网膜血管造影的不良反应：4例报告

IF 0.3 4区医学

Revue Francaise d Allergologie

Pub Date : 2025-08-11 DOI: 10.1016/j.reval.2025.104598

N. Taouri, A. Amazouzi, N. Boutimzine, O. Cherkaoui

Fluorescein retinal angiography is a very well tolerated test; however adverse reactions of various severity have been reported, ranging from simple nausea to anaphylactic shock. Nausea, followed by vomiting are the most common anaphylactic incident after fluorescein injection. Premedication is sometimes indicated for patients at risk. Some authors propose desensitization protocols before carrying out an examination, while others propose as an alternative a retinal angiography with oral fluorescein, and sometimes the use of OCT (optical coherence tomography), or OCT-A (optical coherence tomography angiography). Finally, for more safety, it is important to equip the examination room with the necessary tools to manage this type of reactions. We report a retrospective study of 4 cases of adverse reaction following the injection of fluorescein for retinal angiography.

荧光素视网膜血管造影是一种耐受性很好的检查；然而，各种严重程度的不良反应已被报道，从简单的恶心到过敏性休克。恶心、呕吐是荧光素注射后最常见的过敏反应。有风险的患者有时需要预先用药。一些作者建议在进行检查之前进行脱敏治疗，而另一些人则建议使用口服荧光素进行视网膜血管造影，有时使用OCT（光学相干断层扫描）或OCT- a（光学相干断层扫描血管造影）。最后，为了更安全，为检查室配备必要的工具来管理这类反应是很重要的。我们报告了4例视网膜血管造影注射荧光素后不良反应的回顾性研究。

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