Pub Date : 2025-08-27DOI: 10.1038/s41583-025-00968-5
Nicole C. Rust
As a group, our scientific community has a responsibility to unpack the ‘what’ and ‘why’ behind our work for the public, not least because much of our research is publicly funded. Here, I argue that alongside this important service, there are less apparent and perhaps even more motivating reasons to engage in science communication. I also offer some tips on getting started.
{"title":"The unexpected value of communicating science to the public","authors":"Nicole C. Rust","doi":"10.1038/s41583-025-00968-5","DOIUrl":"10.1038/s41583-025-00968-5","url":null,"abstract":"As a group, our scientific community has a responsibility to unpack the ‘what’ and ‘why’ behind our work for the public, not least because much of our research is publicly funded. Here, I argue that alongside this important service, there are less apparent and perhaps even more motivating reasons to engage in science communication. I also offer some tips on getting started.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"572-573"},"PeriodicalIF":26.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-27DOI: 10.1038/s41583-025-00969-4
Julia Sacher, Ingo Bechmann
Far from being a niche concern, women’s brain health is a global issue, affecting more than half of the world’s population. Despite this, the unique aspects of how the female brain adapts, reorganizes and ages, particularly those shaped by hormonal transitions across the lifespan, have not received proportionate attention in research agendas, funding priorities or clinical guidelines.
{"title":"Rethinking women’s brain health","authors":"Julia Sacher, Ingo Bechmann","doi":"10.1038/s41583-025-00969-4","DOIUrl":"10.1038/s41583-025-00969-4","url":null,"abstract":"Far from being a niche concern, women’s brain health is a global issue, affecting more than half of the world’s population. Despite this, the unique aspects of how the female brain adapts, reorganizes and ages, particularly those shaped by hormonal transitions across the lifespan, have not received proportionate attention in research agendas, funding priorities or clinical guidelines.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"576-578"},"PeriodicalIF":26.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-26DOI: 10.1038/s41583-025-00967-6
Megan R. Carey
The scientific enterprise depends on attracting and retaining the very best talent, yet barriers persist that perpetuate inequities in the scientific workforce. Here I discuss the efforts of the ALBA Network to help anyone to work effectively to maximize scientific progress by making their communities more equitable and inclusive.
{"title":"Working together to build strong scientific communities","authors":"Megan R. Carey","doi":"10.1038/s41583-025-00967-6","DOIUrl":"10.1038/s41583-025-00967-6","url":null,"abstract":"The scientific enterprise depends on attracting and retaining the very best talent, yet barriers persist that perpetuate inequities in the scientific workforce. Here I discuss the efforts of the ALBA Network to help anyone to work effectively to maximize scientific progress by making their communities more equitable and inclusive.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"574-575"},"PeriodicalIF":26.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-20DOI: 10.1038/s41583-025-00965-8
Ann Kennedy
The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine the use of top-down conceptual and bottom-up mechanistic models in theoretical neuroscience, exploring how they connect with experimental practice and where there is room for future growth.
{"title":"Theoretical neuroscience has room to grow","authors":"Ann Kennedy","doi":"10.1038/s41583-025-00965-8","DOIUrl":"10.1038/s41583-025-00965-8","url":null,"abstract":"The goal of theoretical neuroscience is to uncover principles of neural computation through careful design and interpretation of mathematical models. Here, I examine the use of top-down conceptual and bottom-up mechanistic models in theoretical neuroscience, exploring how they connect with experimental practice and where there is room for future growth.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"585-586"},"PeriodicalIF":26.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-20DOI: 10.1038/s41583-025-00964-9
Nina M. Rzechorzek
In this Journal Club, Nina Rzechorzek explores a 2003 article showing that, during hibernation, ground squirrels reversibly accumulate highly phosphorylated tau in the brain (a hallmark of Alzheimer’s disease) without developing neurofibrillary tangle pathology.
{"title":"Brain on standby — how torpor made ‘tauopathy’ reversible","authors":"Nina M. Rzechorzek","doi":"10.1038/s41583-025-00964-9","DOIUrl":"10.1038/s41583-025-00964-9","url":null,"abstract":"In this Journal Club, Nina Rzechorzek explores a 2003 article showing that, during hibernation, ground squirrels reversibly accumulate highly phosphorylated tau in the brain (a hallmark of Alzheimer’s disease) without developing neurofibrillary tangle pathology.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"590-590"},"PeriodicalIF":26.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-19DOI: 10.1038/s41583-025-00962-x
Benjamin R. Cowley
In this Journal Club, Benjamin Cowley discusses a 2009 tour-de-force that provided a recipe for constructing closed-loop algorithms by letting predictive models speak for themselves.
{"title":"Time to let the model speak for itself with closed-loop neurophysiology","authors":"Benjamin R. Cowley","doi":"10.1038/s41583-025-00962-x","DOIUrl":"10.1038/s41583-025-00962-x","url":null,"abstract":"In this Journal Club, Benjamin Cowley discusses a 2009 tour-de-force that provided a recipe for constructing closed-loop algorithms by letting predictive models speak for themselves.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"589-589"},"PeriodicalIF":26.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-18DOI: 10.1038/s41583-025-00963-w
Olivia M. S. Gold
In this Journal Club, Olivia Gold discusses a 2003 study showing in rats that respiratory depression caused by the synthetic opioid fentanyl could be pharmacologically reversed without compromising its analgesic effects.
{"title":"Looking for inspiration in the opioid era","authors":"Olivia M. S. Gold","doi":"10.1038/s41583-025-00963-w","DOIUrl":"10.1038/s41583-025-00963-w","url":null,"abstract":"In this Journal Club, Olivia Gold discusses a 2003 study showing in rats that respiratory depression caused by the synthetic opioid fentanyl could be pharmacologically reversed without compromising its analgesic effects.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 11","pages":"659-659"},"PeriodicalIF":26.7,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-13DOI: 10.1038/s41583-025-00957-8
Davi D. Bock
High-throughput volume electron microscopy and deep learning-driven automated segmentation have revolutionized the mapping of neural circuits at the level of individual neurons and synapses, revealing new cell types and unexpected network architectures in diverse species. Although prospects for continued progress in connectomics are excellent, substantial technical and conceptual hurdles remain.
{"title":"Synaptic connectomics: status and prospects","authors":"Davi D. Bock","doi":"10.1038/s41583-025-00957-8","DOIUrl":"10.1038/s41583-025-00957-8","url":null,"abstract":"High-throughput volume electron microscopy and deep learning-driven automated segmentation have revolutionized the mapping of neural circuits at the level of individual neurons and synapses, revealing new cell types and unexpected network architectures in diverse species. Although prospects for continued progress in connectomics are excellent, substantial technical and conceptual hurdles remain.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"581-582"},"PeriodicalIF":26.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-11DOI: 10.1038/s41583-025-00958-7
Mengting Han
In this Tools of the Trade article, Mengting Han discusses the development of CRISPR-TO, a programmable method for perturbing endogenous RNA localization, and its use for functional screening of the spatial transcriptome in neurons.
{"title":"CRISPR-TO: a versatile tool for programmable control of the spatial transcriptome","authors":"Mengting Han","doi":"10.1038/s41583-025-00958-7","DOIUrl":"10.1038/s41583-025-00958-7","url":null,"abstract":"In this Tools of the Trade article, Mengting Han discusses the development of CRISPR-TO, a programmable method for perturbing endogenous RNA localization, and its use for functional screening of the spatial transcriptome in neurons.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"587-587"},"PeriodicalIF":26.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-11DOI: 10.1038/s41583-025-00959-6
Sian Lewis
In this study, flagellin, a highly conserved microbe-associated molecular pattern that increases after meals, is shown to activate TLR5 receptors expressed by neurpod cells in the colonic epithelium that signal to the brain via PYY release and vagal activation and influence feeding behaviour.
{"title":"A gut instinct for microbial patterns","authors":"Sian Lewis","doi":"10.1038/s41583-025-00959-6","DOIUrl":"10.1038/s41583-025-00959-6","url":null,"abstract":"In this study, flagellin, a highly conserved microbe-associated molecular pattern that increases after meals, is shown to activate TLR5 receptors expressed by neurpod cells in the colonic epithelium that signal to the brain via PYY release and vagal activation and influence feeding behaviour.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 11","pages":"658-658"},"PeriodicalIF":26.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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