Ticks and Tick-borne Diseases最新文献_第10页

Sympatric occurrence of Ixodes ricinus, Haemaphysalis concinna and Haemaphysalis inermis in a wild fauna reserve 野生动物保护区内蓖麻蜱、麻血蜱和残血蜱的同域分布

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-06-04 DOI: 10.1016/j.ttbdis.2025.102491

Héloïse Duchêne , Albert Agoulon , Nathalie de la Cotte , Claire Bonsergent , Maggy Jouglin , Barbara Blanc , Alice Brunet , Katia Ortiz , Suzanne Bastian , Laurence Malandrin

Wildlife reserves represent confined ecosystems with a high concentration of non-native animal species. The Réserve Zoologique de la Haute Touche, a unique forested environment, houses approximately 50 species, primarily Artiodactyla and Perissodactyla. We conducted a comprehensive tick survey within the reserve in 2017, collecting ticks from vegetation by flagging (outside enclosures on 101 sampling points in May and September, inside 21 enclosures in May), by visual search outside enclosures in May, and directly on animals captured for routine veterinary interventions, over four consecutive years (2015–2018).

A total of 13,038 questing ticks, representing seven species, were collected via flagging outside and inside enclosures. Ixodes ricinus (88.9%), Haemaphysalis concinna (10.1 %), and Haemaphysalis inermis (1 %) were the dominant species, with all three parasitic life stages of these species found in May. The less common species were Ixodes acuminatus (2 nymphs), Ixodes frontalis (2 nymphs), Dermacentor reticulatus (3 adults), and Dermacentor marginatus (1 adult). Ixodes ricinus was ubiquitous throughout the reserve, outside and inside enclosures, at nearly all sampling sites (100/101 and 9/21 enclosures), followed by H. concinna (78/101 sites and 6/21 enclosures) and H. inermis (49/101 sites and 1/21 enclosures). Tick densities varied greatly with peak densities reaching 1221 I. ricinus nymphs per 100 m² and 46 I. ricinus adults per 100 m² in May. Haemaphysalis concinna densities reached 124 nymphs per 100 m². Visual searches for adult ticks on vegetation revealed statistically different proportions of these three species between different areas of the reserve, with H. inermis reaching 40.5 % of the collected adults in a specific area. Enclosures housing roe deer (Capreolus capreolus) and red deer (Cervus elaphus) exhibited the highest tick abundance on vegetation. Feeding ticks, including I. ricinus (n = 53), H. concinna (n = 26), and D. reticulatus (n = 1), were collected from 15 animals of six ruminant species.

This study represents the first documented sympatric occurrence of I. ricinus, H. concinna, and H. inermis in France, and the first description of Haemaphysalis species within a zoological reserve. The potential for pathogen transmission by these three generalist species and especially Haemaphysalis species (paucity of data) warrants further investigation.

野生动物保护区是一种非本地动物物种高度集中的封闭生态系统。r serve Zoologique de la Haute Touche是一个独特的森林环境，拥有大约50个物种，主要是偶蹄动物和短蹄动物。2017年，我们在保护区内进行了全面的蜱虫调查，在连续四年（2015-2018）中，通过标记（5月和9月在101个围场外采样点，5月在21个围场内），5月在围场外视觉搜索，以及直接在常规兽医干预下捕获的动物身上收集蜱虫。通过在室外和室内进行标记，共收集了7个物种的13038只蜱虫。优势种为蓖麻硬蜱（88.9%）、粗血蜱（10.1%）和无血蜱（1%），3个寄生期均在5月份。较少见的种为尖革蜱（2只若虫）、额革蜱（2只若虫）、网状革蜱（3只成虫）和边缘革蜱（1只成虫）。在100/101和9/21个圈地中，蓖麻伊蚊在保护区内外均普遍存在，其次是麻伊蚊（78/101和6/21个圈地）和麻伊蚊（49/101和1/21个圈地）。蜱虫密度变化较大，5月最高密度为每100 m²1221只蓖麻螨蛹和每100 m²46只成虫。血蜱密度达到每100平方米124若虫。在植被上的目视搜索显示，在保护区不同区域，这三种蜱的比例有统计学差异，在特定区域，寄生蜂的比例达到40.5%。黄鹿（Capreolus Capreolus Capreolus）和马鹿（Cervus elaphus）围场对植被的蜱虫丰度最高。从6种反刍动物15只身上采集食性蜱，其中蓖麻蜱53只、粗腹蜱26只、网状蜱1只。这项研究首次记录了蓖麻蜱、麻毒蜱和寄生蜂在法国的同域分布，并首次描述了动物保护区内的血蜱物种。这三种多面手种，特别是血蜱种传播病原体的可能性（缺乏数据）值得进一步调查。

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引用次数: 0

Clinical characteristics of and diagnostic approaches to human Francisella tularensis infection: a retrospective, monocentric case study from Germany 人类土拉菌感染的临床特征和诊断方法：来自德国的回顾性单中心病例研究

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-06-03 DOI: 10.1016/j.ttbdis.2025.102492

Sophie E. Müller , Sophie Schneitler , Sabine Zange , Maximilian Linxweiler , Arne Simon , Lorenz Thurner , Sören L. Becker

Francisella tularensis, the causative agent of tularemia, poses a challenge for diagnosis and treatment due to its diverse clinical presentations and low incidence. Hence, the awareness among clinicians is comparatively low. This study reports the clinical characteristics, diagnostic approaches, and treatment outcomes of tularemia cases at one tertiary center in Germany over a 12-yearperiod.

This retrospective monocentric case series considered all tularemia cases diagnosed at Saarland University Medical Center in Homburg, Germany between January 2013 and December 2024. Cases were identified from electronic medical records, and the certainty of tularemia was graded as definite, probable and possible infection, based on results of serology, polymerase chain reaction (PCR) assays, or blood cultures. Clinical data were extracted from patient records and supplemented by follow-up information from the clinicians.

We identified 14 tularemia cases, including 6 definite as well as 3 probable and 5 possible cases. The clinical presentation was highly variable, with the (ulcero-)glandular form being the most common entity (10/14). Invasive diagnostics or surgery were required in eleven out of 14 patients. Initial misdiagnosis was common, leading to delayed diagnosis and multiple courses of ineffective antibiotics. Definite treatment included fluoroquinolones or doxycycline, and led to resolution of symptoms in most patients.

The varied clinical manifestations of tularemia, from classic (ulcero-)glandular forms to severe and atypical presentations illustrate its diagnostic and clinical complexity. Enhanced awareness and early consideration are crucial, especially in endemic areas or patients with anamnestic environmental exposures.

土拉菌是引起土拉菌病的病原体，其临床表现多样，发病率低，给诊断和治疗带来了挑战。因此，临床医生的认识相对较低。本研究报告了德国一家三级医疗中心12年来兔热病病例的临床特征、诊断方法和治疗结果。本回顾性单中心病例系列研究了2013年1月至2024年12月期间在德国洪堡萨尔大学医学中心诊断的所有兔热病病例。从电子病历中确定病例，根据血清学、聚合酶链反应（PCR）检测或血培养结果，将兔热病的确定性分为确定、可能和可能感染。临床数据从患者记录中提取，并辅以临床医生的随访信息。共发现14例兔热病，其中确诊6例，可能3例，可能5例。临床表现变化很大，最常见的是（溃疡）腺体形式（10/14）。14例患者中有11例需要进行侵入性诊断或手术。最初的误诊是常见的，导致延误诊断和多个疗程无效的抗生素。明确的治疗包括氟喹诺酮类药物或强力霉素，大多数患者的症状得到缓解。兔热病的不同临床表现，从典型的（溃疡）腺形式到严重和不典型的表现，说明了其诊断和临床的复杂性。提高认识和早期考虑是至关重要的，特别是在流行地区或有遗忘性环境暴露的患者。

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引用次数: 0

Quantitative detection of Theileria haneyi in South African horses 南非马中黑氏芽孢杆菌的定量检测

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.ttbdis.2025.102487

Raksha V. Bhoora, Tshenolo V. Mbaba, Milana Troskie, Rebecca E. Ackermann, Nicola E. Collins

Theileria haneyi is an apicomplexan parasite closely related to Theileria equi, a known causative agent of equine piroplasmosis. The molecular distinction between these parasites relies on a nested polymerase chain reaction (PCR) assay, which has been reported to be unreliable. A recently reported indirect ELISA based on equi merozoite antigen 11 (Thema-11) of T. haneyi can detect geographically diverse T. haneyi strains. Since the ema-11 gene is exclusive to T. haneyi, it was chosen as the target for developing a TaqMan minor groove binder (MGB™) quantitative real-time PCR (qPCR). Published T. haneyi ema-11 gene sequences were used to design primers to amplify the ema-11 gene, and ema-11 amplicons from South African samples were cloned and sequenced. An alignment of the South African ema-11 gene sequences with published T. haneyi ema-11 gene sequences enabled the identification of a conserved region for the design of the qPCR assay. The T. haneyi ema-11 (Thema-11) qPCR assay was efficient, specific, and sensitive in detecting T. haneyi ema-11. The detection limit was determined to be 1.169 × 10^–3 % parasitized erythrocytes. The performance of the Thema-11 qPCR assay was evaluated together with a T. equi ema-1-specific qPCR assay. Theileria haneyi was detected in 67.6 % of the South African field samples screened, while the occurrence of T. equi based on the quantitative amplification of the ema-1 gene was higher (91.8 %). Our results suggest that combined, the Thema-11 and T. equi ema-1 qPCR assays could detect and differentiate between T. haneyi and T. equi infections.

哈尼伊勒菌是一种顶端复合体寄生虫，与马勒菌密切相关，马勒菌是已知的马螺旋体病病原体。这些寄生虫之间的分子区分依赖于巢式聚合酶链反应（PCR）测定，据报道这是不可靠的。最近报道的一种基于哈尼伊T. merozoite抗原11 （therma -11）的间接酶联免疫吸附试验可以检测不同地理位置的哈尼伊T.菌株。由于ma-11基因是T. haneyi独有的，因此选择它作为开发TaqMan次要凹槽结合物（MGB™）定量实时PCR （qPCR）的目标。利用已发表的T. haneyi ema-11基因序列设计引物扩增ema-11基因，并对来自南非样本的ema-11扩增子进行克隆和测序。将南非的ema-11基因序列与已发表的T. haneyi ema-11基因序列比对，可以确定一个保守区域，用于设计qPCR检测。哈尼伊T. ma-11 (Thema-11) qPCR检测哈尼伊T. ma-11高效、特异、敏感。检出限为1.169 × 10 - 3%。将Thema-11 qPCR检测的性能与T. equi ma-1特异性qPCR检测一起进行评估。在南非筛选的田间样本中检出了67.6%的哈尼氏滴虫，而基于ema-1基因定量扩增的equi滴虫的检出率更高（91.8%）。我们的结果表明，theta -11和T. equi ma-1 qPCR联合检测可以检测和区分T. haneyi和T. equi感染。

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引用次数: 0

Diversity and prevalence of spotted-fever group rickettsiae in ixodid ticks across Slovakia, Central Europe 中欧斯洛伐克境内蜱虫中斑点热群立克次体的多样性和流行

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.ttbdis.2025.102490

Ivana Heglasová , Bronislava Víchová , Michal Stanko

Habitats with the sympatric occurrence of several ixodid tick species are significant from an epidemiological perspective. These habitats can influence the diversity and prevalence of tick-borne pathogens, and their monitoring can help estimate the risk of infection. A total of 1260 questing ticks from five species (Ixodes ricinus, Dermacentor marginatus, Dermacentor reticulatus, Haemaphysalis concinna, and Haemaphysalis inermis) were collected from vegetation using the flagging method in three different habitats in eastern Slovakia. Additionally, 900 rodent-attached ticks of six species (I. ricinus, Ixodes trianguliceps, D. marginatus, D. reticulatus, H. concinna, and H. inermis) collected from 149 small mammals belonging to seven species (Apodemus flavicollis, Apodemus agrarius, Microtus arvalis, Myodes glareolus, Micromys minutus, Crocidura leucodon, and Crocidura suaveolens) were selected for molecular analyses. DNA obtained from rodent-attached and questing ticks was tested by nested PCR targeting the gltA gene to determine the presence of Rickettsia spp. The ompA, ompB, and sca4 genes were amplified and sequenced to identify rickettsiae species. The overall prevalence of rickettsiae in questing and rodent-attached ticks was 12.5 % and 20.0 %, respectively. Overall studied localities, the most diverse spectrum of rickettsiae species, including R. helvetica, R. monacensis, R. raoultii, and R. slovaca, was recorded in questing and rodent-attached ticks in the natural habitat of the Slovak Karst. The dominant species, R. helvetica (62.9 %), was identified in two species of questing and rodent-attached ticks, specifically I. ricinus and H. concinna, and in rodent-attached D. reticulatus ticks. Rickettsia raoultii (20.4 %) was identified in questing and rodent-attached D. marginatus, D. reticulatus, and in questing H. concinna. Additionally, this study provides the first input of pathogenic R. raoultii in I. trianguliceps obtained from the striped field mouse (A. agrarius). Rickettsia monacensis (9.0 %) was detected in questing and rodent-attached I. ricinus, while Rickettsia slovaca (3.6 %) was found in questing and rodent-attached D. marginatus ticks. Natural biotopes with different tick species and hosts significantly affect the diversity and prevalence of rickettsiae.

从流行病学角度看，几种蜱类同地分布的生境具有重要意义。这些栖息地可以影响蜱传病原体的多样性和流行，对它们的监测可以帮助估计感染的风险。采用标记法在斯洛伐克东部3个不同生境的植被上共采集到蓖麻蜱、边缘革蜱、网状革蜱、细血蜱和无血蜱5种蜱1260只。选取7种149只小型兽类（黄斑姬鼠、黑线姬鼠、小仓鼠、光斑姬鼠、小仓鼠、小仓鼠、小仓鼠、小仓鼠、小仓鼠、分钟仓鼠、白纹仓鼠、小仓鼠）6种（蓖麻蜱、三角仓鼠、边缘仓鼠、网纹仓鼠、细仓鼠、小仓鼠）的900只啮齿蜱进行分子分析。采用巢式PCR方法检测附鼠蜱和寻鼠蜱的gltA基因，并扩增ompA、ompB和sca4基因序列，确定立克次体的种类。调查蜱和附鼠蜱中立克次体总体流行率分别为12.5%和20.0%。总体而言，在斯洛伐克喀斯特自然生境中，立克次体物种分布最为多样，包括helvetica、monacensis、raoultii和slovaca立克次体。在捕鼠蜱和贴鼠蜱（蓖麻蜱和灰蜱）和网纹蜱（贴鼠蜱）中，均鉴定出优势种helvetica（62.9%）。在猎鼠和附鼠的边缘田鼠、网纹田鼠和猎鼠鼠中鉴定出拉乌尔立克次体（20.4%）。此外，本研究提供了从条纹田鼠（A. agrarius）获得的三角纹田鼠（I. trianguliceps）中首次输入致病性拉乌尔氏伊蚊。在捕鼠和附鼠的蓖麻蜱中检出单纳克次体（9.0%），在捕鼠和附鼠的边缘蜱中检出慢行立克次体（3.6%）。不同蜱类和寄主的自然生态环境对立克次体的多样性和流行率有显著影响。

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引用次数: 0

Epidemiological study on the prevalence of Anaplasma ovis infection in Aragón, Spain 西班牙Aragón地区羊无原体感染流行病学研究

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.ttbdis.2025.102486

Héctor Ruiz , José María González , Marta Ruiz de Arcaute , Sergio Villanueva-Saz , Juan José Ramos , José Luis Arnal , Cristina Baselga , Pablo Quilez , Aurora Ortín , Delia Lacasta

Ovine anaplasmosis is an emerging disease in Europe, primarily affecting the Mediterranean region. It is caused by Anaplasma ovis, a bacterium mainly transmitted by ticks. Despite its growing presence, comprehensive data on its distribution across Europe remain scarce. This epidemiological study aimed to assess the prevalence of A. ovis in sheep farms across Aragón, Spain, between March 2023 and April 2024. A total of 70 farms, covering a diverse range of climatic zones within Aragón, were sampled, representing 700 sheep. Two pooled blood samples, each comprising five sheep per farm, were tested using quantitative PCR (qPCR) to detect the presence of A. ovis. The results revealed a widespread presence of the bacterium, with 69 out of 70 farms testing positive. The only negative case was a farm located in a Steppe Dry climate area near Zaragoza, at approximately 240 m above sea level. Notably, no clinical signs of the disease were observed in any of the animals during the study period. In addition to the high prevalence, the study highlighted a concerning lack of awareness among farmers, with only 33 % reporting familiarity with the disease. These findings underscore the extensive distribution of A. ovis in Aragón and suggest that neither climatic conditions nor livestock management practices had a significant influence on transmission. The study also emphasizes the urgent need for enhanced control measures, increased farmer education, and further research into environmental and management factors that may contribute to outbreaks.

绵羊无形体病是欧洲的一种新发疾病，主要影响地中海地区。它是由鹅无原体引起的，一种主要由蜱虫传播的细菌。尽管它的存在越来越多，但有关其在欧洲分布的全面数据仍然很少。本流行病学研究旨在评估2023年3月至2024年4月期间西班牙Aragón地区绵羊养殖场的羊链球菌流行情况。总共有70个农场，覆盖了Aragón不同的气候带，代表了700只羊。使用定量PCR （qPCR）检测了两个汇集的血液样本，每个农场包括5只羊，以检测山羊单胞杆菌的存在。结果显示这种细菌广泛存在，70个农场中有69个检测呈阳性。唯一的阴性案例是位于萨拉戈萨附近干燥草原气候区的一个农场，海拔约240米。值得注意的是，在研究期间，没有任何动物出现这种疾病的临床症状。除了发病率高外，该研究还强调了农民对该病缺乏认识的问题，只有33%的农民报告熟悉该病。这些发现强调了在Aragón的广泛分布，并表明气候条件和牲畜管理方法对传播都没有显著影响。该研究还强调，迫切需要加强控制措施，加强农民教育，并进一步研究可能导致疫情的环境和管理因素。

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引用次数: 0

Corrigendum to “Rodent-targeted fluralaner baiting reduces the density of Borrelia burgdorferi-infected questing Ixodes scapularis ticks in a peri-urban setting in southern Canada” [Ticks Tick Borne Dis 16(2);2025 102467] “以啮齿动物为目标的氟拉烷诱饵减少了加拿大南部城市周边地区感染伯氏疏螺旋体的鳞片蜱的密度”[蜱虫蜱传疾病16(2);2025 102467]。

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.ttbdis.2025.102489

Jérôme Pelletier , Jean-Philippe Rocheleau , Catherine Bouchard , Geneviève Baron , Heather Coatsworth , Antonia Dibernardo , Christopher Fernandez-Prada , Nicholas H Ogden , Liliana Potes , Patrick A Leighton , Cécile Aenishaenslin

引用次数: 0

Tick hazard in a Central European country: Mapping Europe’s principal tick-borne disease vector across Germany 中欧国家的蜱虫危害：绘制欧洲主要蜱传疾病媒介在德国的地图

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.ttbdis.2025.102485

Andrea Springer , Alexander Lindau , Katrin Fachet-Lehmann , Daniel Kämmer , Ingrid Bulling , Steffen Knoll , Nina Król , Dominik Fischer , Luisa Fischer , Marco Drehmann , Lidia Chitimia-Dobler , Madeleine Noll , Hannah Rose Vineer , Olaf Kahl , Martin Pfeffer , Christina Strube , Ute Mackenstedt

The most common European tick species, Ixodes ricinus, is the principal vector of Borrelia and tick-borne encephalitis virus and several other pathogens of public health relevance in Europe. Comprehensive data on tick abundance and the underlying ecological drivers are crucial for developing awareness and control strategies and to assess future changes in tick-borne disease risk. We aimed to provide a Germany-wide map of I. ricinus abundance to aid in disease transmission risk assessment. During 2018−2020, questing tick density was assessed at 83 sites across the whole country by drag flagging, whereby 49,344 I. ricinus nymphs and adults were collected. Relationships between climate, land cover, and monthly questing I. ricinus nymph density were explored and used to draw an abundance map. Highest tick hazard was observed in areas near the coast with mild winters and moist springs, and in mid-elevation mountain ranges, which represent popular tourist destinations. The ticks’ seasonal activity pattern was predominantly unimodal. The fact that the observed regional differences are contradictory to a previous estimation based on a combination of regional studies illustrates the need for an extensive and coordinated sampling effort to reliably estimate tick abundance at larger spatial scales. Combined with data on tick-borne pathogens, our study enables estimating the density of infected ticks and consequently the risk of acquiring an infectious tick bite. Moreover, the observed relationships with climate and land cover can help to predict future developments of tick hazard under different climate scenarios in Central Europe.

欧洲最常见的蜱种蓖麻伊蚊是伯氏疏螺旋体和蜱传脑炎病毒以及与欧洲公共卫生相关的其他几种病原体的主要媒介。关于蜱虫丰度和潜在生态驱动因素的综合数据对于制定认识和控制战略以及评估蜱传疾病风险的未来变化至关重要。我们的目标是提供德国范围内蓖麻毒素丰富度的地图，以帮助疾病传播风险评估。在2018 - 2020年期间，在全国83个地点采用拖拽标记法评估了蜱虫密度，共收集到49,344只蓖麻蠓稚虫和成虫。研究了气候、土地覆盖和月探测蓖麻若虫密度之间的关系，并绘制了丰度图。蜱虫危害最高的地区为冬季温和、春季湿润的沿海地区和中高海拔山区，这些地区是旅游胜地。蜱的季节性活动模式以单峰为主。观察到的区域差异与先前基于区域研究组合的估计相矛盾，这一事实说明需要进行广泛和协调的抽样工作，以便在更大的空间尺度上可靠地估计蜱虫丰度。结合蜱传病原体的数据，我们的研究能够估计受感染蜱的密度，从而获得传染性蜱叮咬的风险。此外，观测到的与气候和土地覆盖的关系有助于预测中欧不同气候情景下蜱害的未来发展。

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引用次数: 0

Corrigendum to “Effective control of severe fever with thrombocytopenia syndrome in Daishan County, a former epicenter in Zhejiang Province, Southeast China” [Ticks and Tick-borne Diseases 16 (2025) 102481] 《浙江省原疫区岱山县发热伴血小板减少综合征有效控制》[蜱与蜱传疾病16(2025)102481]勘误表。

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-05-01 DOI: 10.1016/j.ttbdis.2025.102484

Qilong Tan , Shuqin Fu , Jiwei Shu , Ying Liu , Yihan Lou , Mingxing Hu , Sen Zhang , Jiangping Ren , Jimin Sun

引用次数: 0

Vaccinomics-driven selection and validation of protective salivary antigens from the argasid tick Ornithodoros moubata 疫苗组学驱动的moubata鸟蜱保护性唾液抗原的选择和验证

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-04-29 DOI: 10.1016/j.ttbdis.2025.102483

Ana Laura Cano-Argüelles, Ana Oleaga, María González-Sánchez, Rocío Vizcaíno-Marín, Ricardo Pérez-Sánchez

Ornithodoros moubata serves as primary vector of African swine fever and tick-borne human relapsing fever in Africa. Developing an effective vaccine targeting this argasid tick would significantly enhance disease control measures. To identify potential vaccine targets, the recently characterised sialome of O. moubata was analysed using a vaccinomics approach. This led to the identification of a set of salivary secreted proteins predicted to be antigenic and implicated in the regulation of blood-feeding and host immune defences. The objective of this study was to evaluate the protective potential of seven of these proteins, namely Complement inhibitor (OmCI), Cyclophilin (OmCPH), Hypothetical protein 275 (OmH275), Peroxiredoxin (OmPXR), Calreticulin (OmCLR), Neprilysin (OmNEP), and Superoxide dismutase (OmSOD). These candidates were produced as recombinant proteins, formulated with Montanide adjuvant, and administered individually to different groups of rabbits. Adult and nymphal-3 specimens of O. moubata and Ornithodoros erraticus (the Mediterranean vector of ASF and TBRF) were allowed to feed on the vaccinated rabbits, and the ticks’ feeding performance, survival, and reproduction rates were assessed. OmH275, OmPXR, OmCPH, and OmCLR conferred 20 %–32 % protection against O. moubata and/or O. erraticus, whereas OmCI, OmNEP, and OmSOD afforded 2 %–17 % protection against one or both tick species. Consequently, OmH275, OmPXR, OmCPH, and OmCLR were deemed suitable candidates for inclusion in the development of anti-Ornithodoros cocktail vaccines, while OmCI, OmNEP, and OmSOD were considered less promising for tick vaccine development. These findings validate the vaccinomics pipeline, identifying four of seven candidates (57 %) as viable antigens for Ornithodoros tick vaccines.

在非洲，摩巴塔鸟是非洲猪瘟和蜱传人类回归热的主要媒介。开发一种有效的针对这种蜱虫的疫苗将大大加强疾病控制措施。为了确定潜在的疫苗靶点，使用疫苗组学方法分析了最近表征的moubata唾液体。这导致了一组唾液分泌蛋白的鉴定，这些蛋白被预测为抗原性的，并涉及血液摄食和宿主免疫防御的调节。本研究的目的是评估补体抑制剂（OmCI）、亲环蛋白（OmCPH）、假设蛋白275 （OmH275）、过氧化物还氧蛋白（OmPXR）、钙网蛋白（OmCLR）、耐药蛋白（OmNEP）和超氧化物歧化酶（OmSOD） 7种蛋白质的保护潜力。这些候选物以重组蛋白的形式生产，与Montanide佐剂配制，并单独给予不同组的兔子。将非洲猪瘟和TBRF地中海病媒moubata O. moubata和Ornithodoros erraticus成虫和幼虫3号标本采食接种疫苗的家兔，评估其采食性能、存活率和繁殖率。OmH275、OmPXR、OmCPH和OmCLR对moubata和/或O. erraticus的保护率为20% - 32%，而OmCI、OmNEP和OmSOD对一种或两种蜱虫的保护率为2% - 17%。因此，OmH275、OmPXR、OmCPH和OmCLR被认为适合用于抗鸟蛾鸡尾酒疫苗的开发，而OmCI、OmNEP和OmSOD被认为不太有希望用于蜱虫疫苗的开发。这些发现证实了疫苗组学途径，确定了7个候选抗原中的4个（57%）作为鸟thodoros蜱疫苗的活抗原。

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引用次数: 0

Effective control of severe fever with thrombocytopenia syndrome in Daishan County, a former epicenter in Zhejiang Province, Southeast China 浙江省岱山县发热伴血小板减少综合征有效防控

IF 3.1 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-04-19 DOI: 10.1016/j.ttbdis.2025.102481

Qilong Tan , Shuqin Fu , Jiwei Shu , Ying Liu , Yihan Lou , Mingxing Hu , Sen Zhang , Jimin Sun , Jiangping Ren

Background

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease with high case fatality rate. In 2016, a series of community-based comprehensive measures were put into effect in Daishan. This study was conducted to explore the change in the epidemiology of SFTS following the implementation of those measures..

Methods

Descriptive and statistical analyses were conducted to characterize the epidemiology of SFTS.

Results

In total, 156 cases were reported in Daishan during 2011–2023, with the average annual incidence rate of 66.58 per million. The incidence increased with age, and the case fatality rate was significantly higher among the cases over 65 years (P < 0.050). After the implementation of the community-based comprehensive measures in 2016, the incidence was remarkably declined from 2015 to 2019 (Annual Percent Change [APC] = -39.98, P < 0.001) and remained relatively stable without significant alteration between 2019 and 2023 (APC = 15.77, P = 0.156), which was in contrast to the trends in Zhejiang and Mainland China. The hospital type that was most frequently visited for the initial medical-seeking shifted from type I (59.26 %) in 2011–2016 to type II (56.52 %) in 2017–2023. The time intervals between first-visiting and confirmation, onset and confirmation were shortened in the period of 2017–2023 (P < 0.001). Consequently, the case fatality was insignificantly reduced (8.70 % vs. 20 %, P = 0.084).

Conclusions

The community-based comprehensive measures are highly efficacious in the containment of SFTS.

背景严重发热伴血小板减少综合征（SFTS）是一种新出现的蜱媒传染病，病死率很高。2016 年，一系列以社区为基础的综合措施在岱山开始实施。结果2011-2023年间，岱山共报告156例，年平均发病率为66.58/万。发病率随年龄增长而增加，65 岁以上病例死亡率明显升高（P < 0.050）。2016年实施社区综合防治措施后，2015年至2019年发病率明显下降（年百分比变化[APC] = -39.98，P <0.001），2019年至2023年保持相对稳定，无明显变化（APC = 15.77，P = 0.156），这与浙江和中国大陆的趋势形成鲜明对比。首次就诊最多的医院类型从2011-2016年的I类（59.26%）转变为2017-2023年的II类（56.52%）。在 2017-2023 年期间，首次就诊与确诊、发病与确诊之间的时间间隔缩短（P <0.001）。因此，病死率显著降低（8.70 % vs. 20 %，P = 0.084）。结论以社区为基础的综合措施在遏制自发性肺结核方面非常有效。

{"title":"Effective control of severe fever with thrombocytopenia syndrome in Daishan County, a former epicenter in Zhejiang Province, Southeast China","authors":"Qilong Tan , Shuqin Fu , Jiwei Shu , Ying Liu , Yihan Lou , Mingxing Hu , Sen Zhang , Jimin Sun , Jiangping Ren","doi":"10.1016/j.ttbdis.2025.102481","DOIUrl":"10.1016/j.ttbdis.2025.102481","url":null,"abstract":"<div><h3>Background</h3><div>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease with high case fatality rate. In 2016, a series of community-based comprehensive measures were put into effect in Daishan. This study was conducted to explore the change in the epidemiology of SFTS following the implementation of those measures..</div></div><div><h3>Methods</h3><div>Descriptive and statistical analyses were conducted to characterize the epidemiology of SFTS.</div></div><div><h3>Results</h3><div>In total, 156 cases were reported in Daishan during 2011–2023, with the average annual incidence rate of 66.58 per million. The incidence increased with age, and the case fatality rate was significantly higher among the cases over 65 years (<em>P</em> < 0.050). After the implementation of the community-based comprehensive measures in 2016, the incidence was remarkably declined from 2015 to 2019 (Annual Percent Change [APC] = -39.98, <em>P</em> < 0.001) and remained relatively stable without significant alteration between 2019 and 2023 (APC = 15.77, <em>P</em> = 0.156), which was in contrast to the trends in Zhejiang and Mainland China. The hospital type that was most frequently visited for the initial medical-seeking shifted from type I (59.26 %) in 2011–2016 to type II (56.52 %) in 2017–2023. The time intervals between first-visiting and confirmation, onset and confirmation were shortened in the period of 2017–2023 (<em>P</em> < 0.001). Consequently, the case fatality was insignificantly reduced (8.70 % vs. 20 %, <em>P</em> = 0.084).</div></div><div><h3>Conclusions</h3><div>The community-based comprehensive measures are highly efficacious in the containment of SFTS.</div></div>","PeriodicalId":49320,"journal":{"name":"Ticks and Tick-borne Diseases","volume":"16 3","pages":"Article 102481"},"PeriodicalIF":3.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0