Ticks and Tick-borne Diseases最新文献_第5页

Checklist and diversity of tick fauna associated with domestic animals in Cambodia 柬埔寨与家畜有关的蜱虫动物群清单和多样性。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102570

Sony Yean , Didot Budi Prasetyo , Theary Ren , Davy Krib , Saoya Sen , Bunthon Chea , Sothyra Tum , Sorn San , Samuth Sum , Sarah Bonnet , Sébastien Boyer

The tick fauna in Cambodia is poorly documented, with limited information on the diversity and distribution of tick species. This study aimed to address this knowledge gap by investigating tick species collected from various hosts, and across different habitats and regions of the country. Tick sampling was conducted in urban areas, rural villages, farms, and forest fringes, with additional samples obtained from a wildlife rescue center, caves, and swiftlet nests. Ticks were collected directly from hosts, as well as on vegetation through flagging methods. Tick species were identified morphologically, and selected specimens were subjected to molecular identification using the cox1 gene. A total of 853 vertebrate hosts representing 13 different animals, including five wildlife, were inspected: buffalo, cats, cattle, chickens, dogs, ducks, goats, goose, pigs, pigeons, pangolins, pythons, and wild pigs. From this first nationwide tick collection, a total of 7,461 ticks were collected, comprising six genera and 14 species of ticks, including seven newly identified species such as Carios batuensis, Dermacentor steini, Dermacentor filippovae, Haemaphysalis canestrinii, Haemaphysalis formosensis, Haemaphysalis hystricis, and Haemaphysalis wellingtoni. Rhipicephalus microplus and Rhipicephalus linnaei were the most predominant tick species collected from cattle and dogs, respectively, whereas no ticks were found on buffaloes, chickens, ducks, goose, pigs or pigeons. Results showed that ticks are widely distributed throughout Cambodia, with particularly rich diversity observed in forest fringes habitats. This study also allowed the number of tick species identified in the country with seven additional species, bringing the total to 26.

柬埔寨的蜱动物群文献很少，关于蜱物种多样性和分布的信息有限。本研究旨在通过调查从不同宿主、不同栖息地和不同地区收集的蜱虫物种来解决这一知识差距。在城市地区、农村、农场和森林边缘进行蜱虫取样，并从野生动物救援中心、洞穴和金丝燕巢穴中获得额外样本。蜱虫直接从寄主身上采集，也可通过标记法在植被上采集。对蜱类进行形态学鉴定，并选取样本进行cox1基因分子鉴定。共有代表13种不同动物的853种脊椎动物宿主接受了检查，其中包括5种野生动物：水牛、猫、牛、鸡、狗、鸭、山羊、鹅、猪、鸽子、穿山甲、蟒蛇和野猪。首次在全国范围内采集蜱类，共采集到蜱类6属14种7,461只，其中新发现的蜱类有巴图金蜱、斯坦金蜱、菲律宾金蜱、canestrini血蜱、formosensis血蜱、hystricis血蜱和wellingtoni血蜱7种。牛和犬的蜱类分别以微头蜱和林奈头蜱为优势蜱种，水牛、鸡、鸭、鹅、猪和鸽子均未发现蜱类。结果表明，蜱虫在柬埔寨各地分布广泛，在森林边缘生境中尤其丰富。这项研究还使该国确定的蜱虫种类增加了7种，使总数达到26种。

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引用次数: 0

Ticks in changing times: Drought seems to be a main driver of declining Ixodes ricinus abundance in an urban setting 时代变化中的蜱虫：干旱似乎是城市环境中蓖麻蜱数量下降的主要原因

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102567

Orhan Bozbey, Andrea Springer, Anna-Katharina Topp, Antje Glass, Christina Strube

Urban green spaces promote human well-being, but also represent areas of tick infestation and pathogen transmission risk. In Hanover city, Germany, long-term monitoring of questing tick abundance was initiated in 2017–2018 (Hauck et al., 2020). Here, we combine this data with a six-year follow-up, including the 2018–2020 and 2022 Europe-wide drought periods. Additionally, the density of infected nymphs (DIN) was calculated including pathogen prevalence data from 2020 (Glass et al., 2022). Tick density was observed to decline after drought years with a time lag, falling from an average of 25 and 26 ticks per 100 m² in 2017 and 2018 to 20 ticks in 2019, 16 in 2020 and 6 in 2021, which is a reduction of almost 75%. After the precipitation-rich year of 2021, density began to recover in 2022 (7 ticks/100 m²), but remained low in 2023 (10 ticks/100 m²) and 2024 (8 ticks/100 m²). After the 8-year observation period, tick density has therefore been reduced by almost 70% compared to initial values. Generalized linear mixed modelling showed significant associations between I. ricinus density and climatic variables. The DIN per monitoring site was 0.03–9.76/100 m², 0.00–0.04/100 m² and 0.11–16.81/100 m² for Borrelia spp., A. phagocytophilum, and Rickettsia species. This study strongly indicates that climate change, especially prolonged drought, affects I. ricinus populations in urban settings, and its long-term dataset can serve as a reference for future ecological and public-health risk assessments under a changing climate.

城市绿地促进了人类福祉，但也代表了蜱虫侵扰和病原体传播风险的区域。在德国汉诺威市，2017-2018年开始了对蜱虫丰度的长期监测（Hauck et al., 2020）。在这里，我们将这些数据与六年的随访相结合，包括2018-2020年和2022年欧洲范围内的干旱期。此外，还计算了感染若虫的密度（DIN），包括2020年的病原体患病率数据（Glass et al., 2022）。在干旱年份之后，蜱虫密度出现了时滞性下降，从2017年和2018年的平均每100平方米25和26只蜱降至2019年的20只、2020年的16只和2021年的6只，减少了近75%。经过2021年的丰水年，密度在2022年开始回升（7只/100 m²），但在2023年（10只/100 m²）和2024年（8只/100 m²）仍处于低位。因此，经过8年观察期后，蜱虫密度与初始值相比减少了近70%。广义线性混合模型显示蓖麻密度与气候变量之间存在显著关联。每个监测点伯氏疏螺旋体、嗜吞噬单胞杆菌和立克次体的DIN分别为0.03 ~ 9.76/100 m²、0.00 ~ 0.04/100 m²和0.11 ~ 16.81/100 m²。该研究强烈表明，气候变化，特别是长期干旱，会影响城市环境中的蓖麻种群，其长期数据集可作为未来气候变化下生态和公共卫生风险评估的参考。

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引用次数: 0

Patterns of demographic and behavioral factors associated with tick encounters in Maine (USA) using passive surveillance data 使用被动监测数据分析美国缅因州蜱虫接触相关的人口统计和行为因素模式。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102573

Griffin M. Dill , Thomas F. Rounsville , Ann M. Bryant , Allison M. Gardner

While ecological factors drive tick abundance and pathogen prevalence, human behaviors and demographics can interact with these ecological drivers to shape tick encounter risk. We analyzed 7848 tick submissions and associated survey responses from Maine residents collected from January 2020 through December 2022 via a passive tick surveillance program. We examined the spatial and demographic differences in the use of tick prevention strategies among individuals who submitted tick specimens. We investigated differences in tick encounter frequency across reported property types and human activities and differences in tick attachment sites on the body, based upon human age and tick life stage. We found that personal protection measures were used prior to only 15 % of reported tick encounters, with higher usage reported for ticks found on adults than children and by individuals engaged in high-perceived-risk activities including camping, hunting, hiking, and agricultural work. We also detected spatial differences, with residents of southern regions that generally have higher acarological risk employing preventive measures more frequently than those in northern regions. Tick encounters were commonly reported at participants’ residences, often during yardwork/gardening and outdoor play. We noted age-related patterns in bite frequency and attachment sites, with children more frequently bitten on the head and neck and adults on the legs and torso. Across all age classes, immature ticks tended to attach lower on the body. By identifying high-risk areas, vulnerable age groups, predominant tick attachment sites, and gaps in protective practices, our findings can inform the development and implementation of targeted tick protection interventions.

虽然生态因素驱动蜱虫的丰度和病原体的流行，但人类的行为和人口统计学可以与这些生态驱动因素相互作用，形成蜱虫遭遇风险。我们分析了从2020年1月到2022年12月通过被动蜱虫监测计划收集的缅因州居民的7848份蜱虫意见书和相关调查回复。我们检查了提交蜱虫标本的个体在使用蜱虫预防策略方面的空间和人口差异。根据人类的年龄和蜱虫的生命阶段，我们调查了蜱虫接触频率在报告的财产类型和人类活动中的差异，以及蜱虫附着部位在身体上的差异。我们发现，在报告的蜱虫遭遇事件中，只有15%的人采取了个人保护措施，报告的蜱虫使用率高于儿童和从事高风险活动（包括露营、狩猎、徒步旅行和农业工作）的个人。我们还发现了空间差异，南方地区的居民通常比北方地区的居民更频繁地采取预防措施。蜱虫接触通常发生在参与者的住所，通常是在庭院/园艺和户外玩耍期间。我们注意到被咬的频率和附着部位与年龄有关，儿童更常被咬在头部和颈部，而成人更常被咬在腿部和躯干。在所有年龄段中，未成熟的蜱虫倾向于附着在身体的较低部位。通过确定高风险地区、脆弱年龄组、主要蜱虫附着地点和保护措施的差距，我们的研究结果可以为制定和实施有针对性的蜱虫保护干预措施提供信息。

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引用次数: 0

Prevalence of heartwater in Guadeloupe (2024): stable endemicity and evidence of spread to Les Saintes 瓜德罗普岛心水流行（2024年）：稳定的地方性流行和向Les Saintes传播的证据。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102569

Victor Dufleit , Laure Guerrini , Mélanie Dhune , Laetitia Viry , Armande Belfort , Loïc Jacquet-Crétides , Jimmy Deddy , Joanna Cozier , Michel Naves , Ludovic Arthein , Thony Samut , Sylvie Lecollinet , Manuel Pezeron , Valerie Rodrigues , Damien F Meyer , Eric M C Etter

Heartwater is a tick-borne disease caused by Ehrlichia ruminantium and remains endemic in the Guadeloupe archipelago. While previous data from 1989 suggested a seroprevalence of 22 % in cattle, no updated figures were available for livestock, and certain islands such as Les Saintes were considered disease-free.

This study aimed to update the sero-epidemiological status of heartwater in cattle and goats across Guadeloupe in 2024. Blood samples were collected from 261 cattle and 135 goats from all islands. Serological testing using the MAP1B ELISA was performed, and true seroprevalence was estimated using a simplified stochastic model that accounts for test sensitivity, specificity, and sample uncertainty. The mean cattle seroprevalence was estimated at 28 % (95 % CI [22–34 %]), with no significant differences between Basse-Terre, Grande-Terre, and Marie-Galante. Importantly, seropositive goats were identified on all major islands, including Les Saintes. Our findings suggest that heartwater remains endemically stable in Guadeloupe since the 1980s and reveal for the first time its serological presence in Les Saintes. These results emphasize the importance of strengthening regional surveillance systems, including veterinary reporting, serological monitoring, and coordinated efforts to prevent further spread across the Caribbean.

心水病是一种由反刍埃利希菌引起的蜱传疾病，在瓜德罗普群岛仍然流行。虽然1989年以前的数据表明牛的血清患病率为22%，但没有牲畜的最新数据，而且某些岛屿如Les Saintes被认为是无病的。本研究旨在更新2024年瓜德罗普岛牛和山羊心水的血清流行病学状况。从所有岛屿的261头牛和135头山羊中采集了血液样本。使用MAP1B ELISA进行血清学检测，并使用简化的随机模型估计真实血清阳性率，该模型考虑了检测敏感性、特异性和样本不确定性。牛的平均血清阳性率估计为28% (95% CI[22- 34%])，在Basse-Terre、Grande-Terre和Marie-Galante之间没有显著差异。重要的是，在包括Les Saintes岛在内的所有主要岛屿上都发现了血清阳性山羊。我们的研究结果表明，自20世纪80年代以来，心水在瓜德罗普岛保持地方性稳定，并首次揭示了其在Les Saintes的血清学存在。这些结果强调了加强区域监测系统的重要性，包括兽医报告、血清学监测和协调努力，以防止在加勒比地区进一步传播。

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引用次数: 0

Incidental infestations of humans by hard ticks (Acari: Ixodidae) in Colombia: Case reports and record of Amblyomma cajennense sensu stricto 哥伦比亚硬蜱（蜱螨：伊蚊科）对人类的偶发侵害：严格卡詹氏弱视虫病例报告和记录。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102565

Omar Esteban Vargas-Martínez , Luisa Fernanda Naranjo-Vargas , Laura Aramendiz-Macías , Francisco J. Díaz , Juan Carlos Quintero-Vélez , Thiago Fernandes Martins , Juan David Rodas-González

In Colombia, there are few studies that describe tick parasitism in humans, as well as its demographic and ecological characteristics. Additionally, multiple cases of human rickettsiosis caused by highly pathogenic Rickettsia species have been reported, whose vector remains unknown. This study reports new cases of human infestation by hard ticks in rural areas of different municipalities of Colombia between 2021 and 2023. The collected ticks were identified using taxonomic keys and molecular and phylogenetic analyses. Likewise, geographical data and other variables associated with parasitism were recorded. A total of 17 hard ticks were collected, associated with 15 infestation cases from nine individuals in eight municipalities across four departments of Colombia. Our findings included infestations by Amblyomma cajennense sensu stricto [s.s.] in the department of Meta, a species never reported in Colombia, and Amblyomma oblongoguttatum in Antioquia, not reported in humans since 1949. We also report cases of human parasitism by Amblyomma mixtum, Dermacentor nitens, and Rhipicephalus microplus. No Rickettsia bacteria were detected in the ticks. This study highlights the importance of recording the interaction of these ectoparasites with humans in Colombia, expanding knowledge about the diversity of tick species and their parasitic activity in our country.

在哥伦比亚，很少有研究描述蜱寄生在人类身上，以及它的人口和生态特征。此外，已报告了由高致病性立克次体物种引起的多例人类立克次体病，其媒介仍然未知。本研究报告了2021年至2023年期间哥伦比亚不同城市农村地区硬蜱感染人类的新病例。收集到的蜱虫通过分类键、分子和系统发育分析进行鉴定。同样，还记录了地理数据和其他与寄生有关的变量。共收集到17只硬蜱，与来自哥伦比亚4个省8个城市9个人的15例感染病例有关。我们的发现包括卡延氏狭义弱视瘤（Amblyomma cajenense sensu stricto）的侵染。]，这是一种在哥伦比亚从未报道过的物种，以及安蒂奥基亚的长形双足虫，自1949年以来没有在人类身上报道过。我们也报告了混合弱视虫、黑皮肤螨和微型鼻头虫的病例。蜱中未检出立克次体细菌。这项研究强调了在哥伦比亚记录这些体外寄生虫与人类相互作用的重要性，扩大了对我国蜱类物种多样性及其寄生活动的认识。

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引用次数: 0

UB-221, an antibody that neutralizes IgE and downregulates the CD23 receptor: a potential treatment for the alpha-gal syndrome UB-221，一种中和IgE并下调CD23受体的抗体：一种治疗α -半乳糖综合征的潜在方法。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102562

Sandra E. Reznik , Amit K. Tiwari , Charles R. Ashby Jr.

引用次数: 0

Tick responses to diverse chemical attractants to enhance tick surveillance methods’ efficacy 蜱对不同化学引诱剂的反应，提高蜱监测方法的有效性

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102577

Pamela Kelman , Tyler Chavers , Emily Owens Pickle , Daniel Sonenshine , Melissa S Nolan , Holly Gaff

Amblyomma maculatum Koch (Acari: Ixodidae), Ixodes scapularis Say, and Dermacentor variabilis Say are three hard-bodied ticks responsible for vectoring pathogens that cause most human tick-borne diseases in the United States of America (USA). Tick surveillance is critical to elucidate high-risk areas for targeted vector control and public health interventions. Despite tick-borne diseases having a higher annual incidence compared to mosquito-borne diseases in the USA, tick traps used for surveillance are grossly under-developed compared to the suite of sophisticated mosquito traps available on the commercial market. This study sought to identify potential prospective tick trap improvements by evaluating the relative attraction of three medically important tick species to odor attractants in a laboratory setting: carbon dioxide, ammonia, deer musk, and rodent musk. This study found that carbon dioxide gas and rodent musk had limited attraction to all three tick species and across life stages. Conversely, this study did find that deer musk and ammonia demonstrated favorable attraction for I. scapularis and D. variabilis across multiple life stages, suggesting standard tick trap techniques might be improved using low-cost and practical alternate attractants. Future field-based studies of these odor attractants, both singularly and in combination with the standard dry ice, are warranted to evaluate potential increased efficacy for broad tick species vector surveillance methods.

斑点无眼蜱（蜱螨目：硬蜱科）、肩胛骨硬蜱和变皮蜱是三种硬体蜱，负责传播导致美国大多数人类蜱媒疾病的病原体。蜱虫监测对于阐明有针对性的媒介控制和公共卫生干预的高风险地区至关重要。尽管在美国，蜱传疾病的年发病率高于蚊传疾病，但与商业市场上可获得的一套复杂的蚊子陷阱相比，用于监测的蜱虫陷阱严重欠发达。本研究试图通过在实验室环境中评估三种医学上重要的蜱类对气味引诱剂的相对吸引力，即二氧化碳、氨、鹿麝香和啮齿动物麝香，来确定潜在的潜在蜱虫诱捕器的改进。这项研究发现，二氧化碳气体和啮齿动物麝香对所有三种蜱虫的吸引力有限，而且在生命的各个阶段都是如此。相反，本研究确实发现，鹿麝香和氨水在多个生命阶段对肩胛骨夜蛾和变异夜蛾具有良好的吸引力，这表明使用低成本和实用的替代引诱剂可以改进标准的蜱虫诱捕技术。未来对这些气味引诱剂的实地研究，无论是单独使用还是与标准干冰结合使用，都有必要评估广泛蜱虫媒介监测方法可能增加的效果。

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引用次数: 0

Corrigendum to “First molecular detection of Anaplasma marginale, Babesia bovis, and hemotropic Mycoplasma spp. in bovine colostrum” [Ticks and Tick-borne Diseases 16 (2025) 102553] “牛初乳中边缘无原体、牛巴贝斯虫和嗜血支原体的首次分子检测”[蜱和蜱传疾病16(2025)102553]的勘误表。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102564

Mayara Campos Lombardi , Nicolas Colacio , Camila de Valgas e Bastos , Sandra Gesteira Coelho , Tiago Facury Moreira , Rodrigo Melo Meneses , Antônio Último de Carvalho , Elias Jorge Facury-Filho , Júlia Angelica Gonçalves Silveira

引用次数: 0

Corrigendum to “Various small mammal hosts are involved in the transmission cycle of zoonotic Anaplasma phagocytophilum in Southeastern Canada” [Ticks and Tick-borne Diseases (2025) Volume 16, Issue 6] “各种小型哺乳动物宿主参与加拿大东南部人畜共患病嗜吞噬细胞无原体的传播周期”[蜱和蜱传疾病（2025）第16卷，第6期]的更正。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102563

Raphaëlle Audet-Legault , Cécile Aenishaenslin , Geneviève Baron , Heather Coatsworth , Marion Desmarchelier , Vanessa Gabriele-Rivet , Patrick A․ Leighton , Jérôme Pelletier , Jean-Philippe Rocheleau , Catherine Bouchard

引用次数: 0

Quantitative proteomic analysis of salivary glands in female Ornithodoros lahorensis (syn. Alveonasus lahorensis) after blood feeding via DIA-coupled LC-MS/MS 利用双级联LC-MS/MS对雌性拉霍伦鸟（Ornithodoros lahorensis，同音：Alveonasus lahorensis）供血后唾液腺的定量蛋白质组学分析

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102575

Xiangfen Yuan , Xiaolin Xu , Huiyu Wang , Hongli Jing , Songyin Qiu , Yufang Kong , Yue Zhang , Jizhou Lv , Xun Suo , Shaoqiang Wu

Ornithodoros lahorensis (syn. Alveonasus lahorensis) is a species of soft tick within the Argasidae family, known for causing debilitating symptoms, as well as transmitting pathogens that pose significant health risks and economic losses to affected livestock and potentially humans. The salivary gland is the key component in the pathogenic mechanisms of ticks, as it not only facilitates feeding but also serves as a medium for pathogen transmission. Here, data-independent acquisition (DIA) coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to quantitatively identify differentially expressed proteins (DEPs) in female O. lahorensis salivary glands after blood feeding. A total of 3866 proteins were annotated, and 1185 DEPs were identified at 24 h post-feeding (1105 upregulated, 80 downregulated). The data are available via ProteomeXchange with identifier PXD059319. Bioinformatics analyses revealed that these DEPs are primarily involved in metabolic processes, immune regulation, ribosomal assembly, and signal transduction. This study provides the first comprehensive analysis of the O. lahorensis salivary glands proteomes during the early post-feeding period, offering valuable insights for future research on and control ticks and tick-borne diseases.

lahorensis（同：Alveonasus lahorensis）是一种软蜱，属于松毛虫科，以引起衰弱症状和传播病原体而闻名，对受影响的牲畜和潜在的人类造成重大健康风险和经济损失。唾液腺是蜱的致病机制的关键组成部分，因为它不仅促进了摄食，而且是病原体传播的媒介。本研究采用数据独立采集（DIA）与液相色谱-串联质谱（LC-MS/MS）相结合的方法，定量鉴定了吸血后雌拉荷莲唾液腺中的差异表达蛋白（DEPs）。共注释了3866个蛋白，在喂食后24 h鉴定出1185个dep（1105个上调，80个下调）。数据可通过ProteomeXchange获得，标识符为PXD059319。生物信息学分析显示，这些dep主要参与代谢过程、免疫调节、核糖体组装和信号转导。本研究首次全面分析了吸血后早期lahorensis的唾液腺蛋白质组，为今后研究和控制蜱和蜱传疾病提供了有价值的见解。

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引用次数: 0