Ticks and Tick-borne Diseases最新文献_第7页

Comparison of the number of Lyme neuroborreliosis cases in European Centre for Disease Prevention and Control (ECDC) data and national public surveillance reports, 2018–2023 2018-2023年欧洲疾病预防控制中心（ECDC）数据和国家公共监测报告中莱姆病神经螺旋体病病例数的比较

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-09-19 DOI: 10.1016/j.ttbdis.2025.102542

Alexander Davidson , Frederick J. Angulo , Julie Davis , Kate Halsby , Gordon Brestrich , Jennifer C. Moïsi , James H. Stark

Lyme borreliosis (LB) is the most common vector-borne disease in Europe. At least 29 European Economic Area (EEA) countries publish online LB surveillance reports. However, countries have different criteria for what is notifiable for LB surveillance, limiting comparability. EEA countries began reporting Lyme neuroborreliosis (LNB) cases, a disseminated LB manifestation, to the European Centre for Disease Prevention and Control (ECDC) in 2018, using a uniform case definition. This analysis compared LNB data from ECDC and national surveillance reports to evaluate their utility in monitoring LB in Europe. LNB surveillance data from 2018 to 2023 were downloaded from ECDC. Nationally reported online LB surveillance data from EEA countries were identified and reviewed. Countries that reported LNB cases in national surveillance and to ECDC were included and case data were compared. Of 31 EEA countries during 2018 to 2023, 11 (35 %) differentiated LNB cases in their national published LB surveillance; eight of these also reported to ECDC. The number of LNB cases published in national reports in these eight countries did not exactly match the number of LNB cases reported to ECDC but overall disease trends were similar. Comparing the LNB cases from eight countries in ECDC and national surveillance demonstrates that both capture evolving LNB disease trends despite some differences in the number of cases reported to each. To allow for more robust comparisons of LB burden and trends across Europe, harmonizing case definitions and reporting mechanisms for LB would provide great value.

莱姆病（LB）是欧洲最常见的媒介传播疾病。至少有29个欧洲经济区（EEA）国家发布在线LB监测报告。然而，各国对LB监测应通报的内容有不同的标准，限制了可比性。欧洲经济区国家于2018年开始使用统一的病例定义向欧洲疾病预防和控制中心（ECDC）报告莱姆病神经螺旋体病（LNB）病例，这是一种播散性LB表现。该分析比较了ECDC的LNB数据和国家监测报告，以评估其在欧洲监测LB的效用。2018 - 2023年LNB监测数据下载自ECDC。确定并审查了欧洲经济区国家报告的全国在线LB监测数据。纳入了在国家监测中报告LNB病例的国家和向ECDC报告LNB病例的国家，并比较了病例数据。在2018年至2023年期间，31个欧洲经济区国家中，11个（35%）在其国家公布的LB监测中区分了LNB病例；其中8家也向ECDC报告。在这8个国家的国家报告中公布的LNB病例数与向ECDC报告的LNB病例数并不完全匹配，但总体疾病趋势相似。比较八个国家在ECDC和国家监测方面的LNB病例表明，尽管各自报告的病例数存在一些差异，但两者都捕捉到了LNB疾病的发展趋势。为了对整个欧洲的LB负担和趋势进行更有力的比较，统一LB的病例定义和报告机制将具有很大的价值。

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引用次数: 0

Ticks in changing times: Drought seems to be a main driver of declining Ixodes ricinus abundance in an urban setting 时代变化中的蜱虫：干旱似乎是城市环境中蓖麻蜱数量下降的主要原因

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-11-14 DOI: 10.1016/j.ttbdis.2025.102567

Orhan Bozbey, Andrea Springer, Anna-Katharina Topp, Antje Glass, Christina Strube

Urban green spaces promote human well-being, but also represent areas of tick infestation and pathogen transmission risk. In Hanover city, Germany, long-term monitoring of questing tick abundance was initiated in 2017–2018 (Hauck et al., 2020). Here, we combine this data with a six-year follow-up, including the 2018–2020 and 2022 Europe-wide drought periods. Additionally, the density of infected nymphs (DIN) was calculated including pathogen prevalence data from 2020 (Glass et al., 2022). Tick density was observed to decline after drought years with a time lag, falling from an average of 25 and 26 ticks per 100 m² in 2017 and 2018 to 20 ticks in 2019, 16 in 2020 and 6 in 2021, which is a reduction of almost 75%. After the precipitation-rich year of 2021, density began to recover in 2022 (7 ticks/100 m²), but remained low in 2023 (10 ticks/100 m²) and 2024 (8 ticks/100 m²). After the 8-year observation period, tick density has therefore been reduced by almost 70% compared to initial values. Generalized linear mixed modelling showed significant associations between I. ricinus density and climatic variables. The DIN per monitoring site was 0.03–9.76/100 m², 0.00–0.04/100 m² and 0.11–16.81/100 m² for Borrelia spp., A. phagocytophilum, and Rickettsia species. This study strongly indicates that climate change, especially prolonged drought, affects I. ricinus populations in urban settings, and its long-term dataset can serve as a reference for future ecological and public-health risk assessments under a changing climate.

城市绿地促进了人类福祉，但也代表了蜱虫侵扰和病原体传播风险的区域。在德国汉诺威市，2017-2018年开始了对蜱虫丰度的长期监测（Hauck et al., 2020）。在这里，我们将这些数据与六年的随访相结合，包括2018-2020年和2022年欧洲范围内的干旱期。此外，还计算了感染若虫的密度（DIN），包括2020年的病原体患病率数据（Glass et al., 2022）。在干旱年份之后，蜱虫密度出现了时滞性下降，从2017年和2018年的平均每100平方米25和26只蜱降至2019年的20只、2020年的16只和2021年的6只，减少了近75%。经过2021年的丰水年，密度在2022年开始回升（7只/100 m²），但在2023年（10只/100 m²）和2024年（8只/100 m²）仍处于低位。因此，经过8年观察期后，蜱虫密度与初始值相比减少了近70%。广义线性混合模型显示蓖麻密度与气候变量之间存在显著关联。每个监测点伯氏疏螺旋体、嗜吞噬单胞杆菌和立克次体的DIN分别为0.03 ~ 9.76/100 m²、0.00 ~ 0.04/100 m²和0.11 ~ 16.81/100 m²。该研究强烈表明，气候变化，特别是长期干旱，会影响城市环境中的蓖麻种群，其长期数据集可作为未来气候变化下生态和公共卫生风险评估的参考。

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引用次数: 0

Prevalence of heartwater in Guadeloupe (2024): stable endemicity and evidence of spread to Les Saintes 瓜德罗普岛心水流行（2024年）：稳定的地方性流行和向Les Saintes传播的证据。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-11-16 DOI: 10.1016/j.ttbdis.2025.102569

Victor Dufleit , Laure Guerrini , Mélanie Dhune , Laetitia Viry , Armande Belfort , Loïc Jacquet-Crétides , Jimmy Deddy , Joanna Cozier , Michel Naves , Ludovic Arthein , Thony Samut , Sylvie Lecollinet , Manuel Pezeron , Valerie Rodrigues , Damien F Meyer , Eric M C Etter

Heartwater is a tick-borne disease caused by Ehrlichia ruminantium and remains endemic in the Guadeloupe archipelago. While previous data from 1989 suggested a seroprevalence of 22 % in cattle, no updated figures were available for livestock, and certain islands such as Les Saintes were considered disease-free.

This study aimed to update the sero-epidemiological status of heartwater in cattle and goats across Guadeloupe in 2024. Blood samples were collected from 261 cattle and 135 goats from all islands. Serological testing using the MAP1B ELISA was performed, and true seroprevalence was estimated using a simplified stochastic model that accounts for test sensitivity, specificity, and sample uncertainty. The mean cattle seroprevalence was estimated at 28 % (95 % CI [22–34 %]), with no significant differences between Basse-Terre, Grande-Terre, and Marie-Galante. Importantly, seropositive goats were identified on all major islands, including Les Saintes. Our findings suggest that heartwater remains endemically stable in Guadeloupe since the 1980s and reveal for the first time its serological presence in Les Saintes. These results emphasize the importance of strengthening regional surveillance systems, including veterinary reporting, serological monitoring, and coordinated efforts to prevent further spread across the Caribbean.

心水病是一种由反刍埃利希菌引起的蜱传疾病，在瓜德罗普群岛仍然流行。虽然1989年以前的数据表明牛的血清患病率为22%，但没有牲畜的最新数据，而且某些岛屿如Les Saintes被认为是无病的。本研究旨在更新2024年瓜德罗普岛牛和山羊心水的血清流行病学状况。从所有岛屿的261头牛和135头山羊中采集了血液样本。使用MAP1B ELISA进行血清学检测，并使用简化的随机模型估计真实血清阳性率，该模型考虑了检测敏感性、特异性和样本不确定性。牛的平均血清阳性率估计为28% (95% CI[22- 34%])，在Basse-Terre、Grande-Terre和Marie-Galante之间没有显著差异。重要的是，在包括Les Saintes岛在内的所有主要岛屿上都发现了血清阳性山羊。我们的研究结果表明，自20世纪80年代以来，心水在瓜德罗普岛保持地方性稳定，并首次揭示了其在Les Saintes的血清学存在。这些结果强调了加强区域监测系统的重要性，包括兽医报告、血清学监测和协调努力，以防止在加勒比地区进一步传播。

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引用次数: 0

UB-221, an antibody that neutralizes IgE and downregulates the CD23 receptor: a potential treatment for the alpha-gal syndrome UB-221，一种中和IgE并下调CD23受体的抗体：一种治疗α -半乳糖综合征的潜在方法。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-10-29 DOI: 10.1016/j.ttbdis.2025.102562

Sandra E. Reznik , Amit K. Tiwari , Charles R. Ashby Jr.

引用次数: 0

Incidental infestations of humans by hard ticks (Acari: Ixodidae) in Colombia: Case reports and record of Amblyomma cajennense sensu stricto 哥伦比亚硬蜱（蜱螨：伊蚊科）对人类的偶发侵害：严格卡詹氏弱视虫病例报告和记录。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-11-13 DOI: 10.1016/j.ttbdis.2025.102565

Omar Esteban Vargas-Martínez , Luisa Fernanda Naranjo-Vargas , Laura Aramendiz-Macías , Francisco J. Díaz , Juan Carlos Quintero-Vélez , Thiago Fernandes Martins , Juan David Rodas-González

In Colombia, there are few studies that describe tick parasitism in humans, as well as its demographic and ecological characteristics. Additionally, multiple cases of human rickettsiosis caused by highly pathogenic Rickettsia species have been reported, whose vector remains unknown. This study reports new cases of human infestation by hard ticks in rural areas of different municipalities of Colombia between 2021 and 2023. The collected ticks were identified using taxonomic keys and molecular and phylogenetic analyses. Likewise, geographical data and other variables associated with parasitism were recorded. A total of 17 hard ticks were collected, associated with 15 infestation cases from nine individuals in eight municipalities across four departments of Colombia. Our findings included infestations by Amblyomma cajennense sensu stricto [s.s.] in the department of Meta, a species never reported in Colombia, and Amblyomma oblongoguttatum in Antioquia, not reported in humans since 1949. We also report cases of human parasitism by Amblyomma mixtum, Dermacentor nitens, and Rhipicephalus microplus. No Rickettsia bacteria were detected in the ticks. This study highlights the importance of recording the interaction of these ectoparasites with humans in Colombia, expanding knowledge about the diversity of tick species and their parasitic activity in our country.

在哥伦比亚，很少有研究描述蜱寄生在人类身上，以及它的人口和生态特征。此外，已报告了由高致病性立克次体物种引起的多例人类立克次体病，其媒介仍然未知。本研究报告了2021年至2023年期间哥伦比亚不同城市农村地区硬蜱感染人类的新病例。收集到的蜱虫通过分类键、分子和系统发育分析进行鉴定。同样，还记录了地理数据和其他与寄生有关的变量。共收集到17只硬蜱，与来自哥伦比亚4个省8个城市9个人的15例感染病例有关。我们的发现包括卡延氏狭义弱视瘤（Amblyomma cajenense sensu stricto）的侵染。]，这是一种在哥伦比亚从未报道过的物种，以及安蒂奥基亚的长形双足虫，自1949年以来没有在人类身上报道过。我们也报告了混合弱视虫、黑皮肤螨和微型鼻头虫的病例。蜱中未检出立克次体细菌。这项研究强调了在哥伦比亚记录这些体外寄生虫与人类相互作用的重要性，扩大了对我国蜱类物种多样性及其寄生活动的认识。

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引用次数: 0

Tick responses to diverse chemical attractants to enhance tick surveillance methods’ efficacy 蜱对不同化学引诱剂的反应，提高蜱监测方法的有效性

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-12-06 DOI: 10.1016/j.ttbdis.2025.102577

Pamela Kelman , Tyler Chavers , Emily Owens Pickle , Daniel Sonenshine , Melissa S Nolan , Holly Gaff

Amblyomma maculatum Koch (Acari: Ixodidae), Ixodes scapularis Say, and Dermacentor variabilis Say are three hard-bodied ticks responsible for vectoring pathogens that cause most human tick-borne diseases in the United States of America (USA). Tick surveillance is critical to elucidate high-risk areas for targeted vector control and public health interventions. Despite tick-borne diseases having a higher annual incidence compared to mosquito-borne diseases in the USA, tick traps used for surveillance are grossly under-developed compared to the suite of sophisticated mosquito traps available on the commercial market. This study sought to identify potential prospective tick trap improvements by evaluating the relative attraction of three medically important tick species to odor attractants in a laboratory setting: carbon dioxide, ammonia, deer musk, and rodent musk. This study found that carbon dioxide gas and rodent musk had limited attraction to all three tick species and across life stages. Conversely, this study did find that deer musk and ammonia demonstrated favorable attraction for I. scapularis and D. variabilis across multiple life stages, suggesting standard tick trap techniques might be improved using low-cost and practical alternate attractants. Future field-based studies of these odor attractants, both singularly and in combination with the standard dry ice, are warranted to evaluate potential increased efficacy for broad tick species vector surveillance methods.

斑点无眼蜱（蜱螨目：硬蜱科）、肩胛骨硬蜱和变皮蜱是三种硬体蜱，负责传播导致美国大多数人类蜱媒疾病的病原体。蜱虫监测对于阐明有针对性的媒介控制和公共卫生干预的高风险地区至关重要。尽管在美国，蜱传疾病的年发病率高于蚊传疾病，但与商业市场上可获得的一套复杂的蚊子陷阱相比，用于监测的蜱虫陷阱严重欠发达。本研究试图通过在实验室环境中评估三种医学上重要的蜱类对气味引诱剂的相对吸引力，即二氧化碳、氨、鹿麝香和啮齿动物麝香，来确定潜在的潜在蜱虫诱捕器的改进。这项研究发现，二氧化碳气体和啮齿动物麝香对所有三种蜱虫的吸引力有限，而且在生命的各个阶段都是如此。相反，本研究确实发现，鹿麝香和氨水在多个生命阶段对肩胛骨夜蛾和变异夜蛾具有良好的吸引力，这表明使用低成本和实用的替代引诱剂可以改进标准的蜱虫诱捕技术。未来对这些气味引诱剂的实地研究，无论是单独使用还是与标准干冰结合使用，都有必要评估广泛蜱虫媒介监测方法可能增加的效果。

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引用次数: 0

Ferritin-mediated regulation of gut microbiota homeostasis promotes blood-feeding adaptation in the tick Haemaphysalis doenitzi 铁蛋白介导的肠道微生物群稳态调节促进蜱血蜱的吸血适应。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-09-30 DOI: 10.1016/j.ttbdis.2025.102554

Zhihua Gao , Xiaofeng Xu , Yanqing Shi , Jiayi Zhang, Weijia Xing, Xinyu Zhang, Weikang Zhao, Ruya Cao, Xiaolong Yang

As obligate hematophagous parasites, ticks have evolved to cope with substantial amounts of iron and exogenous microorganisms present in host blood during feeding. In ticks, ferritin plays an important role in maintaining the oxidative balance of gut and the homeostasis of the microbial community structure, but its regulatory mechanism has not yet been clarified. This study successfully identified a ferritin gene from Haemaphysalis doenitzi, named Hd-fer, and further studied the function of Hd-fer. The results showed that rHd-fer had antioxidant properties and antibacterial activity. The expression of Hd-fer gene in the ovary and midgut was significantly higher than other organs, and the expression in adults was significantly higher than other stages. The Hd-fer gene knock-out significantly changed the abundance of the midgut microbial community, and the relative abundance decreased generally, while the relative abundance of Achromobacter increased. The knockout of Hd-fer gene also significantly changed the structural composition of the midgut microbial species, and pathogenic microorganisms showed a growing trend, producing their unique microbial genera, including Barnesiellaceae, Carnobacterium and Pediococcus. The RNA interference of Hd-fer led to prolonging the tick's blood sucking time and reducing engorged weight. The results of this study showed that Hd-fer may affect the stability of the midgut microbial community structure by regulating iron availability, which in turn plays an important role in the survival and reproduction of ticks. These findings provide novel insights into the role of ferritin in tick biology and highlight its potential as a target for controlling tick-borne diseases.

作为专性食血寄生虫，蜱虫已经进化到能够应对宿主血液中大量的铁和外源微生物。在蜱中，铁蛋白在维持肠道氧化平衡和微生物群落结构的稳态中起着重要作用，但其调控机制尚不清楚。本研究成功地从多尼茨血蜱中鉴定出一个铁蛋白基因，命名为Hd-fer，并进一步研究了Hd-fer的功能。结果表明，黄芪多糖具有抗氧化和抑菌活性。Hd-fer基因在卵巢和中肠的表达量显著高于其他脏器，在成虫中的表达量显著高于其他脏器。Hd-fer基因敲除显著改变了中肠微生物群落的丰度，其相对丰度普遍降低，而无色杆菌的相对丰度升高。Hd-fer基因的敲除也显著改变了中肠微生物种类的结构组成，致病微生物呈增长趋势，产生了其独特的微生物属，包括Barnesiellaceae、Carnobacterium和Pediococcus。Hd-fer的RNA干扰导致蜱虫吸血时间延长，充血体重减轻。本研究结果表明，Hd-fer可能通过调节铁的有效性来影响中肠微生物群落结构的稳定性，从而在蜱的生存和繁殖中发挥重要作用。这些发现为铁蛋白在蜱生物学中的作用提供了新的见解，并突出了它作为控制蜱传疾病的靶点的潜力。

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引用次数: 0

Corrigendum to “First molecular detection of Anaplasma marginale, Babesia bovis, and hemotropic Mycoplasma spp. in bovine colostrum” [Ticks and Tick-borne Diseases 16 (2025) 102553] “牛初乳中边缘无原体、牛巴贝斯虫和嗜血支原体的首次分子检测”[蜱和蜱传疾病16(2025)102553]的勘误表。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-11-07 DOI: 10.1016/j.ttbdis.2025.102564

Mayara Campos Lombardi , Nicolas Colacio , Camila de Valgas e Bastos , Sandra Gesteira Coelho , Tiago Facury Moreira , Rodrigo Melo Meneses , Antônio Último de Carvalho , Elias Jorge Facury-Filho , Júlia Angelica Gonçalves Silveira

引用次数: 0

Corrigendum to “Various small mammal hosts are involved in the transmission cycle of zoonotic Anaplasma phagocytophilum in Southeastern Canada” [Ticks and Tick-borne Diseases (2025) Volume 16, Issue 6] “各种小型哺乳动物宿主参与加拿大东南部人畜共患病嗜吞噬细胞无原体的传播周期”[蜱和蜱传疾病（2025）第16卷，第6期]的更正。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-10-30 DOI: 10.1016/j.ttbdis.2025.102563

Raphaëlle Audet-Legault , Cécile Aenishaenslin , Geneviève Baron , Heather Coatsworth , Marion Desmarchelier , Vanessa Gabriele-Rivet , Patrick A․ Leighton , Jérôme Pelletier , Jean-Philippe Rocheleau , Catherine Bouchard

引用次数: 0

Quantitative proteomic analysis of salivary glands in female Ornithodoros lahorensis (syn. Alveonasus lahorensis) after blood feeding via DIA-coupled LC-MS/MS 利用双级联LC-MS/MS对雌性拉霍伦鸟（Ornithodoros lahorensis，同音：Alveonasus lahorensis）供血后唾液腺的定量蛋白质组学分析

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 Epub Date: 2025-12-01 DOI: 10.1016/j.ttbdis.2025.102575

Xiangfen Yuan , Xiaolin Xu , Huiyu Wang , Hongli Jing , Songyin Qiu , Yufang Kong , Yue Zhang , Jizhou Lv , Xun Suo , Shaoqiang Wu

Ornithodoros lahorensis (syn. Alveonasus lahorensis) is a species of soft tick within the Argasidae family, known for causing debilitating symptoms, as well as transmitting pathogens that pose significant health risks and economic losses to affected livestock and potentially humans. The salivary gland is the key component in the pathogenic mechanisms of ticks, as it not only facilitates feeding but also serves as a medium for pathogen transmission. Here, data-independent acquisition (DIA) coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to quantitatively identify differentially expressed proteins (DEPs) in female O. lahorensis salivary glands after blood feeding. A total of 3866 proteins were annotated, and 1185 DEPs were identified at 24 h post-feeding (1105 upregulated, 80 downregulated). The data are available via ProteomeXchange with identifier PXD059319. Bioinformatics analyses revealed that these DEPs are primarily involved in metabolic processes, immune regulation, ribosomal assembly, and signal transduction. This study provides the first comprehensive analysis of the O. lahorensis salivary glands proteomes during the early post-feeding period, offering valuable insights for future research on and control ticks and tick-borne diseases.

lahorensis（同：Alveonasus lahorensis）是一种软蜱，属于松毛虫科，以引起衰弱症状和传播病原体而闻名，对受影响的牲畜和潜在的人类造成重大健康风险和经济损失。唾液腺是蜱的致病机制的关键组成部分，因为它不仅促进了摄食，而且是病原体传播的媒介。本研究采用数据独立采集（DIA）与液相色谱-串联质谱（LC-MS/MS）相结合的方法，定量鉴定了吸血后雌拉荷莲唾液腺中的差异表达蛋白（DEPs）。共注释了3866个蛋白，在喂食后24 h鉴定出1185个dep（1105个上调，80个下调）。数据可通过ProteomeXchange获得，标识符为PXD059319。生物信息学分析显示，这些dep主要参与代谢过程、免疫调节、核糖体组装和信号转导。本研究首次全面分析了吸血后早期lahorensis的唾液腺蛋白质组，为今后研究和控制蜱和蜱传疾病提供了有价值的见解。

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引用次数: 0