Ticks and Tick-borne Diseases最新文献

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Spotted fever group Rickettsia in Haemaphysalis ticks: genetic diversity and first detection of “Candidatus Rickettsia jingxinensis” in India 蜱血蜱斑疹热群立克次体：遗传多样性和印度首次检测到“京新立克次体候选菌”。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-12-11 DOI: 10.1016/j.ttbdis.2025.102580

Vinayak V , R. Balasubramanian , Siba S , Jayashri Patil , Pradnya Bhadale , Harsuni H , Sithalakshmi S , Jerlyn Varghese , Kalichamy Alagarasu

Ticks are important vectors of rickettsial pathogens, particularly in regions where livestock, wildlife, and humans overlap. Despite increasing reports of rickettsioses in India, molecular evidence of Rickettsia species in questing ticks from the Western Ghats of Kerala remains scarce. Questing ticks were collected from forest-edge and fringe habitats in Wayanad, Idukki, and Thrissur districts using standardized dragging. Species were identified morphologically, pooled, and screened for Rickettsia DNA by PCR targeting gltA and ompA genes. Amplicons were sequenced, and phylogenetic analysis was performed using reference sequences. Among 237 ticks belonging to six species, 24 % (12/50 pools) were PCR-positive for Rickettsia. The highest prevalence was observed in Haemaphysalis spinigera (50 %), followed by Haemaphysalis bispinosa (30 %) and Haemaphysalis turturis (9.5 %). Sequence analysis revealed the presence of Rickettsia massiliae and Rickettsia vini like species. Importantly, sequences closely related to “Candidatus Rickettsia jingxinensis” were detected for the first time in India, in H. turturis. Several isolates showed genetic divergence from known strains, suggesting the circulation of uncharacterized Rickettsia species or strains in tick population. This study provides the first molecular evidence of “Ca. R. jingxinensis” in H. turturis from India and demonstrates a high prevalence of Rickettsia spp. in questing ticks of Kerala. Given the pathogenic potential of some of these species, enhanced surveillance and incorporation of rickettsioses into differential diagnoses of febrile illnesses are needed in South India.

蜱是立克次体病原体的重要媒介，特别是在牲畜、野生动物和人类重叠的地区。尽管印度关于立克次体病的报道越来越多，但在喀拉拉邦西高止山脉的蜱虫中，立克次体物种的分子证据仍然很少。采用标准化拖拽方法从Wayanad、Idukki和Thrissur地区的森林边缘和边缘生境中收集蜱虫。采用gltA和ompA基因为靶点的PCR方法对立克次体DNA进行了形态学鉴定、汇总和筛选。扩增子测序，并使用参考序列进行系统发育分析。6种237只蜱中，立克次体pcr阳性占24%（12/50池）。发病率最高的是棘血蜱（50%），其次是双皮血蜱（30%）和turturis血蜱（9.5%）。序列分析显示存在马氏立克次体和类似立克次体的种。重要的是，在印度的H. turturis中首次检测到与“Candidatus立克次体jingxinensis”密切相关的序列。一些分离株显示出与已知菌株的遗传差异，提示在蜱种群中存在非特征立克次体种或菌株的循环。本研究首次提供了印度土氏蜱中存在“京新氏蜱”的分子证据，并证实了喀拉拉邦蜱中立克次体的高流行率。鉴于其中一些物种具有致病潜力，南印度需要加强监测并将立克次体病纳入发热性疾病的鉴别诊断。

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引用次数: 0

Propagation of Encephalitozoon cuniculi in tick cell lines supports the plausibility of possible tick-mediated transmission of this microsporidian 在蜱细胞系中的传播支持了这种微孢子虫可能通过蜱媒介传播的可能性

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-12-08 DOI: 10.1016/j.ttbdis.2025.102578

Bohumil Sak , Michaela Fibigerová , Kristína Mravcová , Nikola Holubová , Silvie Šikutová , Jana Fenclová , Lesley Bell-Sakyi , Martin Kváč , Ivo Rudolf

Microsporidia, obligate intracellular parasitic fungi, are increasingly associated with asymptomatic infections. One of the most prevalent zoonotic species, Encephalitozoon cuniculi, has been detected in Ixodes ricinus ticks. Nevertheless, the capacity of microsporidia to replicate within tick hosts remains unresolved. We used tick cell lines IRE11, IRE/CTVM19 and IRE/CTVM20 along with mammalian line Vero E6 for in vitro testing of E. cuniculi propagation. We evaluated the spore number using quantitative RT-PCR and documented the presence of microsporidia in host cells microscopically. We reported successful growth of Encephalitozoon cuniculi in tested tick cell lines, with IRE/CTVM19 providing the most suitable conditions for E. cuniculi propagation, reaching up to 1459 % increase of the inoculum. Moreover, the parasitophorous vacuoles containing developmental stages of microsporidia were observed in all cell lines. Our data support the plausibility of tick-mediated transmission, providing novel insights into the epidemiology of microsporidia.

微孢子虫，专性细胞内寄生真菌，越来越多地与无症状感染相关。其中最普遍的人畜共患病种之一，脑囊虫，已被发现在蓖麻蜱。然而，微孢子虫在蜱宿主体内复制的能力仍未得到解决。我们使用蜱细胞系IRE11、IRE/CTVM19和IRE/CTVM20与哺乳动物细胞系Vero E6进行了体外测试。我们使用定量RT-PCR评估孢子数量，并在显微镜下记录了宿主细胞中微孢子虫的存在。我们报道了蜱虫脑囊虫在蜱虫细胞株中成功生长，IRE/CTVM19为蜱虫的繁殖提供了最适宜的条件，接种量可达1459%。此外，在所有细胞系中都观察到含有小孢子虫发育阶段的寄生液泡。我们的数据支持蜱媒介传播的合理性，为微孢子虫的流行病学提供了新的见解。

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引用次数: 0

Trends in incidence of tick bites and physician-reported early and late Lyme borreliosis in the Netherlands 荷兰蜱虫叮咬和医生报告的早期和晚期莱姆病发病率趋势

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102561

Oda E. van den Berg, Margriet G. Harms, Anna D. Tulen, Vanessa D. Brown, Jan van de Kassteele, Agnetha Hofhuis, Cees C. van den Wijngaard

Lyme borreliosis (LB) is a prevalent vector-borne disease in Europe. Untreated, it can cause severe complications, with some patients experiencing persistent symptoms post-treatment. In the Netherlands, tick bite consultations and erythema migrans (EM) diagnoses tripled from 1994 to 2009, but tick bite consultations declined and EM diagnoses stabilized in 2014. This study examines trends in tick bite consultations, EM diagnoses, and other LB manifestations in the Netherlands from 2014 onward.

In 2017 and 2021, questionnaires were sent to Dutch GPs to collect data on tick bite consultations and EM diagnoses. The 2021 survey additionally addressed disseminated LB and persistent symptoms attributed to LB. Data were analyzed using a negative binomial distribution, with bootstrapping applied to account for uncertainty.

The population coverage was 51 % in 2017 and 32 % in 2021. The incidence of tick bite consultations per 100,000 was 534 (518–551) in 2017 and 447 (426–470) in 2021. The incidence of EM diagnoses per 100,000 was 150 (145–155) in 2017 and 147 (140–154) in 2021. In 2021, the incidence was 5.0 (4.2–5.9) per 100,000 for disseminated LB and 5.0 (4.4–5.5) per 100,000 for persisting symptoms attributed to LB.

Compared to 2014, GP consultations for tick bites and EM diagnoses had increased in 2017. In 2021, tick bite consultations were lower than in 2017, likely due to COVID-19 restrictions. EM diagnoses were similar to 2017. Disseminated LB was lower in 2021 compared to 2010, whilst persisting symptoms attributed to LB remained stable.

莱姆病（LB）是一种在欧洲流行的媒介传播疾病。如果不治疗，它会引起严重的并发症，一些患者在治疗后会出现持续的症状。在荷兰，蜱叮咬咨询和迁移性红斑（EM）诊断从1994年到2009年增加了两倍，但蜱叮咬咨询下降，EM诊断在2014年稳定下来。本研究调查了2014年以来荷兰蜱虫叮咬咨询、EM诊断和其他LB表现的趋势。2017年和2021年，向荷兰全科医生发送了调查问卷，以收集蜱虫叮咬咨询和急诊诊断的数据。2021年的调查还解决了播散性LB和LB引起的持续症状。数据使用负二项分布进行分析，并采用自举法来解释不确定性。2017年的人口覆盖率为51%，2021年为32%。2017年每10万人中蜱虫叮咬咨询的发生率为534例（518-551例），2021年为447例（426-470例）。2017年每10万人中EM诊断的发病率为150例（145-155例），2021年为147例（140-154例）。2021年，播散性LB的发病率为5.0(4.2-5.9)/ 10万，LB持续症状的发病率为5.0(4.4-5.5)/ 10万。与2014年相比，2017年，蜱虫叮咬和EM诊断的全科医生咨询有所增加。2021年，蜱虫叮咬咨询人数低于2017年，可能是由于COVID-19限制措施。EM诊断与2017年相似。与2010年相比，2021年播散性LB降低，而LB引起的持续症状保持稳定。

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引用次数: 0

Corrigendum to “Spatial distribution and clustering of medically important tick species in Illinois: Implications for tick-borne disease risk” [Ticks and Tick-borne Diseases 16 (2025) 102533] “伊利诺伊州重要医学蜱类的空间分布和聚类：对蜱传疾病风险的影响”[蜱和蜱传疾病16(2025)102533]的勘误表。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102558

Abrar Hussain , Csaba Varga , Brian F. Allan , Nohra Mateus-Pinilla , Rebecca L. Smith

引用次数: 0

Pathogen screening in ticks impacted by microbial reference genomes 微生物参考基因组对蜱病原筛选的影响。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102572

Koray Ergunay , Hein Sprong , Yvonne-Marie Linton

引用次数: 0

Effective control of severe fever with thrombocytopenia syndrome in Daishan County: Correspondence 岱山县发热伴血小板减少综合征有效控制函件。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102574

Hinpetch Daungsupawong , Viroj Wiwanitkit

引用次数: 0

Erratum to “First molecular detection of Anaplasma marginale, Babesia bovis, and hemotropic Mycoplasma spp. in bovine colostrum” [Ticks and Tick-borne Diseases 16(6) (2025) 102553] 牛初乳中边缘性无原体、牛巴贝斯虫和嗜血支原体的首次分子检测[蜱与蜱传疾病16(6)(2025)102553]。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102559

Mayara Campos Lombardi , Nicolas Colácio , Camila de Valgas e Bastos , Sandra Gesteira Coelho , Tiago Facury Moreira , Rodrigo Melo Meneses , Antônio Último de Carvalho , Elias Jorge Facury-Filho , Júlia Angélica Gonçalves Silveira

引用次数: 0

Reply: Response to “Effective control of severe fever with thrombocytopenia syndrome in Daishan County” 答复：对“岱山县发热伴血小板减少综合征疫情有效控制”的答复。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102576

Jiangping Ren

引用次数: 0

Assessing the potential risk of lone star tick, Amblyomma americanum, establishment in California 评估孤星蜱的潜在风险，Amblyomma americanum，建立在加利福尼亚州。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102566

Janet Foley, Francesca Rubino, Drew Kam, Kailyn Lozano

The lone star tick (LST), Amblyomma americanum, is an aggressive human biter and important vector of the causative agents of tick-borne diseases. As geographic ranges of multiple Amblyomma species rapidly expand due to habitat changes and human and other animal movement patterns, there are concerns for establishment of LST in US states with suitable climates, such as California, especially given a dearth in gaps in tick surveillance. Importantly, previous niche modeling confirmed habitat in California along the length of the coast and coast range mountains. We sought data on LSTs and LST risk from 30 different entities including companies that identify and test ticks, natural history and entomology museums and collections, experts, and large databases. These queries and published records yielded records of 76 LSTs from California as well as two Amblyomma cajennense sensu lato, one Amblyomma sabanerae, one Amblyomma maculatum, and five Amblyomma dissimile. Among LSTs, there were 18 adult females, ten males, 13 adults for which sex was not recorded, 22 nymphs, two larvae, and 11 with no stage data. LSTs were recorded only during late spring through late summer, with all three feeding stages superimposed temporally. Active surveillance was conducted at nine sites considered high-risk due to earlier records of LSTs or high probability of establishment on niche modeling, using tick flagging, monitoring ovine and cervid hosts, and circulating a flier; no LSTs were recovered in this activity. We assessed risk for establishment of LSTs in California using invasion theory, prior niche modeling, literature review of ecological constraints on LSTs within their current range, data acquired in retrospective and prospective segments of this study, and expert consultation. Elevated risk is expected particularly along coastal California. Although some of these ticks likely were transported from out of state endemic regions, the findings of 76 LSTs, including all three feeding stages, in multiple counties raises concern that establishment in the future could occur in California.

孤星蜱（Amblyomma americanum）是一种具有攻击性的人类叮咬者，是蜱传疾病病原体的重要媒介。由于栖息地的变化以及人类和其他动物的运动模式，多种蜱虫物种的地理范围迅速扩大，人们担心在美国气候适宜的州（如加利福尼亚州）建立LST，特别是考虑到蜱虫监测方面的不足。重要的是，之前的生态位模型证实了加州沿海岸和海岸山脉的栖息地。我们从30个不同的实体中寻找LST和LST风险的数据，包括鉴定和测试蜱虫的公司、自然历史和昆虫学博物馆和收藏、专家和大型数据库。这些查询和已发表的记录产生了76个来自加利福尼亚的lst记录，以及2个camjenense sensu lato Amblyomma sabanerae， 1个maculatum Amblyomma maculatum和5个disdism Amblyomma。其中雌成虫18只，雄成虫10只，未记录性别的成虫13只，若虫22只，幼虫2只，无龄期记录11只。lst仅在春末至夏末记录，所有三个摄食阶段在时间上重叠。在9个被认为高风险的地点进行了主动监测，因为早期有lst记录或建立生态位模型的可能性很大，使用蜱虫标记，监测羊和宫颈宿主，并散发传单；本次活动未回收lst。我们利用入侵理论、先前的生态位模型、对当前范围内lst的生态约束的文献综述、本研究的回顾性和前瞻性部分获得的数据以及专家咨询来评估在加州建立lst的风险。预计加州沿海地区的风险会增加。尽管其中一些蜱虫可能是从州外的流行地区运来的，但在多个县对76个lst（包括所有三个喂养阶段）的调查结果引起了人们的担忧，即未来可能会在加州建立。

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Seroprevalence of Borrelia burgdorferi sensu lato and incidence of Lyme borreliosis in Switzerland 瑞士感伯氏疏螺旋体血清阳性率及莱姆病发病率。

IF 3.4 2区医学 Q2 INFECTIOUS DISEASES

Ticks and Tick-borne Diseases

Pub Date : 2025-11-01 DOI: 10.1016/j.ttbdis.2025.102568

Rahel Ackermann-Gäumann , Christoph Niederhauser , Peter Gowland , Frederick J. Angulo , Alexandra Loew-Baselli , Gordon Brestrich , Ye Tan , Michelle Covi , Andreas Pilz , James Stark , Antony Croxatto , Reto Lienhard

Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl), is a significant public health concern in Switzerland. Reliable data on seroprevalence and incidence are needed to better understand disease burden and inform prevention strategies. This study aimed to estimate the seroprevalence of Bbsl-specific antibodies and the incidence of symptomatic LB infections in the Swiss adult population.

We analyzed Bbsl-specific IgG antibodies in 2,194 residual plasma samples from blood donors (aged 18–75 years) collected at seven Swiss Red Cross donation centers between September and December 2022. Samples were tested using the Liaison® Borrelia IgG VlsE chemiluminescence immunoassay and confirmed with the SeraSpot Anti-Borrelia-10 IgG assay according to National Reference Laboratory interpretative criteria.

The overall seroprevalence was 6.1%, with higher prevalence in males (8.2%) than in females (2.9%) and regional variation ranging from 1.6% in Genève to 8.8% in Bern. Based on seroprevalence data, the estimated incidence of symptomatic Bbsl infections was 224 cases per 100,000 population per year (PPY). This estimate, although 1.3 times higher, is similar to the incidence derived from the Sentinella surveillance network. Using Sentinella data, clinically diagnosed erythema migrans was the most common manifestation (150 cases per 100,000 PPY), while disseminated forms, confirmed by clinical and laboratory criteria, occurred less frequently (1.0–8.5 cases per 100,000 PPY).

Our findings provide critical insights into the burden of LB in Switzerland, highlight its public health relevance, and reinforce the importance of preventive measures. Future research should focus on longitudinal monitoring and harmonized methodologies to facilitate cross-country comparisons.

莱姆性伯氏疏螺旋体（Borrelia burgdorferi sensus lato, Bbsl）引起的莱姆性伯氏疏螺旋体病（Lyme borrelii， LB）是瑞士的一个重大公共卫生问题。需要关于血清患病率和发病率的可靠数据，以便更好地了解疾病负担并为预防战略提供信息。本研究旨在估计瑞士成年人群中bsl特异性抗体的血清患病率和症状性LB感染的发生率。我们分析了2022年9月至12月期间在七个瑞士红十字会捐赠中心收集的2194份献血者（18-75岁）残留血浆样本中的bbsl特异性IgG抗体。采用Liaison®伯氏疏螺旋体IgG VlsE化学发光免疫分析法对样品进行检测，并根据国家参考实验室解释标准用SeraSpot抗伯氏疏螺旋体-10 IgG测定法进行确认。总体血清患病率为6.1%，男性患病率（8.2%）高于女性（2.9%），区域差异从gen区的1.6%到伯尔尼的8.8%不等。根据血清流行率数据，估计有症状的Bbsl感染发生率为每年每10万人224例（PPY）。这一估计虽然高出1.3倍，但与从Sentinella监测网得出的发病率相似。根据Sentinella数据，临床诊断的移行性红斑是最常见的表现（150例/ 100,000 PPY），而经临床和实验室标准证实的弥散性红斑发生频率较低（1.0-8.5例/ 100,000 PPY）。我们的研究结果对瑞士的LB负担提供了重要的见解，强调了其公共卫生相关性，并强调了预防措施的重要性。今后的研究应侧重于纵向监测和统一的方法，以促进跨国比较。

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