Lancet Infectious Diseases最新文献

{"title":"COVID-19 versus influenza: the need to align policies with COVID-19 realities","authors":"Yan Xie","doi":"10.1016/s1473-3099(25)00001-5","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00001-5","url":null,"abstract":"No Abstract","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"39 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research in brief","authors":"Priya Venkatesan","doi":"10.1016/s1473-3099(25)00029-5","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00029-5","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Bedaquiline monotherapy for leprosy</h2>Monotherapy with bedaquiline, a diarylquinoline used to treat pulmonary multidrug-resistant tuberculosis, is efficacious in patients with multibacillary leprosy, suggests a phase 2, open-label <span><span>study</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> in Brazil. Nine adult patients with previously untreated leprosy consisting of at least six skin lesions received oral bedaquiline 200 mg once daily for 2 weeks, followed by bedaquiline 100 mg three times per week for 6 weeks. After 8 weeks of bedaquiline, patients started standard multidrug therapy</section></section><section><section><h2>RSV vaccination in people who are immunocompromised</h2>A US prospective cohort <span><span>study</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> examined antibody responses to respiratory syncytial virus (RSV) vaccination in patients with immunocompromising conditions. 38 individuals (median age 66 years [IQR 64–72], 50% female) who were planning to receive adjuvanted RSVPreF3-AS01E or nonadjuvanted RSVpreF vaccinations provided blood samples before vaccination and at 2, 4, and 12 weeks after. Only 23 participants (61%) achieved seroconversion by week 4 post-vaccination, defined as a four-fold or greater</section></section><section><section><h2>Vaccine-strain rotavirus in a neonatal intensive care unit</h2>Rotavirus vaccines have reduced rotavirus-associated morbidity and mortality in children worldwide. However, many neonatal intensive care units (NICUs) in the USA do not administer the vaccine to hospitalised children (including preterm infants) due to a theoretical risk of transmission of vaccine strains to unvaccinated infants. A cohort <span><span>study</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> was undertaken over 1 year in a US NICU that routinely administered 226 doses of pentavalent rotavirus vaccine (RV5). Stool samples from only five of</section></section><section><section><h2>Translocation of Ebola virus to human skin surfaces</h2>Ebola virus is spread by direct contact with infected individuals and their bodily fluids, primarily via mucosal transmission. However, infectious virus is also present on the skin surfaces of infected individuals at later times during infection and after death, implicating skin contact as a source of transmission. To understand the mechanism behind skin translocation of the virus, <span><span>researchers</span><svg aria-label=\"Opens in new wind","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"28 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adriaan Willem Sturm","authors":"Sanjeet Bagcchi","doi":"10.1016/s1473-3099(25)00021-0","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00021-0","url":null,"abstract":"<span><figure><span><img alt=\"\" height=\"173\" src=\"https://ars.els-cdn.com/content/image/1-s2.0-S1473309925000210-fx1.jpg\"/><ol><li><span><span>Download: <span>Download high-res image (52KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span>","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"49 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal views on RSV vaccination during the first season of implementation in England and Scotland","authors":"Thomas C Williams, Robin Marlow, Steve Cunningham, Simon B Drysdale, Helen Groves, Dalia Iskander, Xinxue Liu, Mark D Lyttle, Chengetai D Mpamhanga, Shaun O'Hagan, Thomas Waterfield, Damian Roland","doi":"10.1016/s1473-3099(25)00060-x","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00060-x","url":null,"abstract":"No Abstract","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"53 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHO reports gaps in global IPC programmes","authors":"Timothy Jesudason","doi":"10.1016/s1473-3099(25)00026-x","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00026-x","url":null,"abstract":"No Abstract","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"20 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jimmy Carter—a legacy","authors":"Talha Burki","doi":"10.1016/s1473-3099(25)00025-8","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00025-8","url":null,"abstract":"No Abstract","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"79 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious disease surveillance update","authors":"Cahal McQuillan","doi":"10.1016/s1473-3099(25)00023-4","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00023-4","url":null,"abstract":"&lt;h2&gt;Section snippets&lt;/h2&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Hepatitis A in Slovakia&lt;/h2&gt;On Dec 19, 2024, the Regional Public Health Office (RUVZ) in Bratislava, Slovakia, &lt;span&gt;&lt;span&gt;reported&lt;/span&gt;&lt;svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"&gt;&lt;path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt; an increase in the number of hepatitis A cases in all districts of the Bratislava region. According to the RUVZ, 73 cases of hepatitis A were recorded between Jan 1 and Dec 19, 2024, with 24 cases recorded in Dec 1–19 alone. The RUVZ state that vaccination is the most effective method of prevention, and, at this time, they are also emphasising personal hygiene, such as handwashing, as a preventive&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Japanese encephalitis in Australia&lt;/h2&gt;On Dec 31, 2024, Victoria's Department of Health &lt;span&gt;&lt;span&gt;reported&lt;/span&gt;&lt;svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"&gt;&lt;path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt; a probable human case of Japanese encephalitis in a northern area of the Australian state. The first-ever case of Japanese encephalitis in Victoria was reported in 2022, and this is the first recorded case since that mosquito season. Through environmental surveillance, the virus has been detected in mosquitoes and feral pigs, which authorities say indicates that it is circulating in Victoria this summer. The Department of Health&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Measles in Pakistan&lt;/h2&gt;On Dec 31, 2024, it was &lt;span&gt;&lt;span&gt;reported&lt;/span&gt;&lt;svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"&gt;&lt;path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt; that measles cases were on the rise again in Sindh province in Pakistan following a substantial drop in infections over the previous few months. This comes after the country saw its highest number of cases in decades in 2024. The health department's data show that there were more than 13 000 suspected cases, 6670 confirmed cases, and 132 child deaths related to measles last year. Despite the availability of a free and effective vaccine, 350 suspected and 155&lt;/section&gt;&lt;/section&gt;&lt;section&gt;&lt;section&gt;&lt;h2&gt;Gastroenteritis in Brazil&lt;/h2&gt;On Jan 5, 2025, the State Department of Health of São Paulo &lt;span&gt;&lt;span&gt;reported&lt;/span&gt;&lt;svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"&gt;&lt;path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt; an outbreak of gastroenteritis in Guarujá and a possible outbreak in Playa Grande. The full extent of the outbreak is unknown, but it has been reported that there were almost 2000 cases in Guarujá in December, 2024. It is suspected that infections resulted from co","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"22 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid abscess caused by mucormycosis in a child with acute lymphoblastic leukaemia","authors":"Xu Yang, Yufeng Liang, Huiying Wu, Xiaohong Zhang","doi":"10.1016/s1473-3099(24)00753-9","DOIUrl":"https://doi.org/10.1016/s1473-3099(24)00753-9","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Contributors</h2>XY: conceptualisation, investigation, project administration, validation, visualisation, writing of the original draft, and review and editing. YL and HW: investigation, resources, validation, and review and editing. XZ: conceptualisation, investigation, methodology, project administration, resources, validation, supervision, review and editing. All authors had full access to the data and had final responsibility for the decision to submit for publication. Informed written consent for the</section></section><section><section><h2>Declaration of interests</h2>We declare no competing interests.</section></section><section><section><h2>Acknowledgments</h2>This work was supported by the Guangzhou Municipal Science and Technology Project (2024A03J1240).</section></section>","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"60 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hospital and mortality burden of COVID-19 compared with influenza in Denmark: a national observational cohort study, 2022–24","authors":"Peter Bager, Ingrid Bech Svalgaard, Frederikke Kristensen Lomholt, Hanne-Dorthe Emborg, Lasse Engbo Christiansen, Bolette Soborg, Anders Hviid, Lasse S Vestergaard","doi":"10.1016/s1473-3099(24)00806-5","DOIUrl":"https://doi.org/10.1016/s1473-3099(24)00806-5","url":null,"abstract":"<h3>Background</h3>The COVID-19 pandemic has been on a downward trend since May, 2022, but it continues to cause substantial numbers of hospital admissions and deaths. We describe this burden in the 2 years since May, 2022, and compare it with the burden of influenza in Denmark.<h3>Methods</h3>This observational cohort study included residents in Denmark from May 16, 2022, to June 7, 2024. Data were obtained from national registries, including admissions with COVID-19 or influenza (ie, having a positive PCR test for either virus from 14 days before and up to 2 days after the hospital admission date), deaths, sex, age, COVID-19 and influenza vaccination status, comorbidities, and residence in long-term care facilities. Negative binomial regression was used to estimate adjusted incidence rate ratios (aIRRs) to compare rates of hospital admissions between COVID-19 and influenza. To compare the severity of COVID-19 versus influenza among patients admitted to hospital, we used the Kaplan–Meier estimator to produce weighted cumulative incidence curves and adjusted risk ratios (aRRs) of mortality at 30 days between COVID-19 and influenza admissions.<h3>Findings</h3>Among 5 899 170 individuals, COVID-19 admissions (n=24 400) were more frequent than influenza admissions (n=8385; aIRR 2·04 [95% CI 1·38–3·02]), particularly during the first year (May, 2022, to May, 2023) versus the second year (May, 2023, to June, 2024; p=0·0096), in the summer versus the winter (p&lt;0·0001), and among people aged 65 years or older versus younger than 65 years (p&lt;0·0001). The number of deaths was also higher for patients with COVID-19 (n=2361) than patients with influenza (n=489, aIRR 3·19 [95% CI 2·24–4·53]). Among patients admitted in the winter (n=19 286), the risk of mortality from COVID-19 was higher than for influenza (aRR 1·23 [95% CI 1·08–1·37]), particularly among those without COVID-19 and influenza vaccination (1·36 [1·05–1·67]), with comorbidities (1·27 [1·11–1·43]), and who were male (1·36 [1·14–1·59]).<h3>Interpretation</h3>COVID-19 represented a greater disease burden than influenza, with more hospital admissions and deaths, and more severe disease (primarily among non-vaccinated people, those with comorbidities, and male patients). These results highlight the continued need for attention and public health efforts to mitigate the impact of SARS-CoV-2.<h3>Funding</h3>Danish Government.","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"10 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination in Africa—no hesitancy without access","authors":"","doi":"10.1016/s1473-3099(25)00020-9","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00020-9","url":null,"abstract":"No Abstract","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"229 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}