Journal of Psychosomatic Research最新文献_第5页

The associations of spirituality and Hispanic ethnicity with neuroendocrine biomarkers among patients with colorectal cancer 精神信仰和西班牙裔与结直肠癌患者神经内分泌生物标志物的关系。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-30 DOI: 10.1016/j.jpsychores.2024.111865

Objective

Dealing with cancer evokes not only physical and emotional distress, but may also promote resilience through spirituality. Patients with cancer are vulnerable to neuroendocrine dysregulation. This longitudinal observational study examined the degree to which spirituality was associated with neuroendocrine biomarkers and the moderating role of Hispanic ethnicity.

Methods

Participants were adults who were recently diagnosed with colorectal cancer (n = 81, 55 years old, 66% male, 63% Hispanic, 72% advanced cancer, 7 months post-diagnosis). The domains of spirituality (faith, meaning, and peace) and ethnicity (Hispanic vs. non-Hispanic) were self-reported. Cortisol and alpha amylase (sAA) were assayed from saliva samples collected at waking and bedtime on seven consecutive days. Mean levels at waking and bedtime, and diurnal slopes over seven days were calculated. Age and cancer stage were covariates. Results: Overall, patients reported moderate to high levels of spirituality. General linear modeling revealed that greater faith was associated with higher levels of sAA at waking and bedtime as well as more blunted diurnal pattern of sAA only among Hispanic patients (p ≤ .045). Greater peace was associated with steeper diurnal pattern of sAA, regardless of ethnicity (B = 0.021, p = .005). Meaning and cortisol were not significantly associated with study variables.

Conclusions

Findings indicate that presence of peace facing a cancer diagnosis associated with neuroendocrine regulation, whereas drawing on one's faith, particularly among Hispanic patients, associated with neuroendocrine dysregulation during the first months after the diagnosis. Further investigations of psychobiobehavioral moderators and mediators for healthy neuroendocrine functioning among patients with cancer are warranted.

目的应对癌症不仅会引起身体和精神上的痛苦，还可能通过精神疗法提高复原力。癌症患者容易出现神经内分泌失调。这项纵向观察研究探讨了灵性与神经内分泌生物标志物的关联程度以及西班牙裔的调节作用：参与者为最近被诊断出患有结直肠癌的成年人（n = 81，55 岁，66% 为男性，63% 为西班牙裔，72% 为晚期癌症，诊断后 7 个月）。精神领域（信仰、意义与和平）和种族（西班牙裔与非西班牙裔）均为自我报告。连续七天在起床和就寝时采集唾液样本，化验皮质醇和α-淀粉酶（sAA）。计算出醒时和睡前的平均水平以及七天内的昼夜斜率。年龄和癌症分期是协变量：结果：总体而言，患者报告的精神信仰程度为中度到高度。一般线性建模显示，只有在西班牙裔患者中，较高的信仰与较高的醒时和睡前 sAA 水平以及较钝化的 sAA 日间模式有关（p ≤ .045）。无论种族如何，更平和的情绪与更陡峭的 sAA 日间模式相关（B = 0.021，p = .005）。意义和皮质醇与研究变量无明显关联：研究结果表明，面对癌症诊断时的平和心态与神经内分泌调节有关，而在诊断后的头几个月中，依靠自己的信仰（尤其是在西班牙裔患者中）与神经内分泌失调有关。有必要进一步研究癌症患者神经内分泌功能健康的心理生物行为调节因素和中介因素。

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引用次数: 0

Changes in illness perception, pain catastrophizing, and psychological distress following hand surgeon consultation: A prospective study 手外科医生会诊后疾病感知、疼痛灾难化和心理困扰的变化：前瞻性研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-27 DOI: 10.1016/j.jpsychores.2024.111861

Background

Baseline mindset factors are important factors that influence treatment decisions and outcomes. Theoretically, improving the mindset prior to treatment may improve treatment decisions and outcomes. This prospective cohort study evaluated changes in patients' mindset following hand surgeon consultation. Additionally, we assessed if the change in illness perception differed between surgical and nonsurgical patients.

Methods

The primary outcome was illness perception, measured using the total score of the Brief Illness Perception Questionnaire (B-IPQ, range 0–80). Secondary outcomes were the B-IPQ subscales, pain catastrophizing (measured using the Pain Catastrophizing Scale (PCS)), and psychological distress (measured using the Patient Health Questionnaire-4).

Results

A total of 276 patients with various hand and wrist conditions completed the mindset questionnaires before and after hand surgeon consultation (median time interval: 15 days). The B-IPQ total score improved from 39.7 (±10.6) before to 35.8 (±11.3) after consultation (p < 0.0001, Cohen's d = 0.36); scores also improved for the B-IPQ subscales Coherence, Concern, Emotional Response, Timeline, Treatment Control, and Identity and the PCS. There were no changes in the other outcomes. Surgical patients improved on the B-IPQ subscales Treatment Control and Timeline, while nonsurgical patients did not.

Conclusions

Illness perception and pain catastrophizing improved following hand surgeon consultation, suggesting that clinicians may actively influence the patients' mindset during consultations, and that they may try to enhance this effect to improve outcomes. Furthermore, surgical patients improved more in illness perceptions, indicating that nonsurgical patients may benefit from a more targeted strategy for changing mindset.

背景：基线心态因素是影响治疗决策和结果的重要因素。从理论上讲，改善治疗前的心态可能会改善治疗决策和治疗效果。这项前瞻性队列研究评估了手外科医生会诊后患者心态的变化。此外，我们还评估了手术和非手术患者在疾病认知方面的变化是否存在差异：主要结果是疾病感知，使用简明疾病感知问卷（B-IPQ，范围 0-80）的总分进行测量。次要结果为 B-IPQ 分量表、疼痛灾难化（使用疼痛灾难化量表 (PCS) 测量）和心理困扰（使用患者健康问卷-4 测量）：共有 276 名患有各种手部和腕部疾病的患者在手外科医生会诊前后（中位时间间隔：15 天）填写了心态问卷。B-IPQ总分从就诊前的39.7（±10.6）分提高到就诊后的35.8（±11.3）分（p 结论：就诊前和就诊后患者的心态均有所改善：手外科医生会诊后，患者的疾病感知和疼痛灾难化程度均有所改善，这表明临床医生在会诊过程中可能会积极影响患者的心态，他们可以尝试加强这种影响，以改善治疗效果。此外，手术患者在疾病感知方面的改善更大，这表明非手术患者可能会受益于更有针对性的改变心态策略。

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引用次数: 0

Depression, anxiety, and development of obesity from childhood to young adulthood in China 抑郁、焦虑与中国儿童至青年期肥胖症的发展

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-25 DOI: 10.1016/j.jpsychores.2024.111867

Objective

To examine the cross-sectional and longitudinal bidirectional associations of depression and anxiety symptoms with the development of obesity over time among children and adolescents in different age groups from childhood to young adulthood.

Methods

This is a three-wave longitudinal study that included >200,000 school-aged children between 5 and 18 years. Participants were assessed at baseline, 6 months, and 12 months. Depression and anxiety symptoms, as well as participants' weight and height, were collected at each assessment. The cross-sectional associations between obesity and depression or anxiety were examined through ANOVA and Chi-square tests. Multivariable logistic regression analyses were performed to investigate their longitudinal bidirectional associations.

Results

The prevalence of obesity reached a peak in the age group between 12 and 14 years. Concurrently, higher mean BMI and obesity prevalence were associated with more severe symptoms of depression and anxiety in each age group (ps < 0.001). Longitudinally, depression and anxiety significantly increased the risk of development of obesity over time (odds ratios [ORs] = 1.08 to 1.77). Moreover, obesity significantly aggravated the risk of development of depression (ORs = 1.17 to 1.68) and anxiety (ORs = 1.25 to 1.71) over time and hindered the alleviation of depressive (ORs = 0.68 to 0.79) and anxiety symptoms (ORs = 0.73 to 0.74).

Conclusion

Findings suggest that there were bidirectional associations between obesity and psychological distress. It may be important to continuously track BMI and psychological conditions for children and adolescents over time to avoid the reinforcement of their negative reciprocal interactions.

目标研究从儿童期到青年期不同年龄段的儿童和青少年中，抑郁和焦虑症状与肥胖发展之间的横向和纵向双向关系。方法这是一项三波纵向研究，共纳入了>20万名5至18岁的学龄儿童。分别在基线、6 个月和 12 个月时对参与者进行评估。每次评估都会收集抑郁和焦虑症状以及参与者的体重和身高。肥胖与抑郁或焦虑之间的横断面关联通过方差分析和卡方检验进行检验。结果12至14岁年龄组的肥胖率达到高峰。同时，在每个年龄组中，较高的平均体重指数和肥胖率与较严重的抑郁和焦虑症状有关（PS < 0.001）。纵向来看，随着时间的推移，抑郁和焦虑会显著增加肥胖症的发病风险（几率比 [ORs] = 1.08 至 1.77）。此外，随着时间的推移，肥胖会明显增加抑郁（ORs = 1.17 至 1.68）和焦虑（ORs = 1.25 至 1.71）的发病风险，并阻碍抑郁症状（ORs = 0.68 至 0.79）和焦虑症状（ORs = 0.73 至 0.74）的缓解。研究结果表明，肥胖与心理困扰之间存在双向关联，因此，长期持续跟踪儿童和青少年的体重指数和心理状况，以避免两者之间的负向相互作用得到强化，可能具有重要意义。

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引用次数: 0

Tara Petzke, 2024 EAPM Elsevier young investigator award recipient, on symptom reporting 2024 年 EAPM Elsevier 青年研究员奖获得者 Tara Petzke 谈症状报告

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-25 DOI: 10.1016/j.jpsychores.2024.111866

引用次数: 0

P factor in children with chronic physical illness 患有慢性身体疾病儿童的 P 因子。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-23 DOI: 10.1016/j.jpsychores.2024.111863

Background

The p factor represents the overall liability for the development of mental illness. While evidence supporting the p factor in adults has been reported, studies in children are fewer, and none have examined the p factor in children with chronic physical illness (CPI).

Objective

We aimed to model the p factor in a longitudinal sample of children with CPI using a parent-reported checklist and examine its construct validity against a structured diagnostic interview.

Methods

We used data from 263 children aged 2–16 years diagnosed with a CPI who were enrolled in the Multimorbidity in Children and Youth across the Life-course (MY LIFE) study. The p factor was modelled using the Emotional Behavioural Scales over 24 months using confirmatory factor analysis. Validation of the p factor was set against the Mini International Neuropsychiatric Interview for Children and Adolescents.

Results

Factorial evidence supported the p factor, modelled using a bi-factor structure, compared to a standard correlated-factors (i.e., two-factor) structure [Δχ² = 9.66(4), p = 0.047]. p factor scores were correlated with the number of different mental illness diagnoses (r = 0.71) and total number of diagnoses (r = 0.72). Dose-response relationships were shown for the number of different diagnoses (p < 0.001) and total number of diagnoses (p < 0.001).

Conclusion

In this first study of the p factor in children with CPI, we showed evidence of its bi-factor structure and associations with mental illness diagnoses. Mental comorbidity in children with CPI is pervasive and warrants transdiagnostic approaches to integrated pediatric care.

背景：p 因子代表了精神疾病发展的总体责任。尽管有证据显示成人存在 p 因素，但针对儿童的研究却较少，而且没有一项研究对患有慢性躯体疾病（CPI）的儿童进行了 p 因素研究：我们的目的是使用家长报告的核对表，在慢性躯体疾病儿童的纵向样本中建立 p 因子模型，并根据结构化诊断访谈检验其构建有效性：我们使用了263名被诊断患有CPI的2-16岁儿童的数据，这些儿童参加了儿童和青少年一生中的多病症（MY LIFE）研究。通过确认性因子分析，使用情绪行为量表对 p 因子进行了 24 个月的建模。根据儿童和青少年迷你国际神经精神访谈对 p 因子进行了验证：与标准的相关因子（即双因子）结构相比，使用双因子结构建模的因子支持 p 因子[Δχ2 = 9.66(4)，p = 0.047]。不同诊断数（p 结论：p因子得分与诊断数之间存在剂量-反应关系：在这项首次针对 CPI 儿童的 p 因子研究中，我们发现了其双因子结构及其与精神疾病诊断相关性的证据。CPI患儿的精神疾病合并症非常普遍，需要采用跨诊断方法进行综合儿科护理。

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引用次数: 0

Effects of app-based relaxation techniques on perceived momentary relaxation: Observational data analysis in people with cancer 基于应用程序的放松技巧对瞬间放松感知的影响：癌症患者的观察数据分析。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-23 DOI: 10.1016/j.jpsychores.2024.111864

Objective

To examine the effects of six relaxation techniques on perceived momentary relaxation and a possible association of relaxation effects with time and practice experience in people with cancer.

Methods

We used data from participants with cancer in a larger study practicing app-based relaxation techniques over 10 weeks, assessed momentary relaxation before and after every third relaxation practice, and analyzed momentary relaxation changes with a linear mixed-effects model.

Results

The sample included 611 before-after observations from 91 participants (70 females (76.9%)) with a mean age of 55.43 years (SD 10.88). We found moderate evidence for variations in momentary relaxation changes across different techniques (P = .026), with short meditation, mindfulness meditation, guided imagery, and progressive muscle relaxation more frequently observed and leading to more relaxation than body scan and walking meditation. Furthermore, we found moderate evidence for increasing momentary relaxation changes over time (P = .046), but no evidence for an association between momentary relaxation and the number of previous observations (proxy for practice experience; P = .47).

Conclusion

We compared six app-based relaxation techniques in a real-life setting of people with cancer. The observed variations in perceived momentary relaxation appear to correspond with the popularity of the techniques used: The most popular relaxation techniques were the most effective and the least popular were the least effective. The effects increased over time, likely caused by dropout of individuals who gained no immediate benefit. Our findings open an interesting avenue for future research to better understand which relaxation techniques work best for whom in which situations.

Trial Registration

DRKS00027546; https://drks.de/search/en/trial/DRKS00027546

目的研究六种放松技巧对癌症患者瞬间放松感知的影响，以及放松效果与时间和练习经验之间可能存在的关联：我们使用了一项大型研究中癌症患者在 10 周内练习基于应用程序的放松技巧的数据，在每三次放松练习前后对瞬间放松进行了评估，并使用线性混合效应模型分析了瞬间放松的变化：样本包括 91 名参与者（70 名女性，占 76.9%）的 611 个前后观察结果，平均年龄为 55.43 岁（标准差为 10.88）。我们发现有中等程度的证据表明，不同技巧的瞬间放松变化存在差异（P = .026），与身体扫描和步行冥想相比，短时冥想、正念冥想、引导想象和渐进式肌肉放松的观察频率更高，带来的放松也更多。此外，我们还发现了随着时间推移瞬间放松变化增加的中等程度证据（P = .046），但没有证据表明瞬间放松与之前观察次数（代表练习经验；P = .47）之间存在关联：我们在癌症患者的真实生活环境中比较了六种基于应用程序的放松技巧。观察到的瞬间放松感的变化似乎与所使用技巧的流行程度相符：最受欢迎的放松技巧效果最好，而最不受欢迎的技巧效果最差。随着时间的推移，效果会逐渐增强，这可能是由于没有立即获益的人退出了研究。我们的研究结果为今后的研究开辟了一条有趣的途径，以更好地了解哪些放松技巧在哪些情况下对哪些人最有效：DRKS00027546; https://drks.de/search/en/trial/DRKS00027546.

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引用次数: 0

Cultural resonance and medical practice: Heart rate variability test in Taiwanese psychiatry clinics 文化共鸣与医疗实践：台湾精神病诊所的心率变异性测试

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-17 DOI: 10.1016/j.jpsychores.2024.111860

引用次数: 0

Which patients are at risk of developing symptom diagnoses that persist for more than a year in primary care? Development and external validation of a prediction model 哪些患者有可能在初级保健中出现持续一年以上的症状诊断？预测模型的开发和外部验证

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-15 DOI: 10.1016/j.jpsychores.2024.111859

Objectives

To train, test and externally validate a prediction model that supports General Practitioners (GPs) in early identification of patients at risk of developing symptom diagnoses that persist for more than a year.

Methods

We retrospectively collected and selected all patients having episodes of symptom diagnoses during the period 2008 and 2021 from the Family Medicine Network (FaMe-Net) database. From this group, we identified symptom diagnoses that last for less than a year and symptom diagnoses that persist for more than a year. Multivariable logistic regression analysis using a backward selection was used to assess which factors were most predictive for developing symptom diagnoses that persist for more than a year. Performance of the model was assessed using calibration and discrimination (AUC) measures. External validation was tested using data between 2018 and 2022 from AHON-registry, a primary care electronic health records data registry including 73 general practices from the north and east regions of the Netherlands and about 460, 795 patients.

Results

From the included 47,870 patients with a symptom diagnosis in the FaMe-Net registry, 12,481 (26.1%) had a symptom diagnosis that persisted for more than a year. Older age (≥ 75 years: OR = 1.30, 95% CI [1.19, 1.42]), having more previous symptom diagnoses (≥ 3: 1.11, [1.05, 1.17]) and more contacts with the GP over the last 2 years (≥ 10 contacts: 5.32, [4.80, 5.89]) were predictive of symptom diagnoses that persist for more than a year with a marginally acceptable discrimination (AUC 0.70, 95% CI [0.69–0.70]). The external validation showed poor performance with an AUC of 0.64 ([0.63–0.64]).

Conclusion

A clinical prediction model based on age, number of previous symptom diagnoses and contacts might help the GP to early identify patients developing symptom diagnoses that persist for more than a year. However, the performance of the original model is limited. Hence, the model is not yet ready for a large-scale implementation.

方法我们从家庭医学网络（FaMe-Net）数据库中回顾性地收集并选择了 2008 年至 2021 年期间所有出现症状诊断的患者。我们从中找出了持续时间少于一年的症状诊断和持续时间超过一年的症状诊断。我们使用反向选择的多变量逻辑回归分析来评估哪些因素对持续一年以上的症状诊断最具预测性。模型的性能通过校准和区分度（AUC）进行评估。使用AHON-登记处2018年至2022年的数据进行了外部验证，该登记处是一个初级保健电子健康记录数据登记处，包括荷兰北部和东部地区的73家全科诊所和约460 795名患者。结果在FaMe-Net登记处纳入的47870名有症状诊断的患者中，有12481人（26.1%）的症状诊断持续一年以上。年龄较大（≥ 75 岁：OR = 1.30，95% CI [1.19，1.42]）、既往症状诊断次数较多（≥ 3 次：1.11，[1.05，1.17]）以及过去 2 年中与全科医生接触次数较多（≥ 10 次：5.32，[4.80，5.89]）均可预测持续一年以上的症状诊断，其区分度略可接受（AUC 0.70，95% CI [0.69-0.70]）。结论基于年龄、既往症状诊断次数和接触次数的临床预测模型可帮助全科医生及早发现症状诊断持续一年以上的患者。然而，原始模型的性能有限。因此，该模型尚未准备好大规模实施。

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引用次数: 0

The weight of weights: Causal impact of overweight on major depressive disorder and its disparate association with suicide attempts in over 450,000 individuals of European ancestry (AM-SRNMA 003) 体重的重量：超重对重度抑郁障碍的因果影响及其与超过 45 万欧洲血统的自杀企图的不同关联（AM-SRNMA 003）

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-14 DOI: 10.1016/j.jpsychores.2024.111858

Aim

Some studies and societal discussions have suggested a potential link between overweight and a higher risk of mental disorders and suicidal ideation. However, the causal relationships between these factors remain unclear. This study aims to assess the bidirectional causal associations between overweight and mental disorders, including suicidal attempts.

Method

We conducted a Two-Sample Mendelian Randomization study utilizing data from over 450,000 individuals of European ancestry sourced from a comprehensive Genome-Wide Association Study database. We chose single-nucleotide polymorphisms as instrumental variables.

Results

Our analyses consistently supported a unidirectional causal association of overweight with the increased risk of major depressive disorder (MDD, β = 0.152, se = 0.069, P = 0.027), bipolar affective disorders (BD, β = 0.197, se = 0.092, P = 0.033), and attention-deficit / hyperactivity disorder (ADHD, β = 0.308, se = 0.080, P = 1.366 × 10⁻⁴). We observed no significant causal relationships for the exposure of overweight to anxiety disorder (AD), manic episode (MA), panic disorder (PD), schizophrenia (SZ), substance use disorder (SUD), autism spectrum disorder (ASD), ever attempted suicide, recent thoughts of suicide or self-harm, and suicide or other intentional self-harm events.

Conclusion

This study has provided evidence for the causal relationship between overweight and MDD, BD, ADHD, with no observed relationship between overweight and AD, MA, PD, SZ, SUD, ASD, ever attempted suicide, recent thoughts of suicide or self-harm, and suicide or other intentional self-harm events.

目的一些研究和社会讨论表明，超重与较高的精神障碍和自杀意念风险之间存在潜在联系。然而，这些因素之间的因果关系仍不明确。本研究旨在评估超重与精神障碍（包括自杀企图）之间的双向因果关系。方法我们利用来自全基因组关联研究综合数据库的超过 45 万名欧洲血统个体的数据，开展了一项双样本孟德尔随机研究。结果我们的分析一致支持超重与重度抑郁障碍（MDD，β = 0.152，se = 0.069，P = 0.027）、双相情感障碍（BD，β = 0.197，se = 0.092，P = 0.033）和注意缺陷/多动障碍（ADHD，β = 0.308，se = 0.080，P = 1.366 × 10-4）的单向因果关系。我们观察到，超重与焦虑症（AD）、躁狂症（MA）、恐慌症（PD）、精神分裂症（SZ）、药物使用障碍（SUD）、自闭症谱系障碍（ASD）、曾经自杀未遂、最近有自杀或自残念头以及自杀或其他故意自残事件之间没有明显的因果关系。结论本研究为超重与 MDD、BD、ADHD 之间的因果关系提供了证据，但未观察到超重与 AD、MA、PD、SZ、SUD、ASD、曾试图自杀、最近有自杀或自残念头以及自杀或其他故意自残事件之间存在关系。

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引用次数: 0

Genetic causal relationship between placental weight and autism spectrum disorder: A two-sample Mendelian randomization study 胎盘重量与自闭症谱系障碍之间的遗传因果关系：双样本孟德尔随机研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-06 DOI: 10.1016/j.jpsychores.2024.111857

Zhao Liu

Object

Previous research has suggested an association between placental tissue abnormalities and the diagnosis of autism spectrum disorder. This study aims to explore the causal relationship between placental weight and autism spectrum disorder.

Methods

This study employed Mendelian randomization analysis to investigate the potential causal relationship between placental weight and autism spectrum disorder. The study design involved two sample populations, with data for the exposed population sourced from previous studies focusing on PW, and data for the outcome population obtained from the Integrative Psychiatric Research and the Psychiatric Genomics Consortium study. To ensure the robustness of the results, three sensitivity analyses were performed, including heterogeneity testing, pleiotropy testing, and a leave-one-out analysis. The inverse variance weighted method served as the gold standard for the Mendelian randomization analysis.

Results

The results of the first analysis revealed a significant correlation between an increase in placental weight and an elevated risk of autism spectrum disorder (p = 0.02). Sensitivity analysis detected heterogeneity and outliers. After removing two outlier SNPs in the second round of analysis, the results still supported a genetic causal relationship between placental weight and autism spectrum disorder (p = 0.01). The second-round sensitivity analysis did not reveal any heterogeneity or outliers.

Conclusion

Our study provides compelling evidence supporting a causal relationship between elevated placental weight and increased risk of autism spectrum disorder. These findings underscore the significance of placental development in the etiology of autism spectrum disorder and propose a potential early predictive indicator for autism spectrum disorder.

研究目的以往的研究表明，胎盘组织异常与自闭症谱系障碍诊断之间存在关联。本研究旨在探讨胎盘重量与自闭症谱系障碍之间的因果关系：本研究采用孟德尔随机分析法调查胎盘重量与自闭症谱系障碍之间的潜在因果关系。研究设计涉及两个样本人群，暴露人群的数据来源于以往以PW为重点的研究，而结果人群的数据则来源于综合精神病学研究和精神病学基因组学联合会的研究。为确保研究结果的稳健性，研究人员进行了三项敏感性分析，包括异质性检验、多效性检验和剔除分析。反方差加权法作为孟德尔随机分析的金标准：第一项分析结果显示，胎盘重量增加与自闭症谱系障碍风险升高之间存在显著相关性（p = 0.02）。敏感性分析发现了异质性和异常值。在第二轮分析中剔除两个异常 SNP 后，结果仍然支持胎盘重量与自闭症谱系障碍之间存在遗传因果关系（p = 0.01）。第二轮敏感性分析未发现任何异质性或异常值：我们的研究提供了令人信服的证据，支持胎盘重量升高与自闭症谱系障碍风险增加之间存在因果关系。这些发现强调了胎盘发育在自闭症谱系障碍病因学中的重要性，并提出了一个潜在的自闭症谱系障碍早期预测指标。

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引用次数: 0