Journal of Psychosomatic Research最新文献_第5页

EAPM 2026 Florence EAPM 2026佛罗伦萨

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-09 DOI: 10.1016/S0022-3999(26)00010-3

引用次数: 0

Stroke mortality in patients with mental health disorders; a cohort study from the Spanish hospital discharge records 精神健康障碍患者脑卒中死亡率；一项来自西班牙出院记录的队列研究

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-09 DOI: 10.1016/j.jpsychores.2026.112534

Luis Ayerbe , Enrique Barbero-Pablos , Quintí Foguet-Boreu , María Pérez-Piñar , Salma Ayis

Introduction

Evidence on the clinical outcomes of stroke for patients with psychiatric disorders is poor. It is also unclear if the prognosis of stroke has improved over the last two decades for those with mental health conditions. The aims of this study are first, to compare the hospital mortality between 2019 and 2023 of stroke for patients with and without depression, anxiety, schizophrenia, bipolar, or personality disorders, and second, to investigate whether the stroke mortality in 2019–2023 is lower than in 2005–2009, for those with psychiatric conditions.

Methods

Data from all stroke patients registered in the Spanish Hospital Discharge Records were used. The variables registered for each patient include sociodemographics, mortality, and up to 20 diagnoses of past medical history. Multivariable logistic regression models were used in the analyses.

Results

Between 2019 and 2023, 311528 patients were registered, of which, 14.40% died. Mortality of ischaemic stroke was higher for patients with schizophrenia OR(CI): 1.63(1. 30-2.04), bipolar OR(CI): 1.39(1. 10-1.77), or personality disorders OR(CI): 1.54(1. 13-2.09). The mortality of haemorrhagic stroke was increased for patients with schizophrenia OR(CI): 1.69(1. 29-2.23). There was a significant reduction in mortality of ischaemic and haemorrhagic stroke, for the whole population, between 2005 and 2009 and 2019–2023. There was no significant reduction in mortality of ischaemic stroke, for those with depression, anxiety, schizophrenia, bipolar, or personality disorders. There was no significant reduction in mortality of haemorrhagic stroke for patients with depression, schizophrenia, or bipolar disorders.

Conclusion

Psychiatric disorders are associated with higher stroke mortality, that has not declined between 2005 and 2009 and 2019–2023.

关于精神障碍患者脑卒中临床结局的证据很少。同样不清楚的是，在过去的20年里，对于那些有精神健康问题的人来说，中风的预后是否有所改善。本研究的目的首先是比较2019年至2023年患有和不患有抑郁症、焦虑症、精神分裂症、双相情感障碍或人格障碍的患者的中风住院死亡率，其次是调查2019-2023年患有精神疾病的患者的中风死亡率是否低于2005-2009年。方法：采用西班牙医院出院记录中登记的所有脑卒中患者的数据。每位患者登记的变量包括社会人口统计学、死亡率和多达20项既往病史诊断。在分析中使用了多变量逻辑回归模型。结果：2019 - 2023年，共登记31528例患者，其中14.40%死亡。精神分裂症患者缺血性卒中死亡率更高OR(CI): 1.63。30-2.04)，双相OR(CI): 1.39(1。10-1.77)或人格障碍or (CI): 1.54（1.77）。13 - 2.09)。精神分裂症患者出血性卒中的死亡率OR(CI): 1.69(1。29日- 2.23)。2005年至2009年和2019年至2023年期间，全体人口的缺血性和出血性中风死亡率显著降低。对于那些患有抑郁症、焦虑症、精神分裂症、双相情感障碍或人格障碍的患者，缺血性中风的死亡率没有显著降低。对于患有抑郁症、精神分裂症或双相情感障碍的患者，出血性中风的死亡率没有显著降低。结论：精神障碍与较高的脑卒中死亡率相关，在2005 - 2009年和2019-2023年期间没有下降。

{"title":"Stroke mortality in patients with mental health disorders; a cohort study from the Spanish hospital discharge records","authors":"Luis Ayerbe , Enrique Barbero-Pablos , Quintí Foguet-Boreu , María Pérez-Piñar , Salma Ayis","doi":"10.1016/j.jpsychores.2026.112534","DOIUrl":"10.1016/j.jpsychores.2026.112534","url":null,"abstract":"<div><h3>Introduction</h3><div>Evidence on the clinical outcomes of stroke for patients with psychiatric disorders is poor. It is also unclear if the prognosis of stroke has improved over the last two decades for those with mental health conditions. The aims of this study are first, to compare the hospital mortality between 2019 and 2023 of stroke for patients with and without depression, anxiety, schizophrenia, bipolar, or personality disorders, and second, to investigate whether the stroke mortality in 2019–2023 is lower than in 2005–2009, for those with psychiatric conditions.</div></div><div><h3>Methods</h3><div>Data from all stroke patients registered in the Spanish Hospital Discharge Records were used. The variables registered for each patient include sociodemographics, mortality, and up to 20 diagnoses of past medical history. Multivariable logistic regression models were used in the analyses.</div></div><div><h3>Results</h3><div>Between 2019 and 2023, 311528 patients were registered, of which, 14.40% died. Mortality of ischaemic stroke was higher for patients with schizophrenia OR(CI): 1.63(1. 30-2.04), bipolar OR(CI): 1.39(1. 10-1.77), or personality disorders OR(CI): 1.54(1. 13-2.09). The mortality of haemorrhagic stroke was increased for patients with schizophrenia OR(CI): 1.69(1. 29-2.23). There was a significant reduction in mortality of ischaemic and haemorrhagic stroke, for the whole population, between 2005 and 2009 and 2019–2023. There was no significant reduction in mortality of ischaemic stroke, for those with depression, anxiety, schizophrenia, bipolar, or personality disorders. There was no significant reduction in mortality of haemorrhagic stroke for patients with depression, schizophrenia, or bipolar disorders.</div></div><div><h3>Conclusion</h3><div>Psychiatric disorders are associated with higher stroke mortality, that has not declined between 2005 and 2009 and 2019–2023.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112534"},"PeriodicalIF":3.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personality disorders in patients with fibromyalgia 纤维肌痛患者的人格障碍

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-09 DOI: 10.1016/j.jpsychores.2026.112536

Eli Magen , Akim Geishin , Abraham Weizman , Israel Magen , Eugene Merzon , Shai Ashkenazi , Shlomo Vinker , Ariel Israel

Background

Fibromyalgia (FM) frequently co-occurs with mental disorders, but population-scale estimates for personality disorders (PDs) and cluster-specific patterns over extended horizons are limited. We quantified cross-sectional prevalence and 20-year cumulative incidence of recorded PD diagnoses in FM versus matched controls, and assessed the impact of diagnostic opportunity.

Methods

We performed a retrospective matched-cohort study within a nationwide Israeli health system. Adults with FM (N = 15,869) were matched 1:5 to controls (N = 79,345) on sex, age, and enrollment year. Outcomes were ICD-10 PD codes (F60–F61; ancillary F63–F69). Cross-sectional prevalence at baseline and end-of-follow-up was compared using conditional logistic regression (odds ratios [ORs], 95% CIs) with false-discovery-rate. Among participants PD-free at baseline, 20-year cumulative incidence (“risk”) was estimated with risk differences (RD, percentage points) and risk ratios (RR) using Wilson and log-Wald intervals. A surveillance-calibrated sensitivity analysis scaled RRs by the FM:control psychiatry-visit ratio to approximate adjusted RRs (aRRs).

Results

At baseline, any PD was more prevalent in FM than controls (1.84% vs 0.49%; OR 3.79, 95% CI 3.26–4.42; q < 0.001), with pronounced elevations in Cluster B—especially borderline PD (F60.31)—and smaller signals in Cluster C (avoidant, F60.6). At the end of follow-up, contrasts persisted or strengthened (any PD 2.85% vs 0.57%; OR 5.11, 4.48–5.82; q < 0.001). Among those PD-free at baseline, 20-year risk remained higher in FM (any PD 1.03% vs 0.08%; RD 0.95 pp., 0.78–1.14; RR 12.87, 9.62–17.22), driven by Cluster B (borderline 0.20% vs 0.02%; RD 0.19 pp.; RR 12.34, 6.48–23.51). Surveillance calibration attenuated but did not eliminate Cluster-B excess (e.g., borderline aRR ≈ 3.07).

Conclusions

FM is associated with a selective, durable enrichment of Cluster-B PDs—most notably borderline—observable cross-sectionally and as long-term cumulative risk, only partly explained by diagnostic opportunity. Findings support routine PD screening within FM care and motivate mechanistic work on immuno-neuroendocrine and frontolimbic pathways.

背景纤维肌痛（FM）经常与精神障碍同时发生，但对人格障碍（pd）和群体特定模式的人群规模估计是有限的。我们量化了FM组PD诊断的横断面患病率和20年累积发病率，并评估了诊断机会的影响。方法我们在以色列全国卫生系统中进行了一项回顾性匹配队列研究。FM患者（N = 15,869）与对照组（N = 79,345）按性别、年龄和入组年份进行1:5匹配。结果为ICD-10 PD编码（F60-F61，辅助F63-F69）。基线和随访结束时的横断面患病率采用条件logistic回归（优势比[ORs]， 95% ci）和假发现率进行比较。在基线时无pd的参与者中，使用Wilson和log-Wald区间估计20年累积发病率（“风险”）与风险差异（RD，百分点）和风险比（RR）。监测校准的敏感性分析通过FM：对照精神科就诊比率将RRs缩放为近似调整后的RRs （aRRs）。结果在基线时，任何PD在FM中都比对照组更普遍（1.84% vs 0.49%; OR 3.79, 95% CI 3.26-4.42; q < 0.001），在b类中明显升高，尤其是边缘性PD (F60.31)，而在C类中信号较小（F60.6）。在随访结束时，对比持续或加强（任何PD为2.85% vs 0.57%； or为5.11,4.48-5.82;q < 0.001）。在基线时无PD的患者中，受B类驱动，FM的20年风险仍然较高（任何PD为1.03% vs 0.08%； RD为0.95 pp., 0.78-1.14； RR为12.87,9.62-17.22）（边缘性0.20% vs 0.02%； RD为0.19 pp.； RR为12.34,6.48-23.51）。监测校准减弱，但没有消除簇b过量（例如，边缘aRR≈3.07）。结论：fm与b组pds的选择性、持续性富集（最明显的是在横断面上观察到的边缘性）和长期累积风险相关，诊断机会只能部分解释这一点。研究结果支持在FM护理中进行常规PD筛查，并激发免疫神经内分泌和额叶通路的机制工作。

{"title":"Personality disorders in patients with fibromyalgia","authors":"Eli Magen , Akim Geishin , Abraham Weizman , Israel Magen , Eugene Merzon , Shai Ashkenazi , Shlomo Vinker , Ariel Israel","doi":"10.1016/j.jpsychores.2026.112536","DOIUrl":"10.1016/j.jpsychores.2026.112536","url":null,"abstract":"<div><h3>Background</h3><div>Fibromyalgia (FM) frequently co-occurs with mental disorders, but population-scale estimates for personality disorders (PDs) and cluster-specific patterns over extended horizons are limited. We quantified cross-sectional prevalence and 20-year cumulative incidence of recorded PD diagnoses in FM versus matched controls, and assessed the impact of diagnostic opportunity.</div></div><div><h3>Methods</h3><div>We performed a retrospective matched-cohort study within a nationwide Israeli health system. Adults with FM (<em>N</em> = 15,869) were matched 1:5 to controls (<em>N</em> = 79,345) on sex, age, and enrollment year. Outcomes were ICD-10 PD codes (F60–F61; ancillary F63–F69). Cross-sectional prevalence at baseline and end-of-follow-up was compared using conditional logistic regression (odds ratios [ORs], 95% CIs) with false-discovery-rate. Among participants PD-free at baseline, 20-year cumulative incidence (“risk”) was estimated with risk differences (RD, percentage points) and risk ratios (RR) using Wilson and log-Wald intervals. A surveillance-calibrated sensitivity analysis scaled RRs by the FM:control psychiatry-visit ratio to approximate adjusted RRs (aRRs).</div></div><div><h3>Results</h3><div>At baseline, any PD was more prevalent in FM than controls (1.84% vs 0.49%; OR 3.79, 95% CI 3.26–4.42; q < 0.001), with pronounced elevations in Cluster B—especially borderline PD (F60.31)—and smaller signals in Cluster C (avoidant, F60.6). At the end of follow-up, contrasts persisted or strengthened (any PD 2.85% vs 0.57%; OR 5.11, 4.48–5.82; q < 0.001). Among those PD-free at baseline, 20-year risk remained higher in FM (any PD 1.03% vs 0.08%; RD 0.95 pp., 0.78–1.14; RR 12.87, 9.62–17.22), driven by Cluster B (borderline 0.20% vs 0.02%; RD 0.19 pp.; RR 12.34, 6.48–23.51). Surveillance calibration attenuated but did not eliminate Cluster-B excess (e.g., borderline aRR ≈ 3.07).</div></div><div><h3>Conclusions</h3><div>FM is associated with a selective, durable enrichment of Cluster-B PDs—most notably borderline—observable cross-sectionally and as long-term cumulative risk, only partly explained by diagnostic opportunity. Findings support routine PD screening within FM care and motivate mechanistic work on immuno-neuroendocrine and frontolimbic pathways.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112536"},"PeriodicalIF":3.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postsystolic shortening as indicator of regional myocardial dysfunction in patients with bipolar disorder 收缩后缩短作为双相情感障碍患者局部心肌功能障碍的指标。

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-09 DOI: 10.1016/j.jpsychores.2026.112528

Cheng-Yi Hsiao , Tzu-Yu Hsu , Kevin Li-Chun Hsieh , Hsin-Yi Lai , Yen-Kuang Lin , Kuo-Hsuan Chung , Shang-Ying Tsai , Pao-Huan Chen

Background

Patients with bipolar disorder (BD) have a high risk of heart failure. Postsystolic shortening has been proposed as a novel indicator of early cardiac dysfunction. In this exploratory study, postsystolic shortening and its potential association with BD characteristics, cardiometabolic risk factors, and inflammatory markers were evaluated in young adults with BD and mentally healthy individuals.

Methods

This study included 77 and 72 individuals in BD and mentally healthy control groups aged ≤45 years, respectively. The participants underwent two-dimensional speckle-tracking echocardiography, with postsystolic shortening index values calculated from the strain curve by using the following equation: ((maximum strain in cardiac cycle − peak systolic strain)/maximum strain in cardiac cycle) × 100. Cardiometabolic risk factors and inflammatory markers were derived from standard examinations in the hospital.

Results

Postsystolic shortening index values for the myocardial regions supplied by the left anterior descending artery (LAD; Cohen's d = 0.22, p = 0.057), left circumflex artery (LCX; Cohen's d = 0.34, p = 0.017), and right coronary artery (Cohen's d = 0.30, p = 0.003) were greater in patients with BD than in mentally healthy individuals of a similar age. Correlation analysis revealed that cardiometabolic risk factors and inflammatory markers in the BD group were positively correlated with higher postsystolic shortening index values for the LAD and LCX regions.

Conclusion

Postsystolic shortening is a potential indicator of regional myocardial dysfunction in patients with BD. Future replication studies should verify the current findings and investigate the mechanisms underlying the observed associations in this study.

背景：双相情感障碍（BD）患者发生心力衰竭的风险很高。收缩后缩短已被提出作为早期心功能障碍的新指标。在这项探索性研究中，我们评估了年轻成年双相障碍患者和心理健康个体的收缩后缩短及其与双相障碍特征、心脏代谢危险因素和炎症标志物的潜在关联。方法：选取年龄≤45岁的双相障碍组77例，心理健康对照组72例。参与者进行二维斑点跟踪超声心动图，根据应变曲线计算收缩后缩短指数值，公式如下：（（心周期最大应变-收缩峰值应变）/心周期最大应变）× 100。心脏代谢危险因素和炎症标志物来源于医院的标准检查。结果：BD患者的左前降支（LAD, Cohen’s d = 0.22, p = 0.057）、左旋支（LCX, Cohen’s d = 0.34, p = 0.017）、右冠状动脉（Cohen’s d = 0.30, p = 0.003）供血心肌区收缩后缩短指数高于同龄心理健康者。相关分析显示，BD组心脏代谢危险因素和炎症标志物与LAD和LCX区域收缩后缩短指数值升高呈正相关。结论：收缩后缩短是BD患者局部心肌功能障碍的潜在指标。未来的重复性研究应验证当前的发现，并探讨本研究中观察到的相关机制。

{"title":"Postsystolic shortening as indicator of regional myocardial dysfunction in patients with bipolar disorder","authors":"Cheng-Yi Hsiao , Tzu-Yu Hsu , Kevin Li-Chun Hsieh , Hsin-Yi Lai , Yen-Kuang Lin , Kuo-Hsuan Chung , Shang-Ying Tsai , Pao-Huan Chen","doi":"10.1016/j.jpsychores.2026.112528","DOIUrl":"10.1016/j.jpsychores.2026.112528","url":null,"abstract":"<div><h3>Background</h3><div>Patients with bipolar disorder (BD) have a high risk of heart failure. Postsystolic shortening has been proposed as a novel indicator of early cardiac dysfunction. In this exploratory study, postsystolic shortening and its potential association with BD characteristics, cardiometabolic risk factors, and inflammatory markers were evaluated in young adults with BD and mentally healthy individuals.</div></div><div><h3>Methods</h3><div>This study included 77 and 72 individuals in BD and mentally healthy control groups aged ≤45 years, respectively. The participants underwent two-dimensional speckle-tracking echocardiography, with postsystolic shortening index values calculated from the strain curve by using the following equation: ((maximum strain in cardiac cycle − peak systolic strain)/maximum strain in cardiac cycle) × 100. Cardiometabolic risk factors and inflammatory markers were derived from standard examinations in the hospital.</div></div><div><h3>Results</h3><div>Postsystolic shortening index values for the myocardial regions supplied by the left anterior descending artery (LAD; Cohen's <em>d</em> = 0.22, <em>p</em> = 0.057), left circumflex artery (LCX; Cohen's <em>d</em> = 0.34, <em>p</em> = 0.017), and right coronary artery (Cohen's <em>d</em> = 0.30, <em>p</em> = 0.003) were greater in patients with BD than in mentally healthy individuals of a similar age. Correlation analysis revealed that cardiometabolic risk factors and inflammatory markers in the BD group were positively correlated with higher postsystolic shortening index values for the LAD and LCX regions.</div></div><div><h3>Conclusion</h3><div>Postsystolic shortening is a potential indicator of regional myocardial dysfunction in patients with BD. Future replication studies should verify the current findings and investigate the mechanisms underlying the observed associations in this study.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112528"},"PeriodicalIF":3.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosomatic and cognitive outcomes of non-SARS-Cov-2 recent respiratory infections among Chinese adults: A nationwide investigation 中国成年人近期非sars - cov -2呼吸道感染的心身和认知结局：一项全国性调查

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-08 DOI: 10.1016/j.jpsychores.2026.112530

Lei Li , Yucheng Yuan , Wenhao Jiang , Chenguang Jiang , Huijun Duan , Bin Yu , Tao Zou , Zhongyan Li , Peng Xiong , Yingying Yue , Taipeng Sun , Yuqun Zhang , Wei Xu , Yubo Zhang , Xiaoyun Xin , Zhenhua Hou , Changchun Hu , Jue Chen , Juncai Wang , Zhi Xu , Yonggui Yuan

Objectives

While post-COVID symptoms are well-documented, symptoms following non-SARS-CoV-2 recent respiratory tract infections (RRIs) remain understudied. This study aimed to investigate the prevalence, associated factors of symptoms following RRIs.

Methods

A nationwide cross-sectional survey of 61,012 adults was conducted between December 2023 and January 2024. Self-reported RRIs within one month, SARS-CoV-2 infections, infection times and severity of COVID-19 were documented. Psychosomatic symptoms, subjective cognitive and well-being were measured using brief psychosomatic symptom scale (BPSS), brief brain fog scale (BBFS) and 5-item World Health Organization well-being index (WHO-5). Logistic and linear regressions and pathway analyses were used to examine associated factors.

Results

Among 15,715 participants reporting RRIs, 40.8% exhibited psychosomatic symptoms (vs. 25.6% in non-RRI group, FDR-adjusted P < 0.05) and 17.5% reported cognitive symptoms (vs. 9.0%, FDR-adjusted P < 0.05). The most prevalent symptoms included sleep difficulty (18.2%), depression (16.7%), and pain (15.2%). RRIs was more strongly associated with most symptoms than SARS-CoV-2 (OR: 1.41–2.02 vs. 0.88–1.37). Socioeconomic status (OR < 1, FDR-adjusted P < 0.05) and comorbidities (OR > 1, FDR-adjusted P < 0.05) were associated with these symptoms. Participants with both RRIs and previous SARS-CoV-2 infections exhibited increased symptom burdens (psychosomatic: 41.6%; cognitive: 18.0%). Psychosomatic and cognitive symptoms accounted for 71.7% (95% CI: 68.2%–75.4%) and 56.3% (95% CI: 53.1%–59.7%) effects of RRIs on well-being.

Conclusion

RRIs were associated with higher symptom reporting than COVID-19 exacerbated by socioeconomic disparities and comorbidities. Our preliminary findings call for integrated frameworks in practice that managing psychosomatic and cognitive symptoms and socioeconomic factors.

虽然covid后症状有充分的记录，但非sars - cov -2近期呼吸道感染（RRIs）后的症状仍未得到充分研究。本研究旨在调查RRIs后症状的患病率及相关因素。方法：在2023年12月至2024年1月期间，对全国61,012名成年人进行了横断面调查。记录一个月内自我报告的风险风险、SARS-CoV-2感染情况、感染次数和COVID-19严重程度。采用简易心身症状量表（BPSS）、简易脑雾量表（BBFS）和5项世界卫生组织幸福指数（WHO-5）对心身症状、主观认知和幸福感进行测量。采用逻辑回归、线性回归和路径分析来检验相关因素。结果：在15715名报告RRIs的参与者中，40.8%的人表现出心身症状（非rri组为25.6%，fdr校正P 1， fdr校正P）。结论：RRIs与更高的症状报告相关，而社会经济差异和合并症加剧了症状报告。我们的初步研究结果呼吁在实践中建立综合框架，以管理身心和认知症状以及社会经济因素。

{"title":"Psychosomatic and cognitive outcomes of non-SARS-Cov-2 recent respiratory infections among Chinese adults: A nationwide investigation","authors":"Lei Li , Yucheng Yuan , Wenhao Jiang , Chenguang Jiang , Huijun Duan , Bin Yu , Tao Zou , Zhongyan Li , Peng Xiong , Yingying Yue , Taipeng Sun , Yuqun Zhang , Wei Xu , Yubo Zhang , Xiaoyun Xin , Zhenhua Hou , Changchun Hu , Jue Chen , Juncai Wang , Zhi Xu , Yonggui Yuan","doi":"10.1016/j.jpsychores.2026.112530","DOIUrl":"10.1016/j.jpsychores.2026.112530","url":null,"abstract":"<div><h3>Objectives</h3><div>While post-COVID symptoms are well-documented, symptoms following non-SARS-CoV-2 recent respiratory tract infections (RRIs) remain understudied. This study aimed to investigate the prevalence, associated factors of symptoms following RRIs.</div></div><div><h3>Methods</h3><div>A nationwide cross-sectional survey of 61,012 adults was conducted between December 2023 and January 2024. Self-reported RRIs within one month, SARS-CoV-2 infections, infection times and severity of COVID-19 were documented. Psychosomatic symptoms, subjective cognitive and well-being were measured using brief psychosomatic symptom scale (BPSS), brief brain fog scale (BBFS) and 5-item World Health Organization well-being index (WHO-5). Logistic and linear regressions and pathway analyses were used to examine associated factors.</div></div><div><h3>Results</h3><div>Among 15,715 participants reporting RRIs, 40.8% exhibited psychosomatic symptoms (vs. 25.6% in non-RRI group, FDR-adjusted <em>P</em> < 0.05) and 17.5% reported cognitive symptoms (vs. 9.0%, FDR-adjusted <em>P</em> < 0.05). The most prevalent symptoms included sleep difficulty (18.2%), depression (16.7%), and pain (15.2%). RRIs was more strongly associated with most symptoms than SARS-CoV-2 (OR: 1.41–2.02 vs. 0.88–1.37). Socioeconomic status (OR < 1, FDR-adjusted P < 0.05) and comorbidities (OR > 1, FDR-adjusted P < 0.05) were associated with these symptoms. Participants with both RRIs and previous SARS-CoV-2 infections exhibited increased symptom burdens (psychosomatic: 41.6%; cognitive: 18.0%). Psychosomatic and cognitive symptoms accounted for 71.7% (95% CI: 68.2%–75.4%) and 56.3% (95% CI: 53.1%–59.7%) effects of RRIs on well-being.</div></div><div><h3>Conclusion</h3><div>RRIs were associated with higher symptom reporting than COVID-19 exacerbated by socioeconomic disparities and comorbidities. Our preliminary findings call for integrated frameworks in practice that managing psychosomatic and cognitive symptoms and socioeconomic factors.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112530"},"PeriodicalIF":3.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing exercise interventions for depression in stroke patients: A network and dose-response meta-analysis 优化卒中患者抑郁的运动干预：网络和剂量反应荟萃分析。

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-05 DOI: 10.1016/j.jpsychores.2026.112519

Wei Wang , Zhide Liang , Jiao Xiong , Chuanzhi Wang

Objective

Post-stroke depression (PSD) is a common complication following stroke and is associated with increased mortality risk. Evidence suggests that exercise has a beneficial effect on depression. However, the optimal modality and dose of exercise interventions remain unclear. Therefore, this study aims to explore the optimal exercise intervention modality and dose for post-stroke depression.

Methods

We screened six databases, including PubMed, Cochrane Library, Embase, Scopus, Web of Science, and CINAHL, for randomized controlled trials (RCTs) published up to September 2025. The Cochrane risk of bias tool was made available to assess the quality of the literature. A random-effects model was employed to perform a network meta-analysis (NMA).

Results

A total of 29 randomized controlled trials involving 1061 stroke patients were included. Aerobic exercise was the most effective intervention (Hedges' g = −1.14, 95 % CrI: −1.62 to −0.63, k = 6, SUCRA = 0.89). This was followed by qigong exercise (Hedges' g = −0.55, 95 % CrI: −0.99 to −0.10, n = 7, SUCRA = 0.79), flexibility exercises (Hedges' g = −0.55,95 % CrI: −1.00 to −0.10, n = 6 SUCRA = 0.66), Tai Chi (Hedges' g = −0.44,95 % CrI: −0.86 to −0.01, n = 5 SUCRA = 0.48), and resistance training (Hedges' g = −0.29,95 % CrI: −0.72 to 0.16, n = 5 SUCRA = 0.30), whereas yoga (Hedges' g = −0.03, 95 % CrI: −0.79 to 0.72, n = 2, SUCRA = 0.26) did not reach clinical significance (defined as an effect size >0.2 SD). It was also found that the optimal dose range was 500-1100METs-min/week.

Conclusion

Exercise can significantly improve depressive symptoms in patients after stroke. Based on our findings, exercise interventions may be considered a non-pharmacological option for post-stroke depression, as an adjunct to standard care. The optimal dose range appears to be 500–1100 METs-min/week. The effectiveness of different interventions may vary based on patient characteristics, suggesting that clinicians should tailor exercise prescriptions to the individual.

Registration: The review protocol has been registered on PROSPERO(CRD42024601846).

目的：脑卒中后抑郁（PSD）是脑卒中后常见的并发症，与死亡风险增加有关。有证据表明，运动对抑郁症有好处。然而，运动干预的最佳方式和剂量仍不清楚。因此，本研究旨在探讨卒中后抑郁的最佳运动干预方式和剂量。方法：我们筛选了PubMed、Cochrane Library、Embase、Scopus、Web of Science和CINAHL等6个数据库，检索截至2025年9月发表的随机对照试验（RCTs）。使用Cochrane偏倚风险工具评估文献质量。采用随机效应模型进行网络meta分析（NMA）。结果：共纳入29项随机对照试验，涉及1061例脑卒中患者。有氧运动是最有效的干预（Hedges’g = -1.14, 95% CrI: -1.62 ~ -0.63, k = 6, SUCRA = 0.89）。其次是气功锻炼(树篱的g = -0.55, 95%区间:-0.99至-0.10,n = 7, SUCRA = 0.79),柔韧性练习(树篱的g = -0.55, 95%区间:-1.00至-0.10,n = 6 SUCRA = 0.66),太极(树篱的g = -0.44, 95%区间:-0.86至-0.01,n = 5 SUCRA = 0.48)和阻力训练(树篱的g = -0.29, 95%区间:-0.72至0.16,n = 5 SUCRA = 0.30),而瑜伽(树篱的g = -0.03, 95%置信区间:-0.79至0.72,n = 2, SUCRA = 0.26)未达到临床意义（定义为效应量>0.2 SD）。最佳剂量范围为500- 1100met -min/week。结论：运动能显著改善脑卒中后患者的抑郁症状。根据我们的研究结果，运动干预可以作为标准治疗的辅助手段，被认为是卒中后抑郁的一种非药物选择。最佳剂量范围似乎是500- 1100met -min/周。不同干预措施的效果可能会根据患者的特点而有所不同，这表明临床医生应该为个人量身定制运动处方。注册：审查方案已在PROSPERO上注册（CRD42024601846）。

{"title":"Optimizing exercise interventions for depression in stroke patients: A network and dose-response meta-analysis","authors":"Wei Wang , Zhide Liang , Jiao Xiong , Chuanzhi Wang","doi":"10.1016/j.jpsychores.2026.112519","DOIUrl":"10.1016/j.jpsychores.2026.112519","url":null,"abstract":"<div><h3>Objective</h3><div>Post-stroke depression (PSD) is a common complication following stroke and is associated with increased mortality risk. Evidence suggests that exercise has a beneficial effect on depression. However, the optimal modality and dose of exercise interventions remain unclear. Therefore, this study aims to explore the optimal exercise intervention modality and dose for post-stroke depression.</div></div><div><h3>Methods</h3><div>We screened six databases, including PubMed, Cochrane Library, Embase, Scopus, Web of Science, and CINAHL, for randomized controlled trials (RCTs) published up to September 2025. The Cochrane risk of bias tool was made available to assess the quality of the literature. A random-effects model was employed to perform a network meta-analysis (NMA).</div></div><div><h3>Results</h3><div>A total of 29 randomized controlled trials involving 1061 stroke patients were included. Aerobic exercise was the most effective intervention (Hedges' g = −1.14, 95 % CrI: −1.62 to −0.63, k = 6, SUCRA = 0.89). This was followed by qigong exercise (Hedges' g = −0.55, 95 % CrI: −0.99 to −0.10, <em>n</em> = 7, SUCRA = 0.79), flexibility exercises (Hedges' g = −0.55,95 % CrI: −1.00 to −0.10, <em>n</em> = 6 SUCRA = 0.66), Tai Chi (Hedges' g = −0.44,95 % CrI: −0.86 to −0.01, <em>n</em> = 5 SUCRA = 0.48), and resistance training (Hedges' g = −0.29,95 % CrI: −0.72 to 0.16, n = 5 SUCRA = 0.30), whereas yoga (Hedges' g = −0.03, 95 % CrI: −0.79 to 0.72, <em>n</em> = 2, SUCRA = 0.26) did not reach clinical significance (defined as an effect size >0.2 SD). It was also found that the optimal dose range was 500-1100METs-min/week.</div></div><div><h3>Conclusion</h3><div>Exercise can significantly improve depressive symptoms in patients after stroke. Based on our findings, exercise interventions may be considered a non-pharmacological option for post-stroke depression, as an adjunct to standard care. The optimal dose range appears to be 500–1100 METs-min/week. The effectiveness of different interventions may vary based on patient characteristics, suggesting that clinicians should tailor exercise prescriptions to the individual.</div><div><strong>Registration:</strong> The review protocol has been registered on PROSPERO(CRD42024601846).</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112519"},"PeriodicalIF":3.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health and knee osteoarthritis 健康和膝关节骨关节炎

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-05 DOI: 10.1016/j.jpsychores.2026.112518

David Ring

引用次数: 0

Sleep quality and its determinants among family caregivers of patients with cancer in oncologic centers of Northwest Ethiopia: A multicenter cross-sectional study 埃塞俄比亚西北部肿瘤中心癌症患者家庭护理人员的睡眠质量及其决定因素：一项多中心横断面研究

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-03 DOI: 10.1016/j.jpsychores.2025.112515

Fasil Bayafers Tamene , Endalamaw Aschale Mihiretie , Tirsit Ketsela Zeleke , Getachew Yitayew Tarekegn , Tilaye Arega Moges , Akalu Fetene Desalew , Ashenafi Kibret Sendekie , Samuel Agegnew Wondm

Objective

Sleep quality plays a crucial role in overall well-being, and many caregivers of cancer patients report being dissatisfied with their sleep. The aim of this study was to assess sleep quality and its determinants among caregivers of patients with cancer at oncologic centers of Northwest Ethiopia.

Methods

An institution-based, multicenter cross-sectional study was conducted among 412 family caregivers of patients with cancer at oncologic centers in Northwest Ethiopia from August to October 2023. Study participants were enrolled using systematic random sampling. Data entry and analysis were done using EpiDdata version 4.6.0 and Statistical Package for Social Sciences (SPSS) version 26, respectively. A multivariable logistic regression model was used to identify determinants of sleep quality. Variables with a p-value <0.05 at a 95 % Confidence Interval (CI) were defined as statistically significant.

Results

Out of a total of 422 approached participants, 412 eligible caregivers were included in the study. Poor sleep quality was reported among 68.9 % of caregivers. The presence of chronic illness [Adjusted Odds Ratio (AOR) = 2.19, 95 % CI: 1.18, 4.03, P: 0.012], depression [AOR = 3.40, 95 % CI: 2.04, 5.68, P: <0.001], anxiety [AOR = 2.27, 95 % CI: 1.29, 3.99, P: 0.004], and poor social support [AOR = 2.06, 95 % CI: 1.04, 4.06, P: 0.036] were significantly associated with poor sleep quality.

Conclusion

In this study, two-thirds of caregivers were found to have poor sleep quality. Participants with chronic illness, depression, anxiety, and poor social support need prompt screening and follow-up in order to improve sleep quality.

目的：睡眠质量在整体健康中起着至关重要的作用，许多癌症患者的护理人员报告说他们对自己的睡眠不满意。本研究的目的是评估埃塞俄比亚西北部肿瘤中心癌症患者护理人员的睡眠质量及其决定因素。方法：2023年8月至10月，在埃塞俄比亚西北部肿瘤中心对412名癌症患者的家庭护理人员进行了一项以机构为基础的多中心横断面研究。研究参与者采用系统随机抽样方法登记。数据录入和分析分别使用EpiDdata 4.6.0版本和SPSS (Statistical Package for Social Sciences) 26版本。使用多变量逻辑回归模型来确定睡眠质量的决定因素。具有p值的变量结果：在总共422名接近的参与者中，412名符合条件的护理人员被纳入研究。68.9%的护理人员睡眠质量较差。存在慢性疾病[调整优势比(AOR) = 2.19, 95% CI: 1.18, 4.03, P: 0.012]，抑郁[AOR = 3.40, 95% CI: 2.04, 5.68, P:]，结论：本研究中，三分之二的护理人员睡眠质量较差。患有慢性疾病、抑郁、焦虑和缺乏社会支持的参与者需要及时筛查和随访，以改善睡眠质量。

{"title":"Sleep quality and its determinants among family caregivers of patients with cancer in oncologic centers of Northwest Ethiopia: A multicenter cross-sectional study","authors":"Fasil Bayafers Tamene , Endalamaw Aschale Mihiretie , Tirsit Ketsela Zeleke , Getachew Yitayew Tarekegn , Tilaye Arega Moges , Akalu Fetene Desalew , Ashenafi Kibret Sendekie , Samuel Agegnew Wondm","doi":"10.1016/j.jpsychores.2025.112515","DOIUrl":"10.1016/j.jpsychores.2025.112515","url":null,"abstract":"<div><h3>Objective</h3><div>Sleep quality plays a crucial role in overall well-being, and many caregivers of cancer patients report being dissatisfied with their sleep. The aim of this study was to assess sleep quality and its determinants among caregivers of patients with cancer at oncologic centers of Northwest Ethiopia.</div></div><div><h3>Methods</h3><div>An institution-based, multicenter cross-sectional study was conducted among 412 family caregivers of patients with cancer at oncologic centers in Northwest Ethiopia from August to October 2023. Study participants were enrolled using systematic random sampling. Data entry and analysis were done using EpiDdata version 4.6.0 and Statistical Package for Social Sciences (SPSS) version 26, respectively. A multivariable logistic regression model was used to identify determinants of sleep quality. Variables with a <em>p</em>-value <0.05 at a 95 % Confidence Interval (CI) were defined as statistically significant.</div></div><div><h3>Results</h3><div>Out of a total of 422 approached participants, 412 eligible caregivers were included in the study. Poor sleep quality was reported among 68.9 % of caregivers. The presence of chronic illness [Adjusted Odds Ratio (AOR) = 2.19, 95 % CI: 1.18, 4.03, P: 0.012], depression [AOR = 3.40, 95 % CI: 2.04, 5.68, P: <0.001], anxiety [AOR = 2.27, 95 % CI: 1.29, 3.99, P: 0.004], and poor social support [AOR = 2.06, 95 % CI: 1.04, 4.06, P: 0.036] were significantly associated with poor sleep quality.</div></div><div><h3>Conclusion</h3><div>In this study, two-thirds of caregivers were found to have poor sleep quality. Participants with chronic illness, depression, anxiety, and poor social support need prompt screening and follow-up in order to improve sleep quality.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112515"},"PeriodicalIF":3.3,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Further insights in the relationship between religiosity and telomere length 宗教信仰与端粒长度关系的进一步研究

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-03 DOI: 10.1016/j.jpsychores.2026.112517

Juliane Piasseschi de Bernardin Gonçalves , Thais Chile , Vanessa J.R. de Paula , Marcus Zulian Teixeira , Salma Rose Ribeiz , Martin Schalling , Geraldo Busatto Filho , Giancarlo Lucchetti , Homero Vallada

引用次数: 0

Bidirectional relationship between social frailty and mild cognitive impairment in older patients with chronic heart failure: A two-wave longitudinal study 老年慢性心力衰竭患者社会脆弱与轻度认知障碍的双向关系：一项双波纵向研究

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-01-02 DOI: 10.1016/j.jpsychores.2025.112514

Jiurui Wang , Cuicui Xin , Jian Liu , Zeping Yan , Qiuyue Zhang

Background

Although both social frailty (SF) and mild cognitive impairment (MCI) are common comorbidities in older patients with chronic heart failure (CHF) and they interact with each other, their relationship remains unclear.

Objective

The aim of this study was to explore the bidirectional relationship between SF and MCI in older patients with CHF.

Methods

Using the convenience sampling method, 288 older patients with CHF were recruited from China from November 2022 to April 2024 (T₁) and followed up 6-month (T₂) after their discharge from the hospital. Spearman correlation analysis and the cross-lagged panel analysis were used to test the proposed model, adjusted for potential confounding factors.

Results

SF and MCI coexisted in 79 (27.4 %) patients at T₁ moment; however, 84 (29.2 %) patients had coexisting SF and MCI at T₂ moment. The results showed a good model fit: Chi-squared with degrees of freedom

(x^{2}

/

ⅆ f

) = 1.820, goodness of fit index (GFI) = 0.996, comparative fit index (CFI) =0.991, root mean square error of approximation (RMSEA) = 0.068. After controlling the factors influencing SF and MCI at the T1 moment, SF at the T₁ moment could predict MCI at the T₂ moment (effect: – 0.578，95 % CI: −0.694, −0.423); MCI at the T₁ moment could also predict SF at the T₂ moment (effect: - 0.646，95 % CI: −0.801, −0.493).

Conclusions

There was a significant bidirectional relationship between SF and MCI. Interventions targeting either SF or MCI may have mutually beneficial effects.

背景：虽然社会衰弱（SF）和轻度认知障碍（MCI）是老年慢性心力衰竭（CHF）患者常见的合并症，而且两者之间存在相互作用，但它们之间的关系尚不清楚。目的探讨老年CHF患者SF与MCI之间的双向关系。方法采用方便抽样方法，于2022年11月至2024年4月（T1）在中国招募老年CHF患者288例，随访6个月（T2）。采用Spearman相关分析和交叉滞后面板分析对提出的模型进行检验，并对潜在的混杂因素进行了调整。结果T1时刻伴有ssf的患者79例（27.4%）；然而，84例（29.2%）患者在T2时刻同时存在SF和MCI。结果表明，模型拟合良好，自由度卡方（x2/ⅆf） = 1.820，拟合优度指数(GFI) = 0.996，比较拟合指数(CFI) =0.991，近似均方根误差(RMSEA) = 0.068。在控制T1时刻SF和MCI的影响因素后，T1时刻SF可以预测T2时刻MCI（效应：- 0.578,95% CI: - 0.694, - 0.423）；T1时刻的MCI也可以预测T2时刻的SF（效应：- 0.646,95% CI: - 0.801, - 0.493）。结论SF与MCI之间存在显著的双向关系。针对SF或MCI的干预措施可能会产生互利的效果。

{"title":"Bidirectional relationship between social frailty and mild cognitive impairment in older patients with chronic heart failure: A two-wave longitudinal study","authors":"Jiurui Wang , Cuicui Xin , Jian Liu , Zeping Yan , Qiuyue Zhang","doi":"10.1016/j.jpsychores.2025.112514","DOIUrl":"10.1016/j.jpsychores.2025.112514","url":null,"abstract":"<div><h3>Background</h3><div>Although both social frailty (SF) and mild cognitive impairment (MCI) are common comorbidities in older patients with chronic heart failure (CHF) and they interact with each other, their relationship remains unclear.</div></div><div><h3>Objective</h3><div>The aim of this study was to explore the bidirectional relationship between SF and MCI in older patients with CHF.</div></div><div><h3>Methods</h3><div>Using the convenience sampling method, 288 older patients with CHF were recruited from China from November 2022 to April 2024 (T<sub>1</sub>) and followed up 6-month (T<sub>2</sub>) after their discharge from the hospital. Spearman correlation analysis and the cross-lagged panel analysis were used to test the proposed model, adjusted for potential confounding factors.</div></div><div><h3>Results</h3><div>SF and MCI coexisted in 79 (27.4 %) patients at T<sub>1</sub> moment; however, 84 (29.2 %) patients had coexisting SF and MCI at T<sub>2</sub> moment. The results showed a good model fit: Chi-squared with degrees of freedom<span><math><mspace></mspace><mo>(</mo><msup><mi>x</mi><mn>2</mn></msup></math></span>/<span><math><mi>ⅆ</mi><mi>f</mi></math></span>) = 1.820, goodness of fit index (GFI) = 0.996, comparative fit index (CFI) =0.991, root mean square error of approximation (RMSEA) = 0.068. After controlling the factors influencing SF and MCI at the T1 moment, SF at the T<sub>1</sub> moment could predict MCI at the T<sub>2</sub> moment (effect: – 0.578，95 % CI: −0.694, −0.423); MCI at the T<sub>1</sub> moment could also predict SF at the T<sub>2</sub> moment (effect: - 0.646，95 % CI: −0.801, −0.493).</div></div><div><h3>Conclusions</h3><div>There was a significant bidirectional relationship between SF and MCI. Interventions targeting either SF or MCI may have mutually beneficial effects.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112514"},"PeriodicalIF":3.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0