Journal of Psychosomatic Research最新文献

{"title":"Fear of hypoglycemia in parents of children with type 1 diabetes trained for intranasal glucagon use","authors":"Alda Troncone ,&nbsp;Alessia Piscopo ,&nbsp;Angela Zanfardino ,&nbsp;Antonietta Chianese ,&nbsp;Crescenzo Cascella ,&nbsp;Gaetana Affuso ,&nbsp;Anna Borriello ,&nbsp;Stefano Curto ,&nbsp;Assunta Serena Rollato ,&nbsp;Veronica Testa ,&nbsp;Emanuele Miraglia del Giudice ,&nbsp;Lorenza Magliano ,&nbsp;Dario Iafusco","doi":"10.1016/j.jpsychores.2024.111856","DOIUrl":"10.1016/j.jpsychores.2024.111856","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate fear of hypoglycemia (FoH) in parents of children with type 1 diabetes (T1D) before and after undergoing training to learn intranasal (IN) glucagon administration.</p></div><div><h3>Method</h3><p>In this pre-test/post-test uncontrolled study 364 caregivers of patients with T1D (6–18 years) completed questionnaires measuring sociodemographic characteristics, diabetes-related factors (e.g., type of insulin therapy, glycemic control), and parents' trait anxiety. Parents' FoH was assessed at baseline (T0, training) and after nine months (T1). Two repeated-measure mixed analyses of covariance (ANCOVA) compared the FoH at T0 and at T1 and analyzed the moderating roles of anxiety proneness and type of insulin therapy, as well as of anxiety proneness and use of sensor. Age, T1D duration, HbA1c values, and SES were included as covariates.</p></div><div><h3>Results</h3><p>Parental FoH at T1 (M = 1.72; SE = 0.06/M = 1.57; SE = 0.09) was significantly lower than parental FoH at T0 (M = 1.89; SE = 0.06/M = 1.77; SE = 0.09). The group with high trait-anxiety had a higher level of FoH (M = 2.05; SE = 0.08/M = 1.89; SE = 0.12) than the group with low trait-anxiety (M = 1.57; SE = 0.08/M = 1.46; SE = 0.09) at both time points. SES was negatively associated with FoH at T0 (<em>t</em> = −2.87; <em>p =</em> .004/<em>t</em> = −2.87; <em>p</em> = .005). No other significant effects were found.</p></div><div><h3>Conclusions</h3><p>Training and educating parents on IN glucagon use can help them effectively manage hypoglycemic episodes and alleviate the fear that generally accompany such events.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S002239992400268X/pdfft?md5=d395245850f742bd96e83efbbf3bb01b&pid=1-s2.0-S002239992400268X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectionality of LF when the movie makes you sad: Effects of negative emotions on heart rate variability among patients with major depression","authors":"Hayri Can Ozden ,&nbsp;S. Can Gurel ,&nbsp;Necla Ozer ,&nbsp;Basaran Demir","doi":"10.1016/j.jpsychores.2024.111855","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2024.111855","url":null,"abstract":"<div><h3>Objectives</h3><p>Heart rate variability (HRV) reflects the capacity to adapt to internal and environmental changes. Decreased HRV may indicate inadequate adaptive capacity. This study aims to investigate the relationship between the heart and brain's adaptive abilities, both at rest and when negative emotions are stimulated in depression.</p></div><div><h3>Subjects and methods</h3><p>The study included 30 patients (20 female, 10 male) with major depression (mean age = 29.8 ± 7.8) and 30 healthy controls, all of whom had similar characteristics in terms of age and gender, selected through convenience sampling. The patients were drug-free at the time of the assessment. Holter recordings were obtained while subjects watched videos stimulating anger, fear, sadness, and a neutral video, and at rest, HRV parameters were calculated. To control for interindividual variability and account for paired sampling, linear mixed effects models were employed.</p></div><div><h3>Results</h3><p>Watching the ‘sadness video’ led to an increase in low frequency band (LF) [LF change (Control vs depression); Difference:-620.80 df:107 t:-2.093 P:0.039] and LF/high frequency band ratio (LF/HF) [LF/HF change (control vs depression group); Difference:-1.718 df:105 t:-2.374 P:0.020] in the depression group. The video led to a decrease in LF and LF/HF in the controls. Although the differences between the conditions and interactions with the group were significant, the effects were independent of depression severity.</p></div><div><h3>Conclusion</h3><p>In depression, brain's regulatory effect on the heart differed from controls in the sadness condition, possibly due to increased arousal levels in subjects with depression and their inability to suppress sympathetic activity when a state of sadness is stimulated.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141484278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between chronic disease variety and quantity and suicidal ideation: A cross-sectional study of NHANES","authors":"Shijie Guo ,&nbsp;Guangwei Qing ,&nbsp;Guang Yang","doi":"10.1016/j.jpsychores.2024.111854","DOIUrl":"10.1016/j.jpsychores.2024.111854","url":null,"abstract":"<div><h3>Background</h3><p>This cross-sectional study examines the link between chronic diseases and suicidal thoughts in U.S. adults using 2013–2018 National Health and Nutrition Examination Survey (NHANES) data, aiming to identify potential risk factors for suicidal ideation.</p></div><div><h3>Methods</h3><p>Using NHANES data, we analyzed the association between various chronic conditions (hypertension, diabetes, asthma, etc.) and suicidal thoughts, employing logistic regression models adjusted for demographics and lifestyle factors.</p></div><div><h3>Results</h3><p>The analysis of 8891 participants revealed a significant association between suicidal thoughts and chronic diseases such as liver disease, diabetes, and asthma. The risk of suicidal ideation is higher with the number of chronic conditions.</p></div><div><h3>Conclusion</h3><p>Our findings suggest a strong link between the presence and number of chronic diseases and the risk of suicidal thoughts, emphasizing the importance of integrated care approaches that address both physical and mental health needs.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “beyond physical pain: A large-scale cohort study on endometriosis trends and mental health correlates”","authors":"Maria I. Zervou ,&nbsp;George N. Goulielmos","doi":"10.1016/j.jpsychores.2024.111853","DOIUrl":"10.1016/j.jpsychores.2024.111853","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of COVID-19 vaccination and anxiety symptoms: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort longitudinal study","authors":"Gabrielle Virgili-Gervais ,&nbsp;Richard S. Henry ,&nbsp;Linda Kwakkenbos ,&nbsp;Marie-Eve Carrier ,&nbsp;Scott Patten ,&nbsp;Susan J. Bartlett ,&nbsp;Luc Mouthon ,&nbsp;John Varga ,&nbsp;Andrea Benedetti ,&nbsp;Brett D. Thombs ,&nbsp;the SPIN COVID-19 Patient Advisory Team ,&nbsp;SPIN Investigators","doi":"10.1016/j.jpsychores.2024.111852","DOIUrl":"10.1016/j.jpsychores.2024.111852","url":null,"abstract":"<div><h3>Objective</h3><p>Symptoms of anxiety increased early in the COVID-19 pandemic among people with systemic sclerosis (SSc) then returned to pre-pandemic levels, but this was an aggregate finding and did not evaluate whether vaccination may have contributed to reduced anxiety symptom levels. We investigated whether being vaccinated for COVID-19 was associated with reduced anxiety symptoms among people with SSc.</p></div><div><h3>Methods</h3><p>The longitudinal Scleroderma Patient-centered Intervention Network (SPIN) COVID-19 Cohort was launched in April 2020 and included participants from the ongoing SPIN Cohort and external enrollees. Participants completed measures bi-weekly through July 2020, then every 4 weeks afterwards through August 2022 (32 assessments). We used linear mixed models to evaluate longitudinal trends of PROMIS Anxiety 4a v1.0 anxiety domain scores and their association with vaccination.</p></div><div><h3>Results</h3><p>Among 517 participants included in analyses, 489 (95%) were vaccinated by September 2021, and no participants were vaccinated subsequently. Except for briefly at the beginning, when few had received a vaccine, and end, when only 28 participants remained unvaccinated, anxiety symptom trajectories were largely overlapping. Participants who were never vaccinated had higher anxiety symptoms by August 2022, but there were no other differences, and receiving a vaccination did not appear to change anxiety symptom trajectories meaningfully.</p></div><div><h3>Conclusion</h3><p>Vaccination did not appear to influence changes in anxiety symptoms among vulnerable people with SSc during the COVID-19 pandemic. This may be due to people restricting their behavior when they were unvaccinated and returning to more normal social engagement once vaccinated to maintain a steady level of anxiety symptoms.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924002642/pdfft?md5=d2de6788441977c5c1c2d61927c2507a&pid=1-s2.0-S0022399924002642-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food insecurity and mobility difficulty in middle-aged and older adults: The importance of bio-psychosocial factors","authors":"Razak M. Gyasi ,&nbsp;Hubert Bimpeh Asiedu ,&nbsp;Lawrencia Pokuah Siaw ,&nbsp;Emmanuel Nyaaba ,&nbsp;Emmanuel Affum-Osei ,&nbsp;Richard Bruce Lamptey ,&nbsp;Faith Muhonja ,&nbsp;Dominic Degraft Arthur ,&nbsp;Edward Asamoah ,&nbsp;Michael Nimoh ,&nbsp;Samuel Adu-Gyamfi","doi":"10.1016/j.jpsychores.2024.111849","DOIUrl":"10.1016/j.jpsychores.2024.111849","url":null,"abstract":"<div><h3>Objective</h3><p>Food insecurity has been associated with mobility difficulty (MD) in old age. However, there is a scarcity of research on this topic from low- and middle-income countries, while the bio-psychological factors underlying this association are largely unknown. We investigated the food insecurity-MD link in Ghana and explored how sleep, anxiety, loneliness, and physical activity (PA) mediate the association.</p></div><div><h3>Methods</h3><p>Community-based, representative cross-sectional data from the Aging, Health, Well-being, and Health-seeking Behavior Study were analyzed (<em>N</em> = 1201; <em>M</em>_age = 66.5; women = 63%). MD was assessed with items from the SF-36 of the Medical Outcomes Study. We assessed food insecurity with items on hunger and breakfast-skipping frequency due to lack of food and resources. Adjusted OLS and mediation models via bootstrapping technique evaluated the associations.</p></div><div><h3>Results</h3><p>Results revealed the expected association between food insecurity and MD, such that greater food insecurity was significantly and positively associated with MD across paths (from β = 0.33 to β = 0.42, <em>p</em> &lt; .001). Analyses of indirect effects showed that sleep problems (27.8%), anxiety (15.5%), loneliness (17.5%), and PA (18.0%) mediated the association between food insecurity and MD. Cross-level interactions revealed that food insecurity significantly modified the link between each mediator and MD.</p></div><div><h3>Conclusions</h3><p>Our data provide novel evidence that bio-psychological mechanisms may underlie the food insecurity-MD link and should, therefore, be considered relevant targets for interventions to prevent/manage MD in later life.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind over chronic pain: A meta-analysis of cognitive restructuring in chronically ill adults","authors":"Sebastian Pintea ,&nbsp;Paula Maier","doi":"10.1016/j.jpsychores.2024.111837","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2024.111837","url":null,"abstract":"<div><h3>Objective</h3><p>This meta-analysis synthesizes research on the impact of cognitive restructuring on chronic pain intensity, aiming to integrate diverse methodologies and findings while evaluating potential moderators.</p></div><div><h3>Methods</h3><p>Following PRISMA guidelines, we systematically searched multiple databases (PubMed, Web of Science, JSTOR, Sage, Social Science Research Network, PsycArticles, ScienceDirect, and Education Resources Information Center) until July 2023. Studies involving adults (≥18 years) diagnosed with chronic conditions who underwent cognitive restructuring to reduce chronic pain intensity, were included. Eligible studies compared this intervention with a control group. We excluded studies incorporating cognitive restructuring within broader interventions, lacking statistical data, or not written in English. Study quality was assessed using the Cochrane Risk of Bias tool (RoB 2).</p></div><div><h3>Results</h3><p>After reviewing 18,312 studies, we selected 11 studies published between 1991 and 2022, involving 693 participants with chronic conditions. A significant large overall effect size was found (<em>d</em> = 0.94, 95% CI 0.48 to 1.40). Moderation analyses revealed significant differences based on sex and study quality, with effects less pronounced among females and more substantial in higher-quality studies.</p></div><div><h3>Conclusion</h3><p>Despite limitations such as statistical instability due to a small number of studies in certain moderator categories and methodological variability, this meta-analysis highlights the robust effects of cognitive restructuring on chronic pain intensity. The findings are valuable for guiding power calculations and future research expectations. Clinically, these results support the significant effect of cognitive restructuring in both individual and group settings, regardless of age, particularly when facilitated by teams that include psychologists.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141487546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the effect of cognitive behaviour therapy for chronic fatigue syndrome (ME/CFS) moderated by the presence of comorbid depressive symptoms? A meta-analysis of three treatment delivery formats","authors":"T.A. Kuut ,&nbsp;L.M. Buffart ,&nbsp;A.M.J. Braamse ,&nbsp;F. Müller ,&nbsp;H. Knoop","doi":"10.1016/j.jpsychores.2024.111850","DOIUrl":"https://doi.org/10.1016/j.jpsychores.2024.111850","url":null,"abstract":"<div><h3>Objective</h3><p>Cognitive behaviour therapy (CBT) for fatigue in chronic fatigue syndrome (ME/CFS) leads to a significant reduction of fatigue and disability and is available in different treatment delivery formats, i.e. internet-based, individual face-to-face and group face-to-face. The aim of this study was to investigate whether moderation of the effects of CBT by clinically relevant depressive symptoms varies between CBT delivery formats.</p></div><div><h3>Methods</h3><p>Data from six randomised controlled trials (<em>n</em> = 1084 patients) were pooled. Moderation of clinically relevant depressive symptoms (Brief Depression Inventory for Primary Care) in different treatment formats on fatigue severity (Checklist Individual Strength, subscale fatigue severity), functional impairment (Sickness Impact Profile-8) and physical functioning (Short Form-36, subscale physical functioning) was investigated using linear mixed model analyses and interaction tests. Differences in percentages of patients no longer severely fatigued post-CBT were studied by calculating relative risks.</p></div><div><h3>Results</h3><p>The moderator effect of depressive symptoms on fatigue severity varied by delivery format. In internet-based CBT, ME/CFS patients with depressive symptoms showed less reduction in fatigue, and were more often still severely fatigued post-treatment than patients without depressive symptoms. In individual and group face-to-face CBT, no significant difference in treatment effect on fatigue severity was found between patients with and without depressive symptoms. No moderation was found for the other outcomes.</p></div><div><h3>Conclusion</h3><p>In internet-based CBT, ME/CFS patients with comorbid depressive symptoms benefit less, making face-to-face CBT currently the first-choice delivery format for these patients. Internet-based CBT should be further developed to improve its effectiveness for ME/CFS patients with depressive symptoms.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924002629/pdfft?md5=87cb4adbe684b9bfbc48b588571f0e45&pid=1-s2.0-S0022399924002629-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatic symptom disorder symptoms in individuals at risk for heart failure: A cluster analysis with cross-sectional data from a population-based cohort study","authors":"Caroline Clifford ,&nbsp;Raphael Twerenbold ,&nbsp;Friederike Hartel ,&nbsp;Bernd Löwe ,&nbsp;Sebastian Kohlmann","doi":"10.1016/j.jpsychores.2024.111848","DOIUrl":"10.1016/j.jpsychores.2024.111848","url":null,"abstract":"<div><h3>Objective</h3><p>Identifying whether experienced symptom burden in individuals with medical predisposition indicates somatic symptom disorder (SSD) is challenging, given the high overlap in the phenomenology of symptoms within this group. This study aimed to enhance understanding SSD in individuals at risk for heart failure.</p></div><div><h3>Subjects and methods</h3><p>Cross-sectional data from the Hamburg City Health Study was analyzed including randomly selected individuals from the general population of Hamburg, Germany recruited from February 2016 to November 2018. SSD symptoms assessed with the Somatic Symptom Scale-8 and the Somatic Symptom Disorder-12 scale were categorized by applying cluster analysis including 412 individuals having at least 5% risk for heart failure-related hospitalization within the next ten years. Clusters were compared for biomedical and psychological factors using ANOVA and chi-square tests. Linear regressions, adjusting for sociodemographic, biomedical, and psychological factors, explored associations between clusters with general practitioner visits and quality of life.</p></div><div><h3>Results</h3><p>Three clusters emerged: none (<em>n</em> = 215; 43% female), moderate (<em>n</em> = 151; 48% female), and severe (<em>n</em> = 46; 54% female) SSD symptom burden. The SSS-8 mean sum scores were 3.4 (<em>SD</em> = 2.7) for no, 6.4 (<em>SD</em> = 3.4) for moderate, and 12.4 (<em>SD</em> = 3.7) for severe SSD symptom burden. The SSD-12 mean sum scores were 3.1 (<em>SD</em> = 2.6) for no, 12.2 (<em>SD</em> = 4.2) for moderate, and 23.5 (<em>SD</em> = 6.7) for severe SSD symptom burden. Higher SSD symptom burden correlated with biomedical factors (having diabetes: <em>p</em> = .005 and dyspnea: <em>p</em> ≤ .001) and increased psychological burden (depression severity: <em>p</em> ≤ .001; anxiety severity: <em>p</em> ≤ .001), irrespective of heart failure risk (<em>p</em> = .202). Increased SSD symptoms were associated with more general practitioner visits (β = 0.172; <em>p</em> = .002) and decreased physical quality of life (β = −0.417; <em>p</em> ≤ .001).</p></div><div><h3>Conclusion</h3><p>Biomedical factors appear relevant in characterizing individuals at risk for heart failure, while psychological factors affect SSD symptom experience. Understanding SSD symptom diversity and addressing subgroup needs could prove beneficial.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924002605/pdfft?md5=394aaf7d962afa5064deed71ecf709de&pid=1-s2.0-S0022399924002605-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relations of optimism and purpose in life to immune markers in aging","authors":"Hayami K. Koga ,&nbsp;Francine Grodstein ,&nbsp;David R. Williams ,&nbsp;Dawn L. Demeo ,&nbsp;Laura D. Kubzansky","doi":"10.1016/j.jpsychores.2024.111851","DOIUrl":"10.1016/j.jpsychores.2024.111851","url":null,"abstract":"<div><h3>Objective</h3><p>Optimism and purpose in life are associated with improved health outcomes. More information is needed on biological mechanisms, including immunosenescence. We investigated if psychological well-being is associated with healthier immunosenescence-related measures including naïve and terminally differentiated CD4⁺ and CD8⁺ T cell percentages, CD4⁺:CD8⁺, and cytomegalovirus (CMV) IgG response.</p></div><div><h3>Methods</h3><p>Participants were adults over age 50 from the Health and Retirement Study. Optimism was measured using the Life Orientation Test Revised. Purpose in life was assessed using the subscale from the Ryff psychological well-being measure. We examined the cross-sectional associations of optimism and purpose in life with measures of T cell subsets using linear regression and with CMV IgG using ordered logit regression, controlling for potential confounding factors.</p></div><div><h3>Results</h3><p>The final analytic sample ranged from 7250 to 7870. After adjusting for sociodemographic factors, a 1-SD increment in optimism was associated with the percentage of naïve CD4⁺ T cells increasing by 0.6 (95%CI 0.2%, 1.0%). A 1-SD increment in purpose in life was associated with the percentage of naïve CD4⁺ T cells increasing by 0.9 (95%CI 0.5%, 1.3%) after adjusting for sociodemographic factors and the association was maintained after further adjustments for health conditions, depression, and health behaviors. For naïve CD8⁺ T cell percentages, CD4:CD8 ratios, and CMV IgG antibodies, associations were seen only in models that adjusted for age. No significant associations were seen in any models for the terminally differentiated CD4⁺ and CD8⁺ T cells.</p></div><div><h3>Conclusions</h3><p>We found associations of optimism and purpose in life with naïve CD4⁺ T cell percentages.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}