Journal of Psychosomatic Research最新文献_第2页

Factors associated with psychological distress in patients with amyotrophic lateral sclerosis: A retrospective medical records study 肌萎缩性脊髓侧索硬化症患者心理困扰的相关因素：回顾性病历研究

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-03 DOI: 10.1016/j.jpsychores.2024.111915

Objective

Although psychological distress is a prevalent issue among patients with amyotrophic lateral sclerosis (ALS) and can impact survival, the risk factors contributing to this distress remain insufficiently understood.

Methods

Patients with ALS who completed the Profile of Mood States (POMS) between June 2017 and March 2022 were included. Participants with moderate to severe cognitive decline were excluded, resulting in the recruitment of 121 patients. The associations between POMS profiles and clinical characteristics were analyzed. Physical motor symptoms were evaluated using the Revised ALS Functional Rating Scale (ALSFRS-R) for objective measurement and the 40-item ALS Assessment Questionnaire (ALSAQ-40) for subjective assessment.

Results

Our model, employing the ALSFRS-R, revealed significant factors associated with overall psychological distress, as assessed by the POMS, including upper limb symptoms, the presence of sleep apnea syndrome, older age at onset, and male sex, with an inverse association with tracheostomy. The POMS subscale scores revealed that anger and depression were significantly associated with upper limb symptoms. The second model, which employed subjective scales, yielded similar results, reinforcing the robustness of our findings. Moreover, subjective bulbar symptoms on the ALSAQ-40 were significantly associated with psychological distress, particularly in female patients.

Conclusion

This study identified the main clinical characteristics significantly associated with psychological distress in patients with ALS. Our findings may be useful in developing individualized psychological management strategies for these patients.

目的虽然心理困扰是肌萎缩侧索硬化症（ALS）患者中普遍存在的问题，并会影响患者的生存，但导致这种困扰的风险因素仍未得到充分了解。方法纳入在2017年6月至2022年3月期间完成情绪状态档案（POMS）的ALS患者。排除了认知能力中度至重度下降的参与者，最终招募了121名患者。分析了 POMS 资料与临床特征之间的关联。结果我们采用ALSFRS-R建立的模型揭示了与POMS评估的总体心理压力相关的重要因素，包括上肢症状、存在睡眠呼吸暂停综合征、发病年龄较大和男性，并且与气管切开术呈反向关系。POMS 分量表显示，愤怒和抑郁与上肢症状有显著相关性。采用主观量表的第二个模型也得出了类似的结果，这加强了我们研究结果的稳健性。此外，ALSAQ-40 的主观球部症状与心理困扰有显著相关性，尤其是女性患者。我们的研究结果可能有助于为这些患者制定个性化的心理管理策略。

{"title":"Factors associated with psychological distress in patients with amyotrophic lateral sclerosis: A retrospective medical records study","authors":"","doi":"10.1016/j.jpsychores.2024.111915","DOIUrl":"10.1016/j.jpsychores.2024.111915","url":null,"abstract":"<div><h3>Objective</h3><p>Although psychological distress is a prevalent issue among patients with amyotrophic lateral sclerosis (ALS) and can impact survival, the risk factors contributing to this distress remain insufficiently understood.</p></div><div><h3>Methods</h3><p>Patients with ALS who completed the Profile of Mood States (POMS) between June 2017 and March 2022 were included. Participants with moderate to severe cognitive decline were excluded, resulting in the recruitment of 121 patients. The associations between POMS profiles and clinical characteristics were analyzed. Physical motor symptoms were evaluated using the Revised ALS Functional Rating Scale (ALSFRS-R) for objective measurement and the 40-item ALS Assessment Questionnaire (ALSAQ-40) for subjective assessment.</p></div><div><h3>Results</h3><p>Our model, employing the ALSFRS-R, revealed significant factors associated with overall psychological distress, as assessed by the POMS, including upper limb symptoms, the presence of sleep apnea syndrome, older age at onset, and male sex, with an inverse association with tracheostomy. The POMS subscale scores revealed that anger and depression were significantly associated with upper limb symptoms. The second model, which employed subjective scales, yielded similar results, reinforcing the robustness of our findings. Moreover, subjective bulbar symptoms on the ALSAQ-40 were significantly associated with psychological distress, particularly in female patients.</p></div><div><h3>Conclusion</h3><p>This study identified the main clinical characteristics significantly associated with psychological distress in patients with ALS. Our findings may be useful in developing individualized psychological management strategies for these patients.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing network structures of depressive and anxiety symptoms between demographically-matched heart disease and heart disease free samples using propensity score matching: Findings from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) 利用倾向得分匹配法比较与人口统计学匹配的心脏病样本和无心脏病样本的抑郁症状和焦虑症状网络结构：中国健康长寿纵向调查（CLHLS）的发现

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-02 DOI: 10.1016/j.jpsychores.2024.111910

Background

Older adults with heart disease often experience higher rates of comorbid anxiety and depression. This study examined depression and anxiety network structures among older adults with heart disease and their heart disease free peers.

Methods

Network analyses of secondary cross-sectional data from the 2017 to 2018 wave of CLHLS were used to construct groups of older adults with and without heart disease using propensity score matching. Depression and anxiety symptoms were assessed using Center for Epidemiological Studies Depression Scale and Generalized Anxiety Disorder Scale, respectively. Central symptoms and bridge symptoms were identified using expected influence.

Results

1689 older adults with heart disease and matched control sample of 1689 older adults without heart disease were included. The prevalence and severity of depression and anxiety were significantly higher in older adults with heart disease compared to the control group. There was no significant difference in overall structures of depression and anxiety network models between two the groups. Key central symptoms and bridge symptoms within these groups were highly similar; GAD 2 “Uncontrollable worrying” and GAD 4 “Trouble relaxing” were identified as the most central symptoms, while GAD 1 “Nervousness” and CESD 1 “Feeling bothered” were identified as key bridge symptoms across both network models.

Conclusion

Depression and anxiety are more prevalent in older adults with heart disease than demographically-matched heart disease free controls. However, network structures of these symptoms do not differ between two groups. Accordingly, depression and anxiety psychosocial interventions developed for older adults without heart disease may also benefit older adults with heart disease.

背景患有心脏病的老年人往往合并有较高的焦虑和抑郁。本研究考察了患有心脏病的老年人及其无心脏病的同龄人之间的抑郁和焦虑网络结构。方法通过对2017年至2018年波CLHLS的二级横截面数据进行网络分析，使用倾向得分匹配法构建患有和未患有心脏病的老年人群体。分别使用流行病学研究中心抑郁量表和广泛性焦虑症量表评估抑郁和焦虑症状。结果 1689 名患有心脏病的老年人和 1689 名无心脏病的老年人组成了匹配对照样本。与对照组相比，患有心脏病的老年人抑郁和焦虑的发生率和严重程度明显更高。两组抑郁和焦虑网络模型的整体结构没有明显差异。两组中的关键中心症状和桥接症状非常相似；GAD 2 "无法控制的担忧 "和 GAD 4 "难以放松 "被认为是最中心的症状，而 GAD 1 "紧张 "和 CESD 1 "感到困扰 "被认为是两个网络模型中的关键桥接症状。然而，这些症状的网络结构在两组之间并无差异。因此，为无心脏病的老年人制定的抑郁和焦虑心理干预措施也可能有益于患有心脏病的老年人。

{"title":"Comparing network structures of depressive and anxiety symptoms between demographically-matched heart disease and heart disease free samples using propensity score matching: Findings from the Chinese Longitudinal Healthy Longevity Survey (CLHLS)","authors":"","doi":"10.1016/j.jpsychores.2024.111910","DOIUrl":"10.1016/j.jpsychores.2024.111910","url":null,"abstract":"<div><h3>Background</h3><p>Older adults with heart disease often experience higher rates of comorbid anxiety and depression. This study examined depression and anxiety network structures among older adults with heart disease and their heart disease free peers.</p></div><div><h3>Methods</h3><p>Network analyses of secondary cross-sectional data from the 2017 to 2018 wave of CLHLS were used to construct groups of older adults with and without heart disease using propensity score matching. Depression and anxiety symptoms were assessed using Center for Epidemiological Studies Depression Scale and Generalized Anxiety Disorder Scale, respectively. Central symptoms and bridge symptoms were identified using expected influence.</p></div><div><h3>Results</h3><p>1689 older adults with heart disease and matched control sample of 1689 older adults without heart disease were included. The prevalence and severity of depression and anxiety were significantly higher in older adults with heart disease compared to the control group. There was no significant difference in overall structures of depression and anxiety network models between two the groups. Key central symptoms and bridge symptoms within these groups were highly similar; GAD 2 “Uncontrollable worrying” and GAD 4 “Trouble relaxing” were identified as the most central symptoms, while GAD 1 “Nervousness” and CESD 1 “Feeling bothered” were identified as key bridge symptoms across both network models.</p></div><div><h3>Conclusion</h3><p>Depression and anxiety are more prevalent in older adults with heart disease than demographically-matched heart disease free controls. However, network structures of these symptoms do not differ between two groups. Accordingly, depression and anxiety psychosocial interventions developed for older adults without heart disease may also benefit older adults with heart disease.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor imagery ability in patients with functional dystonia 功能性肌张力障碍患者的运动想象能力

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-01 DOI: 10.1016/j.jpsychores.2024.111911

Introduction

Motor imagery (MI) involves recreating a movement mentally without physically performing the movement itself. MI has a positive impact on motor performance, motor learning and neural plasticity. We analysed the connection between motor imagination and altered movement execution in individuals with dystonia, a complex sensorimotor disorder. The aim of our study was to examine MI ability in patients with functional dystonia (FD) in comparison to organic dystonia (OD).

Methods

Our case-control study involved 46 patients, 22 with FD and 24 with OD. The assessment consisted of specific questionnaire and standardized motor, cognitive and psychiatric scales. The KVIQ-20 was used to test MI in each patient.

Results

Patients with FD scored lower on both global visual and kinaesthetic scales of the KVIQ-20 exam compared to patients with OD (63.1 ± 18.5 vs. 73.7 ± 13.2, and 54.9 ± 21.9 vs. 68.8 ± 18.2, respectively). Patients with FD also exhibited visual and/or kinaesthetic MI impairment in different body segments. The internal perspective when imagining movements was preferred in both patients with FD and OD.

Conclusion

FD patients showed global dysfunction of visual and kinaesthetic MI abilities. Techniques for MI improvements might have a potential role in dystonia rehabilitation.

导言运动想象（MI）是指在不实际做动作的情况下，在头脑中再现动作。运动想象对运动表现、运动学习和神经可塑性有积极影响。我们分析了肌张力障碍（一种复杂的感觉运动障碍）患者的运动想象与运动执行改变之间的联系。我们的研究旨在对功能性肌张力障碍（FD）患者的运动想象能力与器质性肌张力障碍（OD）患者的运动想象能力进行比较。评估包括特定问卷以及标准化的运动、认知和精神量表。结果与OD患者相比，FD患者在KVIQ-20检查的整体视觉和运动感觉量表上的得分都较低（分别为63.1 ± 18.5 vs. 73.7 ± 13.2和54.9 ± 21.9 vs. 68.8 ± 18.2）。FD患者在不同的身体部位也表现出视觉和/或运动神经元损伤。FD和OD患者在想象动作时都更倾向于内部视角。改善肌张力障碍的技术可能在肌张力障碍康复中发挥潜在作用。

{"title":"Motor imagery ability in patients with functional dystonia","authors":"","doi":"10.1016/j.jpsychores.2024.111911","DOIUrl":"10.1016/j.jpsychores.2024.111911","url":null,"abstract":"<div><h3>Introduction</h3><p>Motor imagery (MI) involves recreating a movement mentally without physically performing the movement itself. MI has a positive impact on motor performance, motor learning and neural plasticity. We analysed the connection between motor imagination and altered movement execution in individuals with dystonia, a complex sensorimotor disorder. The aim of our study was to examine MI ability in patients with functional dystonia (FD) in comparison to organic dystonia (OD).</p></div><div><h3>Methods</h3><p>Our case-control study involved 46 patients, 22 with FD and 24 with OD. The assessment consisted of specific questionnaire and standardized motor, cognitive and psychiatric scales. The KVIQ-20 was used to test MI in each patient.</p></div><div><h3>Results</h3><p>Patients with FD scored lower on both global visual and kinaesthetic scales of the KVIQ-20 exam compared to patients with OD (63.1 ± 18.5 vs. 73.7 ± 13.2, and 54.9 ± 21.9 vs. 68.8 ± 18.2, respectively). Patients with FD also exhibited visual and/or kinaesthetic MI impairment in different body segments. The internal perspective when imagining movements was preferred in both patients with FD and OD.</p></div><div><h3>Conclusion</h3><p>FD patients showed global dysfunction of visual and kinaesthetic MI abilities. Techniques for MI improvements might have a potential role in dystonia rehabilitation.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mediational role of hearing acuity in the association between personality and memory: Evidence from the health and retirement study and the English Longitudinal Study of Ageing 听觉敏锐度在人格与记忆力之间的中介作用：来自健康与退休研究和英国老龄化纵向研究的证据

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-01 DOI: 10.1016/j.jpsychores.2024.111912

Objectives

Personality traits (i.e., the enduring patterns of thoughts, feelings, and behaviors) are associated with cognition across adulthood. There is interest in identifying potential mechanisms to explain this association, but none has focused on sensory function. Therefore, the present study examined whether an objective measure of hearing acuity mediates the association between personality and memory.

Methods

Participants were from the Health and Retirement Study (HRS, N = 5497, 60 % women, Mean age = 65.66, SD = 9.00) and the English Longitudinal Study of Ageing (ELSA, N = 4706, 57 % women, Mean age = 64.47, SD = 7.59). In the HRS, participants had data on personality and demographic variables in 2012/2014, hearing acuity in 2016/2018, and memory in 2020. In ELSA, participants had data on personality and demographic variables measured in 2010/2011, hearing acuity in 2014/2015, and memory in 2018/2019.

Results

In both HRS and ELSA, higher hearing acuity partially mediated the association between lower neuroticism (4 % and 5 % proportion effect mediated), higher conscientiousness (6 % and 15 %) and higher openness (3 % and 7 %) and better memory performances at follow-up.

Conclusions

The present study provides novel evidence that hearing acuity mediates the association between personality and cognition.

目的人格特质（即思想、情感和行为的持久模式）与整个成年期的认知相关。人们有兴趣找出解释这种关联的潜在机制，但没有一项研究关注感官功能。因此，本研究考察了听觉敏锐度的客观测量是否会介导性格与记忆之间的关联。方法参与者来自健康与退休研究（HRS，人数=5497，60%为女性，平均年龄=65.66，SD=9.00）和英国老龄化纵向研究（ELSA，人数=4706，57%为女性，平均年龄=64.47，SD=7.59）。在 HRS 中，参与者拥有 2012/2014 年的性格和人口统计学变量数据、2016/2018 年的听力敏锐度数据和 2020 年的记忆力数据。结果在HRS和ELSA中，较高的听力敏锐度部分介导了较低的神经质（介导效应比例分别为4%和5%）、较高的自觉性（6%和15%）和较高的开放性（3%和7%）与随访时较好的记忆表现之间的关联。

{"title":"The mediational role of hearing acuity in the association between personality and memory: Evidence from the health and retirement study and the English Longitudinal Study of Ageing","authors":"","doi":"10.1016/j.jpsychores.2024.111912","DOIUrl":"10.1016/j.jpsychores.2024.111912","url":null,"abstract":"<div><h3>Objectives</h3><p>Personality traits (i.e., the enduring patterns of thoughts, feelings, and behaviors) are associated with cognition across adulthood. There is interest in identifying potential mechanisms to explain this association, but none has focused on sensory function. Therefore, the present study examined whether an objective measure of hearing acuity mediates the association between personality and memory.</p></div><div><h3>Methods</h3><p>Participants were from the Health and Retirement Study (HRS, <em>N</em> = 5497, 60 % women, Mean age = 65.66, SD = 9.00) and the English Longitudinal Study of Ageing (ELSA, <em>N</em> = 4706, 57 % women, Mean age = 64.47, SD = 7.59). In the HRS, participants had data on personality and demographic variables in 2012/2014, hearing acuity in 2016/2018, and memory in 2020. In ELSA, participants had data on personality and demographic variables measured in 2010/2011, hearing acuity in 2014/2015, and memory in 2018/2019.</p></div><div><h3>Results</h3><p>In both HRS and ELSA, higher hearing acuity partially mediated the association between lower neuroticism (4 % and 5 % proportion effect mediated), higher conscientiousness (6 % and 15 %) and higher openness (3 % and 7 %) and better memory performances at follow-up.</p></div><div><h3>Conclusions</h3><p>The present study provides novel evidence that hearing acuity mediates the association between personality and cognition.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of genetic variations in the serotonergic system on symptom severity and clinical outcome in functional neurological disorders 血清素能系统的基因变异对功能性神经紊乱的症状严重程度和临床结果的影响

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-08-30 DOI: 10.1016/j.jpsychores.2024.111909

Objective

We studied gene-environment, as well as gene-gene interaction to elucidate their effects on symptom severity and predict clinical outcomes in functional neurological disorders (FND).

Methods

Eighty-five patients with mixed FND were genotyped for ten single-nucleotide polymorphisms (SNP) from seven different stress-related genes. We tested cross-sectionally the association between genotype and the symptomatology of FND (symptom severity assessed with the examiner-based clinical global impression score [CGI] and age of onset). Clinical outcome was assessed in 52 patients who participated in a follow-up clinical visit after eight months (following their individual therapies as usual). We tested longitudinally the association between genotype and clinical outcome in FND. We examined the contribution of each SNP and their interaction between them to FND symptomatology and outcome.

Results

We identified a nominal association between tryptophan hydroxylase 1 (TPH1) rs1800532 and symptom severity (CGI₁) in FND under a codominant model (T/T: ß_T/T = 2.31, se_T/T = 0.57; G/T: ß_G/T = -0.18, se_G/T = 0.29, P = 0.035), with minor allele (T) carriers presenting more severe symptoms. An association was identified between TPH1 and clinical outcome, suggesting that major allele (G) carriers were more likely to have an improved outcome under a codominant model (G/T: OR_G/T = 0.18, CI_G/T = [0.02–1.34]; T/T: OR_T/T = 2.08, CI_T/T = [0.30–14.53], P = 0.041). Our analyses suggested a significant gene-gene interaction for TPH2 (rs4570625) and OXTR (rs2254298) on symptom severity, and a significant gene-gene interaction for TPH1, TPH2 and BDNF (rs1491850) on clinical outcome.

Conclusion

FND might arise from a complex interplay between individual predisposing risk genes involved in the serotonergic pathway and their gene-gene interactions.

目的我们研究了基因-环境以及基因-基因之间的相互作用，以阐明它们对功能性神经紊乱（FND）症状严重程度的影响并预测其临床结局。方法我们对 85 名混合型 FND 患者进行了基因分型，检测了来自 7 个不同压力相关基因的 10 个单核苷酸多态性（SNP）。我们横向测试了基因型与 FND 症状之间的关联（症状严重程度通过基于检查者的临床总体印象评分 [CGI] 和发病年龄进行评估）。我们对 52 名患者的临床疗效进行了评估，这些患者在 8 个月后参加了临床随访（如常接受个人治疗）。我们对 FND 基因型与临床结果之间的关系进行了纵向测试。结果我们发现色氨酸羟化酶 1 (TPH1) rs1800532 与 FND 症状严重程度（CGI1）之间存在名义上的关联，在共显性模型下（T/T：ßT/T = 2.31，seT/T = 0.57；G/T：ßG/T = -0.18，seG/T = 0.29，P = 0.035），小等位基因（T）携带者的症状更严重。研究发现，TPH1与临床结果之间存在关联，在显性模型下，大等位基因（G）携带者更有可能获得更好的结果（G/T：ORG/T = 0.18，CIG/T = [0.02-1.34]；T/T：ORT/T = 2.08，CIT/T = [0.30-14.53]，P = 0.041）。我们的分析表明，TPH2（rs4570625）和 OXTR（rs2254298）对症状严重程度有显著的基因-基因相互作用，TPH1、TPH2 和 BDNF（rs1491850）对临床结果有显著的基因-基因相互作用。

{"title":"The impact of genetic variations in the serotonergic system on symptom severity and clinical outcome in functional neurological disorders","authors":"","doi":"10.1016/j.jpsychores.2024.111909","DOIUrl":"10.1016/j.jpsychores.2024.111909","url":null,"abstract":"<div><h3>Objective</h3><p>We studied gene-environment, as well as gene-gene interaction to elucidate their effects on symptom severity and predict clinical outcomes in functional neurological disorders (FND).</p></div><div><h3>Methods</h3><p>Eighty-five patients with mixed FND were genotyped for ten single-nucleotide polymorphisms (SNP) from seven different stress-related genes. We tested cross-sectionally the association between genotype and the symptomatology of FND (symptom severity assessed with the examiner-based clinical global impression score [CGI] and age of onset). Clinical outcome was assessed in 52 patients who participated in a follow-up clinical visit after eight months (following their individual therapies as usual). We tested longitudinally the association between genotype and clinical outcome in FND. We examined the contribution of each SNP and their interaction between them to FND symptomatology and outcome.</p></div><div><h3>Results</h3><p>We identified a nominal association between tryptophan hydroxylase 1 (<em>TPH1</em>) rs1800532 and symptom severity (CGI<sub>1</sub>) in FND under a codominant model (T/T: ß<sub>T/T</sub> = 2.31, se<sub>T/T</sub> = 0.57; G/T: ß<sub>G/T</sub> = -0.18, se<sub>G/T</sub> = 0.29, <em>P</em> = 0.035), with minor allele (T) carriers presenting more severe symptoms. An association was identified between <em>TPH1</em> and clinical outcome, suggesting that major allele (G) carriers were more likely to have an improved outcome under a codominant model (G/T: OR<sub>G/T</sub> = 0.18, CI<sub>G/T</sub> = [0.02–1.34]; T/T: OR<sub>T/T</sub> = 2.08, CI<sub>T/T</sub> = [0.30–14.53], <em>P</em> = 0.041). Our analyses suggested a significant gene-gene interaction for <em>TPH2</em> (rs4570625) and <em>OXTR</em> (rs2254298) on symptom severity, and a significant gene-gene interaction for <em>TPH1</em>, <em>TPH2</em> and <em>BDNF</em> (rs1491850) on clinical outcome.</p></div><div><h3>Conclusion</h3><p>FND might arise from a complex interplay between individual predisposing risk genes involved in the serotonergic pathway and their gene-gene interactions.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924003210/pdfft?md5=528576b886c00297cd9eca63c63c7a61&pid=1-s2.0-S0022399924003210-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroticism and cognitive correlates of depression and anxiety in endometriosis: A meta-analytic review, evidence appraisal, and future recommendations 子宫内膜异位症患者抑郁和焦虑的神经质和认知相关性：荟萃分析回顾、证据评估和未来建议

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-08-30 DOI: 10.1016/j.jpsychores.2024.111906

Objective

This meta-analytic review aimed to synthesise evidence on personality and cognitive factors related to depression and anxiety in endometriosis and determine whether sociodemographic and clinical variables moderate factor-symptom relations. Additionally, this review aimed to evaluate the quality of research and formulate recommendations for future research.

Methods

A systematic search was conducted across databases (Medline, Embase, PsycInfo, Web of Science, ProQuest) through to February 2024. Search terms were used for endometriosis, depression, anxiety, cognitive factors and personality traits. Random-effects meta-analyses were conducted to produce pooled weighted effects (r) for factor-symptom relationships.

Results

Thirteen studies (11 samples; N = 3287; M_age 33.89 ± 2.48) were included in a narrative synthesis. One study provided evidence for a positive association between neuroticism and depression. Seven studies contributed to meta-analyses on three cognitive factors. Medium-to-large associations were identified between illness perceptions of low control/power (r = 0.35, 95 % CI: 0.01,0.62), rumination (r = 0.52, 95 % CI: 0.09, 0.78), pain-catastrophising (r = 0.37, 95 % CI: 0.28, 0.45) and higher levels of depression. The statistical power to detect significant effects was >80 %. Findings for anxiety were non-significant, although limited data were available. Quality appraisal revealed a high risk of within-study bias (4.69 ± 1.38, range: 3–7), with issues related to sample representativeness and measurement selection.

Conclusion

Rumination, pain-catastrophising, and illness perceptions of low control/power are important in understanding depression in endometriosis. There is a lack of research on personality traits, necessitating further study. Findings highlight the importance of prioritising modifiable cognitive factors in psychological research and clinical practice in endometriosis.

目的本荟萃分析综述旨在综合与子宫内膜异位症患者抑郁和焦虑相关的人格和认知因素的证据，并确定社会人口学和临床变量是否会调节因素与症状之间的关系。此外，本综述还旨在评估研究质量，并为未来研究提出建议。方法：对截至 2024 年 2 月的数据库（Medline、Embase、PsycInfo、Web of Science、ProQuest）进行了系统检索。检索词包括子宫内膜异位症、抑郁、焦虑、认知因素和人格特质。结果13项研究（11个样本；N = 3287；Mage 33.89 ± 2.48）被纳入叙述性综述。其中一项研究证明神经质与抑郁之间存在正相关。七项研究对三个认知因素进行了荟萃分析。研究发现，对疾病的低控制/低能力感知（r = 0.35，95 % CI：0.01,0.62）、反刍（r = 0.52，95 % CI：0.09,0.78）、疼痛-灾难化（r = 0.37，95 % CI：0.28,0.45）与抑郁程度较高之间存在中到大型的关联。检测重大影响的统计能力为 80%。尽管数据有限，但焦虑方面的研究结果并不显著。质量评估显示，研究内部偏倚的风险较高（4.69 ± 1.38，范围：3-7），存在与样本代表性和测量选择相关的问题。由于缺乏对人格特质的研究，因此有必要开展进一步研究。研究结果强调了在子宫内膜异位症的心理研究和临床实践中优先考虑可改变的认知因素的重要性。

{"title":"Neuroticism and cognitive correlates of depression and anxiety in endometriosis: A meta-analytic review, evidence appraisal, and future recommendations","authors":"","doi":"10.1016/j.jpsychores.2024.111906","DOIUrl":"10.1016/j.jpsychores.2024.111906","url":null,"abstract":"<div><h3>Objective</h3><p>This meta-analytic review aimed to synthesise evidence on personality and cognitive factors related to depression and anxiety in endometriosis and determine whether sociodemographic and clinical variables moderate factor-symptom relations. Additionally, this review aimed to evaluate the quality of research and formulate recommendations for future research.</p></div><div><h3>Methods</h3><p>A systematic search was conducted across databases (Medline, Embase, PsycInfo, Web of Science, ProQuest) through to February 2024. Search terms were used for endometriosis, depression, anxiety, cognitive factors and personality traits. Random-effects meta-analyses were conducted to produce pooled weighted effects (<em>r</em>) for factor-symptom relationships.</p></div><div><h3>Results</h3><p>Thirteen studies (11 samples; <em>N</em> = 3287; M<sub>age</sub> 33.89 ± 2.48) were included in a narrative synthesis. One study provided evidence for a positive association between neuroticism and depression. Seven studies contributed to meta-analyses on three cognitive factors. Medium-to-large associations were identified between illness perceptions of low control/power (<em>r</em> = 0.35, 95 % CI: 0.01,0.62), rumination (<em>r</em> = 0.52, 95 % CI: 0.09, 0.78), pain-catastrophising (<em>r</em> = 0.37, 95 % CI: 0.28, 0.45) and higher levels of depression. The statistical power to detect significant effects was >80 %. Findings for anxiety were non-significant, although limited data were available. Quality appraisal revealed a high risk of within-study bias (4.69 ± 1.38, range: 3–7), with issues related to sample representativeness and measurement selection.</p></div><div><h3>Conclusion</h3><p>Rumination, pain-catastrophising, and illness perceptions of low control/power are important in understanding depression in endometriosis. There is a lack of research on personality traits, necessitating further study. Findings highlight the importance of prioritising modifiable cognitive factors in psychological research and clinical practice in endometriosis.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924003180/pdfft?md5=529d62b42fc285a09c8de50fd79e9189&pid=1-s2.0-S0022399924003180-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving stroke rehabilitation: The role of physical activity and mental health support 改善中风康复：体育活动和心理健康支持的作用

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-08-30 DOI: 10.1016/j.jpsychores.2024.111907

引用次数: 0

Reducing suicidal ideation among chronic disease patients through integrated care 通过综合护理减少慢性病患者的自杀倾向

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-08-30 DOI: 10.1016/j.jpsychores.2024.111905

引用次数: 0

Letter to the editor: “Mental health and lower urinary tract symptoms: Results from the NHANES and Mendelian randomization study” 致编辑的信："心理健康与下尿路症状：NHANES 和孟德尔随机研究的结果"

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-08-28 DOI: 10.1016/j.jpsychores.2024.111908

引用次数: 0

Side-effect expectations are associated with disability, physical fitness, and somatic symptoms 3 months after post-COVID neurological inpatient rehabilitation 副作用预期与 COVID 后神经系统住院康复 3 个月后的残疾、体能和躯体症状有关

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-08-24 DOI: 10.1016/j.jpsychores.2024.111902

Introduction

The COVID-19 pandemic, caused by SARS-CoV-2, has led to long-term health issues known as post-COVID-19 condition, including fatigue and cognitive disruptions. Despite its recognition as a public health concern, the efficacy of therapeutic interventions, especially in neurological rehabilitation, remains unclear. This study examines how treatment expectations are associated with psychological and physical outcomes in post-COVID-19 condition neurological rehabilitation.

Methods

In an observational cohort study 61 patients with confirmed post-COVID-19 condition were included. Baseline (T0) data on treatment and side effect expectations were collected, before participants underwent a 4–6 week multidisciplinary rehabilitation program. Primary outcome was illness-related disability (Pain Disability Index). Secondary outcomes included depressive symptoms (PHQ-9), anxiety levels (GAD-7), functional status (PCFS), fatigue (CFS), and physical fitness (6MWT). Regression models analyzed the associations of baseline expectations with outcomes at the end of rehabilitation (T1) and three months post-rehabilitation (T2).

Results

After adjusting for multiple testing, higher baseline side-effect expectations were associated with greater illness-related disability (β = 0.42, p = 0.007), reduced physical fitness (β = − 0.24, p = 0.04), and more somatic symptoms (β = 0.33, p = 0.006) at follow-up (T2). Positive treatment expectations were associated with poorer functional status (β = 0.35, p = 0.011) at T2.

Conclusion

This study highlights the associations of side-effect expectations with post-COVID-19 condition rehabilitation outcomes. Higher side-effect expectations were associated to poorer outcomes, indicating a nocebo effect. Surprisingly, positive expectations were linked to worse outcomes, possibly due to unrealistic optimism. Managing patient expectations realistically and addressing side-effect concerns seems crucial for optimizing rehabilitation outcomes.

导言：由 SARS-CoV-2 引起的 COVID-19 大流行导致了被称为 COVID-19 后遗症的长期健康问题，包括疲劳和认知障碍。尽管人们已认识到这是一个公共卫生问题，但治疗干预措施的效果，尤其是在神经康复方面的效果仍不明确。本研究探讨了治疗期望与 COVID-19 后遗症神经康复中的心理和生理结果之间的关系。方法在一项观察性队列研究中，纳入了 61 名确诊为 COVID-19 后遗症的患者。在参与者接受为期 4-6 周的多学科康复计划之前，收集了有关治疗和副作用预期的基线（T0）数据。主要结果是与疾病相关的残疾（疼痛残疾指数）。次要结果包括抑郁症状（PHQ-9）、焦虑水平（GAD-7）、功能状态（PCFS）、疲劳（CFS）和体能（6MWT）。回归模型分析了基线期望与康复结束时（T1）和康复后三个月（T2）的结果之间的关系。结果经多重测试调整后，基线副作用期望越高，随访（T2）时与疾病相关的残疾程度越高（β = 0.42，p = 0.007），体能下降（β = - 0.24，p = 0.04），躯体症状越多（β = 0.33，p = 0.006）。积极的治疗期望与 T2 阶段较差的功能状态相关（β = 0.35，p = 0.011）。较高的副作用预期与较差的康复效果相关，这表明存在着一种 "安慰剂效应"。令人惊讶的是，积极的预期与较差的疗效相关，这可能是由于不切实际的乐观所致。实事求是地管理患者的期望值并解决副作用问题似乎对优化康复效果至关重要。

{"title":"Side-effect expectations are associated with disability, physical fitness, and somatic symptoms 3 months after post-COVID neurological inpatient rehabilitation","authors":"","doi":"10.1016/j.jpsychores.2024.111902","DOIUrl":"10.1016/j.jpsychores.2024.111902","url":null,"abstract":"<div><h3>Introduction</h3><p>The COVID-19 pandemic, caused by SARS-CoV-2, has led to long-term health issues known as post-COVID-19 condition, including fatigue and cognitive disruptions. Despite its recognition as a public health concern, the efficacy of therapeutic interventions, especially in neurological rehabilitation, remains unclear. This study examines how treatment expectations are associated with psychological and physical outcomes in post-COVID-19 condition neurological rehabilitation.</p></div><div><h3>Methods</h3><p>In an observational cohort study 61 patients with confirmed post-COVID-19 condition were included. Baseline (T0) data on treatment and side effect expectations were collected, before participants underwent a 4–6 week multidisciplinary rehabilitation program. Primary outcome was illness-related disability (Pain Disability Index). Secondary outcomes included depressive symptoms (PHQ-9), anxiety levels (GAD-7), functional status (PCFS), fatigue (CFS), and physical fitness (6MWT). Regression models analyzed the associations of baseline expectations with outcomes at the end of rehabilitation (T1) and three months post-rehabilitation (T2).</p></div><div><h3>Results</h3><p>After adjusting for multiple testing, higher baseline side-effect expectations were associated with greater illness-related disability (β = 0.42, <em>p</em> = 0.007), reduced physical fitness (β = − 0.24, <em>p</em> = 0.04), and more somatic symptoms (β = 0.33, <em>p</em> = 0.006) at follow-up (T2). Positive treatment expectations were associated with poorer functional status (β = 0.35, <em>p</em> = 0.011) at T2.</p></div><div><h3>Conclusion</h3><p>This study highlights the associations of side-effect expectations with post-COVID-19 condition rehabilitation outcomes. Higher side-effect expectations were associated to poorer outcomes, indicating a nocebo effect. Surprisingly, positive expectations were linked to worse outcomes, possibly due to unrealistic optimism. Managing patient expectations realistically and addressing side-effect concerns seems crucial for optimizing rehabilitation outcomes.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924003143/pdfft?md5=83501aa2369d753b012a83d20c9d61eb&pid=1-s2.0-S0022399924003143-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142083878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0