Journal of Psychosomatic Research最新文献_第3页

Bridging cultures: Expanding the MCARE intervention to diverse global Populations 架设文化桥梁：将 MCARE 干预措施扩展至全球不同人群

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-09 DOI: 10.1016/j.jpsychores.2024.111948

引用次数: 0

The association between anxiety and depression symptoms and pain and function in adolescents and young adults with chronic pain: A meta-analysis 患有慢性疼痛的青少年中焦虑和抑郁症状与疼痛和功能之间的关系：荟萃分析

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-01 DOI: 10.1016/j.jpsychores.2024.111945

Objective

Chronic pain in adolescents and young adults (AYAs) is associated with adverse functional and psychological outcomes; however, inconsistent findings across studies necessitate a comprehensive synthesis. This meta-analysis aimed to quantify associations between anxiety, depression, and pain/functional outcomes, and explore study and sample moderators, such as age, sex, pain duration, recruitment setting, and measurement tools.

Methods

We searched MEDLINE, PsycINFO, CENTRAL, and Embase through May 2024. included 57 studies (N = 12,603) of AYAs aged 12–25 years with chronic pain. Risk of bias and GRADE assessments were conducted. Pearson r correlations were meta-analyzed using a random-effects model.

Results

Small associations were found between anxiety, depression, and heightened pain intensity (r = 0.20, 0.24). Moderate-to-large associations were observed between anxiety, depression, and disability (r = 0.32, 0.34), pain interference (r = 0.47, 0.51), pain catastrophizing (both r = 0.50), and poorer quality of life (r = −0.56, −0.61). Anxiety had stronger correlations with pain intensity and catastrophizing in samples with more males. Anxiety measure moderated the anxiety-pain intensity relationship. Depression had stronger correlations with pain intensity for shorter pain duration, and catastrophizing and pain interference for longer pain durations. The depression-catastrophizing association was stronger in older samples.

Conclusion

Anxiety and depression significantly impact the chronic pain experience in AYAs, with stronger effects on functional outcomes and quality of life than pain intensity. Tailored interventions that consider age, sex, and pain duration may enhance treatment outcomes in this population.

目的：青少年和年轻成人（AYAs）的慢性疼痛与不良的功能和心理结果有关；然而，由于各项研究的结果不一致，因此有必要进行综合分析。本荟萃分析旨在量化焦虑、抑郁和疼痛/功能性结果之间的关联，并探讨研究和样本调节因素，如年龄、性别、疼痛持续时间、招募环境和测量工具等：我们检索了截至 2024 年 5 月的 MEDLINE、PsycINFO、CENTRAL 和 Embase，共纳入 57 项研究（N = 12603），研究对象为 12-25 岁患有慢性疼痛的青少年。进行了偏倚风险和 GRADE 评估。采用随机效应模型对 Pearson r 相关性进行了元分析：焦虑、抑郁和疼痛强度增加之间存在微小关联（r = 0.20、0.24）。焦虑、抑郁与残疾（r = 0.32，0.34）、疼痛干扰（r = 0.47，0.51）、疼痛灾难化（均为 r = 0.50）和较差的生活质量（r = -0.56，-0.61）之间存在中度至高度关联。在男性较多的样本中，焦虑与疼痛强度和灾难化的相关性更强。焦虑测量调节了焦虑与疼痛强度之间的关系。在疼痛持续时间较短的样本中，抑郁与疼痛强度的相关性更强；在疼痛持续时间较长的样本中，灾难化与疼痛干扰的相关性更强。在年龄较大的样本中，抑郁与灾难化的相关性更强：结论：焦虑和抑郁会严重影响亚健康人群的慢性疼痛体验，与疼痛强度相比，焦虑和抑郁对功能结果和生活质量的影响更大。考虑年龄、性别和疼痛持续时间的定制干预措施可提高该人群的治疗效果。

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引用次数: 0

A cross-sectional study of non-suicidal self-injury in adults with depressive disorder: Associations with inflammation and cardiac structure and function 抑郁症成人非自杀性自伤横断面研究：与炎症及心脏结构和功能的关系

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-28 DOI: 10.1016/j.jpsychores.2024.111944

Objective

Non-suicidal self-injury (NSSI) is associated with cardiovascular disease (CVD), whereas inflammation is associated with both CVD and NSSI. However, few studies have investigated the correlation among NSSI, inflammation, and cardiac structure and function in CVD-free adult patients with depressive disorders.

Methods

We recruited 88 CVD-free adult patients with depressive disorders and 37 healthy individuals. Patients were divided into NSSI (n = 21) and non-NSSI (n = 67) groups based on the presence or absence of NSSI. Healthy individuals comprised the controls (n = 37). Echocardiography was applied to assess cardiac structure and function, and C-reactive protein (CRP) levels were measured to indicate inflammation.

Results

Compared with controls, the NSSI group exhibited a larger left ventricular end-systolic diameter (LVESD) and smaller left ventricular ejection fraction (LVEF). Left ventricular end-systolic volume (LVESV) was larger in the NSSI group than in the non-NSSI group. The CRP levels were higher in the NSSI group than in the non-NSSI group; however, this difference was not statistically significant. NSSI was positively associated with LVESD (β = 1.928, p = 0.006) and LVESV (β = 5.368, p = 0.003), negatively correlated with LVEF (β = −2.600, p = 0.029), and positively correlated with CRP levels (β = 0.116, p = 0.004). CRP levels did not mediate the association between NSSI and cardiac structure and function.

Conclusions

This study indicated that NSSI was associated with left ventricular structure, systolic function, and inflammation, but CRP did not mediate the relationship between NSSI and echocardiogram parameters.

目的：非自杀性自伤（NSSI）与心血管疾病（CVD）有关，而炎症与心血管疾病和非自杀性自伤都有关。然而，很少有研究调查无心血管疾病的成年抑郁症患者的 NSSI、炎症、心脏结构和功能之间的相关性：我们招募了 88 名无心血管疾病的成年抑郁症患者和 37 名健康人。根据有无NSSI将患者分为NSSI组（21人）和非NSSI组（67人）。健康人为对照组（37 人）。超声心动图用于评估心脏结构和功能，C反应蛋白（CRP）水平的测量用于显示炎症情况：结果：与对照组相比，NSSI 组的左心室收缩末期直径（LVESD）较大，左心室射血分数（LVEF）较小。NSSI组的左心室收缩末期容积（LVESV）大于非NSSI组。NSSI 组的 CRP 水平高于非 NSSI 组，但差异无统计学意义。NSSI 与 LVESD（β = 1.928，p = 0.006）和 LVESV（β = 5.368，p = 0.003）呈正相关，与 LVEF 呈负相关（β = -2.600，p = 0.029），与 CRP 水平呈正相关（β = 0.116，p = 0.004）。CRP水平并不介导NSSI与心脏结构和功能之间的关联：本研究表明，NSSI 与左心室结构、收缩功能和炎症有关，但 CRP 并不介导 NSSI 与超声心动图参数之间的关系。

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引用次数: 0

Associations of preterm birth and neonatal stress exposure with chronic pain in adulthood – Results from the Gutenberg prematurity study 早产和新生儿压力暴露与成年后慢性疼痛的关系--古腾堡早产儿研究的结果

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-24 DOI: 10.1016/j.jpsychores.2024.111943

Although the effect of early childhood stress on central nervous pain processing is well known, studies on the association of prematurity and chronic pain are scarce. This study used data from a single-centre retrospective cohort study followed by a prospective clinical examination and pain assessment. The study was based on data from the local birth registry. Newborns born between 1969 and 2002 who had reached adulthood were eligible .. Using a selection algorithm, a study cohort stratified by gestational age (GA) was recruited. Chronic pain conditions were assessed using questionnaire and standardized pain drawings. Data on the pre-, peri- and postnatal clinical course was assessed from medical records. Multivariable logistic regression analyses were conducted to investigate associations between prematurity and chronic pain with adjustment for age, gender, socioeconomic status, and perinatal stress factors. 427 participants born preterm and full-term were included (age 28.5 ± 8.7 years). Chronic pain conditions were similarly common between groups with different levels of prematurity (GA ≥ 37 weeks: 34.5 %, GA33-36 weeks: 37.6 %, GA32-29 weeks: 25.2 %, GA < 29 weeks: 30.4 %, p = 0.20). In multivariable analyses, no association between low GA and the presence of chronic pain was found (OR = 0.99 (CI95 %: 0.94–1.04, p = 0.63); this was also true for a subanalysis of widespread pain. While neither fetal nutritional status nor perinatal stressors were associated with pain, exposure to maternal but not paternal smoking during pregnancy was associated with increased risk to develop pain (OR = 2.77 (CI95 %: 1.31–5.88, p = 0.008) in adults born preterm and full-term. This study suggests that prematurity by itself does not increase the risk of chronic pain later in life, but provides preliminary evidence for maternal smoking during pregnancy as risk factor.

早产儿的压力对中枢神经疼痛处理的影响已众所周知，但有关早产儿与慢性疼痛关系的研究却很少。本研究使用了一项单中心回顾性队列研究的数据，随后进行了前瞻性临床检查和疼痛评估。该研究基于当地出生登记处的数据。通过选择算法，按孕龄（GA）分层招募了研究队列。研究人员使用调查问卷和标准化疼痛图纸对慢性疼痛状况进行了评估。产前、围产期和产后的临床过程数据来自医疗记录。在对年龄、性别、社会经济地位和围产期压力因素进行调整后，进行了多变量逻辑回归分析，以研究早产与慢性疼痛之间的关联。研究共纳入 427 名早产儿和足月儿（年龄为 28.5 ± 8.7 岁）。在早产程度不同的组别中，慢性疼痛的发生率相似（GA ≥ 37 周：34.5%；GA33-33 周：34.5%；GA ≥ 37 周：34.5%）：34.5%，GA33-36周：37.6%，GA32-29周：34.5%，GA33-36周：37.6%，GA32-29周：34.5%：37.6%，GA32-29 周：25.2%，GA &l：25.2 %, GA < 29 weeks：30.4 %, p = 0.20).在多变量分析中，未发现低GA与慢性疼痛之间存在关联（OR = 0.99 (CI95 %: 0.94-1.04, p = 0.63)；在广泛性疼痛的子分析中也是如此。虽然胎儿营养状况和围产期压力因素都与疼痛无关，但在早产和足月出生的成人中，孕期母体（而非父体）吸烟与罹患疼痛的风险增加有关（OR = 2.77（CI95 %：1.31-5.88，p = 0.008）。这项研究表明，早产本身并不会增加日后罹患慢性疼痛的风险，但提供了母体在孕期吸烟是风险因素的初步证据。

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引用次数: 0

Exploring the relationship between depression, anxiety, and obesity in adolescent development 探索青少年成长过程中抑郁、焦虑和肥胖之间的关系

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-24 DOI: 10.1016/j.jpsychores.2024.111939

引用次数: 0

Development of predictive model for post-stroke depression at discharge based on decision tree algorithm: A multi-center hospital-based cohort study 基于决策树算法的卒中后出院抑郁预测模型的开发：基于医院的多中心队列研究

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-24 DOI: 10.1016/j.jpsychores.2024.111942

Objective

Post-stroke depression (PSD) is one of the most common and severe neuropsychological sequelae after stroke. Using a prediction model composed of multiple predictors may be more beneficial than verifying the predictive performance of any single predictor. The primary objective of this study was to construct practical prediction tools for PSD at discharge utilizing a decision tree (DT) algorithm.

Methods

A multi-center prospective cohort study was conducted from May 2018 to October 2019 and stroke patients within seven days of onset were consecutively recruited. The independent predictors of PSD at discharge were identified through multivariate logistic regression with backward elimination. Classification and regression tree (CART) algorithm was employed as the DT model's splitting method.

Results

A total of 876 stroke patients who were discharged from the neurology departments of three large general Class A tertiary hospitals in Wuhan were eligible for analysis. Firstly, we divided these 876 patients into PSD and non-PSD groups, history of coronary heart disease (OR = 1.835; 95 % CI, 1.106–3.046; P = 0.019), length of hospital stay (OR = 1.040; 95 % CI, 1.013–1.069; P = 0.001), NIHSS score (OR = 1.124; 95 % CI, 1.052–1.201; P = 0.001), and Mini mental state examination (MMSE) score (OR = 0.935; 95 % CI, 0.893–0.978; P = 0.004) were significant predictors. The subgroup analysis results have shown that hemorrhagic stroke, history of hypertension and higher modified Rankin Scale score (mRS) score were associated with PSD at discharge in the young adult stroke patients.

Conclusions

Several predictors of PSD at discharge were identified and convenient DT models were constructed to facilitate clinical decision-making.

目的中风后抑郁（PSD）是中风后最常见、最严重的神经心理后遗症之一。使用由多个预测因子组成的预测模型可能比验证任何单一预测因子的预测性能更有益处。本研究的主要目的是利用决策树（DT）算法构建出院时 PSD 的实用预测工具。方法于 2018 年 5 月至 2019 年 10 月开展了一项多中心前瞻性队列研究，连续招募了发病七天内的卒中患者。通过多变量逻辑回归和反向排除法确定了出院时 PSD 的独立预测因素。结果武汉市三家大型甲级综合三甲医院神经内科出院的 876 例脑卒中患者符合分析条件。首先，我们将这 876 例患者分为 PSD 组和非 PSD 组，冠心病史（OR = 1.835; 95 % CI, 1.106-3.046; P = 0.019）、住院时间（OR = 1.040; 95 % CI, 1.013-1.069；P = 0.001）、NIHSS 评分（OR = 1.124；95 % CI，1.052-1.201；P = 0.001）和迷你精神状态检查（MMSE）评分（OR = 0.935；95 % CI，0.893-0.978；P = 0.004）是重要的预测因素。亚组分析结果显示，出血性卒中、高血压病史和较高的改良 Rankin 量表评分（mRS）与青壮年卒中患者出院时的 PSD 相关。

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引用次数: 0

Comments on ‘Mechanisms of psycho-behavioural mindfulness intervention (MCARE) on depressive and anxiety symptoms in patients with acute coronary syndrome: A longitudinal mediation analysis’ 关于 "心理行为正念干预（MCARE）对急性冠状动脉综合征患者抑郁和焦虑症状的影响机制：纵向中介分析

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-21 DOI: 10.1016/j.jpsychores.2024.111941

引用次数: 0

The association between overweight and varying degrees of obesity with subjective well-being and depressive symptoms: A two sample Mendelian randomization study 超重和不同程度的肥胖与主观幸福感和抑郁症状之间的关系：两项孟德尔随机抽样研究

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-19 DOI: 10.1016/j.jpsychores.2024.111940

Objective

This study utilized the Mendelian randomization (MR) method to elucidate the causal relationship between genetically predicted overweight and various degrees of obesity with depressive symptoms and subjective well-being (SWB).

Methods

Pooled genome-wide association studies (GWAS) data for overweight (BMI ≥ 25 kg/m²), class 1 obesity (BMI ≥ 30 kg/m²), and class 2 obesity (BMI ≥ 35 kg/m²) were used as exposures. Summary GWAS data for depressive symptoms and SWB were used as outcomes. Multiple MR methods, primarily inverse-variance weighted (IVW), were applied, and sensitivity analyses were conducted to assess heterogeneity and pleiotropy.

Results

The MR analysis provided evidence that genetically predicted overweight(IVW β = 0.033; 95 %CI 0.008–0.057; P = 0.010) and class 1 obesity(IVW β = −0.033; 95 %CI -0.047 – -0.020; P < 0.001) were causally associated with increased depressive symptoms. Genetically predicted class 2 obesity(IVW β = 1.428; 95 %CI 1.193–1.710; P < 0.001) were associated with reduced SWB. There was no strong evidence of a causal association between genetically predicted overweight and class 1 obesity with SWB. Similarly, genetically predicted class 2 and class 3 obesity did not show strong evidence of a causal association with depressive symptoms. Sensitivity analysis revealed relationships of a similar magnitude.

Conclusion

This genetically informed MR study suggests that Overweight and class 1 obesity may causally increased depressive symptoms but not decrease SWB. In contrast, class 2 obesity may causally decrease SWB but not increase depressive symptoms.

方法将超重（体重指数≥ 25 kg/m2）、1 级肥胖（体重指数≥ 30 kg/m2）和 2 级肥胖（体重指数≥ 35 kg/m2）的全基因组关联研究（GWAS）数据作为暴露因子。抑郁症状和腰围的 GWAS 数据摘要被用作结果。结果MR分析表明，遗传预测的超重（IVW β = 0.033; 95 %CI 0.008-0.057; P = 0.010）和1级肥胖（IVW β = -0.033; 95 %CI -0.047-0.020; P < 0.001）与抑郁症状的增加有因果关系。遗传预测的 2 级肥胖（IVW β = 1.428; 95 %CI 1.193-1.710; P <0.001）与腰围减少有关。没有强有力的证据表明遗传预测的超重和一级肥胖与腰围之间存在因果关系。同样，遗传预测的 2 级和 3 级肥胖也没有显示出与抑郁症状有因果关系的有力证据。敏感性分析表明，两者之间存在类似程度的关系。结论这项基于基因的 MR 研究表明，超重和 1 级肥胖可能会增加抑郁症状，但不会降低腰围。与此相反，2 级肥胖可能会降低 SWB，但不会增加抑郁症状。

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引用次数: 0

Effects of psychological interventions on clinical outcomes in patients with cardiovascular diseases: A systematic review and meta-analysis 心理干预对心血管疾病患者临床疗效的影响：系统回顾与荟萃分析

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-19 DOI: 10.1016/j.jpsychores.2024.111938

Objective

To perform a systematic review and meta-analysis to evaluate the effects of psychological interventions on the clinical outcomes of patients with cardiovascular diseases (CVDs).

Methods

We searched PubMed, Web of Science, Embase, the Cochrane Library, and CINAHL from the establishment of each database to August 1, 2023. Randomized controlled trials (RCTs) on psychological interventions in patients with CVDs were included. Statistical analyses were performed using Review Manager 5.3 and Stata 17.0, and pooled measures were presented as the relative risk (RR) and 95 % confidence interval (CI).

Results

A total of 32 studies were included, involving 15,814 patients. Our results showed that psychological interventions could reduce cardiac mortality (RR = 0.81, 95 % CI = 0.68 to 0.96) and the occurrence of myocardial infarction (MI) (RR = 0.79, 95 % CI = 0.69 to 0.89), arrhythmia (RR = 0.61, 95 % CI = 0.42 to 0.89) and angina (RR = 0.92, 95 % CI = 0.87 to 0.97). However, no statistically significant differences were detected in the risk of all-cause mortality, all-cause rehospitalization rates, cardiac rehospitalization rates, revascularization, heart failure (HF), or stroke between the psychological intervention and control groups.

Conclusions

Psychological interventions can reduce cardiac mortality and the occurrence of MI, arrhythmia, and angina in patients with CVDs. It is crucial to incorporate psychological interventions into the existing treatment and management of patients with CVDs. High-quality RCTs should be conducted to explore the optimal psychological intervention methods and the maximum beneficiaries.

方法我们检索了 PubMed、Web of Science、Embase、Cochrane Library 和 CINAHL 等数据库从建立到 2023 年 8 月 1 日的内容。纳入了对心血管疾病患者进行心理干预的随机对照试验（RCT）。使用Review Manager 5.3和Stata 17.0进行统计分析，并以相对风险（RR）和95%置信区间（CI）的形式显示汇总结果。结果显示，心理干预可降低心脏病死亡率（RR = 0.81，95 % CI = 0.68 至 0.96）、心肌梗死（RR = 0.79，95 % CI = 0.69 至 0.89）、心律失常（RR = 0.61，95 % CI = 0.42 至 0.89）和心绞痛（RR = 0.92，95 % CI = 0.87 至 0.97）的发生率。结论心理干预可以降低心血管疾病患者的心脏死亡率以及心肌梗死、心律失常和心绞痛的发生率。将心理干预纳入心血管疾病患者的现有治疗和管理至关重要。应进行高质量的 RCT 研究，探索最佳的心理干预方法和最大的受益者。

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引用次数: 0

Climate change anxiety and its association with somatic symptom distress and idiopathic environmental intolerances: A cross-sectional study 气候变化焦虑及其与躯体症状困扰和特发性环境不耐受的关联：横断面研究

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-09-18 DOI: 10.1016/j.jpsychores.2024.111937

Context

Individuals need greater climate change awareness in order to mitigate and adapt to climate changes but this awareness can lead to negative health outcomes including climate change anxiety.

Objective

To explore the associations between climate change anxiety, idiopathic environmental intolerances and somatic symptom distress, after accounting for modern health worries, anxiety and depression.

Methods

A non-representative sample of healthy volunteers completed a cross-sectional online survey that included the Climate Change Anxiety scale (CCA-13), single questions about idiopathic intolerance to five environmental agents, the Somatic Symptoms scale (SSS-8), the Modern Health Worries scale (MHW-12), and the Patient Health Questionnaire for symptoms of anxiety and depression (PHQ-4). Participants also reported their sex, age and subjective socioeconomic status. Bivariate analyses investigated associations between variables and path analyses explored potential mediating factors.

Results

432 participants completed the questionnaire, 421 of whom were included in analyses (67 % women, mean age: 32.7 standard deviation: 12.4). Climate change anxiety, idiopathic environmental intolerances, somatic symptom distress, modern health worries, and symptoms of anxiety and depression were positively correlated in bivariate analyses (Pearson's ranging from 0.22 to 0.57, all p < 0.001). In path analyses, modern health worries (R² = 9.9 %) partially mediated the relation between climate change anxiety (R² = 20.3 %) and two correlated outcome variables, idiopathic environmental intolerances (R² = 36.8 %) and somatic symptom distress (R² = 32.4 %).

Conclusions

Climate change anxiety may negatively affect perceived physical health. Stakeholders should aim at promoting climate change awareness while addressing modern health worries to avoid negative health outcomes.

目的探讨在考虑了现代健康问题、焦虑和抑郁之后，气候变化焦虑、特发性环境不耐受与躯体症状困扰之间的关联。方法非代表性健康志愿者样本完成了一项横断面在线调查，其中包括气候变化焦虑量表（CCA-13）、关于对五种环境因素的特发性不耐受的单个问题、躯体症状量表（SSS-8）、现代健康担忧量表（MHW-12）以及针对焦虑和抑郁症状的患者健康问卷（PHQ-4）。参与者还报告了自己的性别、年龄和主观社会经济地位。双变量分析调查了变量之间的关联，路径分析探讨了潜在的中介因素。结果 432 名参与者填写了问卷，其中 421 人被纳入分析（67 % 为女性，平均年龄：32.7 岁，标准差：12.4）。在双变量分析中，气候变化焦虑、特发性环境不耐受、躯体症状困扰、现代健康担忧以及焦虑和抑郁症状呈正相关（Pearson's 从 0.22 到 0.57 不等，所有 P < 0.001）。在路径分析中，现代健康担忧（R2 = 9.9 %）在气候变化焦虑（R2 = 20.3 %）和两个相关结果变量（特发性环境不耐受（R2 = 36.8 %）和躯体症状困扰（R2 = 32.4 %）之间起到了部分中介作用。利益相关者在解决现代健康问题的同时，应致力于提高对气候变化的认识，以避免对健康造成负面影响。

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引用次数: 0