Journal of Psychosomatic Research最新文献_第4页

The impact of depression on risk of malignant glioma: A nationwide cohort study 抑郁症对恶性神经胶质瘤风险的影响：一项全国性队列研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychores.2024.111982

Jin Eun , Yoo Hyun Um , Kyungdo Han , Won-Il Joo , Seung Ho Yang

Background

Malignant glioma (MG) is a malignant brain tumor with a fatal prognosis. Depression is on the rise in society, and its negative association on prognosis of glioma patients is known. This study aimed to investigate the correlation between depression and MG risk by analyzing data from the Korean National Health Insurance System (NHIS).

Methods

A retrospective cohort study utilized NHIS data starting with 4,234,415 individuals aged 20 and above who had undergone health check-ups in 2009. Excluding 65,146 for cancer diagnosis, missing data, or a one-year lag period, 3,856,362 individuals were analyzed. Those diagnosed with depression per ICD-10 codes F32 or F33 before the check-ups formed the depression group, while the MG group was identified by ICD-10 code C71.

Results

Depression was found to have a significant association with glioma risk (hazard ratio 1.127, 95 % confidence interval 1.101–1.347), even with adjustment for age, sex, income, body-mass index (BMI), smoking, drinking, regular exercise, diabetes mellitus, hypertension and dyslipidemia. Furthermore, the severity of depression had a greater influence on MG incidence. Finally, subgroup analysis according to MG status revealed factors such as income, regular exercise, chronic kidney disease, and BMI to exhibit significant differences related to depression in the no-glioma group, but not in the glioma group.

Conclusions

These results suggest that depression may be associated with development of MG.

背景：恶性胶质瘤是一种预后致命的恶性脑肿瘤。抑郁症在社会上呈上升趋势，其与胶质瘤患者预后的负相关是已知的。本研究旨在通过分析韩国国民健康保险系统（NHIS）的数据，探讨抑郁症与MG风险之间的相关性。方法：一项回顾性队列研究利用NHIS数据，从2009年接受健康检查的年龄在20岁及以上的4,234,415人开始。排除65,146例癌症诊断、缺失数据或一年滞后期，共分析了3,856,362人。检查前根据ICD-10代码F32或F33诊断为抑郁症的人称为抑郁症组，而根据ICD-10代码C71诊断为MG组。结果：即使调整了年龄、性别、收入、身体质量指数（BMI）、吸烟、饮酒、定期运动、糖尿病、高血压和血脂异常等因素，抑郁症与胶质瘤发生风险仍存在显著相关性（危险比1.127,95%可信区间1.101 ~ 1.347）。此外，抑郁症的严重程度对MG发病率的影响更大。最后，根据MG状态进行亚组分析，发现收入、定期运动、慢性肾脏疾病和BMI等因素在非胶质瘤组中与抑郁相关的差异显著，而胶质瘤组中没有。结论：这些结果提示抑郁症可能与MG的发生有关。

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引用次数: 0

First results from a multimodal psychosomatic post-COVID treatment approach - a prospective longitudinal study 第一个结果来自多模式心身治疗方法-一项前瞻性纵向研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychores.2024.112021

Hanna Hofmann , Angela Fricke , Benjamin Krüger , Paul Köbler , Claudia Lanza , Stephan Zeiß , Jan Cernohorsky , Christine Hertle , Eva Krauss-Köstler , Peter Radermacher , Barbara Stein , Markus Müller , Christiane Waller

Background

Clinical experiences using a psychosomatic-oriented multimodal treatment approach in patients with post-COVID are promising. We established a half-day multimodal treatment program for post-COVID patients at the Department of Psychosomatic Medicine at General Hospital Nuremberg, Paracelsus Medical University, Germany.

Methods

This observational study between January 2022 and March 2023 comprised baseline documentation of Patient Health Questionnaire (PHQD), ICD-10 Symptom Rating (ISR), Fatigue Scale (FS) and Health Status Questionnaire (SF-12) at admission and discharge of 65 patients suffering from post-COVID. Multimodal psychosomatic treatment was scheduled for 3–4 weeks.

Results

At admission, PHQ and FS showed a high level of somatic symptom burden (PHQ-15: M = 16.0, SD = 5.6) and fatigue symptoms (FS: M = 27.1, SD = 4.4). Depressive (PHQ-9: M = 14.0, SD = 5.3) and anxiety symptoms (GAD-7: M = 9.6, SD = 5.6) were moderately and mildly pronounced, respectively. Compared to patients from our standard clinical settings post-COVID patients had a comparably high or even higher mental symptom burden (e.g. PHQ-15: p < .001, d = 0.79; PHQ-9: p = .009, d = 0.39). Compared to admission, symptomatology of post-COVID patients at discharge was improved (e.g. PHQ-15: p = .004, d = 0.26; FS: p = .009, d = 0.32).

Conclusions

Despite the short duration of treatment, the patients showed a significant reduction in symptoms between admission and discharge. Further data including a control group and extending the duration of treatment will show whether the changes in symptoms are of the multimodal psychosomatic treatment.

背景：以心身为导向的多模式治疗新冠肺炎后患者的临床经验是有希望的。我们在德国巴拉塞尔苏斯医科大学纽伦堡总医院心身医学部为新冠肺炎后患者建立了为期半天的多模式治疗方案。方法：本观察性研究于2022年1月至2023年3月期间对65例新冠肺炎患者入院和出院时的患者健康问卷（PHQD）、ICD-10症状评分（ISR）、疲劳量表（FS）和健康状况问卷（SF-12）进行基线记录。多模式心身治疗计划3-4周。结果：入院时，PHQ和FS表现出高水平的躯体症状负担（PHQ-15: M = 16.0, SD = 5.6）和疲劳症状（FS: M = 27.1, SD = 4.4）。抑郁症状（PHQ-9: M = 14.0, SD = 5.3）和焦虑症状（GAD-7: M = 9.6, SD = 5.6）分别为中度和轻度。与我们标准临床环境的患者相比，新冠肺炎后患者的精神症状负担相对较高，甚至更高（例如PHQ-15: p）。结论：尽管治疗时间较短，但患者入院和出院期间症状明显减轻。包括对照组和延长治疗时间在内的进一步数据将显示症状的变化是否属于多模式心身治疗。

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引用次数: 0

Risk of somatic symptom disorder in people with major medical disorders: Cross-sectional results from the population-based Hamburg City Health Study 主要医学疾病患者躯体症状障碍的风险：基于人群的汉堡市健康研究的横断面结果

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychores.2024.111997

Laura Buck , Luisa Peters , Kerstin Maehder , Friederike Hartel , Hanno Hoven , Volker Harth , Martin Härter , Bernd Löwe , Anne Toussaint

Background

Somatic Symptom Disorder (SSD) is characterized by excessive thoughts, emotions, and behaviors related to physical symptoms irrespective of their etiology. Estimates of SSD frequency assessed via self-report questionnaires range between 6.7% (general population) and 53% (specialized setting). This study aims to examine the frequency of risk of SSD and associated factors in people with Major Medical Disorders (MMD) using cross-sectional data from the population-based Hamburg City Health Study.

Methods

Risk of SSD was operationalized using the Somatic Symptom Scale-8, the Somatic Symptom Disorder-B Criteria Scale-12, and one item on symptom persistence. People at risk of SSD and not at risk were compared regarding biopsychosocial factors. Factors associated with risk of SSD were identified by hierarchical multiple logistic regression analysis.

Results

N = 1944 people (mean age 64.8 ± 8 years, 43.8% female) reported at least one MMD. Of those, 6.8% [95%, CI 5.6–7.9%] were at risk of SSD and reported greater healthcare utilization and lower health-related quality of life. Logistic regression identified higher age (p=.032), lower education (p=.002), number of somatic comorbidities (p<.001), and elevated neuroticism (p<.001) and depression (p<.001) scores as factors associated with risk of SSD, with an explained variance of Nagelkerke R²=0.45.

Conclusion

The observed frequency of risk of SSD in people with MMD does not point towards an excessive symptom burden in this sample. However, those at risk experience significant psychosocial burdens and increased healthcare utilization, highlighting a vulnerable subgroup prone to SSD.

背景：躯体症状障碍（SSD）的特征是与躯体症状相关的过多的思想、情绪和行为，而不考虑其病因。通过自我报告问卷评估的SSD频率估计范围在6.7%（一般人群）和53%（特殊环境）之间。本研究旨在利用基于人群的汉堡市健康研究的横断面数据，研究重度医学疾病（MMD）患者发生SSD风险的频率及其相关因素。方法：采用躯体症状量表-8、躯体症状障碍- b标准量表-12和症状持续性一项对SSD风险进行评估。在生物、心理、社会因素方面对有SSD风险和无SSD风险的人进行比较。通过分层多元logistic回归分析确定与SSD风险相关的因素。结果：N = 1944人（平均年龄64.8±8岁，女性43.8%）报告至少一次烟雾病。其中，6.8% [95%,CI 5.6-7.9%]存在SSD风险，并报告较高的医疗保健利用率和较低的健康相关生活质量。Logistic回归发现年龄较大（p= 0.032），受教育程度较低（p= 0.002），躯体合并症数量较多（p= 0.45）。结论：在烟雾病患者中观察到的SSD风险频率并不表明该样本中存在过度的症状负担。然而，那些有风险的人经历了严重的心理社会负担和增加的医疗保健利用，突出了一个易患SSD的弱势亚群体。

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引用次数: 0

Personality matters: Exploring the associations of personality traits with mood and somatic symptoms in multiple sclerosis 人格问题：探讨多发性硬化症患者人格特质与情绪和躯体症状的关系。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychores.2024.112022

Duygu Kuzu, Anna L. Kratz

Background

Research suggest that personality traits influence the mood and somatic symptoms in various different clinical populations. Neuroticism, extraversion, conscientiousness, openness to experience, and agreeableness have been identified as potential predictors of mood and somatic symptoms. However, the literature on personality traits and symptom outcomes in multiple sclerosis (MS) is limited, highlighting the necessity for more in-depth research.

Objective

This Cross-sectional study aimed to investigate the association between personality traits and symptomatology in individuals with MS using two separate studies and different personality assessment tools– the NEO Five-Factor Inventory (NEO-FFI) and the Ten Item Personality Inventory (TIPI).

Methods

Participants completed surveys assessing mood and somatic symptoms. Linear regression analyses were performed to examine the associations between personality traits and MS symptoms controlling for demographic variables.

Results

.The analyses were performed on data from 63 individuals with MS for Study 1 (assessing the NEO-FFI) and 1183 individuals with MS for Study 2 (assessing the TIPI), respectively. Neuroticism was consistently associated with more somatic and mood symptoms in both sample (medium to large effect sizes; β = −0.05 to β = 0.60) Extraversion and conscientiousness were associated with fewer symptoms in Study 2.

Conclusions

This study highlights the importance of considering personality factors in understanding and managing symptoms in MS. However, further research is needed to understand the causal relationships between personality and symptom outcomes in MS.

背景：研究表明，人格特质会影响不同临床人群的情绪和躯体症状。神经质、外向性、尽责性、经验开放性和亲和性已被确定为情绪和躯体症状的潜在预测因子。然而，关于多发性硬化症（MS）的人格特征和症状结局的文献有限，强调了更深入研究的必要性。目的：本横断面研究旨在通过两项独立研究和不同的人格评估工具- NEO五因素量表（NEO- ffi）和十项人格量表（TIPI）来探讨MS患者人格特征与症状之间的关系。方法：参与者完成评估情绪和躯体症状的调查。采用线性回归分析来检验人格特质与多发性硬化症症状之间的关系，控制人口统计学变量。结果：分别对研究1中63名MS患者（评估NEO-FFI）和研究2中1183名MS患者（评估TIPI）的数据进行了分析。在两个样本中，神经质始终与更多的躯体和情绪症状相关(中到大效应量；β = -0.05 ~ β = 0.60)研究2中，外向性和尽责性与症状减少相关。结论：本研究强调了人格因素在理解和治疗多发性硬化症症状中的重要性。然而，需要进一步研究人格与多发性硬化症症状结局之间的因果关系。

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引用次数: 0

Enhancing immunotherapy outcomes in advanced NSCLC: The role of sleep hygiene education and physical exercise as non-pharmacological interventions 提高晚期非小细胞肺癌的免疫治疗效果：睡眠卫生教育和体育锻炼作为非药物干预的作用

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-11-22 DOI: 10.1016/j.jpsychores.2024.111993

Sesilianus Fau , Erasma Fitilai Zalogo

引用次数: 0

Resilience, psychosomatic health, and support needs of Ukrainian healthcare professionals in wartime: A cross-sectional study 战时乌克兰医护人员的复原力、心身健康和支持需求：横断面研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-11-20 DOI: 10.1016/j.jpsychores.2024.111995

Anastasiia Yuriivna Sydorenko , Lennart Kiel , Helle Spindler

Background

As Ukraine enters its third year of war, healthcare professionals (HPs) continue to face ongoing challenges to their adaptability and resilience. This study aimed to assess the emotional and physical well-being of HPs, evaluate their resilience levels, and identify the most anticipated types of psychological support that would benefit them.

Methods

Emotional and somatic states were assessed using the Hospital Anxiety and Depression Scale (HADS) and the Patient Health Questionnaire (PHQ-15). Resilience was measured by the Connor-Davidson Resilience Scale (CD-RISC-10). Open-ended questions were used to identify anticipated measures of psychological support.

Results

A total of 1442 HPs participated in the study. The majority exhibited high levels of anxiety and depression. Resilience scores showed negative correlations with anxiety (r = −0.34), depression (r = −0.53), and somatic symptom severity (r = −0.36). The most desired types of psychological support included psychological counselling, spiritual support, and opportunities for rest.

Conclusion

It is essential to address the primary needs of HPs in Ukraine to support their professional and personal resilience during wartime. Psychological support should not only focus on treating symptoms and distress but also respond to deeper needs that foster hope and faith in a better future.

背景：随着乌克兰战争进入第三个年头，医疗保健专业人员（HPs）的适应能力和复原力继续面临持续挑战。本研究旨在评估医护人员的情绪和身体健康状况，评估他们的复原力水平，并确定最有望使他们受益的心理支持类型：方法：使用医院焦虑抑郁量表（HADS）和患者健康问卷（PHQ-15）评估情绪和躯体状态。复原力通过康纳-戴维森复原力量表（CD-RISC-10）进行测量。开放式问题用于确定预期的心理支持措施：共有 1442 名 HP 参与了研究。大多数人表现出高度焦虑和抑郁。复原力得分与焦虑（r = -0.34）、抑郁（r = -0.53）和躯体症状严重程度（r = -0.36）呈负相关。最需要的心理支持类型包括心理咨询、精神支持和休息机会：结论：必须满足乌克兰医护人员的主要需求，以支持他们在战时的职业和个人恢复能力。心理支持不仅应侧重于治疗症状和痛苦，还应满足更深层次的需求，以促进对更美好未来的希望和信念。

{"title":"Resilience, psychosomatic health, and support needs of Ukrainian healthcare professionals in wartime: A cross-sectional study","authors":"Anastasiia Yuriivna Sydorenko , Lennart Kiel , Helle Spindler","doi":"10.1016/j.jpsychores.2024.111995","DOIUrl":"10.1016/j.jpsychores.2024.111995","url":null,"abstract":"<div><h3>Background</h3><div>As Ukraine enters its third year of war, healthcare professionals (HPs) continue to face ongoing challenges to their adaptability and resilience. This study aimed to assess the emotional and physical well-being of HPs, evaluate their resilience levels, and identify the most anticipated types of psychological support that would benefit them.</div></div><div><h3>Methods</h3><div>Emotional and somatic states were assessed using the Hospital Anxiety and Depression Scale (HADS) and the Patient Health Questionnaire (PHQ-15). Resilience was measured by the Connor-Davidson Resilience Scale (CD-RISC-10). Open-ended questions were used to identify anticipated measures of psychological support.</div></div><div><h3>Results</h3><div>A total of 1442 HPs participated in the study. The majority exhibited high levels of anxiety and depression. Resilience scores showed negative correlations with anxiety (<em>r</em> = −0.34), depression (<em>r</em> = −0.53), and somatic symptom severity (<em>r</em> = −0.36). The most desired types of psychological support included psychological counselling, spiritual support, and opportunities for rest.</div></div><div><h3>Conclusion</h3><div>It is essential to address the primary needs of HPs in Ukraine to support their professional and personal resilience during wartime. Psychological support should not only focus on treating symptoms and distress but also respond to deeper needs that foster hope and faith in a better future.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"188 ","pages":"Article 111995"},"PeriodicalIF":3.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart rate variability is not associated with multiple chemical sensitivity in a cross-sectional population-based study - The Danish study of functional disorders 在一项基于人群的横断面研究中，心率变异性与多重化学物质敏感性无关--丹麦功能性紊乱研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-11-19 DOI: 10.1016/j.jpsychores.2024.111992

Anne Ahrendt Bjerregaard , Louise Brinth , Marie W. Petersen , Signe U. Schovsbo , Lene Eplov , Susanne Brix , Allan Linneberg , Lise Gormsen , Torben Jørgensen , Thomas M. Dantoft

Objective

Multiple chemical sensitivity (MCS), a functional somatic disorder (FSD), is a multisystem, polysymptomatic disease, characterized by various individual symptoms attributed to low level of volatile chemical exposures. Symptoms relate to the autonomic nerve system (ANS) among others which is mandatory in the MCS delimitations. An accepted measure of ANS is heart rate variability (HRV). The aim was to explore associations between HRV and MCS in the general Danish population.

Methods

In the Danish Study of Functional Disorders, 7493 adults filled in questionnaires and participated in a physical health examination (2012–2015). The “E motion” heart rate monitor device assessed time and frequency measures of HRV. For this study, 143 were categorized with MCS of which, 84 were subcategorized as MCS without comorbid FSD. The remaining population (n = 5525) was used as comparison group. Logistic regression models to assess odds ratio (OR) with 95 % confidence intervals (95 % CI) of MCS, and MCS without comorbid FSD for each HRV exposure adjusted for age, sex, and chronic stress.

Results

Compared to the general population, median resting heart rate was higher (64.7 vs 63.1 bpm, p = 0.007) and median normal-to-normal intervals was lower (930 vs 952 ms, p = 0.007) in MCS individuals. Resting heart rate was associated with MCS (OR: 1.019, 95 %CI: 1.003; 1.037); but not after adjustment for chronic stress. No other associations with other HRV measures nor in MCS without comorbid FSD were found.

Conclusion

HRV was not associated with MCS. The magnitude of the differences between groups was small and of uncertain clinical significance.

目的：多重化学物质敏感症（MCS）是一种功能性躯体疾病（FSD），是一种多系统、多症状的疾病，其特征是因接触低水平挥发性化学物质而出现各种个体症状。症状主要与自律神经系统（ANS）有关，这也是界定 MCS 的必要条件。衡量自律神经系统的一个公认指标是心率变异性（HRV）。该研究旨在探讨丹麦普通人群中心率变异与 MCS 之间的关系：在丹麦功能障碍研究中，有 7493 名成年人填写了调查问卷并参加了身体健康检查（2012-2015 年）。E motion "心率监测设备评估了心率变异的时间和频率测量值。在这项研究中，143 人被归类为多发性硬化症患者，其中 84 人被细分为多发性硬化症患者，但不合并 FSD。其余人群（n = 5525）作为对比组。通过逻辑回归模型评估了MCS和无合并FSD的MCS与每种心率变异暴露的几率比（OR）及95%置信区间（95% CI），并对年龄、性别和慢性压力进行了调整：与普通人群相比，MCS 患者的中位静息心率更高（64.7 对 63.1 bpm，p = 0.007），中位正常与正常间期更低（930 对 952 ms，p = 0.007）。静息心率与多发性硬化症有关（OR：1.019，95 %CI：1.003; 1.037）；但在调整慢性压力后，与多发性硬化症无关。结论：心率变异与多发性硬化症无关：结论：心率变异与多发性硬化症无关。结论：心率变异与 MCS 无关，组间差异较小，临床意义不确定。

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引用次数: 0

Metabolomics profiling of Type D personality traits D 型人格特征的代谢组学分析。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-11-19 DOI: 10.1016/j.jpsychores.2024.111994

Ruifang Li-Gao , Mariska Bot , Alexander Kurilshikov , Gonneke Willemsen , Marleen M.J. van Greevenbroek , Miranda M.T. Schram , Coen D.A. Stehouwer , Jingyuan Fu , Alexandra Zhernakova , Brenda W.J.H. Penninx , Eco J.C. De Geus , Dorret I. Boomsma , Nina Kupper , for the BBMRI-NL Metabolomics Consortium

Objective

Type D (Distressed) personality combines negative affectivity (NA) and social inhibition (SI) and is associated with an increased risk of cardiometabolic diseases. Here, we examined the association of Type D traits with 230 (predominantly) lipid metabolites and metabolite ratios.

Methods

Four Dutch cohorts were included, comprising 10,834 individuals. Type D personality traits were measured by self-report questionnaires. A proton nuclear magnetic resonance (NMR) metabolomics platform provided 149 absolute measures (98 belonging to lipoprotein subclasses) and 81 derived ratios. For all, linear regression analyses were performed within each cohort, followed by random-effects meta-analyses. A per-measure FDR q-value<0.05 was set as a study-wise significant association.

Results

SI was significantly associated with a lower omega-3 fatty acids to total fatty acids (FAw3.FA%) ratio, and a lower free cholesterol to total lipids ratio in very small VLDL (XS.VLDL.FC%). FAw3.FA% was also associated to NA (no study-wise significance though). NA showed a suggestive replication (p-value<.05) of the previous reported associations with depression for 5 out of 18 metabolites from the same metabolomics platform: triglycerides in HDL, serum total triglycerides, VLDL cholesterol, mean diameter for VLDL particles and VLDL triglycerides.

Conclusions

In this large meta-analysis, SI was associated with omega-3 fatty acids to total fatty acids ratio, which is suggestive of lower omega-3 fatty acid intake. Only some metabolite biomarkers showed tentative links to Type D and NA. In sum, it seems that there are no major alterations in lipid metabolism associated with Type D traits.

目的D型（压抑型）人格结合了负性情感（NA）和社交抑制（SI），与心血管代谢疾病风险的增加有关。在此，我们研究了 D 型性格与 230 种（主要是）脂质代谢物和代谢物比率的关系：方法：纳入了四个荷兰队列，共 10834 人。D型人格特征通过自我报告问卷进行测量。质子核磁共振（NMR）代谢组学平台提供了 149 个绝对测量值（98 个属于脂蛋白亚类）和 81 个衍生比率。在每个队列中对所有数据进行线性回归分析，然后进行随机效应荟萃分析。每项测量的 FDR q 值结果：SI 与较低的ω-3 脂肪酸与总脂肪酸（FAw3.FA%）比率和较低的游离胆固醇与极小 VLDL 总脂类比率（XS.VLDL.FC%）明显相关。FAw3.FA%也与NA有关（但在研究上没有意义）。NA显示出提示性复制（p-value结论：在这项大型荟萃分析中，SI 与欧米伽-3 脂肪酸与总脂肪酸的比率有关，这表明欧米伽-3 脂肪酸的摄入量较低。只有一些代谢物生物标志物与 D 型和 NA 型有初步联系。总之，脂质代谢似乎没有与 D 型特征相关的重大改变。

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引用次数: 0

Clinical and metabolic correlates of DSM-5 mixed features in subjects with bipolar depression and mania: A cross-sectional study 双相抑郁和躁狂症患者中 DSM-5 混合特征的临床和代谢相关性：横断面研究

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-11-18 DOI: 10.1016/j.jpsychores.2024.111990

Francesco Bartoli, Daniele Cavaleri, Tommaso Callovini, Dario Palpella, Susanna Piacenti, Cristina Crocamo, Giuseppe Carrà, NOMIAC Investigators

Objective

Evidence on the clinical and metabolic characterization of mixed features (MFs) in bipolar disorder (BD) is limited. We performed a cross-sectional study analyzing clinical and metabolic correlates of MFs in people with bipolar depression or mania/hypomania.

Methods

We included people with BD consecutively admitted for inpatient treatment from May 2020 to July 2023 as part of the Northern Milan Area Cohort (NOMIAC) project. The SCID-5 was used to confirm the diagnosis and assess DSM-5 specifiers. Young Mania Rating Scale and Montgomery-Åsberg Depression Rating Scale were used to measure symptom severity. Information on socio-demographic, clinical, and metabolic conditions – including obesity, diabetes, hypertension, dyslipidemia, and hypothyroidism – were collected. Multiple logistic regression models were used to compare clinical and metabolic correlates between subjects with and without DSM-5 MFs.

Results

We included 163 inpatients with BD (111 admitted for a manic/hypomanic episode and 52 for a major depressive episode), 39 of whom with MFs. The overall logistic regression model showed that MFs were associated with anxious distress (z = 2.44; p = 0.015) and obesity (z = 2.39; p = 0.017), also being less frequent among moderately/markedly ill people as compared with those borderline/mildly ill (z = −2.71; p = 0.007). Additional analyses corroborated the association between MFs and these characteristics in people with a depressive episode, though not in those with mania/hypomania.

Conclusion

Notwithstanding some limitations, our study provides additional insight into the characterization of individuals with MFs, highlighting that anxious distress and symptom severity, along with obesity, may represent core features helpful for the assessment and management of MFs in BD.

目的有关双相情感障碍（BD）混合特征（MFs）的临床和代谢特征的证据有限。我们进行了一项横断面研究，分析了双相抑郁症或躁狂症/躁狂症患者混合特征的临床和代谢相关性。方法我们纳入了2020年5月至2023年7月期间连续住院治疗的双相情感障碍患者，他们是米兰北部地区队列（NOMIAC）项目的一部分。SCID-5用于确诊和评估DSM-5规范。杨氏躁狂评定量表和蒙哥马利-阿斯伯格抑郁评定量表用于测量症状严重程度。此外，还收集了有关社会人口学、临床和代谢状况（包括肥胖、糖尿病、高血压、血脂异常和甲状腺机能减退）的信息。结果我们纳入了 163 名 BD 住院患者（其中 111 人因躁狂/躁狂发作入院，52 人因重度抑郁发作入院），其中 39 人患有 MF。整体逻辑回归模型显示，MFs 与焦虑不安（z = 2.44；p = 0.015）和肥胖（z = 2.39；p = 0.017）有关，而且中度/明显患病者的发病率低于边缘/轻度患病者（z = -2.71；p = 0.007）。结论尽管存在一些局限性，但我们的研究为MFs患者的特征描述提供了更多的见解，强调了焦虑痛苦和症状严重程度以及肥胖可能是有助于评估和管理BD中MFs的核心特征。

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引用次数: 0

Strengthening cancer-spirituality research: A comprehensive analysis of methodological considerations in biomarker studies 加强癌症-精神研究：全面分析生物标志物研究中的方法考虑因素。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-11-17 DOI: 10.1016/j.jpsychores.2024.111991

Mahindra Bandari , Cindy Osei , Manisha Bandari

引用次数: 0