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Spatiotemporal co-occurrence and shared exposure profiles of adolescent depressive disorders and asthma worldwide and in China (GBD 2021, 1990–2021): an ecological study with bidirectional two-sample Mendelian randomization 全球和中国青少年抑郁症和哮喘的时空共现和共同暴露概况(GBD 2021, 1990-2021):双向双样本孟德尔随机化的生态学研究。
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-19 DOI: 10.1016/j.jpsychores.2026.112542
Xiaoxi Liu , Luhua Zhao , Wei Wu , Yonggui Yuan , Zhaojun Yan

Background

Depressive disorders and asthma frequently co-occur in adolescence, but global co-patterning and shared population-level risk signals remain unclear.

Methods

Using Global Burden of Disease (GBD) 2021 estimates for ages 10–19 years (1990–2021), we characterized global and China-specific trends and sex disparities in incidence, prevalence, and disability-adjusted life years (DALYs) using joinpoint regression. We constructed a 2021 incidence-quartile co-occurrence typology, estimated typology-stratified coupling (Spearman rank correlation coefficient, ρ) using pooled country–year observations (1990/2000/2011/2021), prioritized shared summary exposure value (SEV) correlates using Shapley additive explanations (SHAP)-informed multiclass random forests and negative binomial models, and evaluated bidirectional genetic directionality using two-sample Mendelian randomization (MR).

Results

The burden of depressive disorders remained broadly stable but started to increase from 2019 onward, with persistent female excess. Asthma DALY rates declined overall, whereas incidence and prevalence were largely stable globally, with modest recent increases in North America. In 2021, typology membership showed marked income gradients and positive within-typology coupling (ρ = 0.408–0.925). Ambient particulate matter ≤2.5 μm (PM2.5) and household air pollution from solid fuels were consistently prioritized as shared ecological correlates and showed marked socioeconomic gradients. Two-sample MR supported a modest depressive disorders-to-asthma signal (inverse-variance weighted (IVW) odds ratio (OR) = 1.18, 95% confidence interval (CI) 1.02–1.36), whereas reverse-direction estimates were weaker and more heterogeneous.

Conclusions

Adolescent depressive disorders and asthma exhibit divergent long-term trajectories but cluster into income-patterned co-occurrence typologies with shared ecological risk signals. These findings reflect population-level correlates and do not directly estimate intervention or policy effects.
背景:抑郁症和哮喘经常在青春期同时发生,但全球共同模式和共同的人群水平风险信号仍不清楚。方法:使用全球疾病负担(GBD) 2021年10-19岁(1990-2021)的估计值,我们使用联点回归分析了全球和中国特定的发病率、患病率和残疾调整生命年(DALYs)的趋势和性别差异。我们构建了2021年发病率-四分位数共发生的类型学,使用汇总的国家-年度观测(1990/2000/2011/2021)估计类型学-分层耦合(Spearman秩相关系数,ρ),使用Shapley加性解释(SHAP)通知的多类随机森林和负二项模型对共享总暴露值(SEV)相关性进行优先排序,并使用双样本孟德尔随机化(MR)评估双向遗传定向。结果:抑郁症的负担大致保持稳定,但从2019年开始增加,女性持续增加。哮喘DALY率总体下降,而全球发病率和流行率基本稳定,北美最近略有上升。在2021年,类型学成员表现出显著的收入梯度和正的类型学内部耦合(ρ = 0.408-0.925)。环境颗粒物≤2.5 μm (PM2.5)和固体燃料造成的家庭空气污染始终被优先考虑为共享的生态相关因素,并表现出明显的社会经济梯度。双样本MR支持适度的抑郁障碍-哮喘信号(反方差加权(IVW)优势比(OR) = 1.18, 95%置信区间(CI) 1.02-1.36),而反向估计较弱且异质性更强。结论:青少年抑郁症和哮喘表现出不同的长期发展轨迹,但聚集在收入模式的共发生类型中,具有共同的生态风险信号。这些发现反映了人口水平的相关性,并不能直接估计干预或政策的影响。
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引用次数: 0
Association between disability and alexithymia in lumbar disc herniation: A cross-sectional study 腰椎间盘突出症患者残疾与述情障碍之间的关系:一项横断面研究。
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-18 DOI: 10.1016/j.jpsychores.2026.112544
Kubra Neslihan Kurt Oktay , Ebru Yilmaz , Ismail Gunes Gokmen , Hudanur Coskun , Muhammet Sahin Elbasti , Osman Tufekci , Songul Ince , Emre Uzun , Duygu Geler Kulcu

Background

Lumbar disc herniation (LDH) is a common cause of low back pain (LBP) and disability. Psychosocial factors, including alexithymia, may influence patient-reported outcomes, but evidence in LDH remains limited. We examined associations among alexithymia, pain intensity, and disability in LDH.

Methods

In this cross-sectional study, 105 patients with LDH confirmed by clinical examination and magnetic resonance imaging (MRI) were assessed. Pain intensity was measured using the Visual Analog Scale (VAS), disability with the Oswestry Disability Index (ODI), and alexithymia with the 20-item Toronto Alexithymia Scale (TAS-20). Spearman correlations tested relationships between TAS-20 scores and demographic/clinical variables.

Results

Mean age was 51.6 ± 13.0 years; 66.7% were female. Possible/definite alexithymia was present in 39.0% (n = 41). BMI showed weak positive correlations with TAS-Difficulty Identifying Feelings (DIF), TAS-Externally Oriented Thinking (EOT), and TAS-total. Higher education and employment were weakly negatively correlated with TAS-DIF, TAS-Difficulty Describing Feelings (DDF), and TAS-total. Symptom duration showed weak inverse correlations with TAS scores. ODI showed weak positive correlations with TAS-DIF and TAS-total; VAS was not correlated with TAS scores. No significant associations were observed with age, sex, smoking, marital status, comorbidities, disc pathology, or neurological deficits.

Conclusions

Alexithymia is relatively common in LDH and shows weak associations with disability and selected sociodemographic factors but not pain intensity. These findings should not be interpreted as evidence of prediction or causality. Psychological assessment may help identify emotional processing difficulties and support comprehensive rehabilitation.
背景:腰椎间盘突出症(LDH)是下腰痛(LBP)和残疾的常见原因。包括述情障碍在内的社会心理因素可能影响患者报告的结果,但LDH的证据仍然有限。我们研究了LDH患者述情障碍、疼痛强度和残疾之间的关系。方法:对经临床检查和磁共振成像(MRI)证实的105例LDH患者进行横断面研究。采用视觉模拟量表(VAS)测量疼痛强度,采用Oswestry残疾指数(ODI)测量残疾,采用20项多伦多述情量表(TAS-20)测量述情。Spearman相关性测试了TAS-20分数与人口统计学/临床变量之间的关系。结果:平均年龄51.6±13.0岁;66.7%为女性。39.0% (n = 41)存在可能/明确的述情障碍。BMI与tas -情感识别困难(DIF)、tas -外向型思维(EOT)和tas -总分呈弱正相关。高等教育和就业与TAS-DIF、tas -描述感觉困难(DDF)和tas -总分呈弱负相关。症状持续时间与TAS评分呈弱负相关。ODI与TAS-DIF、TAS-total呈弱正相关;VAS与TAS评分无相关性。未观察到年龄、性别、吸烟、婚姻状况、合并症、椎间盘病理或神经功能缺损有显著相关性。结论:述情障碍在LDH中相对常见,与残疾和某些社会人口因素的相关性较弱,但与疼痛强度无关。这些发现不应被解释为预测或因果关系的证据。心理评估有助于识别情绪处理困难,支持全面康复。
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引用次数: 0
Symptom expectations as a clinical target in somatic symptom disorder: Cross-sectional evidence from the SOMA.SSD study 症状预期作为躯体症状障碍的临床靶点:来自SOMA的横断面证据。SSD的研究
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-16 DOI: 10.1016/j.jpsychores.2026.112546
Stefanie Hahn , Franz Pauls , Henrike Wittenbecher , Kerstin Maehder , Bernd Löwe , Kristina Blankenburg , Anne Toussaint , Yvonne Nestoriuc

Background

Symptom expectations influence symptom severity in patients with pain disorders through nocebo and placebo mechanisms. Similar associations have been suggested for patients with somatic symptom disorder (SSD). While evidence underlines the significance of expectations for symptom experience, yet little is known about the nature of these expectations in SSD or about the psychological and biological factors that shape them.

Methods

Patients diagnosed with SSD participated in a structured on-site assessment at the psychosomatic outpatient clinic of the University Medical Center Hamburg-Eppendorf. The assessment included standardized questionnaires, a physical examination, and a clinical interview. Descriptive statistics and multiple regression analyses were conducted on symptom impairment expectation and symptom-specific expectation measures.

Results

A total of N = 241 patients participated in this study. The majority of patients (66.8% female, mean age = 44.5 years) reported negative short-term symptom expectations (54%). Patients with more negative expectations also reported greater somatic symptom severity, higher depression and anxiety severity, increased symptom-related distress, and higher symptom-related disability. Symptom-related disability was found to have the largest association with symptom impairment expectations (short-term: β = 0.46, p < 0.001, long-term: β = 0.26, p < 0.001), whereas symptom severity was associated with symptom-specific expectations the most (β = 0.66, p < 0.001).

Conclusion

Negative symptom expectations are associated with elevated psychological burden in patients with SSD, indicating a clinically relevant subgroup that may benefit from expectation-focused interventions.
背景:症状预期通过反安慰剂和安慰剂机制影响疼痛障碍患者的症状严重程度。躯体症状障碍(SSD)患者也存在类似的关联。虽然证据强调了对症状体验的期望的重要性,但对SSD中这些期望的性质或形成它们的心理和生物因素知之甚少。方法在汉堡-埃彭多夫大学医学中心心身门诊对诊断为SSD的患者进行结构化的现场评估。评估包括标准化问卷、体格检查和临床访谈。对症状损害期望和症状特异性期望测度进行描述性统计和多元回归分析。结果共纳入N = 241例患者。大多数患者(66.8%为女性,平均年龄为44.5岁)报告了负面的短期症状预期(54%)。负面期望越高的患者也报告了更严重的躯体症状,更高的抑郁和焦虑严重程度,增加的症状相关的痛苦,以及更高的症状相关的残疾。研究发现,症状相关残疾与症状损害预期的相关性最大(短期:β = 0.46, p < 0.001,长期:β = 0.26, p < 0.001),而症状严重程度与症状特异性预期的相关性最大(β = 0.66, p < 0.001)。结论:负面症状预期与SSD患者心理负担升高相关,表明临床相关亚组可能受益于以预期为重点的干预措施。
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引用次数: 0
Prevalence and factors influencing cognitive impairment among older adult stroke survivors in Taiwan: A national cross-sectional study 台湾老年脑卒中幸存者认知障碍患病率及影响因素:一项全国性横断面研究。
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-15 DOI: 10.1016/j.jpsychores.2026.112541
Shu-Chun Lee , Hsiang-Ru Lai , Pei-I Lee , Henny Dwi Susanti , Yu-Lin Wu , Pi-Hsia Lee

Background

Stroke survivors may experience cognitive impairment, which can seriously affect their lives and increase the burdens of main caregivers. Factors affecting cognitive impairment in stroke survivors are less well investigated nationally.

Aims

This study estimated the prevalence of and applied a biopsychosocial framework to explore physiological, psychological, and social factors influencing cognitive impairment among older adult stroke survivors in Taiwan.

Methods

This was a secondary data analysis study using a database from the Taiwan Longitudinal Study on Aging, a population-based survey. Potential risk factors of cognitive impairment in stroke survivors included demographic characteristics, chronic diseases, oral health problems, basic activities of daily living (ADLs), instrumental ADLs (IADLs), weekly exercise behavior, depression, and emotional support. Logistic multiple regression analysis was used to analyze the data.

Results

Among 495 stroke survivors, 222 participants were experiencing cognitive impairment, for a prevalence rate of 44.9%. The results showed that the higher the oral health problems score (odds ratio [OR]: 1.09, p = .003) and the IADL score (OR: 1.19, p < .001) were associated with increased risk of cognitive impairment.
By contrast, a higher emotional support score was associated with a lower cognitive impairment risk (OR: 0.74, p = .008).

Conclusion

Stroke patients are predisposed to cognitive impairment. This study highlights the importance of maintaining oral health, promoting IADLs, and providing emotional support to prevent cognitive impairment in stroke survivors.
背景:脑卒中幸存者可能经历认知障碍,这可能严重影响他们的生活,并增加主要照顾者的负担。影响中风幸存者认知障碍的因素在全国范围内调查较少。目的:本研究评估台湾老年脑卒中幸存者认知障碍的患病率,并应用生物心理社会框架探讨影响认知障碍的生理、心理及社会因素。方法:本研究为二次资料分析研究,采用台湾人口老龄化纵向研究数据库。脑卒中幸存者认知功能障碍的潜在危险因素包括人口统计学特征、慢性疾病、口腔健康问题、基本日常生活活动(ADLs)、辅助日常生活活动(IADLs)、每周运动行为、抑郁和情感支持。采用Logistic多元回归分析对数据进行分析。结果:在495名中风幸存者中,222名参与者出现认知障碍,患病率为44.9%。结果显示,口腔健康问题评分(比值比[OR]: 1.09, p = 0.003)和IADL评分(比值比[OR]: 1.19, p)越高,脑卒中患者易发生认知功能障碍。这项研究强调了维持口腔健康、促进iadl和提供情感支持对预防脑卒中幸存者认知障碍的重要性。
{"title":"Prevalence and factors influencing cognitive impairment among older adult stroke survivors in Taiwan: A national cross-sectional study","authors":"Shu-Chun Lee ,&nbsp;Hsiang-Ru Lai ,&nbsp;Pei-I Lee ,&nbsp;Henny Dwi Susanti ,&nbsp;Yu-Lin Wu ,&nbsp;Pi-Hsia Lee","doi":"10.1016/j.jpsychores.2026.112541","DOIUrl":"10.1016/j.jpsychores.2026.112541","url":null,"abstract":"<div><h3>Background</h3><div>Stroke survivors may experience cognitive impairment, which can seriously affect their lives and increase the burdens of main caregivers. Factors affecting cognitive impairment in stroke survivors are less well investigated nationally.</div></div><div><h3>Aims</h3><div>This study estimated the prevalence of and applied a biopsychosocial framework to explore physiological, psychological, and social factors influencing cognitive impairment among older adult stroke survivors in Taiwan.</div></div><div><h3>Methods</h3><div>This was a secondary data analysis study using a database from the Taiwan Longitudinal Study on Aging, a population-based survey. Potential risk factors of cognitive impairment in stroke survivors included demographic characteristics, chronic diseases, oral health problems, basic activities of daily living (ADLs), instrumental ADLs (IADLs), weekly exercise behavior, depression, and emotional support. Logistic multiple regression analysis was used to analyze the data.</div></div><div><h3>Results</h3><div>Among 495 stroke survivors, 222 participants were experiencing cognitive impairment, for a prevalence rate of 44.9%. The results showed that the higher the oral health problems score (odds ratio [OR]: 1.09, <em>p</em> = .003) and the IADL score (OR: 1.19, <em>p &lt;</em> .001) were associated with increased risk of cognitive impairment.</div><div>By contrast, a higher emotional support score was associated with a lower cognitive impairment risk (OR: 0.74, <em>p =</em> .008).</div></div><div><h3>Conclusion</h3><div>Stroke patients are predisposed to cognitive impairment. This study highlights the importance of maintaining oral health, promoting IADLs, and providing emotional support to prevent cognitive impairment in stroke survivors.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112541"},"PeriodicalIF":3.3,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146012982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Comment on “Biopsychosocial risk factors for the transition from acute to chronic back pain: A prospective cohort study” 回复“从急性到慢性背痛转变的生物心理社会风险因素:一项前瞻性队列研究”评论。
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-14 DOI: 10.1016/j.jpsychores.2026.112543
Petra Engelmann, Mareike Busmann, Bernd Löwe, Paul Hüsing
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引用次数: 0
Alexithymia is associated with higher pain ratings and greater pressure pain tolerance in adolescents with major depressive disorder: Evidence consistent with sensory-affective dissociation 患有重度抑郁症的青少年述情障碍与更高的疼痛评分和更大的压力疼痛耐受性有关:与感觉-情感分离一致的证据
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-13 DOI: 10.1016/j.jpsychores.2026.112538
Qing Zhang , Jingwen Shang , Jinyue Xue , Qingqing Shen , Yudong Shi , Zhichun Liu , Zhiwei Liu , Liang Sun , Kai Zhang , Huanzhong Liu

Objective

To examine associations of alexithymia with subjective pain intensity and pressure pain tolerance in adolescents with major depressive disorder (MDD), and to test whether alexithymia shows indirect effects linking depressive severity with these pain outcomes in cross-sectional models.

Methods

193 adolescents with MDD completed the Hamilton Depression Rating Scale (HAMD) and Toronto Alexithymia Scale-20 (TAS-20). Subjective pain intensity was rated with the NRS-11. Experimental pain indicators included pressure pain threshold (PPT) and pressure pain tolerance (PTO).

Results

Pain intensity was associated with HAMD (OR = 1.054, P = 0.010) and TAS-20 (OR = 1.045, P = 0.008). TAS-20 was associated with higher pain tolerance (PTO-1: B = 0.003, P = 0.014; PTO-2: B = 0.004, P = 0.021). Depressive severity was associated with alexithymia (P < 0.001). Indirect effects via alexithymia were significant for tolerance with nonsignificant direct effects (both P < 0.05). For pain intensity, both the direct effect (0.247, P = 0.001) and the indirect effect (0.064, P < 0.05) were significant, with the indirect effect accounting for 20.7% of the total effect.

Conclusion

Alexithymia is associated with altered pain perception in adolescents with MDD and may statistically account for part of the association between depressive severity and pain outcomes. The pattern is consistent with sensory-affective dissociation and supports considering emotional processing difficulties when assessing and managing pain complaints in depressed adolescents.
目的研究重度抑郁症(MDD)青少年述情障碍与主观疼痛强度和压力疼痛耐受性的关系,并在横截面模型中检验述情障碍是否表现出抑郁严重程度与这些疼痛结果之间的间接影响。方法对193例MDD青少年进行汉密尔顿抑郁评定量表(HAMD)和多伦多述情障碍量表-20 (TAS-20)的测试。主观疼痛强度用NRS-11评分。实验疼痛指标包括压痛阈值(PPT)和压痛耐受性(PTO)。结果西班牙强度与HAMD (OR = 1.054, P = 0.010)、TAS-20 (OR = 1.045, P = 0.008)相关。TAS-20与较高的疼痛耐受性相关(PTO-1: B = 0.003, P = 0.014; PTO-2: B = 0.004, P = 0.021)。抑郁严重程度与述情障碍相关(P < 0.001)。通过述情障碍产生的间接影响对耐受性显著,直接影响不显著(P < 0.05)。对于疼痛强度,直接效应(0.247,P = 0.001)和间接效应(0.064,P < 0.05)均显著,间接效应占总效应的20.7%。结论青少年重度抑郁症患者的述情障碍与痛觉改变有关,可能是抑郁严重程度与疼痛结局之间部分关联的统计学原因。该模式与感觉-情感分离一致,并支持在评估和管理抑郁青少年的疼痛主诉时考虑情绪处理困难。
{"title":"Alexithymia is associated with higher pain ratings and greater pressure pain tolerance in adolescents with major depressive disorder: Evidence consistent with sensory-affective dissociation","authors":"Qing Zhang ,&nbsp;Jingwen Shang ,&nbsp;Jinyue Xue ,&nbsp;Qingqing Shen ,&nbsp;Yudong Shi ,&nbsp;Zhichun Liu ,&nbsp;Zhiwei Liu ,&nbsp;Liang Sun ,&nbsp;Kai Zhang ,&nbsp;Huanzhong Liu","doi":"10.1016/j.jpsychores.2026.112538","DOIUrl":"10.1016/j.jpsychores.2026.112538","url":null,"abstract":"<div><h3>Objective</h3><div>To examine associations of alexithymia with subjective pain intensity and pressure pain tolerance in adolescents with major depressive disorder (MDD), and to test whether alexithymia shows indirect effects linking depressive severity with these pain outcomes in cross-sectional models.</div></div><div><h3>Methods</h3><div>193 adolescents with MDD completed the Hamilton Depression Rating Scale (HAMD) and Toronto Alexithymia Scale-20 (TAS-20). Subjective pain intensity was rated with the NRS-11. Experimental pain indicators included pressure pain threshold (PPT) and pressure pain tolerance (PTO).</div></div><div><h3>Results</h3><div>Pain intensity was associated with HAMD (OR = 1.054, <em>P</em> = 0.010) and TAS-20 (OR = 1.045, <em>P</em> = 0.008). TAS-20 was associated with higher pain tolerance (PTO-1: B = 0.003, <em>P</em> = 0.014; PTO-2: B = 0.004, <em>P</em> = 0.021). Depressive severity was associated with alexithymia (<em>P</em> &lt; 0.001). Indirect effects via alexithymia were significant for tolerance with nonsignificant direct effects (both <em>P</em> &lt; 0.05). For pain intensity, both the direct effect (0.247, <em>P</em> = 0.001) and the indirect effect (0.064, <em>P</em> &lt; 0.05) were significant, with the indirect effect accounting for 20.7% of the total effect.</div></div><div><h3>Conclusion</h3><div>Alexithymia is associated with altered pain perception in adolescents with MDD and may statistically account for part of the association between depressive severity and pain outcomes. The pattern is consistent with sensory-affective dissociation and supports considering emotional processing difficulties when assessing and managing pain complaints in depressed adolescents.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112538"},"PeriodicalIF":3.3,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Number of group psychotherapy sessions predicts inflammation changes in patients with coronary artery disease and comorbid depression 团体心理治疗次数可预测冠状动脉疾病和共病抑郁症患者的炎症变化。
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-12 DOI: 10.1016/j.jpsychores.2026.112539
Joram Ronel , Elisabeth Olliges , Christoph Herrmann-Lingen , Christian Albus , Birgitt Marten-Mittag , Siegmund L. Braun , Hans Christian Deter , Marie-Christine Federle , Katharina Franz , Kurt Fritzsche , Jana Jünger , Matthias Michal , Lena Schambeck , Roland Schmidt , Wolfgang Söllner , Frank Vitinius , Cora S. Weber , Martina de Zwaan , Katja Petrowski , Karl-Heinz Ladwig

Objective

Inflammation contributes to the bidirectional relationship between depression and coronary artery disease (CAD). However, the impact of group psychotherapy on inflammatory levels in CAD patients with comorbid depression has not been elucidated.

Methods

A total of 337 patients (average age 59.2 years ±9.4, 80.4% male) from the SPIRR-CAD trial provided results of questionnaires and inflammatory data at baseline (T0) and the 18-month follow-up (T3) of a group psychotherapy program, with a maximum of 25 sessions vs. usual care.

Results

At baseline, inflammatory parameters were elevated for high-sensitivity C-reactive protein (hsCRP) in 41.2%, tumor necrosis factor-α (TNF-α) in 33.2% and interleukin-6 (IL-6) in 21.1% of all patients. From T0 to T3, prevalences of elevated hsCRP (p = .027), TNF-α (p = .013) and depression scores (measured with the Hamilton Depression Rating-Scale; (p = .002) significantly decreased in all patients. Additionally, an inflammatory factors score (IFS), calculated from the inflammatory parameters showed a significant decrease between T0 and T3 (p = .046) in all patients. A blockwise multivariate logistic regression analysis revealed a 4.59-fold higher chance of IFS reduction (or stable low values) for patients with a higher number (10–25) of group psychotherapy sessions (OR = 4.59, 95% CI: 1.39–15.1, p = .012) compared to patients with 1–9 sessions, even after adjusting for comorbidities or pharmacological antidepressant treatment.

Conclusion

This analysis demonstrates a significant impact of group psychotherapy sessions on IFS changes in CAD patients with persistently elevated depression scores. Beyond the influence of the absence of diabetes mellitus, a higher number of group psychotherapy sessions reduces the risk of inflammatory burden.
目的:炎症参与抑郁与冠状动脉疾病(CAD)的双向关系。然而,团体心理治疗对冠心病合并抑郁症患者炎症水平的影响尚未得到阐明。方法:来自SPIRR-CAD试验的337例患者(平均年龄59.2岁±9.4岁,80.4%为男性)提供了基线(T0)和团体心理治疗项目18个月随访(T3)的问卷调查结果和炎症数据,与常规治疗相比,最多25次。结果:基线时,41.2%的患者高敏c反应蛋白(hsCRP)、33.2%的患者肿瘤坏死因子-α (TNF-α)和21.1%的患者白细胞介素-6 (IL-6)的炎症参数升高。从T0到T3,所有患者的hsCRP (p = 0.027)、TNF-α (p = 0.013)和抑郁评分(用汉密尔顿抑郁评定量表测量;p = 0.002)升高的患病率均显著降低。此外,根据炎症参数计算的炎症因子评分(IFS)显示,所有患者在T0和T3之间均显着下降(p = 0.046)。一项分段多因素logistic回归分析显示,与接受1-9次小组心理治疗的患者相比,接受较多小组心理治疗(10-25次)的患者(or = 4.59, 95% CI: 1.39-15.1, p = 0.012) IFS降低(或稳定低值)的机会高出4.59倍,即使在调整了合共病或药物抗抑郁治疗后也是如此。结论:本分析表明,团体心理治疗对抑郁评分持续升高的CAD患者的IFS变化有显著影响。除了没有糖尿病的影响外,更多的团体心理治疗会议减少了炎症负担的风险。
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引用次数: 0
The interplay between benefit finding and quality of life in maintenance hemodialysis patients: A cross-sectional network analysis 维持性血液透析患者的获益发现与生活质量之间的相互作用:横断面网络分析
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-11 DOI: 10.1016/j.jpsychores.2026.112533
Shuang Zhou , Zhiwu Tian , Qin Wu , Fuzhen Li , Hongmei Tao , Meifang Mai , Meifen Zhang

Objective

Maintenance hemodialysis (MHD) patients experience significant impacts on their quality of life (QoL). Benefit finding (BF) may influence QoL, but the specific structural relationships between BF dimensions and QoL domains remain unclear. The aim of this study was to identify core components of BF and QoL networks and bridging pathways linking them in MHD patients.

Methods

A cross-sectional study was conducted among 290 MHD patients from a tertiary hospital in China (January–June 2021). BF was assessed using the 22-item Benefit Finding Scale, and QoL was measured with the KDQOL-36™. Network analysis was employed to construct the BF-QoL network, estimate node centrality (strength, closeness, betweenness), and identify bridge connections. Stability was assessed using bootstrap methods (1000 samples).

Results

The BF network identified Personal Growth (strength = 2.367) as the most central node. In the QoL network, Effects of Kidney Disease (strength = 0.558) was central. Between-network analysis revealed Acceptance and Mental Composite Score as critical bridge nodes (highest betweenness: 1.592 and 1.298, respectively). Significant edges connected Acceptance to Mental Composite Score (r = 0.134, P < 0.05) and Health Behaviors to Physical Composite Score (r = 0.119, P < 0.05). Network sparsity was 0.4. Centrality stability was robust (correlation-stability coefficient > 0.5 for strength/closeness).

Conclusion

BF and QoL form an interconnected network in MHD patients. Personal Growth and Effects of Kidney Disease are central to their respective constructs, while Acceptance and mental health bridge BF and QoL. Interventions targeting these core nodes may optimize multidimensional QoL outcomes.
目的探讨维持性血液透析(MHD)对患者生活质量的影响。效益发现(BF)可能影响生活质量,但BF维度与生活质量领域之间的具体结构关系尚不清楚。本研究的目的是确定MHD患者BF和QoL网络的核心组成部分以及连接它们的桥接通路。方法对国内某三级医院290例MHD患者(2021年1月- 6月)进行横断面研究。使用22项效益发现量表评估BF,使用KDQOL-36™测量生活质量。网络分析用于构建BF-QoL网络,估计节点的中心性(强度、紧密度、中间度),并识别桥梁连接。稳定性评估采用自举法(1000个样本)。结果BF网络以个人成长(强度= 2.367)为最中心节点。在生活质量网络中,肾脏疾病的影响(强度= 0.558)是中心。网络间分析显示,接受度和心理综合得分是关键的桥梁节点(最高的网络间度分别为1.592和1.298)。接受度与心理综合得分(r = 0.134, P < 0.05)、健康行为与身体综合得分(r = 0.119, P < 0.05)相关。网络稀疏度为0.4。中心性稳定性是稳健的(强度/接近度的相关稳定性系数>; 0.5)。结论MHD患者的生活质量与生活质量是一个相互联系的网络。个人成长和肾脏疾病的影响是各自结构的中心,而接受和心理健康是BF和QoL的桥梁。针对这些核心节点的干预措施可以优化多维生活质量结果。
{"title":"The interplay between benefit finding and quality of life in maintenance hemodialysis patients: A cross-sectional network analysis","authors":"Shuang Zhou ,&nbsp;Zhiwu Tian ,&nbsp;Qin Wu ,&nbsp;Fuzhen Li ,&nbsp;Hongmei Tao ,&nbsp;Meifang Mai ,&nbsp;Meifen Zhang","doi":"10.1016/j.jpsychores.2026.112533","DOIUrl":"10.1016/j.jpsychores.2026.112533","url":null,"abstract":"<div><h3>Objective</h3><div>Maintenance hemodialysis (MHD) patients experience significant impacts on their quality of life (QoL). Benefit finding (BF) may influence QoL, but the specific structural relationships between BF dimensions and QoL domains remain unclear. The aim of this study was to identify core components of BF and QoL networks and bridging pathways linking them in MHD patients.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted among 290 MHD patients from a tertiary hospital in China (January–June 2021). BF was assessed using the 22-item Benefit Finding Scale, and QoL was measured with the KDQOL-36™. Network analysis was employed to construct the BF-QoL network, estimate node centrality (strength, closeness, betweenness), and identify bridge connections. Stability was assessed using bootstrap methods (1000 samples).</div></div><div><h3>Results</h3><div>The BF network identified Personal Growth (strength = 2.367) as the most central node. In the QoL network, Effects of Kidney Disease (strength = 0.558) was central. Between-network analysis revealed Acceptance and Mental Composite Score as critical bridge nodes (highest betweenness: 1.592 and 1.298, respectively). Significant edges connected Acceptance to Mental Composite Score (<em>r</em> = 0.134, <em>P</em> &lt; 0.05) and Health Behaviors to Physical Composite Score (<em>r</em> = 0.119, <em>P</em> &lt; 0.05). Network sparsity was 0.4. Centrality stability was robust (correlation-stability coefficient &gt; 0.5 for strength/closeness).</div></div><div><h3>Conclusion</h3><div>BF and QoL form an interconnected network in MHD patients. Personal Growth and Effects of Kidney Disease are central to their respective constructs, while Acceptance and mental health bridge BF and QoL. Interventions targeting these core nodes may optimize multidimensional QoL outcomes.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112533"},"PeriodicalIF":3.3,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emotional outcomes are poorer in adults with developmental coordination disorder: A systematic review and meta-analyses 成人发育性协调障碍患者的情绪结果较差:一项系统回顾和荟萃分析。
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-11 DOI: 10.1016/j.jpsychores.2026.112537
Jorge Lopes Cavalcante-Neto , Matthew Bourke , João Mateus Carneiro Silva , John Cairney

Background

Evidence of the relationship between emotional problems and developmental coordination disorder (DCD) in adulthood remains scarce. The aim was to conduct a systematic review and meta-analysis to compare emotional outcomes in adults with and without DCD, controlling for outcome type, age and method of DCD identification.

Methods

Emotional outcomes were categorised into five categories: (i) anxiety; (ii) depression; (iv) psychological domain of quality of life; (v) stress, and (vi) subjective wellbeing. The Newcastle-Ottawa Quality Assessment Scale (NOS) assessed study quality. Cluster robust variance meta-analyses estimated a pooled standardized mean difference in emotional problems between adults with and without DCD. Subgroup analyses determined if effect sizes differed between outcome types, age groups and the method of DCD identification.

Results

From 5025 retrieved articles, 12 met the inclusion criteria. From these articles, 1890 participants (1025 with DCD and 865 with TD), aged 18–66 years, were included in the meta-analysis. No studies were classified as high quality, though most were of moderate quality (8/12). Adults with DCD reported significantly more emotional symptoms (SMD = 0.79, 95%CI = 0.51, 1.07) than their peers. Large effects sizes were maintained after excluding low quality studies and controlling for age, outcomes, and DCD identification method.

Conclusion

This review highlights the burden of emotional outcomes problems in adults with DCD and may support the identification of the condition in adulthood, as high levels of anxiety, depression, and stress, along with low psychological quality of life and self-esteem, are key features associated with the condition in this population.
背景:成年期情绪问题与发育性协调障碍(DCD)之间关系的证据仍然很少。目的是进行系统回顾和荟萃分析,比较患有和不患有DCD的成年人的情绪结果,控制结果类型,年龄和DCD识别方法。方法:将情绪结局分为5类:(i)焦虑;(2)抑郁;生活质量的心理领域;(v)压力;(vi)主观幸福感。纽卡斯尔-渥太华质量评估量表(NOS)评估研究质量。聚类稳健性方差荟萃分析估计了有和没有DCD的成年人在情绪问题上的标准化平均差异。亚组分析确定结果类型、年龄组和DCD鉴定方法之间的效应大小是否不同。结果:在5025篇检索文章中,有12篇符合纳入标准。从这些文章中,1890名参与者(1025名DCD患者和865名TD患者),年龄在18-66岁,被纳入meta分析。没有研究被归类为高质量,尽管大多数是中等质量(8/12)。患有DCD的成年人报告的情绪症状明显多于同龄人(SMD = 0.79, 95%CI = 0.51, 1.07)。在排除低质量研究并控制年龄、结局和DCD识别方法后,仍保持较大的效应量。结论:本综述强调了成年DCD患者的情绪结局问题负担,并可能支持成年后对该疾病的识别,因为高水平的焦虑、抑郁和压力,以及低心理生活质量和自尊,是该人群中与该疾病相关的关键特征。
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引用次数: 0
The association between sleep trajectories throughout pregnancy and postpartum pain in individuals with overweight or obesity: A prospective cohort study 孕期睡眠轨迹与超重或肥胖患者产后疼痛的关系:一项前瞻性队列研究
IF 3.3 2区 医学 Q2 PSYCHIATRY Pub Date : 2026-01-09 DOI: 10.1016/j.jpsychores.2026.112535
Marquis S. Hawkins , Danielle A.N. Chapa , Grace Lim , Andrea B. Goldschmidt , Michelle L. Meyer , Forgive Avorgbedor , Michele D. Levine
Background: Pain after childbirth impacts maternal and infant outcomes. While sleep affects pain in adult populations, research during the perinatal period is limited. This study examines the association between sleep quality and duration before delivery and throughout pregnancy with pain during postpartum hospitalization. Methods: This analysis included 118 pregnant individuals with a pre-pregnancy BMI ≥ 25 kg/m2. Group-based trajectory models identified patterns of self-reported sleep quality and duration at six prenatal visits. Pain was assessed every 8 h during the three-day postpartum hospitalization using a 0–10 numeric rating scale. The Area Under the Curve (AUC) for these assessments reflects cumulative pain burden; log-transformed AUC, exponentiated for interpretation. Linear regression analyzed the relationship between sleep (trajectories and before pregnancy) and cumulative pain burden. Results: Two trajectories for sleep quality and two for sleep duration were identified. The “Consistently poor” group showed increasing PSQI scores from 9 to 11, while the “Late worsening” group's scores increased from 4 to 6. The “Late decreasing” duration group consistently slept 6–7 h, while the “Consistently short” group maintained 5–6 h nightly. No statistically significant associations were found between sleep quality (expβ = 0.70, 95% CI: 0.45 to 1.10) or sleep duration trajectories (expβ = 0.68, 95% CI: 0.41 to 1.13) throughout pregnancy and cumulative pain burden. Conclusions: Sleep quality and duration changes during pregnancy were not associated with postpartum pain in this cohort. Future research should explore sleep's impact on pain later in the postpartum period when chronic pain may develop.
背景:分娩后疼痛影响母婴结局。虽然睡眠会影响成年人的疼痛,但对围产期的研究有限。本研究探讨了分娩前和整个孕期睡眠质量与产后住院期间疼痛之间的关系。方法:本研究纳入118例孕前BMI≥25 kg/m2的孕妇。基于群体的轨迹模型确定了六次产前检查中自我报告的睡眠质量和持续时间的模式。在产后3天住院期间,每8小时用0-10数值评定量表评估疼痛。这些评估的曲线下面积(AUC)反映了累积疼痛负担;对数变换的AUC,取幂以便解释。线性回归分析了睡眠(轨迹和孕前)与累积疼痛负担的关系。结果:确定了两条睡眠质量轨迹和两条睡眠持续时间轨迹。“持续贫穷”组的PSQI得分从9分上升到11分,而“晚期恶化”组的得分从4分上升到6分。持续时间“晚减”组每晚睡眠6-7小时,而“持续短”组每晚睡眠5-6小时。妊娠期间的睡眠质量(expβ = 0.70, 95% CI: 0.45 ~ 1.10)或睡眠持续时间轨迹(expβ = 0.68, 95% CI: 0.41 ~ 1.13)与累积疼痛负担之间没有统计学上的显著关联。结论:在这个队列中,怀孕期间睡眠质量和持续时间的变化与产后疼痛无关。未来的研究应该探索睡眠对产后后期疼痛的影响,因为后期可能会出现慢性疼痛。
{"title":"The association between sleep trajectories throughout pregnancy and postpartum pain in individuals with overweight or obesity: A prospective cohort study","authors":"Marquis S. Hawkins ,&nbsp;Danielle A.N. Chapa ,&nbsp;Grace Lim ,&nbsp;Andrea B. Goldschmidt ,&nbsp;Michelle L. Meyer ,&nbsp;Forgive Avorgbedor ,&nbsp;Michele D. Levine","doi":"10.1016/j.jpsychores.2026.112535","DOIUrl":"10.1016/j.jpsychores.2026.112535","url":null,"abstract":"<div><div><u>Background</u>: Pain after childbirth impacts maternal and infant outcomes. While sleep affects pain in adult populations, research during the perinatal period is limited. This study examines the association between sleep quality and duration before delivery and throughout pregnancy with pain during postpartum hospitalization. <u>Methods</u>: This analysis included 118 pregnant individuals with a pre-pregnancy BMI ≥ 25 kg/m<sup>2</sup>. Group-based trajectory models identified patterns of self-reported sleep quality and duration at six prenatal visits. Pain was assessed every 8 h during the three-day postpartum hospitalization using a 0–10 numeric rating scale. The Area Under the Curve (AUC) for these assessments reflects cumulative pain burden; log-transformed AUC, exponentiated for interpretation. Linear regression analyzed the relationship between sleep (trajectories and before pregnancy) and cumulative pain burden. <u>Results</u>: Two trajectories for sleep quality and two for sleep duration were identified. The “Consistently poor” group showed increasing PSQI scores from 9 to 11, while the “Late worsening” group's scores increased from 4 to 6. The “Late decreasing” duration group consistently slept 6–7 h, while the “Consistently short” group maintained 5–6 h nightly. No statistically significant associations were found between sleep quality (expβ = 0.70, 95% CI: 0.45 to 1.10) or sleep duration trajectories (expβ = 0.68, 95% CI: 0.41 to 1.13) throughout pregnancy and cumulative pain burden. <u>Conclusions</u>: Sleep quality and duration changes during pregnancy were not associated with postpartum pain in this cohort. Future research should explore sleep's impact on pain later in the postpartum period when chronic pain may develop.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"203 ","pages":"Article 112535"},"PeriodicalIF":3.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Psychosomatic Research
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