Pub Date : 2024-09-08DOI: 10.1016/j.jpsychores.2024.111926
Dejan Stevanovic , Nikola Cirovic
{"title":"From a general p to a transdiagnostic d and beyond: what is an underlying factor of youth mental and physical health comorbidities?","authors":"Dejan Stevanovic , Nikola Cirovic","doi":"10.1016/j.jpsychores.2024.111926","DOIUrl":"10.1016/j.jpsychores.2024.111926","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111926"},"PeriodicalIF":3.5,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study explores the mental health situation in Kosova and the impact of the COVID-19 pandemic.
Methods
Marketed quantities of antidepressants (N06A) and anxiolytics (N05B) from 2017 to 2022 were analyzed using the Anatomical Therapeutic Chemical/Defined Daily Doses (ATC/DDD) methodology. Caution is advised as these quantities may not directly reflect patient usage and could include uses for conditions outside their primary indications.
Results
Prior to the pandemic, antidepressant quantities remained relatively stable, but rose from 6.8 DDD/1000 inhabitants/day in 2019 to 9.7 in 2020 and 12.4 in 2021, before returning to pre-pandemic levels of 6.8 DDD in 2022. Over 80 % of these were selective serotonin reuptake inhibitors. Meanwhile, anxiolytic quantities initially decreased from 17.4 DDD in 2017 to 9.9 in 2019, then rebounded to 17.9 DDD in 2020. Notably, alprazolam usage surged from 2.9 in 2017 to 6.9 in 2021, subsequently dropping to 2.0 in 2022.
Conclusions
The volatile trends in medication quantities during the pandemic suggest a fragile mental health landscape in Kosova—a developing, post-conflict country with a youthful population—underscoring the need for proactive interventions in similar contexts globally.
{"title":"Mental health landscape in Kosova from 2017 to 2022: A retrospective study of antidepressant and anxiolytic market trends and the impact of COVID-19","authors":"Ardian Rugova , Manushaqe Kryeziu-Rrahmani , Genta Jahiu , Nazim Dakaj , Fehmi Rrahmani , Nderim Kryeziu","doi":"10.1016/j.jpsychores.2024.111927","DOIUrl":"10.1016/j.jpsychores.2024.111927","url":null,"abstract":"<div><h3>Objectives</h3><p>This study explores the mental health situation in Kosova and the impact of the COVID-19 pandemic.</p></div><div><h3>Methods</h3><p>Marketed quantities of antidepressants (N06A) and anxiolytics (N05B) from 2017 to 2022 were analyzed using the Anatomical Therapeutic Chemical/Defined Daily Doses (ATC/DDD) methodology. Caution is advised as these quantities may not directly reflect patient usage and could include uses for conditions outside their primary indications.</p></div><div><h3>Results</h3><p>Prior to the pandemic, antidepressant quantities remained relatively stable, but rose from 6.8 DDD/1000 inhabitants/day in 2019 to 9.7 in 2020 and 12.4 in 2021, before returning to pre-pandemic levels of 6.8 DDD in 2022. Over 80 % of these were selective serotonin reuptake inhibitors. Meanwhile, anxiolytic quantities initially decreased from 17.4 DDD in 2017 to 9.9 in 2019, then rebounded to 17.9 DDD in 2020. Notably, alprazolam usage surged from 2.9 in 2017 to 6.9 in 2021, subsequently dropping to 2.0 in 2022.</p></div><div><h3>Conclusions</h3><p>The volatile trends in medication quantities during the pandemic suggest a fragile mental health landscape in Kosova—a developing, post-conflict country with a youthful population—underscoring the need for proactive interventions in similar contexts globally.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111927"},"PeriodicalIF":3.5,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-04DOI: 10.1016/j.jpsychores.2024.111913
Jiatong Cui , Guiqin Zhang , Yunyan Xianyu , Xiaohong Zhang , Yu Xin Cheng , Yu Jia Liu , Wei Xiong , Wei Liu , Qian Liu , Bing Xiang Yang , Huijing Zou
Objective
This study aimed to explore the mediating roles of mindfulness and illness perception in the effects of a social media-based Mindfulness psyCho-behAvioRal intErvention (MCARE) on depressive and anxiety symptoms among patients with ACS.
Methods
This study conducted a secondary longitudinal mediation analysis using data from a randomized controlled trial of the MCARE grogram in patients with ACS. Participants were recruited at two tertiary hospitals in Jinan, China. The MCARE program consisted of six weekly sessions addressing mindfulness training and disease management to facilitate understanding and management of emotions and illness. The analytical sample included participants who completed measures of the primary outcomes, i.e., depression (PHQ-9) and anxiety (GAD-7) and potential mediators, i.e., mindfulness (CAMS-R) and illness perception (Brief-IPQ) at baseline (T0), immediate post-intervention (T1), and 12-week after the commencement of the intervention (T2).
Results
This study included 146 participants (mean age 58.9 years (SD = 8.9), 69.2 % male), including both intervention and control groups. The mediation analysis revealed a significant mediating effect of T1 mindfulness in the relationship between the group and T2 depression symptoms (indirect effect: -0.109, 95 % CI: −0.191, −0.041; P = 0.004), accounting for 26 % of the effect. For T2 anxiety symptoms, T1 illness perception exhibited a significant mediating effect (indirect effect: -0.055, 95 % CI: −0.110, −0.005; P = 0.035), accounting for 22 % of the effect.
Conclusions
This study found that mindfulness and illness perception played a mediating role in the effects of the MCARE program on depressive and anxiety symptoms among patients with ACS.
{"title":"Mechanisms of a mindfulness psyCho-behAvioRal intErvention (MCARE) on depression and anxiety symptoms in patients with acute coronary syndrome: A longitudinal mediation analysis","authors":"Jiatong Cui , Guiqin Zhang , Yunyan Xianyu , Xiaohong Zhang , Yu Xin Cheng , Yu Jia Liu , Wei Xiong , Wei Liu , Qian Liu , Bing Xiang Yang , Huijing Zou","doi":"10.1016/j.jpsychores.2024.111913","DOIUrl":"10.1016/j.jpsychores.2024.111913","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to explore the mediating roles of mindfulness and illness perception in the effects of a social media-based Mindfulness psyCho-behAvioRal intErvention (MCARE) on depressive and anxiety symptoms among patients with ACS.</p></div><div><h3>Methods</h3><p>This study conducted a secondary longitudinal mediation analysis using data from a randomized controlled trial of the MCARE grogram in patients with ACS. Participants were recruited at two tertiary hospitals in Jinan, China. The MCARE program consisted of six weekly sessions addressing mindfulness training and disease management to facilitate understanding and management of emotions and illness. The analytical sample included participants who completed measures of the primary outcomes, i.e., depression (PHQ-9) and anxiety (GAD-7) and potential mediators, i.e., mindfulness (CAMS-R) and illness perception (Brief-IPQ) at baseline (T0), immediate post-intervention (T1), and 12-week after the commencement of the intervention (T2).</p></div><div><h3>Results</h3><p>This study included 146 participants (mean age 58.9 years (<em>SD</em> = 8.9), 69.2 % male), including both intervention and control groups. The mediation analysis revealed a significant mediating effect of T1 mindfulness in the relationship between the group and T2 depression symptoms (indirect effect: -0.109, 95 % <em>CI</em>: −0.191, −0.041; <em>P</em> = 0.004), accounting for 26 % of the effect. For T2 anxiety symptoms, T1 illness perception exhibited a significant mediating effect (indirect effect: -0.055, 95 % <em>CI</em>: −0.110, −0.005; <em>P</em> = 0.035), accounting for 22 % of the effect.</p></div><div><h3>Conclusions</h3><p>This study found that mindfulness and illness perception played a mediating role in the effects of the MCARE program on depressive and anxiety symptoms among patients with ACS.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111913"},"PeriodicalIF":3.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Posttraumatic stress disorder (PTSD) has shown to be related to worse functional outcome in individuals with stroke. This systematic literature review aimed to 1) provide a comprehensive overview of the evidence of prevalence of PTSD after stroke; 2) explore possible differences in prevalence between pathogenic origin of stroke and location of lesion; and 3) explore possible differences in prevalence between method of assessment of PTSD.
Methods
A systematic literature search was performed on studies reporting on PTSD post-stroke. Risk of bias was assessed using an adapted version of the Joanna Briggs Institute's critical appraisal tool.
Results
Thirty studies, reporting on 4320 individuals, were included. The weighted median PTSD prevalence overall was 17.5 % (2.9 %–71.4 %), in ischemic stroke 13.8 %, in transient ischemic attack 4.6 %, in intracerebral hemorrhage 6.5 %, and in subarachnoid hemorrhage 37.1 %. The weighted median prevalence based on self-report questionnaires was 17.8 % (3.7 %–71.4 %,) and based on PTSD interviews 4.0 % (2.9 %–32.8 %). At three and ≥ 12 months post-stroke the weighted median prevalence was respectively 24.7 % (0.0 %–37.1 %) and 17.8 % (6.5 %–71.4 %).
Conclusion
Results suggest that PTSD is common after stroke, and even more so after subarachnoid hemorrhage. This underlines the importance of awareness of and screening for PTSD post-stroke, even after the first year post-stroke.
{"title":"Prevalence of posttraumatic stress disorder after stroke: A systematic literature review","authors":"E.P.J. Janssen , P.J.J. Spauwen , B.A.A. Bus , S.J.M. Rijnen , R.W.H.M. Ponds","doi":"10.1016/j.jpsychores.2024.111914","DOIUrl":"10.1016/j.jpsychores.2024.111914","url":null,"abstract":"<div><h3>Background</h3><p>Posttraumatic stress disorder (PTSD) has shown to be related to worse functional outcome in individuals with stroke. This systematic literature review aimed to 1) provide a comprehensive overview of the evidence of prevalence of PTSD after stroke; 2) explore possible differences in prevalence between pathogenic origin of stroke and location of lesion; and 3) explore possible differences in prevalence between method of assessment of PTSD.</p></div><div><h3>Methods</h3><p>A systematic literature search was performed on studies reporting on PTSD post-stroke. Risk of bias was assessed using an adapted version of the Joanna Briggs Institute's critical appraisal tool.</p></div><div><h3>Results</h3><p>Thirty studies, reporting on 4320 individuals, were included. The weighted median PTSD prevalence overall was 17.5 % (2.9 %–71.4 %), in ischemic stroke 13.8 %, in transient ischemic attack 4.6 %, in intracerebral hemorrhage 6.5 %, and in subarachnoid hemorrhage 37.1 %. The weighted median prevalence based on self-report questionnaires was 17.8 % (3.7 %–71.4 %,) and based on PTSD interviews 4.0 % (2.9 %–32.8 %). At three and ≥ 12 months post-stroke the weighted median prevalence was respectively 24.7 % (0.0 %–37.1 %) and 17.8 % (6.5 %–71.4 %).</p></div><div><h3>Conclusion</h3><p>Results suggest that PTSD is common after stroke, and even more so after subarachnoid hemorrhage. This underlines the importance of awareness of and screening for PTSD post-stroke, even after the first year post-stroke.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111914"},"PeriodicalIF":3.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S002239992400326X/pdfft?md5=35cf49a80780ea2db894644fcf48e68f&pid=1-s2.0-S002239992400326X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although psychological distress is a prevalent issue among patients with amyotrophic lateral sclerosis (ALS) and can impact survival, the risk factors contributing to this distress remain insufficiently understood.
Methods
Patients with ALS who completed the Profile of Mood States (POMS) between June 2017 and March 2022 were included. Participants with moderate to severe cognitive decline were excluded, resulting in the recruitment of 121 patients. The associations between POMS profiles and clinical characteristics were analyzed. Physical motor symptoms were evaluated using the Revised ALS Functional Rating Scale (ALSFRS-R) for objective measurement and the 40-item ALS Assessment Questionnaire (ALSAQ-40) for subjective assessment.
Results
Our model, employing the ALSFRS-R, revealed significant factors associated with overall psychological distress, as assessed by the POMS, including upper limb symptoms, the presence of sleep apnea syndrome, older age at onset, and male sex, with an inverse association with tracheostomy. The POMS subscale scores revealed that anger and depression were significantly associated with upper limb symptoms. The second model, which employed subjective scales, yielded similar results, reinforcing the robustness of our findings. Moreover, subjective bulbar symptoms on the ALSAQ-40 were significantly associated with psychological distress, particularly in female patients.
Conclusion
This study identified the main clinical characteristics significantly associated with psychological distress in patients with ALS. Our findings may be useful in developing individualized psychological management strategies for these patients.
{"title":"Factors associated with psychological distress in patients with amyotrophic lateral sclerosis: A retrospective medical records study","authors":"Mami Nishiyama , Akihiro Koreki , Sagiri Isose , Takahiro Takeda , Ai Ishikawa , Sayuri Kokubun , Yumiko Saito , Kimiko Ito , Kimihito Arai , Nao Takahashi , Yuka Motoda , Satoshi Kuwabara , Kazuhiro Honda","doi":"10.1016/j.jpsychores.2024.111915","DOIUrl":"10.1016/j.jpsychores.2024.111915","url":null,"abstract":"<div><h3>Objective</h3><p>Although psychological distress is a prevalent issue among patients with amyotrophic lateral sclerosis (ALS) and can impact survival, the risk factors contributing to this distress remain insufficiently understood.</p></div><div><h3>Methods</h3><p>Patients with ALS who completed the Profile of Mood States (POMS) between June 2017 and March 2022 were included. Participants with moderate to severe cognitive decline were excluded, resulting in the recruitment of 121 patients. The associations between POMS profiles and clinical characteristics were analyzed. Physical motor symptoms were evaluated using the Revised ALS Functional Rating Scale (ALSFRS-R) for objective measurement and the 40-item ALS Assessment Questionnaire (ALSAQ-40) for subjective assessment.</p></div><div><h3>Results</h3><p>Our model, employing the ALSFRS-R, revealed significant factors associated with overall psychological distress, as assessed by the POMS, including upper limb symptoms, the presence of sleep apnea syndrome, older age at onset, and male sex, with an inverse association with tracheostomy. The POMS subscale scores revealed that anger and depression were significantly associated with upper limb symptoms. The second model, which employed subjective scales, yielded similar results, reinforcing the robustness of our findings. Moreover, subjective bulbar symptoms on the ALSAQ-40 were significantly associated with psychological distress, particularly in female patients.</p></div><div><h3>Conclusion</h3><p>This study identified the main clinical characteristics significantly associated with psychological distress in patients with ALS. Our findings may be useful in developing individualized psychological management strategies for these patients.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111915"},"PeriodicalIF":3.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1016/j.jpsychores.2024.111910
Mei Ieng Lam , Wei Bai , Yuan Feng , Qinge Zhang , Yanbo Zhang , Todd Jackson , Shu-Ying Rao , Tin-Ian Ho , Zhaohui Su , Teris Cheung , Edmundo Patricio Lopes Lao , Sha Sha , Yu-Tao Xiang
Background
Older adults with heart disease often experience higher rates of comorbid anxiety and depression. This study examined depression and anxiety network structures among older adults with heart disease and their heart disease free peers.
Methods
Network analyses of secondary cross-sectional data from the 2017 to 2018 wave of CLHLS were used to construct groups of older adults with and without heart disease using propensity score matching. Depression and anxiety symptoms were assessed using Center for Epidemiological Studies Depression Scale and Generalized Anxiety Disorder Scale, respectively. Central symptoms and bridge symptoms were identified using expected influence.
Results
1689 older adults with heart disease and matched control sample of 1689 older adults without heart disease were included. The prevalence and severity of depression and anxiety were significantly higher in older adults with heart disease compared to the control group. There was no significant difference in overall structures of depression and anxiety network models between two the groups. Key central symptoms and bridge symptoms within these groups were highly similar; GAD 2 “Uncontrollable worrying” and GAD 4 “Trouble relaxing” were identified as the most central symptoms, while GAD 1 “Nervousness” and CESD 1 “Feeling bothered” were identified as key bridge symptoms across both network models.
Conclusion
Depression and anxiety are more prevalent in older adults with heart disease than demographically-matched heart disease free controls. However, network structures of these symptoms do not differ between two groups. Accordingly, depression and anxiety psychosocial interventions developed for older adults without heart disease may also benefit older adults with heart disease.
{"title":"Comparing network structures of depressive and anxiety symptoms between demographically-matched heart disease and heart disease free samples using propensity score matching: Findings from the Chinese Longitudinal Healthy Longevity Survey (CLHLS)","authors":"Mei Ieng Lam , Wei Bai , Yuan Feng , Qinge Zhang , Yanbo Zhang , Todd Jackson , Shu-Ying Rao , Tin-Ian Ho , Zhaohui Su , Teris Cheung , Edmundo Patricio Lopes Lao , Sha Sha , Yu-Tao Xiang","doi":"10.1016/j.jpsychores.2024.111910","DOIUrl":"10.1016/j.jpsychores.2024.111910","url":null,"abstract":"<div><h3>Background</h3><p>Older adults with heart disease often experience higher rates of comorbid anxiety and depression. This study examined depression and anxiety network structures among older adults with heart disease and their heart disease free peers.</p></div><div><h3>Methods</h3><p>Network analyses of secondary cross-sectional data from the 2017 to 2018 wave of CLHLS were used to construct groups of older adults with and without heart disease using propensity score matching. Depression and anxiety symptoms were assessed using Center for Epidemiological Studies Depression Scale and Generalized Anxiety Disorder Scale, respectively. Central symptoms and bridge symptoms were identified using expected influence.</p></div><div><h3>Results</h3><p>1689 older adults with heart disease and matched control sample of 1689 older adults without heart disease were included. The prevalence and severity of depression and anxiety were significantly higher in older adults with heart disease compared to the control group. There was no significant difference in overall structures of depression and anxiety network models between two the groups. Key central symptoms and bridge symptoms within these groups were highly similar; GAD 2 “Uncontrollable worrying” and GAD 4 “Trouble relaxing” were identified as the most central symptoms, while GAD 1 “Nervousness” and CESD 1 “Feeling bothered” were identified as key bridge symptoms across both network models.</p></div><div><h3>Conclusion</h3><p>Depression and anxiety are more prevalent in older adults with heart disease than demographically-matched heart disease free controls. However, network structures of these symptoms do not differ between two groups. Accordingly, depression and anxiety psychosocial interventions developed for older adults without heart disease may also benefit older adults with heart disease.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111910"},"PeriodicalIF":3.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.jpsychores.2024.111911
Aleksandra Tomić , Milica Ječmenica Lukić , Igor Petrović , Vladimir Korkut , Nikola Kresojević , Vladana Marković , Nataša Dragašević Mišković , Marina Svetel , Vladimir S. Kostić
Introduction
Motor imagery (MI) involves recreating a movement mentally without physically performing the movement itself. MI has a positive impact on motor performance, motor learning and neural plasticity. We analysed the connection between motor imagination and altered movement execution in individuals with dystonia, a complex sensorimotor disorder. The aim of our study was to examine MI ability in patients with functional dystonia (FD) in comparison to organic dystonia (OD).
Methods
Our case-control study involved 46 patients, 22 with FD and 24 with OD. The assessment consisted of specific questionnaire and standardized motor, cognitive and psychiatric scales. The KVIQ-20 was used to test MI in each patient.
Results
Patients with FD scored lower on both global visual and kinaesthetic scales of the KVIQ-20 exam compared to patients with OD (63.1 ± 18.5 vs. 73.7 ± 13.2, and 54.9 ± 21.9 vs. 68.8 ± 18.2, respectively). Patients with FD also exhibited visual and/or kinaesthetic MI impairment in different body segments. The internal perspective when imagining movements was preferred in both patients with FD and OD.
Conclusion
FD patients showed global dysfunction of visual and kinaesthetic MI abilities. Techniques for MI improvements might have a potential role in dystonia rehabilitation.
导言 运动想象（MI）是指在不实际做动作的情况下，在头脑中再现动作。运动想象对运动表现、运动学习和神经可塑性有积极影响。我们分析了肌张力障碍（一种复杂的感觉运动障碍）患者的运动想象与运动执行改变之间的联系。我们的研究旨在对功能性肌张力障碍（FD）患者的运动想象能力与器质性肌张力障碍（OD）患者的运动想象能力进行比较。评估包括特定问卷以及标准化的运动、认知和精神量表。结果与OD患者相比，FD患者在KVIQ-20检查的整体视觉和运动感觉量表上的得分都较低（分别为63.1 ± 18.5 vs. 73.7 ± 13.2和54.9 ± 21.9 vs. 68.8 ± 18.2）。FD患者在不同的身体部位也表现出视觉和/或运动神经元损伤。FD和OD患者在想象动作时都更倾向于内部视角。改善肌张力障碍的技术可能在肌张力障碍康复中发挥潜在作用。
{"title":"Motor imagery ability in patients with functional dystonia","authors":"Aleksandra Tomić , Milica Ječmenica Lukić , Igor Petrović , Vladimir Korkut , Nikola Kresojević , Vladana Marković , Nataša Dragašević Mišković , Marina Svetel , Vladimir S. Kostić","doi":"10.1016/j.jpsychores.2024.111911","DOIUrl":"10.1016/j.jpsychores.2024.111911","url":null,"abstract":"<div><h3>Introduction</h3><p>Motor imagery (MI) involves recreating a movement mentally without physically performing the movement itself. MI has a positive impact on motor performance, motor learning and neural plasticity. We analysed the connection between motor imagination and altered movement execution in individuals with dystonia, a complex sensorimotor disorder. The aim of our study was to examine MI ability in patients with functional dystonia (FD) in comparison to organic dystonia (OD).</p></div><div><h3>Methods</h3><p>Our case-control study involved 46 patients, 22 with FD and 24 with OD. The assessment consisted of specific questionnaire and standardized motor, cognitive and psychiatric scales. The KVIQ-20 was used to test MI in each patient.</p></div><div><h3>Results</h3><p>Patients with FD scored lower on both global visual and kinaesthetic scales of the KVIQ-20 exam compared to patients with OD (63.1 ± 18.5 vs. 73.7 ± 13.2, and 54.9 ± 21.9 vs. 68.8 ± 18.2, respectively). Patients with FD also exhibited visual and/or kinaesthetic MI impairment in different body segments. The internal perspective when imagining movements was preferred in both patients with FD and OD.</p></div><div><h3>Conclusion</h3><p>FD patients showed global dysfunction of visual and kinaesthetic MI abilities. Techniques for MI improvements might have a potential role in dystonia rehabilitation.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111911"},"PeriodicalIF":3.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.jpsychores.2024.111912
Yannick Stephan , Angelina R. Sutin , Martina Luchetti , Damaris Aschwanden , Antonio Terracciano
Objectives
Personality traits (i.e., the enduring patterns of thoughts, feelings, and behaviors) are associated with cognition across adulthood. There is interest in identifying potential mechanisms to explain this association, but none has focused on sensory function. Therefore, the present study examined whether an objective measure of hearing acuity mediates the association between personality and memory.
Methods
Participants were from the Health and Retirement Study (HRS, N = 5497, 60 % women, Mean age = 65.66, SD = 9.00) and the English Longitudinal Study of Ageing (ELSA, N = 4706, 57 % women, Mean age = 64.47, SD = 7.59). In the HRS, participants had data on personality and demographic variables in 2012/2014, hearing acuity in 2016/2018, and memory in 2020. In ELSA, participants had data on personality and demographic variables measured in 2010/2011, hearing acuity in 2014/2015, and memory in 2018/2019.
Results
In both HRS and ELSA, higher hearing acuity partially mediated the association between lower neuroticism (4 % and 5 % proportion effect mediated), higher conscientiousness (6 % and 15 %) and higher openness (3 % and 7 %) and better memory performances at follow-up.
Conclusions
The present study provides novel evidence that hearing acuity mediates the association between personality and cognition.
{"title":"The mediational role of hearing acuity in the association between personality and memory: Evidence from the health and retirement study and the English Longitudinal Study of Ageing","authors":"Yannick Stephan , Angelina R. Sutin , Martina Luchetti , Damaris Aschwanden , Antonio Terracciano","doi":"10.1016/j.jpsychores.2024.111912","DOIUrl":"10.1016/j.jpsychores.2024.111912","url":null,"abstract":"<div><h3>Objectives</h3><p>Personality traits (i.e., the enduring patterns of thoughts, feelings, and behaviors) are associated with cognition across adulthood. There is interest in identifying potential mechanisms to explain this association, but none has focused on sensory function. Therefore, the present study examined whether an objective measure of hearing acuity mediates the association between personality and memory.</p></div><div><h3>Methods</h3><p>Participants were from the Health and Retirement Study (HRS, <em>N</em> = 5497, 60 % women, Mean age = 65.66, SD = 9.00) and the English Longitudinal Study of Ageing (ELSA, <em>N</em> = 4706, 57 % women, Mean age = 64.47, SD = 7.59). In the HRS, participants had data on personality and demographic variables in 2012/2014, hearing acuity in 2016/2018, and memory in 2020. In ELSA, participants had data on personality and demographic variables measured in 2010/2011, hearing acuity in 2014/2015, and memory in 2018/2019.</p></div><div><h3>Results</h3><p>In both HRS and ELSA, higher hearing acuity partially mediated the association between lower neuroticism (4 % and 5 % proportion effect mediated), higher conscientiousness (6 % and 15 %) and higher openness (3 % and 7 %) and better memory performances at follow-up.</p></div><div><h3>Conclusions</h3><p>The present study provides novel evidence that hearing acuity mediates the association between personality and cognition.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111912"},"PeriodicalIF":3.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-30DOI: 10.1016/j.jpsychores.2024.111909
Samantha Weber , Lucía Trinidad Rey Álvarez , Juan Ansede-Bermejo , Raquel Cruz , Álvaro del Real , Janine Bühler , Ángel Carracedo , Selma Aybek
Objective
We studied gene-environment, as well as gene-gene interaction to elucidate their effects on symptom severity and predict clinical outcomes in functional neurological disorders (FND).
Methods
Eighty-five patients with mixed FND were genotyped for ten single-nucleotide polymorphisms (SNP) from seven different stress-related genes. We tested cross-sectionally the association between genotype and the symptomatology of FND (symptom severity assessed with the examiner-based clinical global impression score [CGI] and age of onset). Clinical outcome was assessed in 52 patients who participated in a follow-up clinical visit after eight months (following their individual therapies as usual). We tested longitudinally the association between genotype and clinical outcome in FND. We examined the contribution of each SNP and their interaction between them to FND symptomatology and outcome.
Results
We identified a nominal association between tryptophan hydroxylase 1 (TPH1) rs1800532 and symptom severity (CGI1) in FND under a codominant model (T/T: ßT/T = 2.31, seT/T = 0.57; G/T: ßG/T = -0.18, seG/T = 0.29, P = 0.035), with minor allele (T) carriers presenting more severe symptoms. An association was identified between TPH1 and clinical outcome, suggesting that major allele (G) carriers were more likely to have an improved outcome under a codominant model (G/T: ORG/T = 0.18, CIG/T = [0.02–1.34]; T/T: ORT/T = 2.08, CIT/T = [0.30–14.53], P = 0.041). Our analyses suggested a significant gene-gene interaction for TPH2 (rs4570625) and OXTR (rs2254298) on symptom severity, and a significant gene-gene interaction for TPH1, TPH2 and BDNF (rs1491850) on clinical outcome.
Conclusion
FND might arise from a complex interplay between individual predisposing risk genes involved in the serotonergic pathway and their gene-gene interactions.
{"title":"The impact of genetic variations in the serotonergic system on symptom severity and clinical outcome in functional neurological disorders","authors":"Samantha Weber , Lucía Trinidad Rey Álvarez , Juan Ansede-Bermejo , Raquel Cruz , Álvaro del Real , Janine Bühler , Ángel Carracedo , Selma Aybek","doi":"10.1016/j.jpsychores.2024.111909","DOIUrl":"10.1016/j.jpsychores.2024.111909","url":null,"abstract":"<div><h3>Objective</h3><p>We studied gene-environment, as well as gene-gene interaction to elucidate their effects on symptom severity and predict clinical outcomes in functional neurological disorders (FND).</p></div><div><h3>Methods</h3><p>Eighty-five patients with mixed FND were genotyped for ten single-nucleotide polymorphisms (SNP) from seven different stress-related genes. We tested cross-sectionally the association between genotype and the symptomatology of FND (symptom severity assessed with the examiner-based clinical global impression score [CGI] and age of onset). Clinical outcome was assessed in 52 patients who participated in a follow-up clinical visit after eight months (following their individual therapies as usual). We tested longitudinally the association between genotype and clinical outcome in FND. We examined the contribution of each SNP and their interaction between them to FND symptomatology and outcome.</p></div><div><h3>Results</h3><p>We identified a nominal association between tryptophan hydroxylase 1 (<em>TPH1</em>) rs1800532 and symptom severity (CGI<sub>1</sub>) in FND under a codominant model (T/T: ß<sub>T/T</sub> = 2.31, se<sub>T/T</sub> = 0.57; G/T: ß<sub>G/T</sub> = -0.18, se<sub>G/T</sub> = 0.29, <em>P</em> = 0.035), with minor allele (T) carriers presenting more severe symptoms. An association was identified between <em>TPH1</em> and clinical outcome, suggesting that major allele (G) carriers were more likely to have an improved outcome under a codominant model (G/T: OR<sub>G/T</sub> = 0.18, CI<sub>G/T</sub> = [0.02–1.34]; T/T: OR<sub>T/T</sub> = 2.08, CI<sub>T/T</sub> = [0.30–14.53], <em>P</em> = 0.041). Our analyses suggested a significant gene-gene interaction for <em>TPH2</em> (rs4570625) and <em>OXTR</em> (rs2254298) on symptom severity, and a significant gene-gene interaction for <em>TPH1</em>, <em>TPH2</em> and <em>BDNF</em> (rs1491850) on clinical outcome.</p></div><div><h3>Conclusion</h3><p>FND might arise from a complex interplay between individual predisposing risk genes involved in the serotonergic pathway and their gene-gene interactions.</p></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"186 ","pages":"Article 111909"},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022399924003210/pdfft?md5=528576b886c00297cd9eca63c63c7a61&pid=1-s2.0-S0022399924003210-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving stroke rehabilitation: The role of physical activity and mental health support","authors":"Riza Amalia , Ronal Surya Aditya , Alwita Susanti , Rizky Andana Pohan","doi":"10.1016/j.jpsychores.2024.111907","DOIUrl":"10.1016/j.jpsychores.2024.111907","url":null,"abstract":"","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"186 ","pages":"Article 111907"},"PeriodicalIF":3.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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