Journal of Pediatric Health Care最新文献

Introduction: We aimed to evaluate the efficacy, safety, and immunogenicity profile of Etanercept (ETA) and Adalimumab (ADA) biosimilars (BIOs) compared to their originators in children with juvenile idiopathic arthritis (JIA).

Method: Eighty-one JIA children treated with ETA or ADA originators or BIOs were examined at baseline (T0) and after 3- (T1), 6- (T2), 12- (T3), and 24-(T4) months after starting treatment.

Results: Lower Juvenile Arthritis Disease Activity Score 10 (JADAS-10) scores were reported at T1, T2, T3, and T4 in JIA children treated with BIOs than originators (all p < 0.05). At T1 and T3, anti-drugs antibodies levels were lower in children receiving BIOs than originators (p = 0.04 and p = 0.0007, respectively), even after adjustments (both p < 0.05). Relapses were lower for BIOs compared to originators (p < 0.001). Safety profile was comparable between the groups (p > 0.05).

Discussion: A better overall profile of BIOs than originators was demonstrated in JIA children, but larger confirmatory studies are needed.

Navigating health care as a transgender adolescent presents a multitude of unique challenges that warrant careful consideration. Transgender individuals often encounter barriers such as a lack of knowledgeable health care providers, limited access to gender-affirming care, and concerns about confidentiality, safety, and acceptance. This case report of a transgender male with a history of a urinary tract infection examines the issues facing transgender adolescents in their pursuit of appropriate and sensitive health care and the need for normalizing gender-affirming medical care.

Assessment for autism spectrum disorder (ASD) in the pediatric female population entails unique diagnostic complexities. Females are often misdiagnosed, undiagnosed, or receive an ASD diagnosis at a later age than males. Male bias in ASD, masking behaviors, cultural norms, and overlapping neurodevelopmental comorbidities (such as attention deficit/hyperactivity disorder and intellectual disability) contribute to this phenomenon. The authors present two clinical cases evaluated in an interdisciplinary developmental behavioral pediatrics (DBP) team to highlight these considerations. Cases describe adolescent and school aged females with medical complexity who did not initially appear to have ASD symptoms but later were diagnosed with ASD. Patient anonymity is preserved. Best practice recommendations are discussed. Shared decision making, intentional history taking, thorough observation of behavior and restrictive/repetitive/sensory interests in multiple settings, and attention to social communication in the context of cognitive capacity are essential for ASD assessment in pediatric females.

Scald burns occur when the skin encounters hot liquid or steam. Although most scald burns are accidental, the medical provider must assess for possible abuse. We report a case of a 2-year-old female who presented to the hospital with her parents due to a burn to the buttocks with a history of stool expelling from the anus and becoming trapped against the skin. Medical providers need to consider accidental and inflicted differentials, as accidental injuries do occur in children, and an incorrect diagnosis may have severe medicolegal consequences.

This case report describes a full-term infant with a cleft palate who experienced malnutrition because of the delayed introduction of a cleft-adapted bottle and identifies potential areas for improvement in clinical practice. The infant's weight for age z-score at birth was 0.05 and dropped to -1.45 by 2 months of age, indicating mild malnutrition. The infant established care with a cleft team and a cleft-adapted bottle was recommended as the primary feeding method. Feeding time subsequently decreased from 60 minutes per feeding to 20 minutes. The infant presented for palate repair at 9 months of age, and his z-score was -0.01, indicating he was no longer malnourished. Cleft-adapted bottles aid in feeding efficiency in infants with cleft palate, which may subsequently impact weight gain. Appropriate weight gain is essential to receive timely cleft palate repair and support healing.

Research within social media is becoming more prevalent in the current climate of the digital era. However, there is little known about the use of Facebook support groups to recruit hard-to-reach populations like parents of children and youth with special health care needs. This paper reports on a recruitment strategy targeted at Facebook support groups and offers practical guidance for future research based on lessons learned. Recruitment through social media provides increased flexibility and accessibility at little to no cost, but careful consideration should be given to unique ethical requirements and challenges that may arise.

Introduction: Parenting interventions have the potential to become effective strategies for improving the developmental trajectories of infants and children born prematurely. However, the effectiveness of parenting interventions is not well understood.

Methods: A literature search was conducted in five databases. A total of 24 studies involving 3,636 participants were included for review.

Results: The results showed a significant effect in cognition, language, motor development, and behavioral problems of children born prematurely. Parenting stress, anxiety, and interactive behaviors showed significant effect size.

Discussion: This review focuses on interventions that employ scaffolding parenting strategies to enhance the development of children born prematurely. Efforts should continue to empower parents through effective and sustainable parenting interventions to improve the quality of life of preterm children.

Introduction: This study aimed to review approaches to health-related social needs (HRSN) screening and referral in pediatric primary care.

Method: PsycINFO, PubMed, and Google Scholar databases were searched to include peer-reviewed studies conducted in the U.S. over the last 30 years that reported HRSN screening and/or referral outcomes in primary care up to age 18. Studies included multiple HRSN domains and a variety of study designs. Data were summarized descriptively.

Results: 20 studies met inclusion criteria. A variety of screening targets and modalities were employed in addition to referral support methods. Positive screens among the domains reported varied depending on the screening process and sample.

Discussion: This review highlights a range of patient-centered innovations for HRSN screening and referral that may be adaptable to a range of local needs and capacities. Ongoing rigorous evaluation of these models is needed.

Introduction: Parents who use donated gametes or embryos to form their families struggle with telling their children about their genetic origins. We developed the Tool to Empower Parental Telling and Talking (TELL Tool) to support parents in disclosure to their children and an eBook attention control.

Method: A randomized parallel, two-group, attention-controlled clinical pilot trial was conducted online during COVID-19. Feasibility, acceptability, and preliminary effects among parents with children aged 1-16 years were examined.

Results: Over 10 months, our target of 75 parents were enrolled (85% of eligible [95% confidence interval (CI), 76% to 91%]), and 68% (95% CI: 57% to 78%) were retained at 12 weeks. At 4 and 12 weeks, positive trends were found for parental disclosure, telling confidence, and anxiety compared with attention controls.

Discussion: The study protocol is feasible, and the TELL Tool is acceptable to parents and demonstrates a positive effect on parents' ability to tell their children. The results support the implementation of a large efficacy trial.