Journal of Neuroradiology最新文献

{"title":"Concomitant progressive supranuclear palsy and multiple system atrophy: A rare case report of tauopathy and synucleinopathy interface","authors":"Nitesh Shekhrajka,&nbsp;Márcio Luís Duarte,&nbsp;Leonardo Furtado Freitas","doi":"10.1016/j.neurad.2025.101347","DOIUrl":"10.1016/j.neurad.2025.101347","url":null,"abstract":"<div><div>Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are neurodegenerative disorders characterized by parkinsonian symptoms. PSP typically presents with supranuclear gaze palsy, postural instability, and subcortical dementia, while dysautonomia and cerebellar signs are hallmark features of MSA. We report the case of a 77-year-old male patient with a four-year history of progressive parkinsonian symptoms that have shown poor response to treatment. His clinical manifestations included bradykinesia, rigidity, swallowing difficulties, urinary frequency, nocturia, downward gaze palsy, hypometric saccades, and finger-nose dysmetria. Examination revealed increased tone in both upper extremities, more pronounced on the right side, along with bradykinesia, slow hand movements, and bilateral decrement in finger tapping. Brain magnetic resonance imaging (MRI) revealed mixed MRI findings consistent with atypical parkinsonian syndrome, showing signs of MSA-C with pontocerebellar atrophy and the \"hot cross bun\" sign, as well as PSP with midbrain atrophy (hummingbird sign) and tegmental hypersignal.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101347"},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of HR 3D-CBCT and squid 12® embolic agent in meningioma management: Insights from MRI modifications at follow-Up","authors":"Guglielmo Pero ,&nbsp;Antonio Macera ,&nbsp;Claudia Rollo ,&nbsp;Amedeo Cervo ,&nbsp;Branko Popadic ,&nbsp;Alessandro La Camera","doi":"10.1016/j.neurad.2025.101346","DOIUrl":"10.1016/j.neurad.2025.101346","url":null,"abstract":"<div><div>We report three cases of meningiomas treated with Squid 12® with their peculiar technical aspects. High-resolution 3D cone-beam CT angiography (HR 3D-CBCT) was used to evaluate the tumor’s vascular anatomy and guide embolization, revealing pial arterial supplies not readily visible on standard angiography. Squid 12® achieved deep tumor penetration, abolishing contrast enhancement on immediate post-procedural MRI. Follow-up MRIs showed progressive tumor shrinkage, with peripheral ring enhancement and decreased edema. Tumor volume was reduced by approximately 50% at the 4-6 months follow-up, leading to a delay in SRS for further stabilization and clinical improvement in the symptomatic patients.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101346"},"PeriodicalIF":3.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of occlusion location in the middle cerebral artery during endovascular reperfusion therapy for acute ischemic stroke with underlying intracranial atherosclerotic stenosis","authors":"Joong-Goo Kim ,&nbsp;Chul-Hoo Kang ,&nbsp;Hong Jun Kim ,&nbsp;Jong Kook Rhim ,&nbsp;Jay Chol Choi ,&nbsp;Doo Hyuk Kwon","doi":"10.1016/j.neurad.2025.101340","DOIUrl":"10.1016/j.neurad.2025.101340","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>This study examines the clinical outcomes of endovascular reperfusion therapy and emergent intracranial stenting based on the angiographically defined occlusion location of the middle cerebral artery (MCA).</div></div><div><h3>Materials and Methods</h3><div>We reviewed consecutive patients with acute MCA infarct associated with intracranial atherosclerotic stenosis (ICAS) who underwent rescue intracranial stenting and balloon angioplasty after initial mechanical thrombectomy. We compared patient demographics, baseline characteristics, clinical outcomes, and periprocedural complications, including in-stent thrombosis and re-occlusion, according to the MCA occlusion location. The occlusion location was categorized based on the presence of the proximal MCA stump in enrolled ICAS patients.</div></div><div><h3>Results</h3><div>Of 47 patients, 30 (63.8 %) were classified as having a stump group. The initial NIHSS was more severe in the without-stump group compared to the with-stump group (13.0 [8.0–16.0] vs. 8.0 [8.0–13.0] <em>p</em> = 0.078). There were no significant differences in procedure time, technique, and devices. However, the successful revascularization rate was significantly lower in the without-stump group (64.7 % vs. 100 %, <em>p</em> = 0.002). Additionally, the immediate re-occlusion rate after the first endovascular reperfusion therapy tended to be higher in the without-stump group (76.5 % vs. 36.7 %, <em>p</em> = 0.02). No significant association was found between periprocedural complications, including intracerebral hemorrhage and mortality.</div></div><div><h3>Conclusions</h3><div>Angiographically presented MCA occlusion without a stump in acute large vessel occlusion underlying ICAS predicts more complicated intracranial stenting and poorer clinical outcomes than patients with a stump.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101340"},"PeriodicalIF":3.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroanatomical features of NAA10 and NAA15-related neurodevelopmental syndromes","authors":"Rahi Patel ,&nbsp;Rikhil Makwana ,&nbsp;Carolina Christ ,&nbsp;Elaine Marchi ,&nbsp;Christina Y. Miyake ,&nbsp;Fabricio Guimaraes Goncalves ,&nbsp;Gholson J. Lyon ,&nbsp;Matthew T. Whitehead","doi":"10.1016/j.neurad.2025.101339","DOIUrl":"10.1016/j.neurad.2025.101339","url":null,"abstract":"<div><h3>Background</h3><div><em>NAA10</em>-related and <em>NAA15</em>-related neurodevelopmental (ND) syndromes present with intellectual disability, hypotonia, cardiac abnormalities, and delayed development. While data exists on the clinical manifestations of these conditions, there are few reports describing the neuroanatomical abnormalities present on imaging.</div></div><div><h3>Objective</h3><div>We aim to provide neuroimaging analyses for a subset of probands with <em>NAA10-</em> and <em>NAA15</em>-related neurodevelopmental symptoms and assess the severity and number of neuroanatomical anomalies and their associated functional impairments to better understand the pathophysiology of these disease processes.</div></div><div><h3>Materials and methods</h3><div>Neuroimaging studies were obtained from 26 probands (18 with pathogenic variants in <em>NAA10</em>, 8 with pathogenic variants in <em>NAA15</em>) and evaluated. In depth medical histories were also collected on probands, including genetic testing results and developmental history. The Vineland 3 Adaptive Behavior Scale was also administered to assess functional status of the probands.</div></div><div><h3>Results</h3><div>On average, individuals with NAA10-related ND syndrome had 5.7 anatomical abnormalities (standard deviation (SD) = 3.0), whereas those with <em>NAA15</em>-related ND syndrome had 2.8 (SD = 2.3, <em>p</em> = 0.02). Probands with a greater number of anatomical abnormalities tended to score worse on Vineland assessments. Structure and function were correlated such that individuals with greater defects on, for example, motor regions of their scans, tested worse on motor portions of the Vineland. Probands followed longitudinally demonstrated several changes between scans, most commonly in the cerebellum, brainstem, and degree of myelination. Such changes were only observed for probands with NAA10-related ND syndrome.</div></div><div><h3>Conclusion</h3><div>This analysis of a cohort of probands with NAA10-related ND syndrome and <em>NAA15</em>-related ND syndrome by two neuroradiologists has established a range of subtle abnormalities. We hope these findings guide future research and diagnostic studies for this population.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101339"},"PeriodicalIF":3.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct puncture and transarterial embolization for preoperative treatment of sinonasal tumors","authors":"Cassidy Werner,&nbsp;Timothy G White,&nbsp;Shyle H Mehta,&nbsp;Kevin A Shah,&nbsp;Judd H Fastenberg,&nbsp;Athos Patsalides","doi":"10.1016/j.neurad.2025.101337","DOIUrl":"10.1016/j.neurad.2025.101337","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101337"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging follow-up of unruptured intracranial aneurysms treated with flow diverter: Insights from a French collaborative survey","authors":"Thomas Marque ,&nbsp;Victor Dumas ,&nbsp;Thibault Agripnidis ,&nbsp;François Zhu ,&nbsp;Guillaume Charbonnier ,&nbsp;Baptiste Donnard ,&nbsp;Quentin Holay ,&nbsp;Jean Darcourt ,&nbsp;Luca Scarcia ,&nbsp;Alexis Guédon ,&nbsp;Vincent L'Allinec ,&nbsp;Jean-Baptiste Girot ,&nbsp;Gaultier Marnat ,&nbsp;Géraud Forestier ,&nbsp;Guillaume Bellanger ,&nbsp;Quentin Alias ,&nbsp;Louis Bonnard ,&nbsp;Romain Bourcier ,&nbsp;Julien Allard ,&nbsp;Martin Bretzner ,&nbsp;Julien Burel","doi":"10.1016/j.neurad.2025.101338","DOIUrl":"10.1016/j.neurad.2025.101338","url":null,"abstract":"<div><h3>Purpose</h3><div>The absence of standardized guidelines for imaging follow-up of unruptured intracranial aneurysms treated with flow diverters (FD) results in significant variability across centers. This survey aims to provide a comprehensive overview of current imaging follow-up practices in French academic centers.</div></div><div><h3>Methods</h3><div>In April 2024, a 49-question survey was distributed to interventional neuroradiology centers in France through the trainee-led research collaborative network, Jeunes En Neuroradiologie Interventionnelle-Research Collaborative (JENI-RC). The survey covered follow-up protocols for digital subtraction angiography (DSA), magnetic resonance imaging (MRI), and computed tomography (CT), as well as potential modifications for specific cases.</div></div><div><h3>Results</h3><div>Twenty interventional neuroradiology centers responded to the survey. Most centers (<em>n</em> = 14, 70 %), conducted a single systematic DSA either at 6 or 12 months post-procedure. In most centers (<em>n</em> = 13, 65 %), a second DSA was scheduled only based on the results of the first, specifically in cases of non-occluded aneurysm, intimal hyperplasia, or in-stent stenosis. MRI follow-up varied, with most centers (<em>n</em> = 12, 60 %) performing three MRIs over five years. Only two centers included CT scans in their protocols.</div></div><div><h3>Conclusion</h3><div>This survey highlights the substantial heterogeneity in imaging follow-up protocols for FD-treated unruptured intracranial aneurysms among French academic centers. The findings underscore the urgent need for standardized guidelines to harmonize practices, optimize patient outcomes, and improve resource utilization. Additionally, innovations in FD technology, advancements in MRI sequences, and the advent of photon-counting CT will likely influence follow-up practices in the near future.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101338"},"PeriodicalIF":3.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occult craniosynostosis in normocephalic children with Chiari I malformation","authors":"Hadleigh Cuthbert,&nbsp;Pasquale Gallo,&nbsp;Luke Galloway,&nbsp;Aimee Goel,&nbsp;Fardad T. Afshari,&nbsp;Guirish A. Solanki,&nbsp;Desiderio Rodrigues,&nbsp;Richard Gagen,&nbsp;Joshua Pepper","doi":"10.1016/j.neurad.2025.101336","DOIUrl":"10.1016/j.neurad.2025.101336","url":null,"abstract":"<div><h3>Background</h3><div>There are numerous theories regarding the development of paediatric Chiari I malformation. We hypothesise a subset may be related to early calvarial suture closure, which may occur too late to cause an abnormal head shape but early enough that changes in intracranial pressure lead to the development of tonsillar descent. Isolated single suture craniosynostosis is not typically associated with Chiari I malformation. We assessed our series of children with Chiari I malformation to establish what proportion harboured an undiagnosed craniosynostosis.</div></div><div><h3>Methods</h3><div>This was a single-centre retrospective review of all children with Chiari I malformation from 2012 to 2022. Imaging was reviewed for the presence of a craniosynostosis. Clinical records of synostotic patients were reviewed to establish whether they had a craniofacial disorder or were under the care of the craniofacial team. If neither applied then they were considered to have an ‘incidental craniosynostosis’.</div></div><div><h3>Results</h3><div>The study included six-hundred-and-nineteen patients with Chiari I malformation, with a mean age at diagnosis of 8.7 years. 13.4 % of patients had radiological evidence of an incidentally-detected craniosynostosis, most commonly the sagittal suture (95.7 %). Incidental craniosynostosis was mostly observed in normocephalic children, but dolichocephaly was associated with an increased risk of concurrent sagittal craniosynostosis.</div></div><div><h3>Conclusions</h3><div>Craniosynostosis in normocephalic children with a Chiari I malformation is an under-diagnosed phenomenon. Given the high rate of correlation we recommend assessing specifically for craniosynostosis in all children with a ‘simple’ Chiari I malformation prior to any intervention.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101336"},"PeriodicalIF":3.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular stenting for intracranial venous hypertension caused by meningioma: A case series and systematic literature review","authors":"Thomas Courret ,&nbsp;Xavier Barreau ,&nbsp;Julien Engelhardt ,&nbsp;Vincent Jecko ,&nbsp;Omer Eker ,&nbsp;Emilie Tournaire-Marques ,&nbsp;Thomas Tourdias ,&nbsp;Gaultier Marnat","doi":"10.1016/j.neurad.2025.101335","DOIUrl":"10.1016/j.neurad.2025.101335","url":null,"abstract":"<div><h3>Background &amp; purpose</h3><div>Venous intracranial hypertension is defined as an increased intracranial pressure secondary to venous congestion. Specific causes of venous hypertension can be identified, including extrinsic venous sinus compression or invasion by intracranial tumors such as meningioma. We aimed to report a case series of four patients with symptomatic venous intracranial hypertension secondary to meningioma and treated with stenting. We also performed a systematic literature review.</div></div><div><h3>Methods</h3><div>The local case series included consecutive patients with symptomatic venous intracranial hypertension who underwent venous sinus stenting in our center between January 2010 and June 2024. Initial clinical presentation, imaging data, treatment details and long-term outcomes were presented. A systematic literature review was performed according to PRISMA guidelines up to June 2024.</div></div><div><h3>Results</h3><div>Four patients were treated in our center during the study period. In all cases, stenting was adequately performed without complication. Patients experienced substantial and durable clinical improvement, including papilledema resorption. Eight publications were included in the literature review (28 patients). Including our 4 reported cases, a total of 32 patients were analyzed in the systematic review. Complete symptoms recovery occurred in 25 patients (78.1 %) and a partial resolution in 7 (21.9 %). Twelve patients received adjuvant radiotherapy, two of whom also underwent surgery. Five patients presented clinical recurrence and required endovascular retreatment. No complications were reported.</div></div><div><h3>Conclusion</h3><div>In the setting of a compression or invasion due to a meningioma, stenting of symptomatic intracranial venous stenoses appeared as a safe and promisingly effective option.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 3","pages":"Article 101335"},"PeriodicalIF":3.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caractéristiques IRM de la neurotoxicité centrale liée à la chimiothérapie : revue illustrée","authors":"Ismail Mohamed Halfi,&nbsp;Firdaous Touarsa,&nbsp;Mohamed Jiddane","doi":"10.1016/j.neurad.2025.101293","DOIUrl":"10.1016/j.neurad.2025.101293","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;L'incidence croissante du cancer et les progrès des traitements ont entraîné une augmentation correspondante de la neurotoxicité liée à la chimiothérapie. Cette neurotoxicité est une complication importante et de plus en plus fréquente chez les patients oncologiques. Les études montrent que 19 % à plus de 85 % des personnes recevant une chimiothérapie présentent divers symptômes neurologiques. Distinguer ces symptômes de la progression tumorale ou des syndromes paranéoplasiques peut être difficile, ce qui rend l'imagerie essentielle pour gérer ces complications. Cette présentation vise à éclairer les motifs d'imagerie IRM associés à la neurotoxicité induite par la chimiothérapie et à fournir des exemples illustratifs basés sur des cas.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Principaux Points Pédagogiques&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Prévalence et défis diagnostiques :&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;La neurotoxicité liée à la chimiothérapie affecte une part importante des patients, présentant des manifestations neurologiques variées. Ces symptômes se chevauchent souvent avec d'autres conditions telles que la progression tumorale et les syndromes paranéoplasiques, compliquant le diagnostic.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Motifs d'imagerie IRM :&lt;/strong&gt;&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Leuco encéphalopathie aiguë-subaiguë :&lt;/strong&gt; Ce motif, souvent associé à l'utilisation de méthotrexate, se caractérise par des changements réversibles sur l'imagerie en pondération de diffusion (DWI). L'IRM révèle des lésions aiguë à subaiguë de la matière blanche qui peuvent régresser après l'arrêt du traitement.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Syndrome cérébelleux aigu :&lt;/strong&gt; La cytarabine à haute dose est connue pour induire ce syndrome, visible sur l'IRM comme une toxicité cérébelleuse aiguë réversible avec des caractéristiques spécifiques à l'imagerie.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Syndrome d'encéphalopathie réversible postérieure (PRES) :&lt;/strong&gt; L'IRM peut montrer un œdème réversible dans les régions postérieures du cerveau, généralement associé à une hypertension sévère ou à des changements rapides de fluides.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Complications neurovasculaires :&lt;/strong&gt; Les motifs incluent des anomalies liées aux perturbations vasculaires, qui peuvent se manifester sous forme de lésions ischémiques ou hémorragiques.&lt;/div&gt;&lt;div&gt;&lt;strong&gt;Leuco encéphalopathie multifocale progressive (PML) :&lt;/strong&gt; Les caractéristiques IRM de la PML incluent des lésions démyélinisantes affectant principalement la matière blanche.&lt;strong&gt;Toxicité de la moelle épinière :&lt;/strong&gt; Les lésions induites par la chimiothérapie de la moelle épinière peuvent se présenter comme une myélopathie localisée ou diffuse à l'IRM.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Cette présentation souligne le rôle crucial de l'IRM dans le diagnostic et la différenciation de la neurotoxicité induite par la chimiothérapie par rapport à d'autres affections neurologiques. En présentant divers motifs d'imagerie IRM et des exemples illustratifs, elle vise à amé","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101293"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEP, NMO, MOGAD : Lever le voile sur la névrite optique","authors":"Hajar Andour ,&nbsp;Hamza Bouayad ,&nbsp;Louaà Seghini ,&nbsp;Mohamed Hassan ,&nbsp;Mohamed Jiddane ,&nbsp;Firdaous Touarsa","doi":"10.1016/j.neurad.2025.101296","DOIUrl":"10.1016/j.neurad.2025.101296","url":null,"abstract":"<div><h3>Objectifs</h3><div>- Souligner les caractéristiques cliniques et pronostiques de la sclérose en plaques (SEP), de la maladie associée aux anticorps anti-glycoprotéines oligodendrocytaires de la myéline (MOGAD) et des troubles du spectre de la neuromyélite optique (NMOSD).</div><div>- Y Identifier les éléments distinctifs de la névrite optique (NO) à l'IRM combinée à la tomographie par cohérence optique (OCT) en introduisant les nouveaux critères diagnostiques de la SEP.</div></div><div><h3>Résumé</h3><div>-La NO est souvent associée à des maladies démyélinisantes, notamment la SEP, les NMOSD et les</div><div>MOGAD, les dernières médiées par des anticorps. La NO peut compliquer le diagnostic par une présentation isolée atypique. La disponibilité limitée des tests d'anticorps, leur variable sensibilité et fluctuation nécessite la différentiation précise de ces affections.</div><div>- Une combinaison d'IRM conventionnelle et non conventionnelle aux résultats d'OCT peut améliorer la précision diagnostique.</div></div><div><h3>Messages à retenir</h3><div>- La névrite optique en SEP est typiquement unilatérale, focale et antérieure, or, généralement bilatérale et longue; antérieure en MOGAD et postérieure en NMOSD.</div><div>- Le rapport de transfert de magnétisation ;est un marqueur de démyélinisation réduit sur l'ensemble du nerf optique qui améliore la spécificité diagnostique notamment entre SEP et NMOSD.</div><div>- L’épaisseur des fibres nerveuses rétiniennes (RNFL) et la couche plexiforme interne de cellules ganglionnaires (CGIPL) à l'OCT sont réduits dans ces pathologies démyélinisantes.</div><div>Un amincissement significatif isolé ou associés aux données IRM, améliore la précision diagnostique de MOGAD.</div><div>- Les données supplémentaires, notamment d'IRM cervicale, sont parfois nécessaires pour distinguer NMOSD et MOGAD en cas de névrite optique isolée non aiguë.</div><div>-De nouveaux critères diagnostiques sont introduits pour le diagnostic de SEP, incluant la névrite optique, les données d'OCT et le biomarqueur des chaines kappa légères d'immunoglobulines.</div></div><div><h3>Conclusion</h3><div>La distinction correcte entre SEP, NMOSD et MOGAD est cruciale pour une prise en charge optimale.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 2","pages":"Article 101296"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}