Journal of Neuroradiology最新文献

英文中文

Abnormalities in spontaneous brain activity and functional connectivity are associated with cognitive impairments in children with type 1 diabetes mellitus 自发脑活动和功能连接异常与 1 型糖尿病儿童的认知障碍有关。

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-05-29 DOI: 10.1016/j.neurad.2024.101209

Jia-Wen Song , Xiao-Yan Huang , Mei Huang , Shi-Han Cui , Yong-Jin Zhou , Xiao-Zheng Liu , Zhi-Han Yan , Xin-Jian Ye , Kun Liu

Background

It remains unclear whether alterations in brain function occur in the early stage of pediatric type 1 diabetes mellitus(T1DM). We aimed to examine changes in spontaneous brain activity and functional connectivity (FC) in children with T1DM using resting-state functional magnetic resonance imaging (rs-fMRI), and to pinpoint potential links between neural changes and cognitive performance.

Methods

In this study, 22 T1DM children and 21 age-, sex-matched healthy controls underwent rs-fMRI. The amplitude of low frequency fluctuations (ALFF) and seed-based FC analysis were performed to examine changes in intrinsic brain activity and functional networks in T1DM children. Partial correlation analyses were utilized to explore the correlations between ALFF values and clinical parameters.

Results

The ALFF values were significantly lower in the lingual gyrus (LG) and higher in the left medial superior frontal gyrus (MSFG) in T1DM children compared to controls. Subsequent FC analysis indicated that the LG had decreased FC with bilateral inferior occipital gyrus, and the left MSFG had decreased FC with right precentral gyrus, right inferior parietal gyrus and right postcentral gyrus in children with T1DM. The ALFF values of LG were positively correlated with full-scale intelligence quotient and age at disease onset in T1DM children, while the ALFF values of left MSFG were positively correlated with working memory scores.

Conclusion

Our findings revealed abnormal spontaneous activity and FC in brain regions related to visual, memory, default mode network, and sensorimotor network in the early stage of T1DM children, which may aid in further understanding the mechanisms underlying T1DM-associated cognitive dysfunction.

背景：目前仍不清楚小儿1型糖尿病（T1DM）早期是否会出现脑功能改变。我们的目的是利用静息态功能磁共振成像（rs-fMRI）检查T1DM患儿大脑自发活动和功能连接（FC）的变化，并找出神经变化与认知表现之间的潜在联系：在这项研究中，22 名 T1DM 儿童和 21 名年龄、性别匹配的健康对照者接受了 rs-fMRI 检查。方法：22 名 T1DM 儿童和 21 名年龄、性别相匹配的健康对照组接受了 rs-fMRI 检查，通过低频波动幅度（ALFF）和基于种子的 FC 分析，研究 T1DM 儿童大脑固有活动和功能网络的变化。利用偏相关分析探讨了ALFF值与临床参数之间的相关性：结果：与对照组相比，T1DM患儿舌回（LG）的ALFF值明显较低，而左侧内侧额上回（MSFG）的ALFF值较高。随后的FC分析表明，T1DM患儿舌回与双侧枕下回的FC降低，左侧额上回与右侧中央前回、右侧顶下回和右侧中央后回的FC降低。LG的ALFF值与T1DM儿童的全面智商和发病年龄呈正相关，而左侧MSFG的ALFF值与工作记忆得分呈正相关：我们的研究结果表明，在T1DM儿童的早期阶段，与视觉、记忆、默认模式网络和感觉运动网络相关的脑区存在异常的自发活动和FC，这可能有助于进一步了解T1DM相关认知功能障碍的机制。

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引用次数: 0

Pediatric cervical spine clearance after blunt trauma and negative CT: What is the role of MRI? 钝性外伤和 CT 阴性后的小儿颈椎清创：核磁共振成像的作用是什么？

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-05-25 DOI: 10.1016/j.neurad.2024.101206

Nazanin Azizi, Jimmy L. Huynh, Osama Raslan, Matthew Bobinski, Lotfi Hacein-Bey, Arzu Ozturk

Background and purpose

The cervical spine in children has marked anatomical and biomechanical differences compared to adults, leading to significantly different patterns and incidence of spinal injury, and consequently to different X-ray and computed tomography (CT) imaging recommendations. Magnetic resonance imaging (MRI) has been validated to clear cervical spine trauma in adults, but not in pediatric patients. We hypothesized that MRI findings have a low probability to change management in children with spine trauma and negative CT findings.

Materials and methods

We reviewed records for admitted pediatric patients due to blunt trauma from January 2011 to May 2021, and identified 212 patients who underwent MRI within 3 days of a negative CT. Two neuroradiologists independently reviewed all CT and MRI images for the following categories: fracture, subluxation, spinal canal compromise, ligamentous injury, spinal canal hemorrhage, cord contusion and soft tissue hemorrhage. We identified follow-up MRI examinations as negative or positive for the above categories, and calculated the prevalence of each category as a percentage of cases with negative CT. We also evaluated whether negative and positive MRI groups differed significantly with respect to age and sex of the patients.

Results and conclusions

In our study of 212 children with cervical spine trauma and a negative CT, most follow-up MRI scans were found to be negative (79.9 %). Positive MRI findings consisted mainly of ligamentous sprain without disruption (15.1 %). Ligamentous disruption and epidural or soft tissue hemorrhage were found in 4.5 %, and focal cord contusion in 0.5 %. There was no statically significant difference between negative and positive MRI groups with respect to age (P = 0.45) and sex (P = 0.52).

Conclusion

In our patient group with a negative CT, MRI did not significantly impact management nor contribute to cervical spine clearance in children.

背景和目的：与成人相比，儿童的颈椎在解剖学和生物力学上有明显的差异，导致脊柱损伤的模式和发生率明显不同，因此也有不同的 X 光和计算机断层扫描（CT）成像建议。磁共振成像（MRI）已被证实可用于明确成人颈椎创伤，但在儿科患者中尚未得到证实。我们假设，对于脊柱外伤且 CT 检查结果呈阴性的儿童患者，磁共振成像结果改变治疗方案的可能性较低：我们查阅了 2011 年 1 月至 2021 年 5 月期间因钝性外伤入院的儿科患者的病历，并确定了 212 名在 CT 阴性后 3 天内接受 MRI 检查的患者。两名神经放射科医生独立审查了所有 CT 和 MRI 图像，以确定以下类别：骨折、脱位、椎管损伤、韧带损伤、椎管出血、脊髓挫伤和软组织出血。我们将后续磁共振成像检查确定为上述类别的阴性或阳性，并以 CT 阴性病例的百分比来计算每个类别的患病率。我们还评估了磁共振成像阴性组和阳性组在患者年龄和性别方面是否存在显著差异：在我们对 212 名颈椎外伤且 CT 阴性的儿童进行的研究中，发现大多数随访核磁共振扫描结果为阴性（79.9%）。核磁共振成像阳性结果主要是韧带扭伤而无中断（15.1%）。韧带断裂和硬膜外或软组织出血占 4.5%，局灶性脊髓挫伤占 0.5%。核磁共振成像阴性组和阳性组在年龄（P = 0.45）和性别（P = 0.52）方面的差异无统计学意义：结论：在我们的 CT 阴性患者群体中，磁共振成像对儿童颈椎病的治疗没有明显影响，也无助于颈椎病的清除。

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引用次数: 0

Let's find out about Article-Based Publishing (ABP)/Article Numbering (AN) 让我们了解一下文章出版 (ABP)/ 文章编号 (AN)

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-05-24 DOI: 10.1016/j.neurad.2024.101198

Douraied Ben Salem

引用次数: 0

Meditation mindfulness and hypnosis: We know they work, but just how do they work? 冥想、正念和催眠：我们知道它们有用，但它们是如何起作用的呢？

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-05-15 DOI: 10.1016/j.neurad.2024.101199

Lotfi Hacein-Bey, Sidney Krystal, Jean-Pierre Pruvo

引用次数: 0

A call for junior neuroradiologists to join the “Jeunes Enthousiastes en neuroradiologie DIagnostique” - Research Collaboration (JEDI-RC) 征集初级神经放射医师加入 "Jeunes Enthousiastes en neuroradiologie DIagnostique"--研究合作组织（JEDI-RC）。

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-04-30 DOI: 10.1016/j.neurad.2024.04.003

Thomas Samoyeau

引用次数: 0

The importance of arterial systolic pressure (Push) in successful first pass aspiration technique for endovascular thrombectomy 动脉收缩压（Push）对成功实施血管内血栓切除术的首次抽吸技术的重要性。

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-04-25 DOI: 10.1016/j.neurad.2024.04.004

D Volders, V Linehan, IR Macdonald

引用次数: 0

Reply to “Successful recanalization because of the pressure differential between arterial systolic pressure (Push) and vacuum level created by the vacuum source (Pull)” 回复 "由于动脉收缩压（推力）与真空源产生的真空度（拉力）之间存在压力差，因此可成功再通脉"。

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-04-25 DOI: 10.1016/j.neurad.2024.04.005

Guillaume Charbonnier, Fortunato Di Caterino, Alessandra Biondi

引用次数: 0

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-04-17 DOI: 10.1016/j.neurad.2024.04.002

Hiroyuki Ikeda, Masanori Kinosada, Minami Uezato, Yoshitaka Kurosaki, Masaki Chin, Sen Yamagata

Background

Thrombectomy with a stent retriever (SR) may lead to intracranial hemorrhage due to vessel displacement. We aimed to explore factors related to vessel displacement using an in vitro vessel model.

Methods

A vessel model mimicking two-dimensional left internal carotid angiography findings was used in this study. Six SR types (Solitaire 3 × 40, 4 × 40, and 6 × 40; Embotrap 5 × 37; Trevo 4 × 41; and Tron 4 × 40) were fully deployed in the M2 ascending, M2 bend, or M1 horizontal portion. Subsequently, the SR was retracted, and the vessel displacement, maximum SR retraction force, and angle of the M2 bend portion were measured. A total of 180 SR retraction experiments were conducted using 6 SR types at 3 deployment positions with 10 repetitions each.

Results

The mean maximum distance of vessel displacement for Embotrap Ⅲ 5 × 37 (6.4 ± 3.5 mm, n = 30) was significantly longer than that for the other five SR types (p = 0.029 for Solitaire 6 × 40 and p < 0.001 for the others, respectively). Vessel displacement was significantly longer in the M2 ascending portion group (5.4 ± 3.0 mm, n = 60) than in the M2 bend portion group (3.3 ± 1.6 mm, n = 60) (p < 0.001) and it was significantly longer in the M2 bend portion group than in the M1 horizontal portion group (1.1 ± 0.7 mm, n = 60) (p < 0.001). A positive correlation existed between the mean maximum SR retraction force or mean angle of the M2 bend portion due to SR retraction (i.e., vessel straightening) and the mean maximum distance of vessel displacement (r = 0.90, p < 0.001; r = 0.90, p < 0.001, respectively).

Conclusions

Vessel displacement varied with the SR type, size, and deployment position. Moreover, vessel displacement correlated with the SR retraction force or vessel straightening of the M2 bend portion.

使用支架回流器（SR）进行血栓清除术可能会因血管移位而导致颅内出血。我们旨在利用体外血管模型探讨与血管移位有关的因素。本研究使用了一个模仿二维左侧颈内动脉造影结果的血管模型。六种类型的 SR（Solitaire 3 × 40、4 × 40 和 6 × 40；Embotrap 5 × 37；Trevo 4 × 41 和 Tron 4 × 40）在 M2 升支、M2 弯支或 M1 水平部分完全展开。随后，SR 回缩，并测量血管位移、最大 SR 回缩力和 M2 弯曲部分的角度。在 3 个部署位置使用 6 种 SR 进行了共计 180 次 SR 回缩实验，每次重复 10 次。Embotrap Ⅲ 5 × 37 的血管位移平均最大距离（6.4 ± 3.5 mm，= 30）明显长于其他五种 SR 类型（Solitaire 6 × 40 = 0.029，其他类型小于 0.001）。M2 上升部分组的血管移位（5.4 ± 3.0 mm，= 60）明显长于 M2 弯曲部分组（3.3 ± 1.6 mm，= 60）（< 0.001），M2 弯曲部分组的血管移位明显长于 M1 水平部分组（1.1 ± 0.7 mm，= 60）（< 0.001）。平均最大 SR 回缩力或因 SR 回缩（即血管拉直）造成的 M2 弯曲部分的平均角度与平均最大血管移位距离之间存在正相关（分别为 = 0.90，< 0.001；= 0.90，< 0.001）。血管位移随 SR 类型、大小和部署位置而变化。此外，血管位移与 SR 回缩力或 M2 弯曲部分的血管伸直度相关。

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引用次数: 0

CT analysis of skull contents in naturally mummified human corpses, a multicentric study 自然木乃伊化人类尸体头骨内容的 CT 分析，一项多中心研究

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-04-07 DOI: 10.1016/j.neurad.2024.04.001

Maëlle Guéganton-Lecat , Romain Provost , Tania Delabarde , Claire Saccardy , Mathilde Ducloyer , Douraied Ben Salem

Introduction

This study aimed to assess skull contents, brain appearance, and density on postmortem computed tomography in naturally mummified corpses.

Material and Methods

For this purpose, a retrospective multicentric study, including mummified corpses from two French centers (Brest and Nantes) and from the New Mexico Decedent Image Database (USA), was performed by analyzing postmortem computed tomography (PMCT) focused on the head and neck of partially or fully mummified corpses discovered between 2011 and 2022. The PMCT analysis provided data on the CT appearance of brains, allowing them to be classified into four different categories (desiccation, liquefaction, dura mater only (DMO), and absence), and to measure densities (HU) of the brain remains. In addition, data on postmortem intervals (PMI) from Nantes and Brest centers were collected and analyzed to test the link between brain densities and PMIs.

Results

54 cases of naturally mummified corpses were included. The brains were classified as liquefied (56%), desiccated (17 %), DMO (20 %), and absent (7 %) based on their CT appearance. Dehydrated brains were significantly (p < 0.004) denser (median 102 HU, interquartile range (IQR) 41) than either liquefied brains (median 39.5 HU, IQR 9) or brains with DMO (median -25 HU, IQR 57). However, the density of brain remains was not significantly affected by where the bodies were found (p = 0,41). Analysis of PMI and brain densities was performed on 22 cases. The results showed that brain remains were significantly (p = 0.039) denser when they were found after a PMI of more than six months.

Conclusion

Brain desiccation was the aspect with the highest densities on PMCT, and for which we were able to highlight great preservation of anatomical structures observable in living organisms.

本研究旨在评估自然木乃伊尸体的头骨内容物、大脑外观和死后计算机断层扫描密度。为此，我们进行了一项回顾性多中心研究，包括来自法国两个中心（布雷斯特和南特）和美国新墨西哥州尸体图像数据库的木乃伊尸体，对2011年至2022年间发现的部分或全部木乃伊尸体的头部和颈部进行了尸检计算机断层扫描（PMCT）分析。PMCT 分析提供了有关大脑 CT 外观的数据，可将其分为四个不同类别（干燥、液化、仅硬脑膜 (DMO) 和缺失），并测量大脑残骸的密度（HU）。此外，还收集并分析了南特和布雷斯特中心的尸检间隔（PMI）数据，以检验大脑密度与尸检间隔之间的联系。54 具自然木乃伊化的尸体被纳入其中。根据其 CT 外观，大脑被分为液化（56%）、干瘪（17%）、DMO（20%）和缺失（7%）。脱水大脑的密度（中位数 102 HU，四分位数间距 (IQR) 41）明显高于液化大脑（中位数 39.5 HU，四分位数间距 9）或 DMO 大脑（中位数 -25 HU，四分位数间距 57）。然而，大脑残骸的密度并没有受到尸体发现地点的显著影响（= 0.41）。对 22 个病例进行了 PMI 和大脑密度分析。结果表明，在超过六个月的 PMI 之后发现的大脑残骸密度明显更高（= 0.039）。脑干化是 PMCT 密度最高的方面，我们能够突出显示活生物体解剖结构的巨大保存力。

{"title":"CT analysis of skull contents in naturally mummified human corpses, a multicentric study","authors":"Maëlle Guéganton-Lecat , Romain Provost , Tania Delabarde , Claire Saccardy , Mathilde Ducloyer , Douraied Ben Salem","doi":"10.1016/j.neurad.2024.04.001","DOIUrl":"10.1016/j.neurad.2024.04.001","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to assess skull contents, brain appearance, and density on postmortem computed tomography in naturally mummified corpses.</p></div><div><h3>Material and Methods</h3><p>For this purpose, a retrospective multicentric study, including mummified corpses from two French centers (Brest and Nantes) and from the New Mexico Decedent Image Database (USA), was performed by analyzing postmortem computed tomography (PMCT) focused on the head and neck of partially or fully mummified corpses discovered between 2011 and 2022. The PMCT analysis provided data on the CT appearance of brains, allowing them to be classified into four different categories (desiccation, liquefaction, dura mater only (DMO), and absence), and to measure densities (HU) of the brain remains. In addition, data on postmortem intervals (PMI) from Nantes and Brest centers were collected and analyzed to test the link between brain densities and PMIs.</p></div><div><h3>Results</h3><p>54 cases of naturally mummified corpses were included. The brains were classified as liquefied (56%), desiccated (17 %), DMO (20 %), and absent (7 %) based on their CT appearance. Dehydrated brains were significantly (<em>p</em> < 0.004) denser (median 102 HU, interquartile range (IQR) 41) than either liquefied brains (median 39.5 HU, IQR 9) or brains with DMO (median -25 HU, IQR 57). However, the density of brain remains was not significantly affected by where the bodies were found (<em>p</em> = 0,41). Analysis of PMI and brain densities was performed on 22 cases. The results showed that brain remains were significantly (<em>p</em> = 0.039) denser when they were found after a PMI of more than six months.</p></div><div><h3>Conclusion</h3><p>Brain desiccation was the aspect with the highest densities on PMCT, and for which we were able to highlight great preservation of anatomical structures observable in living organisms.</p></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140636375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low blood flow ratio is associated with hemorrhagic transformation secondary to mechanical thrombectomy in patients with acute ischemic stroke 低血流比与急性缺血性脑卒中患者继发于机械性血栓切除术的出血性转变有关

IF 3.5 3区医学 Q1 Medicine

Journal of Neuroradiology

Pub Date : 2024-04-04 DOI: 10.1016/j.neurad.2024.03.003

Lufei Feng , Mengying Yu , Mo Zheng , Wangle Huang , Fei Yao , Chaomin Qiu , Ru Lin , Ying Zhou , Haoyu Wu , Guoquan Cao , Dexing Kong , Yunjun Yang , Haoli Xu

Background and purpose

A significant decrease of cerebral blood flow (CBF) is a risk factor for hemorrhagic transformation (HT) in acute ischemic stroke (AIS). This study aimed to ascertain whether the ratio of different CBF thresholds derived from computed tomography perfusion (CTP) is an independent risk factor for HT after mechanical thrombectomy (MT).

Methods

A retrospective single center cohort study was conducted on patients with AIS undergoing MT at the First Affiliated Hospital of Wenzhou Medical University from August 2018 to December 2023. The perfusion parameters before thrombectomy were obtained according to CTP automatic processing software. The low blood flow ratio (LFR) was defined as the ratio of brain volume with relative CBF <20 % over volume with relative CBF <30 %. HT was evaluated on the follow-up CT images. Binary logistic regression was used to analyze the correlation between parameters that differ between the two groups with regards to HT occurrence. The predictive efficacy was assessed utilizing the receiver operating characteristic curve.

Results

In total, 243 patients met the inclusion criteria. During the follow-up, 46.5 % of the patients (113/243) developed HT. Compared with the Non-HT group, the HT group had a higher LFR (0.47 (0.34–0.65) vs. 0.32 (0.07–0.56); P < 0.001). According to the binary logistic regression analysis, the LFR (aOR: 6.737; 95 % CI: 1.994–22.758; P = 0.002), Hypertension history (aOR: 2.231; 95 % CI: 1.201–4.142; P = 0.011), plasma FIB levels before MT (aOR: 0.641; 95 % CI: 0.456–0.902; P = 0.011), and the mismatch ratio (aOR: 0.990; 95 % CI: 0.980–0.999; P = 0.030) were independently associated with HT secondary to MT. The area under the curve of the regression model for predicting HT was 0.741.

Conclusion

LFR, a ratio quantified via CTP, demonstrates potential as an independent risk factor of HT secondary to MT.

脑血流（CBF）明显减少是急性缺血性卒中（AIS）出血性转化（HT）的风险因素。本研究旨在确定计算机断层扫描灌注（CTP）得出的不同CBF阈值的比值是否是机械性血栓切除术（MT）后出血转化的独立风险因素。2018年8月至2023年12月，温州医科大学附属第一医院对接受MT的AIS患者进行了一项回顾性单中心队列研究。血栓切除术前的灌注参数根据CTP自动处理软件获得。低血流比（LFR）定义为相对 CBF <20 % 的脑容量与相对 CBF <30 % 的脑容量之比。随访 CT 图像对 HT 进行了评估。采用二元逻辑回归分析两组间不同参数与 HT 发生的相关性。利用接收者操作特征曲线评估了预测效果。共有 243 名患者符合纳入标准。在随访期间，46.5%的患者（113/243）发生了高血压。与非 HT 组相比，HT 组的 LFR 较高（0.47 (0.34-0.65) vs. 0.32 (0.07-0.56); < 0.001）。根据二元逻辑回归分析，LFR（aOR：6.737；95 % CI：1.994-22.758；= 0.002）、高血压病史（aOR：2.231；95 % CI：1.201-4.142；= 0.011）、MT 前血浆 FIB 水平（aOR：0.641；95 % CI：0.456-0.902；= 0.011）和错配比（aOR：0.990；95 % CI：0.980-0.999；= 0.030）与 MT 继发 HT 独立相关。预测 HT 的回归模型曲线下面积为 0.741。通过 CTP 量化的比值 LFR 有可能成为继发于 MT 的 HT 的独立风险因素。

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