Pub Date : 2025-06-01DOI: 10.1016/j.neurad.2025.101355
Ying Zhao , Han Yang , Siyi Yu , Ying Li , Leixiao Zhang
Background
Previous studies have found differences in spontaneous neural activity in multiple brain regions in CSU patients, such as the inferior orbitofrontal cortex. However, the current research on CSU patients is still dominated by brain region response, and there is a lack of evidence for the correlation between different brain regions. To elucidate the underlying mechanisms of interactions between different brain regions in CSU patients, we compared changes in FC between CSU patients and HCs.
Methods
53 patients with CSU and 31 HCs were recruited. The UAS7, VAS-P, DLQI, HAMA, and HAMD were collected to evaluate the changes in clinical symptoms in CSU. ORBinf-L was used as the seed point for whole brain FC analysis. Seed-based FC analysis was used to assess functional changes in the brain regions of the subjects.
Results
Compared with HCs, the FC values of the Caudate-L was increased in CSU patients, and the FC values was positively correlated with the VAS-P. CSU patients had decreased FC values in the Hippocampus-R, and were negatively correlated with the values of HAMA.
Conclusions
Our results revealed that CSU patients demonstrate aberrant connectivity in specific brain circuits—particularly the ORBinf-L to Caudate-L and ORBinf-L to Hippocampal-R pathways, which correlates with their pruritus severity and anxiety levels.
{"title":"Pruritus and anxiety symptoms in chronic spontaneous urticaria are associated with altered functional connectivity of the brain","authors":"Ying Zhao , Han Yang , Siyi Yu , Ying Li , Leixiao Zhang","doi":"10.1016/j.neurad.2025.101355","DOIUrl":"10.1016/j.neurad.2025.101355","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have found differences in spontaneous neural activity in multiple brain regions in CSU patients, such as the inferior orbitofrontal cortex. However, the current research on CSU patients is still dominated by brain region response, and there is a lack of evidence for the correlation between different brain regions. To elucidate the underlying mechanisms of interactions between different brain regions in CSU patients, we compared changes in FC between CSU patients and HCs.</div></div><div><h3>Methods</h3><div>53 patients with CSU and 31 HCs were recruited. The UAS7, VAS-P, DLQI, HAMA, and HAMD were collected to evaluate the changes in clinical symptoms in CSU. ORBinf-L was used as the seed point for whole brain FC analysis. Seed-based FC analysis was used to assess functional changes in the brain regions of the subjects.</div></div><div><h3>Results</h3><div>Compared with HCs, the FC values of the Caudate-L was increased in CSU patients, and the FC values was positively correlated with the VAS-P. CSU patients had decreased FC values in the Hippocampus-R, and were negatively correlated with the values of HAMA.</div></div><div><h3>Conclusions</h3><div>Our results revealed that CSU patients demonstrate aberrant connectivity in specific brain circuits—particularly the ORBinf-L to Caudate-L and ORBinf-L to Hippocampal-R pathways, which correlates with their pruritus severity and anxiety levels.</div></div><div><h3>Trial registration number</h3><div>ChiCTR2200064563</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101355"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.neurad.2025.101357
Nahum Antonio Alvarez-Ornelas , Hilda Elizabeth Macías-Cervantes , Patricia Rodríguez-Villaseñor , Omar Sánchez-Figueroa , Roberto Flores-Rodríguez , Zyanya Guadalupe García-Cisneros , Alberto Aguilar-Chávez , Oscar Pérez-Sánchez , Erica García-Valadez , Javier Medrano-Sánchez , Martha Alicia Hernández-González , José Guadalupe Rivera-Chávez
Background and purpose
Sleep is an essential physiological condition for the proper functioning of humans, both physiologically, cognitively, and psychologically. Sleep deprivation leads to a loss of psychomotor skills in humans. It is important to evaluate the structural changes experienced by medical residents who are sleep-deprived due to extensive work shifts, including night shifts, assigned during their training program. Therefore, the main outcome was to evaluate the structural changes in the cortical gray matter and the hippocampus assessed by brain magnetic resonance imaging (MRI) in newly admitted medical residents four months after the start of the medical specialty.
Material and methods
Forty-one newly admitted medical residents were enrolled, and an initial questionnaire was administered to assess sleep quality. All participants underwent a brain MRI study, utilizing an advanced MRI sequence: a 3D inversion recovery (IR)-prepped fast spoiled gradient-recalled (SPGR) high-resolution T1-weighted sequence. The images were then anonymized and reformatted, and volumetric analyses of gray matter and hippocampus were performed using an open-access platform for MRI brain analysis (volBrain). This process was repeated four months later with the acquisition of a new brain MRI study for each participant.
Results
For gray matter volume, a baseline value of 728.04 ± 63.95 cm³ and a final value of 715.11 ± 59.38 cm³ were found (p < 0.01), and the frontal lobe showed the greatest reduction, with an initial value of 181.92 ± 15.58 cm3 and a final volume of 176.45 ± 17.35 cm3 (p = <0.001). We found an OR of 1.52 (95 % CI 0.93–4.14, p = 0.01) between working night shifts and gray matter reduction.
Conclusions
The results of this study show a statistically significant reduction in gray matter volume in first-year residents after four months of shift work, with the greatest reduction in the frontal lobe.
{"title":"Sleep deprivation as a risk factor for cortical gray matter reduction in new medical residents","authors":"Nahum Antonio Alvarez-Ornelas , Hilda Elizabeth Macías-Cervantes , Patricia Rodríguez-Villaseñor , Omar Sánchez-Figueroa , Roberto Flores-Rodríguez , Zyanya Guadalupe García-Cisneros , Alberto Aguilar-Chávez , Oscar Pérez-Sánchez , Erica García-Valadez , Javier Medrano-Sánchez , Martha Alicia Hernández-González , José Guadalupe Rivera-Chávez","doi":"10.1016/j.neurad.2025.101357","DOIUrl":"10.1016/j.neurad.2025.101357","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Sleep is an essential physiological condition for the proper functioning of humans, both physiologically, cognitively, and psychologically. Sleep deprivation leads to a loss of psychomotor skills in humans. It is important to evaluate the structural changes experienced by medical residents who are sleep-deprived due to extensive work shifts, including night shifts, assigned during their training program. Therefore, the main outcome was to evaluate the structural changes in the cortical gray matter and the hippocampus assessed by brain magnetic resonance imaging (MRI) in newly admitted medical residents four months after the start of the medical specialty.</div></div><div><h3>Material and methods</h3><div>Forty-one newly admitted medical residents were enrolled, and an initial questionnaire was administered to assess sleep quality. All participants underwent a brain MRI study, utilizing an advanced MRI sequence: a 3D inversion recovery (IR)-prepped fast spoiled gradient-recalled (SPGR) high-resolution T1-weighted sequence. The images were then anonymized and reformatted, and volumetric analyses of gray matter and hippocampus were performed using an open-access platform for MRI brain analysis (volBrain). This process was repeated four months later with the acquisition of a new brain MRI study for each participant.</div></div><div><h3>Results</h3><div>For gray matter volume, a baseline value of 728.04 ± 63.95 cm³ and a final value of 715.11 ± 59.38 cm³ were found (<em>p</em> < 0.01), and the frontal lobe showed the greatest reduction, with an initial value of 181.92 ± 15.58 cm<sup>3</sup> and a final volume of 176.45 ± 17.35 cm<sup>3</sup> (<em>p</em> = <0.001). We found an OR of 1.52 (95 % CI 0.93–4.14, <em>p</em> = 0.01) between working night shifts and gray matter reduction.</div></div><div><h3>Conclusions</h3><div>The results of this study show a statistically significant reduction in gray matter volume in first-year residents after four months of shift work, with the greatest reduction in the frontal lobe.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101357"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.neurad.2025.101356
Ali Mortezaei , Ahmed Abdelsalam , Alireza Oladaskari , Ahmed Y. Azzam , MEng, Christina Tran , Sai Sanikommu , Tiffany Eatz , Michael A. Silva , Luis Guada , Caleigh S. Roach , Jayro Toledo , Gurkirat Singh Kohli , Derrek Schartz , Adam A Dmytriw , Redi Rahmani , Matthew Bender , Robert M. Starke
Background
Multiple studies have demonstrated lower access complications associated with transradial access (TRA) compared to transfemoral access (TFA) for endovascular procedures. The feasibility and safety of TRA versus TFA for mechanical thrombectomy (MT) for large vessel occlusions in acute ischemic stroke (AIS) is a subject of current debate.
Methods
We performed a systematic search in four databases. Binary outcomes were analyzed through odds ratios (OR) and 95 % confidence intervals (CI), while the continuous outcomes were analyzed through the standardized mean difference (SMD) and 95 % CI. Publication bias was visually assessed with a funnel plot and confirmed by Egger’s test.
Results
There were 5048 total patients undergoing MT from 15 studies in our analyses. In these patients, 984 MT were via TRA and 4064 via TFA. Access-site complications (OR = 0.16, P-value < 0.01) was significantly lower in TRA than TFA. No significant difference was found in 90-day functional independence (mRS 0–2) in the primary analysis (OR = 0.83, P = 0.23), although sensitivity analysis indicated significant difference after resolving heterogeneity. There were no statistically significant distinctions observed between the TRA group and TFA group concerning successful recanalization (OR = 1.07, P-value = 0.5), access-to-reperfusion time (MD = -2.4, P-value = 0.43), first-pass effect (OR = 0.84, P-value = 0.06), mean number of passes (MD = 0.032, P-value = 0.66), symptomatic intracerebral hemorrhage (OR = 0.95, P-value = 0.8), and 90-day mortality (OR = 1.24, P-value = 0.28).
Conclusion
TRA was associated with fewer access-site complications compared to TFA. Although no significant difference in 90-day functional independence was observed in the primary meta-analysis, sensitivity analysis indicated potential superiority of TFA. Our findings highlighted optimizing the patient selection to maximize the benefits of thrombectomy through radial access. Further randomized trials and prospective studies are required to confirm these findings.
{"title":"Radial vs femoral access in mechanical thrombectomy: Implications for clinical practice – A systematic review and meta-analysis","authors":"Ali Mortezaei , Ahmed Abdelsalam , Alireza Oladaskari , Ahmed Y. Azzam , MEng, Christina Tran , Sai Sanikommu , Tiffany Eatz , Michael A. Silva , Luis Guada , Caleigh S. Roach , Jayro Toledo , Gurkirat Singh Kohli , Derrek Schartz , Adam A Dmytriw , Redi Rahmani , Matthew Bender , Robert M. Starke","doi":"10.1016/j.neurad.2025.101356","DOIUrl":"10.1016/j.neurad.2025.101356","url":null,"abstract":"<div><h3>Background</h3><div>Multiple studies have demonstrated lower access complications associated with transradial access (TRA) compared to transfemoral access (TFA) for endovascular procedures. The feasibility and safety of TRA versus TFA for mechanical thrombectomy (MT) for large vessel occlusions in acute ischemic stroke (AIS) is a subject of current debate.</div></div><div><h3>Methods</h3><div>We performed a systematic search in four databases. Binary outcomes were analyzed through odds ratios (OR) and 95 % confidence intervals (CI), while the continuous outcomes were analyzed through the standardized mean difference (SMD) and 95 % CI. Publication bias was visually assessed with a funnel plot and confirmed by Egger’s test.</div></div><div><h3>Results</h3><div>There were 5048 total patients undergoing MT from 15 studies in our analyses. In these patients, 984 MT were via TRA and 4064 via TFA. Access-site complications (OR = 0.16, P-value < 0.01) was significantly lower in TRA than TFA. No significant difference was found in 90-day functional independence (mRS 0–2) in the primary analysis (OR = 0.83, <em>P</em> = 0.23), although sensitivity analysis indicated significant difference after resolving heterogeneity. There were no statistically significant distinctions observed between the TRA group and TFA group concerning successful recanalization (OR = 1.07, P-value = 0.5), access-to-reperfusion time (MD = -2.4, P-value = 0.43), first-pass effect (OR = 0.84, P-value = 0.06), mean number of passes (MD = 0.032, P-value = 0.66), symptomatic intracerebral hemorrhage (OR = 0.95, P-value = 0.8), and 90-day mortality (OR = 1.24, P-value = 0.28).</div></div><div><h3>Conclusion</h3><div>TRA was associated with fewer access-site complications compared to TFA. Although no significant difference in 90-day functional independence was observed in the primary meta-analysis, sensitivity analysis indicated potential superiority of TFA. Our findings highlighted optimizing the patient selection to maximize the benefits of thrombectomy through radial access. Further randomized trials and prospective studies are required to confirm these findings.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 5","pages":"Article 101356"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-24DOI: 10.1016/j.neurad.2025.101352
J. Gossner
{"title":"CT- guided erector spinae plane block for low back pain: A technical note","authors":"J. Gossner","doi":"10.1016/j.neurad.2025.101352","DOIUrl":"10.1016/j.neurad.2025.101352","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101352"},"PeriodicalIF":3.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-24DOI: 10.1016/j.neurad.2025.101354
Vichyat Var , Severina M. Leu , Nikki Rommers , Marios N. Psychogios , Dominik Cordier , Ramona A. Todea
Purpose
This study investigates the diagnostic accuracy of combined Golden Angle Radial Sparse Parallel Dynamic contrast-enhanced (GRASP DCE-) and Dynamic susceptibility contrast (DSC) MRI in differentiating PD from PsP following RCT in differentiating progressive disease (PD) from pseudoprogression (PsP) following radiochemotherapy (RCT) in glioblastoma patients.
Materials and methods
This retrospective study included glioblastoma patients who underwent surgery and RCT between 2017 and 2021 and developed contrast-enhancing lesions suspicious for PD or PsP and had GRASP DCE- and DSC-MRI. Diagnostic accuracy of perfusion parameters was evaluated using the area under the receiver operating characteristics curve (AUC) at both initial suspicion of progression and confirmation MRI.
Results
Among 83 patients, 62 were classified as PD and 21 as PsP on serial MRI for all patients, with additional histological confirmation in 18 patients. Median perfusion parameters values were higher in the PD group in comparison to the PsP group (rCBV: 3.48 vs. 1.60, p < .001; Vp: 0.08 vs. 0.05, p = .032). At initial suspicion of progression, the combination of Ktrans, Ve, Vp and rCBV improved diagnostic accuracy in differentiating PD from PsP (AUC = 0.77, 95 % CI [0.62–0.93]) compared to rCBV alone (AUC = 0.69, 95 % CI [0.54–0.85]). At confirmation MRI (>12 weeks post-RCT), the added value of DCE was more modest (AUC improvement from 0.88 to 0.90). Suggested optimal thresholds at confirmation were: rCBV 2.87 (Sensitivity 71 %, Specificity 94 %), Ktrans 0.12 min-1 (73 %, 76 %), Ve 0.31 (75 %, 65 %), and Vp 0.05 (78 %, 59 %).
Conclusion
Combining DCE- with DSC-MRI may enhance diagnostic accuracy in distinguishing progressive disease from pseudoprogression in glioblastoma, particularly during the early post-radiochemotherapy phase when treatment decisions are critical. As the added value of DCE-MRI is limited beyond 12 weeks post-radiochemotherapy, the full protocol is best reserved for early suspicion of progression or unclear cases, while DSC-MRI alone may be sufficient for confirmation imaging after this period.
目的：探讨黄金角径向稀疏平行动态对比增强（GRASP DCE-）与动态敏感性对比（DSC） MRI联合应用在胶质母细胞瘤放化疗（RCT）后进展性疾病（PD）与假性进展（PsP）鉴别PD与PsP的诊断准确性。材料和方法：本回顾性研究纳入了2017年至2021年间接受手术和RCT的胶质母细胞瘤患者，这些患者出现了怀疑PD或PsP的对比增强病变，并进行了GRASP DCE-和DSC-MRI检查。灌注参数的诊断准确性在最初怀疑进展和确认MRI时使用受者工作特征曲线下面积（AUC）进行评估。结果：83例患者中，所有患者的MRI序列显示62例为PD， 21例为PsP，另有18例患者的组织学证实。PD组灌注参数中位数值高于PsP组(rCBV: 3.48 vs. 1.60, p < 0.001；Vp: 0.08 vs. 0.05, p = .032)。在最初怀疑进展时，与单独使用rCBV （AUC = 0.69,95% CI[0.54-0.85]）相比，Ktrans、Ve、Vp和rCBV联合使用可提高PD与PsP的诊断准确性（AUC = 0.77,95% CI[0.62-0.93]）。在MRI确认时（rct后12周），DCE的附加值更为温和（AUC从0.88改善到0.90）。建议的最佳确认阈值为：rCBV 2.87（敏感性71%，特异性94%），Ktrans 0.12 (73%, 76%), Ve 0.31 (75%, 65%), Vp 0.06（79%, 59%）。结论：DCE-联合DSC-MRI可提高胶质母细胞瘤进行性疾病和假进展的诊断准确性，特别是在放化疗后早期，治疗决策至关重要。由于放化疗后12周后DCE-MRI的附加价值有限，因此完整方案最好用于早期怀疑进展或不明确的病例，而在此期间后仅DSC-MRI可能足以进行确认成像。
{"title":"Differentiation of tumor progression from pseudoprogression in glioblastoma patients with GRASP DCE-MRI and DSC-MRI","authors":"Vichyat Var , Severina M. Leu , Nikki Rommers , Marios N. Psychogios , Dominik Cordier , Ramona A. Todea","doi":"10.1016/j.neurad.2025.101354","DOIUrl":"10.1016/j.neurad.2025.101354","url":null,"abstract":"<div><h3>Purpose</h3><div>This study investigates the diagnostic accuracy of combined Golden Angle Radial Sparse Parallel Dynamic contrast-enhanced (GRASP DCE-) and Dynamic susceptibility contrast (DSC) MRI in differentiating PD from PsP following RCT in differentiating progressive disease (PD) from pseudoprogression (PsP) following radiochemotherapy (RCT) in glioblastoma patients.</div></div><div><h3>Materials and methods</h3><div>This retrospective study included glioblastoma patients who underwent surgery and RCT between 2017 and 2021 and developed contrast-enhancing lesions suspicious for PD or PsP and had GRASP DCE- and DSC-MRI. Diagnostic accuracy of perfusion parameters was evaluated using the area under the receiver operating characteristics curve (AUC) at both initial suspicion of progression and confirmation MRI.</div></div><div><h3>Results</h3><div>Among 83 patients, 62 were classified as PD and 21 as PsP on serial MRI for all patients, with additional histological confirmation in 18 patients. Median perfusion parameters values were higher in the PD group in comparison to the PsP group (rCBV: 3.48 vs. 1.60, p < .001; Vp: 0.08 vs. 0.05, p = .032). At initial suspicion of progression, the combination of Ktrans, Ve, Vp and rCBV improved diagnostic accuracy in differentiating PD from PsP (AUC = 0.77, 95 % CI [0.62–0.93]) compared to rCBV alone (AUC = 0.69, 95 % CI [0.54–0.85]). At confirmation MRI (>12 weeks post-RCT), the added value of DCE was more modest (AUC improvement from 0.88 to 0.90). Suggested optimal thresholds at confirmation were: rCBV 2.87 (Sensitivity 71 %, Specificity 94 %), Ktrans 0.12 min<sup>-1</sup> (73 %, 76 %), Ve 0.31 (75 %, 65 %), and Vp 0.05 (78 %, 59 %).</div></div><div><h3>Conclusion</h3><div>Combining DCE- with DSC-MRI may enhance diagnostic accuracy in distinguishing progressive disease from pseudoprogression in glioblastoma, particularly during the early post-radiochemotherapy phase when treatment decisions are critical. As the added value of DCE-MRI is limited beyond 12 weeks post-radiochemotherapy, the full protocol is best reserved for early suspicion of progression or unclear cases, while DSC-MRI alone may be sufficient for confirmation imaging after this period.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101354"},"PeriodicalIF":3.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-24DOI: 10.1016/j.neurad.2025.101353
Alexander A. Oliver , Julien Ognard , Jonathan Cortese , Esref A. Bayraktar , Aleksandra M. Zielonka , David F. Kallmes , Brandon J. Tefft , Ramanathan Kadirvel
Flow diverters are effective endovascular devices used to treat intracranial aneurysms by facilitating aneurysm occlusion through endothelial growth across the aneurysm neck. Rapid endothelialization reduces complications such as thrombosis and stenosis. This technical note describes braided, magnetizable flow diverters made from stainless steel alloy 2205 (SS2205) wires designed to magnetically capture autologous blood outgrowth endothelial cells (BOECs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs). Preclinical rabbit artery deployments demonstrated successful magnetic capture and retention of SPION-labeled BOECs, indicating feasibility for accelerated endothelialization. Detailed technical specifications provided in this manuscript ensure precise reproducibility, aiding future studies exploring advanced endothelialization strategies in neuroradiology.
{"title":"Magnetizable flow diverters can magnetically capture and retain endothelial cells to promote healing in rabbit arteries","authors":"Alexander A. Oliver , Julien Ognard , Jonathan Cortese , Esref A. Bayraktar , Aleksandra M. Zielonka , David F. Kallmes , Brandon J. Tefft , Ramanathan Kadirvel","doi":"10.1016/j.neurad.2025.101353","DOIUrl":"10.1016/j.neurad.2025.101353","url":null,"abstract":"<div><div>Flow diverters are effective endovascular devices used to treat intracranial aneurysms by facilitating aneurysm occlusion through endothelial growth across the aneurysm neck. Rapid endothelialization reduces complications such as thrombosis and stenosis. This technical note describes braided, magnetizable flow diverters made from stainless steel alloy 2205 (SS2205) wires designed to magnetically capture autologous blood outgrowth endothelial cells (BOECs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs). Preclinical rabbit artery deployments demonstrated successful magnetic capture and retention of SPION-labeled BOECs, indicating feasibility for accelerated endothelialization. Detailed technical specifications provided in this manuscript ensure precise reproducibility, aiding future studies exploring advanced endothelialization strategies in neuroradiology.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101353"},"PeriodicalIF":3.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interventional neuroradiology in France in 2025: Scaling up expertise, access, and innovation","authors":"Julien Burel, Thibault Agripnidis, Aymeric Rouchaud, Gaultier Marnat, Jildaz Caroff, François Zhu, Basile Kerleroux, Jérôme Berge, Jean-Pierre Pruvo, Hubert Desal, Grégoire Boulouis , SFNR Board","doi":"10.1016/j.neurad.2025.101350","DOIUrl":"10.1016/j.neurad.2025.101350","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101350"},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-14DOI: 10.1016/j.neurad.2025.101351
Thomas J. Vogl , Leon Vincent Stein , Claus Rödel , John Bielfeldt , Hamzah Adwan
Background
To retrospectively analyze the safety and efficacy of intra-arterial chemoperfusion (IAC) for symptomatic patients with recurrent or post-therapeutic progressive primary malignant brain tumors in regard to safety, survival and therapy response as a palliative treatment.
Methods
Thirty-nine patients (24 men, 15 women; mean age: 52) who were treated by IAC in 181 sessions (mean: 4.6 sessions/patient) were enrolled and evaluated in this study. Out of total 39 patients with primary malignant brain tumor, 27 (69 %) were diagnosed with glioblastoma. The overall survival (OS) was calculated using the Kaplan-Meier method. Therapy response was determined according to RECIST 1.1.
Results
All IAC treatments were performed without major adverse events or treatment-related deaths. The median OS time was 10.3 months (95 %CI: 0.6 – 19.9). The median PFS time was 5.9 months (95 %CI: 3.6 – 8.3). The rate of partial response was 10.8 % (4/37) and stable disease was achieved in 56.8 % (21/37) of patients. Progressive disease was observed in 32.4 % of cases (12/37). There were no cases of complete response. In two cases RECIST could not be analyzed due to loss of radiological follow-up.
Conclusion
This study could show that IAC may serve as a safe palliative strategy for symptomatic patients with recurrent or post-therapeutic progressive primary malignant brain tumors.
{"title":"Efficacy and safety of intra-arterial chemoperfusion as palliative treatment of symptomatic primary brain malignancies","authors":"Thomas J. Vogl , Leon Vincent Stein , Claus Rödel , John Bielfeldt , Hamzah Adwan","doi":"10.1016/j.neurad.2025.101351","DOIUrl":"10.1016/j.neurad.2025.101351","url":null,"abstract":"<div><h3>Background</h3><div>To retrospectively analyze the safety and efficacy of intra-arterial chemoperfusion (IAC) for symptomatic patients with recurrent or post-therapeutic progressive primary malignant brain tumors in regard to safety, survival and therapy response as a palliative treatment.</div></div><div><h3>Methods</h3><div>Thirty-nine patients (24 men, 15 women; mean age: 52) who were treated by IAC in 181 sessions (mean: 4.6 sessions/patient) were enrolled and evaluated in this study. Out of total 39 patients with primary malignant brain tumor, 27 (69 %) were diagnosed with glioblastoma. The overall survival (OS) was calculated using the Kaplan-Meier method. Therapy response was determined according to RECIST 1.1.</div></div><div><h3>Results</h3><div>All IAC treatments were performed without major adverse events or treatment-related deaths. The median OS time was 10.3 months (95 %CI: 0.6 – 19.9). The median PFS time was 5.9 months (95 %CI: 3.6 – 8.3). The rate of partial response was 10.8 % (4/37) and stable disease was achieved in 56.8 % (21/37) of patients. Progressive disease was observed in 32.4 % of cases (12/37). There were no cases of complete response. In two cases RECIST could not be analyzed due to loss of radiological follow-up.</div></div><div><h3>Conclusion</h3><div>This study could show that IAC may serve as a safe palliative strategy for symptomatic patients with recurrent or post-therapeutic progressive primary malignant brain tumors.</div></div>","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101351"},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-08DOI: 10.1016/j.neurad.2025.101348
Laura Tello Arnas , Andres Javier Barrios López , Alberto Álvarez Muelas , Celia Del Peso Ley , Andrés Francisco Fernández Prieto , Pedro Navia Álvarez
{"title":"Application of optical neuronavigation in interventional neuroradiology","authors":"Laura Tello Arnas , Andres Javier Barrios López , Alberto Álvarez Muelas , Celia Del Peso Ley , Andrés Francisco Fernández Prieto , Pedro Navia Álvarez","doi":"10.1016/j.neurad.2025.101348","DOIUrl":"10.1016/j.neurad.2025.101348","url":null,"abstract":"","PeriodicalId":50115,"journal":{"name":"Journal of Neuroradiology","volume":"52 4","pages":"Article 101348"},"PeriodicalIF":3.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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