Pub Date : 2024-06-21DOI: 10.1101/2024.06.18.24309139
Woo-Chul Shin, Se yun Kim, Whisung Cho, Jaehyun Park, Hyungsuk Kim, Won-Seok Chung, Mi-Yeon Song, Jae-Heung Cho
Introduction Temporomandibular disorders (TMD) are a group of conditions that affect the temporomandibular joint, masticatory muscles, and associated structures, often leading to pain, dysfunction, and a significant impact on quality of life. Epidemiological studies have estimated that up to 75% of the population in the United States exhibit at least one sign of TMD. Although conservative treatments such as acupuncture and occlusal splints have been recommended, evidence for their effectiveness remains inconclusive, and the combined effects of these interventions are not well understood. This study aims to compare the efficacy of an intraoral balance appliance (IBA) combined with standard Korean medicine care versus Korean medicine care alone in patients with chronic, painful TMD with myalgia. Materials and Methods A single-center, two-arm, parallel, evaluator-blinded, randomized controlled trial (RCT) with a 1:1 allocation ratio will be designed to test the interventions. Seventy-six TMD patients with myalgia will be recruited and randomized. The Interventions will include manual acupuncture and physical therapy in both groups, with the addition of IBA in the treatment group. Discussion The outcomes will be measured using various scales such as the numeric rating scale for pain and bothersomeness, jaw functional limitation scale, and quality of life indicators. Conclusion The trial is expected to provide evidence of the efficacy of combining the usual Korean medicine care and IBA in managing chronic TMD myalgia. Despite certain limitations such as the short intervention period and lack of standardized splint therapy, this RCT will contribute valuable data to guide the future treatment of TMD with myalgia.
{"title":"Effect of Adjunctive Intraoral Balance Appliance in the Usual Care of Patients with Chronic Temporomandibular Joint Disorders using Korean Medicine: Study Protocol for a Randomized Controlled Trial","authors":"Woo-Chul Shin, Se yun Kim, Whisung Cho, Jaehyun Park, Hyungsuk Kim, Won-Seok Chung, Mi-Yeon Song, Jae-Heung Cho","doi":"10.1101/2024.06.18.24309139","DOIUrl":"https://doi.org/10.1101/2024.06.18.24309139","url":null,"abstract":"Introduction Temporomandibular disorders (TMD) are a group of conditions that affect the temporomandibular joint, masticatory muscles, and associated structures, often leading to pain, dysfunction, and a significant impact on quality of life. Epidemiological studies have estimated that up to 75% of the population in the United States exhibit at least one sign of TMD. Although conservative treatments such as acupuncture and occlusal splints have been recommended, evidence for their effectiveness remains inconclusive, and the combined effects of these interventions are not well understood.\u0000This study aims to compare the efficacy of an intraoral balance appliance (IBA) combined with standard Korean medicine care versus Korean medicine care alone in patients with chronic, painful TMD with myalgia. Materials and Methods A single-center, two-arm, parallel, evaluator-blinded, randomized controlled trial (RCT) with a 1:1 allocation ratio will be designed to test the interventions. Seventy-six TMD patients with myalgia will be recruited and randomized. The Interventions will include manual acupuncture and physical therapy in both groups, with the addition of IBA in the treatment group. Discussion The outcomes will be measured using various scales such as the numeric rating scale for pain and bothersomeness, jaw functional limitation scale, and quality of life indicators. Conclusion The trial is expected to provide evidence of the efficacy of combining the usual Korean medicine care and IBA in managing chronic TMD myalgia. Despite certain limitations such as the short intervention period and lack of standardized splint therapy, this RCT will contribute valuable data to guide the future treatment of TMD with myalgia.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-21DOI: 10.1101/2024.06.21.24309281
Muneer Yaqub, Chisom Promise Nnamani
Objective: This study aims to evaluate the oral hygiene practices and their effectiveness in preventing common oral diseases among the residents of the Akpugo community in Enugu State, Nigeria. Methods: A cross-sectional survey was conducted among 150 randomly selected participants from the five villages of Akpugo. Data collection involved personal interviews and physical examinations of oral cavities using sterilized instruments. The analysis included percentage calculations, z-tests, and the categorization of participants by socio-economic groups based on age and gender. Results: The study revealed a high prevalence of oral diseases, with 29.3% of participants having dental caries, 19.3% suffering from halitosis, 18% diagnosed with gingivitis, and 10% with periodontitis. Most participants (90.7%) brushed their teeth once daily, predominantly in the morning, and only 5.3% brushed twice daily. A majority used toothbrushes and toothpaste (58%), while a significant portion still relied on traditional methods such as chewing sticks (26.67%). The presence of dental calculus was observed in 47.3% of participants, with dental plaque noted in 16.7%. Conclusion: The findings highlight a significant prevalence of poor oral health despite varying levels of awareness regarding preventive practices. The study underscores the need for targeted interventions, including comprehensive oral health education programs, the establishment of dental centers, and community-led initiatives to improve oral hygiene practices. These measures are crucial for reducing the incidence of oral diseases and enhancing the overall health and well-being of the Akpugo community. The study emphasizes the importance of continuous education and intervention to promote optimal oral health in rural areas.
{"title":"Oral Hygiene Practices and Their Impact on Oral Health Among the Indigenes of Akpugo Community in Enugu State, Nigeria","authors":"Muneer Yaqub, Chisom Promise Nnamani","doi":"10.1101/2024.06.21.24309281","DOIUrl":"https://doi.org/10.1101/2024.06.21.24309281","url":null,"abstract":"Objective: This study aims to evaluate the oral hygiene practices and their effectiveness in preventing common oral diseases among the residents of the Akpugo community in Enugu State, Nigeria. Methods: A cross-sectional survey was conducted among 150 randomly selected participants from the five villages of Akpugo. Data collection involved personal interviews and physical examinations of oral cavities using sterilized instruments. The analysis included percentage calculations, z-tests, and the categorization of participants by socio-economic groups based on age and gender. Results: The study revealed a high prevalence of oral diseases, with 29.3% of participants having dental caries, 19.3% suffering from halitosis, 18% diagnosed with gingivitis, and 10% with periodontitis. Most participants (90.7%) brushed their teeth once daily, predominantly in the morning, and only 5.3% brushed twice daily. A majority used toothbrushes and toothpaste (58%), while a significant portion still relied on traditional methods such as chewing sticks (26.67%). The presence of dental calculus was observed in 47.3% of participants, with dental plaque noted in 16.7%. Conclusion: The findings highlight a significant prevalence of poor oral health despite varying levels of awareness regarding preventive practices. The study underscores the need for targeted interventions, including comprehensive oral health education programs, the establishment of dental centers, and community-led initiatives to improve oral hygiene practices. These measures are crucial for reducing the incidence of oral diseases and enhancing the overall health and well-being of the Akpugo community. The study emphasizes the importance of continuous education and intervention to promote optimal oral health in rural areas.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Artificial intelligence (AI) language models have shown potential as educational tools in healthcare, but their accuracy and reliability in periodontology education require further evaluation. In this study we aimed to assess and compare the performance of three prominent AI language models—ChatGPT-4o, Claude 3 Opus, and Gemini Advanced—with second-year periodontics residents across the United States on the American Academy of Periodontology 2024 in-service examination.
背景 人工智能（AI）语言模型已显示出作为医疗保健领域教育工具的潜力，但其在牙周病学教育中的准确性和可靠性还需要进一步评估。在本研究中，我们旨在评估和比较三种著名的人工智能语言模型--ChatGPT-4o、Claude 3 Opus 和 Gemini Advanced 在美国牙周病学会 2024 年在职考试中的表现。
{"title":"Artificial Intelligence in Periodontology: Performance Evaluation of ChatGPT, Claude, and Gemini on the In-service Examination","authors":"Bushra Ahmad, Khaled Saleh, Saleh Alharbi, Hend Alqaderi, Y. Natalie Jeong","doi":"10.1101/2024.05.29.24308155","DOIUrl":"https://doi.org/10.1101/2024.05.29.24308155","url":null,"abstract":"<strong>Background</strong> Artificial intelligence (AI) language models have shown potential as educational tools in healthcare, but their accuracy and reliability in periodontology education require further evaluation. In this study we aimed to assess and compare the performance of three prominent AI language models—ChatGPT-4o, Claude 3 Opus, and Gemini Advanced—with second-year periodontics residents across the United States on the American Academy of Periodontology 2024 in-service examination.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141257252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-29DOI: 10.1101/2024.05.29.24308111
Katherine Kwong, You Lu, ZhuoHuan Li, Ting Luo, Zhaoyu Huang, Na Zhao, Tung-Sung Tseng
Purpose Periodontitis in older adults is a public health issue. There is a growing population of older adults in the United States; furthermore, the proportion of the population of older adults who identify as a racial minority are growing at a faster rate than non-minority identifying older adults. Sufficient lycopene intake is one potential solution for individuals who express reluctance and/or an inability to access preventative oral care particularly by older adults who self-identify as a racial minority, leading to lower levels of periodontitis if they consume a sufficient amount of lycopene. The objective of this paper is to explore the association between insufficient lycopene intake and risk of periodontitis among older adults.
{"title":"Race and gender disparity of dietary lycopene intake and periodontitis severity in older adults","authors":"Katherine Kwong, You Lu, ZhuoHuan Li, Ting Luo, Zhaoyu Huang, Na Zhao, Tung-Sung Tseng","doi":"10.1101/2024.05.29.24308111","DOIUrl":"https://doi.org/10.1101/2024.05.29.24308111","url":null,"abstract":"<strong>Purpose</strong> Periodontitis in older adults is a public health issue. There is a growing population of older adults in the United States; furthermore, the proportion of the population of older adults who identify as a racial minority are growing at a faster rate than non-minority identifying older adults. Sufficient lycopene intake is one potential solution for individuals who express reluctance and/or an inability to access preventative oral care particularly by older adults who self-identify as a racial minority, leading to lower levels of periodontitis if they consume a sufficient amount of lycopene. The objective of this paper is to explore the association between insufficient lycopene intake and risk of periodontitis among older adults.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141189691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-28DOI: 10.1101/2024.05.28.24308014
Ruben Pauwels
Objective To develop an accurate method for converting dose-area product (DAP) to patient dose for dental cone-beam computed tomography (CBCT) using deep learning.
{"title":"Converting dose-area product to effective dose in dental cone-beam computed tomography using organ-specific deep learning","authors":"Ruben Pauwels","doi":"10.1101/2024.05.28.24308014","DOIUrl":"https://doi.org/10.1101/2024.05.28.24308014","url":null,"abstract":"<strong>Objective</strong> To develop an accurate method for converting dose-area product (DAP) to patient dose for dental cone-beam computed tomography (CBCT) using deep learning.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141189634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-06DOI: 10.1101/2024.05.05.24306865
T.L. Finlayson, K. Moss, J.A. Jones, J.S. Preisser, J.A. Weintraub
Objective Psychosocial factors can affect health. Patterns of psychosocial stressors and resources among older adults were examined for oral health status.
目的 社会心理因素会影响健康。我们针对老年人的口腔健康状况，研究了他们的社会心理压力和资源模式。
{"title":"Psychosocial Profiles of Older Adults by Dentition Status and Dental Utilization History","authors":"T.L. Finlayson, K. Moss, J.A. Jones, J.S. Preisser, J.A. Weintraub","doi":"10.1101/2024.05.05.24306865","DOIUrl":"https://doi.org/10.1101/2024.05.05.24306865","url":null,"abstract":"<strong>Objective</strong> Psychosocial factors can affect health. Patterns of psychosocial stressors and resources among older adults were examined for oral health status.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140935441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-06DOI: 10.1101/2024.05.05.24306900
Alain Manuel Chaple Gil, Solanch de la Caridad Damas Heredia, Kelvin I. Afrashtehfar
The objective of this article was to compile the computer tools available in the scientific literature aimed at diagnosis in dentistry. An scoping review research was conducted in Pubmed, Scopus and Web of Science. Were include, original researches type articles, Articles that reported the usefulness of a computer/technological tool that helps diagnosis in dental practice, Articles published in the last 20 years (period 2004-2024) and written in English and Spanish. Online tool Rayyan® was used to establish homogeneity in the review of the authors on a single online platform where they had access and could centralize the results. Variables were extracted from each article included in the study. A total of 12648 records were recuperated from data bases. After decantation process were included 39 reports that described 36 computer tools for diagnosis in dentistry. More informatic tools related to "Restorative Dentistry" have been developed than the rest of the specialties 14 (40%), Python was the predominant programming language, 83.3% of the tools were validated and 27.8% were free. Informatics tools in dentistry enhance diagnosis and treatment planning. However, a robust regulatory framework is needed for their validation before clinical implementation. Continuous training of dental professionals in these technologies is crucial to maximize their benefits and ensure optimal patient care. The need for more research to explore the potential of informatics applications in dentistry, their integration into existing health systems, and their accessibility in resource-limited areas is emphasized.
{"title":"Informatic tools for diagnosis in dentistry. A compilation review","authors":"Alain Manuel Chaple Gil, Solanch de la Caridad Damas Heredia, Kelvin I. Afrashtehfar","doi":"10.1101/2024.05.05.24306900","DOIUrl":"https://doi.org/10.1101/2024.05.05.24306900","url":null,"abstract":"The objective of this article was to compile the computer tools available in the scientific literature aimed at diagnosis in dentistry. An scoping review research was conducted in <em>Pubmed</em>, <em>Scopus</em> and <em>Web of Science</em>. Were include, original researches type articles, Articles that reported the usefulness of a computer/technological tool that helps diagnosis in dental practice, Articles published in the last 20 years (period 2004-2024) and written in English and Spanish. Online tool <em>Rayyan®</em> was used to establish homogeneity in the review of the authors on a single online platform where they had access and could centralize the results. Variables were extracted from each article included in the study. A total of 12648 records were recuperated from data bases. After decantation process were included 39 reports that described 36 computer tools for diagnosis in dentistry. More informatic tools related to \"Restorative Dentistry\" have been developed than the rest of the specialties 14 (40%), Python was the predominant programming language, 83.3% of the tools were validated and 27.8% were free. Informatics tools in dentistry enhance diagnosis and treatment planning. However, a robust regulatory framework is needed for their validation before clinical implementation. Continuous training of dental professionals in these technologies is crucial to maximize their benefits and ensure optimal patient care. The need for more research to explore the potential of informatics applications in dentistry, their integration into existing health systems, and their accessibility in resource-limited areas is emphasized.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140935409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-05DOI: 10.1101/2024.05.03.24306821
Vanessa Gallego Arias Pecorari, Laís Renata Almeida Cezário, Caio Vieira de Barros Arato, Tainá de Lima Costa, Karine Laura Cortellazzi, Roberto Fiório Pecorari, José Erasmo Silva
Background The use of Artificial Intelligence (AI) has many applications in the healthcare field. Dental caries is a disease with a prevalence rate of over 50% in Brazil. The diagnosis of caries is usually based on a clinical examination and supplementary tests such as X-rays. The accuracy of a diagnostic test is evaluated by its sensitivity, specificity, and accuracy. Various algorithms and neural network configurations are being used for caries diagnosis.
背景 人工智能（AI）在医疗保健领域有许多应用。在巴西，龋齿的发病率超过 50%。龋齿的诊断通常基于临床检查和 X 射线等辅助检查。诊断测试的准确性是通过其灵敏度、特异性和准确性来评估的。各种算法和神经网络配置正被用于龋齿诊断。
{"title":"The use of artificial intelligence in the diagnosis of carious lesions: Systematic review and meta-analysis","authors":"Vanessa Gallego Arias Pecorari, Laís Renata Almeida Cezário, Caio Vieira de Barros Arato, Tainá de Lima Costa, Karine Laura Cortellazzi, Roberto Fiório Pecorari, José Erasmo Silva","doi":"10.1101/2024.05.03.24306821","DOIUrl":"https://doi.org/10.1101/2024.05.03.24306821","url":null,"abstract":"<strong>Background</strong> The use of Artificial Intelligence (AI) has many applications in the healthcare field. Dental caries is a disease with a prevalence rate of over 50% in Brazil. The diagnosis of caries is usually based on a clinical examination and supplementary tests such as X-rays. The accuracy of a diagnostic test is evaluated by its sensitivity, specificity, and accuracy. Various algorithms and neural network configurations are being used for caries diagnosis.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140935436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-09DOI: 10.1101/2024.04.07.24305400
The International ORAL Consortium, Amy C. Moreno, Erin E. Watson, Laia Humbert-Vidan, Douglas E. Peterson, Lisanne V van Dijk, Teresa Guerrero Urbano, Lisa Van den Bosch, Andrew J. Hope, Matthew S. Katz, Frank J.P. Hoebers, Ruth A. Aponte Wesson, James E. Bates, Paolo Bossi, Adeyinka F. Dayo, Mélanie Doré, Eduardo Rodrigues Fregnani, Thomas J. Galloway, Daphna Y. Gelblum, Issa A. Hanna, Christina E. Henson, Sudarat Kiat-amnuay, Anke Korfage, Nancy Y. Lee, Carol M. Lewis, Charlotte Duch Lynggaard, Antti A. Mäkitie, Marco Magalhaes, Yvonne M. Mowery, Carles Muñoz-Montplet, Jeffrey N. Myers, Ester Orlandi, Jaymit Patel, Jillian M. Rigert, Deborah Saunders, Jonathan D. Schoenfeld, Ugur Selek, Efsun Somay, Vinita Takiar, Juliette Thariat, Gerda M. Verduijn, Alessandro Villa, Nick West, Max J.H. Witjes, Alex Won, Mark E. Wong, Christopher M.K.L. Yao, Simon W. Young, Kamal Al-eryani, Carly E.A. Barbon, Doke J.M. Buurman, François J. Dieleman, Theresa M. Hofstede, Abdul Ahad Khan, Adegbenga O. Otun, John C. Robinson, Lauren Hum, Jorgen Johansen, Rajesh Lalla, Alexander Lin, Vinod Patel, Richard J. Shaw, Mark S. Chambers, Daniel Ma, Mabi Singh, Noam Yarom, Abdallah Sherif Radwan Mohamed, Katherine A. Hutcheson, Stephen Y. Lai, Clifton David Fuller
Purpose Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to the head and neck. With over 9 published definitions and at least 16 diagnostic/staging systems, the true incidence and severity of ORNJ are obscured by lack of a standard for disease definition and severity assessment, leading to inaccurate estimation of incidence, reporting ambiguity, and likely under-diagnosis worldwide. This study aimed to achieve consensus on an explicit definition and phenotype of ORNJ and related precursor states through data standardization to facilitate effective diagnosis, monitoring, and multidisciplinary management of ORNJ.
目的 下颌骨骨坏死（Osteoradionecrosis of the jaw，ORNJ）是一种严重的先天性疾病，其特点是头颈部接受放射治疗（RT）后出现骨坏死。目前已公布的ORNJ定义有9种之多，诊断/分期系统至少有16种，但由于缺乏疾病定义和严重程度评估的标准，ORNJ的真实发病率和严重程度被掩盖了，导致全球范围内对发病率的估计不准确、报告不明确，而且很可能诊断不足。本研究旨在通过数据标准化，就 ORNJ 及相关前兆状态的明确定义和表型达成共识，以促进 ORNJ 的有效诊断、监测和多学科管理。
{"title":"International Expert-Based Consensus Definition, Staging Criteria, and Minimum Data Elements for Osteoradionecrosis of the Jaw: An Inter-Disciplinary Modified Delphi Study","authors":"The International ORAL Consortium, Amy C. Moreno, Erin E. Watson, Laia Humbert-Vidan, Douglas E. Peterson, Lisanne V van Dijk, Teresa Guerrero Urbano, Lisa Van den Bosch, Andrew J. Hope, Matthew S. Katz, Frank J.P. Hoebers, Ruth A. Aponte Wesson, James E. Bates, Paolo Bossi, Adeyinka F. Dayo, Mélanie Doré, Eduardo Rodrigues Fregnani, Thomas J. Galloway, Daphna Y. Gelblum, Issa A. Hanna, Christina E. Henson, Sudarat Kiat-amnuay, Anke Korfage, Nancy Y. Lee, Carol M. Lewis, Charlotte Duch Lynggaard, Antti A. Mäkitie, Marco Magalhaes, Yvonne M. Mowery, Carles Muñoz-Montplet, Jeffrey N. Myers, Ester Orlandi, Jaymit Patel, Jillian M. Rigert, Deborah Saunders, Jonathan D. Schoenfeld, Ugur Selek, Efsun Somay, Vinita Takiar, Juliette Thariat, Gerda M. Verduijn, Alessandro Villa, Nick West, Max J.H. Witjes, Alex Won, Mark E. Wong, Christopher M.K.L. Yao, Simon W. Young, Kamal Al-eryani, Carly E.A. Barbon, Doke J.M. Buurman, François J. Dieleman, Theresa M. Hofstede, Abdul Ahad Khan, Adegbenga O. Otun, John C. Robinson, Lauren Hum, Jorgen Johansen, Rajesh Lalla, Alexander Lin, Vinod Patel, Richard J. Shaw, Mark S. Chambers, Daniel Ma, Mabi Singh, Noam Yarom, Abdallah Sherif Radwan Mohamed, Katherine A. Hutcheson, Stephen Y. Lai, Clifton David Fuller","doi":"10.1101/2024.04.07.24305400","DOIUrl":"https://doi.org/10.1101/2024.04.07.24305400","url":null,"abstract":"<strong>Purpose</strong> Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to the head and neck. With over 9 published definitions and at least 16 diagnostic/staging systems, the true incidence and severity of ORNJ are obscured by lack of a standard for disease definition and severity assessment, leading to inaccurate estimation of incidence, reporting ambiguity, and likely under-diagnosis worldwide. This study aimed to achieve consensus on an explicit definition and phenotype of ORNJ and related precursor states through data standardization to facilitate effective diagnosis, monitoring, and multidisciplinary management of ORNJ.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140590584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.1101/2024.03.26.24304906
Robert J Schroth, Sukeerat Bajwa, Victor H K Lee, Betty-Anne Mittermuller, Sarbjeet Singh, Vivianne Cruz de Jesus, Mary Bertone, Prashen Chelikani
Background: Non-surgical interventions are preferred to address the widespread issue of early childhood caries (ECC). Silver diamine fluoride (SDF) is an antimicrobial agent and alternative treatment option that can be used to arrest dental decay. While there is optimism with SDF with regard to caries management, there is no true consensus on the number and frequency of applications for children. The purpose of this study was to examine the effectiveness of 38% SDF to arrest ECC at three different application regimen intervals. Methods: Children with ECC were recruited from community dental clinics into an open-label, parallel-group, randomized clinical trial. Participants were randomized to one of three groups: visits one month, four months, or six months apart. Participants received applications of 38% SDF, along with 5% sodium fluoride varnish (NaFV), at the first two visits to treat cavitated carious lesions. Lesions were followed and arrest rates were calculated. Lesions were considered arrested if they were hard on probing and black in colour. Statistics included descriptive and bivariate analyses. A p-value of ≤ 0.05 was considered significant. Results: Eighty-four children participated in the study (49 males and 35 females, mean age: 44.4 ± 14.2 months). Treatment groups were well matched with 28 participants per group. A total of 374 teeth and 505 lesions were followed. Posterior lesions represented only 29.1% of affected surfaces. Almost all SDF treated lesions were arrested for the one-month (98%) and four-month (95.8%) interval groups at the final visit. The six-month group experienced the lowest arrest rates; only 72% of lesions were arrested (p < 0.001). The duration of application intervals was inversely associated with improvements in arrest rates for all lesions.
{"title":"An open-label, parallel-group, randomized clinical trial of different silver diamine fluoride application intervals to arrest dental caries","authors":"Robert J Schroth, Sukeerat Bajwa, Victor H K Lee, Betty-Anne Mittermuller, Sarbjeet Singh, Vivianne Cruz de Jesus, Mary Bertone, Prashen Chelikani","doi":"10.1101/2024.03.26.24304906","DOIUrl":"https://doi.org/10.1101/2024.03.26.24304906","url":null,"abstract":"Background: Non-surgical interventions are preferred to address the widespread issue of early childhood caries (ECC). Silver diamine fluoride (SDF) is an antimicrobial agent and alternative treatment option that can be used to arrest dental decay. While there is optimism with SDF with regard to caries management, there is no true consensus on the number and frequency of applications for children. The purpose of this study was to examine the effectiveness of 38% SDF to arrest ECC at three different application regimen intervals.\u0000Methods: Children with ECC were recruited from community dental clinics into an open-label, parallel-group, randomized clinical trial. Participants were randomized to one of three groups: visits one month, four months, or six months apart. Participants received applications of 38% SDF, along with 5% sodium fluoride varnish (NaFV), at the first two visits to treat cavitated carious lesions. Lesions were followed and arrest rates were calculated. Lesions were considered arrested if they were hard on probing and black in colour. Statistics included descriptive and bivariate analyses. A <em>p</em>-value of ≤ 0.05 was considered significant.\u0000Results: Eighty-four children participated in the study (49 males and 35 females, mean age: 44.4 ± 14.2 months). Treatment groups were well matched with 28 participants per group. A total of 374 teeth and 505 lesions were followed. Posterior lesions represented only 29.1% of affected surfaces. Almost all SDF treated lesions were arrested for the one-month (98%) and four-month (95.8%) interval groups at the final visit. The six-month group experienced the lowest arrest rates; only 72% of lesions were arrested (<em>p</em> < 0.001). The duration of application intervals was inversely associated with improvements in arrest rates for all lesions.","PeriodicalId":501363,"journal":{"name":"medRxiv - Dentistry and Oral Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140315316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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