Journal of Clinical Densitometry最新文献_第9页

Changes in lean mass and fat mass in children with Osteogenesis Imperfecta 成骨不全症患儿瘦脂肪量的变化

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-04 DOI: 10.1016/j.jocd.2025.101605

Holly Wright , Sze Choong Wong , Misha Gilani , Helen McDevitt , Sheila Shepherd , Avril Mason

Background: Deficits in skeletal muscle and function, with resultant abnormal body composition, is a recognised feature of Osteogenesis Imperfecta (OI). Less is known about longitudinal change in body composition in OI. Our objective was to perform a retrospective analysis of longitudinal change in body composition (lean mass and fat mass) in children with OI.

Methodology: Data was collected from 29 children, with a diagnosis of OI, who had at least two dual-energy x-ray absorptiometry (DXA) scans performed between 2015 and 2022. Assessed variables of height, body mass index (BMI), lean mass index (LMI) and fat mass index (FMI), were converted to z scores. Results were reported as median (range).

Results: Median age at baseline and follow-up were 10.7 and 14.2 years, respectively. Median height z-score at baseline was -1.10, which was significantly lower than a control population (p<0.001). Median height z-score at latest follow-up was -0.80, which was not significantly different from baseline (p=0.870). Median BMI z-score at baseline was 0.15, which was not significantly different than a control population (p=0.804). Median BMI z-score at latest follow-up was 0.02, which was not significantly different from baseline (p=0.730). At baseline, median LMI z-score was -2.43, which was significantly lower than a control population (p<0.001). Median LMI z-score at follow-up was -1.78, which was not significantly different from baseline (p=0.080). At baseline, median FMI z-score was 0.57 which was significantly higher than a control population (p=0.001). Median FMI z-score at follow-up was 0.62, which was not significantly different from baseline (p=0.540).

Conclusion: Children with OI have abnormal body composition throughout childhood typically with low lean mass and relatively high fat mass. These abnormalities in body composition do not change with follow-up. Strategies to improve lean mass, including physical or medical therapies, should be explored in OI given the close relationship between muscle and bone.

背景：骨骼肌和功能缺陷，以及由此导致的身体成分异常，是成骨不全症（OI）的一个公认特征。对于成骨不全患者体内成分的纵向变化了解较少。我们的目的是对成骨不全儿童身体组成（瘦质量和脂肪质量）的纵向变化进行回顾性分析。方法：收集29名诊断为成骨不全的儿童的数据，这些儿童在2015年至2022年期间至少进行了两次双能x线吸收仪（DXA）扫描。评估变量身高、身体质量指数（BMI）、瘦质量指数（LMI）和脂肪质量指数（FMI）转换为z分数。结果以中位数（范围）报告。结果：基线和随访时的中位年龄分别为10.7岁和14.2岁。基线时身高z得分中位数为-1.10，显著低于对照人群（p<0.001）。最新随访中位身高z得分为-0.80，与基线无显著差异（p=0.870）。基线时BMI z评分中位数为0.15，与对照组相比差异无统计学意义（p=0.804）。最新随访时BMI z评分中位数为0.02，与基线无显著差异（p=0.730）。基线时，LMI z-score中位数为-2.43，显著低于对照组（p<0.001）。随访时LMI z-score中位数为-1.78，与基线无显著差异（p=0.080）。基线时，FMI z-score中位数为0.57，显著高于对照组（p=0.001）。随访时FMI z-score中位数为0.62，与基线无显著差异（p=0.540）。结论：成骨不全儿童在整个儿童期均存在身体成分异常，典型表现为低瘦体质量和相对高脂体质量。这些身体成分的异常不随随访而改变。考虑到肌肉和骨骼之间的密切关系，在成骨不全症中应该探索改善瘦质量的策略，包括物理或药物治疗。

{"title":"Changes in lean mass and fat mass in children with Osteogenesis Imperfecta","authors":"Holly Wright , Sze Choong Wong , Misha Gilani , Helen McDevitt , Sheila Shepherd , Avril Mason","doi":"10.1016/j.jocd.2025.101605","DOIUrl":"10.1016/j.jocd.2025.101605","url":null,"abstract":"<div><div><em>Background:</em> Deficits in skeletal muscle and function, with resultant abnormal body composition, is a recognised feature of Osteogenesis Imperfecta (OI). Less is known about longitudinal change in body composition in OI. Our objective was to perform a retrospective analysis of longitudinal change in body composition (lean mass and fat mass) in children with OI.</div><div><em>Methodology:</em> Data was collected from 29 children, with a diagnosis of OI, who had at least two dual-energy x-ray absorptiometry (DXA) scans performed between 2015 and 2022. Assessed variables of height, body mass index (BMI), lean mass index (LMI) and fat mass index (FMI), were converted to z scores. Results were reported as median (range).</div><div><em>Results:</em> Median age at baseline and follow-up were 10.7 and 14.2 years, respectively. Median height z-score at baseline was -1.10, which was significantly lower than a control population (p<0.001). Median height z-score at latest follow-up was -0.80, which was not significantly different from baseline (p=0.870). Median BMI z-score at baseline was 0.15, which was not significantly different than a control population (p=0.804). Median BMI z-score at latest follow-up was 0.02, which was not significantly different from baseline (p=0.730). At baseline, median LMI z-score was -2.43, which was significantly lower than a control population (p<0.001). Median LMI z-score at follow-up was -1.78, which was not significantly different from baseline (p=0.080). At baseline, median FMI z-score was 0.57 which was significantly higher than a control population (p=0.001). Median FMI z-score at follow-up was 0.62, which was not significantly different from baseline (p=0.540).</div><div><em>Conclusion:</em> Children with OI have abnormal body composition throughout childhood typically with low lean mass and relatively high fat mass. These abnormalities in body composition do not change with follow-up. Strategies to improve lean mass, including physical or medical therapies, should be explored in OI given the close relationship between muscle and bone.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 4","pages":"Article 101605"},"PeriodicalIF":1.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Radiation Therapy on CT Attenuation of Bone in Patients with Anorectal Cancer Treated with Chemotherapy 放疗对化疗肛肠癌患者骨CT衰减的影响

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 DOI: 10.1016/j.jocd.2025.101597

Gary K. Schneider , Jason A. Benedict , Jennifer Matsui , Gavin Wu , Michael Ruesch , Rahul Prasad , Pannaga Malalur , Vedat Yildiz , Eric Miller , Steven W. Ing

Radiation therapy (RT), a standard treatment modality for locally advanced anorectal cancer, may be followed by pelvic fractures, but there are currently no formal recommendations to evaluate bone health prior to RT. Recent studies have demonstrated CT attenuation measurement of lumbar vertebrae as a surrogate marker of bone mineral density (BMD). In this single-institution retrospective cohort analysis of patients with anorectal carcinoma treated with RT, we assess lumbar and sacral CT attenuation before and after RT. CT scans of 302 patients with at least one pre- and post- RT CT scan including all of L1, L3, L5, and sacrum were reviewed, and CT attenuation measured at each level. All CT scans were obtained for either cancer surveillance or other medically indicated reason. CT attenuation measurements were adjusted for presence of IV contrast and nonstandard CT tube voltage. Prior to RT, mean bone attenuation at L1, L3, L5, and sacrum were 158.4, 151.1, 157.8, and 231.0 HU respectively. Three months post-RT, L1 and L3 had mean differences of +1.7 (+1.1 %) and −7.7 (−5.1 %) HU, respectively, while L5 and sacrum had mean differences of −48.8 (−31.0 %) and −65.9 (−28.6 %) HU, respectively. There was little to no evidence of further decrease at any vertebral level beyond three months after RT, nor was there evidence for increase in HU beyond three months, by which time RT courses were completed. This suggests that bone loss from RT is associated with proximity to the radiation field and the majority of the observed decline occurs within the first three months following the start of RT.

放射治疗（RT）是局部晚期肛管直肠癌的标准治疗方式，可能会在盆腔骨折之后进行，但目前没有正式的建议在放疗之前评估骨骼健康。最近的研究表明，腰椎CT衰减测量可以作为骨矿物质密度（BMD）的替代指标。在这项单机构回顾性队列分析中，我们评估了接受RT治疗的肛肠癌患者在RT前后的腰椎和骶骨CT衰减。我们回顾了302例患者的CT扫描，这些患者至少进行了一次RT前后的CT扫描，包括L1、L3、L5和骶骨，并测量了每个级别的CT衰减。所有的CT扫描都是为了癌症监测或其他医学上的原因。根据静脉造影剂和非标准CT管电压的存在调整CT衰减测量。放疗前，L1、L3、L5和骶骨的平均骨衰减分别为158.4、151.1、157.8和231.0 HU。术后3个月，L1和L3的平均差异分别为+1.7（+1.1 %）和- 7.7(- 5.1 %)HU， L5和骶骨的平均差异分别为- 48.8（- 31.0 %）和- 65.9(- 28.6 %)HU。在放疗后3个月后，几乎没有证据表明任何椎体水平进一步下降，也没有证据表明3个月后HU增加，到那时放疗课程完成。这表明放射治疗导致的骨质流失与靠近放射场有关，大部分观察到的骨质流失发生在放射治疗开始后的前三个月内。

{"title":"Effect of Radiation Therapy on CT Attenuation of Bone in Patients with Anorectal Cancer Treated with Chemotherapy","authors":"Gary K. Schneider , Jason A. Benedict , Jennifer Matsui , Gavin Wu , Michael Ruesch , Rahul Prasad , Pannaga Malalur , Vedat Yildiz , Eric Miller , Steven W. Ing","doi":"10.1016/j.jocd.2025.101597","DOIUrl":"10.1016/j.jocd.2025.101597","url":null,"abstract":"<div><div>Radiation therapy (RT), a standard treatment modality for locally advanced anorectal cancer, may be followed by pelvic fractures, but there are currently no formal recommendations to evaluate bone health prior to RT. Recent studies have demonstrated CT attenuation measurement of lumbar vertebrae as a surrogate marker of bone mineral density (BMD). In this single-institution retrospective cohort analysis of patients with anorectal carcinoma treated with RT, we assess lumbar and sacral CT attenuation before and after RT. CT scans of 302 patients with at least one pre- and post- RT CT scan including all of L1, L3, L5, and sacrum were reviewed, and CT attenuation measured at each level. All CT scans were obtained for either cancer surveillance or other medically indicated reason. CT attenuation measurements were adjusted for presence of IV contrast and nonstandard CT tube voltage. Prior to RT, mean bone attenuation at L1, L3, L5, and sacrum were 158.4, 151.1, 157.8, and 231.0 HU respectively. Three months post-RT, L1 and L3 had mean differences of +1.7 (+1.1 %) and −7.7 (−5.1 %) HU, respectively, while L5 and sacrum had mean differences of −48.8 (−31.0 %) and −65.9 (−28.6 %) HU, respectively. There was little to no evidence of further decrease at any vertebral level beyond three months after RT, nor was there evidence for increase in HU beyond three months, by which time RT courses were completed. This suggests that bone loss from RT is associated with proximity to the radiation field and the majority of the observed decline occurs within the first three months following the start of RT.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 3","pages":"Article 101597"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toe Grip Strength is Another Indicator of Muscle Strength and Bone Mass in Older Men 脚趾握力是老年男性肌肉力量和骨量的另一个指标

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-06-24 DOI: 10.1016/j.jocd.2025.101603

Elie Maliha , Christophe Jacob , Nour Khalil , Abdel-Jalil Berro , Rami Abboud , Rawad ElHage

Toe grip strength (TGS) measures foot muscle strength and evaluates stability maintenance, as well as the risk of falls. Handgrip strength (HGS) is considered a simple and effective method for assessing overall strength, and it correlates with bone variables. The aim of this study was: first, to investigate the relationship between TGS and overall strength and bone variables; and second, to compare the relationships between TGS and HGS with overall strength and bone variables. This cross-sectional study included 59 Caucasian men aged 60 to 84 years. Participants underwent muscle strength testing using exercises such as the bench press, leg extension, leg curl, and biceps curl, along with assessments of HGS and TGS. Body composition and bone mineral density (BMD) were assessed using dual-energy X-ray absorptiometry (DXA). TGS was positively correlated with bench press performance (r = 0.68; p < 0.001), leg extension strength (r = 0.72; p < 0.001), leg curl strength (r = 0.83; p < 0.001), and biceps curl strength (r = 0.74; p < 0.001). A strong positive correlation was also observed between TGS and HGS (r = 0.88; p < 0.001). Finally, both TGS and HGS showed significant positive correlations with bone mass (r = 0.62; p < 0.001 and r = 0.68; p < 0.001, for toe grip and handgrip respectively). In conclusion, this study suggests that TGS is as good as HGS as a positive determinant of muscle strength and bone mass in older men.

脚趾握力（TGS）测量足部肌肉力量，评估稳定性维持，以及跌倒的风险。握力（HGS）被认为是评估整体力量的一种简单有效的方法，它与骨骼变量相关。本研究的目的是：首先，探讨TGS与整体强度和骨骼变量之间的关系；第二，比较TGS和HGS与整体强度和骨骼变量之间的关系。这项横断面研究包括59名年龄在60至84岁之间的高加索男性。参与者通过卧推、腿部伸展、腿部弯曲和肱二头肌弯曲等锻炼进行肌肉力量测试，同时评估HGS和TGS。采用双能x线吸收仪（DXA）评估体成分和骨密度（BMD）。TGS与卧推性能呈正相关(r = 0.68；P <； 0.001)，腿部伸展力量(r = 0.72；P <； 0.001)，腿屈强度(r = 0.83；P <； 0.001)，二头肌弯曲强度(r = 0.74；p & lt; 0.001)。TGS与HGS之间也存在显著正相关(r = 0.88；p & lt; 0.001)。最后，TGS和HGS与骨量呈显著正相关(r = 0.62；P <； 0.001,r = 0.68；P <； 0.001，分别为趾握和手握)。总之，这项研究表明，TGS和HGS一样，是老年男性肌肉力量和骨量的积极决定因素。

{"title":"Toe Grip Strength is Another Indicator of Muscle Strength and Bone Mass in Older Men","authors":"Elie Maliha , Christophe Jacob , Nour Khalil , Abdel-Jalil Berro , Rami Abboud , Rawad ElHage","doi":"10.1016/j.jocd.2025.101603","DOIUrl":"10.1016/j.jocd.2025.101603","url":null,"abstract":"<div><div>Toe grip strength (TGS) measures foot muscle strength and evaluates stability maintenance, as well as the risk of falls. Handgrip strength (HGS) is considered a simple and effective method for assessing overall strength, and it correlates with bone variables. The aim of this study was: first, to investigate the relationship between TGS and overall strength and bone variables; and second, to compare the relationships between TGS and HGS with overall strength and bone variables. This cross-sectional study included 59 Caucasian men aged 60 to 84 years. Participants underwent muscle strength testing using exercises such as the bench press, leg extension, leg curl, and biceps curl, along with assessments of HGS and TGS. Body composition and bone mineral density (BMD) were assessed using dual-energy X-ray absorptiometry (DXA). TGS was positively correlated with bench press performance (<em>r</em> = 0.68; <em>p</em> < 0.001), leg extension strength (<em>r</em> = 0.72; <em>p</em> < 0.001), leg curl strength (<em>r</em> = 0.83; <em>p</em> < 0.001), and biceps curl strength (<em>r</em> = 0.74; <em>p</em> < 0.001). A strong positive correlation was also observed between TGS and HGS (<em>r</em> = 0.88; <em>p</em> < 0.001). Finally, both TGS and HGS showed significant positive correlations with bone mass (<em>r</em> = 0.62; <em>p</em> < 0.001 and <em>r</em> = 0.68; <em>p</em> < 0.001, for toe grip and handgrip respectively). In conclusion, this study suggests that TGS is as good as HGS as a positive determinant of muscle strength and bone mass in older men.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 4","pages":"Article 101603"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone health ECHO case report: Normocalcemic hyperparathyroidism in a patient with osteoporosis referred for pre-operative bone health evaluation before spine surgery 骨健康ECHO病例报告：骨质疏松症患者的正常钙血症甲状旁腺功能亢进在脊柱手术前进行术前骨健康评估

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-06-16 DOI: 10.1016/j.jocd.2025.101600

Danielle D’Annibale , E. Michael Lewiecki , Gina Woods

Primary hyperparathyroidism can be divided into three clinical phenotypes: classical primary hyperparathyroidism with hypercalcemia and target organ involvement, asymptomatic primary hyperparathyroidism with hypercalcemia, and normocalcemic primary hyperparathyroidism. The latter phenotype is being increasingly recognized in patients having serum parathyroid hormone levels measured as part of the initial evaluation of osteoporosis. The diagnosis of normocalcemic primary hyperparathyroidism requires exclusion of secondary causes of parathyroid hormone elevation, such an vitamin D deficiency and calcium malabsorption. There is no consensus on the management of patients with normocalcemic primary hyperparathyroidism, particularly with regard to consideration of parathyroid surgery versus clinical observation. This is a case report of a patient with persistently normal calcium levels, high parathyroid hormone, and no recognized cause of secondary hyperparathyroidism. This case was presented and discussed at Bone Health Extension for Community Healthcare Outcomes, a virtual community of practice that has been meeting online weekly since 2015.

原发性甲状旁腺功能亢进可分为三种临床表型：典型原发性甲状旁腺功能亢进伴高钙血症及累及靶器官、无症状原发性甲状旁腺功能亢进伴高钙血症和正常血钙血症原发性甲状旁腺功能亢进。作为骨质疏松症初步评估的一部分，测量血清甲状旁腺激素水平的患者越来越多地认识到后一种表型。正常血钙水平原发性甲状旁腺功能亢进的诊断需要排除甲状旁腺激素升高的继发原因，如维生素D缺乏和钙吸收不良。对于正常血钙水平的原发性甲状旁腺功能亢进患者的治疗，特别是甲状旁腺手术与临床观察的比较，目前尚无共识。这是一个病例报告的病人持续正常的钙水平，高甲状旁腺激素，继发性甲状旁腺功能亢进没有明确的原因。该病例在骨骼健康扩展社区医疗保健结果上进行了介绍和讨论，这是一个自2015年以来每周在线会议的虚拟实践社区。

{"title":"Bone health ECHO case report: Normocalcemic hyperparathyroidism in a patient with osteoporosis referred for pre-operative bone health evaluation before spine surgery","authors":"Danielle D’Annibale , E. Michael Lewiecki , Gina Woods","doi":"10.1016/j.jocd.2025.101600","DOIUrl":"10.1016/j.jocd.2025.101600","url":null,"abstract":"<div><div>Primary hyperparathyroidism can be divided into three clinical phenotypes: classical primary hyperparathyroidism with hypercalcemia and target organ involvement, asymptomatic primary hyperparathyroidism with hypercalcemia, and normocalcemic primary hyperparathyroidism. The latter phenotype is being increasingly recognized in patients having serum parathyroid hormone levels measured as part of the initial evaluation of osteoporosis. The diagnosis of normocalcemic primary hyperparathyroidism requires exclusion of secondary causes of parathyroid hormone elevation, such an vitamin D deficiency and calcium malabsorption. There is no consensus on the management of patients with normocalcemic primary hyperparathyroidism, particularly with regard to consideration of parathyroid surgery versus clinical observation. This is a case report of a patient with persistently normal calcium levels, high parathyroid hormone, and no recognized cause of secondary hyperparathyroidism. This case was presented and discussed at Bone Health Extension for Community Healthcare Outcomes, a virtual community of practice that has been meeting online weekly since 2015.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 4","pages":"Article 101600"},"PeriodicalIF":1.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor: Persisting lymphangiogram contrast, A potential DXA confounder 致编辑的信：持续的淋巴管造影，潜在的DXA混淆

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-06-16 DOI: 10.1016/j.jocd.2025.101601

N. Binkley, A. Eastman, N. Jina, D. Krueger

引用次数: 0

Trabecular Bone Score in Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis 2型糖尿病的骨小梁评分：最新的系统回顾和荟萃分析

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-06-10 DOI: 10.1016/j.jocd.2025.101602

A.B.M. Kamrul-Hasan , Saptarshi Bhattacharya , Vanishri Ganakumar , Lakshmi Nagendra , Deep Dutta , Fatema Tuz Zahura Aalpona , Joseph M. Pappachan

Background: Trabecular bone score (TBS) independently predicts diabetic bone disease. Many studies have compared TBS in those with and without diabetes, showing inconsistent results. We conducted a systematic review and meta-analysis to evaluate TBS in type 2 diabetes mellitus (T2DM) and clarify its role, considering gender and other confounders.

Methodology: Relevant studies were systematically searched until October 2024 using related terms across multiple databases. RevMan Web and R software were employed to conduct statistical analyses. Meta-analyses utilized random-effects models and the inverse variance statistical method; results were expressed as mean differences (MD) with 95 % confidence intervals. The primary outcome of interest was the MD in TBS (unadjusted or adjusted) between the T2DM and non-diabetes groups.

Results: Data from 27 studies with 16,354 subjects were analyzed. Compared to controls without diabetes, subjects with T2DM exhibited lower unadjusted TBS in the combined sex group (MD -0.10 [-0.18, -0.02], P = 0.01), as well as in men (MD -0.02 [-0.04, -0.00], P = 0.02) and women (MD -0.05 [-0.07, -0.03], P < 0.0001). Individuals with T2DM also had a lower adjusted TBS in the combined sex group (MD -0.16 [-0.24, -0.08], P < 0.0001), men (MD -0.02 [-0.04, -0.00], P = 0.02), and women (MD -0.04 [-0.06, -0.02], P = 0.0005). While lumbar spine bone mineral density (BMD) was higher in individuals with T2DM than in those without across all three groups, total hip BMD was higher in women and the combined sex group; femoral neck BMD was higher only in the combined sex group.

Conclusion: According to the data analyzed in this updated meta-analysis, T2DM appears to adversely affect TBS, despite having a positive effect on BMD; however, the evidence level is very low. Larger and longer-term studies are necessary to explore the implicated factors and potential remedial strategies.

PROSPERO registration number: CRD42024608004

背景：骨小梁评分（TBS）可独立预测糖尿病骨病。许多研究比较了糖尿病患者和非糖尿病患者的TBS，结果不一致。在考虑性别和其他混杂因素的情况下，我们进行了一项系统回顾和荟萃分析，以评估2型糖尿病（T2DM）患者的TBS，并阐明其作用。方法：系统检索相关研究，直到2024年10月，使用多个数据库的相关术语。采用RevMan Web和R软件进行统计分析。meta分析采用随机效应模型和反方差统计方法；结果表示为平均差异（MD），置信区间为95% %。研究的主要终点是T2DM组和非糖尿病组之间TBS的MD（未调整或调整）。结果：分析了27项研究的16,354名受试者的数据。与未患糖尿病的对照组相比，T2DM患者在性别组合组中表现出较低的未调整TBS (MD -0.10 [-0.18, -0.02], P = 0.01)，男性（MD -0.02 [-0.04, -0.00], P = 0.02）和女性（MD -0.05 [-0.07, -0.03], P <； 0.0001）。T2DM患者的调整TBS在性别组合组中也较低（MD -0.16 [-0.24, -0.08], P <； 0.0001），男性（MD -0.02 [-0.04, -0.00], P = 0.02），女性（MD -0.04 [-0.06, -0.02], P = 0.0005）。在所有三组中，T2DM患者的腰椎骨密度（BMD）均高于非T2DM患者，但女性和两性混合组的髋部骨密度（BMD）较高；股骨颈骨密度仅在性别混合组较高。结论：根据这项最新荟萃分析分析的数据，T2DM似乎对TBS有不利影响，尽管对BMD有积极影响；然而，证据水平非常低。有必要进行更大规模和更长期的研究，以探索涉及的因素和潜在的补救策略。普洛斯彼罗注册号：CRD42024608004

{"title":"Trabecular Bone Score in Type 2 Diabetes Mellitus: An Updated Systematic Review and Meta-Analysis","authors":"A.B.M. Kamrul-Hasan , Saptarshi Bhattacharya , Vanishri Ganakumar , Lakshmi Nagendra , Deep Dutta , Fatema Tuz Zahura Aalpona , Joseph M. Pappachan","doi":"10.1016/j.jocd.2025.101602","DOIUrl":"10.1016/j.jocd.2025.101602","url":null,"abstract":"<div><div><em>Background:</em> Trabecular bone score (TBS) independently predicts diabetic bone disease. Many studies have compared TBS in those with and without diabetes, showing inconsistent results. We conducted a systematic review and meta-analysis to evaluate TBS in type 2 diabetes mellitus (T2DM) and clarify its role, considering gender and other confounders.</div><div><em>Methodology:</em> Relevant studies were systematically searched until October 2024 using related terms across multiple databases. RevMan Web and R software were employed to conduct statistical analyses. Meta-analyses utilized random-effects models and the inverse variance statistical method; results were expressed as mean differences (MD) with 95 % confidence intervals. The primary outcome of interest was the MD in TBS (unadjusted or adjusted) between the T2DM and non-diabetes groups.</div><div><em>Results:</em> Data from 27 studies with 16,354 subjects were analyzed. Compared to controls without diabetes, subjects with T2DM exhibited lower unadjusted TBS in the combined sex group (MD -0.10 [-0.18, -0.02], <em>P</em> = 0.01), as well as in men (MD -0.02 [-0.04, -0.00], <em>P</em> = 0.02) and women (MD -0.05 [-0.07, -0.03], <em>P</em> < 0.0001). Individuals with T2DM also had a lower adjusted TBS in the combined sex group (MD -0.16 [-0.24, -0.08], <em>P</em> < 0.0001), men (MD -0.02 [-0.04, -0.00], <em>P</em> = 0.02), and women (MD -0.04 [-0.06, -0.02], <em>P</em> = 0.0005). While lumbar spine bone mineral density (BMD) was higher in individuals with T2DM than in those without across all three groups, total hip BMD was higher in women and the combined sex group; femoral neck BMD was higher only in the combined sex group.</div><div><em>Conclusion:</em> According to the data analyzed in this updated meta-analysis, T2DM appears to adversely affect TBS, despite having a positive effect on BMD; however, the evidence level is very low. Larger and longer-term studies are necessary to explore the implicated factors and potential remedial strategies.</div><div><em>PROSPERO registration number:</em> CRD42024608004</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 4","pages":"Article 101602"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DXA-Measured Visceral Adipose Tissue and Incident Cardiovascular Disease Events in Middle-Aged Adults: Busselton Healthy Ageing Study dxa测量的中年人内脏脂肪组织和心血管疾病事件：Busselton健康老龄化研究

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-06-10 DOI: 10.1016/j.jocd.2025.101599

Kun Zhu , Michael Hunter , Chrianna Bharat , Kevin Murray , Jennie Hui , John P. Walsh , Joseph Hung

Background: DXA-measured visceral adipose tissue (VAT) is associated with development of metabolic syndrome in middle-aged adults, but its association with incident cardiovascular disease (CVD) has not been studied. We evaluated the longitudinal association of baseline VAT_DXA with incident CVD events within the Busselton Healthy Ageing study.

Methods: Participants (n = 4866, 54 % female, aged 46-70 years, ∼99 % white) were assessed for VAT_DXA and were followed up longitudinally for a median of 7.9 years. Outcome measures were time to incident CVD or coronary heart disease (CHD) events (defined as non-fatal hospitalisations or death). Sex-stratified associations were examined using Cox proportional hazards models adjusting for baseline age, lifestyle factors and prior CVD.

Results: Mean baseline VAT_DXA mass was 1678±877 g and 882±600 g in males and females respectively. Incident CVD and CHD events were recorded for 332 (6.8 %) and 245 (5.0 %) study participants. There was a near-linear increase in risk for CVD and CHD events with VAT_DXA in both sexes. After covariate adjustment each standard deviation (SD) increment in VAT_DXA was associated with a hazard ratio [95 % confidence interval] for incident CVD in males and females of 1.26 [1.11-1.44] and 1.30 [1.10-1.55] respectively, and a hazard ratio for CHD of 1.28 [1.11-1.49] and 1.40 [1.14-1.72] respectively. However, VAT_DXA was no longer independently associated with CVD events once adjusted for BMI and waist circumference.

Conclusion: VAT_DXA has utility for identifying middle-aged adults at greater risk for incident CVD and CHD but further studies are needed to determine if VAT_DXA can improve risk discrimination beyond anthropometric measures.

背景：dxa测量的内脏脂肪组织（VAT）与中年人代谢综合征的发展有关，但其与心血管疾病（CVD）发病率的关系尚未研究。在Busselton健康老龄化研究中，我们评估了基线VATDXA与心血管疾病事件的纵向关联。方法：对参与者（n = 4866，女性54 %，年龄46-70岁，白人99 %）进行VATDXA评估，纵向随访中位数为7.9年。结果测量是发生心血管疾病或冠心病（CHD）事件的时间（定义为非致命性住院或死亡）。使用Cox比例风险模型对基线年龄、生活方式因素和既往心血管疾病进行校正，以检验性别分层的相关性。结果：男性和女性的VATDXA平均基线质量分别为1678±877 g和882±600 g。记录了332名（6.8 %）和245名（5.0 %）研究参与者的心血管疾病和冠心病事件。VATDXA患者的CVD和CHD事件的风险在两性中均呈近线性增加。协变量调整后，VATDXA的每个标准差（SD）增量与男性和女性心血管事件的风险比[95 %置信区间]分别为1.26[1.11-1.44]和1.30[1.10-1.55]，冠心病的风险比分别为1.28[1.11-1.49]和1.40[1.14-1.72]。然而，一旦调整BMI和腰围，VATDXA不再与CVD事件独立相关。结论：VATDXA可用于识别心血管疾病和冠心病发生风险较高的中年人，但需要进一步的研究来确定VATDXA是否可以改善人体测量测量之外的风险识别。

{"title":"DXA-Measured Visceral Adipose Tissue and Incident Cardiovascular Disease Events in Middle-Aged Adults: Busselton Healthy Ageing Study","authors":"Kun Zhu , Michael Hunter , Chrianna Bharat , Kevin Murray , Jennie Hui , John P. Walsh , Joseph Hung","doi":"10.1016/j.jocd.2025.101599","DOIUrl":"10.1016/j.jocd.2025.101599","url":null,"abstract":"<div><div><em>Background:</em> DXA-measured visceral adipose tissue (VAT) is associated with development of metabolic syndrome in middle-aged adults, but its association with incident cardiovascular disease (CVD) has not been studied. We evaluated the longitudinal association of baseline VAT<sub>DXA</sub> with incident CVD events within the Busselton Healthy Ageing study.</div><div><em>Methods:</em> Participants (<em>n</em> = 4866, 54 % female, aged 46-70 years, ∼99 % white) were assessed for VAT<sub>DXA</sub> and were followed up longitudinally for a median of 7.9 years. Outcome measures were time to incident CVD or coronary heart disease (CHD) events (defined as non-fatal hospitalisations or death). Sex-stratified associations were examined using Cox proportional hazards models adjusting for baseline age, lifestyle factors and prior CVD.</div><div><em>Results:</em> Mean baseline VAT<sub>DXA</sub> mass was 1678±877 g and 882±600 g in males and females respectively. Incident CVD and CHD events were recorded for 332 (6.8 %) and 245 (5.0 %) study participants. There was a near-linear increase in risk for CVD and CHD events with VAT<sub>DXA</sub> in both sexes. After covariate adjustment each standard deviation (SD) increment in VAT<sub>DXA</sub> was associated with a hazard ratio [95 % confidence interval] for incident CVD in males and females of 1.26 [1.11-1.44] and 1.30 [1.10-1.55] respectively, and a hazard ratio for CHD of 1.28 [1.11-1.49] and 1.40 [1.14-1.72] respectively. However, VAT<sub>DXA</sub> was no longer independently associated with CVD events once adjusted for BMI and waist circumference.</div><div><em>Conclusion:</em> VAT<sub>DXA</sub> has utility for identifying middle-aged adults at greater risk for incident CVD and CHD but further studies are needed to determine if VAT<sub>DXA</sub> can improve risk discrimination beyond anthropometric measures.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 3","pages":"Article 101599"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Mineral Density and Associated Factors in Individuals with Traumatic Unilateral Transfemoral Amputation 外伤性单侧经股截肢患者的骨密度及其相关因素

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-06-03 DOI: 10.1016/j.jocd.2025.101598

Gizem Kılınç Kamacı, Merve Örücü Atar, Elif Tekin, Fatma Özcan, Yasin Demir, Koray Aydemir

Introduction/background: Lower extremity amputations, particularly at more proximal levels such as transfemoral amputations (TFA)s, negatively affect bone mineral density (BMD). The aim of this study was to determine the relationship between muscle strength, residual limb length (RLL), and BMD on the amputated side in individuals with traumatic unilateral TFA and to investigate other potentially related factors.

Methodology: This is a retrospective, cross-sectional study. The study included 39 individuals with TFA. Demographic and clinical data of the individuals were recorded. RLL was determined by measuring the distance from the trochanter major to the most distal end point of the stump. Hip flexor and extensor muscle strengths were assessed by determining peak torque at an angular velocity of 60°/s using an isokinetic system. Dual-energy X-ray absorptiometry (DXA) imaging T-scores of the femoral neck and lumbar spine on the amputee side were evaluated.

Results: There was a statistically significant relationship between peak hip flexion torque and RLL with the femoral neck BMD T-score (r = 0.327*, p = 0.045; r = 0.432*, p = 0.006, respectively). RLL and peak hip flexion torque were identified as determinants of femoral neck BMD T-score (p = 0.004, p = 0.031, respectively). It was found that for every 1 cm increase in RLL, the femoral neck BMD T-score increased by approximately 0.09. A one-unit increase in peak hip flexion torque was associated with an approximate increase of 0.04 in the ipsilateral femoral neck BMD T-score.

Conclusions: In the rehabilitation program of individuals with unilateral TFA, it may be important to plan hip flexor muscle strengthening interventions that may affect BMD. Performing amputation surgeries while preserving RLL at the longest possible length may be beneficial in terms of BMD results on the amputated side.

介绍/背景：下肢截肢，特别是近端截肢，如经股截肢（TFA），对骨密度（BMD）有负面影响。本研究的目的是确定外伤性单侧TFA患者截肢侧肌肉力量、残肢长度（RLL）和骨密度之间的关系，并探讨其他潜在的相关因素。方法：这是一项回顾性的横断面研究。该研究包括39名TFA患者。记录患者的人口学和临床资料。RLL是通过测量从大转子到残端最远端点的距离来确定的。通过等速系统测定60°/s角速度下的峰值扭矩来评估髋屈肌和伸肌力量。评估截肢侧股骨颈和腰椎双能x线吸收仪（DXA）成像t评分。结果：髋峰值屈曲力矩、RLL与股骨颈BMD t -评分有统计学意义(r = 0.327*,p = 0.045；R = 0.432*,p = 0.006)。RLL和髋峰值屈曲力矩被确定为股骨颈BMD t评分的决定因素（p = 0.004,p = 0.031）。研究发现，RLL每增加1 cm，股骨颈BMD t评分增加约0.09。峰值髋关节屈曲扭矩每增加一个单位，同侧股骨颈BMD t评分约增加0.04。结论：在单侧TFA患者的康复计划中，制定可能影响BMD的髋屈肌强化干预措施可能很重要。在进行截肢手术的同时尽可能长地保留RLL，对于截肢侧的骨密度结果可能是有益的。

{"title":"Bone Mineral Density and Associated Factors in Individuals with Traumatic Unilateral Transfemoral Amputation","authors":"Gizem Kılınç Kamacı, Merve Örücü Atar, Elif Tekin, Fatma Özcan, Yasin Demir, Koray Aydemir","doi":"10.1016/j.jocd.2025.101598","DOIUrl":"10.1016/j.jocd.2025.101598","url":null,"abstract":"<div><div><em>Introduction/background:</em> Lower extremity amputations, particularly at more proximal levels such as transfemoral amputations (TFA)s, negatively affect bone mineral density (BMD). The aim of this study was to determine the relationship between muscle strength, residual limb length (RLL), and BMD on the amputated side in individuals with traumatic unilateral TFA and to investigate other potentially related factors.</div><div><em>Methodology:</em> This is a retrospective, cross-sectional study. The study included 39 individuals with TFA. Demographic and clinical data of the individuals were recorded. RLL was determined by measuring the distance from the trochanter major to the most distal end point of the stump. Hip flexor and extensor muscle strengths were assessed by determining peak torque at an angular velocity of 60°/s using an isokinetic system. Dual-energy X-ray absorptiometry (DXA) imaging T-scores of the femoral neck and lumbar spine on the amputee side were evaluated.</div><div><em>Results:</em> There was a statistically significant relationship between peak hip flexion torque and RLL with the femoral neck BMD T-score (<em>r = </em>0.327*, <em>p = </em>0.045; <em>r = </em>0.432*, <em>p = </em>0.006, respectively). RLL and peak hip flexion torque were identified as determinants of femoral neck BMD T-score (<em>p = </em>0.004, <em>p = </em>0.031, respectively). It was found that for every 1 cm increase in RLL, the femoral neck BMD T-score increased by approximately 0.09. A one-unit increase in peak hip flexion torque was associated with an approximate increase of 0.04 in the ipsilateral femoral neck BMD T-score.</div><div><em>Conclusions:</em> In the rehabilitation program of individuals with unilateral TFA, it may be important to plan hip flexor muscle strengthening interventions that may affect BMD. Performing amputation surgeries while preserving RLL at the longest possible length may be beneficial in terms of BMD results on the amputated side.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 3","pages":"Article 101598"},"PeriodicalIF":1.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy of axial and sagittal CT measurements for osteoporosis: A multi-vertebra evaluation 轴位和矢状位CT测量对骨质疏松症的诊断准确性：多椎体评估

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-06-02 DOI: 10.1016/j.jocd.2025.101596

Sevde Nur Emir, Ahmet Kürşat Soydan, Safiye Sanem Dereli Bulut

Background: This study aims to assess the diagnostic accuracy of axial and sagittal CT-derived Hounsfield Unit (HU) values in identifying osteopenia and osteoporosis. Additionally, it investigates whether the combination of multiple vertebral levels enhances predictive performance compared to single-level assessments.

Methodology: This retrospective study included 346 patients from who underwent both dual-energy X-ray absorptiometry (DXA) and non-contrast thoracic computed tomography (CT) scans within a 6-month interval. Axial and sagittal HU measurements were obtained from key vertebral levels, including T4, T7, T10, T12, and L1. Logistic regression and receiver operating characteristic (ROC) analyses were performed to evaluate the diagnostic performance of individual and combined vertebral models. Patients with vertebral metastases, hemangiomas, compression fractures, or severe deformities were excluded.

Results: The sagittal T4 vertebra measurement achieved the highest individual AUC (0.810), indicating strong diagnostic potential. Combining T4 and L1 measurements improved the AUC to 0.828, while a six-vertebra model yielded a slightly higher AUC of 0.844. Despite this marginal improvement, simpler two-vertebra models offer practical advantages in clinical settings. Optimal cut-off values were determined using Youden’s Index, with T4S at 164 HU and L1S at 133 HU, both showing high specificity but moderate sensitivity.

Conclusions: Axial and sagittal CT measurements, particularly at T4 and L1 levels, demonstrate strong potential for diagnosing osteopenia and osteoporosis. Combining multiple vertebral levels offers improved predictive accuracy, although simpler models remain effective. Opportunistic CT screening, utilizing scans performed for other clinical purposes, provides a practical and cost-effective alternative to DXA, enabling early intervention and comprehensive osteoporosis management.

背景：本研究旨在评估轴向和矢状位ct衍生的Hounsfield Unit （HU）值在识别骨质减少和骨质疏松症中的诊断准确性。此外，它还研究了与单水平评估相比，多个椎体水平的组合是否能提高预测性能。方法：这项回顾性研究包括346名患者，他们在6个月内接受了双能x线吸收仪（DXA）和胸部非对比计算机断层扫描（CT）扫描。轴向和矢状面HU测量来自关键椎体水平，包括T4、T7、T10、T12和L1。采用Logistic回归和受试者工作特征（ROC）分析来评估单个和联合椎体模型的诊断性能。排除有椎体转移、血管瘤、压缩性骨折或严重畸形的患者。结果：矢状面T4椎体测量个体AUC最高（0.810），具有较强的诊断潜力。结合T4和L1测量使AUC提高到0.828，而六椎体模型的AUC略高，为0.844。尽管有这种微小的改进，但更简单的双椎体模型在临床环境中具有实际优势。使用约登指数确定最佳临界值，T4S为164 HU， L1S为133 HU，均具有高特异性，但敏感性中等。结论：轴位和矢状位CT测量，特别是T4和L1水平，显示出诊断骨质减少和骨质疏松症的强大潜力。虽然简单的模型仍然有效，但结合多个椎体水平可以提高预测准确性。机会性CT筛查，利用其他临床目的的扫描，为DXA提供了实用和经济的替代方案，实现了早期干预和全面的骨质疏松症管理。

{"title":"Diagnostic accuracy of axial and sagittal CT measurements for osteoporosis: A multi-vertebra evaluation","authors":"Sevde Nur Emir, Ahmet Kürşat Soydan, Safiye Sanem Dereli Bulut","doi":"10.1016/j.jocd.2025.101596","DOIUrl":"10.1016/j.jocd.2025.101596","url":null,"abstract":"<div><div><em>Background:</em> This study aims to assess the diagnostic accuracy of axial and sagittal CT-derived Hounsfield Unit (HU) values in identifying osteopenia and osteoporosis. Additionally, it investigates whether the combination of multiple vertebral levels enhances predictive performance compared to single-level assessments.</div><div><em>Methodology:</em> This retrospective study included 346 patients from who underwent both dual-energy X-ray absorptiometry (DXA) and non-contrast thoracic computed tomography (CT) scans within a 6-month interval. Axial and sagittal HU measurements were obtained from key vertebral levels, including T4, T7, T10, T12, and L1. Logistic regression and receiver operating characteristic (ROC) analyses were performed to evaluate the diagnostic performance of individual and combined vertebral models. Patients with vertebral metastases, hemangiomas, compression fractures, or severe deformities were excluded.</div><div><em>Results:</em> The sagittal T4 vertebra measurement achieved the highest individual AUC (0.810), indicating strong diagnostic potential. Combining T4 and L1 measurements improved the AUC to 0.828, while a six-vertebra model yielded a slightly higher AUC of 0.844. Despite this marginal improvement, simpler two-vertebra models offer practical advantages in clinical settings. Optimal cut-off values were determined using Youden’s Index, with T4S at 164 HU and L1S at 133 HU, both showing high specificity but moderate sensitivity.</div><div><em>Conclusions:</em> Axial and sagittal CT measurements, particularly at T4 and L1 levels, demonstrate strong potential for diagnosing osteopenia and osteoporosis. Combining multiple vertebral levels offers improved predictive accuracy, although simpler models remain effective. Opportunistic CT screening, utilizing scans performed for other clinical purposes, provides a practical and cost-effective alternative to DXA, enabling early intervention and comprehensive osteoporosis management.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 4","pages":"Article 101596"},"PeriodicalIF":1.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Body Composition Estimates in Hispanic Women by Dual-Energy X-ray Absorptiometry and Hydrostatic Densitometry 用双能x线吸收仪和静压密度仪估算西班牙裔妇女身体成分的比较

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-05-13 DOI: 10.1016/j.jocd.2025.101595

Sarah E. Deemer , Diana E. Kolb , Nicole L. Cipriano , Daniel L. Smith , George A. King

Introduction: Accurate assessment of body composition is critical for understanding health risks and developing appropriate interventions, particularly in underrepresented populations. The purpose of this study was to compare the body composition estimate (% body fat [%BF]) between dual-energy x-ray absorptiometry (DXA) and hydrodensitometry via hydrostatic weighing (HW) in a group of Hispanic pre-menopausal women.

Methodology: Healthy Hispanic women (n=78, age: 22–51 years, BMI: 18.5–42.5) were measured for body composition by DXA and HW at a single lab visit. %BF from HW was calculated from body density using three commonly used adult-specific equations (2-component [2-C] Siri, 2-C Brozek, 3-component [3-C] Lohman) and a 2-C Hispanic-specific equation. Comparisons between the two methods (DXA and HW) were analyzed using paired t-tests, and linear regression and Bland-Altman plots were used to assess agreement between the two methods.

Results: %BF was significantly higher by DXA compared to all four HW equations (P < 0.01). Based on regression analyses the mean difference scores were not different from zero for all estimates of %BF.

Conclusions: While DXA and HW are both common laboratory measures for determining %BF, given the time-efficiency, minimal participant effort, and high precision, %BF estimation by DXA appears to be an adequate and sufficient method of measurement of body composition in Hispanic women.

引言：准确评估身体成分对于了解健康风险和制定适当的干预措施至关重要，特别是在代表性不足的人群中。本研究的目的是比较一组西班牙裔绝经前妇女双能x线吸收仪（DXA）和液体静力称重（HW）的体成分估计值（体脂% [%BF]）。方法：健康的西班牙裔女性（n=78，年龄：22-51岁，BMI: 18.5-42.5）在单次实验室访问时通过DXA和HW测量身体成分。根据体密度，采用三种常用的成人特异性方程（2组分[2-C] Siri， 2组分[2-C] Brozek， 3组分[3-C] Lohman）和2组分[3-C]西班牙裔特异性方程计算BF %。使用配对t检验分析两种方法（DXA和HW）之间的比较，并使用线性回归和Bland-Altman图来评估两种方法之间的一致性。结果：与所有四种HW方程相比，DXA显著提高了BF % (P <；0.01)。基于回归分析，对于所有%BF的估计，平均差异分数与零没有差异。结论：虽然DXA和HW都是确定%BF的常用实验室测量方法，但考虑到时间效率、最小的参与者努力和高精度，DXA估计%BF似乎是西班牙裔女性身体成分测量的适当和充分的方法。

{"title":"Comparison of Body Composition Estimates in Hispanic Women by Dual-Energy X-ray Absorptiometry and Hydrostatic Densitometry","authors":"Sarah E. Deemer , Diana E. Kolb , Nicole L. Cipriano , Daniel L. Smith , George A. King","doi":"10.1016/j.jocd.2025.101595","DOIUrl":"10.1016/j.jocd.2025.101595","url":null,"abstract":"<div><div><em>Introduction:</em> Accurate assessment of body composition is critical for understanding health risks and developing appropriate interventions, particularly in underrepresented populations. The purpose of this study was to compare the body composition estimate (% body fat [%BF]) between dual-energy x-ray absorptiometry (DXA) and hydrodensitometry via hydrostatic weighing (HW) in a group of Hispanic pre-menopausal women.</div><div><em>Methodology:</em> Healthy Hispanic women (n=78, age: 22–51 years, BMI: 18.5–42.5) were measured for body composition by DXA and HW at a single lab visit. %BF from HW was calculated from body density using three commonly used adult-specific equations (2-component [2-C] Siri, 2-C Brozek, 3-component [3-C] Lohman) and a 2-C Hispanic-specific equation. Comparisons between the two methods (DXA and HW) were analyzed using paired t-tests, and linear regression and Bland-Altman plots were used to assess agreement between the two methods.</div><div><em>Results:</em> %BF was significantly higher by DXA compared to all four HW equations (<em>P</em> < 0.01). Based on regression analyses the mean difference scores were not different from zero for all estimates of %BF.</div><div><em>Conclusions:</em> While DXA and HW are both common laboratory measures for determining %BF, given the time-efficiency, minimal participant effort, and high precision, %BF estimation by DXA appears to be an adequate and sufficient method of measurement of body composition in Hispanic women.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"28 3","pages":"Article 101595"},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0