Journal of Clinical Densitometry最新文献_第8页

Composite Indices of Femoral Neck Strength in Young Adult Male Volleyball Players 青年男子排球运动员股骨颈力量综合指标研究

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-30 DOI: 10.1016/j.jocd.2025.101622

Ibrahim Fayad, Antonio Pinti, Hassane Zouhal, Rawad El Hage

引用次数: 0

Assessing the effect of DXA scanner drift on misclassification of bone density change: The Manitoba BMD registry 评估DXA扫描仪漂移对骨密度变化误分类的影响：马尼托巴骨密度登记

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-22 DOI: 10.1016/j.jocd.2025.101620

William D. Leslie , Sajjad Aftabi , John T. Schousboe , Diane Krueger , Neil Binkley

Bone mineral density (BMD) measurement with dual-energy X-ray absorptiometry (DXA) is widely used to assess osteoporosis and monitor BMD in untreated and treated individuals. Systematic sources of error can occur with DXA scanners, including calibration drift. Publications suggest a drift tolerance in the range 0.5 % to 1.5 %, but are not evidence- based. The current study was performed to directly determine how varying degrees of simulated DXA calibration drift would affect misclassification of BMD change in routine clinical practice. Using data from the Manitoba Bone Density Program, we accessed results for 14,942 individuals age 40 years and older undergoing baseline and repeat fan-beam DXA measurements of the total hip within an interval of 1-5 years. A small amount of simulated drift (absolute 0.003 g/cm² or relative 0.25 %) had little effect, and resulted in less than 5 % BMD change misclassification. Misclassification exceeded 10 % with absolute BMD drift greater than 0.006 g/cm² or relative drift over 0.75 %, and was greater than 35 % for absolute BMD drift of 0.024 g/cm². Similar trends were seen when results were stratified according to use of anti-osteoporosis medication, when varying the least significant change (LSC), and for evaluating lumbar spine BMD change. In summary, relatively small degrees of DXA calibration drift can have large effects on misclassifying BMD change. Our results support a calibration drift tolerance of 0.006 g/cm² or 0.5 %. These findings may help to guide timing for DXA scanner servicing and repair.

采用双能x线骨密度仪（DXA）测量骨密度（BMD）被广泛用于评估骨质疏松症和监测未治疗和治疗个体的骨密度。DXA扫描仪可能出现系统性的误差来源，包括校准漂移。出版物建议漂移容忍度在0.5 %至1.5 %之间，但没有证据依据。本研究旨在直接确定不同程度的模拟DXA校准漂移如何影响常规临床实践中BMD变化的错误分类。使用来自马尼托巴骨密度计划的数据，我们访问了14942名年龄在40岁及以上的个体的结果，这些个体在1-5年的间隔内进行了基线和重复的全髋扇形束DXA测量。少量的模拟漂移（绝对0.003 g/cm2或相对0.25 %）影响不大，导致小于5 %的BMD变化误分类。当绝对骨密度漂移大于0.006 g/cm2或相对漂移大于0.75 %时，误分类率超过10 %；当绝对骨密度漂移大于0.024 g/cm2时，误分类率大于35 %。当根据抗骨质疏松药物的使用、改变最不显著变化（LSC）和评估腰椎骨密度变化对结果进行分层时，也可以看到类似的趋势。综上所述，相对较小程度的DXA校准漂移可能对BMD变化的错误分类产生很大影响。我们的结果支持0.006 g/cm2或0.5 %的校准漂移公差。这些发现可能有助于指导DXA扫描仪维修和修复的时机。

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引用次数: 0

Relationships between physical activity and bone mineral content and lean mass in Mexican adolescents 墨西哥青少年体力活动与骨矿物质含量和瘦体重的关系。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-16 DOI: 10.1016/j.jocd.2025.101619

Edgar Denova-Gutiérrez , Desiree López-González , Patricia Clark , Paloma Muñoz-Aguirre , Ricardo Francisco Capozza , Jose Luis Ferretti , Gustavo Roberto Cointry

Introduction/Background: The acquisition and maintenance of bone and lean mass health are significantly influenced by the mechanical environment of the skeleton, with physical activity emerging as an important factor. Our hypothesis proposes that high-impact physical activity improves bone mineral content and lean mass relationship in healthy adolescents depending on gender, pubertal maturity and skeletal location.

Methodology: We assessed the relation between bone mineral content, and lean mass in whole-body and limbs and leisure-time physical activity in Mexican children and adolescents. We conducted an analysis using data from the “Reference values of body composition in Mexican children and adolescents’ study”, which is a population-based, cross-sectional study. Using standardized protocols, Lunar iDXA instrumentation was used to measure whole-body bone mineral content and lean mass. Using a validated questionnaire, adapted for the Mexican population, the leisure-time physical activity level and the “inactive” condition were determined. ANOVA test was conducted to evaluate curve fitness and produce best-fit equations. Additionally, we used ANCOVA test to evaluate the differences between slopes and intercepts of the curves.

Results: All relationships between bone mineral content and lean mass across various regions were highly significant for all Tanner stages (P < 0.001), irrespective of the type of physical activity. Examining all regions (whole-body bone mineral content vs. whole-body lean mass and lower limbs bone mineral content and lean mass, and upper limbs bone mineral content and lean mass) intercepts were significantly higher in Tanner stage 3-5 compared to Tanner stage 1-2 for both genders (P < 0.001).

Conclusion: These results underscore the nuanced impact of leisure-time physical activity and Tanner stage on the observed relationships, suggesting potential benefits of engaging in specific physical activities during adolescence for bone health during the later stages of puberty.

介绍/背景：骨骼的机械环境显著影响骨骼和瘦骨量健康的获得和维持，其中体力活动是一个重要因素。我们的假设提出，高强度的体育活动可以改善健康青少年的骨矿物质含量和瘦质量关系，这取决于性别、青春期成熟度和骨骼位置。方法：我们评估了墨西哥儿童和青少年的骨矿物质含量、全身和四肢瘦质量与闲暇时间体育活动之间的关系。我们使用来自“墨西哥儿童和青少年身体成分参考值研究”的数据进行了分析，这是一项基于人群的横断面研究。采用标准化方案，使用Lunar iDXA仪器测量全身骨矿物质含量和瘦质量。使用一份适用于墨西哥人口的有效问卷，确定了休闲时间的身体活动水平和“不活跃”状态。采用方差分析（ANOVA）检验评价曲线的拟合性，得出最优拟合方程。此外，我们使用ANCOVA检验来评估曲线的斜率和截距之间的差异。结果：骨矿物质含量和瘦体重之间的所有关系在不同地区的所有Tanner阶段都非常显著(P 结论：这些结果强调了休闲时间体育活动和Tanner阶段对观察到的关系的细微影响，表明在青春期后期从事特定的体育活动对骨骼健康有潜在的好处。

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引用次数: 0

The interface of a leaky gut with neuromuscular junction degradation; implications for severe sarcopenia 伴有神经肌肉连接处退化的漏肠界面；对严重肌肉减少症的影响

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-16 DOI: 10.1016/j.jocd.2025.101618

Rizwan Qaisar , Asima Karim , Tahir Muhammad , Shaea A Alkahtani , Firdos Ahmad

Introduction: A pathological increase in intestinal permeability or leaky gut is recently implicated in the pathogenesis of age-associated muscle loss, termed sarcopenia. However, the associated myotoxic effects are poorly known. We investigated the associations of a leaky gut with neuromuscular junction (NMJ) degradation in the context of severe sarcopenia and functional compromise in older adults.

Methodology: This study includes controls (n=161, age=73.4±8.5 years) and severe sarcopenic men (n=148, age=72.4±7.2 years) for measurements of plasma markers of a leaky gut (zonulin), NMJ degradation (CAF22), and bacterial load (lipopolysaccharides-binding protein; LBP). We also measured handgrip strength (HGS), gait speed, and short physical performance battery (SPPB) as sarcopenic and functional compromise markers, respectively.

Results: Severe sarcopenic patients had higher plasma zonulin, CAF22, and LBP levels and lower HGS, gait speed, and SPPB scores than controls (all p<0.05). We found significant correlations between plasma zonulin and CAF22 in controls and severe sarcopenic men (both p<0.05). The presence of severe sarcopenia and SPPB scores < 9 were associated with strengthening the correlation between zonulin and CAF22 (p<0.05). Higher plasma zonulin and CAF22 were associated with higher plasma LBP, lower HGS and gait speed, and lower SPPB scores (all p<0.05).

Conclusion: Collectively, severe sarcopenia and functional compromise due to intestinal leak may involve NMJ degradation and higher plasma bacterial load. Future studies should establish the causal and mechanistic associations between intestinal leak and sarcopenia in old age.

导读：肠通透性或漏肠的病理增加最近与年龄相关的肌肉损失的发病机制有关，称为肌肉减少症。然而，相关的肌毒性作用尚不清楚。我们研究了在老年人严重肌肉减少症和功能损害的情况下，漏肠与神经肌肉接头（NMJ）退化的关系。方法：本研究纳入对照组（n=161，年龄=73.4±8.5岁）和重度肌少症男性（n=148，年龄=72.4±7.2岁），测量漏肠血浆标志物（zonulin）、NMJ降解（CAF22）和细菌负荷(脂多糖结合蛋白；LBP)。我们还分别测量了握力（HGS）、步态速度和短物理性能电池（SPPB）作为肌肉减少和功能损害的标志。结果：重度肌少症患者血浆zonulin、CAF22和LBP水平高于对照组，HGS、步态速度和SPPB评分低于对照组（p < 0.05）。我们发现血浆zonulin和CAF22在对照组和严重肌少症男性中存在显著相关性（p < 0.05）。存在严重的肌肉减少症和SPPB评分<；9例与zonulin与CAF22相关性增强相关（p < 0.05）。较高的血浆zonulin和CAF22与较高的血浆LBP、较低的HGS和步态速度以及较低的SPPB评分相关（均p < 0.05）。结论：肠道渗漏引起的严重肌肉减少症和功能损害可能与NMJ降解和血浆细菌负荷升高有关。未来的研究应该建立肠道渗漏和老年肌肉减少症之间的因果关系和机制联系。

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引用次数: 0

Bone health of underprivileged Indian children with type-1 diabetes one year after discontinuation of milk and pharmacological calcium supplementation: a follow-up study 贫困的印度1型糖尿病儿童在停止牛奶和药理学补钙一年后的骨骼健康：一项随访研究

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-08 DOI: 10.1016/j.jocd.2025.101616

Dr. Chirantap Oza, Dr. Anuradha Khadilkar, Dr. Neha Kajale, Dr. Shital Bhor, Dr. Dipali Ladkat, Dr. Raja Padidela, Dr. Zulf Mughal

引用次数: 0

Development of AI model for dual detection of low bone mineral density in the femoral neck and lumbar vertebrae using chest radiographs 利用胸片双重检测股骨颈和腰椎低骨密度的AI模型的开发

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-08 DOI: 10.1016/j.jocd.2025.101604

Yukino Ohta , Kouichi Yamamoto , Yutaka Katayama , Takahiro Ideta , Hiroaki Matsuzawa , Takao Ichida , Akane Utsunomiya , Takayuki Ishida

Introduction: Artificial intelligence (AI) technologies have demonstrated high accuracy in detecting overall osteoporosis on chest radiographs, offering significant potential for rapid and accessible osteoporosis screening. However, as bone loss varies by lifestyle and body shape, detecting low bone mineral density (BMD) in specific parts is crucial for early treatment. This study developed and evaluated two deep learning models to detect low BMD in the femoral neck and lumbar vertebrae.

Methods: Data included chest radiographs and dual-energy X-ray absorptiometry (DXA)-measured BMD values [g/cm²] of 2,728 female examinees. Chest radiographs were categorized into low BMD or normal based on the femoral neck (low: 1,358, normal: 1,370) and lumbar vertebrae (low: 562, normal: 2,166). Deep learning models were trained using the ResNet50 architecture with fine-tuning and 10-fold cross-validation. Performance metrics included sensitivity, specificity, overall accuracy, and area under the curve (AUC). Heatmaps generated using Explainable AI visualized regions related to low BMD.

Results: The model achieved 75.3 % overall accuracy (AUC: 0.82) for femoral neck detection and 89.3 % (AUC: 0.96) for lumbar vertebrae detection. Lumbar vertebrae detection showed 14.0 % higher accuracy than the femoral neck. Patients with lumbar vertebrae low BMD exhibited more advanced bone loss compared to those with femoral neck low BMD alone. Heatmaps indicated relevant regions near the clavicle and thoracic vertebrae.

Conclusion: The proposed model accurately detected low BMD in chest radiographs and identified areas of bone loss, demonstrating particularly high performance in lumbar vertebrae detection. Early identification of low BMD enables simple, effective screening and targeted prevention or treatment based on areas of bone loss.

人工智能（AI）技术在胸部x线片上检测整体骨质疏松症的准确性很高，为快速和容易获得的骨质疏松症筛查提供了巨大的潜力。然而，由于骨质流失因生活方式和体型而异，检测特定部位的低骨密度（BMD）对于早期治疗至关重要。本研究开发并评估了两种深度学习模型，用于检测股骨颈和腰椎的低骨密度。方法：资料包括2,728名女性体检者的胸片和双能x线骨密度仪（DXA）测量的骨密度值[g/cm2]。胸片根据股骨颈（低：1358，正常：1370）和腰椎（低：562，正常：2166）分为低骨密度或正常。深度学习模型使用ResNet50架构进行训练，并进行微调和10倍交叉验证。性能指标包括灵敏度、特异性、总体准确度和曲线下面积（AUC）。使用可解释的人工智能生成的与低骨密度相关的可视化区域热图。结果：该模型对股骨颈检测的总准确率为75.3 % (AUC: 0.82)，腰椎检测的总准确率为89.3% % （AUC: 0.96）。腰椎检测的准确率比股骨颈高14.0 %。腰椎骨密度低的患者比单纯股骨颈骨密度低的患者表现出更严重的骨质流失。热图显示锁骨和胸椎附近的相关区域。结论：该模型能准确地检测胸片中的低骨密度，并识别骨质流失区域，在腰椎检测方面表现出特别高的性能。早期发现低骨密度可以简单、有效地进行筛查，并根据骨质流失的区域进行针对性的预防或治疗。

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引用次数: 0

The Relationship Between Antihypertensive Drugs and Osteoporosis in Postmenopausal Women: The ADiOS Study 绝经后妇女降压药与骨质疏松的关系：ADiOS研究

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-04 DOI: 10.1016/j.jocd.2025.101607

Pelin Analay , Murat Kara , Hatice Gülgün Fırat , Ahmet Furkan Çolak , Kübra Erdoğan , Mahmud Fazıl Aksakal , Berkay Yalçınkaya , Kübranur Demirel , Hazal Sevinç , Sena Küçüktoksöz , Hilmi Berkan Abacıoğlu , Mustafa Güngör Albayrak , Alpaslan Fatih Kaynar , Orhun Tunahan Cingöz , Ahmad Jasem Abdulsalam , Özgür Kara , Ahmet Sertçelik , Bayram Kaymak , Banu Çakır , Levent Özçakar

Introduction: Hypertension (HT) and osteoporosis (OP) are common chronic diseases that often coexist in postmenopausal women. This study aimed to investigate the association between the use of antihypertensive medications and the presence of OP.

Methods: We retrospectively analyzed the medical records of 4166 postmenopausal women. Demographic data, age, weight, height, comorbidities, medications and bone mineral density values were collected for all patients screened/followed for OP between 2023 and 2024.

Results: Out of 4166 postmenopausal women, 1659 (39.8 %) were diagnosed with OP. After adjusting for potential confounders using binary logistic regression, diabetes mellitus [OR=0.785 (95 % CI=0.667-0.925) p = 0.004] and hyperlipidemia [OR=0.826 (95 % CI=0.698-0.978) p = 0.026] were negatively associated with OP. Among the antihypertensive medications (N = 2144); furosemide use [OR=1.918 (95 % CI=1.157-3.182) p = 0.012] was positively associated with OP, while thiazide use showed a negative association [OR=0.769 (95 % CI=0.619-0.954) p = 0.017].

Conclusions: Thiazide use was associated with a lower likelihood of OP, while furosemide use was linked to increased odds (about 1.9 times). Further research with larger samples and stratified analyses of antihypertensive classes is warranted to better understand these associations.

高血压（HT）和骨质疏松症（OP）是绝经后妇女常见的慢性疾病。本研究旨在探讨降压药的使用与op的关系。方法：回顾性分析4166例绝经后妇女的医疗记录。收集2023年至2024年间所有OP筛查/随访患者的人口统计学数据、年龄、体重、身高、合并症、药物和骨密度值。结果：在4166名绝经后妇女中，1659名（39.8%）被诊断为op。使用二元logistic回归校正潜在混杂因素后，糖尿病[OR=0.785 (95% CI=0.667-0.925) p = 0.004]和高脂血症[OR=0.826 (95% CI=0.698-0.978) p = 0.026]与op呈负相关。降压药物（N = 2144）；速尿使用与OP呈正相关[OR=1.918 (95% CI=1.157 ~ 3.182) p = 0.012]，噻嗪类药物使用与OP呈负相关[OR=0.769 (95% CI=0.619 ~ 0.954) p = 0.017]。结论：噻嗪类药物的使用与OP的可能性降低有关，而速尿的使用与OP的可能性增加有关（约1.9倍）。为了更好地了解这些关联，有必要进一步研究更大的样本和降压药类别的分层分析。

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引用次数: 0

Diagnosing osteoporosis despite Schmorl’s nodes and ankylosing spondylitis 诊断骨质疏松症，尽管施莫尔淋巴结和强直性脊柱炎

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-04 DOI: 10.1016/j.jocd.2025.101608

Hilmi Berkan Abacıoğlu, Pelin Analay, Murat Kara, Levent Özçakar

引用次数: 0

Changes in lean mass and fat mass in children with Osteogenesis Imperfecta 成骨不全症患儿瘦脂肪量的变化

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-04 DOI: 10.1016/j.jocd.2025.101605

Holly Wright , Sze Choong Wong , Misha Gilani , Helen McDevitt , Sheila Shepherd , Avril Mason

Background: Deficits in skeletal muscle and function, with resultant abnormal body composition, is a recognised feature of Osteogenesis Imperfecta (OI). Less is known about longitudinal change in body composition in OI. Our objective was to perform a retrospective analysis of longitudinal change in body composition (lean mass and fat mass) in children with OI.

Methodology: Data was collected from 29 children, with a diagnosis of OI, who had at least two dual-energy x-ray absorptiometry (DXA) scans performed between 2015 and 2022. Assessed variables of height, body mass index (BMI), lean mass index (LMI) and fat mass index (FMI), were converted to z scores. Results were reported as median (range).

Results: Median age at baseline and follow-up were 10.7 and 14.2 years, respectively. Median height z-score at baseline was -1.10, which was significantly lower than a control population (p<0.001). Median height z-score at latest follow-up was -0.80, which was not significantly different from baseline (p=0.870). Median BMI z-score at baseline was 0.15, which was not significantly different than a control population (p=0.804). Median BMI z-score at latest follow-up was 0.02, which was not significantly different from baseline (p=0.730). At baseline, median LMI z-score was -2.43, which was significantly lower than a control population (p<0.001). Median LMI z-score at follow-up was -1.78, which was not significantly different from baseline (p=0.080). At baseline, median FMI z-score was 0.57 which was significantly higher than a control population (p=0.001). Median FMI z-score at follow-up was 0.62, which was not significantly different from baseline (p=0.540).

Conclusion: Children with OI have abnormal body composition throughout childhood typically with low lean mass and relatively high fat mass. These abnormalities in body composition do not change with follow-up. Strategies to improve lean mass, including physical or medical therapies, should be explored in OI given the close relationship between muscle and bone.

背景：骨骼肌和功能缺陷，以及由此导致的身体成分异常，是成骨不全症（OI）的一个公认特征。对于成骨不全患者体内成分的纵向变化了解较少。我们的目的是对成骨不全儿童身体组成（瘦质量和脂肪质量）的纵向变化进行回顾性分析。方法：收集29名诊断为成骨不全的儿童的数据，这些儿童在2015年至2022年期间至少进行了两次双能x线吸收仪（DXA）扫描。评估变量身高、身体质量指数（BMI）、瘦质量指数（LMI）和脂肪质量指数（FMI）转换为z分数。结果以中位数（范围）报告。结果：基线和随访时的中位年龄分别为10.7岁和14.2岁。基线时身高z得分中位数为-1.10，显著低于对照人群（p<0.001）。最新随访中位身高z得分为-0.80，与基线无显著差异（p=0.870）。基线时BMI z评分中位数为0.15，与对照组相比差异无统计学意义（p=0.804）。最新随访时BMI z评分中位数为0.02，与基线无显著差异（p=0.730）。基线时，LMI z-score中位数为-2.43，显著低于对照组（p<0.001）。随访时LMI z-score中位数为-1.78，与基线无显著差异（p=0.080）。基线时，FMI z-score中位数为0.57，显著高于对照组（p=0.001）。随访时FMI z-score中位数为0.62，与基线无显著差异（p=0.540）。结论：成骨不全儿童在整个儿童期均存在身体成分异常，典型表现为低瘦体质量和相对高脂体质量。这些身体成分的异常不随随访而改变。考虑到肌肉和骨骼之间的密切关系，在成骨不全症中应该探索改善瘦质量的策略，包括物理或药物治疗。

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引用次数: 0

Effect of Radiation Therapy on CT Attenuation of Bone in Patients with Anorectal Cancer Treated with Chemotherapy 放疗对化疗肛肠癌患者骨CT衰减的影响

IF 1.7 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2025-07-01 DOI: 10.1016/j.jocd.2025.101597

Gary K. Schneider , Jason A. Benedict , Jennifer Matsui , Gavin Wu , Michael Ruesch , Rahul Prasad , Pannaga Malalur , Vedat Yildiz , Eric Miller , Steven W. Ing

Radiation therapy (RT), a standard treatment modality for locally advanced anorectal cancer, may be followed by pelvic fractures, but there are currently no formal recommendations to evaluate bone health prior to RT. Recent studies have demonstrated CT attenuation measurement of lumbar vertebrae as a surrogate marker of bone mineral density (BMD). In this single-institution retrospective cohort analysis of patients with anorectal carcinoma treated with RT, we assess lumbar and sacral CT attenuation before and after RT. CT scans of 302 patients with at least one pre- and post- RT CT scan including all of L1, L3, L5, and sacrum were reviewed, and CT attenuation measured at each level. All CT scans were obtained for either cancer surveillance or other medically indicated reason. CT attenuation measurements were adjusted for presence of IV contrast and nonstandard CT tube voltage. Prior to RT, mean bone attenuation at L1, L3, L5, and sacrum were 158.4, 151.1, 157.8, and 231.0 HU respectively. Three months post-RT, L1 and L3 had mean differences of +1.7 (+1.1 %) and −7.7 (−5.1 %) HU, respectively, while L5 and sacrum had mean differences of −48.8 (−31.0 %) and −65.9 (−28.6 %) HU, respectively. There was little to no evidence of further decrease at any vertebral level beyond three months after RT, nor was there evidence for increase in HU beyond three months, by which time RT courses were completed. This suggests that bone loss from RT is associated with proximity to the radiation field and the majority of the observed decline occurs within the first three months following the start of RT.

放射治疗（RT）是局部晚期肛管直肠癌的标准治疗方式，可能会在盆腔骨折之后进行，但目前没有正式的建议在放疗之前评估骨骼健康。最近的研究表明，腰椎CT衰减测量可以作为骨矿物质密度（BMD）的替代指标。在这项单机构回顾性队列分析中，我们评估了接受RT治疗的肛肠癌患者在RT前后的腰椎和骶骨CT衰减。我们回顾了302例患者的CT扫描，这些患者至少进行了一次RT前后的CT扫描，包括L1、L3、L5和骶骨，并测量了每个级别的CT衰减。所有的CT扫描都是为了癌症监测或其他医学上的原因。根据静脉造影剂和非标准CT管电压的存在调整CT衰减测量。放疗前，L1、L3、L5和骶骨的平均骨衰减分别为158.4、151.1、157.8和231.0 HU。术后3个月，L1和L3的平均差异分别为+1.7（+1.1 %）和- 7.7(- 5.1 %)HU， L5和骶骨的平均差异分别为- 48.8（- 31.0 %）和- 65.9(- 28.6 %)HU。在放疗后3个月后，几乎没有证据表明任何椎体水平进一步下降，也没有证据表明3个月后HU增加，到那时放疗课程完成。这表明放射治疗导致的骨质流失与靠近放射场有关，大部分观察到的骨质流失发生在放射治疗开始后的前三个月内。

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引用次数: 0