International Journal of Methods in Psychiatric Research最新文献_第8页

Can neurological soft signs and neurocognitive deficits serve as a combined endophenotype for Han Chinese with bipolar disorder? 神经软征和神经认知缺陷可以作为汉族双相情感障碍的联合内表型吗?

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-04-10 DOI: 10.1002/mpr.1970

Yingying Feng, Jia Song, Guorong Lin, Hong Qian, Li Feng, Zongqin Wang, Juan Wen, Chengchen Wang, Jiayuan Wang, Peifu Li, Zuohui Gao, Xiaoli Wang, Xiaohua Hu

Background

Bipolar disorder's (BD) potential endophenotypes include neurological soft signs (NSS) and neurocognitive disorders (ND). Few research, meanwhile, has coupled NSS and ND as combined endophenotypes of BD.

Object

This study intends to investigate NSS and ND and compare their differences in euthymic patients with bipolar disorder (EBP), their unaffected first-degree relatives (FDR), and healthy controls (HC). Additionally, search for potential endophenotypic subprojects of NSS and ND and construct and verify a composite endophenotypic.

Methods

The subjects were all Han Chinese and consisted of 86 EBP, 81 FDR, and 81HC. Cambridge Neurological Inventory and MATRICS^TM Consensus Cognitive Battery tested NSS and ND independently.

Results

All three groups displayed a trapezoidal distribution of NSS levels and cognitive abnormalities, with EBP having the most severe NSS levels and cognitive deficits, followed by FDR and HC. Among them, motor coordination in NSS and Information processing speed (IPS), Verbal learning (VL), and Working memory (WM) in neurocognitive function are consistent with the traits of the endophenotype of BD. The accuracy in differentiating EBP and HC or FDRs and HC was higher when these items were combined as predictor factors than in differentiating EBP and FDR.

Conclusion

These results provide more evidence that motor coordination, IPS, VL, and WM may be internal characteristics of bipolar disease. When these characteristics are combined into a complex endophenotype, it may be possible to distinguish BD patients and high-risk groups from normal populations.

背景:双相情感障碍(BD)的潜在内表型包括神经软体征(NSS)和神经认知障碍(ND)。目的:探讨NSS和ND在双相情感障碍(EBP)、未患病一级亲属(FDR)和健康对照(HC)中存在的差异，并进行比较。此外，寻找NSS和ND潜在的内表型子项目，构建并验证复合内表型。方法:受试者均为汉族，EBP 86例，FDR 81例，hc 81例。剑桥神经量表和matristm共识认知电池独立测试了NSS和ND。结果:三组患者NSS水平及认知异常均呈梯形分布，其中EBP患者NSS水平及认知缺陷最严重，FDR和HC患者次之。其中，NSS中的运动协调性和神经认知功能中的信息加工速度(IPS)、言语学习(VL)、工作记忆(WM)与BD的内表型特征一致，将EBP和HC或FDRs作为预测因素时，区分EBP和FDR的准确性高于区分EBP和FDR的准确性。结论:这些结果进一步证明运动协调、IPS、VL和WM可能是双相情感障碍的内在特征。当这些特征结合成复杂的内表型时，就有可能将BD患者和高危人群与正常人群区分开来。

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引用次数: 0

Networks of C-reactive protein and depression symptoms in patients with stable coronary heart disease: Findings from the Heart and Soul Study 稳定型冠心病患者的c反应蛋白网络与抑郁症状:来自心脏与灵魂研究的发现

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-04-10 DOI: 10.1002/mpr.1968

Chiyoung Lee, Mary A. Whooley

Objective

Research addressing the associations between C-reactive protein (CRP) and depression among patients with stable coronary heart disease (CHD) has produced inconsistent results. This might be attributable to varying associations of CRP with specific depression symptom profiles. We responded to this challenge using various network analysis techniques.

Methods

A total of 967 outpatients with documented CHD were drawn from the baseline cross-sectional data of the Heart and Soul Study. We first estimated mixed graphical models that included CRP and individual depression symptoms, before and after adjusting for relevant covariates, to explore whether CRP is correlated with specific facets of depression. We also investigated whether CRP levels moderated the associations between specific depression symptoms using moderated network models. Finally, we performed a network comparison test and compared the symptom network properties between non-elevated and elevated CRP groups.

Results

In the network model without covariates, CRP was positively associated with fatigue, appetite changes, and psychomotor problems. CRP maintained its negative association with concentration difficulty regardless of covariate adjustment. Few symptom-symptom associations, especially those involving appetite changes, were moderated by CRP. Further, the elevated CRP group showed greater overall symptom connectivity as compared to the non-elevated group.

Conclusion

This study segues into CRP-depression relationship with sophisticated methodology.

目的:研究稳定型冠心病(CHD)患者c反应蛋白(CRP)与抑郁之间的关系，结果不一致。这可能归因于CRP与特定抑郁症状的不同关联。我们使用各种网络分析技术来应对这一挑战。方法:从心脏与灵魂研究的基线横断面数据中抽取967例有记录的冠心病门诊患者。我们首先估计了包括CRP和个体抑郁症状的混合图形模型，在调整相关协变量之前和之后，以探索CRP是否与抑郁症的特定方面相关。我们还使用调节网络模型研究了CRP水平是否能调节特定抑郁症状之间的关联。最后，我们进行了网络比较测试，比较了CRP未升高组和CRP升高组之间的症状网络特性。结果:在无协变量的网络模型中，CRP与疲劳、食欲变化和精神运动问题呈正相关。无论协变量调整如何，CRP与浓度困难保持负相关。很少有症状-症状的关联，尤其是那些涉及食欲变化的，被CRP所缓和。此外，与非升高组相比，CRP升高组表现出更大的整体症状连通性。结论:本研究采用完善的研究方法，深入探讨了crp与抑郁的关系。

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引用次数: 0

Measuring media-related health and mental health information acquisition among Latino adults in the United States 测量美国拉丁裔成年人与媒体相关的健康和心理健康信息获取。

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-03-28 DOI: 10.1002/mpr.1967

Melissa J. DuPont-Reyes, Alice Villatoro, Giovanni Gama, Lu Tang

Objectives

We developed and evaluated new media-related health information acquisition measures for U.S.-based Latino populations.

Methods

In 2021, a sample of U.S.-based Latino adults (N = 1574) self-completed a 20-min survey of health information acquisition measures across three language/cultural dimensions: Spanish media, Latino-tailored media in English, and general media in English. Socio-demographics were also ascertained. Means and standard deviations for the health acquisition measures were adjusted for age and sex and reported across nativity status.

Results

The sample was diverse across age, gender, race, ethnicity, socioeconomic status, migration, and language competency. Internal consistency reliability of developed scales was excellent overall and within age, gender, race, ethnicity, and socioeconomic subgroups (Cronbach's alphas = 0.86–0.94). English media scales had higher means overall indicating higher prolonged quantity (i.e., dosage) than Spanish media scales. In contrast, standard deviations for Spanish media scales were higher overall indicating broader reach at lower doses than English media scales.

Conclusions

Findings suggest English-language media is popular among Latino populations overall. However, Spanish-language media retains broad reach through both passive and active exposure. Our findings demonstrate the value of including more nuanced measurement of health information acquisition such as the scales developed in this study to improve health promotion among Latino populations.

目的:我们为美国拉丁裔人口开发并评估了新的与媒体相关的健康信息获取措施。方法:2021年，美国拉丁裔成年人样本(N = 1574)自我完成了一项20分钟的健康信息获取措施调查，涉及三个语言/文化维度:西班牙语媒体、拉丁裔量身定制的英语媒体和普通英语媒体。还确定了社会人口统计学。根据年龄和性别调整健康获取措施的平均值和标准偏差，并根据出生状况进行报告。结果:样本在年龄、性别、种族、民族、社会经济地位、移民和语言能力方面存在差异。已开发量表的内部一致性信度总体上和在年龄、性别、种族、民族和社会经济亚组内都是优秀的(Cronbach's alpha = 0.86-0.94)。与西班牙语量表相比，英语量表总体平均值较高，表明延长时间(即剂量)较高。相比之下，西班牙语介质量表的标准偏差总体上较高，表明较低剂量下的覆盖范围比英语介质量表大。结论:研究结果表明，英语媒体在拉丁裔人群中普遍受欢迎。然而，西班牙语媒体通过被动和主动曝光保持了广泛的影响力。我们的研究结果表明，包括更细致的健康信息获取测量的价值，如本研究中开发的量表，以改善拉丁裔人口的健康促进。

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引用次数: 0

The German version of the Revised Children's Anxiety and Depression Scale—Psychometric properties and normative data for German 8- to 17-year-olds 德文版修订儿童焦虑抑郁量表——德国8 ~ 17岁儿童的心理测量特征及标准数据。

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-03-15 DOI: 10.1002/mpr.1965

Susanne Grothus, Ariane Sommer, Benedikt B. Claus, Lorin Stahlschmidt, Bruce F. Chorpita, Julia Wager

Objectives

Anxiety and depression are internalizing mental disorders often commencing in childhood and manifesting in adolescence. The Revised Anxiety and Depression Scale (RCADS) is an internationally widely used standardized diagnostic tool, but the German version has only been validated in a pediatric chronic pain sample; normative data are not available. The aim of this study is to test its reliability (internal consistency) and validity (factorial, convergent, known-groups) in a representative German school sample and to provide norm data.

Methods

Data were collected from N = 1562 German schoolchildren (M_age = 12.2; SD_age = 2.33; range 8–17 years; 52.4% girls).

Results

Cronbach's α ranged from 0.73 to 0.96 for the total and the six subscales (five anxiety and one depression). Confirmatory factor analysis showed the 6-factor model had acceptable to good model fit with CFI = 0.93, TLI = 0.93, RMSEA = 0.05, SRMR = 0.05, which was better than 1- and 2-factor models. The (sub)scales correlated moderate to high negatively with health-related quality of life (−0.31 ≤ τ ≤ −0.51; p < 0.001) and positively with functional impairment (0.31 ≤ τ ≤ 0.48; p < 0.001). Mean scores of anxiety and depression scales were significantly higher in girls and partly in adolescents.

Conclusion

Findings provide support for the good psychometric properties of the German RCADS in a community sample.

目的:焦虑和抑郁是一种内在化的精神障碍，通常始于童年，表现于青春期。修订焦虑和抑郁量表(RCADS)是国际上广泛使用的标准化诊断工具，但德国版本仅在儿科慢性疼痛样本中得到验证;没有标准数据。本研究的目的是在具有代表性的德国学校样本中测试其信度(内部一致性)和效度(析因，收敛，已知组)，并提供规范数据。方法:收集德国学龄儿童N = 1562例(Mage = 12.2;SDage = 2.33;8-17岁;52.4%的女孩)。结果:总量表和6个量表(5个焦虑量表和1个抑郁量表)的Cronbach's α值在0.73 ~ 0.96之间。验证性因子分析表明，6因素模型具有较好的模型拟合，CFI = 0.93, TLI = 0.93, RMSEA = 0.05, SRMR = 0.05，优于1因素和2因素模型。(亚)量表与健康相关生活质量呈中高负相关(-0.31≤τ≤-0.51;p结论:研究结果支持德国RCADS在社区样本中具有良好的心理测量特性。

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引用次数: 0

Measurement invariance across age, gender, ethnicity, and psychopathology of the Psychotic-Like Experiences Questionnaire for Children in a community sample 社区样本儿童类精神病经历问卷的年龄、性别、种族和精神病理测量不变性。

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-03-02 DOI: 10.1002/mpr.1962

Lauren M. Piltz, Emma J. Carpendale, Kristin R. Laurens

Objectives

The current study aimed to assess the measurement invariance of the 9-item self-report Psychotic-Like Experiences Questionnaire for Children (PLEQ-C) across various demographic (age, gender, ethnicity) and psychopathology profiles in a community sample of children.

Methods

Children aged 9–11 years (n = 613; M age = 10.4 years [SD = 0.8]; 50.9% female) completed questionnaire screening at school, with primary caregivers returning questionnaires by mail from home. Configural, metric, scalar, and residual invariance of the PLEQ-C scores were investigated across groups differentiated by age (9; 10; 11 years), gender (female; male), ethnicity (white; black; other), and by child-reported and caregiver-reported psychopathology (abnormal rating; not abnormal).

Results

The PLEQ-C scores demonstrated good unidimensional model fit. Full configural, metric, scalar, and residual invariance were demonstrated across gender, ethnicity, and psychopathology (both child- and caregiver-reported). Across age groups, the PLEQ-C scores showed full configural and metric invariance, but only partial scalar and residual invariance (with a single item measuring differently among 11-year-olds).

Conclusions

In this community sample, the PLEQ-C was robust to age, gender, ethnicity, and psychopathology profiles, providing evidence of its capacity to identify children in the general population who might benefit from further assessment to determine the clinical significance of their psychotic experiences.

目的:本研究旨在评估9项儿童类精神病经历自我报告问卷(PLEQ-C)在不同人口统计(年龄、性别、种族)和社区儿童精神病理特征中的测量不变性。方法:9-11岁儿童(n = 613;M年龄= 10.4岁[SD = 0.8];(50.9%为女性)在学校完成问卷筛选，主要照顾者从家中邮寄问卷。PLEQ-C分数的结构、度量、标量和残差不变性在不同年龄的组中进行了研究(9;10;11岁)，性别(女;男性)，种族(白人;黑色;其他)，以及儿童报告和照顾者报告的精神病理(异常评级;没有异常)。结果:PLEQ-C得分表现出良好的一维模型拟合。完整的构形、度量、标量和残差不变性在性别、种族和精神病理(儿童和护理人员报告)中均得到证明。在不同年龄组中，PLEQ-C得分表现出完全的结构和度量不变性，但只有部分标量不变性和残差不变性(在11岁儿童中，单个项目的测量结果不同)。结论:在这个社区样本中，PLEQ-C对年龄、性别、种族和精神病理特征都是稳健的，这证明了它有能力在普通人群中识别出可能从进一步评估中受益的儿童，以确定他们的精神病经历的临床意义。

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引用次数: 1

Educational level and the risk of mental disorders, substance use disorders and self-harm in different age-groups: A cohort study covering 1,6 million subjects in the Stockholm region 不同年龄组的教育水平与精神障碍、物质使用障碍和自残风险:斯德哥尔摩地区一项涵盖160万受试者的队列研究。

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-02-17 DOI: 10.1002/mpr.1964

Baojing Li, Peter Allebeck, Bo Burstöm, Anna-Karin Danielsson, Louisa Degenhardt, Terje A. Eikemo, Alize Ferrari, Ann Kristin Knudsen, Andreas Lundin, Hélio Manhica, John Newton, Harvey Whiteford, Pär Flodin, Hugo Sjöqvist, Emilie E. Agardh

Objective

To investigate the associations between low education and risk of mental disorders, substance use disorders and self-harm in different age-groups.

Methods

All subjects in Stockholm born between 1931 and 1990 were linked to their own or their parent's highest education in 2000 and followed-up for these disorders in health care registers 2001–2016. Subjects were stratified into four age-groups: 10–18, 19–27, 28–50, and 51–70 years. Hazard Ratios with 95% Confidence Intervals (CIs) were estimated with Cox proportional hazard models.

Results

Low education increased the risk of substance use disorders and self-harm in all age-groups. Males aged 10–18 with low education had increased risks of ADHD and conduct disorders, and females a decreased risk of anorexia, bulimia and autism. Those aged 19–27 years had increased risks of anxiety and depression, and those aged 28–50 had increased risks of all mental disorders except anorexia and bulimia in males with Hazard Ratios ranging from 1.2 (95% CIs 1.0–1.3) for bipolar disorder to 5.4 (95% CIs 5.1–5.7) for drug use disorder. Females aged 51–70 years had increased risks of schizophrenia and autism.

Conclusion

Low education is associated with risk of most mental disorders, substance use disorders and self-harm in all age-groups, but especially among those aged 28–50 years.

目的:探讨不同年龄人群低文化程度与精神障碍、物质使用障碍和自残风险的关系。方法:所有出生于1931年至1990年的斯德哥尔摩受试者在2000年与自己或父母的最高教育程度相关，并在2001年至2016年期间在医疗保健登记册中随访这些疾病。受试者分为4个年龄组:10-18岁、19-27岁、28-50岁和51-70岁。采用Cox比例风险模型估计95%置信区间(ci)的风险比。结果:低教育水平增加了所有年龄组物质使用障碍和自残的风险。10-18岁受教育程度低的男性患多动症和行为障碍的风险增加，而女性患厌食症、贪食症和自闭症的风险降低。19-27岁的男性焦虑和抑郁风险增加，28-50岁的男性除厌食症和贪食症外所有精神障碍风险增加，风险比从双相情感障碍的1.2 (95% ci 1.0-1.3)到药物使用障碍的5.4 (95% ci 5.1-5.7)不等。51-70岁的女性患精神分裂症和自闭症的风险增加。结论:低教育程度与所有年龄组的大多数精神障碍、物质使用障碍和自残风险相关，但在28-50岁人群中尤为明显。

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引用次数: 1

Differential symptom weighting in estimating empirical thresholds for underlying PTSD severity: Toward a “platinum” standard for diagnosis? 评估潜在创伤后应激障碍严重程度的经验阈值的差异症状加权:迈向诊断的“白金”标准?

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-02-15 DOI: 10.1002/mpr.1963

Antonio A. Morgan-López, Lissette M. Saavedra, Denise A. Hien, Sonya B. Norman, Skye S. Fitzpatrick, Ai Ye, Therese K. Killeen, Lesia M. Ruglass, Shannon M. Blakey, Sudie E. Back

Objective

Symptom counts as the basis for Post-Traumatic Stress Disorder (PTSD) diagnoses in the DSM presume each symptom is equally reflective of underlying disorder severity. However, the “equal weight” assumption fails to fit PTSD symptom data when tested. The present study developed an enhanced PTSD diagnosis based on (a) a conventional PTSD diagnosis from a clinical interview and (b) an empirical classification of full PTSD that reflected the relative clinical weights of each symptom.

Method

Baseline structured interview data from Project Harmony (N = 2658) was used. An enhanced diagnosis for full PTSD was estimated using an empirical threshold from moderated nonlinear factor analysis (MNLFA) latent PTSD scale scores, in combination with a full conventional PTSD diagnosis based on interview data.

Results

One in 4 patients in the sample had a PTSD diagnosis that was inconsistent with their empirical PTSD grouping, such that the enhanced diagnostic standard reduced the diagnostic discrepancy rate by 20%. Veterans, and in particular female Veterans, were at greatest odds for discrepancy between their underlying PTSD severity and DSM diagnosis.

Conclusion

Psychometric methodologies that differentially weight symptoms can complement DSM criteria and may serve as a platform for symptom prioritization for diagnoses in future editions of DSM.

客观症状作为DSM中创伤后应激障碍(PTSD)诊断的基础，假设每种症状都同样反映了潜在障碍的严重程度。然而，“同等权重”假设在测试时不符合PTSD症状数据。本研究基于(a)来自临床访谈的常规PTSD诊断和(b)反映每种症状的相对临床权重的完整PTSD的经验分类，开发了一种增强的PTSD诊断。方法采用Harmony项目的基线结构化访谈数据(N = 2658)。利用调节非线性因子分析(MNLFA)潜在PTSD量表得分的经验阈值，结合基于访谈数据的完全常规PTSD诊断，估计增强诊断为完全PTSD。结果样本中每4例患者中就有1例的PTSD诊断与其经验PTSD分组不一致，提高后的诊断标准使诊断差异率降低了20%。退伍军人，尤其是女性退伍军人，其潜在的创伤后应激障碍严重程度与DSM诊断之间的差异最大。结论不同体重症状的心理测量方法可作为DSM标准的补充，并可作为未来DSM版本中诊断症状优先级的平台。

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引用次数: 1

Latent anxiety and depression dimensions differ amongst patients with eating disorders: A Swedish nationwide investigation 饮食失调患者的潜在焦虑和抑郁维度不同:瑞典全国调查

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-02-12 DOI: 10.1002/mpr.1961

Christopher Hübel, Andreas Birgegård, Therese Johansson, Liselotte V. Petersen, Rasmus Isomaa, Moritz Herle

Objective

Anxiety and depression symptoms are common in individuals with eating disorders. To study these co-occurrences, we need high-quality self-report questionnaires. The 19-item self-rated Comprehensive Psychopathological Rating Scale for Affective Syndromes (CPRS-S-A) is not validated in patients with eating disorders. We tested its factor structure, invariance, and differences in its latent dimensions.

Method

Patients were registered by 45 treatment units in the Swedish nationwide Stepwise quality assurance database for specialised eating disorder care (n = 9509). Patients self-reported their anxiety and depression symptoms on the CPRS-S-A. Analyses included exploratory and confirmatory factor analyses (CFA) in split samples, and testing of invariance and differences in subscales across eating disorder types.

Results

Results suggested a four-factor solution: Depression, Somatic and fear symptoms, Disinterest, and Worry. Multigroup CFA indicated an invariant factor structure. We detected the following differences: Patients with anorexia nervosa binge-eating/purging subtype scored the highest and patients with unspecified feeding and eating disorders the lowest on all subscales. Patients with anorexia nervosa or purging disorder show more somatic and fear symptoms than individuals with either bulimia nervosa or binge-eating disorder.

Conclusion

Our four-factor solution of the CPRS-S-A is suitable for patients with eating disorders and may help to identify differences in anxiety and depression dimensions amongst patients with eating disorders.

焦虑和抑郁症状在饮食失调患者中很常见。为了研究这些共现现象，我们需要高质量的自我报告问卷。19项自评情感综合征综合精神病理评定量表(CPRS-S-A)未在饮食失调患者中得到验证。我们测试了它的因素结构、不变性和潜在维度的差异。方法在瑞典全国逐步质量保证数据库中对45个治疗单位的患者进行登记，用于专门的饮食失调治疗(n = 9509)。患者在CPRS-S-A中自我报告焦虑和抑郁症状。分析包括在分裂样本中进行探索性和验证性因素分析(CFA)，并测试饮食失调类型的亚量表的不变性和差异。结果提出了四因素解决方案:抑郁、躯体和恐惧症状、冷漠和担忧。多组CFA显示因子结构不变。我们发现了以下差异:神经性厌食症暴食/泻食亚型患者在所有亚量表上得分最高，未指明的进食障碍患者得分最低。神经性厌食症或排便障碍患者比神经性贪食症或暴食症患者表现出更多的躯体和恐惧症状。结论本研究的四因素CPRS-S-A量表适用于进食障碍患者，有助于识别进食障碍患者焦虑和抑郁维度的差异。

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引用次数: 0

Mapping length of inpatient treatment duration and year-wise relapse rates in eating disordered populations in a well-defined Western-European healthcare region across 1998–2020 1998-2020年，在一个明确定义的西欧医疗保健地区，饮食失调人群的住院治疗时间和年度复发率的制图长度

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-01-30 DOI: 10.1002/mpr.1960

Peter Andersson, Esmail Jamshidi, Carl-Johan Ekman, Kristina Tedroff, Jonnie Björkander, Magnus Sjögren, Johan Lundberg, Jussi Jokinen, Adrian E. Desai Boström

Objectives

Updated international guideline recommendations for AN inpatient care rely on expert opinions/observational evidence and promote extended inpatient stays, warranting investigation using higher-level ecological evidence.

Methods

The study was conducted according to Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Data encompassing 13,885 ED inpatients (5336 adolescents and 8549 adults) was retrieved from Swedish public health registries. Variables analyzed included (1) ED inpatient care opportunities, (2) unique number of ED inpatients and (3) mean length of ED-related inpatient stays in age groups 15–19 and 20–88+, across 1998–2020.

Results

Mean length of inpatient stays was inversely correlated to relapse to ED-related inpatient care within the same year (p < 0.001, R-squared_adj = 0.5216 and p < 0.00001, R-squared_adj = 0.5090, in the 15–19 and 20–88+ age groups, respectively), independent of number of ED inpatients treated within a year in both age groups. Extending mean adolescent inpatient duration from 35 to 45 days was associated with a ∼30% reduction in the year-wise relapse rate.

Conclusions

Mean length of ED-related inpatient treatment stays was associated with reduced relapses to inpatient care within the same year, which could be interpreted as support for recommendations to include a stabilization phase in inpatient ED treatment.

目的:更新的国际急性呼吸道感染住院治疗指南建议依赖于专家意见/观察证据，并促进延长住院时间，保证使用更高水平的生态证据进行调查。方法:根据准确透明的健康评估报告指南(GATHER)进行研究。从瑞典公共卫生登记处检索了13885名ED住院患者(5336名青少年和8549名成年人)的数据。分析的变量包括:(1)1998-2020年期间，ED住院治疗机会;(2)ED住院患者的独特数量;(3)15-19岁和20-88岁以上年龄组ED相关住院患者的平均住院时间。结果:平均住院时间与同一年内ED相关住院治疗的复发呈负相关(15-19岁和20-88岁以上年龄组分别为p = 0.5216和p = 0.5090)，与两年龄组一年内ED住院治疗的次数无关。将青少年平均住院时间从35天延长至45天，可使年复发率降低约30%。结论:ED相关住院治疗的平均时间与同一年内住院治疗复发的减少有关，这可以解释为支持在ED住院治疗中加入稳定阶段的建议。

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引用次数: 1

Harmonizing bifactor models of psychopathology between distinct assessment instruments: Reliability, measurement invariance, and authenticity 协调不同评估工具之间的精神病理学双因素模型:信度、测量不变性和真实性

IF 3.1 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research

Pub Date : 2023-01-19 DOI: 10.1002/mpr.1959

Maurício Scopel Hoffmann, Tyler Maxwell Moore, Luiza Kvitko Axelrud, Nim Tottenham, Luis Augusto Rohde, Michael Peter Milham, Theodore Daniel Satterthwaite, Giovanni Abrahão Salum

Objectives

Model configuration is important for mental health data harmonization. We provide a method to investigate the performance of different bifactor model configurations to harmonize different instruments.

Methods

We used data from six samples from the Reproducible Brain Charts initiative (N = 8,606, ages 5–22 years, 41.0% females). We harmonized items from two psychopathology instruments, Child Behavior Checklist (CBCL) and GOASSESS, based on semantic content. We estimated bifactor models using confirmatory factor analysis, and calculated their model fit, factor reliability, between-instrument invariance, and authenticity (i.e., the correlation and factor score difference between the harmonized and original models).

Results

Five out of 12 model configurations presented acceptable fit and were instrument-invariant. Correlations between the harmonized factor scores and the original full-item models were high for the p-factor (>0.89) and small to moderate (0.12–0.81) for the specific factors. 6.3%–50.9% of participants presented factor score differences between harmonized and original models higher than 0.5 z-score.

Conclusions

The CBCL-GOASSESS harmonization indicates that few models provide reliable specific factors and are instrument-invariant. Moreover, authenticity was high for the p-factor and moderate for specific factors. Future studies can use this framework to examine the impact of harmonizing instruments in psychiatric research.

目的模型配置对心理健康数据的协调具有重要意义。我们提供了一种方法来研究不同双因子模型配置的性能，以协调不同的仪器。方法使用来自可重复脑图计划的6个样本的数据(N = 8,606，年龄5-22岁，女性41.0%)。我们根据语义内容对儿童行为检查表(Child Behavior Checklist, CBCL)和goevaluate两种精神病理学工具中的项目进行了协调。我们使用验证性因子分析来估计双因子模型，并计算它们的模型拟合、因子信度、工具间不变性和真实性(即协调模型与原始模型之间的相关性和因子得分差异)。结果12个模型配置中有5个具有可接受的拟合和工具不变性。协调因子得分与原始全项目模型之间的相关性在p因子上为高(>0.89)，在特定因子上为小到中等(0.12-0.81)。6.3% ~ 50.9%的被试提出的因子得分与原始模型之间的差异大于0.5 z-score。结论cbcl - goevaluate的协调表明，很少有模型能提供可靠的特定因子，并且具有工具不变性。p因子的真实性较高，特异因子的真实性较低。未来的研究可以使用这个框架来检查协调工具在精神病学研究中的影响。

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引用次数: 0