Pub Date : 2024-07-05DOI: 10.21608/bmfj.2024.291651.2087
Rasha M Abd-Rabh, Sara G Masoud, Ragaey R Fahmy, A. M. Elbalshy, Sara N Nasif
: Background: Breast cancer (BC) is the most common malignant tumor in females worldwide. It is categorized into four main molecular subtypes. Ubiquitin-conjugating enzyme (UBE2C) is essential for the ubiquitin–proteasome system which regulates checkpoints in the cell cycle. Dysregulation of ubiquitination has been associated with different types of cancer. P53 is important tumor suppressor gene. In some cancers mutant p53 proteins not only lose tumor suppressive functions, but also acquire oncogenic activity. Aim: This study aims at evaluation of UBE2C and P53 expression in molecular subtypes of breast cancer and assessment of their role in pathogenesis and tumor progression.
{"title":"Significance of Ubiquitin-Conjugating Enzyme (UBE2C) and P53 Expression in Molecular Subtypes of Breast Carcinoma; An Immunohistochemical Study","authors":"Rasha M Abd-Rabh, Sara G Masoud, Ragaey R Fahmy, A. M. Elbalshy, Sara N Nasif","doi":"10.21608/bmfj.2024.291651.2087","DOIUrl":"https://doi.org/10.21608/bmfj.2024.291651.2087","url":null,"abstract":": Background: Breast cancer (BC) is the most common malignant tumor in females worldwide. It is categorized into four main molecular subtypes. Ubiquitin-conjugating enzyme (UBE2C) is essential for the ubiquitin–proteasome system which regulates checkpoints in the cell cycle. Dysregulation of ubiquitination has been associated with different types of cancer. P53 is important tumor suppressor gene. In some cancers mutant p53 proteins not only lose tumor suppressive functions, but also acquire oncogenic activity. Aim: This study aims at evaluation of UBE2C and P53 expression in molecular subtypes of breast cancer and assessment of their role in pathogenesis and tumor progression.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-05DOI: 10.21608/bmfj.2024.273744.2029
Maha Mamdouh Osman, Amany Ibrahim Mustafa, Karim Reda Karim, Fatma Mohamed Mohamed Elesawy
: Background: Vitiligo is a depigmenting skin condition due to the attenuation of melanin in the affected skin area due to specific melanocyte loss. The pathophysiology of vitiligo has been linked to both mitochondrial malfunction and oxidative stress. Dynamin-related protein 1 (DRP1) is a regulator of mitochondrial fission. Uncoupling Protein 2 (UCP2) is an essential mitochondrial protein that regulates cellular energy metabolism. Objectives: This study aimed to assess the gene expression levels of UCP2 and DRP1 in vitiligo patients and correlate those levels with the activity and severity of the disease. Methods: This case-control study included 40 vitiligo patients and 40 age and sex matched healthy controls. Gene expression levels of UCP2 and Drp1 were measured using an enzyme-linked immunosorbent assay. Results: The vitiligo group had significantly higher serum UCP2 and Drp1 gene expression levels (p<0.001 for each) When compared to the control group. UCP2 gene expression showed a significant negative correlation with VIDA score (p<0.001). Drp1 gene expression showed significant negative correlations with age and duration of vitiligo (p=0.002, 0.001 respectively) and a positive correlation with VIDA score (p<0.001). Conclusions: The findings suggest the potential role of dysregulation of Drp1 and UCP2 gene expression in vitiligo. For patients with vitiligo, both markers showed prognostic and diagnostic values.
:背景：白癜风是一种脱色性皮肤病，由于特定的黑色素细胞脱失导致患处皮肤黑色素减少。白癜风的病理生理学与线粒体功能失调和氧化应激有关。Dynamin-related protein 1（DRP1）是线粒体裂变的调节剂。解偶联蛋白2（UCP2）是一种重要的线粒体蛋白，可调节细胞能量代谢。研究目的本研究旨在评估白癜风患者体内 UCP2 和 DRP1 的基因表达水平，并将这些水平与疾病的活动性和严重程度相关联。方法：本病例对照研究纳入了 40 名白癜风患者：这项病例对照研究包括 40 名白癜风患者和 40 名年龄和性别匹配的健康对照者。采用酶联免疫吸附试验测定了 UCP2 和 Drp1 的基因表达水平。结果显示与对照组相比，白癜风组的血清 UCP2 和 Drp1 基因表达水平明显更高（P<0.001）。UCP2 基因表达与 VIDA 评分呈显著负相关（p<0.001）。Drp1 基因表达与年龄和白癜风病程呈显著负相关（分别为 p=0.002 和 0.001），与 VIDA 评分呈正相关（p<0.001）。结论研究结果表明，Drp1和UCP2基因表达失调在白癜风中具有潜在作用。对于白癜风患者来说，这两个标记物具有预后和诊断价值。
{"title":"Uncoupling Protein 2 and Dynamin-related Protein1 mRNA Gene Expression as possible key Markers of activity and severity of Vitiligo","authors":"Maha Mamdouh Osman, Amany Ibrahim Mustafa, Karim Reda Karim, Fatma Mohamed Mohamed Elesawy","doi":"10.21608/bmfj.2024.273744.2029","DOIUrl":"https://doi.org/10.21608/bmfj.2024.273744.2029","url":null,"abstract":": Background: Vitiligo is a depigmenting skin condition due to the attenuation of melanin in the affected skin area due to specific melanocyte loss. The pathophysiology of vitiligo has been linked to both mitochondrial malfunction and oxidative stress. Dynamin-related protein 1 (DRP1) is a regulator of mitochondrial fission. Uncoupling Protein 2 (UCP2) is an essential mitochondrial protein that regulates cellular energy metabolism. Objectives: This study aimed to assess the gene expression levels of UCP2 and DRP1 in vitiligo patients and correlate those levels with the activity and severity of the disease. Methods: This case-control study included 40 vitiligo patients and 40 age and sex matched healthy controls. Gene expression levels of UCP2 and Drp1 were measured using an enzyme-linked immunosorbent assay. Results: The vitiligo group had significantly higher serum UCP2 and Drp1 gene expression levels (p<0.001 for each) When compared to the control group. UCP2 gene expression showed a significant negative correlation with VIDA score (p<0.001). Drp1 gene expression showed significant negative correlations with age and duration of vitiligo (p=0.002, 0.001 respectively) and a positive correlation with VIDA score (p<0.001). Conclusions: The findings suggest the potential role of dysregulation of Drp1 and UCP2 gene expression in vitiligo. For patients with vitiligo, both markers showed prognostic and diagnostic values.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-05DOI: 10.21608/bmfj.2024.276428.2038
Ehab Shalaby, Sameh Elsharaawy, Ahmed Saleh, A. Elnoury, Haitham Mostafa
: Background: Postoperative pain can seriously reduce the quality of life in patients, and acute pain can even trigger chronic pain syndrome. We aimed to compare efficacy of adding PECS block under general anesthesia with preoperative oral multimodal Analgesia (MMA) or alone on postoperative opioid consumption in subjects undergoing breast surgery. Methods: This prospective double-blinded randomized controlled study was conducted on 120 adult women underwent breast surgeries. Patients were randomly allocated into 3 equal groups; group I, only MMA was administered, group II; both PECS and MMA were administered and group III only PECS was administered. All patients were evaluated full clinical assessment and laboratory investigations. In group I, preoperative MMA with oral acetaminophen 975 mg and/or gabapentin 600 mg as preventive analgesia was given within 2 hours prior to surgery. Results: There was an insignificant difference among the studied groups regarding the VAS at all time measurement and perioperative opioid consumption. The incidence of PONV and the need for PONV rescue medication were significantly different among the studied group, being less prevalent in group C followed by group B (P=0.001, 0.001). Conclusions: We found comparable results in the postoperative VAS score and perioperative opioid consumption suggesting that the use of PECS block combined with MMA may not reduce intraoperative and/or postoperative opioid consumption in subjects undergoing elective breast surgery. However, the incidence of PONV was less prevalent in PECS group followed by PECS block combined with MMA.
{"title":"Addition of PECS Block to Multimodal Analgesia for Postoperative Analgesia after Breast Cancer Surgery: A Randomized Clinical Trial","authors":"Ehab Shalaby, Sameh Elsharaawy, Ahmed Saleh, A. Elnoury, Haitham Mostafa","doi":"10.21608/bmfj.2024.276428.2038","DOIUrl":"https://doi.org/10.21608/bmfj.2024.276428.2038","url":null,"abstract":": Background: Postoperative pain can seriously reduce the quality of life in patients, and acute pain can even trigger chronic pain syndrome. We aimed to compare efficacy of adding PECS block under general anesthesia with preoperative oral multimodal Analgesia (MMA) or alone on postoperative opioid consumption in subjects undergoing breast surgery. Methods: This prospective double-blinded randomized controlled study was conducted on 120 adult women underwent breast surgeries. Patients were randomly allocated into 3 equal groups; group I, only MMA was administered, group II; both PECS and MMA were administered and group III only PECS was administered. All patients were evaluated full clinical assessment and laboratory investigations. In group I, preoperative MMA with oral acetaminophen 975 mg and/or gabapentin 600 mg as preventive analgesia was given within 2 hours prior to surgery. Results: There was an insignificant difference among the studied groups regarding the VAS at all time measurement and perioperative opioid consumption. The incidence of PONV and the need for PONV rescue medication were significantly different among the studied group, being less prevalent in group C followed by group B (P=0.001, 0.001). Conclusions: We found comparable results in the postoperative VAS score and perioperative opioid consumption suggesting that the use of PECS block combined with MMA may not reduce intraoperative and/or postoperative opioid consumption in subjects undergoing elective breast surgery. However, the incidence of PONV was less prevalent in PECS group followed by PECS block combined with MMA.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-05DOI: 10.21608/bmfj.2024.267590.2014
Marwa M. Nageeb, Amany Farouk Mohamed El Fakahany, Amina Ibrahim Abd El Maaboud, Safaa Hassanien Youssif, Fatma Ahmed Hegab, Ghada Helmy Omar
: Background: Cryptosporidium parvum is an intracellular coccidial protozoa that can lead to life-threatening impacts in immunocompromised hosts. Atorvastatin may be used to treat human cryptosporidiosis. Nanomedicine developments appear promising in treatment of cryptosporidiosis. Purpose: The aim of this work is to evaluate the efficacy of atorvastatin loaded on nano-particles on treatment of cryptosporidiosis. Methods: Cryptosporidium oocysts were obtained by collection of stools from naturally infected calves. Both
{"title":"Efficacy of Atorvastatin Loaded on Nano Particles on Cryptosporidium Parvum in Experimentally Infected Mice","authors":"Marwa M. Nageeb, Amany Farouk Mohamed El Fakahany, Amina Ibrahim Abd El Maaboud, Safaa Hassanien Youssif, Fatma Ahmed Hegab, Ghada Helmy Omar","doi":"10.21608/bmfj.2024.267590.2014","DOIUrl":"https://doi.org/10.21608/bmfj.2024.267590.2014","url":null,"abstract":": Background: Cryptosporidium parvum is an intracellular coccidial protozoa that can lead to life-threatening impacts in immunocompromised hosts. Atorvastatin may be used to treat human cryptosporidiosis. Nanomedicine developments appear promising in treatment of cryptosporidiosis. Purpose: The aim of this work is to evaluate the efficacy of atorvastatin loaded on nano-particles on treatment of cryptosporidiosis. Methods: Cryptosporidium oocysts were obtained by collection of stools from naturally infected calves. Both","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-05DOI: 10.21608/bmfj.2024.290175.2083
Eman Badr Elshibiny, Essam Eldeen Shohaeb, mohamed Gamal masoud
: Background: Precise evaluation of Central Corneal Thickness (CCT) is crucial for both tracking the activity of corneal endothelial cells and detecting corneal disorders including keratoconus and Fuchs Endothelial Corneal Dystrophy. The aim of this work was to use pentacam to measure CCT and generate CCT maps in diabetic patients with and without retinopathy and contrast those with normal subjects. Patients
{"title":"Comparative Study of Central Corneal Thickness in Healthy Individuals and Diabetic Patients with and Without Retinopathy using Pentacam","authors":"Eman Badr Elshibiny, Essam Eldeen Shohaeb, mohamed Gamal masoud","doi":"10.21608/bmfj.2024.290175.2083","DOIUrl":"https://doi.org/10.21608/bmfj.2024.290175.2083","url":null,"abstract":": Background: Precise evaluation of Central Corneal Thickness (CCT) is crucial for both tracking the activity of corneal endothelial cells and detecting corneal disorders including keratoconus and Fuchs Endothelial Corneal Dystrophy. The aim of this work was to use pentacam to measure CCT and generate CCT maps in diabetic patients with and without retinopathy and contrast those with normal subjects. Patients","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-09DOI: 10.21608/bmfj.2024.289866.2081
I. Rageh, Enas Sebaey Ahmad, Mohamed Nagy El-Mohamady, Mirna Mashhour, Rehab Adel Zeiada, Dina Abdelmotaleb
: Background: The incidence of diabetes mellitus is rapidly increasing, and it frequently causes considerable metabolic disorders and serious consequences. MicroRNA-200b (miR-200b) is a regulator of angiogenesis that has emerged as a diagnostic and predictive tool for certain disorders. Aim: to investigate the association of miR-200b with diabetic retinopathy (DR). Methods: The study included 100 subjects from Benha University Hospital: 40 patients with type 2 diabetes (T2D) without DR, 40 with T2D and DR, and 20 apparently healthy controls. MicroRNA-200b was assessed for all subjects using real time PCR with SYBR Green. Results: Diabetics had lower levels of miR-200b than healthy controls. While, those without DR had even lower miR-200b levels compared to those who did have DR. Additionally, lower miR-200b levels were associated with neuropathy but not with nephropathy. Conclusion: MiR-200b showed promise as a biomarker for both T2D and DR. It perfectly differentiated diabetic patients with and without retinopathy, while offering moderate accuracy for diagnosing diabetes in general. These findings suggest miR-200b may play a risky role in DR among diabetics, and further research is warranted to confirm these results.
:背景：糖尿病的发病率正在迅速上升，而且经常导致相当大的代谢紊乱和严重后果。微RNA-200b（miR-200b）是血管生成的调节因子，已成为某些疾病的诊断和预测工具。目的：研究 miR-200b 与糖尿病视网膜病变（DR）的关系。研究方法研究对象包括本哈大学医院的 100 名受试者：40名未患有糖尿病视网膜病变的2型糖尿病（T2D）患者、40名患有糖尿病视网膜病变的T2D患者和20名表面健康的对照组。使用 SYBR Green 实时 PCR 对所有受试者的 MicroRNA-200b 进行评估。结果显示糖尿病患者的 miR-200b 水平低于健康对照组。与患有 DR 的人相比，没有患有 DR 的人的 miR-200b 水平更低。此外，较低的 miR-200b 水平与神经病变有关，但与肾病变无关。结论MiR-200b有望成为T2D和DR的生物标记物。它能完美地区分有视网膜病变和无视网膜病变的糖尿病患者，同时对一般糖尿病的诊断也有一定的准确性。这些研究结果表明，miR-200b 可能对糖尿病患者的 DR 起着风险作用，需要进一步的研究来证实这些结果。
{"title":"Plasma level of MiR- 200b in type 2 diabetic retinopathy in Egyptian patients","authors":"I. Rageh, Enas Sebaey Ahmad, Mohamed Nagy El-Mohamady, Mirna Mashhour, Rehab Adel Zeiada, Dina Abdelmotaleb","doi":"10.21608/bmfj.2024.289866.2081","DOIUrl":"https://doi.org/10.21608/bmfj.2024.289866.2081","url":null,"abstract":": Background: The incidence of diabetes mellitus is rapidly increasing, and it frequently causes considerable metabolic disorders and serious consequences. MicroRNA-200b (miR-200b) is a regulator of angiogenesis that has emerged as a diagnostic and predictive tool for certain disorders. Aim: to investigate the association of miR-200b with diabetic retinopathy (DR). Methods: The study included 100 subjects from Benha University Hospital: 40 patients with type 2 diabetes (T2D) without DR, 40 with T2D and DR, and 20 apparently healthy controls. MicroRNA-200b was assessed for all subjects using real time PCR with SYBR Green. Results: Diabetics had lower levels of miR-200b than healthy controls. While, those without DR had even lower miR-200b levels compared to those who did have DR. Additionally, lower miR-200b levels were associated with neuropathy but not with nephropathy. Conclusion: MiR-200b showed promise as a biomarker for both T2D and DR. It perfectly differentiated diabetic patients with and without retinopathy, while offering moderate accuracy for diagnosing diabetes in general. These findings suggest miR-200b may play a risky role in DR among diabetics, and further research is warranted to confirm these results.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141367843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-09DOI: 10.21608/bmfj.2024.288374.2077
Mohamed Gamal El Din El Ashhab, Fahim Ali Mandour, Hesham Ali El Attar
: Background: Dislocation after revision total hip arthroplasty (THA) continues to be one of the most common and concerning complications after the procedure. Dual-mobility (DM) acetabular components decrease the risk of post-operative instability also in high-risk patients, both in primary and revision hip arthroplasty. This study aimed to evaluate the outcome of DM acetabular cup (DMC) for instability in THA. Methods: This prospective study included 20 patients with Hip abductor insufficiency underwent total hip replacement using dual mobility cup. Complete local examination of the involved hip joint and radiological evaluation to ensure precise templating The Harris hip score (HHS) is used for clinical evaluation of patients at 6 weeks, 3months, 6 months, and the last follow-up. Standard radiographs are taken for all patients at subsequent follow-up examinations to examine component position or migration, osteolysis and loosening, and union of transfemoral osteotomy if used. Results: Regarding the prothesis, Cementless cup-Cementless stem was used in 3 (15.0%) patients, Cemented cup-Cementless stem was used in 9 (45.0%) patients and Cemented cup-Cemented stem was used in 8 (40.0%) patients. Harris hip score is improved over time postoperatively. HHS was significantly higher after 6 wks., after 6 months and after 1 years compared to preoperative HHS. Conclusion: the use of DMC has been found to be an effective technique for preventing hip arthroplasty instability. The clinical outcomes achieved with DMC were quite satisfactory, and the incidence of complications was significantly lower compared to other techniques.
{"title":"Outcome of dual mobility Acetabular cup for instability in total hip Arthroplasty","authors":"Mohamed Gamal El Din El Ashhab, Fahim Ali Mandour, Hesham Ali El Attar","doi":"10.21608/bmfj.2024.288374.2077","DOIUrl":"https://doi.org/10.21608/bmfj.2024.288374.2077","url":null,"abstract":": Background: Dislocation after revision total hip arthroplasty (THA) continues to be one of the most common and concerning complications after the procedure. Dual-mobility (DM) acetabular components decrease the risk of post-operative instability also in high-risk patients, both in primary and revision hip arthroplasty. This study aimed to evaluate the outcome of DM acetabular cup (DMC) for instability in THA. Methods: This prospective study included 20 patients with Hip abductor insufficiency underwent total hip replacement using dual mobility cup. Complete local examination of the involved hip joint and radiological evaluation to ensure precise templating The Harris hip score (HHS) is used for clinical evaluation of patients at 6 weeks, 3months, 6 months, and the last follow-up. Standard radiographs are taken for all patients at subsequent follow-up examinations to examine component position or migration, osteolysis and loosening, and union of transfemoral osteotomy if used. Results: Regarding the prothesis, Cementless cup-Cementless stem was used in 3 (15.0%) patients, Cemented cup-Cementless stem was used in 9 (45.0%) patients and Cemented cup-Cemented stem was used in 8 (40.0%) patients. Harris hip score is improved over time postoperatively. HHS was significantly higher after 6 wks., after 6 months and after 1 years compared to preoperative HHS. Conclusion: the use of DMC has been found to be an effective technique for preventing hip arthroplasty instability. The clinical outcomes achieved with DMC were quite satisfactory, and the incidence of complications was significantly lower compared to other techniques.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141366592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-09DOI: 10.21608/bmfj.2024.274818.2035
Amr M. El Hammady, Medhat A.Khalil, Y. Marei, Mahasen Hamdy Mohammed Ahmed, Mysara M Mogahed
: Background: Deficiency of vitamin D has become a global public health problem, with nearly 1 billion people worldwide being in a state of vitamin D insufficiency or deficiency. The aim of this work was to evaluate the role of hypovitaminosis D in diabetes-related anemia of chronic disease and value of its replacement in response to therapy. Methods: This randomized control trial included patients with diabetes-related anemia of chronic disease), the least number is 318 patients. The three groups were randomized equally; group 1 was with diabetes-related anemia of chronic disease) with normal 25 hydroxy vitamin D and received treatment for anemia, group 2 was with diabetes-related anemia of chronic disease with low level of 25 hydroxy vitamin D, and group 3 was with diabetes, but no anemia then follows up for hemoglobin concentration. Those Patients were informed about using vitamin D in treatment (benefits and side effects) in addition to treatment of specific anemia, then we assessed anemia after three months. Results: The study found no significant difference in age, sex, or type of diabetes mellitus (DM) between groups. However, individuals with anemia, particularly those with low vitamin D levels, had lower serum iron and TIBC levels and higher ferritin levels. Vitamin D levels were negatively correlated with ferritin and positively correlated with iron and TIBC. HbA1C levels had negative correlations with iron, TIBC, and WBCs. Conclusion: The current study suggested that there was close relationship between vitamin D deficiency and anemia in diabetic patients.
:背景：维生素 D 缺乏已成为一个全球性的公共卫生问题，全球有近 10 亿人处于维生素 D 不足或缺乏状态。这项工作的目的是评估维生素 D 不足在糖尿病相关慢性病贫血中的作用，以及在治疗过程中补充维生素 D 的价值。方法：随机对照试验这项随机对照试验包括糖尿病相关慢性病贫血患者（最少为 318 人）。随机平均分为三组：第 1 组为 25 羟基维生素 D 正常的糖尿病相关慢性病贫血患者，接受贫血治疗；第 2 组为 25 羟基维生素 D 水平较低的糖尿病相关慢性病贫血患者；第 3 组为有糖尿病但无贫血的患者，随访血红蛋白浓度。除了治疗特定的贫血外，我们还向这些患者介绍了在治疗中使用维生素 D 的好处和副作用，然后我们在三个月后对贫血情况进行了评估。结果研究发现，各组之间在年龄、性别或糖尿病（DM）类型上没有明显差异。然而，贫血患者，尤其是维生素 D 水平低的患者，血清铁和 TIBC 水平较低，铁蛋白水平较高。维生素 D 水平与铁蛋白呈负相关，与铁和 TIBC 呈正相关。HbA1C 水平与铁、TIBC 和白细胞呈负相关。结论本研究表明，糖尿病患者维生素 D 缺乏与贫血之间存在密切关系。
{"title":"Role of Hypovitaminosis D in Diabetes-Related Anemia of Chronic Disease and Value of Its Replacement in Response to Therapy: A Randomized Control Trial","authors":"Amr M. El Hammady, Medhat A.Khalil, Y. Marei, Mahasen Hamdy Mohammed Ahmed, Mysara M Mogahed","doi":"10.21608/bmfj.2024.274818.2035","DOIUrl":"https://doi.org/10.21608/bmfj.2024.274818.2035","url":null,"abstract":": Background: Deficiency of vitamin D has become a global public health problem, with nearly 1 billion people worldwide being in a state of vitamin D insufficiency or deficiency. The aim of this work was to evaluate the role of hypovitaminosis D in diabetes-related anemia of chronic disease and value of its replacement in response to therapy. Methods: This randomized control trial included patients with diabetes-related anemia of chronic disease), the least number is 318 patients. The three groups were randomized equally; group 1 was with diabetes-related anemia of chronic disease) with normal 25 hydroxy vitamin D and received treatment for anemia, group 2 was with diabetes-related anemia of chronic disease with low level of 25 hydroxy vitamin D, and group 3 was with diabetes, but no anemia then follows up for hemoglobin concentration. Those Patients were informed about using vitamin D in treatment (benefits and side effects) in addition to treatment of specific anemia, then we assessed anemia after three months. Results: The study found no significant difference in age, sex, or type of diabetes mellitus (DM) between groups. However, individuals with anemia, particularly those with low vitamin D levels, had lower serum iron and TIBC levels and higher ferritin levels. Vitamin D levels were negatively correlated with ferritin and positively correlated with iron and TIBC. HbA1C levels had negative correlations with iron, TIBC, and WBCs. Conclusion: The current study suggested that there was close relationship between vitamin D deficiency and anemia in diabetic patients.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141367335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-02DOI: 10.21608/bmfj.2024.259655.1991
F. F. Negm, T. Assar, Doaa Samy Saad Abo Salem, H. Abdelbaset
Background: Understanding the implications of maternal oxygenation during elective cesarean sections with spinal anesthesia on neonatal outcomes is crucial for optimizing perinatal care. This study aimed to determine the effect of maternal oxygenation on neonatal outcome in full term elective cesarean section under spinal anesthesia. Methods: This randomized controlled trial, conducted from June to December 2022 at Benha University Hospital, included pregnant patients beyond 37 weeks of gestation undergoing elective cesarean section. Participants were divided into two groups: Group A received oxygen supplementation, while Group B did not. Various assessments, including maternal and neonatal parameters, were conducted. Results : Group A exhibited significantly higher maternal oxygen levels (100 ± 0 vs. 95 ± 1, P < 0.001). Neonates in Group A demonstrated lower umbilical vein carbon dioxide (35.3 ± 6.4 vs. 39.4 ± 7.8, P = 0.013) and bicarbonate levels (19.3 ± 2.7 vs. 21.6 ± 5.3, P = 0.019) but higher oxygen levels (34 ± 6 vs. 22 ± 4, P < 0.001). Apgar scores were higher in Group A at 1 minute (median = 9 vs. 8, P = 0.023), 10 minutes (median = 10 vs. 9, P < 0.001), and 20 minutes. Group A neonates also had significantly higher oxygen levels at 1, 3, 5, and 10 minutes post-delivery but there was no statistically significant difference in admission rate. Conclusion: Maternal oxygenation during elective cesarean sections may positively influences neonatal outcomes, as evidenced by improved Apgar scores and higher neonatal oxygen levels but no effect on admission rate.
{"title":"Effect of Maternal Oxygenation with Spinal Anesthesia on Neonatal Outcome in Full Term Elective Cesarean Section","authors":"F. F. Negm, T. Assar, Doaa Samy Saad Abo Salem, H. Abdelbaset","doi":"10.21608/bmfj.2024.259655.1991","DOIUrl":"https://doi.org/10.21608/bmfj.2024.259655.1991","url":null,"abstract":"Background: Understanding the implications of maternal oxygenation during elective cesarean sections with spinal anesthesia on neonatal outcomes is crucial for optimizing perinatal care. This study aimed to determine the effect of maternal oxygenation on neonatal outcome in full term elective cesarean section under spinal anesthesia. Methods: This randomized controlled trial, conducted from June to December 2022 at Benha University Hospital, included pregnant patients beyond 37 weeks of gestation undergoing elective cesarean section. Participants were divided into two groups: Group A received oxygen supplementation, while Group B did not. Various assessments, including maternal and neonatal parameters, were conducted. Results : Group A exhibited significantly higher maternal oxygen levels (100 ± 0 vs. 95 ± 1, P < 0.001). Neonates in Group A demonstrated lower umbilical vein carbon dioxide (35.3 ± 6.4 vs. 39.4 ± 7.8, P = 0.013) and bicarbonate levels (19.3 ± 2.7 vs. 21.6 ± 5.3, P = 0.019) but higher oxygen levels (34 ± 6 vs. 22 ± 4, P < 0.001). Apgar scores were higher in Group A at 1 minute (median = 9 vs. 8, P = 0.023), 10 minutes (median = 10 vs. 9, P < 0.001), and 20 minutes. Group A neonates also had significantly higher oxygen levels at 1, 3, 5, and 10 minutes post-delivery but there was no statistically significant difference in admission rate. Conclusion: Maternal oxygenation during elective cesarean sections may positively influences neonatal outcomes, as evidenced by improved Apgar scores and higher neonatal oxygen levels but no effect on admission rate.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"26 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141273074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.21608/bmfj.2024.240523.1912
N. Abo-Elmaety, Neveen A. Kohaf, Hany Bauiomy, Ahmed M. Abosakaya
: Background: Postdural puncture headache (PDPH) commonly arises following a lumbar puncture. It is typically managed through conservative measures or an epidural blood patch (EBP), but each has limitations. This trial aimed to compare the efficacy and safety of pregabalin versus EBP in the management of PDPH. Methods: This randomized controlled trial was conducted on 75 cases with confirmed diagnosis of PDPH. Patients were equally randomized into three groups: Group A (pregabalin group) received oral pregabalin treatment administered at 150 mg daily, with 75 mg given every 12 hours. Group B (EBP group) received EBP and Group C (control group) received conservative treatment. Results: Complete relief of headache was experienced by 13 (52%) patients in group A, 18 (72%) patients in group B, and 5 (20%) patients in group C, with significant distinctions observed among the examined groups (P<0.001). The VAS scores, severity of headache, and frequency of attacks demonstrated a significant improvement at 12h, 24h,36h, and 48h post-treatment within all groups A, B, and C (P<0.001) compared to baseline. Group A was comparable at most time points during follow-up with EBP and better than conservative treatment in terms of VAS scores, severity of headache and frequency of attacks. Conclusions: Pregabalin was comparable at most time points during follow-up with EBP and better than conservative treatment in terms of pain, impact on daily activities and frequency of attacks. Being a non-invasive route, oral pregabalin showed lower back pain than EBP, making it a promising drug for the management of PDPH.
{"title":"Pregabalin as Alternative to Epidural Blood Patch in Treatment of Postdural Puncture Headache: A Randomized Controlled Clinical Trial","authors":"N. Abo-Elmaety, Neveen A. Kohaf, Hany Bauiomy, Ahmed M. Abosakaya","doi":"10.21608/bmfj.2024.240523.1912","DOIUrl":"https://doi.org/10.21608/bmfj.2024.240523.1912","url":null,"abstract":": Background: Postdural puncture headache (PDPH) commonly arises following a lumbar puncture. It is typically managed through conservative measures or an epidural blood patch (EBP), but each has limitations. This trial aimed to compare the efficacy and safety of pregabalin versus EBP in the management of PDPH. Methods: This randomized controlled trial was conducted on 75 cases with confirmed diagnosis of PDPH. Patients were equally randomized into three groups: Group A (pregabalin group) received oral pregabalin treatment administered at 150 mg daily, with 75 mg given every 12 hours. Group B (EBP group) received EBP and Group C (control group) received conservative treatment. Results: Complete relief of headache was experienced by 13 (52%) patients in group A, 18 (72%) patients in group B, and 5 (20%) patients in group C, with significant distinctions observed among the examined groups (P<0.001). The VAS scores, severity of headache, and frequency of attacks demonstrated a significant improvement at 12h, 24h,36h, and 48h post-treatment within all groups A, B, and C (P<0.001) compared to baseline. Group A was comparable at most time points during follow-up with EBP and better than conservative treatment in terms of VAS scores, severity of headache and frequency of attacks. Conclusions: Pregabalin was comparable at most time points during follow-up with EBP and better than conservative treatment in terms of pain, impact on daily activities and frequency of attacks. Being a non-invasive route, oral pregabalin showed lower back pain than EBP, making it a promising drug for the management of PDPH.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"50 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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