Pub Date : 2024-03-22DOI: 10.21608/bmfj.2024.265732.2005
Hatem Abd Elsalam, Nabil Elorabi, Elham Elassas, Yousef Abdel Zaher
Background: Intraoperative hemorrhage remains a major concern of surgery in obstetrics and gynecology. Morbidity can be severe, resulting in increased transfusion rates, hospital stay, cost and rarely mortality. Aim of the Work: the study aims to assess the efficacy and safety of topical hemostatic agents in different causes of bleeding in obstetrics and gynecology as post-partum hemorrhage, myomectomy, and ectopic pregnancy. Patients & Methods: This study was carried out on 60 female patients divided into 2 groups. Group 1: Patients with PPH, myomectomy operation, and ectopic, who have bleeding during surgery who and given the usual management protocol of a university hospital plus the use of a THA (gel foam) Group 2: Patients with PPH, myomectomy operation, and ectopic and given the usual management protocol. Results : Those technically simple procedures such as the use of Gel foam at the bleeding sites should have priority in cases of PPH, Myomectomy and Ectopic pregnancy because they are effective, reliable, and can be performed under easy instructions and by less trained personnel. In this study, Hemoglobin level was much greater in group A than in group B, per post-operative data (p-value = 0.05). Conclusion: The study's findings, imply that topical hemostatic agents would help to treat intraoperative bleeding in patients who have had myomectomy, ectopic pregnancy, or postpartum hemorrhage. When compared to the standard code red management procedure alone.
{"title":"Evaluation of Efficacy and Safety of Topical Hemostatic Agents in controlling Obstetric and Gynecologic Hemorrhage","authors":"Hatem Abd Elsalam, Nabil Elorabi, Elham Elassas, Yousef Abdel Zaher","doi":"10.21608/bmfj.2024.265732.2005","DOIUrl":"https://doi.org/10.21608/bmfj.2024.265732.2005","url":null,"abstract":"Background: Intraoperative hemorrhage remains a major concern of surgery in obstetrics and gynecology. Morbidity can be severe, resulting in increased transfusion rates, hospital stay, cost and rarely mortality. Aim of the Work: the study aims to assess the efficacy and safety of topical hemostatic agents in different causes of bleeding in obstetrics and gynecology as post-partum hemorrhage, myomectomy, and ectopic pregnancy. Patients & Methods: This study was carried out on 60 female patients divided into 2 groups. Group 1: Patients with PPH, myomectomy operation, and ectopic, who have bleeding during surgery who and given the usual management protocol of a university hospital plus the use of a THA (gel foam) Group 2: Patients with PPH, myomectomy operation, and ectopic and given the usual management protocol. Results : Those technically simple procedures such as the use of Gel foam at the bleeding sites should have priority in cases of PPH, Myomectomy and Ectopic pregnancy because they are effective, reliable, and can be performed under easy instructions and by less trained personnel. In this study, Hemoglobin level was much greater in group A than in group B, per post-operative data (p-value = 0.05). Conclusion: The study's findings, imply that topical hemostatic agents would help to treat intraoperative bleeding in patients who have had myomectomy, ectopic pregnancy, or postpartum hemorrhage. When compared to the standard code red management procedure alone.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140387851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-21DOI: 10.21608/bmfj.2024.262158.1993
Tamer I. Salem, Nermin A. Alashker, Husam M. Faramawi
Background: Central retinal vein occlusion (CRVO) is the second most common retinal vascular disorder next to diabetic retinopathy. This study aimed to study the optical coherence tomography angiography (OCTA) findings in patients with central retinal vein occlusion (CRVO) and their relationship to the best correct visual acuity (BCVA) at presentation. Subject and Methods: A total of 40 cases with CRVO were evaluated. Patients were grouped into 2 groups according to BCVA at presentation, group I with BCVA ≤ of 1.0 logMAR and group II with BCVA > 1.0 logMAR. OCTA studies were performed after resolution of the cystoid macular edema (CME) following a serial of intravitreal anti vascular endothelial growth factors (VEGF) injections to ensure reliability of the data. OCTA findings were recorded and correlated to BCVA. Result: Regarding FAZ diameter it was significantly larger in cases with BCVA > 1.0 LogMAR (0.71) than study group with BCVA ≤ 1.0 LogMAR (0.39) (P<0.001). Regarding SVD, SFVD, SPFVD, DVD, DFVD, DPFVD, it was significantly lower in study group with BCVA > 1.0 than study group with BCVA ≤ 1.0. Conclusion: OCTA is a fast, noninvasive, and effective examination for CRVO that can display the vascular density and the FAZ area quantitatively and distinctly. An enlarged FAZ area and disruption of the foveal avascular zone correlated significantly with poorer visual outcomes.
{"title":"Correlations between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Central Retinal Vein Occlusion","authors":"Tamer I. Salem, Nermin A. Alashker, Husam M. Faramawi","doi":"10.21608/bmfj.2024.262158.1993","DOIUrl":"https://doi.org/10.21608/bmfj.2024.262158.1993","url":null,"abstract":"Background: Central retinal vein occlusion (CRVO) is the second most common retinal vascular disorder next to diabetic retinopathy. This study aimed to study the optical coherence tomography angiography (OCTA) findings in patients with central retinal vein occlusion (CRVO) and their relationship to the best correct visual acuity (BCVA) at presentation. Subject and Methods: A total of 40 cases with CRVO were evaluated. Patients were grouped into 2 groups according to BCVA at presentation, group I with BCVA ≤ of 1.0 logMAR and group II with BCVA > 1.0 logMAR. OCTA studies were performed after resolution of the cystoid macular edema (CME) following a serial of intravitreal anti vascular endothelial growth factors (VEGF) injections to ensure reliability of the data. OCTA findings were recorded and correlated to BCVA. Result: Regarding FAZ diameter it was significantly larger in cases with BCVA > 1.0 LogMAR (0.71) than study group with BCVA ≤ 1.0 LogMAR (0.39) (P<0.001). Regarding SVD, SFVD, SPFVD, DVD, DFVD, DPFVD, it was significantly lower in study group with BCVA > 1.0 than study group with BCVA ≤ 1.0. Conclusion: OCTA is a fast, noninvasive, and effective examination for CRVO that can display the vascular density and the FAZ area quantitatively and distinctly. An enlarged FAZ area and disruption of the foveal avascular zone correlated significantly with poorer visual outcomes.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-21DOI: 10.21608/bmfj.2024.256431.1990
M. Ellaban, Sherine Ahmed
Background : Post acne erythema is a common complication of acne with no gold standard treatment . Unfortunately, complete clearance of acne erythema may not always be achieved, therefore it is a therapeutic challenge. Aim : To compare the efficacy of Q-switched 1064 nm Nd:YAG laser when combined with topical OXZ on the right half and topical TXA on the left half for PAE. Methods : A controlled trial was conducted with 30 patients having PAE recruited from the outpatient clinic of Dermatology, department of Benha University Hospitals. All patients were subjected to Q switched Nd:YAG laser followed by topical treatment using split face model: OXZ on the right half and TXA on the left one. This regimen was repeated three times at a 2-weeks interval. Outcomes were assessed by digital photography. Results : The count and the grade of PAE on the two sides of the face were significantly improved after the end of both treatments compared to the baseline. Pain, and erythema were the most frequently reported adverse effects. Conclusion : A new effective combination of Q-switched 1064 nm Nd:YAG laser with topical vasoconstrictors regimen either TXA or OXZ has a promising role in PAE treatment with fewer side effects for PAE.
{"title":"Comparison of The Efficacy of Topical Tranexamic Acid and Oxymetazoline Following Q-Switched 1064 Nm Nd: YAG Laser for The Treatment of Post Acne Erythema: A Split-Face, Controlled Trial","authors":"M. Ellaban, Sherine Ahmed","doi":"10.21608/bmfj.2024.256431.1990","DOIUrl":"https://doi.org/10.21608/bmfj.2024.256431.1990","url":null,"abstract":"Background : Post acne erythema is a common complication of acne with no gold standard treatment . Unfortunately, complete clearance of acne erythema may not always be achieved, therefore it is a therapeutic challenge. Aim : To compare the efficacy of Q-switched 1064 nm Nd:YAG laser when combined with topical OXZ on the right half and topical TXA on the left half for PAE. Methods : A controlled trial was conducted with 30 patients having PAE recruited from the outpatient clinic of Dermatology, department of Benha University Hospitals. All patients were subjected to Q switched Nd:YAG laser followed by topical treatment using split face model: OXZ on the right half and TXA on the left one. This regimen was repeated three times at a 2-weeks interval. Outcomes were assessed by digital photography. Results : The count and the grade of PAE on the two sides of the face were significantly improved after the end of both treatments compared to the baseline. Pain, and erythema were the most frequently reported adverse effects. Conclusion : A new effective combination of Q-switched 1064 nm Nd:YAG laser with topical vasoconstrictors regimen either TXA or OXZ has a promising role in PAE treatment with fewer side effects for PAE.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Patients with Type 2 Diabetes Mellitus (T2DM) facing non-ST-Segment Elevation Myocardial Infarction (NSTEMI) often exhibit a higher incidence of thrombotic events. Hemoglobin A1c (HbA1c) levels, indicative of glycemic control, might influence the thrombus burden in such cases. This study aimed to evaluate the relationship between HbA1c, and coronary thrombus burden expressed as thrombolysis in Myocardial Infarction (TIMI) thrombus grade, in NSTEMI patients. Methods: This cross-sectional comparative study was carried out on NSTEMI patients with T2DM who underwent early percutaneous coronary angiography. Patients were categorized into two groups based on HbA1c levels: Group I (optimal glycemic control, HbA1c ≤ 6.5%) and group II (suboptimal glycemic control, HbA1c > 6.5%). Detailed clinical, laboratory, and angiographic assessments were performed. The primary outcome measure was the TIMI thrombus grade. Results : Group II showed significantly higher weight compared to group I (p= 0.026). Group II exhibited higher fasting blood glucose (FBG) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels (p< 0.001). Echocardiographic parameters demonstrated a significantly lower Mitral E in group II (p< 0.001). Angiographic parameters revealed a significant difference in the infarct-related artery (p= 0.026), with higher TIMI thrombus grade scores and Syntax scores in group II (p< 0.001). Revascularization selection varied significantly between groups (p= 0.038). Conclusion: Elevated HbA1c levels in NSTEMI patients with T2DM were associated with increased thrombus burden, as indicated by higher TIMI thrombus grades.
{"title":"Hemoglobin A1c levels and thrombus load in patients with type 2 diabetes mellitus and non-ST-segment elevation myocardial infarction","authors":"Mohamed Ali, Hesham Khaled Rashid, Afnan Abdel Aal, shereen farag","doi":"10.21608/bmfj.2024.257828.1984","DOIUrl":"https://doi.org/10.21608/bmfj.2024.257828.1984","url":null,"abstract":"Background: Patients with Type 2 Diabetes Mellitus (T2DM) facing non-ST-Segment Elevation Myocardial Infarction (NSTEMI) often exhibit a higher incidence of thrombotic events. Hemoglobin A1c (HbA1c) levels, indicative of glycemic control, might influence the thrombus burden in such cases. This study aimed to evaluate the relationship between HbA1c, and coronary thrombus burden expressed as thrombolysis in Myocardial Infarction (TIMI) thrombus grade, in NSTEMI patients. Methods: This cross-sectional comparative study was carried out on NSTEMI patients with T2DM who underwent early percutaneous coronary angiography. Patients were categorized into two groups based on HbA1c levels: Group I (optimal glycemic control, HbA1c ≤ 6.5%) and group II (suboptimal glycemic control, HbA1c > 6.5%). Detailed clinical, laboratory, and angiographic assessments were performed. The primary outcome measure was the TIMI thrombus grade. Results : Group II showed significantly higher weight compared to group I (p= 0.026). Group II exhibited higher fasting blood glucose (FBG) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) levels (p< 0.001). Echocardiographic parameters demonstrated a significantly lower Mitral E in group II (p< 0.001). Angiographic parameters revealed a significant difference in the infarct-related artery (p= 0.026), with higher TIMI thrombus grade scores and Syntax scores in group II (p< 0.001). Revascularization selection varied significantly between groups (p= 0.038). Conclusion: Elevated HbA1c levels in NSTEMI patients with T2DM were associated with increased thrombus burden, as indicated by higher TIMI thrombus grades.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-18DOI: 10.21608/bmfj.2024.243200.1926
Amal Idris, Sania Elwia, Yasmin Marei, Ahmed Bendary, Moamena Mahmoud
: Background: Venous thromboembolism (VTE) is a common and potentially lethal disorder that manifests mainly as deep vein thrombosis (DVT) of the extremities or pulmonary embolism (PE) and occurs because of genetic and environmental risk factors. Aim of the study: To evaluate the genetic markers Factor V Leiden (G1691A), Prothrombin gene (PT G20210) and methylene tetra hydro folate reductase (MTHFR C677T) polymorphisms in high-risk patients with venous thromboembolism in Benha University Hospital. Patients and Methods: The study consisted of 20 patients of both sexes divided into three groups lower limb DVT group, isolated PE group and DVT complicated by PE group. A venous blood sample collected from patients was used to detect Factor V Leiden (G1691A), Prothrombin gene (G20210A) and methylene tetra hydro folate reductase (MTHFR C677T) polymorphisms by real time polymerase chain reaction (PCR) genotyping. Results: We found that the highest genotyping frequency was FVL G1691A polymorphism found in 8 patients (72.7.0%) of included patients with thrombophilic gene polymorphisms, the lowest frequency was F2 G20210A polymorphism found in 2 patients (18.0%) and 5 patients (45%) had MTHFRC677T polymorphism of included patients with thrombophilic gene polymorphisms. FVL G1691A had the highest percentage of 3 patients (25.0%) in lower limb DVT group then MTHFRC677T 2 patients (16.7%) and the lowest percentage was prothrombin G20210A one patient (8.3%). FVL G1691A and MTHFRC677T had an equal percentage in pulmonary thromboembolism group, 2 patients (40.0%) having each polymorphism which is higher than prothrombin G20210A (0.0%) that wasn’t detected in this group. FVL G1691A had the highest percentage, 3 patients (100.0) in DVT and pulmonary embolism group while prothrombin G20210A and MTHFRC677T had an equal percentage, one patient (33.3%) having each polymorphism. The genotyping frequency of these polymorphisms had no statistically significant difference between VTE subgroups. Conclusion: The present study performed a review of genetic variants associated with venous thromboembolism for understanding the underlying etiology and our results give a strategy of diagnostic evaluations for the individuals at high risk of venous thromboembolism.
{"title":"Study of prevalence of thrombophilic genes (FVL G1691A, prothrombin G20210A and MTHFR C677T) polymorphisms in patients with venous thromboembolism in Benha university hospital; cross sectional study.","authors":"Amal Idris, Sania Elwia, Yasmin Marei, Ahmed Bendary, Moamena Mahmoud","doi":"10.21608/bmfj.2024.243200.1926","DOIUrl":"https://doi.org/10.21608/bmfj.2024.243200.1926","url":null,"abstract":": Background: Venous thromboembolism (VTE) is a common and potentially lethal disorder that manifests mainly as deep vein thrombosis (DVT) of the extremities or pulmonary embolism (PE) and occurs because of genetic and environmental risk factors. Aim of the study: To evaluate the genetic markers Factor V Leiden (G1691A), Prothrombin gene (PT G20210) and methylene tetra hydro folate reductase (MTHFR C677T) polymorphisms in high-risk patients with venous thromboembolism in Benha University Hospital. Patients and Methods: The study consisted of 20 patients of both sexes divided into three groups lower limb DVT group, isolated PE group and DVT complicated by PE group. A venous blood sample collected from patients was used to detect Factor V Leiden (G1691A), Prothrombin gene (G20210A) and methylene tetra hydro folate reductase (MTHFR C677T) polymorphisms by real time polymerase chain reaction (PCR) genotyping. Results: We found that the highest genotyping frequency was FVL G1691A polymorphism found in 8 patients (72.7.0%) of included patients with thrombophilic gene polymorphisms, the lowest frequency was F2 G20210A polymorphism found in 2 patients (18.0%) and 5 patients (45%) had MTHFRC677T polymorphism of included patients with thrombophilic gene polymorphisms. FVL G1691A had the highest percentage of 3 patients (25.0%) in lower limb DVT group then MTHFRC677T 2 patients (16.7%) and the lowest percentage was prothrombin G20210A one patient (8.3%). FVL G1691A and MTHFRC677T had an equal percentage in pulmonary thromboembolism group, 2 patients (40.0%) having each polymorphism which is higher than prothrombin G20210A (0.0%) that wasn’t detected in this group. FVL G1691A had the highest percentage, 3 patients (100.0) in DVT and pulmonary embolism group while prothrombin G20210A and MTHFRC677T had an equal percentage, one patient (33.3%) having each polymorphism. The genotyping frequency of these polymorphisms had no statistically significant difference between VTE subgroups. Conclusion: The present study performed a review of genetic variants associated with venous thromboembolism for understanding the underlying etiology and our results give a strategy of diagnostic evaluations for the individuals at high risk of venous thromboembolism.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140390173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-18DOI: 10.21608/bmfj.2024.216972.1838
Fatma Abd-El-Fatah, Ahmed Abd El-Hamid, Abeer Soliman Emara, Emad Rezk
: Background: systemic corticosteroids have demonstrated definite mortality benefit in management of COVID 19 in various studies. Still certain questions regarding the appropriate dose, duration and timing of corticosteroids remain unanswered. For this reason, the study was planned to determine the efficacy and safety of methyl prednisolone in management of COVID 19 from publicly available evidence. Objectives: To compare between dexamethasone and methylprednisolone in treating Covid-19 pneumonia patients with respiratory failure. Study design: Meta-analysis was used to address this concern. Sittings: Meta-analysis-based study following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta Analyses) guidelines. Methods: Online databases (PubMed, Embase, BioMed, and the Cochrane Central Register of Controlled trials) were used for randomized studies ever performed in humans in any clinical setting. Results: Ten studies were identified for inclusion in this study, involving a total of 1812 patients. The risk of bias was low. Meta-analysis found that methylprednisolone result in significant decrease in hospital length of stay, ventilatory need and mortality. Conclusion: Our meta-analysis found that methylprednisolone has the potential to improve the prognosis of patients with severe COVID-19 pneumonia, in comparison to dexamethasone.
:背景：在多项研究中，全身使用皮质类固醇对治疗 COVID 19 有明确的死亡率益处。但有关皮质类固醇的适当剂量、持续时间和时机的某些问题仍未得到解答。因此，本研究计划从现有的公开证据中确定甲基泼尼松龙治疗 COVID 19 的疗效和安全性。研究目的比较地塞米松和甲基强的松龙在治疗伴有呼吸衰竭的 COVID-19 肺炎患者中的疗效。研究设计：采用 Meta 分析来解决这一问题。坐位：基于 Meta 分析的研究，遵循 PRISMA（系统综述和 Meta 分析首选报告项目）指南。研究方法使用在线数据库（PubMed、Embase、BioMed 和 Cochrane Central Register of Controlled trials）检索在任何临床环境中对人类进行的随机研究。结果本研究共确定了 10 项研究，涉及 1812 名患者。偏倚风险较低。Meta 分析发现，甲基强的松龙可显著减少住院时间、呼吸机需求和死亡率。结论：我们的荟萃分析发现，与地塞米松相比，甲基强的松龙有可能改善重症 COVID-19 肺炎患者的预后。
{"title":"Dexamethasone Vs methylprednisolone In treating Covid-19 pneumonia: A meta-analysis of randomized trials","authors":"Fatma Abd-El-Fatah, Ahmed Abd El-Hamid, Abeer Soliman Emara, Emad Rezk","doi":"10.21608/bmfj.2024.216972.1838","DOIUrl":"https://doi.org/10.21608/bmfj.2024.216972.1838","url":null,"abstract":": Background: systemic corticosteroids have demonstrated definite mortality benefit in management of COVID 19 in various studies. Still certain questions regarding the appropriate dose, duration and timing of corticosteroids remain unanswered. For this reason, the study was planned to determine the efficacy and safety of methyl prednisolone in management of COVID 19 from publicly available evidence. Objectives: To compare between dexamethasone and methylprednisolone in treating Covid-19 pneumonia patients with respiratory failure. Study design: Meta-analysis was used to address this concern. Sittings: Meta-analysis-based study following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta Analyses) guidelines. Methods: Online databases (PubMed, Embase, BioMed, and the Cochrane Central Register of Controlled trials) were used for randomized studies ever performed in humans in any clinical setting. Results: Ten studies were identified for inclusion in this study, involving a total of 1812 patients. The risk of bias was low. Meta-analysis found that methylprednisolone result in significant decrease in hospital length of stay, ventilatory need and mortality. Conclusion: Our meta-analysis found that methylprednisolone has the potential to improve the prognosis of patients with severe COVID-19 pneumonia, in comparison to dexamethasone.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140390537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.21608/bmfj.2024.237805.1906
Y.S. Edris, Nabil Eldeen, Mahmoud Abd Elmoghney, Waleed Tawfik
: Background: Postpartum hemorrhage (PPH) remains a leading cause of maternal morbidity and mortality, particularly in high-risk pregnant patients. The early prediction and effective management of PPH are crucial to improving maternal outcomes. Serum fibrinogen levels have emerged as a potential biomarker for predicting and managing PPH. The aim is to study the role of serum fibrinogen level in prediction and anticipation of postpartum hemorrhage and its role in the treatment. Methods: This cross-sectional observational study was carried out on pregnant females at high risk of PPH attending Benha University Hospital and Toukh Central Hospital over a six-month period. Detailed clinical assessments, laboratory investigations, and obstetric monitoring were conducted. Serum fibrinogen levels were measured using quantitative analysis. Antenatal and intrapartum care were tailored to patient needs. PPH cases received treatment with fibrinogen concentrate, cryoprecipitate, or fresh frozen plasma as indicated. Results: According to serum fibrinogen levels, the mean serum fibrinogen level of the studied cases was 3.6 (±1.15) g/l. There was high statistically significant relation between bleeding severity and serum fibrinogen. According to ROC curve analysis for the use of serum fibrinogen levels to predict severity of bleeding, using serum fibrinogen levels at 3.95, it can predict PPH with 0.859 AUC, sensitivity 100%, specificity 71.9%, PPV 66.7%, NPV 100% and accuracy 82.0%. Conclusion: Serum fibrinogen levels show promise as a valuable predictor for PPH in high-risk pregnant patients. Monitoring fibrinogen levels could aid in early identification and timely intervention, potentially reducing the severity and complications of PPH.
{"title":"Use of Fibrinogen in Prevention and Management of Postpartum Haemorrhage in High Risk Patient","authors":"Y.S. Edris, Nabil Eldeen, Mahmoud Abd Elmoghney, Waleed Tawfik","doi":"10.21608/bmfj.2024.237805.1906","DOIUrl":"https://doi.org/10.21608/bmfj.2024.237805.1906","url":null,"abstract":": Background: Postpartum hemorrhage (PPH) remains a leading cause of maternal morbidity and mortality, particularly in high-risk pregnant patients. The early prediction and effective management of PPH are crucial to improving maternal outcomes. Serum fibrinogen levels have emerged as a potential biomarker for predicting and managing PPH. The aim is to study the role of serum fibrinogen level in prediction and anticipation of postpartum hemorrhage and its role in the treatment. Methods: This cross-sectional observational study was carried out on pregnant females at high risk of PPH attending Benha University Hospital and Toukh Central Hospital over a six-month period. Detailed clinical assessments, laboratory investigations, and obstetric monitoring were conducted. Serum fibrinogen levels were measured using quantitative analysis. Antenatal and intrapartum care were tailored to patient needs. PPH cases received treatment with fibrinogen concentrate, cryoprecipitate, or fresh frozen plasma as indicated. Results: According to serum fibrinogen levels, the mean serum fibrinogen level of the studied cases was 3.6 (±1.15) g/l. There was high statistically significant relation between bleeding severity and serum fibrinogen. According to ROC curve analysis for the use of serum fibrinogen levels to predict severity of bleeding, using serum fibrinogen levels at 3.95, it can predict PPH with 0.859 AUC, sensitivity 100%, specificity 71.9%, PPV 66.7%, NPV 100% and accuracy 82.0%. Conclusion: Serum fibrinogen levels show promise as a valuable predictor for PPH in high-risk pregnant patients. Monitoring fibrinogen levels could aid in early identification and timely intervention, potentially reducing the severity and complications of PPH.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Background: Cardiac troponin T (cTnT) has been proposed as specific biochemical marker for myocardial infarction in adults. Cardiac function in neonates could be influenced by the severity of respiratory distress (RD) and its ventilatory management. Aim of the study was to investigate cTnT levels in neonates with respiratory distress as a marker of myocardial dysfunction Methods: Total sample size 100 neonate, 50 neonates with RD and 50 healthy neonates (without RD). Concentrations of cTnT were compared between sick and healthy infants, Age at sampling, need for ventilation, duration of respiratory support, and inotropic use in addition to neonatal and maternal characteristics. Results: CTnT levels were significantly higher (p<0.001) in study group (RD cases) (0.200±0.156 ng/ml) than in control group (healthy neonates) (0.034±0.019 ng/ml). Area under the ROC curve was 0.962 with best cutoff value (>0.056), sensitivity was 90%, specificity was 90%. Also, cTnT levels were significantly higher in neonates who required inotropic support when compared to those without inotropes. We found CTnT levels were significantly higher in cases who died than in cases who survived (p<0.001). Conclusion: Cardiac troponin T could be used as a useful marker for myocardial dysfunction in neonates with respiratory distress
{"title":"Level of cardiac troponin T in relation to disease severity and outcomes in neonates with respiratory distress","authors":"Effat Assar, Shaheen Yasin Dabour, Yasser Ismail, sarah sanad, Rasha Hassan","doi":"10.21608/bmfj.2024.234387.1891","DOIUrl":"https://doi.org/10.21608/bmfj.2024.234387.1891","url":null,"abstract":": Background: Cardiac troponin T (cTnT) has been proposed as specific biochemical marker for myocardial infarction in adults. Cardiac function in neonates could be influenced by the severity of respiratory distress (RD) and its ventilatory management. Aim of the study was to investigate cTnT levels in neonates with respiratory distress as a marker of myocardial dysfunction Methods: Total sample size 100 neonate, 50 neonates with RD and 50 healthy neonates (without RD). Concentrations of cTnT were compared between sick and healthy infants, Age at sampling, need for ventilation, duration of respiratory support, and inotropic use in addition to neonatal and maternal characteristics. Results: CTnT levels were significantly higher (p<0.001) in study group (RD cases) (0.200±0.156 ng/ml) than in control group (healthy neonates) (0.034±0.019 ng/ml). Area under the ROC curve was 0.962 with best cutoff value (>0.056), sensitivity was 90%, specificity was 90%. Also, cTnT levels were significantly higher in neonates who required inotropic support when compared to those without inotropes. We found CTnT levels were significantly higher in cases who died than in cases who survived (p<0.001). Conclusion: Cardiac troponin T could be used as a useful marker for myocardial dysfunction in neonates with respiratory distress","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":" 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-12DOI: 10.21608/bmfj.2024.262322.1994
Mohamed Metwally, Hussein Okasha, Ahmed Elgazar, Ahmed Mostafa Mahmoud Mira
Background: Diseases of the gallbladder are relatively common, and the most common pathology ischolelithiasis, affecting 10 – 15 % of the population . Aim and objectives: To study the detection rate of gallbladder diseases by Endoscopic Ultrasound (EUS) in comparison to Trans abdominal Ultrasound (TAUS). Patient and methods: This was a prospective cross sectional study conducted on 100 patients fulfilling the inclusion criteria in Maadi Military Hospital. All the data were collected after ethical approval. Results: According to indication of EUS there were 19 (19%) patients had pancreatic mass, 55 (55%) patients had abdominal pain, 8 (8%) patients had pancreatitis, 12 (12%) patients had obstructive jaundice, 4 (4%) patients had pancreatic cyst, and 2 (2%) patients had a follow up cancer. Our results showed that there was a significant relationship between EUS and trans-abdominal US findings (P value <0.001). Also, our results showed that there was a significant moderate agreement between EUS and trans-abdominal US findings (k= 0.491, P value <0.001). Conclusion: Endoscopic Ultrasound (EUS) is a valuable tool for detecting gallbladder diseases; it has potential superiority over TAUS in diagnosing gallbladder diseases, especially when a detailed assessment is crucial.
背景：胆囊疾病比较常见，其中最常见的病变是胆石症，发病率占总人口的10%-15%。目的和目标研究内镜超声（EUS）与经腹超声（TAUS）对胆囊疾病的检出率。患者和方法：这是一项前瞻性横断面研究，研究对象是马阿迪军医院 100 名符合纳入标准的患者。所有数据均在获得伦理批准后收集。研究结果根据 EUS 的适应症，19（19%）名患者有胰腺肿块，55（55%）名患者有腹痛，8（8%）名患者有胰腺炎，12（12%）名患者有阻塞性黄疸，4（4%）名患者有胰腺囊肿，2（2%）名患者有后续癌症。我们的结果显示，EUS 和经腹 US 检查结果之间存在显著关系（P 值<0.001）。此外，我们的结果还显示，EUS 和经腹 US 检查结果之间存在明显的中度一致性（k= 0.491，P 值<0.001）。结论内镜超声（EUS）是检测胆囊疾病的重要工具；在诊断胆囊疾病方面，EUS可能比TAUS更有优势，尤其是在需要进行详细评估时。
{"title":"Role of Endoscopic Ultrasound in Detection of Gallbladder Diseases","authors":"Mohamed Metwally, Hussein Okasha, Ahmed Elgazar, Ahmed Mostafa Mahmoud Mira","doi":"10.21608/bmfj.2024.262322.1994","DOIUrl":"https://doi.org/10.21608/bmfj.2024.262322.1994","url":null,"abstract":"Background: Diseases of the gallbladder are relatively common, and the most common pathology ischolelithiasis, affecting 10 – 15 % of the population . Aim and objectives: To study the detection rate of gallbladder diseases by Endoscopic Ultrasound (EUS) in comparison to Trans abdominal Ultrasound (TAUS). Patient and methods: This was a prospective cross sectional study conducted on 100 patients fulfilling the inclusion criteria in Maadi Military Hospital. All the data were collected after ethical approval. Results: According to indication of EUS there were 19 (19%) patients had pancreatic mass, 55 (55%) patients had abdominal pain, 8 (8%) patients had pancreatitis, 12 (12%) patients had obstructive jaundice, 4 (4%) patients had pancreatic cyst, and 2 (2%) patients had a follow up cancer. Our results showed that there was a significant relationship between EUS and trans-abdominal US findings (P value <0.001). Also, our results showed that there was a significant moderate agreement between EUS and trans-abdominal US findings (k= 0.491, P value <0.001). Conclusion: Endoscopic Ultrasound (EUS) is a valuable tool for detecting gallbladder diseases; it has potential superiority over TAUS in diagnosing gallbladder diseases, especially when a detailed assessment is crucial.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140394691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-12DOI: 10.21608/bmfj.2024.253652.1974
Naslshah G Kazem, Ahmed Abdallah Ali Elaskarany, Hossam Eldin Abdelazim
Background: Chronic rhinosinusitis (CRS) is a sinonasal mucosa inflammation. It's categorised by polyp status. But data implies that chronic rhinosinusitis without nasal polyps (CRSsNP) and CRSwNP are discrete disease entities with distinct inflammatory milieu. The aim of the study: to evaluate the impact of vitamin D supplementation (4000 IU/day) on the risk of nasal polyp recurrence in CRSwNP individuals who have had functional endoscopic sinus surgery (FESS). Methods : This randomized triple-blinded controlled research was performed on thirty cases presented in Outpatient Clinic of Benha University Hospitals with CRS during the study period of 6 months. The study duration was from September 2022 until March 2023. Result: there was a significant variation among the examined groups concerning Six months follow up Meltzer scores, six months follow up SNOT-22 scores and Nasal polyp recurrence. there was no significant distinction among the investigated groups as concern Demographic characteristics, Serum Vit.D level results, Preoperative Meltzer scores and Preoperative SNOT-22 scores. Conclusion: The current investigation demonstrated the effectiveness and safety of vitamin D supplementation in preventing the recurrence of polyposis in individuals with CRSwNP who had endoscopic sinus surgery. This is the first randomized, triple-blind, placebo-controlled research to examine the effects of VD3 on reducing the recurrence rate of nasal polyposis after endoscopic sinus surgery.
{"title":"Comparative Study of Recurrence of Allergic Nasal Polyposis After Administration of Vitamin D Supplementation","authors":"Naslshah G Kazem, Ahmed Abdallah Ali Elaskarany, Hossam Eldin Abdelazim","doi":"10.21608/bmfj.2024.253652.1974","DOIUrl":"https://doi.org/10.21608/bmfj.2024.253652.1974","url":null,"abstract":"Background: Chronic rhinosinusitis (CRS) is a sinonasal mucosa inflammation. It's categorised by polyp status. But data implies that chronic rhinosinusitis without nasal polyps (CRSsNP) and CRSwNP are discrete disease entities with distinct inflammatory milieu. The aim of the study: to evaluate the impact of vitamin D supplementation (4000 IU/day) on the risk of nasal polyp recurrence in CRSwNP individuals who have had functional endoscopic sinus surgery (FESS). Methods : This randomized triple-blinded controlled research was performed on thirty cases presented in Outpatient Clinic of Benha University Hospitals with CRS during the study period of 6 months. The study duration was from September 2022 until March 2023. Result: there was a significant variation among the examined groups concerning Six months follow up Meltzer scores, six months follow up SNOT-22 scores and Nasal polyp recurrence. there was no significant distinction among the investigated groups as concern Demographic characteristics, Serum Vit.D level results, Preoperative Meltzer scores and Preoperative SNOT-22 scores. Conclusion: The current investigation demonstrated the effectiveness and safety of vitamin D supplementation in preventing the recurrence of polyposis in individuals with CRSwNP who had endoscopic sinus surgery. This is the first randomized, triple-blind, placebo-controlled research to examine the effects of VD3 on reducing the recurrence rate of nasal polyposis after endoscopic sinus surgery.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"33 S124","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140395083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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