The analysis of changes in bone marrow cell cycle induced by ionising radiation in animals and humans in comparison with myelogram evidence on postradiation death of myelocaryocytes shows that radiation is responsible for pronounced dose-dependent shifts in cell cycle early after radiation prior to postradiation cell death. These phenomena are considered in light of new hypophysis on the existence of cell cycle regulation system and initiation of apoptosis at the cell level.
Rat experiments indicate that chronic gamma-preirradiation in a dose of 90.0 rads (dose rate 3.0 rad/day) inhibits development of adaptive reactions of hematopoietic system throughout resistance of general adaptation syndrome in emotional stress.
White rat experiments have shown that combination of vitamins A, E, C and P diminishes thrombin-induced thrombocytopenia and low platelet aggregation. This is explained by limited activation of free radical processes initiated by thrombin in plasma, red cells and platelets. It was found that thrombin ability to activate lipid peroxidation is not related to coagulatory transformation of fibrinogen, but is rather due to a direct contact of the enzyme with platelets. A protective effect of vitamins-antioxidants in thrombinemia is likely to rest on their ability to restrict activation of free radical oxidation in platelets.
The response of biochemical parameters of coagulation to chemical stimulation of different amygdaloid structures has been studied. It is demonstrated that a microinjection of L-glutamate, a stimulating amino acid, into the above structures induces hypercoagulation. This gives evidence for a direct implication of the amygdala, an essential structure of the limbic system, in the mechanisms controlling central regulation of blood coagulation with probable involvement of direct amygdalospinal tracts.
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