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The Role of Quorum Quenching in Medical Application 定量淬火在医疗应用中的作用
Pub Date : 2024-03-15 DOI: 10.21931/rb/2024.09.01.62
Ghada A. Mohammad, Huda Waleed Hadi
The attempts are continuing in the various fields of life sciences to resolve a big problem, which is the abilityof bacteria to cause pathogenicity for humans, animals, and plants, whether by chemical or biological methodsand in ways that are hoped to be safe. Among these attempts, the control of the Quorum Sensing (QS) mechanism that occurs naturally in bacteria under certain conditions helps to increase the virulence of bacteria,starting from its ability to adhere and form a biofilm. Then, the tissues are invaded with various enzymesaccording to the tissue type, increasing antibiotic resistance. Therefore, the idea came to solve these problemsthrough a mechanism opposite to the Quorum Quenching (QQ), which lies in the investigation of substancesthat can disrupt the QS pathway, whether at the molecular level or the physiological level, as well as benefitingfrom different organisms (Prokaryotes or Eukaryotes) that live in the same environment and produce substances that inhibit bacterial signaling molecules. Lastly, the discovery of varying novel QQ agents from extreme environmental bacteria will be most interesting in the future.Keywords: Quorum sensing, quorum quenching, acyl homoserine lactones, medical application
生命科学的各个领域都在不断尝试解决一个大问题,即细菌对人类、动物和植物的致病能力,无论是通过化学方法还是生物方法,并希望这些方法是安全的。在这些尝试中,控制细菌在特定条件下自然产生的 "法定量感应"(Quorum Sensing,QS)机制有助于增强细菌的致病力,首先是增强其粘附和形成生物膜的能力。然后,细菌会根据组织类型利用各种酶侵入组织,增加抗生素耐药性。因此,人们产生了通过与 "定量淬灭"(QQ)相反的机制来解决这些问题的想法,即研究能在分子水平或生理水平上破坏 QS 途径的物质,并从生活在同一环境中并产生抑制细菌信号分子的物质的不同生物(原核生物或真核生物)中获益。最后,从极端环境细菌中发现不同的新型 QQ 药剂将是未来最有趣的研究方向:法定人数感应、法定人数淬灭、酰基高丝氨酸内酯、医学应用
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引用次数: 0
Genotypic Detection of Carbapenems Resistance Genes in Acinetobacter baumannii Isolated fromUrinary Tract Infection Patients 从泌尿道感染患者中分离出的鲍曼不动杆菌耐碳苯纳西林基因的基因型检测
Pub Date : 2024-03-15 DOI: 10.21931/rb/2024.09.01.60
T. Hayder Hasan, Ameer Sadeq Yasir AL-Ethari, S. Ghani Al-Muhanna, Israa Abdul Ameer Al-Kraety
Acinetobacter baumannii is a Gram-negative bacterium characterized by its short, round, rod-shaped morphology. It is an opportunistic pathogen that poses a significant threat, particularly to immunocompromisedpatients, often those with hospital stays lasting less than 90 days. Between June 2022 and July 2023, 214 urinesamples were collected from individuals suspected of having urinary tract infections (UTIs). These sampleswere subjected to antibiotic resistance testing, focusing on detecting specific genes related to carbapenemresistance, namely blaNDM, blaKPC, and blaVIM.The study's results revealed a notable trend in antibioticresistance among the bacterial isolates. Ceftazidime, cefotaxime, and ceftriaxone, commonly used antibioticsfor UTIs, showed a high resistance rate among the tested isolates. This resistance highlights the challengeshealthcare professionals face when treating UTIs caused by Acinetobacter baumannii. On the other hand, theisolates displayed a comparatively lower resistance rate to imipenem and meropenem, two necessary carbapenem antibiotics. This lower resistance to carbapenems is encouraging as these drugs are often consideredthe last line of defense against multidrug-resistant bacterial infections. The presence of carbapenem resistancegenes, such as blaNDM, blaKPC, and blaVIM, in the Acinetobacter baumannii isolates is of particular concern. These genes confer resistance to carbapenem antibiotics, crucial for treating severe infections caused bymultidrug-resistant bacteria. In conclusion, the study aims to study the growth of antibiotic resistance in Acinetobacter baumannii, especially in urinary tract infections in immunocompromised patients with more extended hospital stays. It also highlights the need for Surveys and periodic examinations to detect the spread ofbacteria and their resistance.Keywords: Carbapenems, UTI, genes, blaNDM, blaKPC, and blaVIM.
鲍曼不动杆菌(Acinetobacter baumannii)是一种革兰氏阴性细菌,其特征是短小、圆形、杆状形态。它是一种机会性病原体,尤其对免疫力低下的患者(通常是住院时间少于 90 天的患者)构成重大威胁。2022 年 6 月至 2023 年 7 月期间,从疑似尿路感染(UTI)患者身上采集了 214 份尿液样本。这些样本接受了抗生素耐药性测试,重点检测与碳青霉烯耐药性有关的特定基因,即 blaNDM、blaKPC 和 blaVIM。头孢他啶、头孢噻肟和头孢曲松是治疗UTI的常用抗生素,但在检测的分离菌株中耐药率很高。这种耐药性凸显了医护人员在治疗鲍曼不动杆菌引起的UTI时所面临的挑战。另一方面,这些分离物对亚胺培南和美罗培南这两种必要的碳青霉烯类抗生素的耐药率相对较低。对碳青霉烯类抗生素的耐药性降低令人鼓舞,因为这类药物通常被认为是抵抗耐多药细菌感染的最后一道防线。鲍曼不动杆菌分离物中出现的碳青霉烯类耐药基因(如 blaNDM、blaKPC 和 blaVIM)尤其令人担忧。这些基因可产生对碳青霉烯类抗生素的耐药性,而碳青霉烯类抗生素是治疗由耐多药细菌引起的严重感染的关键。总之,该研究旨在研究鲍曼不动杆菌耐药性的增长情况,尤其是在住院时间较长的免疫力低下患者的尿路感染中。研究还强调了调查和定期检查的必要性,以检测细菌的传播及其耐药性:碳青霉烯类、UTI、基因、blaNDM、blaKPC 和 blaVIM。
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引用次数: 0
Composición química y evaluación del sinergismo de la actividad antioxidante de mezclas de los aceites esenciales de Luma chequen (Arrayan) y Citrus maxima (Pomelo). Luma chequen(桃金娘)和 Citrus maxima(葡萄柚)精油混合物的化学成分和抗氧化活性协同作用评估。
Pub Date : 2024-03-15 DOI: 10.21931/rb/2024.09.01.63
Carla del Carpio-Jiménez, R. G. Gutierrez-Chavez, H. A. Quispe-Dávil, Ciro Tomaylla-Cruz, Mario J. Urrunaga-Ormachea
Los aceites esenciales son componentes bioactivos usados en áreas como la medicina, la farmacia, la cosmética y la industria alimentaria, se emplean como conservantes por sus propiedades antioxidantes. El objetivode la presente investigación fue extraer, determinar las propiedades fisicoquímicas y cuantificar por cromatografía de gases/espectrometría de masas los principales componentes de los aceites esenciales de Luma chequen y Citrus maxima, así como evaluar la actividad antioxidante de la mezcla de ambos aceites usando elmétodo de inhibición del radical ácido 2,2'-azino-bis-3-etilbenzotiazolina-6-sulfónico (ABTS•+). El rendimiento de extracción fue de 0,82% y de 0,95% para Luma chequen y Citrus maxima respectivamente. El pHfue de 4,5 y 5,5; la densidad fue de 0,877 g/ml y 0,844 g/ml y el índice de refracción fue de 1,4688 y 1,4741respectivamente. Ambos aceites esenciales presentan alto contenido de monoterpenos siendo el α-pineno(57,6%) el más abundante para Luma chequen y el limoneno (30,3%) para Citrus maxima. Respecto a laactividad antioxidante; la inhibición del radical ABTS•+ fue de 49,1% y 93,4% respectivamente, sin embargo,la mezcla constituida por 50% de aceite esencial de Luma chequen y 50% de aceite esencial de Citrus maximapresentó un porcentaje de inhibición de 102.8%, evidenciándose sinergismo.Keywords: Luma chequen, Citrus maxima, antioxidante, monoterpenos, sinergismo
精油是一种生物活性化合物,可用于医学、药学、化妆品和食品工业等领域,并因其抗氧化特性而被用作防腐剂。本研究的目的是提取 Luma chequen 和 Citrus maxima 的精油,确定其理化性质,用气相色谱/质谱法定量分析其主要成分,并用 2,2'-偶氮-双-3-乙基苯并噻唑啉-6-磺酸自由基(ABTS-+)抑制法评估这两种精油混合物的抗氧化活性。Luma chequen 和 Citrus maxima 的提取率分别为 0.82% 和 0.95%。pH 值分别为 4.5 和 5.5,密度分别为 0.877 克/毫升和 0.844 克/毫升,折光率分别为 1.4688 和 1.4741。两种精油的单萜烯含量都很高,其中以 Luma chequen 的 α-蒎烯(57.6%)和 Citrus maxima 的柠檬烯(30.3%)含量最高。在抗氧化活性方面,对 ABTS-+ 自由基的抑制率分别为 49.1%和 93.4%,但由 50%的 Luma chequen 精油和 50%的 Citrus maxima 精油组成的混合物的抑制率为 102.8%,显示出协同作用。
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引用次数: 0
Evaluación del desempeño del cultivo de pepino (Cucumis sativus) frente a tres fertilizantes foliares en la parroquia Nuevo Paraíso, Orellana, Ecuador 厄瓜多尔奥雷利亚纳新帕拉伊索教区黄瓜(Cucumis sativus)作物对三种叶面肥的表现评估。
Pub Date : 2024-03-15 DOI: 10.21931/rb/2024.09.01.11
Lourdes Aguirre-Cobeña, Diego Salguero-Ramos, A. Bonilla-Bonilla, Rodrigo Salazar- López
La producción de pepino en la región amazónica del Ecuador se ha intensificado en los últimos años, debido a las condiciones climáticas idóneas para este cultivo. En la parroquia Nuevo Paraíso, de la provincia de Orellana se siembra el pepino en pequeñas superficies (>1ha) destinado a consumo local. Los productores han visto la necesidad de aumentar sus rendimientos con la aplicación de fertilizantes foliares. El propósito de este estudio fue comparar el desempeño del cultivo de pepino utilizando tres tipos de fertilizantes foliares comerciales con su respectivo análisis económico. La prueba piloto se realizó en un terreno de 1200 m2 donde se aplicaron los fertilizantes Evergreen (2.5 cm/2L), Metalasote (2.5 cm/2L), Agrostemin (1gr) evaluando la altura de planta, número de hojas y flores, diámetro del tallo y características del fruto a los 22, 37 y 49 días y comparándolo con el testigo. Los hallazgos mostraron que Evergreen es una opción rentable con un costo-beneficio de $1,27 y con mejores características de planta y fruto. Este estudio sugiere la aplicación del fertilizante Evergreen en la etapa de crecimiento y floración del cultivo de pepino dado que representa mejores ingresos por hectárea, un mejor costo-beneficio y mayor porcentaje de ganancia respecto a los demás fertilizantes foliares. Palabras clave: Altura de planta; costo-beneficio; Fertilizantes; Pepino; análisis económico
由于气候条件非常适合黄瓜生长,厄瓜多尔亚马逊地区的黄瓜生产近年来得到了加强。在奥雷亚纳省的新帕拉伊索教区,黄瓜种植面积较小(大于 1 公顷),供当地人食用。生产者认为有必要通过施用叶面肥来提高产量。本研究的目的是比较使用三种商用叶面肥的黄瓜作物的表现及其各自的经济分析。试验在一块 1200 平方米的田地里进行,施用 Evergreen(2.5 厘米/2 升)、Metalasote(2.5 厘米/2 升)和 Agrostemin(1 克)肥料,分别在 22 天、37 天和 49 天评估植株高度、叶片和花朵数量、茎杆直径和果实特征,并与对照进行比较。研究结果表明,常青是一种成本效益较高的选择,其成本效益为 1.27 美元,而且植株和果实特征更好。这项研究建议在黄瓜生长和开花期施用常青肥料,因为与其他叶面肥相比,常青肥料的每公顷收益更高,成本效益更好,增产百分比更高。关键词: 植株高度;成本效益;肥料;黄瓜;经济分析。
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引用次数: 0
The Application of Wheat Farmers to Modern Agriculture Technology Related to Improve Crop Production in Thi-Qar 济加尔地区小麦种植者应用现代农业技术提高作物产量的情况
Pub Date : 2024-03-15 DOI: 10.21931/rb/2024.09.01.56
Hakeem, S. Abd. AL.Rekibe
The research aim is to determine the level of application farmers of Modern Agricultural Technology have inimproving wheat crop production in Thi-Qar Province. A multistage sample probability proportionates of size(PPS) was used to conduct this study. The sample number was (75 farmers from the Qalat Sukkar district, 105farmers from the AL-Rifai district, 45 farmers from the AL-Shatrah district, and 29 farmers from the AL-Nasrdistrict) (15% of the total number of farmers) it was 254 farmers. Questionnaire techniques and interviewswith the farmers were adopted to collect the data (March to May 2019). The study has revealed that the highestpercentage (62.6 %) belonged to the medium category in applying modern agricultural technology to improvewheat crop production. The application level of modern agricultural technology was significant and positiveat a 1% probability level under six variables. Multiple regression analyses have been studied with ten variables: social class, age, Education, Occupation, Farm power, Size of land holding, Family type, Family size,social participation, and source of information utilized. This research has contributed nine independent variables with significant levels of variation to the extent of the application level of modern agricultural technologyin improving wheat crop production (R2= 0.759). The importance of farmers using modern agricultural technology with the parts (Soil preparation, Planting and crop service, harvesting processes and marketing) washigh according to (72.12, 70.72, and 68.41) respectively. The data were used for analysis: Frequency, percentage, mean, Standard deviation, and multiple regression analysis. According to the result, farmers' applicationof modern technology in improving wheat crop production was good. Modern agricultural technology willreduce costs, increase productivity, and save soil quality. The importance of farmers with the parts (Soil preparation, Planting, crop service, harvesting processes, and marketing) was high according to (72.12, 70.72, and68.41) respectively. Because of this, it is necessary to improve the cultivation of wheat crops to achieve highproductivity and reduce the problems that happen during agricultural production.Keywords: Technology, Independent variables, Farmers, Harvesting, Size of land holding
本研究旨在确定济加尔省农民应用现代农业技术提高小麦作物产量的程度。本研究采用了多阶段样本概率大小比例(PPS)法。样本数为(75 名农民来自 Qalat Sukkar 区,105 名农民来自 AL-Rifai 区,45 名农民来自 AL-Shatrah 区,29 名农民来自 AL-Nasrd 区)(占农民总数的 15%),共 254 名农民。研究采用问卷调查和访谈的方式收集数据(2019 年 3 月至 5 月)。研究表明,在应用现代农业技术提高小麦作物产量方面,属于中等水平的比例最高(62.6%)。在六个变量中,现代农业技术的应用水平在 1%的概率水平上是显著和正向的。多元回归分析研究了 10 个变量:社会阶层、年龄、教育程度、职业、农场权力、土地保有量、家庭类型、家庭规模、社会参与和所利用的信息来源。研究发现,9 个自变量对现代农业技术在提高小麦作物产量方面的应用水平有显著影响(R2= 0.759)。农民使用现代农业技术的重要程度分别为(72.12、70.72 和 68.41)。数据用于分析:频率、百分比、平均值、标准差和多元回归分析。结果显示,农民应用现代技术提高小麦产量的情况良好。现代农业技术将降低成本、提高生产率并保护土壤质量。农民对各部分(土壤准备、种植、作物服务、收获过程和销售)的重视程度较高,分别为(72.12、70.72 和 68.41)。因此,有必要改进小麦作物的种植,以实现高生产率并减少农业生产过程中出现的问题:技术 自变量 农民 收获 土地保有量
{"title":"The Application of Wheat Farmers to Modern Agriculture Technology Related to Improve Crop Production in Thi-Qar","authors":"Hakeem, S. Abd. AL.Rekibe","doi":"10.21931/rb/2024.09.01.56","DOIUrl":"https://doi.org/10.21931/rb/2024.09.01.56","url":null,"abstract":"The research aim is to determine the level of application farmers of Modern Agricultural Technology have in\u0000improving wheat crop production in Thi-Qar Province. A multistage sample probability proportionates of size\u0000(PPS) was used to conduct this study. The sample number was (75 farmers from the Qalat Sukkar district, 105\u0000farmers from the AL-Rifai district, 45 farmers from the AL-Shatrah district, and 29 farmers from the AL-Nasr\u0000district) (15% of the total number of farmers) it was 254 farmers. Questionnaire techniques and interviews\u0000with the farmers were adopted to collect the data (March to May 2019). The study has revealed that the highest\u0000percentage (62.6 %) belonged to the medium category in applying modern agricultural technology to improve\u0000wheat crop production. The application level of modern agricultural technology was significant and positive\u0000at a 1% probability level under six variables. Multiple regression analyses have been studied with ten variables: social class, age, Education, Occupation, Farm power, Size of land holding, Family type, Family size,\u0000social participation, and source of information utilized. This research has contributed nine independent variables with significant levels of variation to the extent of the application level of modern agricultural technology\u0000in improving wheat crop production (R2= 0.759). The importance of farmers using modern agricultural technology with the parts (Soil preparation, Planting and crop service, harvesting processes and marketing) was\u0000high according to (72.12, 70.72, and 68.41) respectively. The data were used for analysis: Frequency, percentage, mean, Standard deviation, and multiple regression analysis. According to the result, farmers' application\u0000of modern technology in improving wheat crop production was good. Modern agricultural technology will\u0000reduce costs, increase productivity, and save soil quality. The importance of farmers with the parts (Soil preparation, Planting, crop service, harvesting processes, and marketing) was high according to (72.12, 70.72, and\u000068.41) respectively. Because of this, it is necessary to improve the cultivation of wheat crops to achieve high\u0000productivity and reduce the problems that happen during agricultural production.\u0000Keywords: Technology, Independent variables, Farmers, Harvesting, Size of land holding","PeriodicalId":505112,"journal":{"name":"Bionatura","volume":"120 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of energy poverty in Andean rural households and design of an efficient cooking solution using biomass 分析安第斯农村家庭的能源贫困状况,设计利用生物物质的高效烹饪解决方案
Pub Date : 2024-03-15 DOI: 10.21931/rb/2024.09.01.2
Wladimir A Silva-Castelo, Rafael Córdova-Uvidia, Ángel Ordoñez-Echeverria, Miguel Aquino-Arroba
This work explores energy poverty in the rural households surrounding the Chimborazo Faunal Production Reserve (RPFCH) and proposes an efficient cooking solution using firewood. Energy poverty was evaluated through the multidimensional poverty index (MEPI), including the 10% rule, hidden energy poverty, disproportionate expenses, and a subjective analysis of housing conditions. The research found ten households experiencing moderate energy poverty with a MEPI of 0,1562. An efficient cooking solution was proposed as an improved rocket stove design with an ignition system and forced air at the combustion chamber inlet. This stove utilizes a solar panel and batteries to power the fan. Its thermal efficiency is 13%, including Peltier cells to convert residual heat into DC electricity. The rocket stove's heating capacity is 1,6 kW, which is sufficient for heating a small room and cooking meals. After implementation, a follow-up energy poverty analysis using the same indicators is recommended to evaluate the effectiveness of the proposed solution and its impact on reducing energy poverty. Keywords: energy poverty; rocket stove; thermal efficiency; room heating; Peltier cell; photovoltaic energy.
这项研究探讨了钦博拉索动物生产保护区(RPFCH)周边农村家庭的能源贫困问题,并提出了一种利用木柴高效烹饪的解决方案。能源贫困通过多维贫困指数(MEPI)进行评估,包括 10% 规则、隐性能源贫困、不成比例的支出以及对住房条件的主观分析。研究发现,有 10 户家庭属于中度能源贫困,多维贫困指数为 0.1562。研究提出了一种高效的烹饪解决方案,即改进的火箭炉灶设计,带有点火系统,并在燃烧室入口处强制通风。这种炉灶利用太阳能电池板和电池为风扇供电。其热效率为 13%,包括将余热转化为直流电的珀尔帖电池。火箭炉的供暖能力为 1.6 千瓦,足以为一个小房间供暖和做饭。建议在实施后,使用相同的指标进行后续能源贫困分析,以评估所提出的解决方案的有效性及其对减少能源贫困的影响。关键词:能源贫困;火箭炉;热效率;室内取暖;珀尔帖电池;光伏能源。
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引用次数: 0
Niveles de Vitamina D en pacientes con y sin Enfermedad Renal Crónica, perfil clínico y epidemiológico: un análisis preeliminiar en un hospital de segundo nivel en quito, Ecuador. 慢性肾病患者和非慢性肾病患者的维生素 D 水平、临床和流行病学概况:厄瓜多尔基多一家二级医院的初步分析。
Pub Date : 2024-03-15 DOI: 10.21931/rb/2024.09.01.43
André Benítez-Baldassari, Estefanía León-Hernández, Andrea Banegas-Sarmiento, Santiago Aguayo-Moscoso, J. Vélez-Páez
Vitamin D has been associated with different effects unrelated to bone-mineral metabolism, such as its association with arterial hypertension. This study determines the prevalence profile of vitamin D deficiency andinsufficiency in Ecuadorian patients, its epidemiological profile, and its relationship with other diseases suchas arterial hypertension, diabetes mellitus, and chronic kidney disease. This is a pioneering study in Ecuadorof a retrospective type, carried out at the Pablo Arturo Suarez Hospital over 6 months, in which it was foundthat the prevalence of vitamin D insufficiency was 28.5% (levels between 21 to 30 ng/ml) and deficiency was57% (levels less than 20 ng/ml); Likewise, we ratify the inverse relationship between vitamin D levels andage, as well as finding a certain association between vitamin D levels and the presence of arterial hypertension;while no significant differences were found in its relationship with diabetes mellitus, chronic kidney diseasewithout the use of renal replacement therapy and the general population.Keywords: vitamin D, chronic kidney disease, metabolism.
维生素 D 具有与骨矿物质代谢无关的各种作用,例如与动脉高血压有关。本研究确定了厄瓜多尔患者维生素 D 缺乏和不足的患病情况、流行病学特征及其与其他疾病(如动脉高血压、糖尿病和慢性肾病)的关系。这是厄瓜多尔的一项开创性回顾性研究,该研究在巴勃罗-阿图罗-苏亚雷斯医院进行,历时 6 个月。同样,我们还证实了维生素D水平与年龄之间的反比关系,并发现维生素D水平与动脉高血压之间存在一定的联系;而维生素D水平与糖尿病、未使用肾脏替代疗法的慢性肾脏病以及普通人群之间的关系则没有发现显著差异。
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引用次数: 0
Anthropometric indicators and their relationship with body fat in obese women. 肥胖女性的人体测量指标及其与体脂的关系。
Pub Date : 2024-03-15 DOI: 10.21931/rb/2024.09.01.3
Yury Rosales-Ricardo, Vinicio Caiza-Ruiz, Sonia Álvarez-Carrión
To determine the anthropometric indicator of best correlation with body fat in women with obesity aged 20 to 59 years. A correlational cross-sectional study was conducted. The percentage of body fat was determined (% GC) and lipid profile (LDL, TG, CT), Body Mass Index (BMI), Hip Waist Index (ICC), Waist Height Index (ICE), Conicity Index (CI), Body Adiposity Index (BSI), Hip Height Index (HSI) and Body Weight by Height Index (BWI). Seven hundred and eighty obese women were selected by random cluster sampling. The correlation of the mean % GC with anthropometric indicators was: BMI:0.697, ICC: 0.661, ECI: 0.910, CI: 0.587, ICadE: 0.323, CAI: 0.578, EICP: 0.549. The lipid profile correlation with anthropometric variables and indices was: LDL (BMI: 0.615, ICC: 0.765, ECI: 0.881, CSI: 0.535, ICadE: 0.588, ECDI: 0.492), TG (BMI: 0.690, ICC: 0.776, ICE: 0.855, CI:0.625, CI: 0.572, CIadE: 0.632, EICP: 0.631) Y TC (BMI: 0.699, ICC: 0.715, ECI: 0.829, CI: 0.601, ACI: 0.609, CIadE: 0.709, EICP: 0.500) High correlation between % GC and Waist Circumference. Waist Height Index had a better correlation with Body Fat.Keywords: obesity; health; women; nutritional status
确定与 20 至 59 岁肥胖女性体脂相关性最佳的人体测量指标。我们进行了一项相关横断面研究。研究测定了体脂百分比(GC%)、血脂谱(LDL、TG、CT)、体重指数(BMI)、臀腰指数(ICC)、腰高指数(ICE)、脐带指数(CI)、体脂指数(BSI)、臀高指数(HSI)和身高体重指数(BWI)。随机分组抽取了 78 名肥胖妇女。平均 GC%与人体测量指标的相关性为BMI:0.697,ICC:0.661,ECI:0.910,CI:0.587,ICadE:0.323,CAI:0.578,EICP:0.549。血脂概况与人体测量变量和指数的相关性为低密度脂蛋白(BMI:0.615,ICC:0.765,ECI:0.881,CSI:0.535,ICadE:0.588,ECDI:0.492),总胆固醇(BMI:0.690,ICC:0.776,ICE:0.855,CI:0.625,CI:0.572,CIadE:0.632,EICP:0.631)Y TC(BMI:0.699,ICC:0.715,ECI:0.829,CI:0.601,ACI:0.609,CIadE:0.709,EICP:0.500) GC%与腰围之间存在高度相关性。关键词:肥胖;健康;妇女;营养状况
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引用次数: 0
Histopathological effects of Cryptococcus neoformans on liver and kidney in mice 新生隐球菌对小鼠肝脏和肾脏的组织病理学影响
Pub Date : 2024-03-15 DOI: 10.21931/rb/2024.09.01.49
Sara Saad Hussamaldeen Al-Bakir, Dalia Abdalkareem Abdalshaheed
This study provides a brief review of approaches for the detection of histopathological effects of Cryptococcusneoformans on the liver and kidney in mice that were injected I/P with 105 yeast cells of C. neoformans suspended in 1 ml phosphate-buffered saline at a single dose. After 14 days, the mice were sacrificed, and histopathological sections from the liver and kidney were prepared and stained with Haematoxylin and Eosin bythe P.A.S. method. The results show that the liver was infiltrated with inflammatory cells, primarily mononuclear cells, in the portal. In addition to the activation of Kupffer cells and vacillation of hepatocytes, mostblood vessels were congested. The section of the kidney shows sluffing of epithelia lining tubules and destruction of glomeruli, in addition to infiltration of mononuclear cells. These results suggested that the fungusinvasiveness of mice has substantial effects on vital organs and may lead to death.Keywords: Cryptococcus neoformans, Hepatic cryptococcal infection, Cryptococcus
本研究简要回顾了检测隐球菌对小鼠肝脏和肾脏组织病理学影响的方法,小鼠经静脉/静脉注射单剂量悬浮于 1 毫升磷酸盐缓冲盐水中的 105 个新形隐球菌酵母细胞。14 天后,小鼠被处死,制备肝脏和肾脏的组织病理学切片,并用 P.A.S. 法进行血色素和伊红染色。结果显示,肝门部有炎症细胞浸润,主要是单核细胞。除了 Kupffer 细胞活化和肝细胞空泡化外,大部分血管充血。肾脏切片显示,除单核细胞浸润外,肾小管上皮脱落,肾小球被破坏。这些结果表明,小鼠的真菌侵袭会对重要器官产生实质性影响,并可能导致死亡:新型隐球菌 肝隐球菌感染 隐球菌
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引用次数: 0
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