Pub Date : 2024-03-15DOI: 10.21931/rb/2024.09.01.62
Ghada A. Mohammad, Huda Waleed Hadi
The attempts are continuing in the various fields of life sciences to resolve a big problem, which is the ability of bacteria to cause pathogenicity for humans, animals, and plants, whether by chemical or biological methods and in ways that are hoped to be safe. Among these attempts, the control of the Quorum Sensing (QS) mechanism that occurs naturally in bacteria under certain conditions helps to increase the virulence of bacteria, starting from its ability to adhere and form a biofilm. Then, the tissues are invaded with various enzymes according to the tissue type, increasing antibiotic resistance. Therefore, the idea came to solve these problems through a mechanism opposite to the Quorum Quenching (QQ), which lies in the investigation of substances that can disrupt the QS pathway, whether at the molecular level or the physiological level, as well as benefiting from different organisms (Prokaryotes or Eukaryotes) that live in the same environment and produce substances that inhibit bacterial signaling molecules. Lastly, the discovery of varying novel QQ agents from extreme environmental bacteria will be most interesting in the future. Keywords: Quorum sensing, quorum quenching, acyl homoserine lactones, medical application
{"title":"The Role of Quorum Quenching in Medical Application","authors":"Ghada A. Mohammad, Huda Waleed Hadi","doi":"10.21931/rb/2024.09.01.62","DOIUrl":"https://doi.org/10.21931/rb/2024.09.01.62","url":null,"abstract":"The attempts are continuing in the various fields of life sciences to resolve a big problem, which is the ability\u0000of bacteria to cause pathogenicity for humans, animals, and plants, whether by chemical or biological methods\u0000and in ways that are hoped to be safe. Among these attempts, the control of the Quorum Sensing (QS) mechanism that occurs naturally in bacteria under certain conditions helps to increase the virulence of bacteria,\u0000starting from its ability to adhere and form a biofilm. Then, the tissues are invaded with various enzymes\u0000according to the tissue type, increasing antibiotic resistance. Therefore, the idea came to solve these problems\u0000through a mechanism opposite to the Quorum Quenching (QQ), which lies in the investigation of substances\u0000that can disrupt the QS pathway, whether at the molecular level or the physiological level, as well as benefiting\u0000from different organisms (Prokaryotes or Eukaryotes) that live in the same environment and produce substances that inhibit bacterial signaling molecules. Lastly, the discovery of varying novel QQ agents from extreme environmental bacteria will be most interesting in the future.\u0000Keywords: Quorum sensing, quorum quenching, acyl homoserine lactones, medical application","PeriodicalId":505112,"journal":{"name":"Bionatura","volume":"16 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.21931/rb/2024.09.01.60
T. Hayder Hasan, Ameer Sadeq Yasir AL-Ethari, S. Ghani Al-Muhanna, Israa Abdul Ameer Al-Kraety
Acinetobacter baumannii is a Gram-negative bacterium characterized by its short, round, rod-shaped morphology. It is an opportunistic pathogen that poses a significant threat, particularly to immunocompromised patients, often those with hospital stays lasting less than 90 days. Between June 2022 and July 2023, 214 urine samples were collected from individuals suspected of having urinary tract infections (UTIs). These samples were subjected to antibiotic resistance testing, focusing on detecting specific genes related to carbapenem resistance, namely blaNDM, blaKPC, and blaVIM.The study's results revealed a notable trend in antibiotic resistance among the bacterial isolates. Ceftazidime, cefotaxime, and ceftriaxone, commonly used antibiotics for UTIs, showed a high resistance rate among the tested isolates. This resistance highlights the challenges healthcare professionals face when treating UTIs caused by Acinetobacter baumannii. On the other hand, the isolates displayed a comparatively lower resistance rate to imipenem and meropenem, two necessary carbapenem antibiotics. This lower resistance to carbapenems is encouraging as these drugs are often considered the last line of defense against multidrug-resistant bacterial infections. The presence of carbapenem resistance genes, such as blaNDM, blaKPC, and blaVIM, in the Acinetobacter baumannii isolates is of particular concern. These genes confer resistance to carbapenem antibiotics, crucial for treating severe infections caused by multidrug-resistant bacteria. In conclusion, the study aims to study the growth of antibiotic resistance in Acinetobacter baumannii, especially in urinary tract infections in immunocompromised patients with more extended hospital stays. It also highlights the need for Surveys and periodic examinations to detect the spread of bacteria and their resistance. Keywords: Carbapenems, UTI, genes, blaNDM, blaKPC, and blaVIM.
{"title":"Genotypic Detection of Carbapenems Resistance Genes in Acinetobacter baumannii Isolated from\u0000Urinary Tract Infection Patients","authors":"T. Hayder Hasan, Ameer Sadeq Yasir AL-Ethari, S. Ghani Al-Muhanna, Israa Abdul Ameer Al-Kraety","doi":"10.21931/rb/2024.09.01.60","DOIUrl":"https://doi.org/10.21931/rb/2024.09.01.60","url":null,"abstract":"Acinetobacter baumannii is a Gram-negative bacterium characterized by its short, round, rod-shaped morphology. It is an opportunistic pathogen that poses a significant threat, particularly to immunocompromised\u0000patients, often those with hospital stays lasting less than 90 days. Between June 2022 and July 2023, 214 urine\u0000samples were collected from individuals suspected of having urinary tract infections (UTIs). These samples\u0000were subjected to antibiotic resistance testing, focusing on detecting specific genes related to carbapenem\u0000resistance, namely blaNDM, blaKPC, and blaVIM.The study's results revealed a notable trend in antibiotic\u0000resistance among the bacterial isolates. Ceftazidime, cefotaxime, and ceftriaxone, commonly used antibiotics\u0000for UTIs, showed a high resistance rate among the tested isolates. This resistance highlights the challenges\u0000healthcare professionals face when treating UTIs caused by Acinetobacter baumannii. On the other hand, the\u0000isolates displayed a comparatively lower resistance rate to imipenem and meropenem, two necessary carbapenem antibiotics. This lower resistance to carbapenems is encouraging as these drugs are often considered\u0000the last line of defense against multidrug-resistant bacterial infections. The presence of carbapenem resistance\u0000genes, such as blaNDM, blaKPC, and blaVIM, in the Acinetobacter baumannii isolates is of particular concern. These genes confer resistance to carbapenem antibiotics, crucial for treating severe infections caused by\u0000multidrug-resistant bacteria. In conclusion, the study aims to study the growth of antibiotic resistance in Acinetobacter baumannii, especially in urinary tract infections in immunocompromised patients with more extended hospital stays. It also highlights the need for Surveys and periodic examinations to detect the spread of\u0000bacteria and their resistance.\u0000Keywords: Carbapenems, UTI, genes, blaNDM, blaKPC, and blaVIM.","PeriodicalId":505112,"journal":{"name":"Bionatura","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}