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The recent advances and implications in cancer therapy for the hippo pathway
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-04 DOI: 10.1016/j.ceb.2025.102476
Siew Wee Chan, Camellia Ong, Wanjin Hong
The Hippo pathway is a highly conserved signaling network integrating diverse intracellular, intercellular and extracellular biological cues to regulate complex physiological processes such as organ size, tissue development, homeostasis and regeneration. These cues include cytoskeletal organization, mechanical force, cell–cell interaction, cell polarity, cell-extracellular matrix interaction to govern cell proliferation, differentiation, apoptosis, stem cell property and tissue microenvironment. In this review, we discuss how the emerging role of biomolecular condensates regulates the activity of the pathway components, and how dysregulation of the pathway leads to cancer. Lastly, we highlight the therapeutic modalities which target YAP/TAZ-TEAD interaction for cancer therapy.
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引用次数: 0
Shining a light on cell biology of the nucleus with single-cell sequencing
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-03 DOI: 10.1016/j.ceb.2025.102468
Jeroen van den Berg , Peter Zeller
From the preservation of genomic integrity to the regulation of RNA translation, nearly all cellular processes are regulated in a cell context-dependent manner. To fully understand the context-specific function of involved nuclear processes, a vast number of single-cell sequencing technologies were developed over the last decade. This instrumental work demonstrated the heterogeneity between cell types and individual cells, bringing about new understanding of nuclear mechanisms and their crosstalk to cell states. In this review, we will cover new technological advances and their exciting applications as well as future opportunities to discover new nuclear processes and the crosstalk between them.
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引用次数: 0
Unconventional protein secretion: Exploring membrane proteins and beyond
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-03 DOI: 10.1016/j.ceb.2025.102469
Long Lin
Protein secretion is essential for cellular communication and function, enabling the delivery of both soluble and integral membrane proteins to the extracellular space and the cell surface. While the classical endoplasmic reticulum (ER)–Golgi pathway has been extensively studied, emerging evidence highlights the existence of unconventional protein secretion (UcPS) pathways. Among these, the mechanisms that enable membrane proteins to bypass the Golgi apparatus remain poorly understood. In this review, I discuss recent advances that shed light on the processes governing Golgi-bypassing membrane secretion. These findings reveal that UcPS of membrane proteins is evolutionarily conserved, operates under both physiological and stress conditions, and involves diverse intermediate carriers and molecular players. Looking ahead, advances in technology and the development of more sophisticated functional assays, along with in vivo models, are expected to further unravel the molecular mechanisms and biological roles of these unconventional pathways.
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引用次数: 0
Beyond static snapshots: Mitochondria in action 超越静态快照：行动中的线粒体
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-01 DOI: 10.1016/j.ceb.2024.102460
Julien Cicero, Uri Manor
Mitochondria are dynamic organelles essential for cellular homeostasis, undergoing continuous fission and fusion processes that regulate their morphology, distribution, and function. Disruptions in these dynamics are linked to numerous diseases, including neurodegenerative disorders and cancer. Understanding these processes is vital for developing therapeutic strategies aimed at mitigating mitochondrial dysfunction. This review provides an overview of recent perspectives on mitochondrial dynamics, focusing on the need for live video microscopy imaging in order to fully understand mitochondrial phenotypes and pathology. Advanced imaging tools, such as machine learning-based segmentation and label-free microscopy approaches, have the potential to transform our ability to study mitochondrial dynamics in live cells.
线粒体是对细胞平衡至关重要的动态细胞器，它经历着连续的裂变和融合过程，这些过程调节着线粒体的形态、分布和功能。这些动态过程的破坏与多种疾病有关，包括神经退行性疾病和癌症。了解这些过程对于制定旨在缓解线粒体功能障碍的治疗策略至关重要。本综述概述了有关线粒体动力学的最新观点，重点关注为全面了解线粒体表型和病理而进行实时视频显微成像的必要性。先进的成像工具，如基于机器学习的分割和无标记显微镜方法，有可能改变我们研究活细胞线粒体动力学的能力。
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引用次数: 0
Outside Back Cover
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-01 DOI: 10.1016/S0955-0674(25)00013-4
{"title":"Outside Back Cover","authors":"","doi":"10.1016/S0955-0674(25)00013-4","DOIUrl":"10.1016/S0955-0674(25)00013-4","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"92 ","pages":"Article 102475"},"PeriodicalIF":6.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opening the gate: Complexity and modularity of the nuclear pore scaffold and basket 打开大门：核孔支架和筐的复杂性和模块化。
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-01 DOI: 10.1016/j.ceb.2024.102461
Elisa Dultz , Valérie Doye
Nuclear pore complexes (NPCs) are giant molecular assemblies that form the gateway between the nucleus and the cytoplasm and accommodate the bidirectional transport of a large variety of cargoes. Recent years have seen tremendous advances in our understanding of their building principles and have in particular called attention to the flexibility and variability of NPC composition and structure. Here, we review these recent advances and discuss how the newest technologies push the boundaries of nuclear pore research forward, with a specific highlight on the NPC scaffold and a prominent pore appendage, the nuclear basket, whose architecture has long been elusive.
核孔复合物（NPCs）是一种巨大的分子组合物，形成细胞核和细胞质之间的通道，并容纳各种货物的双向运输。近年来，我们对NPC建筑原则的理解取得了巨大进步，并特别关注NPC组成和结构的灵活性和可变性。在这里，我们回顾了这些最新的进展，并讨论了最新的技术如何推动核孔研究的边界向前发展，特别强调了NPC支架和一个突出的孔附件，核篮，其结构长期以来一直难以捉摸。
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引用次数: 0
Organization of the chromosomal passenger complex clusters at inner centromeres in mitosis 有丝分裂中染色体内着丝粒的载客复合体簇的组织。
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-01 DOI: 10.1016/j.ceb.2024.102462
Saho Matsui , Ryu-Suke Nozawa , Toru Hirota
Stable transmission of the genome during cell division is crucial for all life forms and is universally achieved by Aurora B-mediated error correction of the kinetochore-microtubule attachments. Aurora B is the enzymatic subunit of the tetrameric protein complex called the chromosomal passenger complex (CPC), and its centromeric enrichment is required for Aurora B to ensure accurate chromosome segregation. How cells enrich the CPC at centromeres is therefore an outstanding question to be elucidated. We review our recent understanding of how CPCs are assembled at inner centromeres in mitosis, the mechanism depending on mitotic histone phosphorylations and beyond.
在细胞分裂过程中，基因组的稳定传递对所有生命形式都是至关重要的，并且普遍通过极光b介导的着丝点-微管附着物的错误纠正来实现。Aurora B是四聚体蛋白复合物（称为染色体乘客复合物（CPC））的酶亚基，为了确保准确的染色体分离，Aurora B需要对其进行着丝粒富集。因此，细胞如何在着丝粒富集CPC是一个有待阐明的突出问题。我们回顾了我们最近对有丝分裂中CPCs如何在内部着丝粒组装的理解，其机制取决于有丝分裂组蛋白磷酸化等。
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引用次数: 0
Regulation of actin dynamics by Twinfilin
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-01 DOI: 10.1016/j.ceb.2024.102459
Heidi Ulrichs, Shashank Shekhar
Twinfilin is an evolutionarily conserved actin-binding protein initially mischaracterized as a tyrosine kinase but later recognized as a key regulator of cellular actin dynamics. As a member of the ADF-H family, twinfilin binds both actin monomers and filaments. Its role in sequestering G-actin is well-established, but its effects on actin filaments have been debated. While early studies suggested twinfilin caps filament barbed ends, later research demonstrated its role in nucleotide-specific barbed-end depolymerization. Further, it was initially thought to be a processive depolymerase. Recent structural and single-molecule studies have however challenged this view, indicating that twinfilin binding events result in the removal of only one or two actin subunits from the barbed end. Additionally, twinfilin directly binds capping protein (CP) and facilitates uncapping of CP-bound barbed ends. Here, we summarize twinfilin's cellular and tissue-specific localization, and examine its evolving role in regulating cellular actin dynamics in light of its known biochemical functions.
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引用次数: 0
Prolonged mitosis: A key indicator for detecting stressed and damaged cells 延长有丝分裂：检测受压和受损细胞的关键指标。
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-01 DOI: 10.1016/j.ceb.2024.102449
Carmen Sparr, Franz Meitinger
During mitosis, chromosomes condense, align to form a metaphase plate and segregate to the two daughter cells. Mitosis is one of the most complex recurring transformations in the life of a cell and requires a high degree of reliability to ensure the error-free transmission of genetic information to the next cell generation. An abnormally prolonged mitosis indicates potential defects that compromise genomic integrity. The mitotic stopwatch pathway detects even moderately prolonged mitoses by integrating memories of mitotic durations, ultimately leading to p53-mediated cell cycle arrest or death. This mechanism competes with mitogen signaling to stop the proliferation of damaged and potentially dangerous cells at a pre-oncogenic stage. Mitosis is a highly vulnerable phase, which is affected by multiple types of cellular damages and diverse stresses. We discuss the hypothesis that the duration of mitosis serves as an indicator of cell health.
在有丝分裂期间，染色体凝聚，排列形成中期板，并分离成两个子细胞。有丝分裂是细胞生命中最复杂的循环转化之一，需要高度的可靠性来确保遗传信息无错误地传递给下一代细胞。异常延长的有丝分裂表明潜在的缺陷损害了基因组的完整性。有丝分裂秒表通路通过整合有丝分裂持续时间的记忆来检测中度延长的有丝分裂，最终导致p53介导的细胞周期阻滞或死亡。这一机制与丝裂原信号竞争，在癌前阶段阻止受损和潜在危险细胞的增殖。有丝分裂是一个非常脆弱的阶段，它受到多种类型的细胞损伤和多种胁迫的影响。我们讨论了有丝分裂持续时间作为细胞健康指标的假设。
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引用次数: 0
Moving the fat: Emerging roles of rab GTPases in the regulation of lipid droplet contact sites
IF 6 2区 生物学 Q1 CELL BIOLOGY
Current Opinion in Cell Biology
Pub Date : 2025-02-01 DOI: 10.1016/j.ceb.2025.102466
Mariano Alonso-Bivou , Albert Pol , Harriet P. Lo
Lipid droplets (LDs) play crucial roles in lipid metabolism, energy homeostasis, and cellular stress. Throughout their lifecycle, LDs establish membrane contact sites (MCSs) with the endoplasmic reticulum, mitochondria, peroxisomes, endosomes, lysosomes, and phagosomes. LD MCSs are dynamically generated in response to metabolic or immune cues to ensure that LD lipids (and proteins) are timely delivered to optimize valuable substrates and avoid lipotoxicity. It is increasingly evident that many Rab GTPases are involved in LD dynamics. Here, we summarize our current understanding of how and when Rab proteins dynamically drive the generation of LD MCSs and regulate a variety of LD functions.
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引用次数: 0
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Current Opinion in Cell Biology
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