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Layer-by-Layer Biomaterials for Drug Delivery. 用于给药的逐层生物材料。
IF 9.7 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 Epub Date: 2020-02-21 DOI: 10.1146/annurev-bioeng-060418-052350
Dahlia Alkekhia, Paula T Hammond, Anita Shukla

Controlled drug delivery formulations have revolutionized treatments for a range of health conditions. Over decades of innovation, layer-by-layer (LbL) self-assembly has emerged as one of the most versatile fabrication methods used to develop multifunctional controlled drug release coatings. The numerous advantages of LbL include its ability to incorporate and preserve biological activity of therapeutic agents; coat multiple substrates of all scales (e.g., nanoparticles to implants); and exhibit tuned, targeted, and/or responsive drug release behavior. The functional behavior of LbL films can be related to their physicochemical properties. In this review, we highlight recent advances in the development of LbL-engineered biomaterials for drug delivery, demonstrating their potential in the fields of cancer therapy, microbial infection prevention and treatment, and directing cellular responses. We discuss the various advantages of LbL biomaterial design for a given application as demonstrated through in vitro and in vivo studies.

控制药物输送配方已经彻底改变了一系列健康状况的治疗方法。经过几十年的创新,层层自组装(LbL)已经成为开发多功能药物释放涂层的最通用的制造方法之一。LbL的众多优点包括其结合和保持治疗剂生物活性的能力;覆盖各种尺度的多种基底(例如,将纳米颗粒涂覆到植入物上);并表现出调整,靶向和/或反应性药物释放行为。LbL薄膜的功能行为与其物理化学性质有关。在这篇综述中,我们重点介绍了用于药物递送的lbl工程生物材料的最新进展,展示了它们在癌症治疗、微生物感染预防和治疗以及指导细胞反应等领域的潜力。我们讨论了通过体外和体内研究证明的LbL生物材料设计在特定应用中的各种优势。
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引用次数: 102
4D Flow with MRI. 4D Flow with MRI。
IF 9.7 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 Epub Date: 2020-03-10 DOI: 10.1146/annurev-bioeng-100219-110055
Gilles Soulat, Patrick McCarthy, Michael Markl

Magnetic resonance imaging (MRI) has become an important tool for the clinical evaluation of patients with cardiac and vascular diseases. Since its introduction in the late 1980s, quantitative flow imaging with MRI has become a routine part of standard-of-care cardiothoracic and vascular MRI for the assessment of pathological changes in blood flow in patients with cardiovascular disease. More recently, time-resolved flow imaging with velocity encoding along all three flow directions and three-dimensional (3D) anatomic coverage (4D flow MRI) has been developed and applied to enable comprehensive 3D visualization and quantification of hemodynamics throughout the human circulatory system. This article provides an overview of the use of 4D flow applications in different cardiac and vascular regions in the human circulatory system, with a focus on using 4D flow MRI in cardiothoracic and cerebrovascular diseases.

磁共振成像(MRI)已成为临床评价心血管疾病患者的重要工具。自20世纪80年代末引入以来,MRI定量血流成像已成为标准护理心胸和血管MRI的常规部分,用于评估心血管疾病患者血流的病理变化。最近,时间分辨率的血流成像,沿着所有三个流动方向的速度编码和三维(3D)解剖覆盖(4D血流MRI)已经开发并应用于实现整个人体循环系统的血流动力学的全面3D可视化和量化。本文综述了4D血流在人体循环系统中不同心脏和血管区域的应用,重点介绍了4D血流MRI在心胸脑血管疾病中的应用。
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引用次数: 48
Transgenic and Diet-Enhanced Silk Production for Reinforced Biomaterials: A Metamaterial Perspective. 转基因和膳食增强丝生产增强生物材料:一个超材料的观点。
IF 9.7 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 Epub Date: 2020-03-11 DOI: 10.1146/annurev-bioeng-082719-032747
Jung Woo Leem, Malcolm J Fraser, Young L Kim

Silk fibers, which are protein-based biopolymers produced by spiders and silkworms, are fascinating biomaterials that have been extensively studied for numerous biomedical applications. Silk fibers often have remarkable physical and biological properties that typical synthetic materials do not exhibit. These attributes have prompted a wide variety of silk research, including genetic engineering, biotechnological synthesis, and bioinspired fiber spinning, to produce silk proteins on a large scale and to further enhance their properties. In this review, we describe the basic properties of spider silk and silkworm silk and the important production methods for silk proteins. We discuss recent advances in reinforced silk using silkworm transgenesis and functional additive diets with a focus on biomedical applications. We also explain that reinforced silk has an analogy with metamaterials such that user-designed atypical responses can be engineered beyond what naturally occurring materials offer. These insights into reinforced silk can guide better engineering of superior synthetic biomaterials and lead to discoveries of unexplored biological and medical applications of silk.

丝纤维是由蜘蛛和蚕产生的蛋白质基生物聚合物,是一种令人着迷的生物材料,已被广泛研究用于许多生物医学应用。丝绸纤维通常具有典型合成材料所不具备的非凡的物理和生物特性。这些特性促使了各种各样的蚕丝研究,包括基因工程、生物技术合成和生物纤维纺丝,以大规模生产蚕丝蛋白并进一步提高其性能。本文综述了蜘蛛丝和蚕丝的基本特性以及蚕丝蛋白的重要生产方法。我们讨论了利用蚕转基因和功能性添加剂饲料增强蚕丝的最新进展,重点是生物医学应用。我们还解释说,增强丝与超材料有相似之处,因此用户设计的非典型反应可以被设计成超越天然材料所提供的。这些对增强丝的见解可以指导更好的工程合成高级生物材料,并导致发现未开发的丝的生物和医学应用。
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引用次数: 14
Elastin-Like Polypeptides for Biomedical Applications. 生物医学应用的类弹性蛋白多肽。
IF 9.7 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 Epub Date: 2020-04-28 DOI: 10.1146/annurev-bioeng-092419-061127
Anastasia K Varanko, Jonathan C Su, Ashutosh Chilkoti
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties-including lower critical solution temperature phase behavior and minimal immunogenicity-make them attractive materials for a variety of biomedical applications. ELPs also benefit from recombinant synthesis and genetically encoded design; these enable control over the molecular weight and precise incorporation of peptides and pharmacological agents into the sequence. Because their size and sequence are defined, ELPs benefit from exquisite control over their structure and function, qualities that cannot be matched by synthetic polymers. As such, ELPs have been engineered to assemble into unique architectures and display bioactive agents for a variety of applications. This review discusses the design and representative biomedical applications of ELPs, focusing primarily on their use in tissue engineering and drug delivery. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 22 is June 4, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
弹性蛋白样多肽(ELPs)是来源于人体弹性蛋白的刺激反应性生物聚合物。它们独特的性质——包括较低的临界溶液温度相行为和最小的免疫原性——使它们成为各种生物医学应用的有吸引力的材料。elp还受益于重组合成和基因编码设计;这使得控制分子量和精确结合肽和药理学制剂进入序列。由于它们的大小和序列是确定的,因此elp受益于对其结构和功能的精细控制,而这些特性是合成聚合物无法比拟的。因此,elp已被设计成独特的结构,并显示各种应用的生物活性剂。本文综述了elp的设计和具有代表性的生物医学应用,主要侧重于其在组织工程和药物传递中的应用。
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引用次数: 98
Integrated Biophysical Modeling and Image Analysis: Application to Neuro-Oncology. 综合生物物理建模和图像分析:在神经肿瘤学中的应用。
IF 12.8 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 DOI: 10.1146/annurev-bioeng-062117-121105
Andreas Mang, Spyridon Bakas, Shashank Subramanian, Christos Davatzikos, George Biros

Central nervous system (CNS) tumors come with vastly heterogeneous histologic, molecular, and radiographic landscapes, rendering their precise characterization challenging. The rapidly growing fields of biophysical modeling and radiomics have shown promise in better characterizing the molecular, spatial, and temporal heterogeneity of tumors. Integrative analysis of CNS tumors, including clinically acquired multi-parametric magnetic resonance imaging (mpMRI) and the inverse problem of calibrating biophysical models to mpMRI data, assists in identifying macroscopic quantifiable tumor patterns of invasion and proliferation, potentially leading to improved (a) detection/segmentation of tumor subregions and (b) computer-aided diagnostic/prognostic/predictive modeling. This article presents a summary of (a) biophysical growth modeling and simulation,(b) inverse problems for model calibration, (c) these models' integration with imaging workflows, and (d) their application to clinically relevant studies. We anticipate that such quantitative integrative analysis may even be beneficial in a future revision of the World Health Organization (WHO) classification for CNS tumors, ultimately improving patient survival prospects.

中枢神经系统(CNS)肿瘤具有极其异质的组织学、分子和放射学景观,使其精确表征具有挑战性。快速发展的生物物理建模和放射组学领域在更好地表征肿瘤的分子、空间和时间异质性方面显示出了前景。中枢神经系统肿瘤的综合分析,包括临床获得的多参数磁共振成像(mpMRI)和将生物物理模型校准为mpMRI数据的逆问题,有助于识别侵袭和增殖的宏观可量化肿瘤模式,可能导致改进(a)肿瘤亚区的检测/分割和(b)计算机辅助诊断/预后/预测建模。本文概述了(a)生物物理生长建模和模拟,(b)模型校准的逆问题,(c)这些模型与成像工作流程的集成,以及(d)它们在临床相关研究中的应用。我们预计,这种定量综合分析甚至可能有利于世界卫生组织(世界卫生组织)中枢神经系统肿瘤分类的未来修订,最终改善患者的生存前景。
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引用次数: 0
Engineering Approaches for Addressing Opioid Use Disorder in the Community. 解决社区阿片类药物使用障碍的工程方法。
IF 9.7 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 Epub Date: 2020-04-07 DOI: 10.1146/annurev-bioeng-082719-040832
Paul M Griffin

Many communities in the United States are struggling to deal with the negative consequences of illicit opioid use. Effectively addressing this epidemic requires the coordination and support of community stakeholders in a change process with common goals and objectives, continuous engagement with individuals with opioid use disorder (OUD) through their treatment and recovery journeys, application of systems engineering principles to drive process change and sustain it, and use of a formal evaluation process to support a learning community that continuously adapts. This review presents strategies to improve OUD treatment and recovery with a focus on engineering approaches grounded in systems thinking.

美国的许多社区都在努力应对非法使用阿片类药物的负面后果。有效应对这一流行病需要社区利益攸关方在具有共同目标的变革过程中进行协调和支持,在治疗和康复过程中与阿片类药物使用障碍(OUD)患者持续接触,应用系统工程原则推动流程变革并维持流程变革,并使用正式评估过程来支持不断适应的学习型社区。这篇综述介绍了改善OUD治疗和恢复的策略,重点是基于系统思维的工程方法。
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引用次数: 7
Point-of-Care Devices to Detect Zika and Other Emerging Viruses. 检测寨卡和其他新出现病毒的即时医疗设备。
IF 9.7 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 DOI: 10.1146/annurev-bioeng-060418-052240
Helena de Puig, Irene Bosch, James J Collins, Lee Gehrke

Rapid diagnostic tests (point-of-care devices) are critical components of informed patient care and public health monitoring (surveillance applications). We propose that among the many rapid diagnostics platforms that have been tested or are in development, lateral flow immunoassays and synthetic biology-based diagnostics (including CRISPR-based diagnostics) represent the best overall options given their ease of use, scalability for manufacturing, sensitivity, and specificity. This review describes the identification of lateral flow immunoassay monoclonal antibody pairs that detect and distinguish between closely related pathogens and that are used in combination with functionalized multicolored nanoparticles and computational methods to deconvolute data. We also highlight the promise of synthetic biology-based diagnostic tests, which use synthetic genetic circuits that activate upon recognition of a pathogen-associated nucleic acid sequence, and discuss how the combined or parallel use of lateral flow immunoassays and synthetic biology tools may represent the future of scalable rapid diagnostics.

快速诊断测试(护理点设备)是知情患者护理和公共卫生监测(监测应用)的关键组成部分。我们建议,在许多已经测试或正在开发的快速诊断平台中,横向流动免疫测定和基于合成生物学的诊断(包括基于crispr的诊断)代表了最佳的整体选择,因为它们易于使用,易于制造,灵敏度和特异性。这篇综述描述了侧流免疫测定单克隆抗体对的鉴定,这种抗体对可以检测和区分密切相关的病原体,并与功能化的彩色纳米颗粒和计算方法结合使用来解卷积数据。我们还强调了基于合成生物学的诊断测试的前景,它使用在识别病原体相关核酸序列时激活的合成遗传电路,并讨论了横向流动免疫测定和合成生物学工具的组合或并行使用如何代表可扩展的快速诊断的未来。
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引用次数: 17
Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis. 脑动脉瘤的血流动力学:连接医学成像和生物力学分析。
IF 9.7 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 Epub Date: 2020-03-25 DOI: 10.1146/annurev-bioeng-092419-061429
Vitaliy L Rayz, Aaron A Cohen-Gadol

In the last two decades, numerous studies have conducted patient-specific computations of blood flow dynamics in cerebral aneurysms and reported correlations between various hemodynamic metrics and aneurysmal disease progression or treatment outcomes. Nevertheless, intra-aneurysmal flow analysis has not been adopted in current clinical practice, and hemodynamic factors usually are not considered in clinical decision making. This review presents the state of the art in cerebral aneurysm imaging and image-based modeling, discussing the advantages and limitations of each approach and focusing on the translational value of hemodynamic analysis. Combining imaging and modeling data obtained from different flow modalities can improve the accuracy and fidelity of resulting velocity fields and flow-derived factors that are thought to affect aneurysmal disease progression. It is expected that predictive models utilizing hemodynamic factors in combination with patient medical history and morphological data will outperform current risk scores and treatment guidelines. Possible future directions include novel approaches enabling data assimilation and multimodality analysis of cerebral aneurysm hemodynamics.

在过去的二十年中,许多研究对脑动脉瘤的血流动力学进行了患者特异性计算,并报道了各种血流动力学指标与动脉瘤疾病进展或治疗结果之间的相关性。然而,在目前的临床实践中尚未采用动脉瘤内血流分析,在临床决策中通常不考虑血流动力学因素。本文综述了脑动脉瘤成像和基于图像的建模的最新进展,讨论了每种方法的优点和局限性,并重点介绍了血流动力学分析的翻译价值。结合从不同流动模式获得的成像和建模数据可以提高所得速度场和被认为影响动脉瘤疾病进展的流动衍生因素的准确性和保真度。预计利用血流动力学因素结合患者病史和形态学数据的预测模型将优于当前的风险评分和治疗指南。可能的未来方向包括新的方法,使数据同化和多模态分析脑动脉瘤血流动力学。
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引用次数: 24
Three-Dimensional Single-Molecule Localization Microscopy in Whole-Cell and Tissue Specimens. 全细胞和组织标本中的三维单分子定位显微镜。
IF 12.8 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 Epub Date: 2020-04-03 DOI: 10.1146/annurev-bioeng-060418-052203
Sheng Liu, Hyun Huh, Sang-Hyuk Lee, Fang Huang

Super-resolution microscopy techniques are versatile and powerful tools for visualizing organelle structures, interactions, and protein functions in biomedical research. However, whole-cell and tissue specimens challenge the achievable resolution and depth of nanoscopy methods. We focus on three-dimensional single-molecule localization microscopy and review some of the major roadblocks and developing solutions to resolving thick volumes of cells and tissues at the nanoscale in three dimensions. These challenges include background fluorescence, system- and sample-induced aberrations, and information carried by photons, as well as drift correction, volume reconstruction, and photobleaching mitigation. We also highlight examples of innovations that have demonstrated significant breakthroughs in addressing the abovementioned challenges together with their core concepts as well as their trade-offs.

超分辨率显微镜技术是生物医学研究中观察细胞器结构、相互作用和蛋白质功能的通用而强大的工具。然而,全细胞和组织标本对纳米显微镜方法的分辨率和深度提出了挑战。我们将重点放在三维单分子定位显微镜上,并回顾了在三维纳米尺度上分辨厚体积细胞和组织的一些主要障碍和正在开发的解决方案。这些挑战包括背景荧光、系统和样品引起的畸变、光子携带的信息以及漂移校正、体积重建和光漂白缓解。我们还重点介绍了在应对上述挑战方面取得重大突破的创新实例及其核心理念和利弊权衡。
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引用次数: 0
Swine Disease Models for Optimal Vascular Engineering. 最佳血管工程猪疾病模型。
IF 9.7 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2020-06-04 Epub Date: 2020-03-02 DOI: 10.1146/annurev-bioeng-082919-053009
Michael Sturek, Mouhamad Alloosh, Frank W Sellke

Swine disease models are essential for mimicry of human metabolic and vascular pathophysiology, thereby enabling high-fidelity translation to human medicine. The worldwide epidemic of obesity, metabolic disease, and diabetes has prompted the focus on these diseases in this review. We highlight the remarkable similarity between Ossabaw miniature swine and humans with metabolic syndrome and atherosclerosis. Although the evidence is strongest for swine models of coronary artery disease, findings are generally applicable to any vascular bed. We discuss the major strengths and weaknesses of swine models. The development of vascular imaging is an example of optimal vascular engineering in swine. Although challenges regarding infrastructure and training of engineers in the use of swine models exist, opportunities are ripe for gene editing, studies of molecular mechanisms, and use of swine in coronary artery imaging and testing of devices that can move quickly to human clinical studies.

猪疾病模型对于模拟人类代谢和血管病理生理至关重要,因此能够高保真地转化为人类医学。肥胖、代谢性疾病和糖尿病在世界范围内的流行引起了本文对这些疾病的关注。我们强调奥沙巴微型猪与人类代谢综合征和动脉粥样硬化的显著相似性。虽然猪冠状动脉疾病模型的证据是最强的,但研究结果通常适用于任何血管床。我们讨论了猪模型的主要优点和缺点。血管成像技术的发展是猪血管优化工程的一个例子。尽管在使用猪模型的基础设施和工程师培训方面存在挑战,但基因编辑、分子机制研究以及在冠状动脉成像和设备测试中使用猪的机会已经成熟,这些设备可以快速转移到人类临床研究。
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引用次数: 11
期刊
Annual Review of Biomedical Engineering
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