Annales De Pathologie最新文献

We report the cases of a 68-year-old man and a 78-year-old woman affected by a tumour of the parotid gland measuring 5.5cm and 6.5cm, respectively. The clinical examination found an aspect suggesting an infiltration of the parotid gland in the first case and a rapid evolution in the second case. After excision, the pathological examination showed nodular encapsulated, non-infiltrated lesions composed of adipocytes intermixed with oncocytic cell nests, with no sign of malignancy. These were two cases of oncocytic lipoadenomas of the parotid gland. Oncocytic lipoadenoma corresponds to a very rare subtype of sialolipoma, of which 38 cases have been reported in the literature since its first description in 1998. The article reviews the pathological descriptions of the tumour in comparison with its differential diagnoses, such as oncocytic-type pleomorphic adenoma and oncocytoma of the salivary glands.

In 2024, the WHO published for the first time an international classification dedicated to all pediatric tumors, marking a major milestone for the pediatric pathology community with the release of the pediatric "Blue Book." This review will focus on soft tissue connective tumors. Unsurprisingly, their classification follows the structure of the 2020 WHO classification for connective tissue tumors, organized according to histogenetic categories (adipocytic tumors, fibroblastic/myofibroblastic tumors, etc.). For each entity, we will highlight the essential elements for pathologists, emphasizing recent advances, including those not yet included in the WHO classification. Indeed, its international and consensus-based editorial process does not always allow for the integration of the most recent discoveries.

Background: Micro-computed tomography (micro-CT) offers high-resolution, three-dimensional imaging of embryonic structures, overcoming limitations of standard autopsy in early loss of pregnancy.

Objective: To assess the feasibility and relevance of micro-CT imaging in the anatomical study of a human embryo obtained from ectopic pregnancy.

Materials and methods: Following laparoscopic salpingectomy, a well-preserved 8mm embryo was extracted, fixed in formaldehyde, and stained with iodine-based contrast before being imaged using micro-CT at 12μm isotropic resolution.

Results: The embryo, classified as Carnegie stage 15, was examined in detail. Micro-CT allowed non-destructive 3D visualization of multiple internal structures, including lungs, heart, liver, spleen, neural tube, and craniofacial features.

Discussion and conclusion: Micro-CT is a promising tool for studying early human development using specimens from ectopic pregnancies. It enables detailed morphological analysis at very early stages, enhances understanding of embryogenesis, and may complement routine postmortem examinations.

Introduction: Meningothelial-type pulmonary nodules are benign and relatively common, often incidentally discovered in nearly half of properly sampled lobectomy specimens. Diffused pulmonary meningotheliomatosis is a very rare condition, the origin of which remains unknown.

Case presentation: We report two cases of disseminated pulmonary meningotheliomatosis in female patients, discovered during a lobectomy for bronchopulmonary adenocarcinoma. The diagnosis was made based on the surgical specimen, which presented multiple scattered nodules measuring 1 to 6mm with no peribronchial or subpleural pattern. The preoperative assessment revealed an associated intracranial meningioma in one patient. The other patient had chronic pulmonary inflammatory disease associated with smoking. In the two patients, there was no obvious clinical impact attributable to these disseminated micronodules.

Discussion: Through these two cases, we propose to review the main characteristics of this rare condition and the etiological hypotheses.