Pub Date : 2025-12-18DOI: 10.1016/j.annpat.2025.11.003
Ludovic Merck, Charles Lepine, Louise Galmiche-Rolland, François Le Loarer
In 2024, the WHO published for the first time an international classification dedicated to all pediatric tumors, marking a major milestone for the pediatric pathology community with the release of the pediatric "Blue Book." This review will focus on soft tissue connective tumors. Unsurprisingly, their classification follows the structure of the 2020 WHO classification for connective tissue tumors, organized according to histogenetic categories (adipocytic tumors, fibroblastic/myofibroblastic tumors, etc.). For each entity, we will highlight the essential elements for pathologists, emphasizing recent advances, including those not yet included in the WHO classification. Indeed, its international and consensus-based editorial process does not always allow for the integration of the most recent discoveries.
{"title":"[Pediatric soft tissue tumors in the 2024 WHO pediatric classification: Challenges and new developments].","authors":"Ludovic Merck, Charles Lepine, Louise Galmiche-Rolland, François Le Loarer","doi":"10.1016/j.annpat.2025.11.003","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.11.003","url":null,"abstract":"<p><p>In 2024, the WHO published for the first time an international classification dedicated to all pediatric tumors, marking a major milestone for the pediatric pathology community with the release of the pediatric \"Blue Book.\" This review will focus on soft tissue connective tumors. Unsurprisingly, their classification follows the structure of the 2020 WHO classification for connective tissue tumors, organized according to histogenetic categories (adipocytic tumors, fibroblastic/myofibroblastic tumors, etc.). For each entity, we will highlight the essential elements for pathologists, emphasizing recent advances, including those not yet included in the WHO classification. Indeed, its international and consensus-based editorial process does not always allow for the integration of the most recent discoveries.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.annpat.2025.11.007
Alexis Trecourt, Mojgan Devouassoux-Shisheboran
{"title":"[Introduction - Histoseminar sex cord-stromal tumors of the ovary].","authors":"Alexis Trecourt, Mojgan Devouassoux-Shisheboran","doi":"10.1016/j.annpat.2025.11.007","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.11.007","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-03DOI: 10.1016/j.annpat.2025.11.002
Romain Martineau, Maïda Cardoso, Audrey Lamouroux
Background: Micro-computed tomography (micro-CT) offers high-resolution, three-dimensional imaging of embryonic structures, overcoming limitations of standard autopsy in early loss of pregnancy.
Objective: To assess the feasibility and relevance of micro-CT imaging in the anatomical study of a human embryo obtained from ectopic pregnancy.
Materials and methods: Following laparoscopic salpingectomy, a well-preserved 8mm embryo was extracted, fixed in formaldehyde, and stained with iodine-based contrast before being imaged using micro-CT at 12μm isotropic resolution.
Results: The embryo, classified as Carnegie stage 15, was examined in detail. Micro-CT allowed non-destructive 3D visualization of multiple internal structures, including lungs, heart, liver, spleen, neural tube, and craniofacial features.
Discussion and conclusion: Micro-CT is a promising tool for studying early human development using specimens from ectopic pregnancies. It enables detailed morphological analysis at very early stages, enhances understanding of embryogenesis, and may complement routine postmortem examinations.
{"title":"[Anatomical study of an early human embryo from an ectopic pregnancy by micro-computed tomography].","authors":"Romain Martineau, Maïda Cardoso, Audrey Lamouroux","doi":"10.1016/j.annpat.2025.11.002","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.11.002","url":null,"abstract":"<p><strong>Background: </strong>Micro-computed tomography (micro-CT) offers high-resolution, three-dimensional imaging of embryonic structures, overcoming limitations of standard autopsy in early loss of pregnancy.</p><p><strong>Objective: </strong>To assess the feasibility and relevance of micro-CT imaging in the anatomical study of a human embryo obtained from ectopic pregnancy.</p><p><strong>Materials and methods: </strong>Following laparoscopic salpingectomy, a well-preserved 8mm embryo was extracted, fixed in formaldehyde, and stained with iodine-based contrast before being imaged using micro-CT at 12μm isotropic resolution.</p><p><strong>Results: </strong>The embryo, classified as Carnegie stage 15, was examined in detail. Micro-CT allowed non-destructive 3D visualization of multiple internal structures, including lungs, heart, liver, spleen, neural tube, and craniofacial features.</p><p><strong>Discussion and conclusion: </strong>Micro-CT is a promising tool for studying early human development using specimens from ectopic pregnancies. It enables detailed morphological analysis at very early stages, enhances understanding of embryogenesis, and may complement routine postmortem examinations.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-03DOI: 10.1016/j.annpat.2025.11.001
Clémence Yguel, Aude Marchal, Bruno Mouget, Faïçal Maadi, Brice Caput, Aurélie Cazes, Alice Guyard
Introduction: Meningothelial-type pulmonary nodules are benign and relatively common, often incidentally discovered in nearly half of properly sampled lobectomy specimens. Diffused pulmonary meningotheliomatosis is a very rare condition, the origin of which remains unknown.
Case presentation: We report two cases of disseminated pulmonary meningotheliomatosis in female patients, discovered during a lobectomy for bronchopulmonary adenocarcinoma. The diagnosis was made based on the surgical specimen, which presented multiple scattered nodules measuring 1 to 6mm with no peribronchial or subpleural pattern. The preoperative assessment revealed an associated intracranial meningioma in one patient. The other patient had chronic pulmonary inflammatory disease associated with smoking. In the two patients, there was no obvious clinical impact attributable to these disseminated micronodules.
Discussion: Through these two cases, we propose to review the main characteristics of this rare condition and the etiological hypotheses.
{"title":"[About two cases of diffuse pulmonary meningotheliomatosis in female patients operated on for lung adenocarcinoma].","authors":"Clémence Yguel, Aude Marchal, Bruno Mouget, Faïçal Maadi, Brice Caput, Aurélie Cazes, Alice Guyard","doi":"10.1016/j.annpat.2025.11.001","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.11.001","url":null,"abstract":"<p><strong>Introduction: </strong>Meningothelial-type pulmonary nodules are benign and relatively common, often incidentally discovered in nearly half of properly sampled lobectomy specimens. Diffused pulmonary meningotheliomatosis is a very rare condition, the origin of which remains unknown.</p><p><strong>Case presentation: </strong>We report two cases of disseminated pulmonary meningotheliomatosis in female patients, discovered during a lobectomy for bronchopulmonary adenocarcinoma. The diagnosis was made based on the surgical specimen, which presented multiple scattered nodules measuring 1 to 6mm with no peribronchial or subpleural pattern. The preoperative assessment revealed an associated intracranial meningioma in one patient. The other patient had chronic pulmonary inflammatory disease associated with smoking. In the two patients, there was no obvious clinical impact attributable to these disseminated micronodules.</p><p><strong>Discussion: </strong>Through these two cases, we propose to review the main characteristics of this rare condition and the etiological hypotheses.</p>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.annpat.2025.09.003
Ismaïl Braham, Sarah Bellal
{"title":"[Acute intussusception secondary to Meckel's diverticulum].","authors":"Ismaïl Braham, Sarah Bellal","doi":"10.1016/j.annpat.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.annpat.2025.09.003","url":null,"abstract":"","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.annpat.2025.04.011
Samia Boussouar , Mathilde Wagner
<div><div>Les kystes sont des anomalies fréquentes en imagerie, présentant une grande diversité de localisations et de mécanismes pathophysiologiques. Leur classification repose sur des critères morphologiques et cliniques permettant de guider le diagnostic et l’orientation thérapeutique. Cet article aborde principalement les kystes pulmonaires tout en évoquant brièvement ceux du foie et du pancréas. Les lésions kystiques pulmonaires sont souvent le résultat de processus infectieux, inflammatoires, néoplasiques ou lymphoprolifératifs. Le scanner thoracique est l’outil diagnostique principal dans leur évaluation, permettant de différencier ces lésions des autres anomalies pulmonaires, telles que l’emphysème ou les bronchectasies. Selon les caractéristiques cliniques et radiologiques, les kystes pulmonaires peuvent être associés à des pathologies spécifiques comme la lymphangioléiomyomatose, l’histiocytose langerhansienne ou la maladie de Birt-Hogg-Dubé. Bien que les biopsies pulmonaires chirurgicales soient rarement nécessaires, elles sont parfois essentielles pour un diagnostic précis lorsque les images ne permettent pas de conclure. Ces biopsies doivent être ciblées selon les images au scanner, avec des échantillons suffisants pour optimiser le rendement diagnostique. En imagerie hépato-pancréatique, la détection de lésions kystiques présentant des rehaussements, des cloisons ou des parois tissulaires épaissies, en dehors de tout contexte infectieux, doit faire l’objet d’une évaluation multidisciplinaire afin de discuter l’indication de prélèvements ciblés et de préciser le diagnostic étiologique, notamment en regard d’une potentielle malignité. Enfin, une coopération étroite entre radiologues et anatomopathologistes est essentielle afin d’assurer une caractérisation diagnostique précise des pathologies kystiques, en intégrant les corrélations anatomo-radiologiques nécessaires à une prise en charge optimale.</div></div><div><div>Cysts are common abnormalities in imaging, exhibiting a wide range of localizations and pathophysiological mechanisms. Their classification is based on morphological and clinical criteria guiding both diagnostic and therapeutic management. This article primarily focuses on pulmonary cysts, while briefly addressing hepatic and pancreatic cysts. Pulmonary cystic lesions are often the result of infectious, inflammatory, neoplastic or lymphoproliferative processes. Thoracic computed tomography is the key diagnostic tool for their evaluation, helping to differentiate these lesions from other pulmonary abnormalities, such as emphysema or bronchiectasis. Depending on clinical and radiological features, pulmonary cysts may be associated with specific disorders including lymphangioleiomyomatosis, Langerhans cell histiocytosis, or Birt-Hogg-Dubé syndrome. Although surgical pulmonary biopsies are rarely necessary, they may be essential for definitive diagnosis when imaging fails to provide a definitive conclusion. Such biopsies sh
{"title":"Radiologie des kystes : analyse et classification des kystes pulmonaires et hépato-pancréatiques en imagerie","authors":"Samia Boussouar , Mathilde Wagner","doi":"10.1016/j.annpat.2025.04.011","DOIUrl":"10.1016/j.annpat.2025.04.011","url":null,"abstract":"<div><div>Les kystes sont des anomalies fréquentes en imagerie, présentant une grande diversité de localisations et de mécanismes pathophysiologiques. Leur classification repose sur des critères morphologiques et cliniques permettant de guider le diagnostic et l’orientation thérapeutique. Cet article aborde principalement les kystes pulmonaires tout en évoquant brièvement ceux du foie et du pancréas. Les lésions kystiques pulmonaires sont souvent le résultat de processus infectieux, inflammatoires, néoplasiques ou lymphoprolifératifs. Le scanner thoracique est l’outil diagnostique principal dans leur évaluation, permettant de différencier ces lésions des autres anomalies pulmonaires, telles que l’emphysème ou les bronchectasies. Selon les caractéristiques cliniques et radiologiques, les kystes pulmonaires peuvent être associés à des pathologies spécifiques comme la lymphangioléiomyomatose, l’histiocytose langerhansienne ou la maladie de Birt-Hogg-Dubé. Bien que les biopsies pulmonaires chirurgicales soient rarement nécessaires, elles sont parfois essentielles pour un diagnostic précis lorsque les images ne permettent pas de conclure. Ces biopsies doivent être ciblées selon les images au scanner, avec des échantillons suffisants pour optimiser le rendement diagnostique. En imagerie hépato-pancréatique, la détection de lésions kystiques présentant des rehaussements, des cloisons ou des parois tissulaires épaissies, en dehors de tout contexte infectieux, doit faire l’objet d’une évaluation multidisciplinaire afin de discuter l’indication de prélèvements ciblés et de préciser le diagnostic étiologique, notamment en regard d’une potentielle malignité. Enfin, une coopération étroite entre radiologues et anatomopathologistes est essentielle afin d’assurer une caractérisation diagnostique précise des pathologies kystiques, en intégrant les corrélations anatomo-radiologiques nécessaires à une prise en charge optimale.</div></div><div><div>Cysts are common abnormalities in imaging, exhibiting a wide range of localizations and pathophysiological mechanisms. Their classification is based on morphological and clinical criteria guiding both diagnostic and therapeutic management. This article primarily focuses on pulmonary cysts, while briefly addressing hepatic and pancreatic cysts. Pulmonary cystic lesions are often the result of infectious, inflammatory, neoplastic or lymphoproliferative processes. Thoracic computed tomography is the key diagnostic tool for their evaluation, helping to differentiate these lesions from other pulmonary abnormalities, such as emphysema or bronchiectasis. Depending on clinical and radiological features, pulmonary cysts may be associated with specific disorders including lymphangioleiomyomatosis, Langerhans cell histiocytosis, or Birt-Hogg-Dubé syndrome. Although surgical pulmonary biopsies are rarely necessary, they may be essential for definitive diagnosis when imaging fails to provide a definitive conclusion. Such biopsies sh","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 6","pages":"Pages 489-496"},"PeriodicalIF":0.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.annpat.2025.05.003
Mohamed Amine Bani
Les kystes, anomalies pathologiques fréquentes et ubiquitaires, sont définis comme des cavités bordées d’une paroi et remplies de liquide ou de matériel semi-solide. Ils résultent de mécanismes complexes combinant altérations génétiques, forces biophysiques et interactions avec le microenvironnement tissulaire. Les récents progrès en génomique ont permis d’identifier des mutations clés, qui altèrent la polarité cellulaire, la signalisation intracellulaire et les flux hydriques. Parallèlement, les modèles biophysiques révèlent l’impact des forces mécaniques et osmotiques sur la croissance et la rupture des kystes. Les modèles multi-échelles, intégrant ces approches, relient les mécanismes moléculaires aux dynamiques tissulaires, offrant des outils puissants permettant de comprendre les interactions complexes à l’origine des kystes. Ces avancées ouvrent des perspectives prometteuses sur le plan diagnostique, avec des biomarqueurs génétiques et biophysiques, et thérapeutiques. Cet article propose une mise au point intégrative des mécanismes génétiques et biophysiques des kystes et explore leurs applications cliniques dans une démarche multidisciplinaire.
Cysts, common and ubiquitous pathological anomalies, are defined as cavities lined by a distinct wall and filled with fluid or semi-solid material. They result from complex mechanisms involving genetic alterations, biophysical forces, and tissue microenvironment interactions. Recent advances in genomics have identified key mutations that disrupt cell polarity, intracellular signaling, and fluid dynamics. Concurrently, biophysical models elucidate the impact of mechanical and osmotic forces on cyst growth and rupture. Multiscale models, integrating these approaches, connect molecular mechanisms to tissue dynamics, providing powerful tools to unravel the complex interactions driving cyst formation. These advances offer promising perspectives in terms of diagnosis, through genetic and biophysical biomarkers and therapeutics. This article provides an integrative update on the genetic and biophysical mechanisms of cysts and explores their clinical applications within a multidisciplinary framework.
{"title":"Physiopathologie des kystes : une approche intégrée génomique et biophysique","authors":"Mohamed Amine Bani","doi":"10.1016/j.annpat.2025.05.003","DOIUrl":"10.1016/j.annpat.2025.05.003","url":null,"abstract":"<div><div>Les kystes, anomalies pathologiques fréquentes et ubiquitaires, sont définis comme des cavités bordées d’une paroi et remplies de liquide ou de matériel semi-solide. Ils résultent de mécanismes complexes combinant altérations génétiques, forces biophysiques et interactions avec le microenvironnement tissulaire. Les récents progrès en génomique ont permis d’identifier des mutations clés, qui altèrent la polarité cellulaire, la signalisation intracellulaire et les flux hydriques. Parallèlement, les modèles biophysiques révèlent l’impact des forces mécaniques et osmotiques sur la croissance et la rupture des kystes. Les modèles multi-échelles, intégrant ces approches, relient les mécanismes moléculaires aux dynamiques tissulaires, offrant des outils puissants permettant de comprendre les interactions complexes à l’origine des kystes. Ces avancées ouvrent des perspectives prometteuses sur le plan diagnostique, avec des biomarqueurs génétiques et biophysiques, et thérapeutiques. Cet article propose une mise au point intégrative des mécanismes génétiques et biophysiques des kystes et explore leurs applications cliniques dans une démarche multidisciplinaire.</div></div><div><div>Cysts, common and ubiquitous pathological anomalies, are defined as cavities lined by a distinct wall and filled with fluid or semi-solid material. They result from complex mechanisms involving genetic alterations, biophysical forces, and tissue microenvironment interactions. Recent advances in genomics have identified key mutations that disrupt cell polarity, intracellular signaling, and fluid dynamics. Concurrently, biophysical models elucidate the impact of mechanical and osmotic forces on cyst growth and rupture. Multiscale models, integrating these approaches, connect molecular mechanisms to tissue dynamics, providing powerful tools to unravel the complex interactions driving cyst formation. These advances offer promising perspectives in terms of diagnosis, through genetic and biophysical biomarkers and therapeutics. This article provides an integrative update on the genetic and biophysical mechanisms of cysts and explores their clinical applications within a multidisciplinary framework.</div></div>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 6","pages":"Pages 463-472"},"PeriodicalIF":0.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.annpat.2025.05.001
Maya Nourieh
Les kystes rénaux sont fréquents. Ils comprennent les kystes simples asymptomatiques et des tumeurs kystiques ou secondairement kystisées. Les critères radiologiques permettent de différencier les kystes bénins des kystes suspects de malignité nécessitant une exérèse et une confirmation histopathologique.
Renal cysts are common. They include asymptomatic simple cysts and cystic or secondarily cystic tumors. Radiological criteria allow differentiation between benign cysts and cysts suspect of malignancy, which require excision and histopathological confirmation.
{"title":"Cas n̊1. Les kystes rénaux","authors":"Maya Nourieh","doi":"10.1016/j.annpat.2025.05.001","DOIUrl":"10.1016/j.annpat.2025.05.001","url":null,"abstract":"<div><div>Les kystes rénaux sont fréquents. Ils comprennent les kystes simples asymptomatiques et des tumeurs kystiques ou secondairement kystisées. Les critères radiologiques permettent de différencier les kystes bénins des kystes suspects de malignité nécessitant une exérèse et une confirmation histopathologique.</div></div><div><div>Renal cysts are common. They include asymptomatic simple cysts and cystic or secondarily cystic tumors. Radiological criteria allow differentiation between benign cysts and cysts suspect of malignancy, which require excision and histopathological confirmation.</div></div>","PeriodicalId":50969,"journal":{"name":"Annales De Pathologie","volume":"45 6","pages":"Pages 523-531"},"PeriodicalIF":0.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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