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Building and Breaking the Chain: A Model of Reward Prediction Error Integration and Segmentation of Memory 建立和打破记忆链:奖赏预测错误整合与记忆分割模型。
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-29 DOI: 10.1162/jocn_a_02215
Nina Rouhani;David Clewett;James W. Antony
Prediction errors drive reinforcement learning and organize episodic memory into distinct contexts, but do these effects interact? Here, we review the roles of midbrain dopamine, the locus coeruleus, and the hippocampus in event cognition to propose and simulate the theoretical influence of two prediction error signals in integrating versus segmenting events in memory. We suggest that signed reward prediction errors can build mental models of reward environments, increasing the contextual similarity (integration) of experiences with stronger, more stable reward expectations. On the other hand, unsigned reward prediction errors can signal a new model of the environment, generating a contextual shift (segmentation) between experiences that crossed them. We moreover predicted that these differences in contextual similarity give rise to distinct patterns of temporal-order memory. We combined these ideas in a computational model to account for a seemingly paradoxical pattern of temporal-order memory where greater representational distance helps order memory within context but impairs it across contexts. We found that simulating signed reward prediction error integration and unsigned reward prediction error segmentation differentially enabled the model to perform associative chaining, which involved reactivating items between two tested probes to assist with sequential retrieval. In summary, our simulations provide a unifying explanation for the varied ways that neuromodulatory systems may alter event cognition and memory.
预测错误会推动强化学习并将外显记忆组织到不同的情境中,但这些影响是否会相互影响呢?在这里,我们回顾了中脑多巴胺、神经节和海马在事件认知中的作用,提出并模拟了两种预测错误信号在整合与分割记忆事件中的理论影响。我们认为,有符号的奖赏预测错误可以建立奖赏环境的心理模型,增加具有更强、更稳定的奖赏预期的经历的情境相似性(整合)。另一方面,无符号的奖励预测错误则可能预示着一种新的环境模型,在与之交叉的经历之间产生情境转换(分割)。此外,我们还预测这些情境相似性的差异会产生不同的时序记忆模式。我们将这些想法结合到一个计算模型中,以解释一种看似矛盾的时序记忆模式,即更大的表征距离有助于情境内的时序记忆,但却会损害跨情境记忆。我们发现,模拟有符号奖励预测误差整合和无符号奖励预测误差分割可使模型执行联想连锁,这涉及重新激活两个测试探针之间的项目,以协助顺序检索。总之,我们的模拟为神经调节系统改变事件认知和记忆的各种方式提供了统一的解释。
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引用次数: 0
Causal and Chronological Relationships Predict Memory Organization for Nonlinear Narratives 因果关系和时序关系可预测非线性叙事的记忆组织。
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-29 DOI: 10.1162/jocn_a_02216
James Antony;Angelo Lozano;Pahul Dhoat;Janice Chen;Kelly Bennion
While recounting an experience, one can employ multiple strategies to transition from one part to the next. For instance, if the event was learned out of linear order, one can recall events according to the time they were learned (temporal), similar events (semantic), events occurring nearby in time (chronological), or events produced by the current event (causal). To disentangle the importance of these factors, we had participants watch the nonlinear narrative, Memento, under different task instructions and presentation orders. For each scene of the film, we also separately computed semantic and causal networks. We then contrasted the evidence for temporal, semantic, chronological, or causal strategies during recall. Critically, there was stronger evidence for the causal and chronological strategies than semantic or temporal strategies. Moreover, the causal and chronological strategies outperformed the temporal one even when we asked participants to recall the film in the presented order, underscoring the fundamental nature of causal structure in scaffolding understanding and organizing recall. Nevertheless, time still marginally predicted recall transitions, suggesting it operates as a weak signal in the presence of more salient forms of structure. In addition, semantic and causal network properties predicted scene memorability, including a stronger role for incoming causes to an event than its outgoing effects. In summary, these findings highlight the importance of accounting for complex, causal networks in knowledge building and memory.
在回忆一段经历时,可以采用多种策略从一个部分过渡到下一部分。例如,如果学习的事件没有按照线性顺序排列,那么可以根据学习的时间(时间性)、类似事件(语义性)、时间上邻近的事件(时间性)或当前事件产生的事件(因果性)来回忆事件。为了区分这些因素的重要性,我们让参与者在不同的任务指令和呈现顺序下观看非线性叙事电影《追忆》。对于影片中的每个场景,我们还分别计算了语义网络和因果网络。通过这些推导,我们对比了回忆过程中时间策略、语义策略、时间策略或因果策略的证据。重要的是,与语义或时间策略相比,因果策略和时间策略的证据更为充分。此外,即使要求被试按照呈现的顺序回忆影片,因果和时间策略的表现也优于时间策略,这突出了因果结构在帮助理解和组织回忆方面的基本性质。尽管如此,时间对回忆转换的预测作用仍然微弱,这表明在存在更突出的结构形式时,时间仍然是一个微弱的信号。此外,语义和因果网络的特性也能预测场景的可记性,包括显示事件的起因比事件的外显效果起更大的作用。总之,这些效应凸显了在知识构建和记忆中考虑复杂因果网络的重要性。
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引用次数: 0
Endogenous Attention Affects Decision-related Neural Activity but Not Afferent Visual Responses 内源性注意力会影响与决策相关的神经活动,但不会影响传入视觉反应
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-29 DOI: 10.1162/jocn_a_02239
Audrey Morrow;April Pilipenko;Elise Turkovich;Soorya Sankaran;Jason Samaha
Endogenous shifts of spatial attention toward an upcoming stimulus are associated with improvements in behavioral responses to the stimulus, preparatory retinotopic shifts in alpha power, and changes in ERPs. Although attentional modulation of several early sensory ERPs is well established, there is still debate about under what circumstances attention affects the earliest cortical visual evoked response—the C1 ERP component—which is putatively generated from afferent input into primary visual cortex. Moreover, the effects of spatial attention on the recently discovered ERP signature of evidence accumulation—the central parietal positivity (CPP)—have not been fully characterized. The present study assessed the effect of spatial attention on the C1 and CPP components through a spatially cued contrast discrimination task using stimuli that were specifically designed to produce large-amplitude C1 responses and that varied in sensory evidence strength to characterize the CPP. Participants responded according to which of two checkerboard stimuli had greater contrast following an 80% valid cue toward the upper or lower visual field. Prestimulus alpha power changed topographically based on the cue, suggesting participants shifted attention to prepare for the upcoming stimuli. Despite these attentional shifts in alpha power and the fact that the stimuli reliably elicited C1 responses several times greater than many prior studies, there was no evidence of an attention effect on the C1. The CPP, however, showed a clear increase in build-up rate on valid trials. Our findings suggest that endogenous attention may not affect the early C1 ERP component but may improve behavior at a decision stage, as reflected in brain signals related to evidence accumulation (the CPP).
对即将到来的刺激的内源性空间注意力转移与对刺激的行为反应的改善、α功率的视网膜准备性转移以及 ERPs 的变化有关。虽然注意力对几种早期感觉ERP的调节作用已经得到证实,但关于注意力在什么情况下会影响最早的皮层视觉诱发反应--C1 ERP成分--这种反应可能是由初级视觉皮层的传入输入产生的,目前仍存在争议。此外,空间注意对最近发现的证据积累的ERP特征--顶叶中央阳性(CPP)--的影响尚未完全定性。本研究通过一项空间诱导对比度分辨任务来评估空间注意力对 C1 和 CPP 成分的影响,该任务使用的刺激物专门设计用于产生大振幅 C1 反应,并通过感官证据强度的变化来描述 CPP 的特征。在对上视野或下视野进行 80% 有效提示后,受试者会根据两个棋盘式刺激物中哪个对比度更大做出反应。刺激前的α功率会根据提示发生地形变化,这表明参与者会转移注意力,为即将到来的刺激做好准备。尽管α功率发生了这些注意力转移,而且这些刺激引起的 C1 反应比之前的许多研究可靠地高出数倍,但没有证据表明注意力对 C1 有影响。然而,在有效试验中,CPP 的建立率明显增加。我们的研究结果表明,内源性注意力可能不会影响早期的 C1 ERP 成分,但可能会改善决策阶段的行为,这一点反映在与证据积累(CPP)相关的大脑信号中。
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引用次数: 0
Medial Temporal Lobe Damage Impairs Temporal Integration in Episodic Memory 内侧颞叶损伤会损害外显记忆中的时空整合能力
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-29 DOI: 10.1162/jocn_a_02222
Sarah DuBrow;Brynn E. Sherman;Michael R. Meager;Lila Davachi
Although the role of the medial temporal lobe (MTL) and the hippocampus in episodic memory is well established, there is emerging evidence that these regions play a broader role in cognition, specifically in temporal processing. However, despite strong evidence that the hippocampus plays a critical role in sequential processing, the involvement of the MTL in timing per se is poorly understood. In the present study, we investigated whether patients with MTL damage exhibit differential performance on a temporal distance memory task. Critically, we manipulated context shifts, or boundaries, which have been shown to interfere with associative binding, leading to increases in subjective temporal distance. We predicted that patients with MTL damage would show impaired binding across boundaries and thus fail to show temporal expansion. Consistent with this hypothesis, unilateral patients failed to show a temporal expansion effect, and bilateral patients actually exhibited the reverse effect, suggesting a critical role for the MTL in binding temporal information across boundaries. Furthermore, patients were impaired overall on both the temporal distance memory task and recognition memory, but not on an independent, short-timescale temporal perception task. Interestingly, temporal distance performance could be independently predicted by performance on recognition memory and the short temporal perception task. Together, these data suggest that distinct mnemonic and temporal processes may influence long interval temporal memory and that damage to the MTL may impair the ability to integrate episodic and temporal information in memory.
尽管内侧颞叶(MTL)和海马在情节记忆中的作用已得到公认,但新出现的证据表明,这些区域在认知中发挥着更广泛的作用,特别是在时间处理中。然而,尽管有强有力的证据表明海马在顺序加工中发挥着关键作用,但人们对 MTL 在时间本身的参与却知之甚少。在本研究中,我们调查了 MTL 受损患者在时距记忆任务中是否表现出不同的表现。重要的是,我们对上下文转移或边界进行了操作,事实证明,边界会干扰联想结合,从而导致主观时距的增加。我们预测,MTL受损的患者将表现出跨边界的联结能力受损,从而无法表现出时间扩展。与这一假设相符的是,单侧患者未能表现出时间扩展效应,而双侧患者实际上表现出相反的效应,这表明 MTL 在跨边界结合时间信息方面起着关键作用。此外,患者在时距记忆任务和识别记忆中的总体表现均受损,但在一项独立的短时标时间感知任务中却没有受损。有趣的是,识别记忆和短时标时间感知任务的表现可以独立预测患者的时距表现。这些数据共同表明,不同的记忆过程和时间过程可能会影响长间隔时间记忆,而 MTL 的损伤可能会损害记忆中整合情节信息和时间信息的能力。
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引用次数: 0
Recall as a Window into Hippocampally Defined Events 回忆是了解海马定义事件的窗口
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-29 DOI: 10.1162/jocn_a_02198
Lindsay I. Rait;J. Benjamin Hutchinson
We experience the present as a continuous stream of information, but often experience the past in parcels of unique events or episodes. Decades of research have helped to articulate how we perform this event segmentation in the moment, as well as how events and their boundaries influence what we later remember. More recently, neuroscientific research has suggested that the hippocampus plays a role at critical moments during event formation alongside its established role in enabling subsequent recall. Here, we review and explore the relationship between event processing and recall with the perspective that it can be uniquely characterized by the contributions of the hippocampus and its interactions with the rest of the brain. Specifically, we highlight a growing number of empirical studies suggesting that the hippocampus is important for processing events that have just ended, bridging the gap between the prior and current event, and influencing the contents and trajectories of recalled information. We also catalogue and summarize the multifaceted sets of findings concerning how recall is influenced by event structure. Lastly, we discuss several exciting directions for future research and how our understanding of events might be enriched by characterizing them in terms of the operations of different regions of the brain.
我们对现在的体验是连续不断的信息流,但对过去的体验往往是由一些独特的事件或片段组成的。数十年的研究帮助我们阐明了我们如何在当下进行这种事件分割,以及事件及其边界如何影响我们后来的记忆。最近,神经科学研究表明,海马体在事件形成过程中的关键时刻发挥着作用,同时它在之后的回忆中也发挥着既定的作用。在此,我们回顾并探讨了事件处理与回忆之间的关系,并从海马体的贡献及其与大脑其他部分的相互作用这一角度对这一关系进行了独特的描述。具体来说,我们强调越来越多的实证研究表明,海马体对于处理刚刚结束的事件、弥合先前事件和当前事件之间的差距以及影响回忆信息的内容和轨迹非常重要。我们还对有关回忆如何受事件结构影响的多方面研究结果进行了分类和总结。最后,我们讨论了未来研究的几个令人兴奋的方向,以及如何通过描述大脑不同区域的运作来丰富我们对事件的理解。
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引用次数: 0
Introduction to the Special Focus: Remembering Sarah DuBrow 特别关注介绍:缅怀莎拉-杜布朗
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-29 DOI: 10.1162/jocn_a_02246
Lila Davachi;Vishnu P. Murty
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引用次数: 0
Time after Time: Preserving Temporal Memories When Experiences Repeat 时过境迁:当经历重复时保存时间记忆。
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-29 DOI: 10.1162/jocn_a_02212
Futing Zou;Brice A. Kuhl
Remembering when events occur in time is fundamental to episodic memory. Yet, many experiences repeat over time creating the potential for interference when attempting to recall temporally specific memories. Here, we argue that temporal memories are protected, in part, by reinstatement of temporal context information that is triggered by stimulus repetitions. We motivate this argument by integrating seminal findings across several distinct literatures and methodologies. Specifically, we consider key insights from foundational behavioral studies of temporal memory, recent electrophysiological and neuroimaging approaches to measuring memory reinstatement, and computational models that describe how temporal context representations shape memory processes. We also note several open questions concerning how temporal context reinstatement might influence subsequent temporal memory, including potential mediating effects of event spacing and event boundaries. These ideas and questions have the potential to guide future research and, ultimately, to advance theoretical accounts of how we preserve temporal memories.
记住事件发生的时间是外显记忆的基础。然而,许多经历会随着时间的推移而重复,这就为试图回忆特定时间记忆时造成了潜在的干扰。在这里,我们认为时间记忆在一定程度上是通过刺激重复所引发的时间背景信息的恢复而得到保护的。我们通过整合几种不同文献和方法中的开创性研究成果来激发这一论点。具体来说,我们考虑了时间记忆的基础行为研究、最近测量记忆恢复的电生理学和神经影像学方法以及描述时间语境表征如何塑造记忆过程的计算模型中的关键见解。我们还注意到一些有关时间情境恢复如何影响后续时间记忆的开放性问题,包括事件间距和事件边界的潜在中介效应。这些观点和问题有可能会指导未来的研究,并最终推动关于我们如何保存时间记忆的理论研究。
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引用次数: 0
The Ubiquity of Time in Latent-cause Inference 潜因推断中时间的不确定性。
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-29 DOI: 10.1162/jocn_a_02231
Dan-Mircea Mirea;Yeon Soon Shin;Sarah DuBrow;Yael Niv
Humans have an outstanding ability to generalize from past experiences, which requires parsing continuously experienced events into discrete, coherent units, and relating them to similar past experiences. Time is a key element in this process; however, how temporal information is used in generalization remains unclear. Latent-cause inference provides a Bayesian framework for clustering experiences, by building a world model in which related experiences are generated by a shared cause. Here, we examine how temporal information is used in latent-cause inference, using a novel task in which participants see “microbe” stimuli and explicitly report the latent cause (“strain”) they infer for each microbe. We show that humans incorporate time in their inference of latent causes, such that recently inferred latent causes are more likely to be inferred again. In particular, a “persistent” model, in which the latent cause inferred for one observation has a fixed probability of continuing to cause the next observation, explains the data significantly better than two other time-sensitive models, although extensive individual differences exist. We show that our task and this model have good psychometric properties, highlighting their potential use for quantifying individual differences in computational psychiatry or in neuroimaging studies.
人类从过去的经验中归纳出卓越的能力,这需要将连续经历的事件解析为离散、连贯的单元,并将它们与过去的类似经验联系起来。在这一过程中,时间是一个关键因素;然而,在归纳过程中如何使用时间信息仍不清楚。潜在原因推理提供了一个贝叶斯框架,通过建立一个世界模型,其中相关的经验是由一个共同的原因产生的,从而对经验进行聚类。在这里,我们通过一项新颖的任务,让参与者观看 "微生物 "刺激,并明确报告他们为每种微生物推断出的潜在原因("菌株"),来研究时间信息在潜在原因推断中的应用。我们的研究表明,人类在推断潜因时会考虑时间因素,因此最近推断出的潜因更有可能再次被推断出来。特别是 "持续 "模型,即在一次观察中推断出的潜因有固定概率继续导致下一次观察,对数据的解释能力明显优于其他两种时间敏感模型,尽管个体差异很大。我们的研究表明,我们的任务和这一模型具有良好的心理测量特性,突出了它们在计算精神病学或神经成像研究中量化个体差异的潜在用途。
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引用次数: 0
Threat Impairs the Organization of Memory Around Motivational Context 威胁会损害围绕动机情境的记忆组织
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-29 DOI: 10.1162/jocn_a_02242
Elizabeth A. Horwath;Brandon S. Katerman;Meryl Biju;Sarah DuBrow;Vishnu P. Murty
Previous work highlighted a critical role for top–down goals in shifting memory organization, namely, through studying the downstream influences of event segmentation and task switching on free recall. Here, we extend these frameworks into the realm of motivation, by comparing how threat motivation influences memory organization by capturing free recall dynamics. In Study 1, we manipulated individuals' motivation to successfully encode information by the threat of exposure to aversive sounds for forgetting. In Study 2, we conducted a parallel study manipulating motivation via instruction rather than threat, allowing us to examine changes directly related to threat motivation. Our findings showed that motivation to avoid threat broadly enhances memory for items presented within a threatening context, regardless of whether items were directly associated with the threat or not. Concurrently, these memory enhancements coincide with a decrease in the organization of memory around motivationally relevant features. These results highlight the importance of considering motivational valence when conceptualizing memory organization within adaptive memory frameworks.
以前的工作强调了自上而下的目标在改变记忆组织中的关键作用,即通过研究事件分割和任务转换对自由回忆的下游影响。在此,我们将这些框架扩展到动机领域,通过捕捉自由回忆动态来比较威胁动机如何影响记忆组织。在研究1中,我们通过暴露于遗忘的厌恶声音的威胁来操纵个体成功编码信息的动机。在研究 2 中,我们进行了一项平行研究,通过指令而非威胁来操纵动机,从而考察了与威胁动机直接相关的变化。我们的研究结果表明,无论项目是否与威胁直接相关,避免威胁的动机都能广泛增强对威胁情境下呈现的项目的记忆。与此同时,这些记忆的增强与围绕动机相关特征的记忆组织的减少相吻合。这些结果凸显了在适应性记忆框架内对记忆组织进行概念化时考虑动机价值的重要性。
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引用次数: 0
Announcing the Journal of Cognitive Neuroscience Discussion Forum. 认知神经科学杂志》讨论论坛揭晓。
IF 3.1 3区 医学 Q2 NEUROSCIENCES Pub Date : 2024-10-28 DOI: 10.1162/jocn_e_02259
Bradley R Postle
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引用次数: 0
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Journal of Cognitive Neuroscience
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